New Onset Seizures Evolving Into Refractory Status Epilepticus In The Setting Of Covid-19: A Case Report, Mahira Mushtaq, Zuha Amin, Shafaq Saleem, Fowzia Siddiqui

Pakistan Journal of Neurological Sciences (PJNS)

The novel Coronavirus disease (COVID-19) has been shown to involve the nervous system (both central and peripheral), with or without respiratory involvement in multiple ways. Although not much is known about this disease yet, seizures and status epilepticus which may evolve into refractory status epilepticus have been associated with it along with other manifestations like encephalopathy, neuropathies etc. The mechanism for development of seizures with COVID-19 related disease is not entirely known however it can be the consequence of “cytokine release syndrome” or “cytokine storm” which has been associated with this virus. Patients with COVID-19 infection who develop resistant status …

Pakistan Ischemic Stroke Guidelines, Anjum Farooq, Maria Khan, Ayesha Zafar, Husnain Hashim, Fozan Khan, Abdul Malik, Ayeesha Kamran Kamal Aga Khan University, Karachi, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Stroke is the second leading cause of death and disability. Mortality related to stroke is very high in low- and middle-income countries. Stroke imposes a great socioeconomical burden in Pakistan. It is important to take important steps for prevention and proper management of stroke in country. Purpose of developing stroke guidelines is to improve stroke care in Pakistan. Guidelines are designed to help neurologists and general practitioners for treating stroke. American stroke guidelines, NICE guidelines, Canadian guidelines and multiple important articles including those emphasizing stroke care in low- and middle-income countries were studied, and these current guidelines were designed in …

Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

No abstract provided.

Dalbavancin Use At A Health System Network In Compliance With A Standard Plan Of Treatment For Infective Endocarditis And Osteomyelitis, Nicholas Lombardi, Anthoula Kritikos, Jacky Ye, Victor Cohen

Doctoral External Publications

Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and soft tissue infections caused by gram-positive microorganisms.

Used off-label in the management of infective endocarditis in IV drug users, as well as in osteomyelitis infections.

Extremely long half-life of greater than a week.

Potential cost-effective option for susceptible gram-positive infections and increased patient compliance.

Leading Biologics In Pharmacy Practice: The Role Of Pharmacists, Amerah Elshayeb, Emily Austin, Lipika Chablani

Doctoral External Publications

Evaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of biologics.

Impact Of Order Set Implementation On Institutional Management Of Clostridioides Difficile In Adult Patients, Nicole Henry, Olivia Campbell, Heather Daly, Katelyn Quartuccio, Melanie Lintala

Doctoral External Publications

In February 2022, the University of Rochester Medical Center (URMC) updated their practice guidelines, in accordance with the Infectious Diseases Society of America, to include fidaxomicin as the preferred agent in patients with initial (non-fulminant) or first recurrence of C. difficile infection (CDI).

Health system protocols were updated to include polymerase chain reaction (PCR) testing for patients with suspected CDI followed by confirmation via toxin enzyme immunoassay (EIA).

In the appropriate clinical context, PCR+/EIA+ test confirms active CDI and warrants antibiotic treatment.

PCR+/EIA- test indicates likely colonization and may preclude the need for treatment.

A CDI order set was implemented …

Local Chapters Of Ashp And Apha Partner With The Monroe County Sheriff’S Department To Host A Drug Take-Back Event In The Rochester Community, Mackenzie Bermingham, Michael Currier, Bailey Walker, Laura Witt, Shawn E. Fellows, Angela Nagel

Doctoral External Publications

Objection/Study Goals:

To provide a safe, environmentally responsible way to dispose of unused or expired medications and to raise awareness about the risks of medication misuse in the community.

Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster

All Dissertations

This dissertation investigates the development and optimization of pathology-responsive polymersomes for simultaneous enhanced magnetic resonance imaging (MRI) and enzyme replacement therapy (ERT) in the treatment of GM1 gangliosidosis (GM1). While therapeutic strategies exist for similar, non-neuropathic lysosomal storage disorders, implementation towards GM1 faces significant challenges due to the blood-brain barrier.

Herein, we developed and characterized a range of low molecular weight hyaluronic acid-b-polylactic acid (HA-PLA) polymersomes (PSs) capable of encapsulating therapeutic enzymes in their hydrophilic core. These polymersomes exhibit pathophysiology-triggered responsiveness, degrading in the presence of acidic conditions, which is characteristic of lysosomes, and enzymes such as hexosaminidase A, which …

A Word From The Writing Team (December 2024), Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Publication Spotlight
• Enter the Annual Theresa and Charles Yeo Writing Prize by December 31, 2024
• Sign up for the December 6th Writing Retreat (Online)
• Write that Baby in 9 Weeks
• The OPWPC Canvas Page offers helpful tools

Adverse Childhood Experiences And Early Life Adversity And Their Effects On Chronic Health: A Literature Review, Ella Weatherford

The Eleanor Mann School of Nursing Undergraduate Honors Theses

With more than 439,000 annual U.S. deaths associated with childhood adversity, it is important to understand and prevent exposure to Adverse Childhood Events and Early Life Adversity. The purpose of this literature review is to identify and examine the pathophysiology between adverse childhood experiences (ACE’s) and their negative effects on health across the lifespan. Fifteen peer-reviewed articles that were published in notable journals were analyzed to include in this review. The results of these articles show that Adverse Childhood Experiences and Early Life Adversity can lead to the development of chronic inflammatory conditions across the lifespan. Using Barker Hypothesis and …

The Impact Of Hospital Protocol For Severe Alcohol Use Disorder, Meredith Jones

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Alcohol use disorder remains a prevalent condition within current society. For a smaller, but ever growing population, alcohol use evolves into a severe, addictive disease process. Individuals managing this disorder can suffer from acute withdrawals and further comorbidities causing eventual detriment. Medical institutions attempt to combat withdrawal with varying forms of treatment, utilized to manage symptoms and further issues “as needed.” As this condition becomes increasingly more pervasive within casual society, hospitals’ fragmented attempts to manage this disease process proves to be ineffective for this patient population.

Purpose: The purpose of this systematic review is to analyze current methods …

Constructing A Blueprint For A Professional Development Module On Interventions For Bullying And Self-Advocacy For Nursing Faculty, Glenn Murphy

Boise State University Theses and Dissertations

Bullying remains a persistent issue among nursing faculty. Nursing faculty often claim they do not have the communication skills or the confidence to address bullying behaviors and to advocate for themselves. Instead, they often avoid the perpetrators or accept bullying as part of the nursing education environment. One possible solution involves creating a professional development module for nursing faculty. My Delphi study led to the creation of a blueprint for a professional development module on interventions for bullying and self-advocacy for nursing faculty. Over the three rounds of online questionnaires, an expert panel of nursing faculty suggested content areas, recommended …

Examining The Impact Of Eds And Meds Anchor Institutions On Local Communities: A Mixed Methods Case Study On University Medical Center New Orleans, Samuel P. Firmin

LSU New Orleans Theses and Dissertations

The purpose of this study was to examine how the University Medical Center New Orleans (UMCNO), a major Eds and Meds anchor institution, has contributed to the well-being outcomes of surrounding communities within the New Orleans BioDistrict since its opening in 2015. Eds and Meds institutions often have mixed impacts on their local communities, and little research has focused on their effects in the Deep South, particularly in New Orleans, a region with pronounced socioeconomic disparities. This study aimed to address this research gap by investigating the following question: to what extent does UMCNO's Community Health Needs Assessments align with …

How Does 2 Level Cervical Disc Replacement Compare To Single Level?, Pierce Nunley, Brian Perry, Celeste Abjornson, Ashvin Patel, Faheem Sandhu, Armen Khachatryan, Jad Khalil

Conference Presentation Abstracts

Introduction: Anterior Cervical Discectomy and Fusion (ACDF) is highly successful at a single level with greater than 90% fusion rates and high patient satisfaction. However, multi-level ACDF surgery, though still successful, has diminishing results with increasing levels. With many Investigational Device Exemption (IDE) clinical trials for the treatment of Symptomatic Cervical Disc Disease (SCDD) at a single level and recent IDE clinical trials for two contiguous levels, these trials offer the opportunity to compare clinical outcomes utilizing the same motion sparing technology mechanisms of action (MOA). The hypothesis is that cervical total disc replacement (cTDR) maintains its clinical benefits from …

Analysing Efficiency In The Medical Laboratory Industry Using Stochastic Frontier Analysis, Sinan Ertemel, Levent Kutlu

Economics and Finance Faculty Publications

This paper focuses on the estimation of efficiency within the medical laboratories industry, a sector of vital importance in healthcare due to its provision of essential diagnostic services. To this end, we employ three distinct stochastic frontier models to evaluate the technical efficiency of the medical laboratory industry. Our benchmark model stands out by considering the presence of heterogeneity, leading to robust findings compared to alternative models. The mean efficiency estimate is determined to be 70.6%, while the median efficiency estimate stands at 70.0%. Remarkably, our results highlight that the production technology employed in US medical laboratories demonstrates constant returns …

Students’ Performance And Perceptions Of Mock Trials As A Teaching And Assessment Activity Over Three Years At Two Institutions, Ettie Rosenberg, Shih-Ying H. Hsu, Hoai-An Truong, Reza Taheri

Pharmacy Faculty Articles and Research

Background: This study aimed to evaluate students’ performance and perception of a mock-trial teaching, learning, and assessment activity over three years at two institutions.

Methods: A mock trial (courtroom-style debate) implemented over three years (2017-2019) in a first professional year (P1) course at two institutions offered active learning in literature critique and evaluation, critical thinking, communication, teamwork, professionalism, and self-awareness. Student teams researched, prepared, and debated controversial topics as counsels, witnesses, or jurors for alternate mock trials. Descriptive analyses evaluated judge and juror trial scores and the 2019 Technology Acceptance Model (TAM) survey.

Results: The mock trials involved 319 student …

Opioid Knowledge And Experiences In Nebraska College Students, Natalie Holding

Theses/Capstones/Creative Projects

This study investigated opioid-related knowledge and experiences among 83 Nebraska college students, with an emphasis on awareness, perceived risks, and educational needs regarding opioids and the overdose-reversing drug, naloxone. For participants who have used opioids outside of a doctor’s orders, questions were asked regarding motivations, comorbidities, coping mechanisms, and treatment experiences. Data were collected via an anonymous survey featuring closed- and open-ended questions. Results showed that 41% of participants reported feeling moderately knowledgeable about opioid risks, while 34% felt only slightly knowledgeable. Although 80.7% of participants were aware of naloxone, most were uncertain either about (22.9%) or did not know …

Keeping Mental Health Professionals In Nebraska: How Nebraska Recruits And Retains Working And Prospective Providers, Beckett Allen

Theses/Capstones/Creative Projects

For my capstone effort, I wanted to focus on the recruitment and retention of mental health professionals in Nebraska. Having familiarity with the status of mental healthcare itself in rural Nebraska, my goal was to focus on what is being done to recruit and retain mental healthcare providers in the state.

For this study, interviews were conducted with professionals with experience in examining and addressing provider recruitment and retainment related to mental health.

Federal and state agencies such as the Area Health Education Center (AHEC) and the Behavioral Health Education Center of Nebraska (BHECN) have been formed to address shortages …

Chronic Illness Education 2024: Tackling Childhood Obesity Using The Chronic Care Model, Avan Chu, Bassem Chamma, Katiya Barkho, Ryan Li, Sabrina Pakula, Zoe Raphael

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Educational Resources For Families To Improve Childhood Obesity, Arianna Arcenas, Colton Clymer, Henry Li, Jonathan Albrecht, Kathleen Girdler, Saleh Ahmed

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Addressing Anxiety And Depressive Disorders In The Adult Population, Alexandra Thompson, Andrew Wu, Lauren Kim, Meghana Jalagam, Rahul Bodapati, Tyler White

Patient Education Projects

No abstract provided.

Nicotine Cessation, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Impact Of Pegylated Liposomes On Cytotoxicity Of Tamoxifen And Piperine On Mcf-7 Human Breast Carcinoma Cells, Klaudi K. Vaiphei, A Prabakaran, Singh Snigdha, Satyajit Laxman Murkute, Purusottam Mohapatra, Rakesh Kumar Sahoo, Sanya Batheja, Umesh Gupta, Anu Puri, Upal Roy

Health & Biomedical Sciences Faculty Publications

Tamoxifen (TMF) is an anticancer agent used for managing estrogen receptor-positive breast cancer. It has limited therapeutic efficacy against breast cancer, which could be enhanced by the coadministration of herbal drugs like piperine (PIP). However, the hydrophobic nature of TMF and PIP restricts their therapeutic application. Therefore, the present study focuses on the impact of the anticancer activity of TMF in combination with PIP and after entrapping them into liposomes (TMF-PIP-LPs and TMF-PIP-PEG-LPs). The liposomes were prepared using the thin film hydration method. In addition, the morphology of the prepared liposomes was found spherical after SEM and TEM analyses. Further, …

Creating A Space For Relaxation And Wellbeing At The University Of South Alabama, Mary Wolf

Honors Theses

A program to provide supplementary support for the mental health and wellness of students at a midsize Southern University by providing a centrally located “relaxation space” for students on campus during the last two weeks of the semester is proposed and tested. A central location was found on campus to host the space. The researcher also developed an online survey for students to review the space. The trial was run for two weeks, and participants were able to access the online survey throughout those weeks. The results of the survey were analyzed to better understand the students’ responses to the …

Comparison Of Two Learning Methodologies: Virtual Reality And Osce Simulation, Connor Blackwell, Tabor Mcgee

Doctoral Projects

Anesthesia education has evolved immensely over the past twenty years, and with the new virtual reality (VR) simulations created by SIMVANA, the exponential growth can continue. The anesthesia program at The University of Southern Mississippi (USM) currently utilizes an educational platform known as the Objective Structured Clinical Examination (OSCE) for their students’ clinical curriculum. With the development of technology and education models, the purpose of the doctoral project is to determine if VR simulation can produce more effective learning than the OSCE modules. To determine the effectiveness, pharmacologic lessons for intraoperative hypotension were administered through both platforms and then tested …

Improving Consistency Of Quality-Of-Life-Assessments In Schizophrenia Patients Through Structured Education For Healthcare Providers, Dorothy Stewart

Doctoral Projects

Schizophrenia is a chronic and debilitating mental disorder that significantly impacts patients' quality of life (QoL). Effective management of schizophrenia requires not only symptom control but also a comprehensive assessment of QoL to guide treatment plans. The Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4) is a specialized tool designed to evaluate the unique challenges faced by patients with schizophrenia. However, inconsistencies in the administration and interpretation of the SQLS-R4 by healthcare providers have led to variability in patient care. This doctoral project aimed to address this gap by implementing a structured educational intervention for healthcare providers that focused on …

Utilization Of Quantitative Monitoring To Promptly Detect And Reduce The Occurrence Of Residual Paralysis In The Post-Anesthesia Care Unit, Kathryn Elizabeth Nokes, Erin Moran Travis

Doctoral Projects

Objective: To evaluate the effectiveness of an educational workshop using an Objective Structured Clinical Examination (OSCE) on quantitative neuromuscular monitoring. The goal was to improve the knowledge and skills among certified registered nurse anesthetists (CRNAs) and student registered nurse anesthetists (SRNAs) in identifying residual paralysis. The specific aim was to determine the effectiveness of quantitative monitoring in the Post Anesthesia Care Unit (PACU).

Background: Residual paralysis following the administration of neuromuscular blocking drugs (NMBDs) is a significant postoperative complication. Neuromuscular blocking drugs (NMBD) facilitate airway management and manipulation of surgical fields. Quantitative monitoring can be crucial in early detection and …

Anti-Inflammatory Potential Of Black Cumin Seed Oil And Its Nanoemulsion Formulation Against Lipopolysaccharide-Induced Liver Injury In Mice, Shady Swidan, Hesham Hafez, Rehab Hosni, Hatem Amin

Pharmacy

Original Article

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice

Haffez, Hesham^1,2,✉; Hosni, Rehab³; Swidan, Shady A.⁴; Amin, Hatem K.^1,5

Author Information

¹Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Helwan, 11795, Cairo, Egypt

²Center of Scientific Excellence “Helwan Structural Biology Research”, Helwan University, Helwan, 11795, Cairo, Egypt

³El Sisi Comprehensive Clinic, General Authority for Health Insurance-Giza, Haram, 12556, Giza, Egypt

⁴Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk, 11837, Cairo, …

The Nursing Human Capital Value Model, Olga Yakusheva, Kathryn A. Lee, Marianne Weiss

College of Nursing Faculty Research and Publications

Nursing's economic value is presently framed within the dominant “outcomes-over-cost” value framework. Within this context, organizations employing nurses often use nursing budget reductions as a cost-minimization strategy, with the intent of retaining high quality outcomes. However, persistent issues such as nurse understaffing, burnout, and turnover threaten healthcare systems' capacity to deliver the quality, equitable, affordable patient care that the public requires. In this paper, we propose a new conceptual model and definition of nursing's economic value. The model development is guided by the convergence of three classic economic frameworks: human capital theory, production theory, and value theory. Grounded in these …

Breast Cancer: Her2-Mutant P53 Cooperation And The Cell-Of-Origin Dependent Dynamics, Abie Williams-Villalobo

Dissertations (2016-Present)

Subtype. Specifically, NCP172 and NCP245 tumors grew faster and were predominantly triple- negative than NCP245. RNA sequencing identified many differentially expressed genes (DEGs) between tumor and mammary gland controls. Ingenuity Pathway Analysis (IPA) of the DEGs revealed that pathways like Deubiquitination, Cell Cycle Checkpoints, RHO GTPase cycle, and HIF1α Signaling were associated with aggressive tumor characteristics, with heightened pathway activity in NCP172 likely contributing to greater growth and invasiveness.

This study further examined how different cells-of-origin contribute to breast cancer heterogeneity by inducing mutant p53 in either mammary myoepithelial or luminal cells. Tumors originating from myoepithelial cells (Tk5) exhibited …