Medicine and Health Sciences Commons^™

The Most Current And Effective Pharmaceutical Treatment Options For Chronic Migraines, Sophia Riley, Sierra Wright, Hannah Hall, Jill Van Otterloo

Celebration of Research

Chronic migraine (CM) is a debilitating condition that affects a significant portion of the population. Treatment for CM is a current area of research with new medications being developed. One of the latest mechanisms of action for treatment is targeting the calcitonin gene-related peptides. Two classes of drugs block that pathway, Anti-CGRP monoclonal antibodies and CGRP receptor antagonists. Another therapy that has been utilized recently for the preventative treatment of CM Onatabotulliniumtoxin A (Botox).

Continued Care In Female Patients With Tetralogy Of Fallot Into Adulthood And Pregnancy, Taylar Boerema, Mayle Owen, Anna Topp, Jolene Harris

Celebration of Research

Tetralogy of Fallot (TOF) is a congenital heart disease with four distinct characteristics: pulmonary valve stenosis, overriding aorta, right ventricular hypertrophy (RVH), and ventral septal defect (VSD). Surgical correction is now an option with 98% survival rate. Patients with repaired TOF (rTOF) often reach adulthood and can transition out of pediatric care. Unfortunately, providers trained to care for adults with congenital heart defects are not readily available. This has caused a lapse in care for many individuals with TOF. Additionally, providers trained to care for patients with congenital heart defects are needed to monitor patients with pre-pregnancy counseling and throughout …

Cardiovascular Effects Of Glp-1ra In Patients With Type 2 Diabetes, Courtney Legner, Gabriel Legner, Sandra Muyskens

Celebration of Research

The rising prevalence of type 2 diabetes mellitus (T2DM) in the US has led to an increased risk of cardiovascular disease (CVD) among affected individuals. GLP-1RA have been used since 2005 to help manage diabetic patients by controlling glucose levels, weight loss, and in further research, reducing cardiovascular disease. This review examines the cardiovascular effects of GLP-1RA highlighting key clinical trials including the LEADER, SUSTAIN, PIONEER 6, REWIND, and AMPLITUDE-O trials looking at liraglutide, semaglutide oral and subcutaneous, dulaglutide, and efpeglenatide. These studies found a significant decrease in major adverse cardiac events (MACE) in the drug groups when compared to …

Evaluation Of Aerobic Exercise And Neck-Targeted Exercise In Reducing Migraine Frequency And Symptoms, Carissa Cunningham, Carly Christensen, Rick Loutsch

Celebration of Research

Migraine is a prevalent headache disorder that significantly impacts quality of life for sufferers, yet there continues to be no clear treatment to reduce the burden for many. Exercise is one proposed intervention that has been shown to reduce the frequency and symptoms of migraine. Both aerobic exercise and specific muscle-focused exercises have been evaluated in improving the quality of life for migraine sufferers with supporting evidence for efficacy. While more research is needed, exercise can be a beneficial method for patients wanting to avoid pharmaceutical intervention and reduce their migraine symptoms in a more holistic manner.

Implementation Of Virtual Nursing, Kennedy Van Beek, Lydia Zink, Gabrielle Johnson, Brieannah Brands, Madison Naig, Pam Hulstein

Celebration of Research

A literature review was conducted between the months of August 2024 and November 2024 to explore how virtual nursing can improve quality of care. Ten articles focusing on the implementation of virtual nursing were reviewed and analyzed. The purpose of this review is to assist Spencer Hospital in their goals of decreasing the number of staff onsite and offloading the tasks of medication checks, admissions, and documentation to virtual nurses. In the literature review below, we compile resources to explore how virtual nursing influences workflow, patient safety, finances, and satisfaction of both patients and providers. Although many benefits regarding the …

Evaluating The Efficacy Of Focused Ultrasound In Neurological Disorders And Malignancy, Kennedi Henke, Ryan Takens, Heidi Smith, Andrea Crew

Celebration of Research

Focused Ultrasound (FUS) is an emerging therapeutic strategy for neurological diseases, including Parkinson’s disease, Alzheimer’s disease, and brain tumors. Despite advancements in conventional treatments, challenges such as invasive procedures, limited drug delivery across the blood-brain barrier (BBB), and declining long-term efficacy necessitate novel approaches. FUS offers non-invasive neuroablation, BBB modulation, and enhanced drug delivery, positioning it as a promising alternative to traditional therapies. This review examines the clinical evidence on FUS’s role in tumor reduction, tremor management, and amyloid plaque reduction, highlighting its benefits, challenges, and future potential in neurological disease treatment.

Continuous Glucose Monitoring Vs Fingerstick Monitoring In Pediatric Type I Diabetes, Lucia Latawiec, Hannah Schubrych, Carmen Almendarez, Leslee Graff

Celebration of Research

Type 1 diabetes is rising in the adolescent population, and with that is a rise in technological advances, including continuous glucose monitoring (CGM). CGM and finger-stick testing provide accurate measurements of blood glucose levels, aiding in control of both hyperglycemic and hypoglycemic events. CGM provides multiple benefits over finger-stick testing, including reduced number of skin pricks, easier access sites, and various others. CGM also presents with several complications, including high costs and skin irritation. The goal of increased CGM use and awareness is to decrease long-term complications of type I diabetes in the adolescent population, including cognitive function decline, retinopathy, …

Angiotensin Converting Enzyme Inhibitor Induced Angioedema (Acei-Ae): Emergency Department Treatments, Logan Held, Marcus Blankenspoor, Kristine Her, Jolene Harris

Celebration of Research

Angiotensin Converting Enzyme Inhibitor Induced Angioedema (ACEI-AE) is the acute swelling of the upper airway in patients who are currently or were formerly taking Angiotensin Converting Enzyme Inhibitors (ACEIs) for control of primary hypertension. Though emergency department presenting signs and symptoms have overlap with angioedema associated with anaphylaxis, there are key differences, including the absence of urticaria or hypotension and history of ACEI use, that can guide clinicians in identifying the underlying cause of the angioedema and initiate appropriate treatment. Due to its differing pathophysiology, ACEI-AE must be treated uniquely with Tranexamic Acid (TXA) and Fresh Frozen Plasma (FFP) to …

Screening Resources And Interventions For Postpartum Depression, Gianna Escalera, Emma Haley, Nicholas Helderop, Stella Umphreys, Samantha Vermeer, Pam Hulstein

Celebration of Research

A literature review was conducted between the months of August 2024-November 2024 to explore screening, diagnosis and intervention for patients experiencing PPD. 10 articles focusing on these three topics were reviewed. The purpose of this project was to examine current research regarding PPD screening, diagnosis, and intervention and to suggest evidence-based modifications to the current practice at Sioux Center Health. The following literature review provides several alterations to current practice regarding time of screening, education of providers, and interventions offered, to produce best outcomes for PPD patients.

Keywords: Postpartum Depression, Postpartum, Perinatal, Prenatal, Edinburgh Postnatal Depression Scale

The Efficacy And Safety Profile Of Adalimumab And Secukinumab In Treating Hidradenitis Suppurativa, Abby Witte, Ella Eibensteiner, Madelyn Wilkinson, Andrea Crew

Celebration of Research

Hidradenitis suppurativa is a chronic inflammatory disorder of the follicular epithelium in the axilla, groin, peritoneum, and intertriginous areas that presents with painful nodules and abscesses. Due to the poorly understood etiology of the disorder, there are various different treatment options targeting proposed mechanisms of actions which results in a lot of trial and error to find the appropriate treatment plan. Clinicians must consider the whole patient while understanding the efficacy of the medication, possible adverse reactions, and patient compliance when creating a treatment plan, especially with the use of systematic biologics. This review aims to compare two currently FDA-approved …

Delaying The Newborn Bath For Twenty-Four Hours, Ashley Hellewell, Grace Radcliffe, Kendyl Ruschy, Breelle Van Zee, Pam Hulstein

Celebration of Research

Delaying newborn bathing beyond 24 hours aligns with the WHO guidelines on newborn care, and is beneficial to neonatal outcomes:

• Potential to improve several key outcomes of extrauterine stabilization and breastfeeding.
• Reduces neonatal hypothermia and hypoglycemia.
• Increases prevalence of breastfeeding rates.

Studies reported mixed results regarding the significance of these outcomes; however, data favors the practice of delayed infant bathing. Further research is warranted to address limitations and gaps in research.

By implementing delayed newborn bathing, healthcare providers have the potential to improve the overall health outcomes of the infant and support wellbeing.

Hypoglycemic Predictive Modeling Tool, Zoe Bruflat, Pam Hulstein

Celebration of Research

Introduction: This evidence-based practice (EBP) project aims to improve patient safety and outcomes through the implementation of a predictive modeling tool (XGBoost) to predict and prevent hypoglycemic events in hospitalized adults at Sanford Health. Hypoglycemia continues to be a major safety concern, and early prediction can prevent complications

Methods: The project involved a literature review of articles to identify and recommend a hypoglycemic predictive modeling tool for Sanford Health. Included articles were published between 2019 and 2024 and selected through keywords like inpatients, hypoglycemia, glucose prediction, and predictive modeling. Searches across databases, including PubMed, JAMA, JIML, …

Preseason Mileage Influences The In-Season Training Effect In Female Cross Country Runners, Abby Ervin, Dean Calsbeek

Celebration of Research

Purpose: The purpose of this study was to analyze how preseason mileage influences the in-season training effect on maximal oxygen uptake (VO_2max) and lactate threshold (LT) in trained NAIA runners. Methods: Eight female distance runners (age 21.2 0.5 y) ran preseason mileage prior to the start of the cross country season. Subjects completed a graded treadmill test to determine VO_2max and VO₂ at OBLA (VO₂ OBLA) at the beginning and end of a 9 week competitive season. Results: Postseason testing revealed VO_2max significantly improved (p=0.009), while no significant improvement occurred in VO₂ OBLA …

Point Of Care Ultrasound To Manage Fluid Resuscitation In Septic Shock​, Micah Vander Wiel, Ian Wiersma, Jaclyn Freese

Celebration of Research

Sepsis is a health complication causing immune dysregulation and ultimately end-organ damage, with millions of cases and deaths reported annually.1,2 The financial burden of sepsis is substantial and results in hospitalization costs in the United States exceeding $52 billion per year.3 Early diagnosis and effective management strategies are necessary to reduce morbidity and mortality following sepsis and septic shock.

This paper examines the use of Point-of-Care Ultrasound (POCUS), specifically Inferior Vena Cava (IVC) collapsibility and how it may be able to guide fluid resuscitation management for patients with sepsis.4 While POCUS has not consistently demonstrated a significant decrease in rates …

Assessing The Gaps Between Ethnic Populations: A Comparison Of Lipid-Lowering Interventions ​, Chasen Hershman, Gavin Lamott, Chester Dejong Md

Celebration of Research

Pharmacological and lifestyle interventions have been a proven strategy for lowering the cardiovascular risk in all populations. Despite this, certain ethnic populations have a greater ASCVD risk due to either high LDL levels or other factors. The goal of this review is to analyze variables (specifically LDL) that contribute to certain ethnic populations demonstrating a greater risk of CVD as well as interventions that can improve outcomes. Treatment of hyperlipidemia requires a multifactorial approach which is tailored to the individual patients’ needs. Statins continue to be first-line pharmacological therapy for the treatment of lowering LDL. When combining a healthy diet …

Mobile Health Interventions In Diabetic Care In Times Of Environmental Crisis, Sarah Weisbrod, Makenzie Snyder, Maren Nerem, Katrina Hopkins, Pam Hulstein

Celebration of Research

A literature review was conducted between the months of August 2024 - November 2024 to explore the impact that the environmental effects of flooding have on those with diabetes mellitus (DM) and how the implementation of multiple forms of mobile health (mHealth) can aid in recovery and preparedness. Ten articles focusing on the various impacts that flooding and other natural disasters have on diabetic individuals, as well as the positive health outcomes tied to mobile applications and SMS messaging systems were reviewed. The purpose of this review was to examine current research regarding the treatment, education, and preparedness of diabetic …

Utilizing Buprenorphine In Patients With Opioid Use Disorder, Emma Roush, Dani Prusha, Emily Smith, Jaclyn Freese

Celebration of Research

Buprenorphine, a partial mu-opioid agonist, is a critical medication in treating opioid use disorder (OUD) and chronic pain. It was initially developed in the 1960s, then approved for pain management in the 1980s. However, over the past two decades, buprenorphine’s use has expanded to OUD treatment, demonstrating improved patient outcomes, enhanced treatment retention, and reduced opioid use. Its longer half-life allows for less frequent dosing and greater adherence compared to full agonists. Buprenorphine also has a more favorable safety profile compared to methadone, which results in lower risks of respiratory depression and overdose.

Despite its efficacy, buprenorphine remains underused due …

Subcutaneous Infusions For Hydration And Nutrition, Bryn Hoekman, Kelsie Dulmes, Laci Van Hauen, Megan Vankalsbeek, Mikayla Johnson, Pam Hulstein

Celebration of Research

Subcutaneous (SC) infusions deliver fluids or medications into the body's fatty tissue using small needles. They are cost-effective, easy to use, comfortable, and carry a low risk of serious complications like infections. In hospital settings, IV access can be challenging, and oral fluid intake may be insufficient for proper hydration. Spencer Hospital was interested in the potential benefits of SC infusions and what population would benefit most. The purpose of this project was to examine SC infusions as an alternative for hydration when IV access is unavailable, focusing on pediatric, geriatric, and palliative population. It compared Hydration, nutrition status, and …

Factors Influencing Emergency Department Length Of Stay In Pediatric Burn Patients, Nishant S. Kumar Bs, Katherine Oag Msn, Rn, Accns-P, Ccrn, Lisa Vitale Bsn, Rn, Cpn, Tcrn, Mariah Malaniak Msn, Rn, Cpn, Cbrn, Justin Klein Md, Elika Ridelman Phd, Christina Shanti Md

Medical Student Research Symposium

Introduction: Globally, the demand for pediatric emergency department (ED) visits has increased, leading to extended lengths of stay (LOS) in the ED. Prolonged ED length of stay (LOS) can delay definitive care and impact outcomes. This study investigates factors contributing to extended ED LOS in an urban, ABA-verified pediatric burn center.

Methods: We conducted a retrospective chart review of pediatric burn patients who presented between March 1, 2023, and March 1, 2024, with ED stays of ≥4 hours. Data on demographics, clinical presentation, and treatment were analyzed.

Results: Among 300 patients, the average ED LOS was 6 hours and 12 …

Determining The Wound Closure Capabilities Of A Biological Engineered Blood Vessel For Hd Access, Brianna Regan, Alex Dumitru, Mai Lam

Medical Student Research Symposium

End stage renal disease (ESRD) is a prominent chronic condition with dialysis as a primary treatment option. Dialysis necessitates implementation of an access point, with the gold standard being an AV fistula which possesses multiple shortcomings. Alternative access points, namely synthetic grafts, do not allow wound healing characteristics. This work aims to explore how a tissue engineered vascular graft (TEVG) may be able to address these issues by allowing a long-term access point for HD that can close puncture wounds.

The effects of growth factors on our cells were tested preliminarily by means of a scratch assay on plates of …

Safety And Efficacy Of 112 Mg Intranasal Esketamine In Patients With Treatment-Resistant Depression: A Retrospective Observational Study From Outpatient Community Clinics, Kirsten Brinkmeier, Michael Kritzer, Brandon Doan, Cecilia Li, Nicholas Mischel

Medical Student Research Symposium

This retrospective study examined the safety and efficacy of 56, 84, and 112 mg intranasal (IN) esketamine via medical record review of 24 patients with treatment resistant depression (TRD). Doses ranged from 56 mg to 112 mg and were titrated across sessions to maximize individual response while considering tolerability. Treatment response was defined by reduction in average Patient Health Questionnaire-9 (PHQ-9) scores. Tolerability was defined by blood pressures at baseline, 40 minutes after, and 2 hours after drug administration. Patients ranged from 19 to 60 years old (average 38.87), and 15 (62.5%) were female. Patients received an average of 1 …

Evaluating Engagement In Health Care And Substance Use Disorder Services Among People Who Use Drugs, Tiffany Mckenney, Kevin Cobty, Divya Boorle, Julie Gleason-Comstock

Medical Student Research Symposium

An urban community-based organization conducted a study to examine demographics of individuals who use drugs and their approaches to risk reduction. A substantial proportion reported encountering significant barriers to accessing substance use disorder (SUD) services.

In collaboration with a state survey, the community organization recruited a convenience sample of individuals who actively used drugs, examining substance use patterns, healthcare access, and barriers to SUD services. Community health workers facilitated outreach efforts, focusing on harm reduction engagement, and healthcare access.

Data were collected from 55 individuals. 51% identified as male, 48% as female, and 2% as LGBTQIA+. 67% identified as White/Caucasian, …

The Effect Of Abdominal Insufflation On Transversus Abdominis Plane (Tap) Block Efficacy In Laparoscopic Gynecologic Surgery, Hussein A. Bazzi, Justin Hruska M.D., Christopher Kliethermes M.D., Anne Thomas, Wael Saasouh M.D.

Medical Student Research Symposium

Introduction:

Approximately 15 million laparoscopic procedures are performed annually worldwide, with 4.8 million (32%) occurring in the United States. Laparoscopy is widely used for procedures such as bilateral tubal sterilizations, hysterectomies, and treatments for endometriosis and adhesions. During gynecologic laparoscopic surgeries, the abdomen is inflated with pressurized carbon dioxide for surgical visualization. Pain management typically involves a transversus abdominis plane (TAP) block, which provides intermediate postoperative pain relief (lasting 12–24 hours). This study evaluates the efficacy of TAP blocks performed during insufflation to improve postoperative pain outcomes compared to the traditional technique.

Methods:

This patient-blinded study included female gynecologic patients …

Measures Of Digital Health Literacy: A Scoping Review, Jessica Elderkin, Eliza Beal, Leva Gorji

Medical Student Research Symposium

Title: Measures of Digital Health Literacy: A Scoping Review

Authors: Leva Gorji, DO; Jessica Elderkin, BA; Eliza W. Beal, MD

Background: In the evolving field of medicine, electronic information and communication technologies have become profound tools for combating obstacles related to geographic barriers. As such, understanding and improving digital health literacy (DHL) is imperative to ensure that this form of healthcare is appropriately accessible to users. The objective of this scoping review is to gauge the tools available for assessing DHL.

Methods: A scoping review was conducted following the preferred reporting items for systematic review and meta-analyses (PRISMA) guidelines. In …

Investigating The Effects Of Intranasal Esketamine On Suicidal Ideation In Patients With Treatment-Resistant Depression, Ciara White, Izma N. Khaliq, Nicholas Mischel, Kirsten Brinkmeier

Medical Student Research Symposium

Treatment-resistant depression (TRD) remains a significant challenge, with many patients failing conventional treatments. While intranasal esketamine has demonstrated efficacy for depression, its specific effects on suicidal ideation (SI)—a critical symptom of depression—are underexplored. Unlike most studies that adhere to the 84mg dosing paradigm administered twice weekly, this study explores the novel use of varying esketamine doses, including 54mg, 84mg, and 112mg. This study aims to evaluate the impact of varying esketamine doses (54mg, 84mg, and 112mg) on SI in a real-world outpatient population (n=24). This study analyzed data from patients in Southwest Michigan with major depressive disorder (MDD) and psychiatric …

Efficacy Of First Aid Training In The Curriculum Of First Year Medical Students, Timothy Chalom, Sophia L. Braun, Laura Elizabeth Sansoterra, Kevin Chau, Zaid Y. Saadeh, Parmida Abdoli, Charles Hughes, Kristiana Kaufmann

Medical Student Research Symposium

Background

First Aid First (FAF) provides free and accessible first aid training to members of the Detroit community, including first-year medical students, to empower individuals to respond quickly properly, and confidently during real life emergencies.

Methods

First aid training sessions last 1.5 hours, and are taught by Wayne State University School of Medicine (WSUSOM) medical students and physicians. FAF trains incoming WSUSOM medical students on CPR, Stop the Bleed, and many more skills. Didactic instruction and hands-on demonstration allows participants to practice skills under the guidance of trained instructors. A pre-/post 20-question quiz on emergency responses and any prior first …

Complications Of Breast Reconstruction: Does The Area Deprivation Index Predict Risk?, Andrew Hannoudi, Noah M. Atisha, Amolak S. Jhand, Kinan Sawar, Dunya M. Atisha

Medical Student Research Symposium

INTRODUCTION: Despite mandated post-mastectomy reconstruction coverage since the Women’s Health and Cancer Rights Act (1998), vulnerable populations may be prone to breast reconstruction complications. The Area Deprivation Index (ADI) reflects neighborhood socioeconomic status utilizing US census data. This study investigates ADI's relationship to breast reconstruction complications.
METHODS: A retrospective study of immediate pre-pectoral direct-to-implant reconstruction patients at a metropolitan healthcare system from 2018-2022 was conducted. Patients were stratified by ADI: <50th percentile (ADI=1-5) and ≥50th percentile (ADI=6-10). Demographics, medical history, treatment history, and postoperative outcomes were compared. Descriptive statistics identified differences between ADI groups. Minor complications were defined as incidence of hematoma, seroma, superficial wounds, full thickness necrosis, or oral antibiotic-treated cellulitis. Major complications were defined as incidence of hospital readmission or return to OR. Long-term complications were defined as incidence of capsular contracture or ≥3 revisions. Logistic regression assessed ADI’s predictive value, accounting for confounds between cohorts.
RESULTS: Of 195 patients, 147 had low ADI and 48 had high ADI. Significant differences in BMI and race were found between groups. Low ADI demonstrated higher …

A New Paradigm For Looking At Infertility: A Pilot Study From Metropolitan Detroit, Indrea Joplin, Tonia Jones, Melanie Hanna-Johnson, Md, Anil N. F Aranha

Medical Student Research Symposium

No abstract provided.

Clinical Characteristics And Outcomes Of Pediatric Staphylococcal Scalded Skin Syndrome (Ssss) At An Inner-City Tertiary Care Center, Nina Kb Gust Md, Ashley Frei Bs, Rebecca M. Adams Bs, Elika Ridelman Phd, Christina Shanti Md, Ronald Thomas Phd, Jocelyn Y. Ang Md

Medical Student Research Symposium

Introduction

Staphylococcal Scalded Skin Syndrome (SSSS) is a blistering skin condition caused by a toxin-producing staphylococcus species. Epidemiologic studies on pediatric SSSS in the United States are limited, with a reported incidence of 7.67 cases per million children and 45.1 per million infants. Immature renal function, lack of protective antibodies, and increased exotoxin target desmoglein-1 are hypothesized to increase incidence in younger children. We aimed to determine clinical and microbiological characteristics of pediatric SSSS and factors that could help predict disease severity.

Methods

A retrospective chart review was performed for admitted patients under 18 years old diagnosed with SSSS from …

Socioeconomic Disparities And Challenges In Urban Detroit: Predicting Loss To Follow-Up After Treatment For Intracranial Aneurysms, Hailey Yasmine Rizk, Noah Goldberger, Jared Reese, Pouya Entezami

Medical Student Research Symposium

Intracranial aneurysmal subarachnoid hemorrhages (aSAH) can cause debilitating acute and chronic symptoms, and loss-to-follow-up (LTF) is a prominent issue affecting longitudinal care. Higher rates of follow-up have been correlated with better outcomes, and this study sought to identify disparities in the urban Detroit patient population and factors that may predispose patients to not receiving post-hospitalization care.

This retrospective study identified 352 patients with ruptured aSAH from 2013-2024 treated within a metro-Detroit hospital system. LTF was defined as lack of follow-up imaging >500 days post-discharge. Patient demographics and socioeconomic variables were reviewed, and Chi-square and Fisher’s tests were utilized to determine …