Isolation, Molecular Characterization, And Epidemiological Analysis Of An Emerging Avian Metapneumovirus Subgroup B In Us Poultry, Sumit Jangra

Electronic Theses and Dissertations

Avian metapneumovirus (aMPV) is one the most economically important poultry respiratory pathogens belonging to the family Pneumoviridae and genus Metapneumovirus, which can affect both domestic and wild birds. aMPVs are classified into four subgroups (A, B, C, and D) based on the level of genetic variations and antigenic differences. aMPV causes turkey rhinotracheitis (TRT) and swollen head syndrome (SHS) in turkeys and chickens respectively. Recently, outbreaks of respiratory disease in meat-type birds and a significant decline in egg production with respiratory signs in breeders were reported from different states in the USA. Isolating aMPV is challenging as it is a …

Dietary Knowledge And Eating Habits Among Patients With Type 2 Diabetes In Lebanon, Myriam Abboud, Cyrille Nacouzi, Zeina Chahine, Angelica Atallah, Mira Hleyhel

All Works

Little is known about the dietary knowledge (DK) and eating habits (EHs) of patients with type 2 diabetes (T2D) in Lebanon. Therefore, the aim of this study was to assess the DK and EH of the population with T2D and determine their associated factors. A cross-sectional survey enrolling 351 patients with T2D was carried out, using the snowball sampling technique. The survey used the UK Diabetes and Diet Questionnaire and the Dietary Knowledge questionnaire to assess participants' EH including the frequency of consumption of certain foods and their knowledge of food groups and food choices. While a higher DK index …

Prevalence Of Premenstrual Syndrome And Its Associations With Dietary And Other Lifestyle Factors Among University Female Students In Dubai: A Cross-Sectional Study, Haleama Al Sabbah, Noof Al Mutawa, Enas A. Assaf

All Works

Background: Premenstrual syndrome is a relatively prevalent condition that affects a significant number of menstruating women worldwide. It can range from mild to severe and may interfere with daily activities. Objective: This study aims to investigate the prevalence of premenstrual syndrome and its associated factors among female university students in Dubai. Design: This study was designed as a cross-sectional study. Methods: The analysis for this study involved 217 female university students (aged ⩾18 years old) who completed a self-reported online questionnaire. Participants were recruited through simple random sampling, and the study received ethical approval from the Zayed University Ethical Committee. …

A Digital Heliometric Device For Monitoring Sun Exposure In Cases Of Hypovitaminosis D: A Qualitative Analysis Of User Evaluations From The Uae, Reem Salem, Justin Thomas, Asad Khattak, Fatme Al Anouti

All Works

Background: Hypovitaminosis D is a significant health concern in the United Arab Emirates (UAE), particularly among females. Wearable devices designed to encourage safe sun exposure could potentially help individuals achieve and sustain healthy vitamin D levels. Objective: This qualitative, proof-of-concept study aimed to explore the evaluations of Emirati women with hypovitaminosis D regarding the usability and effectiveness of wearing a novel heliometric device to promote and measure safe sun exposure. Methods: Nine Emirati women, aged between 19 and 21, adhered to a protocol stipulating that they wear the heliometric device (a wristband) for 10 min daily over one week. Participants …

Helping Students Make Meaningful Connections: A Cross-Sectional Survey Of College Student Loneliness, Alicia Wodika, Jacqueline Lanier, Jim Almeda, Aubrey Richter, Gabriella Schalasky

Faculty Publications – Health Sciences

Background

Young adults are experiencing high levels of anxiety, depression, and loneliness. At colleges and universities across the United States, programs exist to address student mental health needs exacerbated by the COVID-19 pandemic.

Purpose

Current levels of loneliness among students (n = 487) at a Midwest university were researched to compare with previous trends and develop clearer recommendations for purposeful interventions.

Methods

This study utilized a cross-sectional study design with the UCLA Loneliness Scale during the fall 2022 semester.

Results

Higher levels of loneliness were linked to the demographics of identifying as cis-males, non-binary, and/or students of color. Students …

Predicting Radiation-Induced Immune Suppression In Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy, Jonathan Colen, Cam Nguyen, Seth W. Liyanage, Eric Aliotta, Joe Chen, Clayton Alonso, Kara Romano, Sean Peach, Timothy Showalter, Paul Read, James Larner, Krishni Wijesooriya

Data Science Faculty Publications

BACKGROUND: Stereotactic body radiation therapy (SBRT) is known to modulate the immune system and contribute to the generation of anti-tumor T cells and stimulate T cell infiltration into tumors. Radiation-induced immune suppression (RIIS) is a side effect of radiation therapy that can decrease immunological function by killing naive T cells as well as SBRT-induced newly created effector T cells, suppressing the immune response to tumors and increasing susceptibility to infections.

PURPOSE: RIIS varies substantially among patients and it is currently unclear what drives this variability. Models that can accurately predict RIIS in near real time based on treatment plan characteristics …

Triphlapan: Predicting Hla Molecules Binding Peptides Based On Triple Coding Matrix And Transfer Learning, Meng Wang, Chuqi Lei, Jianxin Wang, Yaohang Li, Min Li

Computer Science Faculty Publications

Human leukocyte antigen (HLA) recognizes foreign threats and triggers immune responses by presenting peptides to T cells. Computationally modeling the binding patterns between peptide and HLA is very important for the development of tumor vaccines. However, it is still a big challenge to accurately predict HLA molecules binding peptides. In this paper, we develop a new model TripHLApan for predicting HLA molecules binding peptides by integrating triple coding matrix, BiGRU + Attention models, and transfer learning strategy. We have found the main interaction site regions between HLA molecules and peptides, as well as the correlation between HLA encoding and binding …

Implementation Of A Targeted “Micro-Learning” Inpatient Diabetes Education Program In A Rural Hospital Setting, Melissa Lynn Fannon-Wisner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction/Background: Diabetes affects a large portion of Americans and West Virginians annually. Inpatient hospitalization provides an opportunity to provide evidence-based diabetes education to patients. A lack of access to diabetes education at rural hospitals across the United States exists, creating a need for patients who require education while hospitalized. An intervention needs to be explored to bridge the gap for patients that need education when the diabetes educator is not available.

Purpose: The purpose of this Doctor of Nursing Practice (DNP) project is to create and implement a video micro-learning diabetic education series that can be utilized for diabetes self-management …

Life After Sport: A Program Development Plan For Student-Athletes, Loryn Shawn Frame

Graduate Theses, Dissertations, and Problem Reports (ETD)

College athletics stakeholders have had growing concerns regarding student-athletes’ transition out of collegiate athletics. Research specific to student-athletes following college athletics has explored mental health, role identity, and occupational participation. This program development plan addresses occupational therapy’s role in assisting student-athletes transition out of collegiate athletics. The needs assessment conducted with West Virginia University athletic staff revealed two gaps in programming: athletic identity including leisure exploration, and a program to help student-athletes who want to enter health professional programs. Life After Sport comprises two programs, one to help student-athletes transition into a health professional program, titled Athletes in Medicine (AIM), …

Treatment Patterns And Clinical And Economic Burden In Patients With Merkel Cell Carcinoma: Statistical And Machine Learning Approaches, Yves Mbous

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although considered a rare form of nonmelanoma skin cancer, Merkel Cell Carcinoma incidence rate has increased to 0.74 per 100,000 and projections expect this number to steadily rise over the next decades and to reach an average of 3,285 cases per year in 2025. MCC incidence increases significantly with age. Among those aged 40-44, it is 0.44, it rises to 1.0/100,000 in the 60-64 age group and soars to 9.8/100,000 among those ≥85 years and above. Due to the small number of cases, MCC is often managed using institutional practices or provider preferences. Formal clinical trials that enroll early stage …

E-Cigarette Aerosol’S Effect On The Force Degradation Of Elastomeric Chain: An In Vitro Study, Joshua D. Lokant

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

E-Cigarette Aerosol’s Effect on the Force Degradation of Elastomeric Chain: An in Vitro Study

Joshua Lokant D.D.S.

Background and Objectives

Orthodontic elastomeric chain is used in orthodontic treatment for various applications such as closing spaces, aligning teeth, correcting midlines, promoting even spaces, and retracting teeth. Ideally, this force is light, continuous, and maintains a constant force between orthodontic appointments. There are many companies that manufacture polyurethane power chain, and their proprietary formulas give rise to different force levels and constancy of force. When the power chain is in the mouth, it is subject to food, liquids, temperature changes, pH …

‘Heavy’ Life Satisfaction: Unveiling The Intricate Relationships Between Obesity And Well-Being In Abu Dhabi, Masood Badri, Mugheer Alkhaili, Hamad Aldhaheri, Saad Yaqeib, Guang Yang, Muna Albahar, Asma Alrashdi

All Works

The study investigates the intricate relationship between obesity and well-being among residents in Abu Dhabi. Obesity is recognized as a significant public health concern worldwide, with potential implications for individuals' overall well-being. Understanding the complex associations between obesity and various aspects of well-being is essential for developing effective interventions to promote healthier lifestyles and improve overall quality of life. The research employs path analysis to explore the direct associations between obesity and multiple well-being indicators. Data is collected from residents in Abu Dhabi, focusing on subjective health, subjective mental health, life satisfaction, physical exercise, and satisfaction with social relationships. Path …

Advancing Sepsis Clinical Research: Harnessing Transcriptomics For An Omics-Based Strategy - A Comprehensive Scoping Review, Asrar Rashid, Feras Al-Obeidat, Hari Krishnan Kanthimathinathan, Govind Benakatti, Wael Hafez, Raghu Ramaiah, Joe Brierley, Benjamin Hanisch, Praveen Khilnani, Christos Koutentis, Berit S. Brusletto, Mohammed Toufiq, Zain Hussain, Harish Vyas, Zainab A Malik, Maike Schumacher, Rayaz A Malik, Shriprasad Deshpande, Nasir Quraishi, Raziya Kadwa, Amrita Sarpal, M. Guftar Shaikh, Javed Sharief, Syed Ahmed Zaki, Rajesh Phatak, Akash Deep, Ahmed Al-Dubai, Amir Hussain

All Works

Sepsis continues to be recognized as a significant global health challenge across all ages and is characterized by a complex pathophysiology. In this scoping review, PRISMA-ScR guidelines were adhered to, and a transcriptomic methodology was adopted, with the protocol registered on the Open Science Framework. We hypothesized that gene expression analysis could provide a foundation for establishing a clinical research framework for sepsis. A comprehensive search of the PubMed database was conducted with a particular focus on original research and systematic reviews of transcriptomic sepsis studies published between 2012 and 2022. Both coding and non-coding gene expression studies have been …

Cimex (Bedbug) Infestations In France: A Call For Action, Wael Hafez, Waleed Farouk Mohamed, Feras Al-Obeidat, Sarya Swed, Hidar Alibrahim, Haidara Bohsas, Bisher Sawaf, Asrar Rashid, Alfonso J. Rodriguez-Morales

All Works

No abstract provided.

Estimated Glomerular Filtration Rate Slope And Risk Of Primary And Secondary Major Adverse Cardiovascular Events And Heart Failure Hospitalization In People With Type 2 Diabetes: An Analysis Of The Exscel Trial, Abderrahim Oulhaj, Faisal Aziz, Abubaker Suliman, Kathrin Eller, Rachid Bentoumi, John B. Buse, Wael Al Mahmeed, Dirk Von Lewinski, Ruth L. Coleman, Rury R. Holman, Harald Sourij

All Works

Aim: The decline in estimated glomerular filtration rate (eGFR), a significant predictor of cardiovascular disease (CVD), occurs heterogeneously in people with diabetes because of various risk factors. We investigated the role of eGFR decline in predicting CVD events in people with type 2 diabetes in both primary and secondary CVD prevention settings. Materials and Methods: Bayesian joint modelling of repeated measures of eGFR and time to CVD event was applied to the Exenatide Study of Cardiovascular Event Lowering (EXSCEL) trial to examine the association between the eGFR slope and the incidence of major adverse CV event/hospitalization for heart failure (MACE/hHF) …

Association Between Hemoglobin Level, Anemia, And Hypertension Among Adults In Northern Sudan: A Community-Based Cross-Sectional Study, Zainab Taha, Hiba Elhag, Ahmed Ali Hassan, Ishag Adam

All Works

Background: Hypertension and anemia are major health problems globally. However, data regarding the association between hypertension and hemoglobin/anemia among adults are few and controversial. Therefore, the current study aimed to investigate the associations between hemoglobin/anemia and hypertension among Sudanese adults. Methods: A community-based cross-sectional study was conducted in Northern Sudan from September to December 2022. The participants’ sociodemographic characteristics were assessed using a questionnaire. Standardized procedures measured participants’ weight, height, body mass index (BMI), hemoglobin, and hypertension. Multivariate regression analysis was performed to determine the association between anemia and hypertension. Results: Three hundred eighty-four adults were enrolled; 195 (50.8%) and …

The Assessment Of Knowledge Management Dimensions In The Libraries Of Khorasan Razavi Universities, Alireza Atarodi, Soraya Ziaei, Jamileh Naeimi, Hassan Shojaee-Mend

Library Philosophy and Practice (e-journal)

Introduction: This study aims to assess knowledge management aspects in central libraries of Islamic Azad University, Ministry of Science, Research and Technology, and Ministry of Health, Treatment, and Medical Education in Khorasan Razavi Province, Iran.

Methods: Conducted through a survey-analytical approach, this study focused on librarians with library education in central university libraries of Khorasan Razavi Province. A sample size of 102 individuals was selected using Cochran's formula. Validity and reliability of a researcher-developed questionnaire were confirmed. Hypotheses were tested with Wilcoxon and Kruskal-Wallis tests using SPSS-20.

Results: University libraries in Khorasan Razavi Province display inadequacies in …

Voices In End-Of-Life Care: Gathering Perspectives Of Speech-Language Pathologists On End-Of-Life Issues In Medical Settings, Kori Bess Benton

Online Theses and Dissertations

Despite healthcare professionals becoming increasingly aware of the needs of the end-of-life care population, little research exists regarding the roles speech-language pathologists play in providing care for that population. This study investigates perspectives of speech-language pathologists on their roles and preparedness for engaging in end-of-life care. Eight participants engaged in semi-structured interviews to share their experiences in end-of-life care. Interviews were conducted and transcribed, then analyzed to establish common themes amongst speech-language pathologists working in this setting. This study found that speech-language pathologists do not feel they received adequate training related to their role in end-of-life care and share unique …

Been There Done That: A Narrative Analysis Of Disabled Speech-Language Pathology Graduate Students, Elizabeth Maclaren Jones

Online Theses and Dissertations

There is no formal research completed that investigates the lived experiences of disabled speech-language pathology graduate students. This research study utilized a narrative approach. The data were collected through two virtual semi-structured interviews that lasted between 30-40 minutes. The initial coding was done using the qualitative research software ATLAS.ti. The final coding was completed manually. Thematic analysis of relevant In Vivo codes revealed three overarching themes. These themes include self-advocacy, self-disclosure, and self-reliance. In addition to these broader themes, nine minor themes also emerged that helped to develop the three major themes. These minor themes include miscommunication, vulnerability, lack of …

The Effects Of Masks On Speech Perception: A Case Study Of A 5-Year-Old, Megan Jameson

Online Theses and Dissertations

Through a case study design, this research examined whether mask usage in communication partners influenced speech perception in a 5-year-old child, and if so, what that effect was. Participants were recruited using a mix of electronic and physical flyers. Participants had to meet all inclusion criteria, including being English speaking, typical developing, and the age of 5 years for the duration of the study. Typical development was determined through the usage of three screeners; hearing, articulation, and language. Three children were screened, but only one met all inclusion criteria for the study. This individual went on to participate in phase …

Lateralization Of Motor Behavior As A Measure Of Cognitive Functioning And Resting-State Electrocortical Activity, Alina Dillahunt

Master's Theses and Doctoral Dissertations

Background. Research has shown that the laterality between hands in self-report and motor measures maps onto hemispheric lateralization and this has important implications for psychopathology (e.g., depression) and cognition. The present study evaluates the relationship between performance on finger-tapping tasks (FTT), alpha power during resting-state electroencephalography (EEG), handedness, and relevant psychological outcomes. Methods. A sample of 48 individuals between the ages of 18 and 35 completed online assessments including a modified FTT paradigm, the Edinburgh Handedness Inventory, and a common depression measure. A subset of 20 participants completed assessments of motor and executive functioning including a self-report executive functioning measure, …

Behavioral Health Training For Integrated Behavioral Health: A Delphi Study, Nicholas Schmoyer, Lisa Corbin, Jessica Huffman, Gülşah Kemer

PCOM Scholarly Works

Using a classical Delphi design, the authors used an interdisciplinary panel of behavioral health experts in integrated behavioral health (IBH) to identify foundational skills and knowledge counselor educators need to teach clinical mental health counselors for IBH practice. Eighty-eight statements were identified. Implications are provided for counseling and other behavioral health educators.

Tumor Integrin Targeted Theranostic Iron Oxide Nanoparticles For Delivery Of Caffeic Acid Phenethyl Ester: Preparation, Characterization, And Anti-Myeloma Activities., Barkley Smith, Yuancheng Li, Travis Fields, Michael Tucker, Anna Staskiewicz, Erica Wong, Handong Ma, Hui Mao, Xinyu Wang

PCOM Scholarly Works

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress. As part of our continuous effort to pursue a less toxic yet more effective therapeutic approach for MM, the objective of this study …

High Amniotic Fluid Fractalkine And Mip-1Β Levels Are Associated With Intrauterine Growth Restriction: A Prospective Cohort Study, Şehmus Pala, Remzi Atilgan, Nevin İlhan

Turkish Journal of Medical Sciences

Proinflammatory chemokines have been shown to play crucial roles in implantation, spiral artery invasion, and thefetomaternal immunological response. In this context, we investigated the levels of fractalkine (CX3CL1) and chemokine CC motifligand 4 (CCL4 or MIP-1β) in maternal serum and amniotic fluids in pregnant women with intrauterine growth restriction (IUGR).Materials and methods: This prospective cohort study was carried out at Fırat University Obstetrics Clinic between January 1, 2022 andJuly 1, 2022. Group (G) 1: The control group consisted of 40 pregnant women who underwent elective cesarean section (CS) at 38–40weeks of gestation. G2: A total of 40 pregnant women with …

Evaluation Of Single-Layer Versus Double-Layer Suturing Of Low Transverse Uterine Incisions In Cesarean Section And Follow-Up Of Scars By Ultrasound: A Prospective Randomized Controlled Study, Erhan Demi̇rdağ, Hazal Kutlucan, Anil Tutal, Bi̇lge Çalişkan Keski̇nsoy, Gülşah Karakuyu, Recep Karabacak

Turkish Journal of Medical Sciences

Background/aim: Cesarean section(CS) is a widely performed operation worldwide. Data about uterine closure is lacking. We aimed to evaluate scar niches and compare the single and double-layer uterine closure after six months following CS.Materials-Methods: A prospective, randomized trial assessed 56 women undergoing single or double-layer uterine closure. None of the patients had previous uterine surgery. The CSs were elective cases. Transvaginal ultrasound was performed six months after CS to assess uterine scar by measuring the width, depth, and length of scar niche and residual myometrial thickness. An experienced sonographer was blinded to the uterine closure technique and the ultrasounds were …

Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut

Turkish Journal of Medical Sciences

Background/aim: This study aims to compare the Greulich–Pyle (GP) and Tanner–Whitehouse 2 (TW2) methods, both used in left wrist radiography for bone age determination in the pediatric age group, with the Capitohamatum method (CH) due to the importance of determining bone age in the pediatric period.Materials and methods: Direct radiographs of 210 female and 291 male individuals between the ages of 0–15 without any pathology in the left wrist bones were obtained; 501 os capitatum and os hamatum on anterior-to-posterior direct graphic images were measured using the GP, TW2, and CH planimetry methods. The estimated age of each measurement was …

Occupational Therapy Interventions For School-Aged Children To Improve Handwriting Outcomes: A Systematized Review, Cassidy P. Johnson, Carley E. Leners, Ashley N. Stanton, Nicole A. Wiese, Danielle Westmark, Stacy Smallfield, Molly Whitlow

Student Systematized Reviews: Occupational Therapy

Importance: The development of handwriting skills builds a child’s confidence, self-esteem, fine motor skills, ability to communicate effectively and overall academic success (Feder & Majnemer, 2007).

Objective: The purpose of this systematized review was to determine which occupational therapy interventions are most effective for improving handwriting outcomes for prekindergarten through 3rd grade students.

Data sources: Searches were performed by a medical librarian in PubMed, CINAHL and ERIC including articles from 2014 to 2024.

Design: Studies were included if they were English-language articles with a level of evidence of I, II, or III that focused on occupational therapy interventions with an …

Ot Interventions For Post-Stroke Depression: A Systematized Review, Jack Cosgrove, Austin Fernau, Christian Kwambamba, Claire Vanderbeek, Danielle Westmark, Stacy Smallfield, Molly Whitlow

Student Systematized Reviews: Occupational Therapy

Importance: Strokes are a leading cause of disability. 35-50% of stroke survivors develop depression, which is the most common physiological impairment post-stroke and associated with less functional independence with activities of daily living (ADLs) (Ezema et al., 2019; Hildebrand, 2014; Wijeratne & Sales, 2021).

Objective: This systematized review addressed interventions within the scope of occupational therapy that are effective for reducing depressive symptoms for adults post-stroke.

Data sources: A medical librarian searched the databases Medline, PsycINFO, and CINAHL. Quantitative studies, systematic reviews, meta-analyses, and randomized controlled trials published in English within the last ten years were included.

Study selection and …

Breaking The Bamboo Ceiling And De-Bunking The Model Minority Myth, Yun Saksena

Journal Articles: College of Dentistry

Leadership roles must incorporate representation from all involved individuals for the resulting decision-making process to reflect the interests and expertise of a diverse organization. Many resources have rightly focused on developing historically underrepresented racial and ethnic (HURE) leaders. Though numbers of Black and Hispanic dental school deans have increased, more work is needed for these and other HURE groups such as American Indians. Asians are not classified as HURE. As an aggregated group they have robust presence in the dental workforce in North America, the United Kingdom and Australia. The assumption is they are fine, so the group is ignored. …

Management Of Factor Xa Inhibitor-Related Traumatic Non-Intracranial Bleeding Events With Andexanet Alfa Or Four-Factor Prothrombin Complex Concentrate In A Us Multicenter Observational Study, Paul P. Dobesh, Craig I. Coleman, Mark Danese, Eva Lesén, Raymond C. Chang, Onivefu Odelade, Gregory J. Fermann

Journal Articles: Pharmacy Practice

OBJECTIVES: This study describes clinical characteristics and management strategies for patients with factor Xa (FXa) inhibitor-related traumatic non-intracranial bleeds who were treated with andexanet alfa or four-factor prothrombin complex concentrate (4F-PCC).

METHODS: An observational cohort study (ClinicalTrials.gov Identifier: NCT05548777) was conducted using electronic health records from 354 US hospitals. Included patients were hospitalized with rivaroxaban- or apixaban-related bleeding, had received andexanet alfa or 4F-PCC treatment during their hospitalization, and were discharged between May 2018 and September 2022. This analysis was performed in the subgroup of patients with traumatic non-intracranial critical compartment/non-compressible bleeds or other traumatic bleeds.

RESULTS: The study population …