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Full-Text Articles in Medicine and Health Sciences

Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs Jan 2024

Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Perinatal substance use (PSU) is a serious and growing public health concern. It is associated with a variety of adverse health outcomes for both mother and child and has been shown to negatively impact the parent-child relationship. Despite the growing prevalence of PSU, there are notable deficits in provider knowledge regarding, and comfortability with, PSU. Moreover, providers report feelings of judgment, resentment, fear, and hesitancy related to their work with women with PSU. Subsequently, women with PSU struggle to find appropriate, compassionate, and effective treatment for their substance misuse. Widespread and accessible training is needed to bolster provider knowledge base, …


A Flavonoid-Rich Diet Is Associated With Lower Risk And Improved Imaging Biomarkers Of Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study, William Bell, Amy Jennings, Alysha S. Thompson, Nicola P. Bondonno, Anna Tresserra-Rimbau, Tilman Kühn, Aedín Cassidy Jan 2024

A Flavonoid-Rich Diet Is Associated With Lower Risk And Improved Imaging Biomarkers Of Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study, William Bell, Amy Jennings, Alysha S. Thompson, Nicola P. Bondonno, Anna Tresserra-Rimbau, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Background: Mechanistic studies and short-term randomized trials suggest higher intakes of dietary flavonoids may protect against nonalcoholic fatty liver disease (NAFLD).

Objectives: We aimed to perform the first population-based study with long-term follow-up on flavonoid consumption, incident NAFLD, and validated NAFLD biomarkers.

Methods: In a prospective study, we assessed the associations between flavonoid intake based on ≥2 24-h dietary assessments and NAFLD risk among 121,064 adults aged 40–69 y by multivariable Cox regression analyses. We further assessed the associations between flavonoid intake and magnetic resonance imaging-derived liver fat (a subset of n = 11,435) and liver-corrected T1 values (cT1; a …


The Caregiving Role Influences Suboptimal Health Status And Psychological Symptoms In Unpaid Carers, Monique Garcia, Zheng Guo, Yulu Zheng, Zhiyuan Wu, Ethan Visser, Lois Balmer, Wei Wang Jan 2024

The Caregiving Role Influences Suboptimal Health Status And Psychological Symptoms In Unpaid Carers, Monique Garcia, Zheng Guo, Yulu Zheng, Zhiyuan Wu, Ethan Visser, Lois Balmer, Wei Wang

Research outputs 2022 to 2026

Background: Suboptimal Health Status (SHS) is the physical state between health and disease. This study aimed to fill in the knowledge gap by investigating the prevalence of SHS and psychological symptoms among unpaid carers and to identify SHS-risk factors from the perspective of predictive, preventive and personalised medicine (PPPM). Methods: A cross-sectional study was conducted among 368 participants who were enrolled from Australia, including 203 unpaid carers as cases and 165 individuals from the general population as controls. SHS scores were measured using SHSQ-25 (Suboptimal Health Status Questionnaire-25), whilst psychological symptoms were measured by DASS-21 (Depression, Anxiety and Stress Scale-21). …


The Anatomy Of Physician Fulfillment: Strategies Beyond Burnout, Brook Hale Jan 2024

The Anatomy Of Physician Fulfillment: Strategies Beyond Burnout, Brook Hale

Antioch University Dissertations & Theses

The persistent tension and power struggle between healthcare executives and physicians is a prevalent issue in healthcare organizations, often leading to a culture of organizational mistrust. This dynamic stems from perceived conflicting goals: executives are frequently seen as primarily focused on financial outcomes, while physicians are viewed as resistant to change. This study explored how physician fulfillment is experienced at work, with the ultimate goal of identifying potential interventions to bridge the gap between these groups. There is vast research and literature available regarding burnout in healthcare; this research focused on understanding what physicians find fulfilling in their work and …


Summary Of Epidemiology, Prevention And Management Of Blood-Borne Viruses Experienced By Aboriginal And Torres Strait Islander Peoples, Australian Indigenous Healthinfonet Jan 2024

Summary Of Epidemiology, Prevention And Management Of Blood-Borne Viruses Experienced By Aboriginal And Torres Strait Islander Peoples, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

This Summary is based on the Review of epidemiology, prevention and management of blood-borne viruses experienced by Aboriginal and Torres Strait Islander peoples (2024).

It aims to provide a synthesis of key information on blood-borne viruses (BBVs) experienced by Aboriginal and Torres Strait Islander peoples in Australia, focusing primarily on hepatitis B virus, hepatitis C virus, and human immunodeficiency virus.

It covers: the historical, social and cultural context of Aboriginal and Torres Strait Islander peoples and BBVs the extent of BBVs, including incidence, prevalence, health service utilisation, hospitalisation, mortality, and burden of disease prevention and management of BBVs relevant programs, …


Pilbara Food Community: Snapshot Report, Isabelle Chiera, Jess Doe, Amanda Devine, Melissa Stoneham, Stephanie L. Godrich Jan 2024

Pilbara Food Community: Snapshot Report, Isabelle Chiera, Jess Doe, Amanda Devine, Melissa Stoneham, Stephanie L. Godrich

Research outputs 2022 to 2026

Food security refers to the adequate physical, social, and economic access to healthy food at all times. The Pilbara Food Community project aimed to identify, map, evaluate and strengthen food security initiatives across the region, to support food security action. This report outlines the findings from the Pilbara Food Community project, detailing the different types of food security initiatives operating within the region. It provides a summary of how Pilbara initiatives are contributing to food security systems change, and how they are working in partnership to deliver their food security initiatives. Based on these findings, region-based recommendations are provided to …


The Lived Experience Of The Covid-19 Pandemic Among Mandate-Resistant Adults In Washington State, Amber N. Peterson Jan 2024

The Lived Experience Of The Covid-19 Pandemic Among Mandate-Resistant Adults In Washington State, Amber N. Peterson

Antioch University Dissertations & Theses

This study examined the lived experience of self-identified, mandate-resistant adults in Washington state. This study explored participants’ experience of the COVID-19 pandemic, from a retrospective framework by uncovering challenges, silver linings, decision-making, and self-reported mental health. Remote interviews were conducted with nine participants. Participants were between 23–31 years old, mostly male, and over half identified as Black. Through semi structured interviews, data was collected and analyzed using Interpretive Phenomenological Analysis (IPA). Participants described their experiences during the COVID-19 pandemic and highlighted significant changes in the way they lived their lives. Most notably, participants described ways in which they defied COVID-19 …


"Why Does This Have To Be So Hard?": Perinatal Experiences From An Ecological Systems Approach, Caitlin Senk Jan 2024

"Why Does This Have To Be So Hard?": Perinatal Experiences From An Ecological Systems Approach, Caitlin Senk

Antioch University Dissertations & Theses

This study examines the lived experience of the perinatal population to understand how they can be supported from the lens of different ecological systems and what counselors can do to better serve people with uteruses during their perinatal experience. Furthermore, this study aims to utilize an inclusive framework for capturing the perinatal experience of people with uteruses and to explore barriers and facilitators to care through an ecological systems framework. Fifteen participants who have experienced infertility, conception, pregnancy, miscarriage, childbirth, stillbirth, and postpartum were recruited through various means throughout the United States. Thematic analysis was used, with semi-structured interviews and …


Exploring Cultural Humility Prevalence And Barriers In Masters Of Science In Athletic Training Education Programs, Nathalie Towchik Jan 2024

Exploring Cultural Humility Prevalence And Barriers In Masters Of Science In Athletic Training Education Programs, Nathalie Towchik

Antioch University Dissertations & Theses

The purpose of this study is to understand the prevalence of faculty members’ abilities to incorporate cultural humility into their Masters of Science in Athletic Training (MSAT) program curriculum and barriers they feel they face in implementing this into regular practice. There is a severe lack of focus on issues pertaining to social justice within the athletic training profession, and implementation of cultural humility skills into MSAT programs can help address the systemic injustices within athletic training healthcare delivery. While there has been a focus on cultural competency in athletic training education, there is little to no current research on …


My World's On Fire, How 'Bout Yours? An Investigation Of How Privilege Fosters And Maintains Climate Denial, Morgan A. Chester Jan 2024

My World's On Fire, How 'Bout Yours? An Investigation Of How Privilege Fosters And Maintains Climate Denial, Morgan A. Chester

Antioch University Dissertations & Theses

The present study investigates the phenomenon of climate denial through a new theoretical framework of privilege. The analysis utilizes a feminist orientation that builds on a historical interpretation through the lens of colonialism. Through the dissection of current multidisciplinary understandings of climate denial and new concepts discovered in the review of academic literature and popular media, a compilation of theory, relationship, and connection is made. Systems of power and privilege are examined and connected to the mechanisms and maintenance of climate denial. The resulting analysis illuminates that settler colonialism, supported by connected ideologies of White supremacy, ableism, and patriarchy inform …


Understanding The Experience Of Mothers In Higher Education During The Covid-19 Era, Shannan L. Engel Jan 2024

Understanding The Experience Of Mothers In Higher Education During The Covid-19 Era, Shannan L. Engel

Antioch University Dissertations & Theses

This exploratory study aimed to understand the experience of mothers in higher education both during the COVID-19 pandemic and toward the end of restrictions. The population included academic mothers with children at home during the pandemic. Data was analyzed thematically by a team of researchers. The results generated six themes: (a) life changed suddenly, (b) remote work, school, and life, (c) unsupported, (d) sense of control, (e) support, and (f) positive aspects of COVID. These findings are important to the field of mental health counseling profession, supervision, and higher education because of the circumstances exemplified by the pandemic that highlight …


Emotions, Self-Efficacy, And Accountability For Antiracism In White Women Counselors, Lisa Wenninger Jan 2024

Emotions, Self-Efficacy, And Accountability For Antiracism In White Women Counselors, Lisa Wenninger

Antioch University Dissertations & Theses

Supporting the development of an antiracist identity in counselors could facilitate change toward equity, justice, and opportunity within the counseling profession and increase awareness of white counselors in working with clients of color. Understanding obstacles to and enablers of antiracist attitudes in white women counselors holds the potential to bring change to the profession as a whole, given their position in the majority. This quantitative study used instruments to assess white racial affects of white fear, anger, and guilt along with antiracist self-efficacy as influencing antiracist accountability in a sample of white women counselors in the United States (N = …


Lead Poisoning In Children: A Preventable Disease, Heather Aaron Jan 2024

Lead Poisoning In Children: A Preventable Disease, Heather Aaron

Antioch University Dissertations & Theses

Children lead poisoning disease causes irreversible neurological damage in children (Centers for Disease Control and Prevention [CDC], 2022). The effects are lifelong for the children poisoned and their families. A major cause of childhood lead poisoning is the ingestion of peeling paint in old homes. Leaded paint was banned by the federal government in 1978 (Mayo Clinic, 2022). Leaded paint is mostly found in dwellings constructed before 1978. The purpose of this study is to identify barriers, social justice parameters, and solutions to and for the eradication of childhood lead poisoning in Connecticut. The methodology used was a qualitative interview …


Aging In Place With A Warming Climate: Housing Design And Policies For Aging With Extreme Heat, Nichole M. Kain Jan 2024

Aging In Place With A Warming Climate: Housing Design And Policies For Aging With Extreme Heat, Nichole M. Kain

Antioch University Dissertations & Theses

Aging populations—particularly in areas prone to extreme heat—are facing unique residential challenges. In the past 10 years, extreme heat has killed more people in the United States (U.S.) than all other weather hazards combined, and it is expected to get hotter, with extreme heat events predicted to happen more often in the future. People over the age of 65 are disproportionately represented as the majority of heat victims, and are likely to perish in their own homes during these events. Every day, 10,000 people turn age 65 in the U.S. and many are choosing to age and retire in places …


Experiences Of Counselors Working With Adolescents, Allison Bradford Chow Jan 2024

Experiences Of Counselors Working With Adolescents, Allison Bradford Chow

Antioch University Dissertations & Theses

This qualitative study aimed to examine the lived experience of clinical mental health counselors working with adolescents. Participants included pre-licensed (associate) or licensed counselors who predominately work with and have a strong preference for working with adolescent clients. Data was collected through individual interviews and analyzed with a descriptive-interpretative approach. Ten domains were identified as part of data analysis: (a) Understanding Adolescent Culture and Building a Therapeutic Alliance, (b) The Intersection of Counselor and Adolescent Emotions, (c) Transference and Countertransference, (d) Clinical Challenges and Barriers, (e) The Multifaceted Role of Parents, (f) Nuances of Confidentiality, (g) Adolescent Development and Strengths, …


Emdr Gaming Recovery And Insight Protocol (E-Grip): An Approach For Treating Video Game Addiction, Manjit Bath Jan 2024

Emdr Gaming Recovery And Insight Protocol (E-Grip): An Approach For Treating Video Game Addiction, Manjit Bath

Antioch University Dissertations & Theses

The prevalence of video game addiction has escalated with the advancement of digital technologies, posing significant psychological and social challenges. This dissertation introduces the eye movement desensitization and reprocessing (EMDR) Gaming Recovery and Insight Protocol (E-GRIP), a novel therapeutic approach designed to address the complexities of video game addiction. Grounded in the principles of EMDR therapy and incorporating insights into video game culture, E-GRIP aims to treat individuals struggling with problematic gaming behaviors by integrating their gaming experiences and preferences into the therapeutic process. The E-GRIP methodology extends the conventional EMDR framework by including an in-depth exploration of the client’s …


Black And African American Young Adult Male Experiences: Implications For Building Resilience And Survival Skills Within Educational Settings And Public Spaces, Akimma Wright-D'Abreau Jan 2024

Black And African American Young Adult Male Experiences: Implications For Building Resilience And Survival Skills Within Educational Settings And Public Spaces, Akimma Wright-D'Abreau

Antioch University Dissertations & Theses

The aim of this study is to better understand, from the perspective of Critical Race Theory, the experiences of adolescent males who are Black and living in the United States and to examine how they build resilience and survival skills. Participants were between the ages of 18 and 26 and asked to recall adolescent experiences as part of a semi-structured interview with a Black Storytelling approach. There were six participants and data were analyzed using thematic analysis. According to the results, there were seven themes: (1) Policing In the United States of America Comes in Many Forms, (2) Recognizing Racism …


From East To West: Exploring The Mental Health Of Punjabi Immigrants Residing In British Columbia, Jasleen Kaur Jan 2024

From East To West: Exploring The Mental Health Of Punjabi Immigrants Residing In British Columbia, Jasleen Kaur

Antioch University Dissertations & Theses

Mental health has been a topic that is slowly gaining more acknowledgement and awareness over time. However, despite the elevation in awareness, there are many cultures where mental health issues remain subject to stigma, which discourages an individual from seeking, or even acknowledging, mental health treatment and services. This study focuses upon varying perceptions of mental health by exploring in-depth the perception of mental health within the Punjabi community and how Punjabi culture affects such perceptions. Specifically, this research study examines how young adults who immigrated from Punjab, India to British Columbia (B.C.) perceive and respond to mental health concerns. …


Therapeutic Interventions For Adolescents With Non-Epileptic Seizures, Noah Trantel Jan 2024

Therapeutic Interventions For Adolescents With Non-Epileptic Seizures, Noah Trantel

Antioch University Dissertations & Theses

Although there have been some studies that explore the lived experiences of adults with non-epileptic seizures, there have been limited studies that examine the lived experiences of adolescents and emerging adults with non-epileptic seizures. This qualitative study explored the experiences of emerging adults who had been diagnosed with non-epileptic seizures during adolescence. The study focused on specific interventions utilized in therapy that they found helpful, highlighted what their experiences were throughout their daily lives, and what treatment recommendations were provided. The research will also help guide parents, clinicians, and individuals with NES towards treatment recommendations. Eight participants completed an in-depth, …


Evaluating Native American Serving Nontribal Institutions (Nasnti) Admissions Criteria To Create An Inclusive Nursing Workforce, Tori Stanek Jan 2024

Evaluating Native American Serving Nontribal Institutions (Nasnti) Admissions Criteria To Create An Inclusive Nursing Workforce, Tori Stanek

Antioch University Dissertations & Theses

The national nursing shortage is projected to increase as the bulk of the United States population ages out of the workforce and is likely to require more age-related healthcare services. The lack of ethnic, racial, and gender-based diversity in the current workforce exacerbates this shortage, and the need for a diversified workforce acknowledged by governing nursing bodies from as early as 2011 is still largely unmet. This study looks to nursing programs—specifically their application processes—as one factor that contributes to workforce disparities. Guided by several tenets of Tribalcrit Theory (Brayboy, 2005) and the Triarchic Theory of Intelligence (Sternberg, 1985), this …


Like, Comment, Subscribe, And Share: An Investigation Of Emerging Adults’ Lived Experiences Of Relationship Information On Social Media, Marquitta Fields Jan 2024

Like, Comment, Subscribe, And Share: An Investigation Of Emerging Adults’ Lived Experiences Of Relationship Information On Social Media, Marquitta Fields

Antioch University Dissertations & Theses

This qualitative study explores how emerging adults engage with relationship education content on social media platforms and the implications for promoting accessible myself in the personal lived experiences of participants while removing listener preconceptions, identifying psychological structures that explain their interactions with relationship content. The findings reveal that emerging adults use a variety of social media platforms, including Instagram, TikTok, Reddit, Facebook, Pinterest, and YouTube, to consume relationship information. Participants prioritize content that is authentic, relatable, and derived from personal experiences over generic or impersonal advice. They value content that encourages healthy communication, self-reflection, and personal growth. The study also …


Needs Assessment For Sexual Violence Trauma-Informed Care In The Dental Field, Joshua Garufi Jan 2024

Needs Assessment For Sexual Violence Trauma-Informed Care In The Dental Field, Joshua Garufi

Antioch University Dissertations & Theses

Trauma-informed care provides a framework for health care providers to more effectively treat their patients who have a history of trauma (Hamberger et al., 2019). Upon reviewing the literature, there is a paucity of research on trauma-informed care in the dental field. This research performed a needs assessment to determine if trauma-informed care is being implemented into the curriculum at a specific dental school, SUNY Buffalo. This research also inquired about residential dentist and faculty attitudes toward trauma-informed care being implemented in the dental field. Two short, original surveys were administered to residential dentists who recently graduated from the University …


"The In-Betweeners": The Lived Experience Of Adult Cochlear Implant Users, Aylah Sroloff Jan 2024

"The In-Betweeners": The Lived Experience Of Adult Cochlear Implant Users, Aylah Sroloff

Antioch University Dissertations & Theses

This phenomenological study explored the lived experiences of adult cochlear implant (CI) users, implanted prior to the age of 10-years-old. Seven adult CI users were recruited. In-depth, semi-structured, qualitative interviews were conducted to explore participants’ experiences and identities as CI users. Transcripts were analyzed using interpretative phenomenological analysis, through which six group experimental themes were generated: (a) CIs and identity,” (b) social isolation, (c) advocacy, (d), costs and benefits of integration into the hearing world, and (e) “the future of CIs.” This study’s findings highlighted participants’ perspectives on living with CIs, the challenges they face, their process of identity exploration, …


Clinical-Grade Human Skin-Derived Abcb5+ Mesenchymal Stromal Cells Exert Anti-Apoptotic And Anti-Inflammatory Effects In Vitro And Modulate Mrna Expression In A Cisplatin-Induced Kidney Injury Murine Model, Erika Rendra, Adriana T. Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback Jan 2024

Clinical-Grade Human Skin-Derived Abcb5+ Mesenchymal Stromal Cells Exert Anti-Apoptotic And Anti-Inflammatory Effects In Vitro And Modulate Mrna Expression In A Cisplatin-Induced Kidney Injury Murine Model, Erika Rendra, Adriana T. Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback

Research outputs 2022 to 2026

Acute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer chemotherapeutic agent cisplatin often induces AKI as an adverse drug side effect. Therapies targeted at the reversal of AKI and its potential progression to chronic kidney disease or end-stage renal disease are currently insufficiently effective. Mesenchymal stromal cells (MSCs) possess diverse immunomodulatory properties that confer upon them significant therapeutic potential for the treatment of diverse inflammatory disorders. Human dermal MSCs expressing ATP-Binding Cassette member B5 (ABCB5) have shown therapeutic efficacy in clinical trials in chronic skin wounds or …


Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead Jan 2024

Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead

Research outputs 2022 to 2026

Background: Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. Methods: PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched. Two independent reviewers screened, extracted, and quality-appraised the studies using JBI SUMARI software. Forest plots were created with the standardized mean difference using the random-effects model, and heterogeneity was assessed using I2. …


Nurse Knowledge, Attitudes, And Barriers To Pressure Injuries: A Cross-Sectional Study In An Australian Metropolitan Teaching Hospital, Linda Coventry, Amanda Towell-Barnard, Joelle Winderbaum, Nicole Walsh, Mark Jenkins, Dimitri Beeckman Jan 2024

Nurse Knowledge, Attitudes, And Barriers To Pressure Injuries: A Cross-Sectional Study In An Australian Metropolitan Teaching Hospital, Linda Coventry, Amanda Towell-Barnard, Joelle Winderbaum, Nicole Walsh, Mark Jenkins, Dimitri Beeckman

Research outputs 2022 to 2026

Background: Pressure injuries are associated with significant clinical complications with negative effects on the patient's emotional, psychological, social and physical wellbeing. However, in Australia little is known about the knowledge and attitudes of nurses towards hospital-acquired pressure injuries.

Objective: To determine nurse knowledge and attitudes towards hospital-acquired pressure injuries and to identify barriers towards prevention.

Methods: A cross-sectional study following the STROBE statement was conducted between May to July in 2017. All nurses at a major metropolitan teaching hospital in Western Australia were invited to participate. Nurse knowledge and attitude to pressure injury were assessed using validated Pressure Ulcer Knowledge …


Visit North Carolina: Trail Accessibility, Hannah Caitlyn Guschel Jan 2024

Visit North Carolina: Trail Accessibility, Hannah Caitlyn Guschel

Graduate Theses, Dissertations, and Problem Reports (ETD)

This paper focuses on the perceived barriers to travel from marketing material for individuals with disabilities compared to those without disabilities and the direct impact on leisurely travel participation, particularly in outdoor spaces. Employing a cross-sectional study design encompassing both quantitative and qualitative data collection methods, this research investigates the experiences and transparency of trail accessibility in the state of North Carolina. Quantitative data were gathered through trail assessment accessibility checklists, while qualitative insights were obtained via in-depth interviews. The findings reveal an improved understanding of accessibility and the application of an accessibility checklist. Moreover, the study underscores the importance …


Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey Jan 2024

Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Systemic chemotherapy is a cornerstone of cancer treatment, but it often leads to significant side effects, which may impact patients' quality of life and lead to increased acute healthcare utilization. Although patients are typically informed of potential symptoms and advised to seek care as needed, many struggle to understand and manage symptoms effectively. Patient-reported outcomes (PROs) have been shown to improve symptom monitoring, decrease symptom burden, and reduce emergency department visits and hospital admissions. Electronic patient-reported outcomes (ePROs), in particular, offer timely and accessible symptom tracking, though their effectiveness has largely been evaluated within urban clinical trial settings and …


Breast Tissue As A Local Drug Reservoir For Anticancer Therapy In Breast Cancer, Saniia Shchinar Jan 2024

Breast Tissue As A Local Drug Reservoir For Anticancer Therapy In Breast Cancer, Saniia Shchinar

Electronic Theses and Dissertations

Breast cancer, particularly the estrogen receptor-positive (ER+) subtype, remains a formidable challenge in oncology. Traditional oral therapies for ER-positive breast cancer, such as selective estrogen receptor modulators (SERMs) like Tamoxifen (TAM) and Toremifene (TOR), often encounter issues related to limited bioavailability, metabolic complications, and significant systemic side effects. These side effects include the risk of blood clots, hot flashes, vaginal dryness, menstrual cycle disruptions, and uterus cancer, which can hinder long-term adherence to preventive therapy. The exploration of local drug delivery into breast tissue presents a promising alternative to tackle these challenges. In this study, we explored the feasibility of …


Delivery Of Gemcitabine, Stearoyl Gemcitabine And Paclitaxel Through Plga Nanoparticles And Its Effect On The Desmoplasia Of Pancreatic Cancer Spheroids, Rishabh Bahl Jan 2024

Delivery Of Gemcitabine, Stearoyl Gemcitabine And Paclitaxel Through Plga Nanoparticles And Its Effect On The Desmoplasia Of Pancreatic Cancer Spheroids, Rishabh Bahl

Electronic Theses and Dissertations

Pancreatic cancer is one of the deadliest cancers to treat. The primary cause for the drug resistance is the dense extracellular matrix (ECM) that surrounds the tumor and restricts blood supply. Gemcitabine (GEM) and paclitaxel (PTX) are drugs that are clinically used in the treatment of pancreatic cancer. GEM, however, is rapidly metabolized by cytidine deaminase (CDA) and eliminated from the body, and paclitaxel is a substrate for P- glycoprotein (P-gp) efflux receptors. Drug delivery using nanoparticles has been reported to help improve drug half-lives and bypass efflux receptors. This thesis aims to encapsulate PTX in PLGA nanoparticles (PTX-NP) and …