Medicine and Health Sciences Commons^™

Cardiovascular Interoceptive Accuracy Correlates With Piezo 1 Mediated Baroreceptor Sensitivity And State Anxiety: Implications For Hypoglycemic Awareness, Jack Summers, Zachary Miklja, Warren Lockette

Medical Student Research Symposium

CARDIOVASCULAR INTEROCEPTIVE ACCURACY CORRELATES WITH PIEZO 1 MEDIATED BARORE- CEPTOR SENSITIVITY AND STATE ANXIETY: IMPLICATIONS FOR HYPOGLYCEMIC AWARENESS. Jack Summers, B.S., Zachary Miklja, M.D., Warren Lockette, M.D., Wayne State University School of Medicine, Detroit, Ml, USA.

Background: There is a brisk, reflex autonomic response to low blood glucose in which surges of catecholamines are released to enhance glycogenolysis, gluconeogenesis, and lipolysis. In addition to providing metabolic substrates, the cardiovascular responses to this surge in norepinephrine and epinephrine include an increase in heart rate and cardiac contractility. How these changes in heart rate and contractility are subjectively sensed and perceived as …

Oromandibular Dystonia: A Dental Perspective On Movement Disorders, Hanyu You, Kristi Soileau Dds, Med, Mshce, Facd, Ficd

New Orleans Dental Association News

Oromandibular Dystonia (OMD) is a rare movement disorder that causes involuntary muscle contractions in the oromandibular region, affecting jaw function, oral hygiene, and dental health. It can lead to tooth wear, TMD, swallowing difficulties, and significant challenges for musicians, requiring a multidisciplinary approach to management.

Noda News April 2025

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

The Impact Of Covid-19 On Nurses' Feelings, Stress, Coping, And Motivation In Palestinian Treatment Centers Of Corona, † Wafaa Menawi, Shatha Mari, Ahmad Adel Hanani

An-Najah University Journal for Research - B (Humanities)

Background: Frontline nurses of COVID-19 found themselves in an unfamiliar new disease work environment, fighting to adapt and control the stress while working at covid-19 centers in Palestine. Aim: To investigate the impact of COVID-19 on nurses' feelings, stress, coping, and motivation in COVID-19 Palestinian treatment Centers. Method: A descriptive cross-sectional design was conducted between Mid of July to the end of October 2021 by recruiting a purposive sample of 390 nurses who worked at the Ministry of Health during COVID-19 pandemic treatment centers. The nurses filled out the COVID-19 Health Personnel Questionnaire with Cronbach's Alpha > 0.9. Results: Palestinian frontline …

Workplace Isolation And Loneliness In School-Based Occupational Therapy Practitioners: A Cross-Sectional Study, Megan Ziff Otd, Otr/L, Amy Carroll Otd, Otr/L, Catherine V. Piersol Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Introduction

• Increasing “epidemic” of social isolation and loneliness in the United States
• The workplace is one locale that can provide social connection¹
• School-based occupational therapy practitioners (SBOTPs) report feeling isolated in the workplace²
• Lack of time can constrain development of collaborative relationships³
• Contractors in particular report feeling on the outskirts of school team communication⁴
• No prior study specific to SBOTP’s workplace isolation and loneliness

Purpose: Describe workplace isolation and workplace loneliness in SBOTPs; investigate their relationship to employment type, and indirect time.

Hypothesis 1: A weak-to-moderate positive relationship between workplace isolation and workplace loneliness in SBOTPs …

The Impact Of Childhood Sexual Abuse On Resilience And Empathy In Adulthood: Exploring Psychological Outcomes And Interrelationships Among Adult Survivors, Helen Dao

NYMC Student Theses and Dissertations

Background: Childhood sexual abuse (CSA) is a traumatic experience that can have lasting psychological impacts on its survivors. Resilience and empathy are crucial for the recovery and social functioning of CSA survivors. However, the relationship between CSA and these constructs remains complex and not fully understood. Purpose: This study aimed to determine whether significant differences exist between individuals who have experienced CSA and those who have not. Additionally, the study also investigated the relationship between empathy and resilience. Methodology: A cross-sectional study was conducted with 36 adult participants, including CSA survivors and non-CSA participants. The Connor-Davidson Resilience Scale was used …

Culturally Appropriate Mental Health Awareness To Reduce Mental Health Stigmatization And Improve Quality Of Life Among People Of African Descent., Nicoline Frinwie

Walden Dissertations and Doctoral Studies

No abstract provided.

Building Empathy Through Storytelling: A Living Library Program Focused On Women’S Health, Jess King, Belinda Boelter, Catherine Medici-Thiemann

Posters and Presentations: Leon S. McGoogan Health Sciences Library

An academic health sciences library hosted a grant-funded living library program titled “Bringing Stories of Women’s Health to the Forefront.” With a campus that is increasingly focused on incorporating the humanities into medical education, the library added to this momentum by offering a program which encouraged empathy through the art of storytelling. The program was delivered via three routes: an in-person event for the city’s metro community, a virtual event for the university community and their clinical partners, and oral interview video recordings that are hosted on the library website. In order to host a successful event that met the …

Enhancing State-Of-The-Art Motor Imagery Classification With Reinforcement Learning, Anton Shepelev

USF Tampa Graduate Theses and Dissertations

One of the key obstacles to the rapid adoption of non-invasive Brain-Computer Interfaces (BCIs) for Motor Imagery (MI) is the low signal-to-noise ratio, and the substantial data requirements which can be mentally taxing for users. EEGNet, a compact Convolutional Neural Network (CNN), has long been considered the state-of-the-art (SOTA) for MI classification, demonstrating strong performance even with limited data. However, recent studies advocate for integrating Deep Reinforcement Learning (RL) to further enhance classification accuracy by dynamically optimizing feature extraction and decision-making processes. Despite this potential, practical implementations remain scarce due to challenges in stabilizing RL training and adapting it to …

A Long Non-Coding Erna Forms R-Loops To Shape Emotional Experience-Induced Behavioral Adaptations, Rose Marie Akiki

MUSC Theses and Dissertations

Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4. We discovered that a conserved, long non-coding enhancer RNA (lnc-eRNA) transcribed from an activity-sensitive enhancer produces DNA-RNA hybrid R-loop structures that support 3D chromatin-looping of the enhancer and proximal promoter and stimulus-induced, rapid Npas4 gene induction. We also show that this Npas4 lnceRNA and its R-loops are required for the development of behavioral adaptations produced by chronic psychosocial stress or cocaine exposure, …

Comparison Of Treatments For Lumbar Disc Herniations & Long-Term Pain Relief, Becca Pollack

D.U.Quark

A lumbar disc herniation (LDH) occurs when the intervertebral disc pushes out from the disc space and irritates the surrounding nerves. LDHs are typically diagnosed via MRI scan, and the most common symptoms are low back pain and shooting leg pain, along with leg weakness/numbness. Although many different treatments are available to treat LDHs, few papers have compared the efficacy of treatment beyond 12 months. This review evaluates the differences between popular LDH treatments, like epidural steroid injections and microdiscectomies, at reducing leg and back pain, as well as comparing newer treatments’ efficacy at treating pain. Research comparing treatments should …

Addressing Hiv And Substance Use Health Disparities Among Racial/Ethnic Minority Individuals, Jamie V. Saunt, David L. Hussey

Faculty Scholarship

Purpose of Review: Advances in HIV testing, prevention, and treatment, alongside increased awareness and harm reduction efforts for substance use disorder (SUD) have improved care and treatment access over the past decade. However, racial and ethnic minorities with SUD and HIV or at risk for HIV still face disproportionately high health disparities. Understanding and addressing the reasons behind these disparities is crucial. Recent Findings: Structural and systemic barriers continue to negatively impact minoritized communities, due to lack of access to care, mistrust, and feelings of ostracization. Disconnected systems for HIV and SUD treatment complicate combined care. Delays in HIV diagnosis …

Aprn Transition To Primary Care Practice Program: A Quality Improvement Project, Melissa R. Baker

Graduate Theses, Dissertations, and Capstones

Transitioning to independent practice presents challenges for advanced practice registered nurses (APRNs) new to primary care. This quality improvement project addressed gaps in training and support through a structured Transition to Primary Care Practice (TTPCP) program across multiple primary care clinics in the southeastern United States. Over 12 months, the program provided weekly didactic sessions, monthly specialty rotations, and bi-weekly feedback. Guided by the Plan-Do-Study-Act framework, the initiative tracked structure, process, and outcome measures. Among 20 participants, attendance and schedule ramp-up reached 100%. Knowledge scores improved by 44%, and self-assessments increased by 23%. All assessed participants were rated Proficient or …

The Development Of Consensus Recommendation To Improve Practice Harmonization For Sickle Cell Disease Through The National Alliance Of Sickle Cell Centers, Julie Kanter, Melissa Frei-Jones, Deepa Manwani, Marsha Treadwell, Mohan Madisetti, Robin E. Miller, Seethal A. Jacob, Sana Saif-Ur-Rehman, Andrew O'Brien, Sophie Lanzkron

Cardeza Foundation for Hematologic Research

Introduction SCD remains the most common inherited blood disorder. Due to a lack of strong evidence, the management of sickle cell is often anecdotal, local to individual centers, states, and countries. Even in areas of practice with high-level data to improve practice, implementation has not been consistent. The historical lack of an agreed-upon national registry has compounded this problem and resulted in a lack of comparative effectiveness data to identify areas of deficiency and improve practice. These barriers have resulted in centers developing local policies and procedures, often with limited communication with other centers, resulting in disparate and inconsistent care. …

Findings From A Qualitative Analysis: Social Media Influencers Of Color As Trusted Messengers Of Hpv Vaccination Messages, Amelia Burke-Garcia, Erin Cutroneo, Dasha Afanaseva, Kayla Madden, Angela Sustaita-Ruiz, Preethi Selvan, Estefany Rivera Sanchez, Amy Leader

Department of Medical Oncology Faculty Papers

BACKGROUND: Despite HPV vaccination reducing the prevalence of cervical cancer by 90%, vaccination rates remain lower among communities of color due to vaccine hesitancy and mistrust in traditional public health messengers. The emergence of social media influencers, a newer kind of messenger, presents a unique opportunity to share immunization messages in new ways with a variety of communities. This paper reviews the qualitative findings from a study aimed at assessing influencers' perceptions of and approaches to sharing messaging about the HPV vaccine.

METHODS: Guided by several theories (Theory of Planned Behavior, Narrative Theory, and Opinion Leader Theory), the study team …

Staff Education To Improve Hand Hygiene Among Inpatient Behavioral Health Staff., Folashade Abosede Fadairo

Walden Dissertations and Doctoral Studies

In this staff education project, I addressed the critical need to improve hand hygiene compliance among healthcare workers in behavioral health settings. Poor adherence to hand hygiene protocols is directly linked to increased healthcare-associated infections (HAIs), patient morbidity, and higher healthcare costs in behavioral health environments. The practice-focused question was: How does a hand hygiene intervention program, grounded in the theoretical domains framework, impact hand hygiene compliance among behavioral healthcare workers in inpatient psychiatric units? The purpose of the project was to evaluate the effect of a hand hygiene intervention program on compliance rates among behavioral healthcare workers in inpatient …

Social Support And Treatment Outcomes Among Multi-Drug Resistant Tuberculosis And Persons Living With Hiv In Nigeria, Abiodun Olusegun Hassan

Walden Dissertations and Doctoral Studies

An estimated 40% of people with tuberculosis (TB) are missed due to underdiagnosis, and among those previously treated TB cases, about a quarter develop drug-resistant TB in Nigeria. The emergence of multi-drug-resistant TB (MDR-TB) is stalling the effort towards TB’s control and eradication. Few studies have examined the impact of the psychosocial effect and support systems for TB, particularly for MDR-TB. In this quantitative, cross-sectional study, the predictive relationship between social support given to MDR-TB patients and their treatment outcomes was examined using secondary data of 594 MDR-TB cases enrolled between January 2018 and December 2021. The theoretical framework for …

Alpha-Synuclein Seed Amplification Assays: Data Sharing, Standardization Needed For Clinical Use, Hilal A Lashuel, D James Surmeier, Tanya Simuni, Kalpana Merchant, Byron Caughey, Claudio Soto, Mohamed-Bilal Fares, Roland G Heym, Ronald Melki

Faculty, Staff and Student Publications

Alpha-synuclein seed amplification assays can improve neurodegenerative disease diagnosis and care, but widespread use depends on a framework that standardizes protocols and encourages data sharing.

Disability-Related Diversity In Occupational Therapy: A Scoping Review, Molly Whitlow, Allison Singh, Johana Cedillo, Brady A. Harrison, Sydney Wondra

Posters and Presentations: Occupational Therapy

No abstract provided.

A Phase Ii Trial Of Sitravatinib + Nivolumab After Progression On Immune Checkpoint Inhibitor In Patients With Metastatic Clear Cell Rcc, Andrew W Hahn, Nabil Adra, Ulka Vaishampayan, Lianchun Xiao, Nazli Dizman, Ying Yuan, Sagar S Mukhida, Matthew T Campbell, Jianjun Gao, Amado J Zurita, Eric Jonasch, Nizar M Tannir, Amishi Y Shah, Pavlos Msaouel

Faculty, Staff and Student Publications

Background: Sitravatinib, an oral multi-kinase inhibitor targeting VEGFR, TAM, and MET, has been shown to resensitize the tumor microenvironment to immune checkpoint inhibitors (ICI) by reducing immune-suppressive myeloid cells in metastatic clear cell RCC (ccRCC). ICI is the standard first-line (1L) treatment of metastatic ccRCC, and there is unmet need for improved treatment outcomes after progression on ICI. We hypothesized that sitravatinib plus nivolumab would revert an immunosuppressive tumor microenvironment (TME) to improve clinical outcomes.

Methods: In this investigator-initiated, phase II, multicenter trial (NCT04904302), patients with progressive metastatic ccRCC after 1-2 lines of treatment were enrolled into 3 …

Year 1 Of Medicare's Accountable Care Organization Realizing Equity, Access, And Community Health Model, Gmerice Hammond, Sunny Lin, Sukruth A Shashikumar, R J Waken, Fengxian Wang, Khavya Avula, Vi-Anh Hoang, Kenton J Johnston, Karen Joynt Maddox

2020-Current year OA Pubs

IMPORTANCE: The US Centers for Medicare & Medicaid Services launched the Accountable Care Organization (ACO) Realizing Equity, Access, and Community Health (REACH) payment model in January 2023. In contrast to prior ACO initiatives, such as the Medicare Shared Savings Program (MSSP), ACO REACH includes equity-focused measures and payment adjustments, including an equity plan and financial risk adjustment for ACOs with higher proportions of underserved beneficiaries. However, it is unknown whether these changes have incented participation from organizations that serve beneficiaries from marginalized communities.

OBJECTIVE: To compare characteristics between participants in ACO REACH with those in MSSP and the broader pool …

Case Report: Myeloid Neoplasms With The T(3;12)(Q26.2;P13.1)/ Mecom-Etv6 Translocation: Report Of Two New Cases And Review Of The Literature, Soumya Mikkilineni, Juan Pablo Pineda-Reyes, Lindsay Wilde, Andres Ferber, Zi-Xuan Wang, Stephen Peiper, Guldeep Uppal, Md, Jerald Gong, Jinglan Liu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The MECOM (MDS1 and EVI1 complex locus) gene, located at 3q26.2, encodes an oncogenic transcription factor implicated in multiple signaling pathways. Rearrangements involving MECOM/3q26.2, including inversions, translocations, insertions and cryptic chromosomal changes, are observed in myeloid neoplasms and are associated with high-risk disease features and poor clinical outcomes. The translocation t(3;12)(q26.2;p13.1) is a rare genetic event, resulting in a fusion of the MECOM gene at 3q26.2 with the ETV6 gene at 12p13.1. To date, only 78 cases of hematologic neoplasms harboring t(3;12) have been reported in the English literature, primarily as case reports or case series. T(3;12) has …

Ketorolac And Dexamethasone Injection Comparison On Postoperative-Pain In Impacted Mandibular Third Molars Surgery In Pterygomandibular Space: A Randomized Clinical Trial, E. Farokh-Gisour, S. Hajmohamadi, M. Shokrizadeh, S.Y. Shahrbabaki, Homa Kamyabi

School of Public Health Faculty Publications

Objective: To compare the effects of ketorolac and dexamethasone on postoperative pain in patients who underwent impacted mandibular third molars surgery. Material and Methods: A double-anonymized clinical trial study involving 60 patients with impacted third molars. The samples were randomly divided into two groups by block randomization method: DG: Dexamethasone (8 mg) and KG: Ketorolac (30 mg). The severity of pain was assessed using the visual analog scale and Wong-Baker Faces Pain Rating Scale immediately and during the first to seventh days after the surgery. Results: Among the participants, 65% were female, and the mean age was 40.8 years. The …

K-Mer Analysis Of Long-Read Alignment Pileups For Structural Variant Genotyping, Adam C English, Fabio Cunial, Ginger A Metcalf, Richard A Gibbs, Fritz J Sedlazeck

Faculty, Staff and Students Publications

Accurately genotyping structural variant (SV) alleles is crucial to genomics research. We present a novel method (kanpig) for genotyping SVs that leverages variant graphs and k-mer vectors to rapidly generate accurate SV genotypes. Benchmarking against the latest SV datasets shows kanpig achieves a single-sample genotyping concordance of 82.1%, significantly outperforming existing tools, which average 66.3%. We explore kanpig's use for multi-sample projects by testing on 47 genetically diverse samples and find kanpig accurately genotypes complex loci (e.g. SVs neighboring other SVs), and produces higher genotyping concordance than other tools. Kanpig requires only 43 seconds to process a single sample's 20x …

Bright And Photostable Yellow Fluorescent Proteins For Extended Imaging, Jihwan Lee, Shujuan Lai, Shuyuan Yang, Shiqun Zhao, Francisco A Blanco, Anne C Lyons, Raquel Merino-Urteaga, John F Ahrens, Nathan A Nguyen, Haixin Liu, Zhuohe Liu, Gerard G Lambert, Nathan C Shaner, Liangyi Chen, Kimberley F Tolias, Jin Zhang, Taekjip Ha, François St-Pierre

Faculty, Staff and Students Publications

Fluorescent proteins are indispensable molecular tools for visualizing biological structures and processes, but their limited photostability restricts the duration of dynamic imaging experiments. Yellow fluorescent proteins (YFPs), in particular, photobleach rapidly. Here, we introduce mGold2s and mGold2t, YFPs with up to 25-fold greater photostability than mVenus and mCitrine, two commonly used YFPs, while maintaining comparable brightness. These variants were identified using a high-throughput pooled single-cell platform, simultaneously screening for high brightness and photostability. Compared with our previous benchmark, mGold, the mGold2 variants display a ~4-fold increase in photostability without sacrificing brightness. mGold2s and mGold2t extend imaging durations across diverse modalities, …

Normalized And Directional Interplay Scoring For The Interrogation Of Proteoform Data, Karl F Poncha, Alyssa T Paparella, Nicolas L Young

Faculty, Staff and Students Publications

Histone proteoforms, often presenting multiple co-occurring post-translational modifications (PTMs), are central to chromatin regulation and gene expression. A proteoform is a specific form of a protein that includes variations arising from genetic changes, alternative RNA splicing, proteolytic processing, and PTMs. Genome-indexed histone proteoforms define the histone code, influencing cellular phenotype by dictating DNA interacting partners. Understanding the dynamics of histone proteoforms is essential for elucidating chromatin-based regulatory mechanisms. Advances in middle-down and top-down proteomics enable accurate identification and quantitation of thousands of proteoforms in a single run. However, the resulting data complexity presents significant challenges for analysis and visualization. Here, …

Responsible Sharing Of Qualitative Research Data: Insights From A Pioneering Project In The United States, Heidi A. Walsh, Meredith V. Parsons, Jessica Mozersky, Aditi Gupta, Albert M. Lai, Annie B. Friedrich, James M. Dubois

2020-Current year OA Pubs

No abstract provided.

Does A Waiting Room Increase Same-Day Treatment For Sexually Transmitted Infections Among Pregnant Women? A Quality Improvement Study At South African Primary Healthcare Facilities, Ranjana M. Gigi, Mandisa M. Mdingi, Lukas Bütikofer, Chibuzor M. Babalola, Jeffrey D. Klausner, Andrew Medina-Marino, Christina A. Muzny, Christopher M. Taylor, Janneke H. Van De Wijgert, Remco P. Peters, Nicola Low

School of Medicine Faculty Publications

BACKGROUND: Same-day testing and treatment of curable sexually transmitted infections (STI) is a strategy to reduce infection duration and onward transmission. South African primary healthcare facilities often lack sufficient waiting spaces. This study aimed to assess the proportion of, and factors influencing, pregnant women waiting for on-site STI test results before and after the installation of clinic-based waiting rooms. METHODS: We conducted an observational quality improvement study at 5 public primary healthcare facilities in South Africa from March 2021 to May 2023. The intervention was the installation of a waiting room in two clinics. Three clinics were used as comparators: …

A Hypoxia Research-Driven Path Led To Identifying Neuroprotection Mediators: An Interview With Dr. Nicolas G. Bazan, Nicolas G. Bazan

School of Medicine Faculty Publications

No abstract provided.

Effects Of Treatment With Af38469 On Localization Of Lysosomal Proteins In Batten Disease In Vitro Models, Ainslie Robinson, Mitchell Rechtzigel, Hannah Leppert, Joelle Anderson, Jon Brudvig, Jill Weimer

Celebration of Research

Batten disease is a rare, pediatric, neurological disorder that is the result of a mutation in one of 13 CLN genes. Batten disease has an incidence rate of 1 out of 100,000 births worldwide with CLN3 being the most common form. Being a genetic disorder, gene therapy is an ideal treatment approach for Batten disease. Diagnosis of disease, however, typically does not occur until disease has progressed, when the ideal therapeutic window for gene therapy has already passed. Additionally, the durability of viral-delivered gene therapy over time is poorly understood. AF38469, a small molecule inhibitor of sortilin, was developed for …