Medicine and Health Sciences Commons^™

Conservative Management Of A Rare Clinical Phenomenon: Paraspinal Compartment Syndrome - A Review Of Existing Literature., Mark Lagreca, Arash Badragheh, Nathan Jones, Thomas Falconiero, Brian Danshaw

Orthopedic Surgery Resident Research

INTRODUCTION: This review of case series and case reports explores conservative management strategies for paraspinal compartment syndrome (PCS), a rare clinical condition. Extremity compartment syndrome has been shown to be managed most effectively with emergent surgical release of the fascial compartment. Given the rarity of PCS and the paucity of research in the literature, some authors have suggested the possibility of conservative treatment. There has been no study to date that has specifically investigated the cases of non-operative management of PCS.

MATERIALS AND METHODS: There are 16 case reports in the literature with 22 cases of PCS treated conservatively. The …

Pacific Rxtracts - December 2024, Pacific Rxtracts

Pacific RxTracts

Articles

• Attruby: A Promising Treatment for Transthyretin Amyloid Cardiomyopathy
• Triple Threat: GMRx2, An Emerging Low-Dose Triple Pill For Hypertension
• New Treatment for Hemophilia A or B
• Breaking the Placebo Barrier: FDA Review Challenges Effectiveness of Popular Decongestant
• Exploring Bempedoic Acid: Potential Benefits for Statin-Intolerant Patients and Liver Health
• The Flu Vaccine: Meeting You Where You Are
• Unique Application of Statins for Radiotherapy-Induced Cardiotoxicity
• One Shot, Two Solutions: How Semaglutide Combats Obesity and Knee Osteoarthritis

The Role Of Nurses In Environmental Sustainability, Olivia Monroe

Honors Projects

This project explores the current literature on pollution originating from the United States healthcare sector, with emphasis on greenhouse gas emissions and waste production. Strategies healthcare organizations are implementing to reduce their pollution and actions nurses can take to support these initiatives are discussed.

Derivation Of A Novel Antimicrobial Peptide From The Red Sea Brine Pools Modified To Enhance Its Anticancer Activity Against U2os Cells, Mona Elradi, Ahmed I. Ahmed, Ahmed M. Saleh, Khaled M.A. Abdel-Raouf, Lina Berika, Yara Daoud, Asma Amleh

Faculty Journal Articles

Cancer associated drug resistance is a major cause for cancer aggravation, particularly as conventional therapies have presented limited efficiency, low specificity, resulting in long term deleterious side effects. Peptide based drugs have emerged as potential alternative cancer treatment tools due to their selectivity, ease of design and synthesis, safety profile, and low cost of manufacturing. In this study, we utilized the Red Sea metagenomics database, generated during AUC/KAUST Red Sea microbiome project, to derive a viable anticancer peptide (ACP). We generated a set of peptide hits from our library that shared similar composition to ACPs. A peptide with a homeodomain …

Machine Learning And Evaluation Of Diabetes Risk Using 2022 Brfss Data, Addie Weaver

Masters Theses

This research analyzes Behavioral Risk Factor Surveillance System data from 2022 with three machine learning models, Neural Network, Random Forest, and Support Vector Machine, to determine and compare the models’ accuracy rate of diabetes prediction. Principal Component Analysis was employed to determine principal factors of diabetes risk. Results show that the Neural Network is most accurate at 90.09 percent at predicting diabetes. Factors increasing diabetes risk include alcohol consumption, smoking, and self-perceived mental and physical health.

Successful Limb Salvage In A Severe Diabetic Foot Infection: A Case Study Of Aggressive Surgical Intervention And Grafting Technique, Stephanie N. Campbell, Heather V. Tran, Nikita V. Gambhir

School of Podiatric Medicine Publications

No abstract provided.

Biomechanics And Clinical Implications Of Fontan Upsizing, Vijay Govindarajan, Akshita Sahni, Emily Eickhoff, Peter Hammer, David M Hoganson, Rahul H Rathod, Pedro J Del Nido

Faculty, Staff and Student Publications

Background: The Fontan operation, a palliative procedure for single ventricle patients, has evolved to improve outcomes and reduce complications. While extracardiac conduit (ECC) is favored for its simplicity and potential hemodynamic benefits, concerns arise about conduit size adequacy over time. Undersized ECC conduits may cause hemodynamic inefficiencies and long-term complications, while oversizing can lead to flow disturbances, stagnation, and thrombosis, necessitating surgical revision or upsizing to optimize hemodynamics.

Objectives: The study aimed to predict the impact of upsizing by developing a patient-specific workflow using cardiac magnetic resonance-based imaging and computational fluid dynamics to assess Fontan hemodynamic changes and determine the …

The Ethics Of Vulnerability In Health Care, Hannah Dieterle

Electronic Theses and Dissertations

This dissertation seeks to address vulnerability within clinical healthcare settings. Currently, clinical vulnerability is underrecognized and insufficiently researched which leads to the perpetuation of negative health outcomes for vulnerable populations. Specifically, there is a lack of a consistent and universal definition of vulnerability which has built a shaky foundation on which to discuss vulnerability. This dissertation begins to address these issues and increase awareness on clinical vulnerability due to some populations experiencing the devastating effects of vulnerability at a higher and disproportionate rate when compared to other populations. There is a clear need for increased attention from ethicists and medical …

Chronic Illness Education 2024: Incremental Diet And Activity Changes To Improve Cardiovascular Health, Carter Dunaway, Jonah Kornbluh, Kit Tran, Naya Pabla, Olivia Jeakle, Zaid Saadeh

Patient Education Projects

No abstract provided.

Lgbtq+ College Students’ Willingness To Access Campus Health Services At A Midsized, Urban Christian University: A Study On Disparities, Samual J. Piatt, Christian Williams, Frecia Gonzalez

SPARK Symposium Presentations

Introduction

LGBTQ+ college students face inequitable health outcomes in both mental health and physical health versus non-LGBTQ+ counterparts (The Trevor Project, 2023), (Brittain et Dinger, 2015). LGBTQ+ students experience higher unwillingness and disparities in care access due to negative perceptions of and experiences with UHS providers (Hood et al, 2019). Research indicates that better provider LGBTQ+ cultural awareness contributes to a more affirming space which in turn benefits LGBTQ+ healthcare (Parmenter et al, 2020), (Prasad et al, 2023).

Methods

A 2024 cross-sectional study assessed the comfort levels of LGBTQ+ college students in accessing student health services, explore how affirming healthcare …

Tenecteplase For Acute Ischemic Stroke: Insights From A Large Community Teaching Hospital, Ithar Alsarraf, Jennifer Pilotto, Rebecca E. Baker, Emily Reich

Posters

Acute Ischemic Stroke (AIS) is a leading cause of disability and death in the United States, requiring urgent treatment1,2; earlier treatment improves patient outcomes.

Fibrinolytic agents including alteplase and tenecteplase (TNK) reduce long-term disability in AIS but are associated with hemorrhagic risks3,4.

As of January 2024, Corewell Health East hospitals updated their guidelines that TNK would be the first line agent in the treatment of AIS.

Alteplase is the only approved agent for AIS, but TNK shows similar effectiveness along with shorter preparation and administration time which may ultimately improve door-to-needle time2 .

Careful consideration of patient characteristics is important …

October / November / December 2024, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the October - November - December issue of Rural Rocks from the SWOSU College of Pharmacy.

Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven

Open Access Theses & Dissertations

Continuous overactivation of myofibroblasts leads to excessive deposition of profibrotic proteins, which in turn causes tissue stiffness and, ultimately, organ failure. One of those proteins, Cadherin-11 (CDH11), is reported to be overexpressed in the tissue of fibrotic skin, specifically on myofibroblasts. Similarly, chronic inflammation drives fibrosis progression in autoimmune-related illnesses like systemic sclerosis (SSc). Therefore, it is hypothesized that CDH11 could be a target for cell-specific delivery of antifibrotic therapies to fibrotic skin tissue. Here, a CDH11 peptide conjugated liposome loaded with Tofacitinib, a JAK inhibitor, was developed to understand the potential of targeted therapies to treat skin fibrosis. The …

“Breaking Barriers: Empowering African Youth Through Implementation Of A Therapeutic Patient Education Program For Juvenile Idiopathic Arthritis”, Wafa Hamdi, Angela Migowa, Hanene Lassoued Ferjani, Alia Fazaa, Saoussen Miladi, Kaouther Maatallah, Kawther Ben Abdelghani, Ayodele Faleye

Paediatrics and Child Health, East Africa

Introduction: Patient education is crucial in managing chronic diseases like Juvenile Idiopathic Arthritis (JIA). Traditional methods such as videos and brochures often fail to maintain long-term knowledge retention. Therapeutic Patient Education (TPE) offers a more effective, patient-centered approach.

Objective: PAFLAR aimed to implement a TPE program with a “train the trainers” masterclass to ensure effective delivery and improve outcomes for children with JIA.

Methods: PAFLAR’s TPE program was designed through a focus group, involving a literature review and strategic planning for the implementation step. The program includes specialized training for healthcare professionals enhancing their abilities to deliver …

Tackling Fall Risk In Geriatric Dementia Patients: The Impact Of Medication Reconciliation Relating To Polypharmacy & Falls, Jenl Khristen Ang

Nursing | Student Research Posters

Over half of the elderly population are taking three or more prescription drugs daily. For those aged 65 and older, polypharmacy, taking five or more medications, is common due to conditions like hypertension, heart disease, arthritis, and diabetes (CDC, 2019). Managing these medications can be challenging, especially for those with dementia, who may also take drugs for conditions such as diabetes or depression, which can worsen cognitive impairment (Chippa & Roy, 2023). The complex regimens and increased sensitivity to medications heighten the risk of adverse events, particularly falls, a major cause of injury, hospitalizations, and loss of independence in older …

Domestic Violence And Mental Health In Pregnant Women, Arabella M. Co

Nursing | Student Research Posters

Background: Domestic violence can include verbal, emotional, and physical abuse, which can lead to long-term mental health disorders such as stress, anxiety, or post-traumatic stress disorder. Purpose: This research includes a literature review, as well as a proposed research design to examine the significance of intimate partner violence in relation to mental health by implementing screening methods and interventions. Method: Participants will be recruited from prenatal clinics around the Bay Area. A quantitative, randomized, controlled-trial cohort study will investigate the effectiveness of the Pregnancy Risk Assessment Monitoring Systems (PRAMS). A screening tool used in determining intimate partner violence within the …

Medical Aid In Dying Education For Hospice Nurses, Ian K. Woo

Nursing | Student Research Posters

Background: Medical aid in dying (MAID) is an option surrounding end-of-life care for hospice patients. This process gives patients the autonomy to end their life during the time and location of their choosing. MAID is growing in legalization and practice across the US. However, many nurses feel uncomfortable or unprepared when providing care for patients contemplating it. Hospice nurses should have confidence in their ability to care for patients through the process of MAID. Objective: To evaluate the effectiveness of education in strengthening new hospice nurses’ ability to care for patients through the process of MAID. Method: The research will …

Genetic Testing And Anorexia Nervosa: Knowledge, Attitudes And Awareness, Sarah Ramsay

All Dissertations

This dissertation consists of three parts, each building on the results of the former, evaluating the treatment and research of anorexia nervosa (AN) from a healthcare genetics perspective. These three parts are bookended by an introduction and a conclusion summarizing key findings and providing suggestions for future work. First, in order to assess how Severe and Enduring Anorexia Nervosa (SE-AN) is defined in the literature, and inclusion of those with SE-AN in genetics research, a comprehensive literature review was performed. The review found a lack of consistent identification and inclusion of the SE-AN subtype in AN genetic study participants. Second, …

Exploring The Contribution Of Mobile Money To The Well-Being Of Rural Tanzanian Villagers And Assessing Their Readiness To Adopt A Similar Model To Advance Their Healthcare Access An Exploratory Study, Sr. Magdalena P. Chubwa

Seton Hall University Dissertations and Theses (ETDs)

Background: Healthcare for rural villages in Tanzania has always been rudimentary. Lack of the infrastructure and poverty are among the many obstacles facing this population’s access to healthcare. While, the rise of telehealth has improved access to healthcare in many parts of the world, its use in rural Tanzania has been extremely limited to poor internet access. However, given the availability of non-internet connected mobile phones in rural Tanzania, the potential to use this devise to improve healthcare access exists. Individuals using mobile phones for financial transactions may be motivated to access healthcare via telehealth by using their non-internet connected …

An Extensive Exploration Of Generalist Microbotryum Species Through Host Interactions., Emilee Walters

College of Arts & Sciences Senior Theses

The Microbotryum species complex is a group of fungi, commonly known as anther smuts. Anther smuts are plant parasites that must invade a host plant in order to fulfill their life cycle. As the Microbotryum fungus grows, it sterilizes the host plant, such that infected plants produce fungal teliospores instead of pollen on the male reproductive organs and female reproductive structures do not mature. Microbotryum usually exists as a specialist species, however, there is evidence that several species of anther smuts can exist as generalist species. Comparisons of the infection process and the resulting response of both parasite and host …

Addressing The Public Health Concern Of Maternal Mortality In Houston, Texas, Lucy Couture

Dissertations and Theses (Open Access)

Maternal mortality remains a pressing public health concern in the United States, with disproportionate consequences for marginalized communities. Despite being a developed nation, the U.S. reports one of the highest maternal mortality rates among its peers, with approximately 80% of maternal deaths deemed preventable. Texas reflects this national crisis, particularly affecting Black women, whose maternal mortality rate is significantly higher than that of other racial and ethnic groups. This thesis explores maternal mortality trends in Houston, Texas, analyzing the roles of systemic inequities, social determinants of health, and disparities in access to quality care. Drawing on data from the Texas …

Editorial – Dec 2024, Edwin Van Teijlingen, Abeer Musaddique, Rafat Jan

Journal of Asian Midwives (JAM)

No abstract provided.

Enhancing Respiratory Health With Post-Yoga Exercises During Pregnancy, Hiromi Ito-Kaneko, Masayuki Uehara

Journal of Asian Midwives (JAM)

Pregnancy results in enlarged uterus and diaphragm elevation, which may cause shallow breathing. These changes often cause nocturnal dyspnea, chest discomfort, and difficulty breathing, especially late pregnancy. Training of pregnant women for extending their exhalation reduces suffocation during movement, increasing comfort during pregnancy. In prenatal yoga, deep breathing is practiced and has a relaxing effect.
The purpose of this study is to determine whether yoga exercises during pregnancy improves exhalation length.
We enrolled 152 pregnant women and used a chronograph to measure their exhalation length pre- and post-yoga exercises and compared exhaled breath length by gestational age group. The pre-yoga …

The Role Of Midwives In Achieving The Global Sustainable Development Goals, Bakhtawar Muhammad Hanif Khowaja Bk, Elizabeth K. Darling

Journal of Asian Midwives (JAM)

The sustainable development goals (SDGs) provide a comprehensive framework for global development. Midwives are playing an important role in achieving the targets of the world’s priority agendas. They are actively involved in achieving the targets of SDG#2 by providing education to women on their nutritional requirements, supporting postnatal women with breastfeeding, and educating communities on the use of clean water, sanitation, and hygiene management. Beyond counseling and educating communities on nutrition and hygiene management, they are also involved in improving other health-related outcomes that are indicators for SDG#3, such as improving maternal and child immunization, counseling mothers on tobacco …

Factors Influencing Colostrum Avoidance In Developing Countries: Insights From A Literature Review, Muhammad Zeeshan Aslam, Jonathan Johnson, Marina Baig, Abeer Musaddique

Journal of Asian Midwives (JAM)

Introduction: Colostrum is a thick, sticky, clear and yellowish-coloured milk produced after the first few hours of birth until day 3. It consists of vitamin A, proteins, lipids, potassium, and maternal antibodies, including lactoferrin, immunoglobulin, growth factors and antimicrobial factors. Colostrum avoidance is the practice of squeezing out, pumping, and discarding the first milk. Various studies have reported colostrum avoidance worldwide, but its prevalence is higher in developing countries. Every day, approximately 3000 to 4000 infants die due to diarrhea and respiratory infections in developing countries, and one of the leading causes is colostrum avoidance. Infants are unable to take …

Compassionate Care In Times Of Loss: Unraveling Nurses’ And Midwives’ Perspectives To Assess Preparedness In Stillbirth: A Review Article, Nabila Salim Ali, Arusa Lakhani, Salma Rattani, Sidrah Nausheen

Journal of Asian Midwives (JAM)

Perinatal death, including stillbirth, is a tragic event that significantly impacts holistically the well-being of affected families, particularly in low-middle-income countries (LMICs), where the incidence is alarmingly high. This paper explores the profound effects of stillbirth on parental mental health, emphasizing the associated risks of mental health challenges and examining the crucial role of nurses and midwives in managing stillbirth, from providing immediate emotional support to facilitating long-term coping strategies. Despite their essential role, they face significant challenges, including inadequate training, emotional burdens, and the need for culturally sensitive care practices. Through a comprehensive review of the literature, this paper …

Improve The Referral System Of Health Care Organizations In Rural Community Settings Of Pakistan Using Health Information Technology (Hit) - A Protocol, Saleema A. Gulzar, Alishah Aziz Gulzar, Zahid Ali Faheem, Ayesha Arif, Aamir Sarfaraz

Journal of Asian Midwives (JAM)

Pakistan is a developing country, with 65% of the population residing in rural areas. The rural population is considered vulnerable mainly due to several factors, including poverty. Climate change and the area's topography limit their access to basic human needs such as basic healthcare, affecting their quality of life. Most people lack basic information about the location and availability of healthcare facilities, including hospitals, diagnostic centres, pharmacies, and general clinics. Hence, the rural healthcare system lacks primary care physicians, nurses, midwives and allied health professionals. Inappropriate infrastructure makes it challenging to retain qualified professionals. A non-profit and non-governmental entity aims …

Kolcaba’S Comfort Theory: A Framework For Understanding The Significance Of Skin-To-Skin Care After Childbirth, Aqsa Nizar Ali

Journal of Asian Midwives (JAM)

Despite the WHO recommendations and evidenced-based results of skin-to-skin contact, it is quite an uncommon practice witnessed after childbirth. Compared to research conducted in low and middle-income nations, the majority of the studies conducted in high-income countries revealed greater rates of SSC [11]. Skin-to-skin contact, a nurturing practice, has gained significant recognition as a cornerstone of early infant care. Beyond its physiological benefits, skin-to-skin contact fosters a profound sense of comfort and connection between mother and infant. Kolcaba's theory of comfort, a comprehensive framework for understanding and promoting comfort, provides a valuable lens to explore the multifaceted benefits of skin-to-skin …

Burden Of Vascular Neurological Disorders: A Cross-Sectional Multicenter Study, Shafaq Saleem, Safia Awan, Ibrar Rafiq, Muhammad Hassan Shaikh, Anjum Farooq, Maimoona Siddiqui, Zainab Aslam Saeed Memon, Alam Ibrahim Siddiqui

Pakistan Journal of Neurological Sciences (PJNS)

Background and Objective

Stroke remains a leading cause of morbidity and mortality worldwide, with a particularly high burden in low- and middle-income countries (LMICs) such as Pakistan. Despite its growing prevalence, limited nationwide data exist on vascular diseases, their risk factors, and disability outcomes. The objective of this study was to identify the frequency and age-stratified type of vascular disease incidence among in-patient hospital admissions.

Methods

A retrospective observational study was conducted across 39 neurology centers in Pakistan, spanning both public and private sectors from August 2017 to December 2019. Data on demographics, comorbidities, and stroke type were systematically collected …

Electrographic Significance Of Periodic Discharges And Association With Etiology And Outcome In A Tertiary Care Hospital: A Retrospective Cohort Study, Hina Imtiaz, Zainab Memon, Ayisha Farooq Khan, Dureshahwar Kanwar, Safia Awan

Pakistan Journal of Neurological Sciences (PJNS)

Background and Objective

Periodic discharges on electroencephalograms (EEGs) are rhythmic waveforms that may indicate acute or subacute brain injury. This aim of this study was to determine the frequency distribution of periodic discharge subtypes on EEG and to assess their association with underlying etiologies and clinical outcomes in a tertiary care hospital.

Methods

This retrospective observational cohort study included neurological patients aged ≥18 years admitted to the medical ICU or ward of Aga Khan University Hospital between January 1, 2021, and January 1, 2023, with periodic discharges on EEG. Patients with prior traumatic brain injury were excluded. Data on demographics, …