Medicine and Health Sciences Commons^™

Best Practices In The Care Of Older Adults During An Unplanned Acute Observation Stay, Jonny Macias Tejada, Michael Malone

Journal of Geriatric Emergency Medicine

No abstract provided.

A Common Polymorphism In The Intelectin-1 Gene Influences Mucus Plugging In Severe Asthma, Jamie L Everman, Kaharu Sumino, David S. Gierada, Et Al.

2020-Current year OA Pubs

By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC

Distinct Autoantibody Profiles Across Checkpoint Inhibitor Types And Toxicities, Hong Mu-Mosley, Mitchell S Von Itzstein, Farjana Fattah, Jialiang Liu, Chengsong Zhu, Yang Xie, Edward K Wakeland, Jason Y Park, Brad S Kahl, Catherine S Diefenbach, David E Gerber

2020-Current year OA Pubs

Immune checkpoint inhibitors (ICI) are increasingly used in combination. To understand the effects of different ICI categories, we characterized changes in circulating autoantibodies in patients enrolled in the E4412 trial (NCT01896999) of brentuximab vedotin (BV) plus ipilimumab, BV plus nivolumab, or BV plus ipilimumab-nivolumab for Hodgkin Lymphoma. Cycle 2 Day 1 (C2D1) autoantibody levels were compared to pre-treatment baseline. Across 112 autoantibodies tested, we generally observed increases in ipilimumab-containing regimens, with decreases noted in the nivolumab arm. Among 15 autoantibodies with significant changes at C2D1, all nivolumab cases exhibited decreases, with more than 90% of ipilimumab-exposed cases showing increases. Autoantibody …

The Ire1Α/Xbp1 Pathway Sustains Cytokine Responses Of Group 3 Innate Lymphoid Cells In Inflammatory Bowel Disease, Siyan Cao, Jose L. Fachi, Kaiming Ma, Alina Ulezko Antonova, Qianli Wang, Zhangying Cai, Randal J. Kaufman, Matthew A. Ciorba, Parakkal Deepak, Marco Colonna

2020-Current year OA Pubs

Group 3 innate lymphoid cells (ILC3s) are key players in intestinal homeostasis. ER stress is linked to inflammatory bowel disease (IBD). Here, we used cell culture, mouse models, and human specimens to determine whether ER stress in ILC3s affects IBD pathophysiology. We show that mouse intestinal ILC3s exhibited a 24-hour rhythmic expression pattern of the master ER stress response regulator inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1). Proinflammatory cytokine IL-23 selectively stimulated IRE1α/XBP1 in mouse ILC3s through mitochondrial ROS (mtROS). IRE1α/XBP1 was activated in ILC3s from mice exposed to experimental colitis and in inflamed human IBD specimens. Mice with Ire1α deletion …

A Systematic Review To Determine The Effect Of Strategies To Sustain Chronic Disease Prevention Interventions In Clinical And Community Settings: Study Protocol, Edward Riley-Gibson, Byron J Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: The primary purpose of this review is to synthesise the effect of strategies aiming to sustain the implementation of evidenced-based interventions (EBIs) targeting key health behaviours associated with chronic disease (i.e. physical inactivity, poor diet, harmful alcohol use, and tobacco smoking) in clinical and community settings. The field of implementation science is bereft of an evidence base of effective sustainment strategies, and as such, this review will provide important evidence to advance the field of sustainability research.

METHODS: This systematic review protocol is reported in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) checklist. Methods …

Forgotten Clientele: A Systematic Review Of Patient-Centered Pathology Reports, Eric Steimetz, Elmira Mostafidi, Carolina Castagna, Raavi Gupta, Rosemary Frasso

College of Population Health Faculty Papers

CONTEXT: Patient portals, designed to give ready access to medical records, have led to important improvements in patient care. However, there is a downside: much of the information available on portals is not designed for lay people. Pathology reports are no exception. Access to complex reports often leaves patients confused, concerned and stressed. We conducted a systematic review to explore recommendations and guidelines designed to promote a patient centered approach to pathology reporting.

DESIGN: In consultation with a research librarian, a search strategy was developed to identify literature regarding patient-centered pathology reports (PCPR). Terms such as "pathology reports," "patient-centered," and …

Tongue Posture And Effects On Overall Health: A Dental Hygiene Curriculum Assessment, Kelly Brackeen

Dental Hygiene ETDs

Research shows that proper tongue posture can impact quality of life, stability of the mouth, and have effects on overall wellness. Dental hygienists have a unique position to be able to identify tongue placement disorders. The objective of this study was to identify to what extent dental hygiene students are being taught orofacial myofunction during dental hygiene education. A survey link was emailed to all program directors in the United States regarding the teaching of orofacial myofunction within their respective programs. Using descriptive analysis, 44%, or less than half reported that their program curriculum includes teaching students proper resting position …

A Mind-Body Intervention To Improve Physical Activity For Patients With Chronic Hip-Related Pain: Protocol For A Mixed Methods Study., Kate N Jochimsen, Kristin R Archer, Robin A Pollini, Robert A Parker, Nomin Enkhtsetseg, Cale A Jacobs, Ana Maria Vranceanu

Psychiatry Faculty Publications

BACKGROUND: Pain and dysfunction persist for most patients following hip-related pain treatment. Additionally, individuals with hip-related pain are typically less physically active than individuals without hip pain, despite evidence that regular physical activity reduces chronic musculoskeletal pain. Poor psychological health is common in patients with hip-related pain and further reinforces low physical activity. Mind-body interventions can improve psychological health and activity levels but have yet to be integrated to provide comprehensive, psychologically informed care for patients with hip-related pain. Thus, we are using the NCCIH intervention development framework to develop Helping Improve PSychological Health (HIPS), a novel, multimodal mind-body intervention …

How Financial Beliefs And Behaviors Influence The Financial Health Of Individuals Struggling With Opioid Use Disorder, James R Langabeer, Francine R Vega, Marylou Cardenas-Turanzas, A Sarah Cohen, Karima Lalani, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

The surge in opioid use disorder (OUD) over the past decade escalated opioid overdoses to a leading cause of death in the United States. With adverse effects on cognition, risk-taking, and decision-making, OUD may negatively influence financial well-being. This study examined the financial health of individuals diagnosed with OUD by reviewing financial beliefs and financial behaviors. We evaluated quality of life, perceptions of financial condition during active use and recovery, and total debt. We distributed a 20-item survey to 150 individuals in an outpatient treatment program for OUD in a large metropolitan area, yielding a 56% response rate. The results …

High-Density Genetic Map Construction And Qtl Mapping Of A Zigzag-Shaped Stem Trait In Tea Plant (Camellia Sinensis), Dingding Liu, Yuanyuan Ye, Rongjin Tang, Yang Gong, Si Chen, Chenyu Zhang, Piao Mei, Jiedan Chen, Liang Chen, Chunlei Ma

Faculty, Staff and Student Publications

The highly unique zigzag-shaped stem phenotype in tea plants boasts significant ornamental value and is exceptionally rare. To investigate the genetic mechanism behind this trait, we developed BC1 artificial hybrid populations. Our genetic analysis revealed the zigzag-shaped trait as a qualitative trait. Utilizing whole-genome resequencing, we constructed a high-density genetic map from the BC1 population, incorporating 5,250 SNP markers across 15 linkage groups, covering 3,328.51 cM with an average marker interval distance of 0.68 cM. A quantitative trait locus (QTL) for the zigzag-shaped trait was identified on chromosome 4, within a 61.2 to 97.2 Mb range, accounting for a phenotypic …

Physical Activity In Underserved Preadolescents: Characterization Of Accumulation And Patterns, Alma I. Behar, Matthew T. Mahar, Gregory Norman, John P. Elder, Michael Pratt, Patricia Dionicio, Noe C. Crespo

International Journal of Physical Activity and Health

Objectives: The increasing rates of physical inactivity and sedentary behaviors among youth are a significant public health concern. The greatest disparities in physical activity (PA) are experienced by underserved (racial/ethnic minority, low-income) youth. This study aimed to characterize accelerometer-measured PA behaviors in a sample of low-income, predominantly Latino, preadolescents. Methods: Participants wore wrist worn GENEActiv accelerometers for 7 days. PA levels were classified as sedentary (< 50 mg), light (50-150 mg), moderate (> 150-500 mg), vigorous (> 500 mg), and MVPA (≥ 150 mg). Time spent in PA levels and sedentary time (ST), prevalence of meeting MVPA guidelines, and PA volume were estimated from accelerometer data. Three-way …

Beyond The Task: Developing A Tool To Measure Workplace Characteristics That Affect Cognitive Load And Learning, Sarah Blissett, Sebastian Rodriguez, Atif Qasim, Patricia O'Sullivan

Department of Medicine Faculty Papers

PURPOSE: Educators lack tools to measure the workplace characteristics that learners perceive to affect learning. Without a tool that encompasses the social, organizational, and physical components of workplace learning environments (WLEs), it is challenging to identify and improve problematic workplace characteristics. Using echocardiography WLE, this study developed a tool to measure workplace characteristics that cardiology fellows perceive to affect learning.

METHOD: The Workplace-Cognitive Load Tool (W-CLT) was developed, which encompasses 17 items to measure workplace characteristics that could affect perceived cognitive load and learning. Exploratory factor analysis was used to identify the most parsimonious structure. A total of 646 cardiology …

Sexual Function After Gender Affirming Surgery, Alicia R. Castellanos, Rachel Pope

Faculty Scholarship

Purpose of Review: Sexual function and satisfaction in the transgender community is a nascent field with a paucity of data due to the fast paced nature of improving upon surgical technique and variety of patient experiences. The authors aim to review the current literature for areas of success as well as areas of improvement in order to better the sexual health of the transgender community. Recent Findings: Gender dysphoria is a feeling of distress experienced by those whose gender assigned at birth is not in line with their gender identity. While social transition to the desired gender can suffice for …

Activation Of Interleukin 33-Nfκb Axis In Granulosa Cells During Atresia And Its Role In Disposal Of Atretic Follicles, Jean Wu, Colin Carlock, Kiana Tatum, Junbo Shim, Cindy Zhou, Yahuan Lou

Faculty, Staff and Student Publications

It has been previously shown that the cytokine interleukin 33 is required for two processes, i.e., autophagic digestion of granulosa cells and recruitment of macrophages into atretic follicles, for full disposal of atretic follicles. Now, this study shows that activation of interleukin 33-suppression of tumorigenicity 2-Nuclear Factor ĸB (NFκB) axis in granulosa in early atretic follicles may regulate those two events. Injection of human chorionic gonadotropin has been shown to induce a transient peak of interleukin 33 expression with synchronized atresia. In this model, interleukin 33-independent expression of suppression of tumorigenicity 2 in granulosa cells was detected in early atretic …

Addressing Or Reinforcing Injustice? Artificial Amnion And Placenta Technology, Loss-Sensitive Care And Racial Inequities In Preterm Birth, Sophie L Schott, Faith Fletcher, Alice Story, April Adams

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

Assessing Trends In Cochlear Implant Recipients' Quality Of Life Score Over Time, Rebecca Civil

Dissertations, 2020-current

This study investigates changes in subjective health-related quality of life (HRQoL) among cochlear implant (CI) recipients over extended periods post-implantation. While existing literature primarily focuses on the initial or short-term improvements in QoL post-implantation compared to pre-implantation, this study looks into the stability and potential decline of QoL over time. Although the literature provides limited evidence on longitudinal trends in QoL among CI recipients over extended periods exceeding 12 months post-implantation, that limited evidence suggests a trend of decline in QoL scores, even as objective audiological measures tend to stay consistently high in the same population. Utilizing data from 25 …

“Neur-Aud-Diversity”: Young Adults With Adhd Are More Impulsive And Can Be Accurately Selected From Their Neurotypical Peers Using False Alarm Rates In Masked And Unmasked Auditory Tasks, Katelyn Hobbs

Dissertations, 2020-current

Objective diagnostic measures are desired for those with ADHD (attention deficit/hyperactivity disorder) to overcome current subjective measures. Listeners with ADHD are more impulsive than their neurotypical peers (those without a neurological disorder). Greater impulsivity can lead to lower thresholds on an informational masking task. It was hypothesized that people with ADHD would have lower thresholds on an informational masking task, however, no significant difference was found between the groups’ thresholds (t ₄₀=.49, p=.62, Cohen d=.16). A significant difference was found when comparing the initial false alarm rates from the long testing period with the final false alarm rates (p=.035, …

The Effect Of Dance Training On The Vor During The Video Head Impulse Test, Miranda Scalzo

Dissertations, 2020-current

The vestibulo-ocular reflex (VOR) is essential to maintain clear vision during head movements and can be assessed through the head impulse paradigm (HIMP). The suppression head impulse paradigm (SHIMP) is used to quantify the ability to suppress the VOR. MacDougall et. al. (2016) demonstrated that SHIMP gain is decreased compared to HIMP gain values in healthy adults. Previous research has supported the idea that vestibular trained athletes, such as dancers, have an enhanced capability of suppressing the VOR than those without vestibular training. The objective of this study was to assess VOR suppression capabilities at increased velocities, similar to what …

The Effect Of Listening Level On Listening Effort: A Pupillometry Study, Noelle Elizabeth Steele

Dissertations, 2020-current

Listening in adverse conditions such as in the presence of background noise or at a low intensity level can require additional listening effort. While the relationship between signal to noise ratio and listening effort has been reported previously, there is a gap in the literature on the effect of listening at different levels on listening effort. In the present study, five young, normal-hearing listeners were tested for speech understanding at two presentation levels (35 dB and 65 dB) under three signal to noise ratio conditions (0, -3, and -6 dB). Peak pupil dilation was measured using a Tobii T60 XL …

Magnitude Estimations Of Angular Motion: Test-Retest Reliability, Elizabeth C. Pahygiannis

Dissertations, 2020-current

Dizziness and imbalance are one of the most common complaints of people 65 years and older, as it affects 20-30% of this population and puts one at a higher risk of falling (Iwasaki & Yamasoba, 2015). Vestibular impairments are identified through measures of vestibular reflexes such as the VOR. However, the extent of impairment observed through the VOR may not correlate with the patient’s perceptions of their symptoms (Kobel et al., 2021).A large portion of patients with vestibular symptoms cannot be diagnosed with the testing that is currently available (Agrawal et al., 2009). Magnitude estimation is a psychophysics technique used …

Assessing The Effects Of Emg Target Levels On Cvemp Thresholds, Melanie Johnson

Dissertations, 2020-current

Cervical vestibular evoked myogenic potentials (cVEMP) measure function of the saccule and inferior vestibular nerve by evoking inhibitory electromyogram (EMG) responses from the sternocleidomastoid muscle using short duration stimulation. Previous research has shown that cVEMP amplitude increases relative to EMG target level and latency remains constant, yet there is little to no research demonstrating the relationship between EMG target level and cVEMP threshold. The objective of this study is to determine the effects of EMG activation on cVEMP thresholds and assess whether patients who generate larger tonic EMG during cVEMP testing have lower cVEMP thresholds. cVEMPs were recorded in 20 …

“Neur-Aud-Diversity”: Assessing Adhd Through Speech-On-Speech Masking, Rebecca Hales

Dissertations, 2020-current

Attention deficit hyperactivity disorder (ADHD) is an executive functioning disorder which can be difficult to diagnose. The current diagnosis process relies on observations and subjective reports, resulting in individuals being misdiagnosed or have delays in receiving a proper diagnosis. Differences in auditory processing have been observed between neurotypical (NT) and ADHD individuals via neurophysiological measures, so this study aims to see if those differences can be translated into objectively measurable differences in more cost-effective behavioral measures.

While seated in front of an array of speakers, NT and ADHD participants were asked to listen for verbal directions to complete a task …

A Case Study On The Effects Of Pregnancy On Expiratory Flow Limitation (Efl) And Operating Lung Volumes During Exercise, Hannah Young

Masters Theses, 2020-current

The purpose of this study was to examine the effects of pregnancy on expiratory flow limitation (EFL) and operating lung volumes (end expiratory lung volume and end inspiratory lung volume; EELV and EILV) during exercise, with an exploratory aim to assess differences in the above measures between exercise modalities. EFL has been shown to occur in several other subgroups but has never been studied in pregnant individuals. We followed one 35-year-old pregnant subject throughout her pregnancy, completing exercise and pulmonary testing every other week from 8 weeks gestation to 38 weeks gestation, and once again ~8 weeks postpartum. Testing was …

Characterizing The Expression Of The Sphingosine 1-Phosphate Pathway In Injury And Post-Traumatic Fibrosis, Nicole Cubbage

Masters Theses, 2020-current

Following injury, tissue repair allows for the restoration of the architecture and function of the injured tissue, while tissue replacement is characterized by severely damaged or non-regenerable tissue that is repaired by the laying down of extensive connective tissue, also known as fibrosis. The fibrotic process should be arrested at its early stage to have the greatest impact on preventing or reversing associate sequelae and promoting the regeneration of normal tissue. Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, has emerged as a pathway that may be involved in fibrosis. Most of S1P’s actions are mediated through the …

Assessing The Effectiveness Of Treatment Programs Among Veterans With Opioid Use Disorder In New York State, Olatoye Oluwaseyi Itaniyi

Walden Dissertations and Doctoral Studies

New York State (NYS) is home to millions of veterans and has the fifth-largest veteran population in the country. Veterans represent a vulnerable population and are at higher risk for mental and physical health struggles. The focus of this quantitative study was to assess if there is any significant difference between pre- and post-OUD 24-hour detoxification treatment services, residential/rehabilitation treatment services, ambulatory outpatient treatment services, frequency of opioid use at discharge, and mental disorder among veterans with opioid use disorder in NYS when controlling for age, gender, race, and marital status. The study utilized the harm reduction framework and the …

Instructor Characteristics That Increase Self-Efficacy In Nursing Students, Kaycee Jodean Jacobson

Walden Dissertations and Doctoral Studies

With the current nursing shortage, finding ways to increase nursing retention in graduate nurses can help ease the shortage. Self-efficacy is a factor that contributes to an individual’s well-being and can affect their professional accomplishments. The purpose of this study, guided by Bandura’s theory of self-efficacy, was to identify instructor characteristics that may impact student perceived self-efficacy in the clinical setting. Bandura identified self-efficacy as a factor that contributes to an individual’s well-being as a whole and can affect their professional accomplishments. A sample of 19 nursing students who were enrolled in a clinical course were recruited and completed the …

Knowledge And Perceptions Of Pharmacogenomics Among Mississippi Pharmacists, Nicholas Dean

Honors Theses

Pharmacogenomics (PGx), an area of study that relates a patient’s genetics to the medicines they take, has been shown to be an effective alternative to trial-and-error prescribing. Despite the benefits pharmacogenomics may bring, pharmacists, while optimistic about the practice, appear to lack knowledge and access to other resources to bring PGx to the front lines of practice. Therefore, the purpose of this study is to assess Mississippi pharmacists’ knowledge and attitudes about PGx, readiness for practice of PGx, their education needs for PGx, their application of PGx in practice, and their perception of the ethics of PGx practice.

A cross-sectional …

Role Of Dunc-13 Isoforms In Alcohol Sensitivity In Drosophila, Makenzie Havard

Honors Theses

Functional alcohol tolerance is an adaptation made by the nervous system to high doses of alcohol, and is seen by a significant reduction in sensitivity to this drug. This tolerance is a significant contributing factor in the progression to Alcohol Use Disorders. A major goal of alcohol research is to understand how alcohol induces this tolerance. Dunc13 is a presynaptic active zone protein essential in synaptic vesicle docking and priming. Alcohol binds to the C1 domain of Dunc13 at physiological concentrations, which inhibits Dunc13 from binding Diacylglycerol. This inhibition is predicted to reduce Dunc13 activity and presynaptic activity. Yet, genetically …

Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Cameron Delaney Hillman, Macey Jewell Ross, Lydia Noel Miller

Honors Theses

As Senior Biomedical Engineering students at the University of Mississippi, we, Lainey Hillman, Lydia Miller, and Macey Ross, are required to complete a final senior capstone for our department. This project aims to provide a solution to a current unmet clinical need in the healthcare industry, thus our team sought to improve the lack of transportability of sling lifts. The current sling lifts on the market display numerous issues: heavy, bulky, use confined to certain areas, and use specific for only one type of transportation. To combat these problems, we designed a sling lift that was lightweight, collapsible, safe, and …

Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Macey Jewell Ross, Cameron Delaney Hillman, Lydia Noel Miller

Honors Theses

As Senior Biomedical Engineering students at the University of Mississippi, we, Lainey Hillman, Lydia Miller, and Macey Ross, are required to complete a final senior capstone for our department. This project aims to provide a solution to a current unmet clinical need in the healthcare industry, thus our team sought to improve the lack of transportability of sling lifts. The current sling lifts on the market display numerous issues: heavy, bulky, use confined to certain areas, and use specific for only one type of transportation. To combat these problems, we designed a sling lift that was lightweight, collapsible, safe, and …