Medicine and Health Sciences Commons^™

Mesoderm-Specific Transcript Has A Role In The Systemic Regulation Of Obesity, Maria J. Orellana Rosales

Thinking Matters Symposium

Mesoderm specific transcript (Mest) expression in white adipose tissue (WAT) is variable in genetically identical mice. Previous studies have shown a connection between Mest high expression and propensity for fat mass expansion. WAT and liver crosstalk has been well documented with hormone-like peptides signaling and regulating important metabolic pathways. The aim of this study is to investigate the correlation between these circulating factors and Mest expression in mice after exposure to a high fat diet (HFD). A group of 120 C57B6/J mice, males and females, were exposed to a HFD (Western Diet, 40 kcal% fat) for 4 weeks (8-12 weeks …

An After-School Adaptive Bicycle Program For Children With Disabilities: A Pilot Feasibility Study, Makenzie Dietz, Nicole Fuchs, Alli Hill, Kloe Muntz, Megan Petric, Sophia Wahib, Betsy Donahoe-Fillmore, Trisha Renner

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: Cycling has broad health benefits and is therapeutic across many populations. Physical therapists commonly fit children with gross motor delays for adaptive bicycles and assist with training during therapeutic intervention. Limited evidence exists regarding formalized adaptive bicycling programs apart from traditional therapy. The primary aim of this study was to investigate if an after-school adaptive cycling program is feasible in children with motor delay. The secondary aim was to determine if it can improve balance, endurance and functional strength in children with disabilities.

Number of Subjects: Ten children with motor delays, ages 6 to 11 (mean 7.7) years participated. …

Real-World Management Of High-Risk Prostate Cancer Post-Radical Prostatectomy: Insights From A Regional Quality Collaborative, Aaron R. Hochberg, Annie H. Ho, Rasheed A. M. Thompson, Matthew B. Buck, Costas D. Lallas, Christine Ibilibor, Jeffrey J. Tomaszewski, Serge Ginzburg, Andres Correa, Robert Uzzo, Marc C. Smaldone, John F. Danella, Thomas J. Guzzo, Daniel J. Lee, Laurence Belkoff, Jeffrey Walker, Jay D. Raman, Roderick K. Clark, Adam Reese, Bruce Jacobs, Thomas Jang, Keith J. Kowalczyk, Meghan Smith, Mihir S. Shah

Department of Urology Faculty Papers

Background/Objectives: Data from clinical trials showing the non-inferiority of early salvage radiotherapy were recently incorporated into societal guideline statements. However, questions remain regarding ideal prostate-specific antigen (PSA) criteria for salvage, and how to apply these findings to pathologic lymph node-positive (pN+) disease. We investigated variance in management of clinically localized prostate cancer found to have high-risk features after radical prostatectomy. Methods: We retrospectively identified patients from May 2015 to January 2024 utilizing a multi-institutional, regional collaborative database. The primary outcome was identifying factors associated with the receipt of adjuvant versus salvage therapy. Factors associated with secondary treatment were assessed via …

Improving Interactions During Medical Interpretation: Educational Module For Medical Students, Alyssa Reinschmidt, Denyelle Kenyon, Hilda Sanchez-Herrera

Scholarship Pathways Program

As the population of individuals with limited English proficiency (LEP) continues to grow in South Dakota and across the United States, healthcare systems face increasing challenges in providing equitable care. This study evaluates the implementation of an educational module designed to prepare first-year medical students at the University of South Dakota Sanford School of Medicine (SSOM) to work effectively with medical interpreters and patients with LEP. The module included a didactic session, role-play, open discussion, and pre- and post-surveys assessing students’ knowledge, attitudes, preparedness, and perceptions of the educational environment. Results from 68 participants demonstrated statistically significant improvements across all …

Effects Of Calcineurin Mediated Immunosuppressant Cyclosporine On Binge Alcohol Drinking And Stress Responsivity, Brock Goeden, Emily Dorn, Jennifer Agar, Thomas P. Beresford, Patrick J. Ronan

Scholarship Pathways Program

Stress and neuroinflammation are increasingly recognized as interdependent processes that contribute to the development of psychiatric disorders. This study investigates the bidirectional relationship between stress exposure and neuroimmune activation, focusing on the expression of pro-inflammatory cytokines and behavioral outcomes in rodent models. Using the learned helplessness (LH) paradigm, the authors demonstrate that stress-induced neuroinflammation, particularly elevated IL-1β expression in the hypothalamus, is associated with susceptibility to maladaptive behaviors. The immunosuppressant cyclosporine A (CsA) was shown to attenuate stress-induced expression of neuroinflammatory markers, including IL-1β, IL-6, and CRF. Furthermore, direct intracerebroventricular administration of lipopolysaccharide (LPS), a TLR4 agonist, induced LH-like behavioral …

Infections And Patient Satisfaction For Walant Hand Surgery In Hospital Procedure Room, Michaela Derby, Kelly N. Mcknight, Robert E. Van Demark Jr.

Scholarship Pathways Program

Background: Wide awake hand surgery has allowed many hand procedures to be moved out of the operating room and into minor procedure rooms while increasing efficiency, maintaining safety, and reducing both patient and hospital costs. The goal of this study was to evaluate patient satisfaction and postoperative complications of wide-awake local anesthesia with no tourniquet procedures performed in a community-based hospital procedure room.

Methods: A total of 786 patients underwent 948 elective hand procedures in a hospital procedure room. At the conclusion of their surgeries, the patients were surveyed regarding their satisfaction. Following surgery, patients were evaluated for postoperative complications …

Expanding “Brain Games”: What Have We Learned From A Program Designed To Support Healthy Brain Aging In Older Adults?, Ella Mckinney

Honors Capstones

This study was part of a larger investigation examining the feasibility and impact of “Brain Games,” an intergenerational program designed to provide brain health education and cognitive training for healthy aging adults to maximize cognitive function and quality of life. The purpose of this project was to explore whether and how short- and long-term effects of “Brain Games” were tempered by demographic variables, including cognitive self-efficacy and socioeconomic factors. Study participants included older adults residing in two senior living centers in the DeKalb area. All participants received cognitive training and brain health education via “Brain Games”, which was offered in …

Application Of Bioactive Materials Primary Cilia As A Novel Delivery Vehicle, Ayan K. Barui, Farideh Amirrad, Vansh Goel, Sharareh Ohadi, Rajasekharreddy Pala, Ashraf M. Mohieldin, Andromeda M. Nauli, Surya M. Nauli

Pharmacy Faculty Articles and Research

Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm), mental impedances (Alzheimer's disease, Parkinson's disease, dementia), metabolic diseases (obesity, developmental skeleton defects), blindness, and so on. With a diameter of 150 nm, cilia can be cleaved, released and circulated in the body as injury biomarkers. We here assessed the potential use of isolated cilia as a novel delivery vehicle. Cilia were isolated from renal epithelial cells, and a specific-targeting chemotherapeutic was designed on the cilia. The data show a remarkable …

Leadership And Team Communication Course For Medical Students As Future Healthcare Leaders, Claire Foerster

Scholarship Pathways Program

As healthcare increasingly adopts a team-based model to address complex patient needs, the role of physicians as effective team leaders becomes critical. Despite this, formal leadership training is not a standard component of medical school curricula. This study presents the development and evaluation of a pilot leadership and communication course designed for medical students at the University of South Dakota. The course combined didactic instruction with simulation-based learning to teach essential skills such as active listening, giving and receiving feedback, and effective communication. A pre-course survey assessed students’ confidence and needs, informing the course design. Post-course assessments, including quizzes and …

Lightning Assocated With More Visits To The Ed For Chest Pain, Bailee Lichter, Benjamin Aaker

Scholarship Pathways Program

This study investigates the potential association between lightning events,used as a proxy for thunder, and increased emergency department (ED) visits for chest pain and myocardial infarction (MI). Electronic medical records from Avera McKennan Hospital were analyzed for chest pain and MI diagnoses between June 1 and July 31, 2021. Lightning data within a 100-mile radius were obtained from Vaisala and cross-referenced with patient presentation times. Statistical analysis revealed a significant increase in chest pain-related ED visits within 0.5 hours and between 2.5 to 5.5 hours following lightning strikes, with p-values ranging from 0.018 to 0.047. Although a trend toward increased …

Transitional Understanding Of Kindness In Medical Students, Madigan Moore, Jerome Freeman, Ann Cook, Jamie Messerli

Scholarship Pathways Program

This qualitative study explores how medical students at the University of South Dakota Sanford School of Medicine understand and practice kindness throughout their medical education. Through individual interviews and focus groups conducted in two phases, before and after clinical immersion, the research identifies four central themes: definition of kindness, clinical environments, provider practices, and ethics. Findings reveal that students initially view kindness as an innate trait but increasingly recognize it as a deliberate decision influenced by clinical challenges. Contextual factors such as time constraints, emotional exhaustion, and negative work environments were found to hinder expressions of kindness. Students also noted …

Developing Program Infrastructure For Effective Intercultural Education At The Sanford School Of Medicine, Andrew Nerland, Denyelle Kenyon

Scholarship Pathways Program

This study evaluates the intercultural patient care education at the University of South Dakota Sanford School of Medicine (USD-SSOM) through a mixed-methods survey of medical students. The research explores student perspectives on the importance, effectiveness, and preferred formats of intercultural education, with a focus on preparing future physicians to serve diverse and underserved populations. Findings reveal strong student endorsement of intercultural education but mixed satisfaction with current programming, particularly among female and non-white respondents. Students expressed a preference for longitudinal, required, and in-person education delivered in clinical and community settings. Topics such as Native American health disparities, LGBTQ+ care, and …

Maternal Food Insecurity And Adverse Birth Outcomes, Narysse Nicolet, Amrita Bhagia, Katie Ziegler, Lacey Mccormack, Amy Elliott, Christine Hockett

Scholarship Pathways Program

Background: Despite being a high-income country, the United States faces persistent food insecurity (FI), disproportionately affecting women of reproductive age. This study investigates the association between prenatal FI and adverse birth outcomes, specifically birth weight (BW) and gestational age (GA), among a diverse cohort of pregnant individuals in South Dakota.

Methods: A longitudinal analysis was conducted using data from 1,478 mother-infant pairs enrolled in the Safe Passage Cohort of the ECHO study. Prenatal FI was assessed using a modified USDA Household Food Security Questionnaire. Birth outcomes were analyzed using both univariate and multivariate regression models, adjusting for maternal sociodemographic and …

Ultrasonographic Accuracy In Rural Vs Urban Counties, Riley T. Paulsen, Avery D. Franzen, Amy M. Eichfeld, Laurie Landeen

Scholarship Pathways Program

Background: Rural communities in the United States face significant barriers to prenatal care, including limited access to birthing facilities and obstetric providers. Accurate prenatal ultrasonography is essential for identifying congenital anomalies and predicting birth outcomes, particularly in these underserved areas.

Objective: This study aimed to evaluate whether ultrasonographic accuracy differs between rural and urban counties, specifically in predicting birth weight and detecting congenital anomalies.

Methods: A retrospective chart review was conducted using data from the Sanford Health system. Maternal and fetal data were collected from second trimester ultrasounds and compared with postnatal outcomes. Counties with populations under 50,000 were classified …

Utilizing Registered Dietitians To Improve Nutrition Education For Medical Students, Andee James, Pasquale Manzerra

Scholarship Pathways Program

Despite the well-established link between nutrition and chronic disease prevention, medical education continues to underemphasize nutrition training. This study explores the impact of integrating registered dietitians (RDs) into pre-clerkship medical education to enhance students’ knowledge, confidence, and perception of nutrition in clinical care. A series of optional, system-based nutrition lectures were delivered by RDs and supplemented by senior medical students who shared real-world clinical case studies. Pre- and post-session surveys assessed students’ confidence in providing dietary counseling, understanding of the physician’s and dietitian’s roles, and the perceived importance of nutrition in disease management. Results showed significant improvements across all metrics, …

Walk With Ease Benefiting South Dakota, Bailey Thooft, Jennifer Kerkvliet

Scholarship Pathways Program

The Walk With Ease (WWE) program is a free, evidence-based, six-week walking initiative originally developed by the Arthritis Foundation to support adults with arthritis and other chronic conditions. This study evaluates the impact of WWE in South Dakota, focusing on participant outcomes related to overall health, physical activity, and chronic condition management. Participants engaged in either instructor-led or self-directed formats and accessed an online portal for resources. Pre- and post-surveys revealed that most participants improved or maintained their health metrics, with 44% reporting improved management of chronic conditions and 30% increasing daily walking time. The online portal was well-received, with …

Disability Lectures, Panel Discussion Improve Medical Student Attitudes, Knowledge In Sd, Keely Walker, Eric Kurtz

Scholarship Pathways Program

Despite growing recognition of persons with disabilities (PWDs) as an underserved population, healthcare disparities persist, often exacerbated by provider misconceptions and lack of training. This study evaluated the impact of a two-part educational module consisting of a didactic session and a panel discussion with individuals with disabilities focused on healthcare students’ knowledge and comfort in caring for patients with intellectual and developmental disabilities (IDDs). Conducted at the University of South Dakota, the sessions included pre- and post-surveys assessing attitudes, confidence, and perceived competencies. Results from 35 participants, primarily medical students, showed statistically significant improvements in 11 of 13 measured domains, …

Minimizing Grief And Loss Through Advance Care Planning, Hannah Paauw, Victoria Walker

Scholarship Pathways Program

Advanced Care Planning (ACP) is a process used to identify or update a specific patient’s preferences of care and treatment in the event that they lack the capacity to do so. ACP is especially important for the aging population and those living with chronic conditions. Currently 11% of the world’s population is above the age of 60 and this number is projected to climb to 22% by 2050. The effects of aging are even greater in rural areas, such as South Dakota, where there is a disproportionate number of older and sicker people.

This study examined the effectiveness of a …

School Nurses' Role In Creating A Culture Of Preparation For Cardiac Emergencies, Dena L. Hinkle, Marisa A. Dressler, Katherine M. Miller, Shannon L. Beetz

Nursing Department Graduate Presentations/Conferences

Recent legislation in Illinois schools has focused on enhancing cardiac preparation in schools by establishing written emergency plans that are to be disseminated to employees within thirty days from the start of the school year. This web-based education tool was created as a centralized hub for employees to locate pertinent information regarding cardiac emergencies. The intent is to increase cardiac emergency preparedness in schools with access to evidence-based resources and content. The project began by performing a literature review to collect data on cardiac emergencies within the school, leading to the development of the web-based educational portal. The Cognitive Theory …

Associations Of Muscular And Cardiovascular Fitness Variables With Cardiovascular Disease In Older Adult Athlete Populations, Lauren T. Zick

Honors Thesis

This data analysis examined associations between cardiovascular and muscular fitness indicators and the presence of cardiovascular disease (CVD) in older adult athletes. Using cross-sectional data from 1,110 participants aged 50 and older who completed the Sustained Athlete Fitness Exam (SAFE) at state-level Senior Games events, we evaluated both objective performance metrics and self-reported exercise behaviors. Cardiovascular measures included systolic blood pressure (SBP), waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI). Muscular fitness was assessed through grip strength, maximum walking speed, and chair stand time. CVD status was defined as the presence of two or more self-reported cardiovascular …

A Clinical Review Of Suicide Risks In Dermatology, Rahib K. Islam, Victoria T. Tong, Shari R. Lipner

School of Medicine Faculty Publications

Patients with visible skin diseases, including acne, psoriasis, and atopic dermatitis, face heightened risks of psychological distress, depression, and suicidal ideation, often exacerbated by social stigma and reduced quality of life. This review explores the intersection between dermatology and suicide, highlighting the psychosocial impact of visible skin conditions and the controversies surrounding treatment-related risks, including isotretinoin and biologic exposure. Current evidence suggests that while isotretinoin has been historically linked to mood changes, robust studies do not support a direct association with suicide. Incorporating mental health screenings into dermatological practice is essential for early identification and management of at-risk patients. By …

Improving Staff Knowledge And Patient Care Outcomes Through Targeted Educational Interventions On Diabetes Management In Home Health Agencies, Chikita Domonique Smith

Walden Dissertations and Doctoral Studies

No abstract provided.

The Effect Of Recumbent Stepping On Leg Muscle Activity In Individuals With Multiple Sclerosis, Caroline Buchheit, Jack Castetter, Jessie Lakamp, Morgan Vollmer, Kurt Jackson

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: Recumbent steppers are commonly used for improving cardiovascular and muscular endurance in neurological populations. Prior research has shown that using specific verbal cues and a foot strap can significantly alter lower extremity muscle activity and recruitment in healthy individuals during recumbent stepping. The purpose of this case series was to measure lower extremity muscle activity during recumbent stepping under a variety of stepping conditions in persons with multiple sclerosis.

Number of Subjects: 3 adults (2 F, 1 M; age 40 -54) with multiple sclerosis (MS) with varying levels of lower extremity motor function and disability.

Materials and Methods: During …

The Relationship Between Dorsiflexion Mobility And Achilles Stiffness, Philip Anloague, Emma Collett, Sarah Monnier, Megan Garro, Tyler Stiers, Brandon Chan, Kendra Kahle, Hailey Mcpherson, Joaquin Barrios

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose: The biomechanical properties of muscles and tendons are important in rehabilitation and sport performance but are not routinely assessed. Recently, the MyotonPro device has been used in the assessment of a specific aspect of soft tissue stiffness, the resistance in deformation to an external force, at the Achilles tendon. Interestingly, it remains unclear if this stiffness is related to decreased ankle joint dorsiflexion mobility, and further if limb dominance affects this relationship. Indeed, dorsiflexion mobility has been linked to lower extremity injury risk such as anterior knee pain and anterior cruciate ligament injury. Therefore, the primary purpose of this …

Effects Of An Ehealth Program On Physical Performance In Women With Cancer-Related Fatigue And Breast Cancer, Sydney George, Kelsey Haas, Delaney Hardery, Catherine Nasman, Mary I. Fisher

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: Cancer-related fatigue (CRF) is common in women treated for breast cancer. Exercise can reduce CRF, yet the impact of an eHealth exercise program on physical performance (PP) is rarely described. While the primary aim was to reduce CRF, this ongoing study reports on the effect of an 8-week multidisciplinary physical (PT) and occupational therapy (OT) eHealth program on measures of PP.

Materials and Methods: Participants ages 18-69 diagnosed with breast cancer in the last 5 years, who rated fatigue ≥4/10 on 0-10 scale and had completed primary cancer treatment, were randomized to intervention (EX) or control (CON) groups. Using …

Concurrent Validation Of A Reverse Wall Lunge Test Position To Assess Hip Joint Extension Mobility, Joaquin Barrios, Anne Breeding, Hannah Dressman, Emily Howard, Justin Mitchell, Elizabeth Schueler, Lauren Thomas

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose: Hip joint extension mobility is commonly assessed for restriction in clinical practice, most often with the modified Thomas test (MTT). However, the MTT is not without challenges, particularly in regards to achieving and standardizing the proximal pelvis and trunk positioning. The lone 3D validation study on the MTT used a blood pressure cuff under the lumbar lordosis in an attempt to achieve standard positioning, which is not always clinically pragmatic. Therefore, we propose assessing hip extensibility with a novel reverse wall lunge test (RWL) described below, essentially as an upright weight-bearing version of the MTT that also standardizes proximal …

Determining The Concurrent And Predictive Validity Of The Repetitive Step Test In Individuals With Parkinson’S Disease, Harold Merriman, Kurt Jackson, Kathleen Mulligan, Arrah Sandy

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: The Repetitive Step Test (RST) assesses rapid stepping capability in anterior lateral (AL) and posterior lateral (PL) diagonal directions. This study’s goal was to determine the predictive validity of the RST to identify fallers with Parkinson’s Disease (PD). A secondary objective was to determine concurrent validity of the RST to other established tests. It was hypothesized that those who completed fewer steps with the RST would be more likely to fall and that the RST would predict falls at least as well as the other balance tests.

Materials and Methods: 19 subjects (10 F, 9 M; mean age 70.3 …

Soft Tissue Mobilization Is More Effective Than Self-Stretching In Reducing Common Wrist Extensor Tendon Stiffness In Recreational Tennis Players, Olivia Potts, Noah Knackstedt, Cayton Ruby, Harold Merriman, Joseph Day

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: Increased muscle and tendon stiffness plays a role in the development of musculoskeletal pathologies. A number of interventions have been proposed to temporarily reduce muscle/tendon stiffness including soft tissue mobilization (STM) techniques and stretching. The purpose of this study was to investigate the immediate and short-term effects of STM versus self-stretching on common extensor tendon (CET) stiffness in a group of recreational tennis players.

Subjects: Healthy recreational tennis players

Materials/Methods: Stiffness, measured with the shear wave modulus in kilopascals (kPa), was obtained at rest on the dominant CET using 2D ultrasound imaging shear wave elastography (SWE) (GE Logiq S8, …

A Criterion Reference Validity Study For The Modified Thomas Test For Hip Extension Mobility Using Three-Dimensional Motion Capture, Joaquin Barrios, Anne Breeding, Hannah Dressman, Emily Howard, Justin Mitchell, Elizabeth Schueler, Lauren Thomas

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose: Hip region extension mobility is commonly assessed in physical therapy practice, most commonly performed using the modified Thomas test (MTT). The validity of the MTT using 3D motion capture methods has been evaluated in only a study evaluating only healthy young males. Further, this study utilized a blood pressure cuff at 60 mm Hg under the lumbar lordosis to control the pelvis and trunk, further modifying the MTT and limiting clinical translation. Therefore, the purpose of this ongoing 3D motion capture study was to acquire criterion reference data for the traditional modified Thomas test without use of blood pressure …

Efficacy Of Abdominal Curl Up Task As Abdominal Exercise For Diastasis Recti Abdominis For Ehlers Danlos Syndrome, Julia Black, Ariana Bostwick, Sierra Darlington, Brooke Sizemore, Betsy Donahoe-Fillmore

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: Ehlers Danlos Syndrome (EDS) is a connective tissue disorder characterized by the inappropriate functioning and synthesis of collagen, elastin, and fibrillin in the body, affecting many systems including the musculoskeletal system. In hypermobility-type EDS, individuals can present with instability at various locations in the body and may result in joint dislocations and pain. This can result in difficulty activating the abdominal muscles. The purpose of this study is to determine if a focused 3 to 6 month rehabilitation program improves inter-rectus distance (IRD), abdominal strength, and body image in women diagnosed with EDS.

Number of Subjects: Women (n=24) 33-62 …