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Full-Text Articles in Medicine and Health Sciences

Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff Apr 2026

Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff

Faculty Publications

Background

Mediation analyses provide insight into both ‘pieces’ of the mediation chain; they allow us to look into the ‘black box’ that is behavior change. They allow researchers to better understand the ‘how’ of an intervention’s effects and/or the ‘why’ behind why an intervention worked or did not work. The lack of publications in pregnant populations highlights the need for additional studies to be conducted and published. The purpose of this study is to examine the psychosocial mediators of physical activity and dietary outcomes in a sample of pregnant women with overweight or obesity participating in the Health in Pregnancy …


Plastics, Microplastics, And The Gut Microbiome: Restoring Scientific Communication To Fight For Public Health, Benjamin Sanders '26 Apr 2026

Plastics, Microplastics, And The Gut Microbiome: Restoring Scientific Communication To Fight For Public Health, Benjamin Sanders '26

Honor Scholar Theses

Over the course of eight years from 2016 to 2024, a study by Nature Medicine found that the concentration of plastics in the brain increased by 50%. Even samples from patients with a documented dementia diagnosis showed a greater accumulation of microplastics (Nihart, 2025). In one of the most protected regions of our body, microplastics have made themselves known. In one of the most exposed regions of the human body, the story is no different. With the emergence of gut microbiome science and understanding, researchers are just beginning to discover the unique interplay between the microbiota of our gastrointestinal tract …


Cardiomyopathy In Children: What Pediatricians Need To Know, Michael Smith, Brian Birnbaum Apr 2026

Cardiomyopathy In Children: What Pediatricians Need To Know, Michael Smith, Brian Birnbaum

Pediatrics in Practice: A CME Podcast

Cardiomyopathy in children can present with subtle signs but serious consequences if missed. In this episode, Brian Birnbaum, MD, Interim Co-Director of the Ward Family Heart Center at Children’s Mercy, shares practical insights for pediatricians on recognizing early red flags, knowing when to refer, and understanding how diagnosis and management of pediatric cardiomyopathy are evolving.

Click here to stream the podcast episode.


Quality Improvement Project: Educating Nursing Faculty On Animal-Assisted Therapy: Enhancing Knowledge And Confidence To Improve Program Outcomes, Sarah J. Whitwell Apr 2026

Quality Improvement Project: Educating Nursing Faculty On Animal-Assisted Therapy: Enhancing Knowledge And Confidence To Improve Program Outcomes, Sarah J. Whitwell

Doctor of Nursing Practice Projects

The purpose of this quality improvement project was to evaluate whether an educational intervention on animal-assisted therapy (AAT) improved nursing faculty perceived knowledge and confidence in using AAT to improve program outcomes. The problem addressed was the limited knowledge and confidence among nursing faculty regarding the use of non-traditional, evidence-based strategies to support student mental health. This project was guided by the Stetler Model of Evidence-Based Practice and Lewin’s Change Theory and used a quasi-experimental, one-group pre–post design. The project was conducted with nursing faculty teaching in a baccalaureate program at a four-year public university in Oklahoma. A 10-item Likert-scale …


Facilitators And Barriers To Mobile Health Unit Implementation: A Qualitative-Dominant Mixed Methods Study Exploring Staff Perspectives And Service Outreach, Kelsey Hardin Apr 2026

Facilitators And Barriers To Mobile Health Unit Implementation: A Qualitative-Dominant Mixed Methods Study Exploring Staff Perspectives And Service Outreach, Kelsey Hardin

MUSC Theses and Dissertations

Background: Health disparities are linked to rising healthcare costs in the United States, particularly related to healthcare accessibility. Mobile Health Units (MHUs) have proven to be an effective intervention in reducing barriers to healthcare services, for example, providing early access to prenatal care, thus reducing infant mortality rates. This study focused on the facilitators and barriers to implementing an MHU program, based on staff perspectives and service outreach, to improve maternal and infant health outcomes.

Methods: This study employed a qualitative-dominant mixed-methods research design. Data was collected through interviews to assess staff perspectives. Secondary data analysis of quantitative data was …


Good Neighbor Physician Gives Distinguished Service To Fsu, Kathy Whitlock Apr 2026

Good Neighbor Physician Gives Distinguished Service To Fsu, Kathy Whitlock

Documents

DR. T.L. Bennett, Jr. and his service to the university as university physician--The Flor-Ala


Roy Stevens Hall Dedicated, Vincent Toney Apr 2026

Roy Stevens Hall Dedicated, Vincent Toney

Documents

Dedication of the Education/Nursing building as Roy Stevens Hall--The TimesDaily


A Blueprint For Success, Una Publications Office Apr 2026

A Blueprint For Success, Una Publications Office

Documents

Brochure for the Education-Nursing Building at UNA


La Dolce Vita Or The American Way: A Comparative Study Into The Italian And American Healthcare Systems Through An Analysis Of Total Knee Replacements, James (Jim) Mcmurray '26 Apr 2026

La Dolce Vita Or The American Way: A Comparative Study Into The Italian And American Healthcare Systems Through An Analysis Of Total Knee Replacements, James (Jim) Mcmurray '26

Honor Scholar Theses

This thesis presents a comparative study of the Italian and the American healthcare systems, using Total Knee Replacements (TKRs) as a standardized metric to evaluate the health policy, financing, and patient outcomes. Despite the United States spending over $10,000 more per capita on healthcare than Italy, American life expectancy is 5 years shorter than Italian life expectancy. Through a mixed-methods analysis of data from the American Joint Replacement Registry (AJRR), the Programma Nazionale Esiti (PNE), the Registri Italiani di ArtoProtesi (RIAP), and the HCUPnet (AHRQ) database, this research identifies multiple disparities throughout the system. Key findings in this thesis include …


Developing Nursing Education On The Assessment Of Asthma Patients With Symptoms Of Shortness Of Breath In Urgent Care, Abigail Akorfa Adase Apr 2026

Developing Nursing Education On The Assessment Of Asthma Patients With Symptoms Of Shortness Of Breath In Urgent Care, Abigail Akorfa Adase

Walden Dissertations and Doctoral Studies

This quality improvement project aimed to enhance the assessment of dyspnea in patients presenting with shortness of breath, particularly those with asthma, through a staff education program. At the practice site, staff primarily relied on SpO₂ readings to evaluate dyspnea, which often led to misassessment and delays in care. The project addressed this gap by providing urgent care staff with training on comprehensive assessment techniques, including evaluation of respiratory rate, work of breathing, ability to speak, patient history, and use of validated tools such as Borg’s scale and peak flow meters. Twenty triage staff members participated, including licensed practical nurses, …


Fast-Food Consumption And Metabolic Syndrome Risk In African Children And Adolescents, Norkinsha Willis Apr 2026

Fast-Food Consumption And Metabolic Syndrome Risk In African Children And Adolescents, Norkinsha Willis

Walden Dissertations and Doctoral Studies

Childhood obesity and excessive fast-food intake represent a significant public health concern among African American children. Grounded in the social-ecological model, this quantitative, cross-sectional study examined whether frequency of fast-food or pizza meal consumption and reliance on low-cost food was associated with total cholesterol (mg/dL) and waist circumference among African American children and adolescents aged 6–15 years while controlling for key sociodemographic factors (age, gender, parental education status, and annual household income). Secondary data from the 2017–2018 National Health and Nutrition Examination Survey were analyzed (N=184). Descriptive statistics, nonparametric analyses, and a multiple linear regression model were used to analyze …


Analysis Of Stance Position On The Accuracy Of Forehand And Backhand Strokes In Beginner Table Tennis Players, Azzahra Julia Putri Anjani, Mochamad Yamin Saputra, Geraldi Novian Apr 2026

Analysis Of Stance Position On The Accuracy Of Forehand And Backhand Strokes In Beginner Table Tennis Players, Azzahra Julia Putri Anjani, Mochamad Yamin Saputra, Geraldi Novian

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: This study was motivated by the low accuracy of forehand and backhand strokes among beginner table tennis players, which is due to unstable stance positions and poor balance during ball striking. Objective: This study aims to analyze the relationship between stance position and the accuracy of forehand and backhand strokes among beginner table tennis players. Methods: This study used a descriptive correlational design with 7 beginner table tennis athletes. The research instruments were forehand and backhand accuracy tests using the multiball method and stance position analysis through video recordings, analyzed using the Kinovea application. Data analysis was performed using …


Development And Evaluation Of An Iot-Based Data Analytics System For Optimizing Football Learning In Higher Education, M. Said Zainuddin, Sudirman Sudirman, Ahmad Zakaria Apr 2026

Development And Evaluation Of An Iot-Based Data Analytics System For Optimizing Football Learning In Higher Education, M. Said Zainuddin, Sudirman Sudirman, Ahmad Zakaria

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: While smart technology and big data have advanced, football instruction at Indonesian universities lags. Most local classrooms lack high-tech tools, presenting an opportunity to modernize sports science. Objective: This research aimed to develop an IoT-based system and analytics platform for higher education, equipping students and coaches with data-driven insights for modern football training. Methods: Conducted at Universitas Negeri Makassar over five months (August–December), the study followed a Research and Development approach with six phases: needs analysis, design, development, expert validation, field trials, and effectiveness evaluation. Participants included Physical Education students divided into experimental (IoT system) and control (traditional methods) …


Cardiovascular Adaptation To Whole-Body Vibration Exercise In Obese Young Adults: A Systematic Review, Meta-Analysis, And Exploratory Analysis Of Sex Differences, Rafiu Okuneye, Abdulkareem Taiwo, Fatai Akinola Apalara, Okechukwu Kingsley Oforka, Isaiah Whenayon Ajoseh, Ogar Emmanuel Ekawu Apr 2026

Cardiovascular Adaptation To Whole-Body Vibration Exercise In Obese Young Adults: A Systematic Review, Meta-Analysis, And Exploratory Analysis Of Sex Differences, Rafiu Okuneye, Abdulkareem Taiwo, Fatai Akinola Apalara, Okechukwu Kingsley Oforka, Isaiah Whenayon Ajoseh, Ogar Emmanuel Ekawu

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Obesity is strongly associated with hypertension and autonomic dysfunction. Whole-body vibration exercise (WBVE) has been proposed as a low-impact intervention for improving cardiovascular function in obese adults, but sex-specific responses remain unclear. Objective: This study aimed to evaluate the effects of whole-body vibration exercise on blood pressure, autonomic function, and cardiac output in adults with obesity, and to explore potential sex differences in cardiovascular adaptations. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials and quasi-experimental studies examining the effects of WBV on systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate variability (HRV), and …


Physical Fitness, Body Mass Index, And Physical Activity Among Senior Secondary Students: A Cross-Sectional Study In An Indonesian Islamic Secondary School, Ilona Pratiwi Hutabarat, Acep Rohmat Nurhidayat, Aprizal Fikri, Teguh Andi Prabowo, I Bagus Endrawan Apr 2026

Physical Fitness, Body Mass Index, And Physical Activity Among Senior Secondary Students: A Cross-Sectional Study In An Indonesian Islamic Secondary School, Ilona Pratiwi Hutabarat, Acep Rohmat Nurhidayat, Aprizal Fikri, Teguh Andi Prabowo, I Bagus Endrawan

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Physical fitness is a fundamental component of adolescent health and contributes to academic performance, mental well-being, and lifelong health outcomes. Following the COVID-19 pandemic and the rise in sedentary behavior, evidence on the fitness profiles of Indonesian senior secondary students—particularly in Islamic secondary schools (Madrasah Aliyah)—remains scarce. Objective: To assess the physical fitness level of Madrasah Aliyah students and to examine its association with body mass index (BMI) and self-reported physical activity. Methods: A cross-sectional survey was conducted among 35 students (18 male, 17 female; aged 15–19 years) at MA Raudlatul Irfan, South Tangerang, using purposive sampling. Physical fitness …


The Influence Of Lower-Body Explosive Power, Speed, And Eye-Foot Coordination On Long Jump Performance: A Path Analysis Study, Alwi Fahruzy Nasution, Imanuddin Siregar Apr 2026

The Influence Of Lower-Body Explosive Power, Speed, And Eye-Foot Coordination On Long Jump Performance: A Path Analysis Study, Alwi Fahruzy Nasution, Imanuddin Siregar

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Long jump performance is influenced by various physical and coordinative components, particularly lower-body explosive power, running speed, and eye-foot coordination. However, limited studies have simultaneously examined the predictive relationships among these variables using a path analysis model among university students in physical education programs. Objective: This study aimed to analyze the direct and indirect predictive relationships among lower-body explosive power, speed, eye-foot coordination, and long jump performance. Methods: This study employed a quantitative, cross-sectional, correlational design with path analysis. The sample consisted of 30 students selected using a total sampling technique. Data were collected using standardized physical performance tests, …


Dietary Patterns And Nutritional Status In Soccer Athletes: A Cross-Sectional Study From An Ergonomic Perspective, Rina Mayangsari, Ravi Masitah Apr 2026

Dietary Patterns And Nutritional Status In Soccer Athletes: A Cross-Sectional Study From An Ergonomic Perspective, Rina Mayangsari, Ravi Masitah

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Normal nutritional status has been established as one of the principal determinants in an athlete's performance. Dietary quality plays a critical role in optimizing athletes' physical fitness and performance outcomes. Objective: To examine the associations between dietary patterns on the MacPersona System and nutritional status of soccer players (energy, protein, et cetera, fat, and carbohydrates). Methods: A cross-sectional quantitative study was conducted involving 21 soccer players (total sampling). Dietary patterns were assessed using a validated Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ). Nutritional status was measured using Body Mass Index(BMI) based on anthropometric data. The chi-square test was used for statistical …


Development And Validation Of A Basic Skill-Based Swimming Training Model For Beginner Athletes: An Addie Approach, Martinus Martinus, Hilmy Aliriad, Karmila Utari, I Bagus Endrawan, Muhamad Rohadi Apr 2026

Development And Validation Of A Basic Skill-Based Swimming Training Model For Beginner Athletes: An Addie Approach, Martinus Martinus, Hilmy Aliriad, Karmila Utari, I Bagus Endrawan, Muhamad Rohadi

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Mastery of basic swimming skills is foundational for the development of beginner athletes, yet structured, validated training models tailored to the Indonesian context remain scarce. Objective: This study aims to develop a basic skill-based swimming training model that is content-valid, practical, and effective in improving swimming technical ability in beginner athletes aged 8-12 years, through systematic, staged development procedures. Methods: The research used the Research and Development (R&D) ADDIE model approach with staged procedures: (1) drafting the initial model based on needs analysis, (2) expert validation by four active swimming coaching validators using the Content Validity Ratio (CVR) instrument …


Global Trends And Research Directions Of Augmented Reality In Sports: A Bibliometric And Scoping Review, Novri Gazali, Ahmad Rahmadani, Romi Cendra, M. Fransazeli Makorohim, Syed Kamaruzaman Syed Ali, Joseph Lobo, Edi Setiawan Apr 2026

Global Trends And Research Directions Of Augmented Reality In Sports: A Bibliometric And Scoping Review, Novri Gazali, Ahmad Rahmadani, Romi Cendra, M. Fransazeli Makorohim, Syed Kamaruzaman Syed Ali, Joseph Lobo, Edi Setiawan

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Advances in digital technology have accelerated the adoption of augmented reality (AR) in sports, enhancing training quality, performance analysis, and learning experiences. However, comprehensive studies that systematically map global research trends and sport-specific applications remain limited. Objective: This study aims to analyze global trends and applications of augmented reality (AR) in sports using a mixed-method approach combining bibliometric analysis and a scoping review. Methods: Bibliographic data were retrieved from Scopus and Web of Science (WoS) databases, covering the period 2016–2025. Following a PRISMA-ScR-based selection process, a total of 520 articles were included. Bibliometric analysis was conducted using VOSviewer and …


Improving Academic Learning Time Effectiveness Through Lesson Study In Elementary Physical Education, Nora Antika, Meirizal Usra, Wahyu Indra Bayu, Iyakrus Iyakrus, Herri Yusfi, Arizky Ramadhan, Asha Hasnimy Mohd Hashim, Japhet Ndayisenga, José Vicente García-Jiménez Apr 2026

Improving Academic Learning Time Effectiveness Through Lesson Study In Elementary Physical Education, Nora Antika, Meirizal Usra, Wahyu Indra Bayu, Iyakrus Iyakrus, Herri Yusfi, Arizky Ramadhan, Asha Hasnimy Mohd Hashim, Japhet Ndayisenga, José Vicente García-Jiménez

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Academic Learning Time in Physical Education (ALT-PE) is a key indicator of instructional effectiveness, reflecting the time students spend actively engaged in meaningful learning activities. However, PE lessons often involve excessive Management and waiting time, reducing opportunities for active participation. Although Lesson Study (LS) is recognized as a collaborative professional development approach that can improve instructional quality, its impact on ALT-PE remains underexplored. Objective: This study examined the effectiveness of Lesson Study (LS) in improving instructional effectiveness and optimizing ALT-PE among elementary school PE teachers. Methods: A qualitative-dominant mixed-methods action research design was employed involving 10 PE teachers from …


Cardiorespiratory Fitness In Indonesian Adolescents: Limited Role Of Bmi And Dominant Influence Of Age And Sex In A Large Cross-Sectional Study, Anies Setiowati, Sri Sumartiningsih, Nur Ilhaini Sucipto, Fatih Hazar, Philip X. Fuchs Apr 2026

Cardiorespiratory Fitness In Indonesian Adolescents: Limited Role Of Bmi And Dominant Influence Of Age And Sex In A Large Cross-Sectional Study, Anies Setiowati, Sri Sumartiningsih, Nur Ilhaini Sucipto, Fatih Hazar, Philip X. Fuchs

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Cardiorespiratory fitness (CRF) is a crucial indicator of long-term cardiovascular and metabolic health. Whether body mass index (BMI) independently predicts CRF beyond demographic factors in large, real-world adolescent cohorts remains inconsistently defined. Objective: To determine the independent contributions of body mass index (BMI), age, and sex to cardiorespiratory fitness among Indonesian adolescents using a large community-based dataset.. Methods: A cross-sectional study was conducted using community-based fitness screening data from Central Java, Indonesia. A total of 2,730 adolescents aged 10-18 years (mean 13.3 +/- 2.2 years; 49.6% male) were included. The primary outcome was CRF measured by the 1,600-meter run …


Association Between Eating Disorders, Macronutrient Intake Levels, And Muscle Mass Percentage Among University Martial Arts Athletes, Emyr Reisha Isaura, Kinasih Josephine Gusti Wiyarso, Lindsay Ozora Sanyaezra Simanjuntak, Amanda Humaira Febriyanti, Sekar Arum Kinasih, Sri Sumartinigsih Apr 2026

Association Between Eating Disorders, Macronutrient Intake Levels, And Muscle Mass Percentage Among University Martial Arts Athletes, Emyr Reisha Isaura, Kinasih Josephine Gusti Wiyarso, Lindsay Ozora Sanyaezra Simanjuntak, Amanda Humaira Febriyanti, Sekar Arum Kinasih, Sri Sumartinigsih

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Combat sport athletes often engage in rapid weight-management practices that may increase the risk of disordered eating and inadequate nutritional intake, potentially affecting muscle mass and athletic performance. However, evidence regarding the relationship between eating disorder risk, macronutrient intake, and muscle mass among university martial arts athletes remains limited. Objective: This study examined the association between eating disorder risk and macronutrient intake with muscle mass among martial arts student club members at Universitas Airlangga. Methods: A cross-sectional study was conducted among 60 university students (≥18 years) selected through stratified random sampling from martial arts student activity clubs. Eating disorder …


The Relationship Between Macronutrient Intake And Cardiometabolic Indicators In College Students Who Regularly Exercise, Yosef Ferdy Yangkara, Akhmad Lutfi, Bagus Kusuma Putra, Siti Baitul Mukarromah, Adi S Apr 2026

The Relationship Between Macronutrient Intake And Cardiometabolic Indicators In College Students Who Regularly Exercise, Yosef Ferdy Yangkara, Akhmad Lutfi, Bagus Kusuma Putra, Siti Baitul Mukarromah, Adi S

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Macronutrient intake plays a crucial role in determining body composition and cardiovascular health. Studies that simultaneously examine macronutrient intake and various cardiometabolic indicators in physically active populations without a clinical history remain limited. Objective: This study aims to analyze the relationship between macronutrient intake and BMI, blood pressure, and heart rate among a gymnastics community at Semarang State University. Methods: The study used a cross-sectional design involving 30 students (12 males and 18 females) aged 18–35 years, selected through purposive sampling. Macronutrient intake data were collected using a 2×24-hour food recall method, while BMI, blood pressure, and heart rate …


Body Composition Profiles And Physical Readiness Among Paragliding Trainees: A Cross-Sectional Study, Nanang Indardi, Anies Setiowati, Fajar Syamsudin, Didik Cahyono, Johnlenon Aliser, Sangheon Park Apr 2026

Body Composition Profiles And Physical Readiness Among Paragliding Trainees: A Cross-Sectional Study, Nanang Indardi, Anies Setiowati, Fajar Syamsudin, Didik Cahyono, Johnlenon Aliser, Sangheon Park

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Physical readiness is essential for performance and safety in paragliding. Body composition has been recognized as an important factor associated with physical performance; however, evidence regarding its collective influence on physical readiness among paragliding trainees remains limited. Objective: This study aimed to examine the role of body composition as an integrated correlate of physical readiness among paragliding trainees using a multiple regression analysis. Methods: A quantitative cross-sectional study was conducted involving 24 paragliding trainees selected through purposive sampling. Body composition variables, including body mass index (BMI), body fat percentage (PBF), skeletal muscle mass (SMM), and basal metabolic rate (BMR), …


Analysis Of Rule Violations Leading To Disqualification In Youth Swimming Competitions: Evidence From Indonesia, Ika Novitaria Marani, Ari Subarkah, Heni Widyaningsih, Ricky Susiono, Muhammad Syahrul Ramadhan Apr 2026

Analysis Of Rule Violations Leading To Disqualification In Youth Swimming Competitions: Evidence From Indonesia, Ika Novitaria Marani, Ari Subarkah, Heni Widyaningsih, Ricky Susiono, Muhammad Syahrul Ramadhan

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: The purpose of this study was to determine how disqualifications of competition rules in swimming competitions are committed. Rules must be obeyed when competing, and there are consequences for swimmers who violate them. Objective: To find out how the disqualification of the rules of the competition game in the swimming sport is carried out in the swimming competition. Methods: The research was conducted at the GBK Senayan Swimming Pool, and the study used a descriptive observational design. The population in this study consists of all beginner-level swimmers who take part in the 2025 DKI Jakarta swimming competition in Indonesia. …


Emergency Care Outside Of The Four Walls Of The Emergency Department, Judd E. Hollander Apr 2026

Emergency Care Outside Of The Four Walls Of The Emergency Department, Judd E. Hollander

Department of Emergency Medicine Faculty Papers

No abstract available


Does What Happens In Vegas Increase Pedestrian Safety? A Longitudinal Study On The Effectiveness Of Pedestrian Bridges, Jalen Paulos, Joaquin Miguel Del Mundo, Brock Wentz, Janel Pietryga Apr 2026

Does What Happens In Vegas Increase Pedestrian Safety? A Longitudinal Study On The Effectiveness Of Pedestrian Bridges, Jalen Paulos, Joaquin Miguel Del Mundo, Brock Wentz, Janel Pietryga

Department of Orthopaedics Faculty Research

Urban populations continue to rise and the frequency that pedestrians are exposed to vehicular traffic continues to increase. The result is an increase in automobile versus pedestrian collisions. This study aims to determine the efficacy of pedestrian bridges in reducing the rates of automobile‒pedestrian collisions. Data for all automobile versus pedestrian collisions and injuries from July 1997 through December 2023 at four distinct intersections along Las Vegas Boulevard were retrieved from the Nevada Department of Transportation. These sites were chosen because of their historically high rates of automobile versus pedestrian incidents and the construction of pedestrian bridges at three of …


Lgr5: From Stem Cell Marker To Therapeutic Target, Peyton C High, Maya G Cappellino, Tiffani A Blackburn, Kendra S Carmon Apr 2026

Lgr5: From Stem Cell Marker To Therapeutic Target, Peyton C High, Maya G Cappellino, Tiffani A Blackburn, Kendra S Carmon

Faculty, Staff and Student Publications

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is an established marker of normal and cancer stemlike cells. LGR5 has been implicated in promoting cancer cell plasticity that drives tumorigenesis, metastasis, and therapeutic resistance. LGR5 rapidly and constitutively internalizes and potentiates Wnt (Wingless/Int-1)/β-catenin and adhesion signaling pathways, though its precise mechanisms and interacting partners remain unresolved. An improved understanding of LGR5 signaling may provide invaluable insight into its intricate and important functions in cancer progression. Moreover, several LGR5-targeting therapies, including peptibody- and antibody-drug conjugates and bispecific antibodies, are showing promising efficacy and tolerability in colorectal cancer and other tumor types. This …


A Qualitative Analysis Of Pediatricians' Perspectives Regarding Barriers, Facilitators, And Strategies For Providing Timely Autism Spectrum Disorder Screening And Diagnosis, Mallika Mathur, Jinni Tang, Christine Markham, Sandra Mckay, Ruosha Li, Deepali Ernest, Allison Marshall, Shreela Sharma Apr 2026

A Qualitative Analysis Of Pediatricians' Perspectives Regarding Barriers, Facilitators, And Strategies For Providing Timely Autism Spectrum Disorder Screening And Diagnosis, Mallika Mathur, Jinni Tang, Christine Markham, Sandra Mckay, Ruosha Li, Deepali Ernest, Allison Marshall, Shreela Sharma

Faculty, Staff and Student Publications

Background: Autism spectrum disorder (ASD) is a developmental disorder that has increased in prevalence over the years. Diagnosis and subsequent intervention by the age of 3 is essential for development. However, recent estimates indicate that less than 50% of children receive an evaluation by age 3. Underserved populations are more likely to receive an evaluation at an older age. Several barriers in the diagnostic process have been identified; however, limited studies have aimed at understanding the specifics of these barriers among underserved populations and whether current strategies are beneficial for all children.

Objectives: The aim of this study was to …


Mitochondrial Presequences Harbor Variable Strengths To Maintain Organellar Function, Youmian Yan, Baigalmaa Erdenepurev, Thiago N Menezes, Ian Collinson, Natalie M Niemi Apr 2026

Mitochondrial Presequences Harbor Variable Strengths To Maintain Organellar Function, Youmian Yan, Baigalmaa Erdenepurev, Thiago N Menezes, Ian Collinson, Natalie M Niemi

2020-Current year OA Pubs

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of what dictates strong versus weak presequences is lacking. Furthermore, the extent to which presequence strength affects mitochondrial function and cellular fitness remains unclear. Here, we capitalize on the MitoLuc protein import assay to define multiple aspects of presequence strength. We find that select presequences, including …