Medicine and Health Sciences Commons^™

Institutional Connectedness And Social Support Among College Students: Links To Campus Involvement, Carissa Strum

Honors Theses

Background. College is a pivotal period in the lives of students, and an important aspect of the experience is involvement within the campus. College student wellness is also a growing area of interest in higher education, with increased attention on ways to help students thrive. This study explores which aspects of campus involvement contribute to students’ feelings of connectedness and social support. This study aims to 1) assess the association between campus involvement and social support among college students, 2) assess the association between campus involvement and institutional connectedness among college students, and 3) examine whether the association between campus …

Over-The-Counter Cold Medication Usage Self-Efficacy Among Undergraduate Students In The United States, Ray Goodwin

Honors Theses

Background

This study looks at the trends in over-the-counter medication usage and self-efficacy among undergraduate college students in the United States. Over-the-counter (OTC) medications serve as the most easily accessible and commonly purchased medications and can be used as a basis to determine this demographic’s attitudes and behaviors towards self-medication. In addition, undergraduates represent a diverse population for analyzing differences among demographic groups.

Methods

A Qualtrics survey was sent out to undergraduates across the US via a panel, and the team received 403 useable responses. As part of a larger study, the survey presented participants with four different scenarios at …

Associations Between Tiktok Use And Undergraduate Nursing Professional Identity, Parker M. Watts

Honors Theses

Background. The global surge in social media usage prompts extensive research into its links with nursing professional identity. College-aged individuals who are in nursing school or are going to be in nursing school in the future must navigate their professional identity as they face heightened susceptibility to subjective opinions about the career of a nurse due to their frequent engagement with social media platforms. Among these platforms is that of TikTok, a platform of which has rapidly gained traction, especially among younger demographics. TikTok remains relatively underexplored in terms of its impact on nursing professional identity. This study seeks to …

Effects Of Acute Exercise On Cognition: Consideration Of Potential Moderators, Lucy C. Wilson, Elizabeth Carwile, Mara Liston, Elizabeth Gaines, Mckenzie Cotten, Mary Griffin

Honors Theses

The present thesis aims to determine the effects, if any, of six potential moderators on the effects of acute moderate-intensity exercise on cognitive functioning. The modes of exercise undertaken by the participants included treadmill (Experiment 1) and stationary bike (Experiment 2) exercise. Participants in each experiment either exercised or rested for twenty minutes and then participated in either a memory recall task or cognitive functioning (“Stroop”) task. The bouts of either exercise or rest on the stationary bike were followed by a rest period during which the participant would be exposed to either standard air oxygen levels (normoxia) or hypoxic …

A Search For Transcriptional Cofactors Of Gcm/Repo Involved In Determining Glia Cell Fate In Drosophila Melanogaster, Nivedha Kosalram

Honors Theses

In Drosophila melanogaster, the mechanism influencing the differentiation of glia and neurons is directed by a key transcription factor known as glial cells missing (gcm). gcm is a crucial regulator of cell fate decision, functioning as a binary switch to direct glial fate in gcm- positive cells and neuronal fate in gcm-negative cells (Jones, et.al, 1995; Hosoya, et.al, 1995; and Vincent, et.al, 1996). In addition to directing gliogenesis, gcm and its homolog gcm2 facilitate the determination of macrophages and tendon cells, highlighting that gcm acts with supplementary factors to induce various signaling pathways in different contexts (Jones, 2005; Johnson, et …

Empowering Youth Through Cooking Classes, Jamiya C. Mason

Honors Theses

Chronic health issues and poor dietary habits continue to disproportionately impact rural communities in Mississippi, especially among children. Research has shown that early exposure to healthy foods and cooking practices can positively influence lifelong health behaviors. Cooking classes have also been linked to improved food literacy, culinary confidence, and willingness to try new foods. The purpose of this study was to assess the effects of a short-term culinary program on children’s cooking self-efficacy and food behaviors in Quitman County, Mississippi.

Four cooking classes were conducted with youth (grades 4–7) in a local after-school program. Lessons included vegetable-based recipes, including zucchini …

Health Equity And Social Determinants Of Health Nurse Education, Jacqueline Arana Clements

Walden Dissertations and Doctoral Studies

The primary care setting provides integrated healthcare services where nurses address many healthcare needs, develop patient relationships, and practice in the context of family and community. To provide comprehensive care, nurses must complete a social determinants of health screening that addresses the social factors that impact clinical outcomes. In 2021, the National Academies of Sciences, Engineering, and Medicine published a nursing education strategy on educating nurses on social determinants of health. This project aimed to develop a staff education program to prepare primary care nurses on the concepts and terminology encompassing social determinants of health, identifying the severity of health …

Congress Of Neurological Surgeons Systematic Review And Evidence-Based Guidelines For The Role Of Imaging In Newly Diagnosed Who Grade Ii Diffuse Glioma In Adults: Update, Chaitra Badve, Abraham Nirappel

Faculty Scholarship

Target population: Adult patients with suspected or histologically proven WHO Grade II diffuse glioma. Question 1: In adult patients with suspected or histologically proven WHO Grade II diffuse glioma, do advanced MRI techniques using magnetic resonance spectroscopy, perfusion weighted imaging or diffusion weighted imaging provide superior assessment of tumor grade, margins, progression, treatment-related effects, and prognosis compared to standard neuroimaging? Recommendation: Level II: The use of diffusion imaging and dynamic susceptibility contrast (DSC), dynamic contrast enhancement (DCE) and arterial spin labeling (ASL) sequences are suggested to differentiate WHO Grade II diffuse glioma from higher grade gliomas when this is not …

Small Steps For A Big Change: A Longitudinal Project To Enhance Well-Being Of Internal Medicine Residents, Vandana Nagpal, Benjamin Tanenbaum, Christine Runyan

Journal of Wellness

Introduction: Residency training is demanding and often leads to burnout. In 2017, Internal Medicine (IM) residents at our institution reported a poor collective residency experience. In response, we launched a longitudinal wellness program in 2018, featuring multi-pronged interventions to improve residents' well-being. The program, still active today, has undergone iterative modifications with ongoing input from residents.

Approach: The resident-led Wellness Committee was established in 2018, and the following no to low-cost initiatives were implemented sequentially: quarterly group sessions with an institutional health psychologist, bi-annual self-checks, peer buddy support for incoming first-year residents, weekly 5-minute reflection sessions, and volunteer dog visits. …

Identification Of Subtypes Of Post-Stroke And Neurotypical Gait Behaviors Using Neural Network Analysis Of Gait Cycle Kinematics, Andrian Kuch, Nicolas Schweighofer, James M. Finley, Alison Mckenzie, Yuxin Wen, Natalia Sánchez

Physical Therapy Faculty Articles and Research

Gait impairment post-stroke is highly heterogeneous. Prior studies classified heterogeneous gait patterns into subgroups using peak kinematics, kinetics, or spatiotemporal variables. A limitation of this approach is the need to select discrete features in the gait cycle. Using continuous gait cycle data, we accounted for differences in magnitude and timing of kinematics. Here, we propose a machine-learning pipeline combining supervised and unsupervised learning. We first trained a Convolutional Neural Network and a Temporal Convolutional Network to extract features that distinguish impaired from neurotypical gait. Then, we used unsupervised time-series k-means and Gaussian Mixture Models to identify gait clusters. We tested …

Demographic And Clinical Factors Associated With Mechanisms Of Open Globe Injury In The United States: A Multi-Center Study, Shruti Anant, Alicia Casella, Jason A. Greenfield, Sarah C. Miller, Kristine Y. Wang, Bita Momenaei, Karen Lee, Hana A. Mansour, Grant A. Justin, Kevin G. Makhoul, Racquel A. Bitar, Alice Lorch, Grayson W. Armstrong, Taku Wakabayashi, Yoshihiro Yonekawa, Kara M. Cavuoto, Fasika Woreta

Wills Eye Hospital Papers

PURPOSE: We sought to examine the demographic and clinical risk factors associated with specific mechanisms of open globe injuries (OGIs) and identify predictors of Zone III injuries across multiple tertiary eye care centers.

PATIENTS AND METHODS: 1570 patients with OGIs presenting to the Wilmer Eye Institute, the Bascom Palmer Eye Institute, Massachusetts Eye and Ear, and Wills Eye Hospital between 2018-2021 were retrospectively reviewed. Multinomial and binomial logistic regression models were used to evaluate associations between demographic and clinical risk factors with injury mechanisms and Zone III injuries.

RESULTS: Among the study population (74.2% male, mean age 48.2 years), falls …

Development Of A Risk Score To Aid With The Diagnosis Of Infections After Spinal Cord Injury: Protocol For A Retrospective Cohort Study, Felicia Skelton, Larissa Grigoryan, Joann Pan, Ashley Collazo, Barbara Trautner

Faculty, Staff and Students Publications

Background: Patients with spinal cord injury (SCI) who develop urinary tract infection (UTI) present differently than the non-SCI population. UTIs can cause loss of quality of life and even lead to life-threatening complications including urosepsis. Challenges in SCI management include distinguishing symptomatic UTI from asymptomatic bacteriuria (ASB), which occurs often in patients with SCI, and the lack of standardization in UTI diagnosis in SCI.

Objective: This study aims to set the foundation for the development of a risk score to improve diagnostic accuracy of UTI after SCI.

Methods: This study will use data from the Veterans Health Administration Corporate Data …

Improved Outcomes Of Acute Lymphoblastic Leukemia After Allogeneic Blood Or Marrow Transplantation With High-Dose Post-Transplantation Cyclophosphamide In The Era Of More Effective Pre-Transplant Therapy, Jonathan A Webster, Madison Reed, Hua-Ling Tsai, Philip H Imus, Douglas B Smith, Alexander J Ambinder, Mark J Levis, Amy E Dezern, Gabrielle T Prince, Tania Jain, Javier Bolaños-Meade, Lukasz P Gondek, Gabriel Ghiaur, William Brian Dalton, Theodoros Karantanos, Suman Paul, Ephraim J Fuchs, Cole Sterling, Lode J Swinnen, Nina Wagner-Johnston, Richard F Ambinder, Christian B Gocke, Syed Abbas Ali, Carol Ann Huff, Leo Luznik, Ravi Varadhan, Richard J Jones, Ivana Gojo

Faculty, Staff and Students Publications

The therapeutic landscape in ALL has changed dramatically over the last decade. Allogeneic blood or marrow transplantation (AlloBMT) has also evolved and remains an important option for consolidation. We assessed the interplay between these factors by analyzing the outcomes of 251 adult ALL (214 B and 37 T ALL) patients undergoing alloBMT with post-transplantation cyclophosphamide (PTCy) across two eras: 2008-2014 (ERA1) and 2015-2022 (ERA2). ERA1 patients were younger (median age 45.5 vs. 50, p=0.03), less likely to have an HCT-CI ≥4 (9% vs. 21%, p=0.01), more likely to have MRD by flow cytometry (20% vs. 9%, p=0.01) and receive myeloablative …

Human Genetic Variation Determines 24-Hour Rhythmic Gene Expression And Disease Risk, Ying Chen, Panpan Liu, Aniko Sabo, Dongyin Guan

Faculty, Staff and Students Publications

24-hour biological rhythms are essential to maintain physiological homeostasis. Disruption of these rhythms increases the risks of multiple diseases. Biological rhythms are known to have a genetic basis formed by core clock genes, but how individual genetic variation shapes the oscillating transcriptome and contributes to human chronophysiology and disease risk is largely unknown. Here, we mapped interactions between temporal gene expression and genotype to identify quantitative trait loci (QTLs) contributing to rhythmic gene expression. These newly identified QTLs were termed as rhythmic QTLs (rhyQTLs), which determine previously unappreciated rhythmic genes in human subpopulations with specific genotypes. Functionally, rhyQTLs and their …

Hippocampal-Prefrontal Functional Neural Networks In A Rat Model Of Fragile X Syndrome Are Poorly Organized With Limited Resiliency, Mohamed Ouardouz, Patrick Jasinski, Mohamed Khalife, J. Matthew Mahoney, Amanda E. Hernan, Rod C. Scott

Department of Neurology Faculty Papers

Fragile X Syndrome (FXS) is a common cause of autism spectrum symptoms. The genetic mutation results in multiple molecular alterations that are hypothesized to negatively impact neural circuit development although the nature of any functional neural dynamic consequences remain unclear. Therefore, the characteristics of hippocampal-prefrontal (H-PFC) network dysfunction were investigated in a rat model of FXS. FMR-KO and control rats underwent behavioral tests assessing sociability, memory, and anxiety to validate and replicate previously recognized deficits. Single-unit electrophysiology in the H-PFC circuit during exploration was used to measure patterns of action potential firing that were then compared between groups using generalized …

Staff Education On Bias Awareness, Macbarbara Amaechi

Walden Dissertations and Doctoral Studies

The project was a staff education initiative focused on addressing a knowledge gap about bias for treatment of patients on controlled substances at the practice site. I aimed to fill this practice gap by developing an education program that delivered evidence-based methods to reduce bias. The practice-focused question was: Will a staff education project result in an increase in staff knowledge and awareness around implicit bias among patients who are taking controlled substances? The purpose of the project was to determine if a formal educational program could enhance the knowledge of the staff and decrease bias, which would lead to …

Staff Education To Standardize Handoff Communication Protocols: Enhancing Patient Safety, Delali Adjele Tetteh-Assiakoley

Walden Dissertations and Doctoral Studies

Summary This doctor of nursing practice (DNP) staff education project focused on providing a staff education program on standardized handoff communication protocols to enhance patient safety and communication efficiency and effectiveness of information exchange at the practicum site. The practice problem is the lack of consistency regarding handoff communication, which results in miscommunication, inefficiencies, and possible preventable patient harm. Under conditions of poor handoff communication, medical errors, delays in treatment, and adverse patient outcomes are well documented. The project sought to improve the nursing staff’s knowledge of standardized handoff tools through a structured education program guided by the following practice-focused …

Youth-Driven Approaches To At-Home Dbs Hiv Monitoring: The Role Of Privacy, Clinical Trust, And Digital Tools, Cynthia Wen, Sitaji Gurung

Publications and Research

Dried blood spot (DBS) biosampling offers a convenient at-home option for HIV viral load monitoring, especially for youth facing clinic access barriers. This study explored youth perspectives on DBS through semi-structured interviews (n=6) from an NIH-funded project. Key themes emerged. Youth expressed a preference for discreet access and privacy was critical. They preferred clinic-based kit pickup and return to avoid stigma. Trust in clinic-promoted kits was important, as healthcare provider endorsement increased the credibility of the kits. Digital tools supported usability and awareness, with QR codes, video tutorials, and social media playing a significant role. Additional insights included the need …

Building Community Through Food And Health: Student Initiatives To Address Food Insecurity In Mississippi, Sarah E. Sawaya

Honors Theses

This thesis explores food insecurity in Oxford and Lafayette County, Mississippi, within the broader context of state, national, and global challenges. Over a four-year period, student-led and community organizations collaborated to design programs that addressed both food access and chronic illness prevention through education, outreach, and direct service. Community input was gathered through health screenings, campus engagement, and informal interviews with residents, which guided the development of practical tools like recipe kits, QR code-based cookbooks, and on-site health education. These efforts were rooted in local partnerships and shaped by the lived experiences of those most affected. This project demonstrates that …

Investigating Social Network Peer Effects On Hiv Care Engagement Using A Fuzzy-Like Matching Approach: Cross-Sectional Secondary Analysis Of The N2 Cohort Study, Cho-Hee Shrader, Dustin T Duncan, Redd Driver, Juan G Arroyo-Flores, Makella S Coudray, Raymond Moody, Yen-Tyng Chen, Britt Skaathun, Lindsay Young, Natascha Del Vecchio, Kayo Fujimoto, Justin R Knox, Mariano Kanamori, John A Schneider

Faculty, Staff and Student Publications

BACKGROUND: Social network data are essential and informative for public health research and implementation as they provide details on individuals and their social context. For example, health information and behaviors, such as HIV-related prevention and care, may disseminate within a network or across society. By harmonizing egocentric and digital networks, researchers may construct a sociocentric-like "fuzzy" network based on a subgroup of the population.

OBJECTIVE: We aimed to generate a more complete sociocentric-like "fuzzy" network by harmonizing alternative sources of egocentric and digital network data to examine relationships between participants in the Neighborhoods and Networks (N2) cohort study. Further, we …

Is Anterior Cervical Discectomy And Fusion More Expensive At Quaternary Care Centers? An Application Of Time-Driven Activity-Based Costing, Jay Trivedi, Advith Sarikonda, Adam Leibold, D. Mitchell Self, Nikolaos Mouchtouris, Steven R. Glener, Ashmal Sami, Kavantissa M. Keppetipola, Emily Isch, Joshua Pelta-Heller, Srinivas Prasad, Ashwini Sharan, James Harrop, Alex R. Vaccaro, Ahilan Sivaganesan

Department of Neurosurgery Faculty Papers

OBJECTIVE: Hospital setting is postulated to be a key driver of cost variation for neurosurgical procedures. Limitations in contemporary costing methodologies have led to the development of time-driven activity-based costing (TDABC). This study applies TDABC to anterior cervical discectomy and fusion (ACDF) to compare intraoperative costs at quaternary care centers versus satellite hospitals affiliated with the same health network.

METHODS: Nine hundred and fifty-eight ACDF cases performed at two quaternary care hospitals (n = 806) and six satellite hospitals (n = 152) were reviewed. Process maps were created to map the intraoperative episode, and TDABC methodology was used to calculate …

Sirt6 Deficiency Promotes Senescence And Age-Associated Intervertebral Disc Degeneration In Mice, Pranay Ramteke, Bahiyah Watson, Mallory Toci, Victoria Tran, Shira N Johnston, Maria Tsingas, Ruteja Barve, Ramkrishna Mitra, Richard Loeser, John Collins, Makarand Risbud

Department of Orthopaedic Surgery Faculty Papers

Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan^CreERT2; Sirt6^fl/fl). Histological studies showed a degenerative phenotype in knockout mice …

Rationale For A 4-Month, Parallel-Group, Randomized Controlled Trial To Assess The Feasibility And Efficacy Of A Remotely Delivered Exercise Training Intervention For Hispanics/Latinos With Multiple Sclerosis (Ferla Ms), Victoria A Flores, Stephanie L Silveira, David X Marquez, Dominique Kinnett-Hopkins, Augusto Miravalle, Fabian Sierra-Morales, Zulma Hernández-Peraza, Robert W Motl

Faculty, Staff and Student Publications

Background: Hispanic/Latino individuals with multiple sclerosis (MS) face greater disease burden and comorbidity due to limited healthcare access, underrepresentation in research, and social determinants of health (SDOH). Exercise training could manage health outcomes, but existing intervention research lacks Hispanic/Latino representation.

Methods: We propose a feasibility and efficacy study of a theory-based, remotely delivered exercise training intervention for enhancing health outcomes in Hispanics/Latinos with MS. This study involves a randomized controlled trial (RCT) design and compares an MS-specific exercise training program with an active control condition over a 4-month period in a sample of 50 individuals who self-identified as Hispanic/Latino with …

Staff Education To Address Communication In Correctional Healthcare, Pamela Renee Bredy

Walden Dissertations and Doctoral Studies

This doctoral project was a staff education initiative focused on enhancing staff knowledge of Situation Background Assessment Recommendations (SBAR) communication through structured educational intervention in correctional healthcare settings. The practice problem centered on significant deficiencies in standardized communication. The practice-focused question was, Will implementing staff education on SBAR communication increase staff knowledge and confidence? I aimed to enhance staff communication and knowledge through SBAR implementation using live sessions, hands-on practice, and reference materials.

Investigating The Association Between Metabolically Healthy And Metabolically Unhealthy Obesity With Disease, Colleen Marie Cohick

Walden Dissertations and Doctoral Studies

Obesity is a global health concern, affecting individuals of all ages and ethnicities worldwide. A key factor in health concerns related to obesity is metabolic health: Obese individuals are either metabolically healthy obese or metabolically unhealthy obese, leading to different degrees of risk for cardiovascular disease and diabetes.. There is a lack of comprehensive research examining the association between metabolic health status among obese individuals and kidney, liver, and stomach diseases. This quantitative cross-sectional study was conducted to examine whether metabolic health status is a significant predictor of kidney, liver, and stomach diseases among obese individuals when lifestyle is a …

Reducing Medical Supplies Waste By Managing Healthcare Resources In A Clinical Setting In The United States: Lessons Learned From The Covid-19 Pandemic, Chiatuogu Anna Ukaga

Walden Dissertations and Doctoral Studies

The gap in practice identified for my DNP capstone project is reducing medical supplies waste by managing healthcare resources in a clinic setting in the United States of America. The Organizational Change Process (OCP) Evaluation project assessed a tracking and exchange system to track the inventory of supplies used in different worksite clinics and their expiration dates. Knowledge of the expiration dates enabled exchange or shift to high-utilization areas before the supplies expired, thereby reducing waste, costs, and environmental pollution. The healthcare organization was a mix of ambulatory clinics and hospitals of varying scopes and sizes. The small clinics served …

The Ethical Imperative Of The Renewal Of Virtue Within The Moral Community Of Catholic Healthcare, Amanda Altobell

Electronic Theses and Dissertations

Catholic healthcare is one of the largest nonprofit organizations and providers in the United States, offering medical care to many diverse communities. The fundamental mission of Catholic healthcare is to bring about Christ’s healing ministry and live out the fundamental principle of caring for the vulnerable in pursuit of the common good. However, there have been many missteps, not only due to a more polarized and secular community but also to scandals and conflict due to previous hierarchical and rules-based anthropology that often misses the person's lived experience. Therefore, this dissertation will argue that for Catholic healthcare to survive the …

Health Fairs: An Effective Approach To Health Promotion Through Community Engagement And Community-Campus Partnerships, Brookleigh Brumfield

Honors Theses

Community engagement seeks to achieve long-term outcomes through collaborating with community and campus partners to address the issues affecting the community by centering their voices, concerns, and solutions. This capstone project seeks to offer health and language access for residents in Lafayette, Pontotoc, and Union Counties, and to evaluate the health fair model from the perspective of participating community and campus partners. With this information from organizations, it will be possible to create the most efficient, beneficial health fairs in these counties. The community partner perspectives show the importance of community engagement, but also the significance for the campus as …

Empathy And Psychological Outcomes In Informal Caregivers Of Community-Dwelling Older Adults: A Systematic Review And Meta-Analysis, Meng Huo, Thi Vu, Tomiko Yoneda, Jingkai Wei, Bruce Abbott, Joan K Monin

Faculty, Staff and Student Publications

Objectives: Scholars have increasingly recognized the crucial role that empathy plays as informal caregivers provide unpaid care to their older family and friends (i.e., care recipients). Yet, the existing literature exhibits substantial variability in study approaches and results, which limits the extent to which this literature can inform interventions intended to benefit informal caregivers. We sought to address this critical gap by synthesizing research that examined how caregivers' and care recipients' empathy were associated with caregivers' psychological health.

Methods: We conducted a literature search using PubMed, PsycInfo, CINAHL (Cumulative Index to Nursing and Allied Health Literature), EMBASE, and Scopus databases …

Brain And Cerebrospinal Fluid 3d Center Of Mass Shift After Spaceflight, Katherine G Warthen, Stuart H Sater, Larry A Kramer, Khader M Hasan, Michael A Williams, Millennia Young, Brandon R Macias, Steven S Laurie, Bryn A Martin

Faculty, Staff and Student Publications

A subset of long-duration spaceflight astronauts at the International Space Station has been documented to develop spaceflight associated neuro-ocular syndrome (SANS). Researchers have sought to understand SANS by quantification of ocular and brain structural changes thought to be associated with weightlessness induced headward fluid shift. Brain tissue shift and cerebrospinal fluid (CSF) redistribution has been observed as measured by MRI on return to Earth, and not fully quantified. To improve the understanding of this phenomenon, we developed and applied automated methods to quantify 3D center of mass shift within the skull of the extra-axial cerebrospinal fluid (eaCSF) and brain after …