Medicine and Health Sciences Commons^™

Coumarin-Based Aldo-Keto Reductase Family 1c (Akr1c) 2 And 3 Inhibitors, Sravan Jonnalagadda, Ling Duan, Louise F. Dow, Geetha P. Boligala, Elizabeth A. Kosmacek, Kristyn Mccoy, Rebecca E. Oberley-Deegan, Yashpal Singh Chhonker, Darryl J. Murry, C. Patrick Reynolds, Barry J. Maurer, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

A series of 7-substituted coumarin derivatives have been characterized as pan-aldo-keto reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved in drug resistance development. 7-hydroxy coumarin ethyl esters and their corresponding amides have high potency for AKR1C3 and AKR1C2 inhibition. Coumarin amide 3 a possessed IC50 values of 50 nM and 90 nM for AKR1C3 and AKR1C2, respectively, and exhibits 'drug-like' metabolic stability and half-life in human and mouse liver microsomes and plasma. Compound 3 a was employed as a chemical tool to determine pan-AKR1C2/3 inhibition effects both as a …

Discovery Of An Aldo-Keto Reductase 1c3 (Akr1c3) Degrader, Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that confers resistance to clinical androgen receptor signalling inhibitors in castration-resistant prostate cancer. AKR1C3 interacts with ARv7 promoting stabilization. Herein we report the discovery of the first-in-class AKR1C3 Proteolysis-Targeting Chimera (PROTAC) degrader. This first-generation degrader potently reduced AKR1C3 expression in 22Rv1 prostate cancer cells with a half-maximal degradation concentration (DC₅₀) of 52 nM. Gratifyingly, concomitant degradation of ARv7 was …

N.U.R.T.U.R.E: Neutralizing Unsafe Risks Through Unique Responsive Environmental Care, Clara Durante, Easton Duppins, Feven Eskinder, Hiba Mohammed, Faith Niranoluwa

DC Health and Academic Prep Program (DC HAPP)

Environmental factors can be distinguished by physical, chemical, biological, behavioral, and socioeconomic categories. Each category has its own individual effect on human health. These environmental factors play a critical role in determining the health outcomes of pregnancies, influencing both maternal and fetal well-being. This project aims to empower pregnant women by providing comprehensive support and education on mitigating environmental risks. Environmental factors have a significant impact on pregnancy outcomes, specifically among women from lower socioeconomic status (SES) background. Low SES is linked with increased exposure to harmful environmental toxins, high stress levels, limited access to healthcare, which contribute to pregnancy …

Research Priorities For Childhood Apraxia Of Speech: A Long View, Patricia Mccabe, Molly Beiting, Elaine R. Hitchcock, Edwin Maas, Amy Meredith, Angela T. Morgan, Nancy L. Potter, Jonathan L. Preston, Laura Moorer, Pooja Aggarwal, Kirrie Ballard, Laura Baskall Smith, Nicole F. Caballero, Kathryn Cabbage, Julie Case, Susan Caspari, Karen V. Chenausky, Shina Cook, Ewa Grzelak, Maryane Gomez, Aubrie Hagopian, Chantelle Highman, Anne Hodits, Jenya Iuzzini-Seigel, Jillian Levos-Carlson, Barbara A. Lewis, Patricia Mayro, Jyutika Mehta, Gabrielle Miller, Kimberly D. Mory, Elizabeth Murray, Megan S. Overby

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

This article introduces the Journal of Speech, Language, and Hearing Research Special Issue: Selected Papers From the 2022 Apraxia Kids Research Symposium. The field of childhood apraxia of speech (CAS) has developed significantly in the past 15 years, with key improvements in understanding of basic biology including genetics, neuroscience, and computational modelling; development of diagnostic tools and methods; diversity of evidence-based interventions with increasingly rigorous experimental designs; and understanding of impacts beyond impairmentlevel measures. Papers in this special issue not only review and synthesize the some of the substantial progress to date but also present novel findings addressing critical research …

Landscape-Scale Epidemiological Dynamics Of Sars-Cov-2 In White-Tailed Deer, Joshua Hewitt, Grete Wilson-Henjum, Derek T. Collins, Timothy J. Linder, Julianna B. Lenoch, Jonathan D. Heale, Christopher A. Quintanal, Robert Pleszewski, Dillon S. Mcbride, Andrew S. Bowman, Jeffrey C. Chandler, Susan A. Shriner, Sarah N. Bevins, Dennis J. Kohler, Richard B. Chipman, Allen L. Gosser, David L. Bergman, Thomas J. Deliberto, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans for human and animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal and Plant Health Inspection Service and State Natural Resources Agencies to quantify the outbreak dynamics of SARS-CoV-2 in North American white-tailed deer (Odocoileus virginianus; WTD) throughout its range in the United States. Local epidemics in WTD were well approximated by a single-outbreak peak followed by fade out. Outbreaks peaked early in the northeast and mid- Atlantic. Local effective reproduction ratios of SARS-CoV-2 were between …

What Is Known, Unknown, And Needed To Be Known About Damage Caused By Wild Pigs, Kurt C. Vercauteren, Kim M. Pepin, Seth M. Cook, Sophie Mckee, Abigail Pagels, Keely J. Kohen, Ingrid A. Messner, Michael P. Glow, Nathan P. Snow

United States Department of Agriculture Wildlife Services: Staff Publications

Damage assessments provide evidence for initiating and evaluating management programs that protect natural resources and human livelihoods against invasive species. Wild pigs (Sus scrofa) cause extensive damage in their native and non-native ranges, but the extent of current damage and efficacy of management of the damage (i.e., population control of wild pigs, exclusion fencing, etc.) remains poorly described. We conducted a systematic review of physical damage caused by wild pigs to summarize what is known and identify knowledge gaps for damage assessment. Wild pig damage assessments have been overwhelmingly qualitative (84% of studies) and measured differently across studies, …

Tracking Sero-Molecular Trends Of Swine Brucellosis In Hawai'i And The Central Pacific, Thi Hai Au La, Ian A. Mcmillan, Prashant Dahal, Andrew H. Burger, Mahdi Belcaid, Darrin M. Phelps, Samuel M. Goldstein, Vienna R. Brown, Michael H. Norris

United States Department of Agriculture Wildlife Services: Staff Publications

Introduction

Brucellosis is a zoonotic disease of mammals caused by bacterial species of the Brucella genus. The reservoir for disease is typically mammals, with species of Brucella found infecting amphibians, bats, and marine mammals. Brucella spp. can pass directly to humans through contact with infected animals or their products. Brucella spp. can cause chronic debilitating infections in mammals, including humans, and is associated with spontaneous abortions in infected animals, causing reduced fecundity. In Hawai‘i, terrestrial species that could harbor Brucella spp. include swine, cattle, horses, and axis deer among others. The numerous feral swine in Hawai‘i are known to carry …

Ironing Out The Details: Early Detection And Treatment Of Iron Deficiency In A Level 4 Nicu, Rachel Mills

2024

No abstract provided.

Infographic: Equity Opportunities: Income: Need For Dental Care Among Third Grade Students In North Dakota, Shawnda Schroeder

Indigenous Health Faculty Publications

We have third grade students in North Dakota whose dental care needs are not being met. Programs, providers, and initiatives need to focus on providing equal access to preventive dental care supplies and educational resources to support good dental hygiene. Children attending schools where more than 50% of the students are eligible for the national school lunch program (NSLP) have a significantly higher need for early or urgent dental care and a higher rate of rampant decay compared to those attending schools with less than 50% of students eligible for the NSLP

Emergency Department And Dental Clinic Perceptions Of Appropriate, And Preventable, Use Of The Ed For Non-Traumatic Dental Conditions In Hot-Spot Counties: A Mixed Methods Study, Shawnda Schroeder, Judy Beck, Nick Medalen, Anastasia Stepanov

Indigenous Health Faculty Publications

Objectives:Frequency of emergency department (ED) use for nontraumatic dental conditions (NTDC) is a well-researched community health concern. However, research predominately relies on ambulatory ED discharge records. This explanatory sequential mixed methods study reviewed NTDC ED use in hot-spot counties and assessed perceptions around preventable and appropriate use among EDs and dental clinics.

Methods:Tooth pain data (2015-2021) were drawn from State Medicaid, and the Early Notification of Community-Based Epidemics (ESSENCE). NTDC data were compiled using International Classification of Disease, Ninth and Tenth Revisions. Employing extreme case sampling, providers in counties with the highest per-capita NTDC ED use were interviewed.

Results:North Dakota …

Infographic: Oral Health Of North Dakota’S Third Grade Students: Comparing To National Trends, Shawnda Schroeder

Indigenous Health Faculty Publications

No abstract provided.

How Epilepsy Affects A Person’S Quality Of Life, Jasmine Hachem

Student Research Design & Innovation Symposium

The purpose of this project was to design and propose a potential research study. The proposed study examines how epilepsy affects a person's quality of life. The information and data will be gathered from a cross-sectional survey and a literature review. The study's limitations concerning epilepsy and quality of life will also be discussed. Key aspects of the literature review include epilepsy prevalence worldwide, economic burdens, genetic influences, and mental health implications for individuals. Additionally, it discusses educational challenges and socioeconomic disparities. Critical factors, including seizure frequency, comorbidities, and syndrome types, will be examined. The results will provide real-time information …

Advocating Ot Services To Medical Providers, Jazzy Montgomery

Student Research Design & Innovation Symposium

A national survey of physicians, nurse practitioners, physician assistants, and physical therapists was completed in 2023 as part of a research project conducted in the OTD department of JWU. Preliminary findings of the survey showed evidence that occupational therapy (OT) is being underutilized by many medical providers. Incorporating this data into an initial needs assessment, the creation of a continuing education course for occupational therapy practitioners (OTPs) has been the focus of this doctoral capstone project. The results of the survey combined with a scoping review of literature illustrated the need for interprofessional education with medical providers on the scope …

Leadership For Aspiring Healthcare Professionals, Christina Wilson

Student Research Design & Innovation Symposium

There is a lack of diversity in the current occupational therapy (OT) workforce. This lack of representation can make it difficult for minority students to envision themselves as occupational therapy practitioners, impacting their confidence and belief that they can be successful applicants to OT programs. The purpose of this scoping review was to determine the current state of the literature on leadership development for undergraduate students and how this information intersects with minority identities. This scoping review highlighted themes related to confidence, self-reflection, generalizability, and authenticity. This review will inform a capstone project that will focus on developing leadership skills …

Traumatic Brain Injury Service Utilization In Ri, Kaiden Palmieri

Student Research Design & Innovation Symposium

Traumatic brain injuries (TBIs) are a significant cause of morbidity and mortality in the United States each year. In Rhode Island specifically, TBIs are cataloged and patient outcomes are tracked due to the intense level of services utilized during hospital stays and the treatment process. On average, hospital stays due to TBIs are between five and eight days long, and the main causes of TBIs are falls, motor vehicle accidents, and being struck by an object. Due to the nature of TBIs, patients suffering with severe cases usually struggle to recover without long-term support from the medical system and family, …

Too Hot To Thrive: A Qualitative Inquiry Of Community Perspectives On The Effect Of High Ambient Temperature On Postpartum Women And Neonates In Kilifi, Kenya., Adelaide Lusambili, Sari Kovats, Britt Nakstad, Veronique Filippi, Peter Khaemba, Nathalie Roos, Cherie Part, Stanley Luchters, Matthew Chersich, Jeremy Hess

Institute for Human Development, East Africa

Objectives; To understand community perspectives on the effects of high ambient temperature on the health and wellbeing of neonates, and impacts on post-partum women and infant care in Kilifi.

Design; Qualitative study using key informant interviews, in-depth interviews and focus group discussions with pregnant and postpartum women (n = 22), mothers-in-law (n = 19), male spouses (n = 20), community health volunteers (CHVs) (n = 22) and stakeholders from health and government ministries (n = 16).

Settings; We conducted our research in Kilifi County in Kenya’s Coast Province. The area is largely rural and during …

Exploring The Willingness Toward Hiv Immediate Test And Treat Among Msm In Nairobi And Its Environs: A Cross-Sectional Study., Kingori Ndungu, Peter Gichanga, Marleen Temmerman

Centre of Excellence in Women and Child Health

Background: In the test and treat initiative, high-risk populations are screened for human immunodeficiency virus (HIV) infection and start early treatment if diagnosed positive. This study explores factors associated with willingness to initiate testing and immediate treatment among men who have sex with men (MSM) in Nairobi and its environs. The study was informed by a conceptual framework combining the AIDS Risk Reduction Model (ARRM) and the Modified Social Ecological Model.

Methods: This cross-sectional exploratory study targeted MSM (aged 18–60 years) reporting active engagement in anal or oral sex with men in Nairobi and its surrounding areas. Purposive sampling was …

The Effects Of Daily Magnesium Citrate Supplementationon Grip Strength, Carolina Cano, Holly King

Loma Linda University Research Reports

Magnesium (Mg) is thought to play an essential role in physical strength because it catalyzes more than 300 enzymatic reactions involved in energy metabolism and cell growth. Magnesium also aids in the hydrolysis of ATP in glycolysis, acting as a coenzyme in three critical reactions and in crossbridge formation in the muscle contraction cycle. Despite these roles, approximately 60% of the US adult population does not meet the RDA for Mg. Previous studies found inconsistent results on the effects of Mg on physical performance. However, most studies agreed on magnesium's potential as an ergogenic aid.

Effectiveness Of Education For Type 1 Diabetes Patient's Caregivers At Loma Linda University Health, Epiphaneia Juarez

Loma Linda University Research Reports

Diabetes education is essential for patients and families to improve quality of life and minimize the challenges and complications of living with Type 1 Diabetes Mellitus (T1DM). The aim of the research study is to evaluate the knowledge and nutritional practices of caregivers in the management of T1DM in pediatric patients. 20 subjects were recruited at the Loma Linda University Children’s Hospital (LLUCH) Pediatric Diabetes Center before their outpatient T1DM class. A demographic survey, nutrition knowledge survey (NKS), and a 24-hour recall were administered to participants. The Mann-Whitney U test was used to evaluate NKS total score among binary variables …

Assessment Of Nutrition Knowledge And Implementation Of Nutrition Education In Pilots, Tarika Chhabra, Susan Kumon, Savanna Malki, Bryan Ferrell, Cindy Kosch, Edward Bitok, Gurinder Bains, Lida Gharibvand

Loma Linda University Research Reports

This study assessed the effectiveness of a nutrition education program for Certificated Flight Instructors (CFIs). The program consisted of six video modules and briefs on various nutrition topics. Thirty-one CFIs participated in the study, and their nutrition knowledge was assessed before and after the program. The results showed a statistically significant increase in nutrition knowledge scores following the intervention (p < .001). Participants also reported that the program helped them improve their dietary habits. These findings suggest that nutrition education can be an effective way to improve the health and well-being of CFIs and potentially other populations.

Networks Extracted From Nonlinear Fmri Connectivity Exhibit Unique Spatial Variation And Enhanced Sensitivity To Differences Between Individuals With Schizophrenia And Controls, Spencer Kinsey, Katarzyna Kazimierczak, Pablo Andrés Camazón, Jiayu Chen, Tülay Adali, Peter Kochunov, Bhim M Adhikari, Judith Ford, Theo G M Van Erp, Mukesh Dhamala, Vince D Calhoun, Armin Iraji

Faculty, Staff and Student Publications

Schizophrenia is a chronic brain disorder associated with widespread alterations in functional brain connectivity. Although data-driven approaches such as independent component analysis are often used to study how schizophrenia impacts linearly connected networks, alterations within the underlying nonlinear functional connectivity structure remain largely unknown. Here we report the analysis of networks from explicitly nonlinear functional magnetic resonance imaging connectivity in a case-control dataset. We found systematic spatial variation, with higher nonlinear weight within core regions, suggesting that linear analyses underestimate functional connectivity within network centers. We also found that a unique nonlinear network incorporating default-mode, cingulo-opercular and central executive regions …

Unpacking The Influencing Factors Of Telehealth Usage Among Older Consumers, Xiaojing Sheng, Yuri Martirosyan, Khondoker Sayeed Hossain, Reto Felix, Arjun Singh

Marketing Faculty Publications

This research unpacks the challenges and motivations of telehealth usage among older consumers—an understudied population in the extant telehealth literature. Through surveying a sample of older consumers who regularly migrate to winter in the southern areas of the United States, our qualitative analysis uncovers motivations (i.e., convenience, ease of use, efficiency, and a forced option) and challenges (i.e., telehealth limitations, privacy concerns, and lack of trust, access, and skills) of older consumers’ telehealth usage. Further, logistic regression identifies attitude toward telehealth, gender, and health status as significant predictors of telehealth usage behavior. Contributions to theory and practice are also discussed.

2024‐2025 Student Research Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2024-2025 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Combining Spatially Fractionated Radiation Therapy (Sfrt) And Immunotherapy Opens New Rays Of Hope For Enhancing Therapeutic Ratio, Qiuxia Lu, Weisi Yan, Alan Zhu, Slavisa Tubin, Waleed F. Mourad, Jun Yang

Radiation Medicine Faculty Publications

Spatially Fractionated Radiation Therapy (SFRT) is a form of radiotherapy that delivers a single large dose of radiation within the target volume in a heterogeneous pattern with regions of peak dosage and regions of under dosage. SFRT types can be defined by how the heterogeneous pattern of radiation is obtained. Immune checkpoint inhibitors (ICIs) have been approved for various malignant tumors and are widely used to treat patients with metastatic cancer. The efficacy of ICI monotherapy is limited due to the “cold” tumor microenvironment. Fractionated radiotherapy can achieve higher doses per fraction to the target tumor, and induce immune activation …

Intouch Week Of January 1, 2024, New York Medical College

InTouch

• NYMC Looks Back at 2023
• Office of Student Mental Health and Wellness Kickstarts the Wellness Ambassador Program
• NYMC Transforms Workout Experience with Upgrades to Asprinio Fitness Center
• Dr. Daohong Lin Awarded $2,050,000 NIH Grant
• WISE to Empower Women in Science Entrepreneurship
• Notable Speakers Slated to Address the Class of 2024

Residual Effects Of Same Day Lower Extremity Strength Training On Countermovement Jump Performance In Collegiate Women Athletes, Bryan L. Riemann, Matthew J. Johnson, George J. Davies, Andrew A. Flatt

Physical Therapy Faculty Publications

alancing of strength programming intensity with sport demands is necessary to avoid excessive workloads that could inhibit performance. To expand previous jump height focused literature, this study evaluated whether countermovement jump (CMJ) movement strategies, including eccentric characteristics, might reveal CMJ execution strategy shifts to achieve similar afternoon CMJ height following a morning resistance training session (RTS). Fifteen collegiate women’s soccer and volleyball athletes (18–24 years, 73.6 ± 8.4 kg, 1.74 ± 0.19 m) participating in an offseason RTS completed five CMJs during two afternoon sessions (48 h apart), one 4–6 h post morning RTS, and one on a rest day. …

Career Counselors Addressing Social Determinants Of Mental Health In Rural Communities, Kaprea F. Johnson, Alexandra Gant-Howrey, Bisola E. Duyile, Lauren B. Robins, Natese Dockery

Counseling & Human Services Faculty Publications

Career counselors practicing in rural communities must understand and address social determinants of mental health (SDOMH). This conceptual article details the relationships between SDOMH domains and employment and provides evidence-based recommendations for integrating SDOMH into practice through a rural community health and well-being framework. Description of the adaptation of the framework for career counselors in rural communities, SDOMH assessment strategies and tools, and workflow adjustments are included. Conclusions suggest next steps for practice and research.

Adverse Childhood Experiences Of Professional School Counselors As Predictors Of Compassion Satisfaction, Burnout, And Secondary Traumatic Stress, Eric M. Brown, Melanie Burgess, Kristy L. Carlisle, Desmond Franklin Davenport, Michelle W. Brasfield

Counseling & Human Services Faculty Publications

School counselors work closely with students and are often the first point of contact regarding traumatic experiences. It is generally understood that exposure to other individuals’ trauma may lead to a reduction in compassion satisfaction and an increase in secondary traumatic stress, while long-term exposure may result in professional burnout. This study examined the role of school counselors’ (N = 240) own adverse childhood experiences (ACEs) as related to compassion satisfaction, secondary traumatic stress, and burnout. Results indicated that 50% of the professional school counselors in this convenience sample had personal histories of four or more ACEs, which is significantly …

Self-Efficacy Of Undergraduate Human Services Students With Integrated Behavioral Health, Kristy Carlisle, Nic Schmoyer, Danielle Rodgers, Katherina Nako, Richie Kubilus, Zubede Akpakir

Counseling & Human Services Faculty Publications

Human services professionals (HSPs) are poised to contribute to interprofessional collaboration (IPC) in Integrated Behavioral Health (IBH) settings as care enhancers. Interprofessional Education (IPE) effective for training HSPs requires changes or addition to curriculum. The purpose of the current study was to present workshops adjunct to curriculum to HSPs targeting their engagement in IBH settings. The study explored their self-efficacy with IPC after such training using a pre- and post-test design. Results indicated a statistically significant increase in self-efficacy from before and after the workshop. Discussion includes implications for human services educators in using workshops to augment the IPE their …

Unlocking Adolescent Mental Health: Exploring Social Determinants And Depression With The Social Ecological Model, Lauren B. Robins, Danielle Rodgers, Yusuf Barburoglu, Jasmine Griffith, Cearra L. Arnold

Counseling & Human Services Faculty Publications

Employing the robust framework of the Social Ecological Model (SEM) and drawing insights from the Social Determinants of Health (SDOH), this research sought to uncover the interplay between SDOH and mental health among adolescents. With a focus on depression, the study unraveled how various social determinants, both individually and collectively, shape the mental well-being of adolescents, leveraging the rich dataset provided by the National Survey of Children’s Health 2018. Utilizing advanced statistical techniques, the study revealed the predictive power of SDOH in understanding adolescent mental health. Results illuminate the significant influence of social determinants on depression, underscoring the imperative for …