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Full-Text Articles in Medicine and Health Sciences

The Apex Bone Wearing Out In The Light Of Sharia And Science, Omar Gabis Aug 2023

The Apex Bone Wearing Out In The Light Of Sharia And Science, Omar Gabis

An-Najah University Journal for Research - B (Humanities)

This research studies an issue in which Sharia scholars differed in the past, while was not of interest to scholars recently, namely: Does the last part of the human coccyx bone (apex) dissolve? Some hadith mentioned that the apex wears out, which was the reason for the divergence of the opinions of scholars in answer to this question over time. As far as informed, the researcher did not find a schooler who singled out this issue in any scientific research. The difficulty of answering this question may lie in the inability to conduct empirical research on this part, in addition …


The Importance Of Contrast Sensitivity, Color Vision, And Electrophysiological Testing In Clinical And Occupational Settings, Frances Silva Aug 2023

The Importance Of Contrast Sensitivity, Color Vision, And Electrophysiological Testing In Clinical And Occupational Settings, Frances Silva

Theses & Dissertations

Visual acuity (VA) is universally accepted as the gold standard metric for ocular vision and function. Contrast sensitivity (CS), color vision, and electrophysiological testing for clinical and occupational settings are warranted despite being deemed ancillary and minimally utilized by clinicians. These assessments provide essential information to subjectively and objectively quantify and obtain optimal functional vision. They are useful for baseline data and monitoring hereditary and progressive ocular conditions and cognitive function. The studies in this dissertation highlight the value of contrast sensitivity, color vision, and cone specific electrophysiological testing, as well as the novel metrics obtained with potential practical clinical …


The Efficacy Of Analgesic Subdissociative Dose Ketamine In Trauma Casualties Treated By U.S. Military Special Operations Medical Professionals In A Prehospital Environment, Darin Schwartz Aug 2023

The Efficacy Of Analgesic Subdissociative Dose Ketamine In Trauma Casualties Treated By U.S. Military Special Operations Medical Professionals In A Prehospital Environment, Darin Schwartz

Theses & Dissertations

Research Focus. This study’s main objective was to determine the efficacy of sub-dissociative ketamine to reduce the pain of trauma casualties treated by U.S. military medical professionals in a prehospital environment evidenced by the 0–10 numeric rating scale (NRS) for pain. Research Methods. This quantitative study was accomplished using a pragmatic approach integrating social cognitive theory complemented by mixing methods using qualitative phenomenological influence through narrative inquiry. This exploratory retrospective, cross-sectional study, utilizing a quasi-experimental pretest-posttest design, used deidentified sample data (N = 47) for secondary analysis from U.S. Special Operations medical providers and were included in a casualty …


Evaluation Of Antimicrobial Stewardship For The Treatment Of Urinary Tract Infections After Pharmacist-Led Provider Education At The Center For Family Medicine, Kaylee Ayers, Faith E. Bader, Karly Blaalid, Tominee Sorenson, Sara Smith, Jennifer Ball Aug 2023

Evaluation Of Antimicrobial Stewardship For The Treatment Of Urinary Tract Infections After Pharmacist-Led Provider Education At The Center For Family Medicine, Kaylee Ayers, Faith E. Bader, Karly Blaalid, Tominee Sorenson, Sara Smith, Jennifer Ball

Pharmacy and Allied Health Professions Student Research Publications and Projects

Purpose: Urinary tract infections are a common outpatient infection, and proper antibiotic treatment is important for better patient outcomes, reducing healthcare costs, and reducing bacterial resistance. Specifically at the Center for Family Medicine (CFM), resident physicians may lack experience in prescribing proper antibiotic treatments based on patient factors for UTIs. The purpose of this study is to assess the appropriate use of antibiotics before and after a provider education pertaining to guideline recommended therapy for UTIs. The education included classifications of UTIs, first line and second line antibiotic therapy for acute uncomplicated UTIs, and first line therapy based on renal …


Use Of Electronic Health Record Reminders To Improve Primary Care Providers’ Colorectal Cancer Screening Recommendations., Terra Renee Schrembs Aug 2023

Use Of Electronic Health Record Reminders To Improve Primary Care Providers’ Colorectal Cancer Screening Recommendations., Terra Renee Schrembs

Doctor of Nursing Practice Papers

Background: Colorectal cancer (CRC) is the third most common worldwide cause of cancer morbidity and mortality. CRC mortality is preventable through regular screening. Electronic health record (EHR) reminders for providers can increase providers’ CRC screening recommendations and lead to earlier CRC diagnosis. According to the National Cancer Institute’s Screening and Risk Factors Report for Kentucky by County 2008-2010, 62.7% of adults in a rural Kentucky county aged 50-75 had completed a home based FOBT in the past two years or have ever had a colorectal endoscopy.

Purpose: The purpose of this DNP project was to implement and evaluate an …


Evaluation Of Sensory Room Education To Promote Usage In An Inpatient Psychiatric Setting: A Quality Improvement Project., Breanna M. Coulardot Aug 2023

Evaluation Of Sensory Room Education To Promote Usage In An Inpatient Psychiatric Setting: A Quality Improvement Project., Breanna M. Coulardot

Doctor of Nursing Practice Papers

Seclusion and restraints are intended to be used as a last resort intervention if a patient presents as harmful to themself or others. However, the use of seclusion and restraints in mental health practice has been questioned for several decades. A 26-year study that researched restraint-related fatalities among children and adolescents in the United States from 1993 to 2018 disclosed 79 deaths (Nunno et al., 2022). Seclusion and restraints also restrict autonomy which can cause retraumatization if a patient was previously neglected or abused (Hammer et al., 2011). Many patients presenting to the project site are survivors of neglect and …


A Program Evaluation Of Domestic Violence Screening At A Large Urban Hospital., Taylor L'Heureux Aug 2023

A Program Evaluation Of Domestic Violence Screening At A Large Urban Hospital., Taylor L'Heureux

Doctor of Nursing Practice Papers

Domestic violence has been deemed a direct invasion and violation of human rights by the World Health Organization (2021). Due to the continuous rise in cases of domestic violence, national organizations like the United States Preventative Services Task Force (USPSTF) have recommended that healthcare providers screen patients for this abuse. The purpose of this study was to reinforce the current screening procedure and protocol to ensure that each patient was screened for domestic violence before being discharged from the hospital. This study evaluated a quality improvement project formed to promote the completion of a preexisting domestic violence screening form that …


Implementation Of A Mindfulness Intervention To Increase Adolescent Resilience In An After-School Program: A Quality Improvement Project., Katie Thomas Aug 2023

Implementation Of A Mindfulness Intervention To Increase Adolescent Resilience In An After-School Program: A Quality Improvement Project., Katie Thomas

Doctor of Nursing Practice Papers

Background: Globally, fourteen percent of adolescents ages 10 to 19 years old suffer from mental health problems (World Health Organization, 2021). Resilience is a fundamental concept of the mental health promotion framework (CAMH, 2022).The WHO (2020) “Guidelines on Mental Health Promotive and Preventive Interventions for Adolescents” includes the recommendation that universal interventions to promote mental health and reduce mental disorders should include social and emotional learning (SEL), such as emotional regulation, mindfulness, stress management, problem solving, and interpersonal skills. Mindfulness-based interventions (MBIs) are one evidence-based method of accomplishing this goal (Sapthiang et al., 2018). Purpose: The purpose of …


Implementation Of An Initiative To Standardize Abdominal Binder Use In Postoperative Cesarean Section Patients: A Program Evaluation., Sarah Cohron Aug 2023

Implementation Of An Initiative To Standardize Abdominal Binder Use In Postoperative Cesarean Section Patients: A Program Evaluation., Sarah Cohron

Doctor of Nursing Practice Papers

A cesarean section is a major abdominal surgery with a unique recovery profile. The patient must recover from surgery while simultaneously coping with a major life event: the birth of a new baby. The utilization of pain management techniques with as few side effects as possible is paramount to ensure optimal maternal and newborn outcomes (Karlström et. al., 2007; Eisenach et. al., 2008). On an inpatient mother/baby unit at a high-risk urban hospital in Louisville, Kentucky approximately 66 babies are born via cesarean section every month (Mattingly, 2021). However, in the fall of 2021, it was discovered that there was …


Introduction Of A Policy Adherence Plan In An Outpatient Buprenorphine Treatment Clinic., Stacie Switzer Cheney Aug 2023

Introduction Of A Policy Adherence Plan In An Outpatient Buprenorphine Treatment Clinic., Stacie Switzer Cheney

Doctor of Nursing Practice Papers

Abstract

Background: Medication-Assisted Treatment (MAT) is one of the most effective pharmacological therapies for opioid dependence. Regular urine drug screening to include random urine drug screens at least once a month is a key factor in improving quality care for those receiving treatment in an outpatient MAT clinic.

Problem: A rural outpatient MAT clinic has a current random urine policy that is not being utilized when treating clients with Opioid Use Disorder (OUD). This increases the risk of diversion and misuse of buprenorphine/naloxone (Suboxone), thus increasing the risk of overdose and death for OUD patients.

Environment: This project was implemented …


Effects Of Preoperative Chlorhexidine Gluconate (Chg) Cloths Educational Intervention For Preoperative Staff On Chg Knowledge And Surgical Site Infection Rates: A Quality Improvement Initiative., Deven Leffler Aug 2023

Effects Of Preoperative Chlorhexidine Gluconate (Chg) Cloths Educational Intervention For Preoperative Staff On Chg Knowledge And Surgical Site Infection Rates: A Quality Improvement Initiative., Deven Leffler

Doctor of Nursing Practice Papers

Abstract

Background: Surgical site infections (SSIs) are the most common cause of a surgical complication and account for 38% of all hospital acquired infections (HAI). The cost of caring for SSIs in the United States can range from $3.5-$10 billion annually.

Purpose: The purpose of this DNP Quality Improvement (QI) initiative was to improve preoperative staff’s knowledge and application of the Food and Drug Administration (FDA) approved 3-minute application scrub time for the 2% CHG cloths and reduce SSIs for an acute care hospital located in Louisville, Kentucky.

Methods: Quality improvement was initiated using the Plan, Do, Study, Act (PDSA) …


Schedule: Pre-Health Seminar Series 2023-24, University Of Dayton Aug 2023

Schedule: Pre-Health Seminar Series 2023-24, University Of Dayton

Pre-Health Resource Center Campus Communications

No abstract provided.


Causal Inference Methods For Estimation Of Survival And General Health Status Measures Of Alzheimer’S Disease Patients, Ehsan Yaghmaei Aug 2023

Causal Inference Methods For Estimation Of Survival And General Health Status Measures Of Alzheimer’S Disease Patients, Ehsan Yaghmaei

Computational and Data Sciences (PhD) Dissertations

Identifying optimal treatment options with respect to survival of Alzheimer's disease patients is crucially important and previously uninvestigated research question. Our objective was to estimate the causal effects of the most prevalent classes of Alzheimer’s disease drugs, Donepezil and Memantine, and their combined use on Survival and General Health Status Measures of Alzheimer's disease patients for the first five years after initial diagnosis. We carried out a thorough causal inference study using doubly robust estimators, nonparametric bootstrap confidence intervals, Bonferroni corrections for multiple comparisons and analyzing one of the largest high-quality medical databases containing millions of de-identified electronic health records …


A Consensus Panel Approach To Estimating The Start-Up And Annual Service Costs For Rural Ambulance Agencies, Yvonne Jonk Phd, Gary Wingrove Facpe, Cp-C, Nikiah Nudell Ms, Mphil, Nrp, Facpe, Kevin Mcginnis Mps Aug 2023

A Consensus Panel Approach To Estimating The Start-Up And Annual Service Costs For Rural Ambulance Agencies, Yvonne Jonk Phd, Gary Wingrove Facpe, Cp-C, Nikiah Nudell Ms, Mphil, Nrp, Facpe, Kevin Mcginnis Mps

Emergency Medical Services (EMS)

This brief serves to fill the information void on the costs of running ambulance services for three population-based service tiers and establishes a minimum access standard for ambulances servicing a 25-minute travel time radius from the ambulance station. The model enables policymakers and community stakeholders to develop strategic plans for the financing and provision of ambulance services. Key Highlights: An expert panel established that ambulances could reasonably serve a maximum 25-minute travel time from the ambulance station that accounts for road conditions. A minimum access standard was defined as a single resource consisting of one full-time staffed ambulance, with a …


The Structural Characterization And Bioactivity Assessment Of Nonspecific Lipid Transfer Protein 1 (Nsltp1) From Caraway (Carum Carvi) Seeds, Taibah Aldakhil Aug 2023

The Structural Characterization And Bioactivity Assessment Of Nonspecific Lipid Transfer Protein 1 (Nsltp1) From Caraway (Carum Carvi) Seeds, Taibah Aldakhil

Pharmaceutical Sciences (PhD) Dissertations

Background: Carum carvi (caraway) of the Apiaceae family has been used in many cultures as a cooking spice and part of the traditional medicine. Previous reports primarily focus on the medicinal properties of caraway seed essential oil and the whole seeds extract. However, no effort has been made to study caraway proteins and their potential pharmacological properties, including nonspecific lipid transfer protein (nsLTP), necessitating further research. The current study aimed to characterize nonspecific lipid transfer protein 1 (nsLTP1) from caraway seed, determine its three-dimensional structure, and analyze protein-ligand complex interactions through docking studies. Also, evaluate nsLTP1 in vitro cytotoxic …


The Scoop, Vol. 10 Issue 5, August 2023, Health Sciences Library Aug 2023

The Scoop, Vol. 10 Issue 5, August 2023, Health Sciences Library

Volume 10

Latest news and updates from the Health Sciences Library in our monthly newsletter for August 2023.


Wellness And The Occupational Impact Of Being A Police Officer, Daisy Nunez, Karen Park Aug 2023

Wellness And The Occupational Impact Of Being A Police Officer, Daisy Nunez, Karen Park

Summer 2023 Virtual OTD Capstone Symposium

The occupational impact of being a police officer was researched. Along with the barriers and supports to wellness services. The study aimed to answer both those questions to analyze the impact of wellness on the population.


From Myzocytosis To Cytostomal Nutrient Uptake And Transport By Intracellular Plasmodium Species, T. Y. Sam-Yellowe Aug 2023

From Myzocytosis To Cytostomal Nutrient Uptake And Transport By Intracellular Plasmodium Species, T. Y. Sam-Yellowe

Biological, Geological, and Environmental Faculty Publications

No abstract provided.


The Impact Of Social Determinants Of Health And Acculturation On Quality Of Life In Older Chinese American Adults With Chronic Pain: A Quantitative Study, Chi Lam Aug 2023

The Impact Of Social Determinants Of Health And Acculturation On Quality Of Life In Older Chinese American Adults With Chronic Pain: A Quantitative Study, Chi Lam

Dissertations

Despite a rapid increase in the older Chinese American adult population, there are very few research studies examining the impact of social determinants of health and acculturation on the quality of life in older Chinese American adults. The purpose of the study was to determine the impact of social determinants of health and acculturation on quality of life in older Chinese American adults with chronic pain. This quantitative, descriptive correlational study utilized Madeleine Leininger’s Transcultural Theory as its theoretical framework. Two research questions guided this study: (1) Was there a difference in the quality of life in older Chinese American …


Paradoxical Tumor Necrosis Factor-Alpha (Tnf-Α) Inhibitor-Induced Psoriasis: A Systematic Review Of Pathogenesis, Clinical Presentation, And Treatment., Aditi Chokshi, Michelle Demory Beckler, Anita Laloo, Marc M. Kesselman Aug 2023

Paradoxical Tumor Necrosis Factor-Alpha (Tnf-Α) Inhibitor-Induced Psoriasis: A Systematic Review Of Pathogenesis, Clinical Presentation, And Treatment., Aditi Chokshi, Michelle Demory Beckler, Anita Laloo, Marc M. Kesselman

HPD Articles

Tumor necrosis factor-alpha (TNF-α) inhibitors have been shown to be well tolerated among patients with rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Meanwhile, more recently, clinical practice and research efforts have uncovered increasing cases of psoriatic lesion development tied to initiating treatment with a TNF-α inhibitor. The underlying mechanisms associated with this occurrence have yet to be fully elucidated. A review and analysis of cases of paradoxical psoriasis currently published in the literature is warranted. In addition, exploring possible mechanisms of action and potential treatment options associated with favorable outcomes is much needed. A systematic literature review was performed utilizing …


Improving Central Line-Associated Bloodstream Infection Prevention Bundle Compliance To Reduce Infection Rates In A Pediatric Cardiac Intensive Care Unit., Aubree Croghan Aug 2023

Improving Central Line-Associated Bloodstream Infection Prevention Bundle Compliance To Reduce Infection Rates In A Pediatric Cardiac Intensive Care Unit., Aubree Croghan

Doctor of Nursing Practice Papers

Background: Central line-associated bloodstream infection (CLABSI) is the most common healthcare-acquired infection in pediatrics. A pediatric acute care facility in Kentucky created a specialized care team in an effort to track CLABSI bundle compliance and reduce central line infections. While rates of infection decreased, a significant number of infections still occurred and staff adherence to facility evidence-based policies and infection prevention interventions remained low.

Purpose: To reach the facility’s goal of zero central line-associated bloodstream infections, a quality improvement (QI) project was developed to improve staff knowledge of care and increase staff adherence to policy.

Methodology: To create the QI …


Improving Prediabetes Screening, Diagnosis, And Referral To A Diabetes Prevention Program In The Primary Care Setting., Brittany Morguelan Aug 2023

Improving Prediabetes Screening, Diagnosis, And Referral To A Diabetes Prevention Program In The Primary Care Setting., Brittany Morguelan

Doctor of Nursing Practice Papers

Improving Prediabetes Screening, Diagnosis, and Referral to a Diabetes Prevention Program in the Primary Care Setting

Table of Contents

Abstract……………………………………………………………………………………………4

Background………………………………………………………………………………………..5

Purpose…………………………………………………………………………………………...10

Literature Review……………………………………………………………………………...…10

Conceptual Framework…………………………………………………………………………..15

Setting………………………………………………………………………………………...….17

Context…………………………………………………………………………………………..18

Procedures/Intervention…….……………………………………………………………………19

Ethical Considerations…..……………………………………………………………………….20

Measures…………………………………………………………………………………………20

Data Analysis……………………………………………...……………………………………..22

Results……………………………………………………………………………………………23

Discussion……………………………………………………………………………...………...26

References……………………………………………………………………………………….33

Appendix A: Implementation Timeline…………………………………………………………40

Appendix B: IROC Quality Improvement Leadership Approval Letter………………………...41

Appendix C: PCP Referral Process and Diabetes Prevention Program Referral Order………...42

Figure 1: Monthly Number of N-DPP EHR Referrals by PCPs…………………………………….43

Figure 2: Monthly Total PCP Screening HbA1c/FBG Orders vs. Monthly Results HbA1cs……44

Figure 3: Demographic Analysis: Patients with a Documented Prediabetes ICD-10 (R73.03/R73.0)………………………………………………………………………………………….45

Abstract

Background: Prediabetes is a …


Utilizing A Reminder Tool To Improve Post-Hypoglycemia Recheck Rates On A Medical Surgical Unit., Laken Heitz Aug 2023

Utilizing A Reminder Tool To Improve Post-Hypoglycemia Recheck Rates On A Medical Surgical Unit., Laken Heitz

Doctor of Nursing Practice Papers

Diabetes is a growing epidemic with profound implications on the healthcare system. One of many possible complications is hypoglycemia, which is any value below 70 mg/dL. Inpatient hypoglycemia is a patient safety concern, and its treatment requires nursing adherence to strict protocols including a recheck within 15 to 30 minutes after treatment. However, evidence from the literature and project site demonstrated low rates of timely post-hypoglycemia rechecks. The purpose of this project was to provide education to all MIPS nurses regarding the utilization of a reminder tool for post-hypoglycemia rechecks. The intervention plan included reviewing the current hospital-wide hypoglycemia policy, …


Remote Blood Pressure Monitoring Program: Program Evaluation., Brittany Walker Aug 2023

Remote Blood Pressure Monitoring Program: Program Evaluation., Brittany Walker

Doctor of Nursing Practice Papers

The prevalence of hypertension is high at the local, state, and national levels. In 2021, 39% of Kentucky adults were diagnosed with high blood pressure (CDC, 2021). Primary care providers are utilizing remote blood pressure monitoring (RBPM) to assist with the management of hypertension. Literature reveals that remote BP monitoring alone, without the use of other interventions such as counseling and education, may not effectively control blood pressure (Uhlig K, et al, 2013). This project evaluated the RBPM program utilized at a federally qualified health center in Louisville, KY. Patient engagement within the RBPM program includes BP measurement, communication with …


A Quality Improvement Project: Implementing Safe Sleep Practice In A Neonatal Intensive Care Unit., Morgan Demyer Aug 2023

A Quality Improvement Project: Implementing Safe Sleep Practice In A Neonatal Intensive Care Unit., Morgan Demyer

Doctor of Nursing Practice Papers

Significance: The American Academy of Pediatrics (AAP) recommends safe sleep practices (SSP) to reduce infant sleep-related deaths. Annually 3,500 babies die due to improper sleeping conditions, and Kentucky is among the lower-performing states for infant sleep safety. The AAP recommends initiating SSP with infants in neonatal intensive care units (NICU) and recently expanded recommendations in 2022. Presently, there is no regulation of healthcare clinician education regarding SSP or role-modeling behavior in the in-patient setting.

Purpose: This scholarly project aimed to improve knowledge and awareness of SSP by improving clinician knowledge and behavior of SSP use in NICU and …


N Y State Dent J August-September 2023 Aug 2023

N Y State Dent J August-September 2023

The New York State Dental Journal

In the August-September 2023 issue, the reader will find the following feature articles:

    • Iatrogenic Indirect Compression of the Inferior Alveolar Nerve by a Dental Implant
    • Use of Dentoalveolar and Zygomatic Implants in Restoration of Maxillary Defect Following Fibula Free-flap Reconstruction Failure
    • Flapless Approach to Dental Implant Surgery: To Use or Not to Use?

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.


Reaction Time Under Limited Vision With Cognitive Challenge In Individuals With Anterior Cruciate Ligament Reconstruction, Hsuan Bonny Lu Aug 2023

Reaction Time Under Limited Vision With Cognitive Challenge In Individuals With Anterior Cruciate Ligament Reconstruction, Hsuan Bonny Lu

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The anterior cruciate ligament (ACL) rupture is a common sports injury. ACL reconstruction (ACLR) is a necessary treatment for individuals to return to competitive sports. However, a high rate of secondary injury occurs when individuals return to sport. Past research has shown that ACLR impairs physical performance, including reduction of force generate against the floor under the injured leg, changes in the gait pattern, and a loss of knee stability. While structural changes following ACL injury can leave the knee joint less stable, neurophysiological changes following ACL injury represent one potentially important mechanism underlying the performance deficits. Healthy individuals rely …


New Dentist News (August 2023), Ada Committee On The New Dentist Aug 2023

New Dentist News (August 2023), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.


Enhancing Adherence To Best Practice Guidelines Related To Pressure Injury Prevention In The Operating Room At A Children's Hospital During Comprehensive Dental Procedures., Alyce Bailey Seaver Aug 2023

Enhancing Adherence To Best Practice Guidelines Related To Pressure Injury Prevention In The Operating Room At A Children's Hospital During Comprehensive Dental Procedures., Alyce Bailey Seaver

Doctor of Nursing Practice Papers

Background: 1,600,000 patients develop a hospital-acquired pressure injury every year, and 23% of these originate during surgery. Research has demonstrated that the incidence of hospital-acquired pressure injuries developing during surgery has risen over the past 5 years. This rise has been attributed to nurse circulators exhibiting poor knowledge regarding best practices for intraoperative patient positioning and intraoperative documentation that does not follow standards of care.

Purpose: This quality improvement project aimed to enhance circulator knowledge on best practices for intraoperative patient positioning and improve documentation of intraoperative patient positioning in the electronic medical record to comply with standards of …


Monitoring, Prophylaxis, And Treatment Of Infections In Patients With Mm Receiving Bispecific Antibody Therapy: Consensus Recommendations From An Expert Panel., Noopur Raje, Kenneth Anderson, Hermann Einsele, Yvonne Efebera, Francesca Gay, Sarah P Hammond, Alexander M Lesokhin, Sagar Lonial, Heinz Ludwig, Philippe Moreau, Krina Patel, Karthik Ramasamy, Maria-Victoria Mateos Aug 2023

Monitoring, Prophylaxis, And Treatment Of Infections In Patients With Mm Receiving Bispecific Antibody Therapy: Consensus Recommendations From An Expert Panel., Noopur Raje, Kenneth Anderson, Hermann Einsele, Yvonne Efebera, Francesca Gay, Sarah P Hammond, Alexander M Lesokhin, Sagar Lonial, Heinz Ludwig, Philippe Moreau, Krina Patel, Karthik Ramasamy, Maria-Victoria Mateos

Oncology Articles

Bispecific antibodies (BsAbs) are emerging as an important novel class of immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be more widely used in clinical practice. However, this new class of therapies is associated with a distinct adverse event (AE) profile that includes cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, as well as AEs leading to increased infection risk such as cytopenias and hypogammaglobulinemia, and infections themselves. As preliminary data with this class of agents shows an increased risk of infections as compared with conventional MM treatment regimens, such as immunomodulatory drugs, proteasome …