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Full-Text Articles in Medicine and Health Sciences

A Model For Teaching Social Determinants Of Health In Doctor Of Physical Therapy Programs, Elise N. Bjork, Rupal M. Patel Pt, Phd, Rebecca Operacz, Deandrea B. Melvey, Luciano Garcia Iii Jul 2025

A Model For Teaching Social Determinants Of Health In Doctor Of Physical Therapy Programs, Elise N. Bjork, Rupal M. Patel Pt, Phd, Rebecca Operacz, Deandrea B. Melvey, Luciano Garcia Iii

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to 1) describe the development and implementation of a novel educational module on social determinants of health (SDOH) for Doctor of Physical Therapy (DPT) students, and 2) to assess the effectiveness of the module on altering DPT students’ knowledge, attitudes, beliefs, and barriers in addressing SDOH. Methods: Drawing on current literature, content expert feedback, identity theory, and experiential learning theory, a two-hour module on SDOH was created and delivered at two universities. The Physical Therapy Social Determinants of Health Scale (PT-SDHS) was used to assess change in students’ knowledge, attitudes, beliefs, and barriers …


The Effect Of A Therapy Dog On Pressure Pain Threshold In Healthy Individuals, Lydia L. Haak, Rhonda L. Verdegan Jul 2025

The Effect Of A Therapy Dog On Pressure Pain Threshold In Healthy Individuals, Lydia L. Haak, Rhonda L. Verdegan

Internet Journal of Allied Health Sciences and Practice

Purpose: Pain is the most common reason for healthcare consultation in the United States. Pain affects every area of life; biologically, psychologically, and socially. These three constructs make up every individual and thus contribute to their perceived quality of life. The use of therapy dogs (TD) has been widely researched as a source of non-pharmacological pain management. Studies have proven that a dog can reduce perceived pain in people with a variety of comorbidities. The purpose of this study was to prove that pain is modulated biologically by dogs and not just by human perception. Methods: This was …


Virtual Lecture, Live Lecture, Flipped Classroom: Does Dpt Pain Curriculum Format Affect Student Pain Beliefs? A Preliminary Study, Jeb Helms, Jamie Ball, Kory J. Zimney Pt, Dpt, Phd Jul 2025

Virtual Lecture, Live Lecture, Flipped Classroom: Does Dpt Pain Curriculum Format Affect Student Pain Beliefs? A Preliminary Study, Jeb Helms, Jamie Ball, Kory J. Zimney Pt, Dpt, Phd

Internet Journal of Allied Health Sciences and Practice

Purpose: Currently there are multiple published examples of successful DPT delivery models for the International Association for the Study of Pain curricular guidelines. However, there are no direct comparisons between different IASP delivery models such as in-person vs hybrid or lecture vs flipped classroom. The purpose of this study was to compare 3 delivery formats for teaching a DPT pain science IASP based course (1. Virtual Lecture 2. In-person Lecture 3. Flipped in-person) for pre course and post course differences in student biomedical/biopsychosocial beliefs, and confidence to treat patients in pain.Method The instructors remained consistent throughout the study period, …


Enjoyment, Motivation, And Self-Efficacy Towards Physical Activity Among Physical Therapy Students, Lauren Butler, Amanda Thomas, Teresa Munecas, Erasmo Alvarez, David Capote, Alexa Almonte, Madeline Dawson, Jordan Hale, Mikayla Kerekes, Kaitlyn Mitchell, Mark D. Rossi Jul 2025

Enjoyment, Motivation, And Self-Efficacy Towards Physical Activity Among Physical Therapy Students, Lauren Butler, Amanda Thomas, Teresa Munecas, Erasmo Alvarez, David Capote, Alexa Almonte, Madeline Dawson, Jordan Hale, Mikayla Kerekes, Kaitlyn Mitchell, Mark D. Rossi

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to determine physical therapy (PT) students’ participation in and attitudes toward physical activity (PA).

Methods An electronic survey assessed demographic, academic, and sports history. Student’s PA level was assessed with the Godin Leisure-Time Exercise Questionnaire (Godin); PA enjoyment was assessed using the Physical Activity Enjoyment Scale (PACES); motivation was assessed using 4 items from the Modified Behavioral Regulation in Exercise (BREQ 3); and self-efficacy towards PA was assessed with the Exercise Self-Efficacy Scale (ESES). Descriptive statistics, Pearson correlations, and independent t-tests with 95% Confidence Interval (95% CI) were used.

Results In total, 228 …


Meeting Interprofessional Education Competencies Through A Multi-Scene Standardized Patient Simulation: A Pilot Study, Joanna Behm, Kristen Slabaugh, Karen Burket Jul 2025

Meeting Interprofessional Education Competencies Through A Multi-Scene Standardized Patient Simulation: A Pilot Study, Joanna Behm, Kristen Slabaugh, Karen Burket

Internet Journal of Allied Health Sciences and Practice

Purpose. Healthcare is increasingly delivered by teams of diverse disciplines. Interprofessional education for healthcare students is essential so that when students enter their respective fields, they come prepared with experience in interdisciplinary communication, teamwork, and communication. Accreditation and regulatory requirements for health professions programs have also increased the focus on interprofessional collaboration, requiring programs to be creative in finding effective and efficient integration methods. The purpose of this pilot study was to identify the perceived impact of an interprofessional collaboration event on enhancing students’ interprofessional education competency attainment. Methods. An interprofessional collaboration committee created a multi-scene, unfolding case study …


Understanding The Relationship Between Occupation And Cognitive Abilities: A Preliminary Study, Deepak Puttanna, Srinidhi Konda, Mohammed Al Harbi Jul 2025

Understanding The Relationship Between Occupation And Cognitive Abilities: A Preliminary Study, Deepak Puttanna, Srinidhi Konda, Mohammed Al Harbi

Internet Journal of Allied Health Sciences and Practice

Purpose: Understanding the cognitive abilities across various occupational backgrounds is deemed crucial, owing to the fact that the cognitive load imposed in each of the roles varies, thus there may be different levels of cognitive skills used in daily day-to-day activities. Also, it paves the way for the researchers to understand how an intellectually stimulating environment aids in better cognitive reserve or hinders cognitive decline. Method: A total of 60 participants aged between 30 to 50 years participated in the study. These participants were further divided into two broad groups, professional/technical workers and structural work occupations. These occupations were …


Maximizing Relief: The Benefits Of Combining Lateral Femoral Cutaneous Nerve Block With Sciatic Nerve Block In The Emergency Department, Courtney Smith, Taryn Hoffman Jul 2025

Maximizing Relief: The Benefits Of Combining Lateral Femoral Cutaneous Nerve Block With Sciatic Nerve Block In The Emergency Department, Courtney Smith, Taryn Hoffman

Florida Journal of Emergency Medicine (FJEM)

Low back pain accounts for more than 2.6 million emergency department (ED) visits annually, with 40% of Americans experiencing sciatica at some point in their lives. Our case report describes a patient presenting with atraumatic right-sided low back pain and paresthesias in her right leg. We utilized a combination of a transgluteal sciatic nerve block and a lateral femoral cutaneous nerve block to achieve improved pain relief after an initial isolated transgluteal sciatic nerve block left her with persistent anterolateral thigh pain.

We detail the technique for performing this procedure under ultrasound guidance. Our patient experienced significant pain improvement and …


"Star Sign" Of Subarachnoid Hemorrhage, Shivani Ruf Jul 2025

"Star Sign" Of Subarachnoid Hemorrhage, Shivani Ruf

Florida Journal of Emergency Medicine (FJEM)

A 60-year-old female who was brought to the emergency department after a syncopal episode. She was found to have a subarachnoid hemorrhage (SAH) from a ruptured anterior communicating artery aneurysm. Her CT showed the classic "star sign" of SAH.


Elderly Woman With Bilateral Finger Pain, Eric Boccio, Claudia Risi Jul 2025

Elderly Woman With Bilateral Finger Pain, Eric Boccio, Claudia Risi

Florida Journal of Emergency Medicine (FJEM)

N/A


Paroxysmal, Severe, And Unilateral Facial Pain In Adult Male, Eric Boccio, Joshua Mcfarlane, Jeannine Bobadilla Jul 2025

Paroxysmal, Severe, And Unilateral Facial Pain In Adult Male, Eric Boccio, Joshua Mcfarlane, Jeannine Bobadilla

Florida Journal of Emergency Medicine (FJEM)

No abstract provided.


Intouch Week Of July 28, 2025, New York Medical College Jul 2025

Fathers Using Light Touch On Their Infants And Its Effects On Postnatal Paternal Depression, Christopher Dirkes Jul 2025

Fathers Using Light Touch On Their Infants And Its Effects On Postnatal Paternal Depression, Christopher Dirkes

DNP Projects

Background:
During the postpartum period there are multiple resources available to address maternal postpartum depression. However, there are limited resources available to help fathers during this transition period. Currently, limited data is available for best practice to decrease postnatal paternal depression, and increase paternal bonding and comfortability when caring for the infant.

Method:
Fathers were recruited from a Midwestern Public Health Department. After recruitment, fathers were provided with in-home education on how to perform a light touch intervention. Pre-intervention qualitative and quantitative surveys were provided at this time. Fathers were then asked to record their emotions as well as infant …


Use Of A Shoulder-Mounted Wearable Sensor Prototype Designed To Detect Opioid-Related Overdose: A Qualitative User Experience Study, Alexis M. Roth, Ally K. D'Angelo, David Gordon, Benjamin Cocchiaro, Anush Lingamoorthy, Rose Laurano, Matthew Salzman, Jacob S. Brenner, Cameron Baston Jul 2025

Use Of A Shoulder-Mounted Wearable Sensor Prototype Designed To Detect Opioid-Related Overdose: A Qualitative User Experience Study, Alexis M. Roth, Ally K. D'Angelo, David Gordon, Benjamin Cocchiaro, Anush Lingamoorthy, Rose Laurano, Matthew Salzman, Jacob S. Brenner, Cameron Baston

SKMC Student Presentations and Publications

BACKGROUND: For over a decade, drug overdose has been the leading cause of injury and accidental death in the United States. Most fatal overdoses involve opioids and occur during solitary drug use events when no one is available to initiate lifesaving responses (eg, naloxone). While there is a growing interest in devices providing early overdose detection and automated responses, little research has engaged end users in a device design process.

OBJECTIVE: This study aimed to describe user experience, perceived harms and benefits, and the acceptability of a shoulder-mounted wearable sensor among people who inject drugs who wore a device prototype …


Implementation Of Intimate Partner Violence Education To Improve Practice And Attitude Amongst Healthcare Providers, Abigail Nguyen, Breanna Carpenter Jul 2025

Implementation Of Intimate Partner Violence Education To Improve Practice And Attitude Amongst Healthcare Providers, Abigail Nguyen, Breanna Carpenter

DNP Projects

Background
Intimate partner violence (IPV) is a serious and costly public health issue. It is vital that patients are screened at least annually for intimate partner violence. Screening increases disclosure of abuse and allows primary care clinicians to provide comfort, education, and resources to patients experiencing IPV. Evidence strongly suggests that a major barrier to regular screening for IPV is a lack of knowledge and comfort amongst healthcare providers.

Purpose
This project’s purpose was to provide educational tools for healthcare providers related to the importance of screening for IPV, guidelines for most effective screening, common IPV misconceptions, and local resources. …


The Impact Of Non-Athletic, Flat-Soled Sneakers On Gait Kinematics: A Comparative Analysis With Socks, Aaron Aguilar, Kharen Bautista, Juan Claros, Raquel Dimaano, Ciara Franke, Mason Huber, Evan Kurishige, Anton Lam, Kevin Le, Alohi Sheung, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra Jul 2025

The Impact Of Non-Athletic, Flat-Soled Sneakers On Gait Kinematics: A Comparative Analysis With Socks, Aaron Aguilar, Kharen Bautista, Juan Claros, Raquel Dimaano, Ciara Franke, Mason Huber, Evan Kurishige, Anton Lam, Kevin Le, Alohi Sheung, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra

Physical Therapy Faculty Articles and Research

This study investigates the kinematic effects of non-athletic, flat-soled sneakers on lower extremity joints during walking. Ten healthy gym-goers (24.4 ± 1.7 years) underwent treadmill gait analysis under two conditions: wearing non-athletic sneakers and walking with only socks. Gait was captured using the Gait Real-time Analysis and Interactive Lab (GRAIL). Dependent variables included cadence, support times, and stride length. Walking with socks significantly increased cadence (p <  .0001) and single support time (p = .0103), and decreased initial (p = .018), terminal (p = .0056), and total double support times (p = .0092). No significant difference in stride length was observed. These …


Table Of Contents Jul 2025

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Metabolic Consequences Of Sleep Disorders: A Comprehensive Analysis Of Their Role In Diabetes, Victoria S. Parma Jul 2025

Metabolic Consequences Of Sleep Disorders: A Comprehensive Analysis Of Their Role In Diabetes, Victoria S. Parma

Journal of the South Carolina Academy of Science

The prevalence of type 2 diabetes continues to grow globally, and more strategies are needed to combat this public health problem. Considering the link between sleep problems and risk of type 2 diabetes, the objective of this review is to discuss the experimental and epidemiological evidence underlying the link between sleep disturbances (such as insomnia, circadian rhythm disorders, and obstructive sleep apnea), and the development of insulin resistance and glucose intolerance, which are impairments that can eventually result in type 2 diabetes. In order to explore this, PubMed and Google Scholar were utilized to find pertinent peer-reviewed publications, reviews, and …


Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden Jul 2025

Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden

Masters Projects

This study evaluated the impact of Pinnacle³ version 18.0 auto-planning advanced settings modulation amount, monitor unit (MU) level, and dose fall-off priority on volumetric modulated arc therapy (VMAT) plan quality for bilateral oropharyngeal cancer. A total of 64 plans were generated using all possible combinations of low, medium, high, and very high settings for each parameter. A standardized base of tongue case was optimized once per plan using a single-time point approach, with planned target volume 1 (PTV1) (6996 cGy) and planned target volume 2 (PTV2) (5412 cGy) coverage evaluated. Each parotid gland, the spinal cord, brainstem, and the oral …


07.28.2025 Ored Connect, Liz Williamson Jul 2025

07.28.2025 Ored Connect, Liz Williamson

ORED Newsletter

On-demand training courses released

  • Mentoring
  • My Project Was Funded, Now What?

Notice of Funding Opportunity SMART Act Accelerate Initiative

Memo Regarding Contact from Federal Agencies


Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco Jul 2025

Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco

Walden Dissertations and Doctoral Studies

The increasing prevalence of obesity and mental health disparities among Hispanic/Latino populations in the United States underscores the need to understand how sociocultural factors shape physical and psychological health. The purpose of this study was to examine how acculturation, diet quality, and fiber intake affect BMI and depressive symptoms over time. The study was guided by acculturation theory and the biopsychosocial model. The study used longitudinal secondary data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with a sample of N=8,816, including adults who completed examination visits, 1 (2008–2011) and 2 (2014–2017). Path analysis was conducted to assess direct …


Explore Toolkit, Kimberly Page, Janet Page Reeves, Ivan De La Rosa, Marie Alice Scott, Christina Phillips, Maria Sanchez, Andrew Gorvetzian, Joe Albright, Cynthia Killough, Randall Benalli Jul 2025

Explore Toolkit, Kimberly Page, Janet Page Reeves, Ivan De La Rosa, Marie Alice Scott, Christina Phillips, Maria Sanchez, Andrew Gorvetzian, Joe Albright, Cynthia Killough, Randall Benalli

Epidemiology, Biostatistics, and Preventive Medicine

Welcome to the Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (EXPLORE) Toolkit, a resource designed to support researchers and frontline workers addressing substance use in the Borderlands. The EXPLORE Toolkit was designed by an interdisciplinary team of epidemiologists, social workers, anthropologists, and public health professionals to enhance the engagement of underrepresented communities in substance use clinical trials. Utilizing a strength-based approach, the toolkit addresses equity, stigma, and participation barriers, promoting culturally sensitive and community-centered research practices. This toolkit is an ideal tool for clinical trials researchers and community health workers who are interested in learning more …


Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh Jul 2025

Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh

Faculty Scholarship

Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. Herein, a subcutaneous formulation based on polymer of alpha-ketoglutarate (paKG) delivering glycolytic inhibitor PFK15 (PFKFB3 inhibitor, a rate limiting step in glycolysis), alpha-ketoglutarate (to fuel Krebs cycle) and peptide antigen from myelin proteolipid protein (PLP139-151) is utilized as the prophylactic immunosuppressive formulation in a mouse model of TBI. In vitro, the paKG(PFK15+PLP) formulation stimulates proliferation of immunosuppressive regulatory …


Superficial Cervical Plexus Block For Postoperative Pain Management In Occipital Craniotomies: A Narrative Review, Shahab Ahmadzadeh, Bennett M. Ford, Alex V. Hollander, Mary Kathleen Luetkemeier, Tomasina Q. Parker-Actlis, Sahar Shekoohi Jul 2025

Superficial Cervical Plexus Block For Postoperative Pain Management In Occipital Craniotomies: A Narrative Review, Shahab Ahmadzadeh, Bennett M. Ford, Alex V. Hollander, Mary Kathleen Luetkemeier, Tomasina Q. Parker-Actlis, Sahar Shekoohi

School of Medicine Faculty Publications

Post-craniotomy pain is common yet often sub-optimally managed because systemic opioids can obscure postoperative neurologic examinations. The superficial cervical plexus block (SCPB) has, therefore, emerged as a targeted regional anesthesia option for occipital craniotomies. The SCPB targets the C2-C4 nerves to anesthetize the occipital scalp region, covering the lesser occipital nerve territory that lies within typical posterior scalp incisions. Clinical evidence shows the block is effective in reducing acute postoperative pain after occipital craniotomy and diminishes opioid requirements. Studies have demonstrated successful and long-lasting analgesia, reductions in 24-h opioid consumption, and a lower incidence of severe pain. Moreover, the technique …


Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma Jul 2025

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemotherapeutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor sites. …


Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma Jul 2025

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

College of Pharmacy Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemothera- peutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor …


A Novel Microdosimetry-Based Formalism For Cell Survival Modelling Applicable To Hypofractionated Radiotherapy, Oleg N Vassiliev, Radhe Mohan Jul 2025

A Novel Microdosimetry-Based Formalism For Cell Survival Modelling Applicable To Hypofractionated Radiotherapy, Oleg N Vassiliev, Radhe Mohan

Faculty, Staff and Student Publications

Objectives

Hypofractionated radiotherapy requires reliable cell survival models for doses much higher than the standard 2 Gy, for which the linear-quadratic (LQ) model is not applicable. We developed an alternative approach applicable to both low doses and high doses used in hypofractionated treatments and radiobiological experiments.

Approach.

We combined a standard microdosimetric technique with a recently introduced non-LQ cell survival model. Our formulation accounts for cell damage by multi-track events involving any number of particles. This is necessary for modelling cell survival at therapeutic doses. We characterise each cell type by the size �� of the sensitive volume (SV) and …


Use Of Cholic Acid In Smith-Lemli-Opitz Syndrome (Slos): Real-World Patient Outcomes, Edwin Ferren, Paul R Hillman, Amy Kritzer, Joseph Ray, Alvaro Serrano, Hope Northrup, Paige Roberts, Rana Dutta, Tiziano Pramparo, Pamela Vig, Robert D Steiner Jul 2025

Use Of Cholic Acid In Smith-Lemli-Opitz Syndrome (Slos): Real-World Patient Outcomes, Edwin Ferren, Paul R Hillman, Amy Kritzer, Joseph Ray, Alvaro Serrano, Hope Northrup, Paige Roberts, Rana Dutta, Tiziano Pramparo, Pamela Vig, Robert D Steiner

Faculty, Staff and Student Publications

Background: Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive disorder of cholesterol biosynthesis caused by biallelic pathogenic variants in DHCR7, which encodes the enzyme 7-dehydrocholesterol reductase (DHCR7). SLOS is a multisystemic disorder affecting various aspects of health, including growth, development, behavior, and quality of life, underscoring the need for safe, efficacious interventions that limit disease burden. DHCR7 enzyme deficiency leads to a "metabolic block" resulting in decreased cholesterol production and accumulation of its precursor 7-dehydrocholesterol and the secondary isomer 8-dehydrocholesterol. Reduced cholesterol synthesis, in turn, leads to decreased levels of cholic acid (CA), an endogenous bile acid synthesized from cholesterol and …


Melanoma Antigens In Pediatric Medulloblastoma Contribute To Tumor Heterogeneity And Species-Specificity Of Group 3 Tumors, Rebecca R J Collins, Rebecca R Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K Lee, Samuel T Peters, Jon P Connelly, Shondra M Pruett-Miller, Martine F Roussel, Dinesh Rakheja, Heather S Tillman, Patrick Ryan Potts, Klementina Fon Tacer Jul 2025

Melanoma Antigens In Pediatric Medulloblastoma Contribute To Tumor Heterogeneity And Species-Specificity Of Group 3 Tumors, Rebecca R J Collins, Rebecca R Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K Lee, Samuel T Peters, Jon P Connelly, Shondra M Pruett-Miller, Martine F Roussel, Dinesh Rakheja, Heather S Tillman, Patrick Ryan Potts, Klementina Fon Tacer

Faculty, Staff and Student Publications

Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB (G3 MB) subtype accounts for about 25% of MB and is associated with the worst outcomes. Herein, we report that more than half of G3 MB tumors express melanoma antigens (MAGEs), which are potential prognostic and therapeutic markers. MAGEs are cancer-testis antigens, aberrantly expressed in several adult cancers, and associated with poorer prognosis and therapy resistance; however, their role in pediatric cancers is mostly unknown. This study aimed to determine whether MAGEs are activated and important in pediatric MB. We obtained formalin-fixed paraffin-embedded tumor samples of 34 patients, …


Effectiveness Of Vaginal Magnesium Sulfate On Pain And Labor Duration: A Systematic Review And Meta-Analysis, Somayeh Makvandi, Elham Manouchehri, Mahdieh Razi, Samaneh Alinejad Mofrad, Mona Larki Jul 2025

Effectiveness Of Vaginal Magnesium Sulfate On Pain And Labor Duration: A Systematic Review And Meta-Analysis, Somayeh Makvandi, Elham Manouchehri, Mahdieh Razi, Samaneh Alinejad Mofrad, Mona Larki

Sultan Qaboos University Medical Journal

This systematic review and meta-analysis aimed to evaluate the effectiveness of vaginal magnesium sulfate (MgSO4) administration during labour. A comprehensive search was conducted across six databases up to 30 July 2024, and updated on 13 January 2025, with no restrictions on time, language, or geographical region. The risk of bias was assessed using the RoB 2 tool, and the certainty of evidence was evaluated using GRADEpro. A total of seven randomised controlled trials were included. The meta-analysis demonstrated that topical magnesium sulfate significantly increased cervical dilatation by 2.27 cm (95% confidence interval [CI]: 1.98 to 2.56; PPP


The 18s Rrna Methyltransferase Dimt-1 Regulates Lifespan In The Germline Later In Life, M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad, Wayne Mitchell, Kejun Ying, Nancy Pohl, Roberto G Sotomayor-Mena, Julia Natale, Scarlett Dellacona, Vadim N Gladyshev, Eric Lieberman Greer Jul 2025

The 18s Rrna Methyltransferase Dimt-1 Regulates Lifespan In The Germline Later In Life, M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad, Wayne Mitchell, Kejun Ying, Nancy Pohl, Roberto G Sotomayor-Mena, Julia Natale, Scarlett Dellacona, Vadim N Gladyshev, Eric Lieberman Greer

2020-Current year OA Pubs

Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m