Medicine and Health Sciences Commons^™

Hyperglycemia And Oral Health: A Review Of Dental Clinicians’ Perceptions And Practices Of Blood Glucose Monitoring In The Dental Office, Kathleen Wozniak

Dental Hygiene ETDs

This study aims to review the current practices and perceptions of dentists regarding the likelihood of dental professionals incorporating blood glucose monitoring into patient care protocol of patients with diabetes mellitus and prediabetes in dental offices. A survey link was shared by DentalOffices, a dental resource center. The survey included a series of questions which aimed to review dentists' current attitudes, practices, and considerations for implementation of in-office blood glucose testing as it relates to the treatment of patients with diabetes mellitus. Forty-seven dentists participated in the survey. This study determined blood glucose testing is not a common protocol or …

A Mutational Analysis Of Thatisin: How Single Point Mutations Impact The Biosynthetic Process Of A Group 16 Graspetide, John F. Boynton Jr

Chemistry and Chemical Biology ETDs

Abstract:

Graspetides are a family of Ribosomally synthesized and Post-translationally modified Peptide (RiPP) natural products named for their ATP Grasp Macrocyclases. We identified several Graspetide Biosynthetic Gene Clusters containing common double glycine cleavage motifs and attempted characterization of the mature Graspetides. One of the resulting peptides, Thatisin, has a topology with two interlocking macrolactones installed by a single ATP Grasp Ligase named ThtC. Here we use single and double point mutations to observe the impact or variation on the installation of these macrocycles. Alanine scan mutagenesis is used to assess leader peptide residues in the precursor peptide ThtA to determine …

Resilience Mediates The Association Between Discrimination And Psychological Distress Among Rural, Black Women In South Carolina: A Structural Equation Model, Camryn Garrett, Abhisheak Aggrawal, Huiyi Xia, Cheuk Chi Tam, Bankole Olatosi Ph.D., Sarah Wilcox Phd, Xiaoming Li Ph.D., Shan Qiao Ph.D.

Faculty Publications

Introduction

The marginalization of intersecting racial, gender, and rural identities compounds the structural vulnerabilities (e.g., discrimination, stigma, health disparities) experienced by Black women in South Carolina’s rural areas. Discriminatory experiences can deteriorate mental health; however, resilience can potentially reduce the ill effects of discrimination by decreasing associated psychological distress. This study examines the mediating role of resilience in the association between discrimination and psychological distress among rural, Black women in South Carolina in the post-pandemic era.

Methods

Black women (n = 300, mean age = 48.6) living in rural South Carolina were recruited from January to February 2024 using …

Transforming Cancer Care: A Narrative Review On Leveraging Artificial Intelligence To Advance Immunotherapy In Underserved Communities, Victor M. Vasquez Jr., Molly Mccabe, Jack C. Mckee, Sharon Siby, Usman Hussain, Farah Faizuddin, Aadil Sheikh, Subramanian Dhandayuthapani, Shrikanth Gadad, Jessica Chacon

School of Medicine Publications

Purpose: Cancer immunotherapy has transformed oncology, but underserved populations face persistent disparities in access and outcomes. This review explores how artificial intelligence (AI) can help mitigate these barriers. Methods: We conducted a narrative review based on peer-reviewed literature selected for relevance to artificial intelligence, cancer immunotherapy, and healthcare challenges, without restrictions on publication date. We searched three major electronic databases: PubMed, IEEE Xplore, and arXiv, covering both biomedical and computational literature. The search included publications from January 2015 through April 2024 to capture contemporary developments in AI and cancer immunotherapy. Results: AI tools such as machine learning, …

Single-Nuclei Multiomics Analysis Identifies Abnormal Cardiomyocytes In A Murine Model Of Cardiac Development., Riley Leonard, Yi Zhao, Steven Eliason, Kathy Zimmerman, Ariana Batz, Cathy J. Hatcher, Robert M Weiss, Mason Sweat, Xiao Li, Brad A Amendt

PCOM Scholarly Works

Transcription factors such as Tbx5, Gata4, Mef2c and Pitx2 are required during cardiac development, and in adult cardiac homeostasis. We demonstrate that the gene dosage and modulation of these factors are mediated in vivo by the miR-200 family. Inhibition of a single miR-200 family member within the cluster results in defects of the left ventricle and cardiomyocyte maturation during development. Inhibition of the entire miR-200 family results in a ventricular septal defect and embryonic lethality by embryonic day (E)16.5. Inhibition of each miR-200 family has distinct heart phenotypes in cell specific differentiation and maturation. snRNA-sequencing reveals an immature cardiomyocyte cell …

Staff Education To Increase The Number Of Continuous Glucose Monitors (Cgms) Prescribed At An Adult Primary Care Clinic For Individuals With Type 2 Diabetes., Josephine Opara

Walden Dissertations and Doctoral Studies

This quality improvement project focused on increasing the use of continuous glucose monitors (CGMs) in primary care for patients with type 2 diabetes. Its goal was to enhance providers' ability to prescribe and manage CGMs effectively. A review of existing literature and a provider survey identified key barriers, such as limited time and insufficient provider education on CGMs. The survey emphasized educational needs related to initiating and prescribing CGMs. Educational materials, including a PowerPoint presentation on prescribing, monitoring, and management, were developed and shared with clinic staff. Consequently, CGM prescriptions increased over the three-month period. The project aimed to improve …

Effects Of Neoadjuvant Immunotherapy On Hearing In Patients With Head And Neck Squamous Cell Carcinoma, Bryce Hambach, Anhelina Bilokon, John Lee, L. Noelle Allemang, Jennifer Chisholm, Chris K. Zalewski, Julie Christensen, Carmen C. Brewer, James L. Gulley, Clint T. Allen, Lisa L. Cunningham, Katharine A. Fernandez

SKMC Student Presentations and Publications

Immune checkpoint blockade (ICB) is a commonly used treatment modality for cancer with a growing list of oncologic indications. Ototoxicity is a potential immune-related adverse event of ICB treatment, but the risk of hearing loss after ICB remains unknown. This retrospective chart review sought to identify individuals who received ICB and had available audiometric data before and after treatment in order to identify clinically meaningful changes in hearing. This single center, institutional chart review examined hearing function data in patients who underwent audiometry before and after ICB treatment. Measures included pure tone thresholds, distortion product otoacoustic emissions (DPOAEs), tympanometry, and …

Scoping Review: Faktor – Faktor Yang Mempengaruhi Keputusan Lansia Memilih Senior Living, Nia Murniati, Badra Al Aufa, Mochamad Iqbal Nurmansyah

Jurnal Administrasi Bisnis Terapan

Abstract Senior living has emerged as an alternative solution to public health and social policy challenges amid the global acceleration of aging. Traditionally perceived as a last resort, life in senior living facilities is shaped by evolving dynamics in health, family, and society. This scoping review explores the key factors influencing older adults' decisions to reside in senior living communities during their later years. Utilizing Andersen’s Behavioral Model of Health Service Use as a theoretical framework, the review was conducted following PRISMA-ScR guidelines. Articles published between 2019 and 2024 were identified through searches in PubMed, Scopus, ProQuest, and Taylor & …

Refinement Of Hyams Grading Criteria For Olfactory Neuroblastoma In An Endoscopic Sinus Surgery Predominant Cohort With Extended Follow-Up: Worth The Effort?, Stacey Gargano, Vincent Cracolici, Carl Snyderman, Eric Wang, Garret Choby, Aron Pollack, Paul Gardner, Diana Bell, Raja Seethala

Computational Medicine Center Faculty Papers

BACKGROUND: Hyams grading is considered prognostic in olfactory neuroblastoma (ONB), but grading criteria are subjective and predate modern classification and surgical approach. We evaluate the application of granular grading criteria to an endoscopic surgery predominant cohort with extended follow-up.

METHODS: 78 ONB patients were identified (1994-2019) with original diagnoses dating to 1979. Original Hyams grade, Modified Hyams grade incorporating more detailed criteria and other histologic features (i.e. divergent differentiation, clear cell/oncocytic change, and spindling) were assessed if feasible, evaluated for distribution by grade and correlated with outcomes.

RESULTS: Original Hyams grade (n = 43) distribution was: I: 4 (9%), II: …

Inequality And Covid Risk At School: Racial Disparities In Indoor Density, Vaccination Rates, And Consequences For Absenteeism, Michael C. Quinn, Michah W. Rothbart, Amy Ellen Schwartz, Brian Elbel

Center for Policy Research

During the COVID pandemic, schools were widely believed to be a venue that facilitated disease transmission. While some worried Black and Hispanic students would disproportionately face greater risk of COVID exposure at school (school COVID risk) – given well-documented racially disparate school environments and resources – little empirical evidence exists documenting or refuting potential disparities in school COVID risk. This paper begins to fill this gap by examining racial disparities in the school environments that contribute to COVID risk at school—specifically, vaccination rates and classroom space per pupil (indoor density) - in New York City elementary schools. We then document …

Potential Of Legume Seeds From The Leguminosae Family As Material Source Of Food And Medicine : A Literature Review, Ni Made Ayu Gangga Dewi, Nina Dewi Oktaviyanti, Aurapa Sakulpanich, Kartini Kartini

Pharmaceutical Sciences and Research

Leguminosae, also known as Fabaceae, is the third largest plant family after Orchidaceae and Asteraceae. This review aimed to explore the potential of several legume species indigenous to Indonesia, from the Leguminosae family, as sources of food and medicine. The data used for the analysis were collected from various online databases such as PubMed, ScienceDirect, and Google Scholar. The results showed that there were 13 species of Leguminosae family plants found easily in Indonesia including Cajanus cajan, Canavalia ensiformis, Mucuna pruriens, Arachis hypogaea, Vigna subterranea, Glycine max, Phaseolus vulgaris, Phaseolus lunatus, Vigna radiata, Vigna unguiculata subsp. unguiculata, Vigna angularis, Vigna …

Microneedle-Based Lc-Ms/Ms Profiling Of Dermal Interstitial Fluid Reveals Early Lipid Dysregulation Contributing To Painful Neuropathy In Prediabetic And Type 2 Diabetic Rats, Srinivasa Rao Gadam

Biomedical Sciences ETDs

Painful diabetic neuropathy (PDN), a complication of type 1 and type 2 diabetes, also occurs in obesity and prediabetes, with dyslipidemia as a modifiable risk factor. The distal-to-proximal neuropathy pattern and length-dependent intraepidermal nerve fiber loss suggest peripheral contributions. We hypothesized that elevated neurotoxic lipid intermediates—diacylglycerols (DAG), free fatty acids (FFA), and acylcarnitines (CARs)—in the dermal interstitial fluid (ISF) drive metabolism-associated hyperalgesia in prediabetic and diabetic rats. Using a microneedle array (MIA) with LC-MS/MS, we profiled ISF and serum lipids from high-fat diet (HFD) and HFD + streptozotocin (STZ) rat models alongside Hargreaves testing. ISF lipid changes appeared earlier (weeks …

Exploration, Expansion, And Optimization Of Bacteriophage Virus-Like Particle Vaccines, Andzoa N. Jamus

Biomedical Sciences ETDs

Bacteriophage virus-like particles are highly immunogenic, self-assembling platforms used for various vaccines. This work shows efforts to explore new vaccine candidates against Chlamydia trachomatis, targeting proteins that play critical roles in attachment and entry into the host cell, as well as in pathogenesis and bacteria proliferation. This work also shows the optimization of previously identified candidates, by investigating how altering routes of immunization can change the antibody profiles elicited, both systemically and locally. Finally, this work shows the establishment of various Chlamydia infection models in an effort to expand the ways in which vaccine efficacy can be investigated, particularly …

Immune Regulation In Fungal Airway Inflammation And Host Defense, Ruoning Wang

Biomedical Sciences ETDs

Asthma is a chronic inflammatory disease of the lungs characterized by complex pathophysiological mechanisms and diverse endotypes, primarily categorized as T helper type 2 cell (Th2)-high and Th2-low asthma. Despite significant advances in understanding asthma pathogenesis, the mechanisms governing the pulmonary immune system’s response to external challenges have not been fully understood. To address these gaps, this comprehensive project was designed to investigate the interplay between fungal infections and specific CD4⁺ T cell populations in asthma. Our findings suggest that fungal infections can contribute to neutrophilic asthma by promoting the migration of platelet-myeloid aggregates into the lungs. We also …

Localization Of Alpha Power Deficits In First Episode Psychosis, Crystal A. Garcia, Juan Bustillo

Biomedical Sciences ETDs

The purpose of this study was to determine where in the brain there may be a difference in brain activity in patients during their first episode of psychosis (FEP) compared to healthy controls (HCs) while performing an auditory oddball task. Time-frequency analysis allows for spectral decomposition where the signal measured by magnetoencephalography (MEG) is used to characterize changes in neural oscillations and their synchronization over time and region. Previous EEG studies report reduced alpha (8-12Hz, 70-160ms) power but most studies focused on patients with chronic schizophrenia and with limited source localization.

Elizabethkingia Infections - An Important Emerging Cause Of Sepsis And Meningitis In Neonates And Infants: Case Series From North Batinah Region, Oman, And Literature Review, Mohammed Said Al Reesi, Latifa Abdullah Al Muttawa, Mariam Abdullah Albolushi, Naima Salim Al Risi

Sultan Qaboos University Medical Journal

Elizabethkingia species, particularly E. anophelis and E. meningoseptica, are gram negative bacilli known to be associated with neonatal infections. Although these bacteria are rare, they are highly concerning pathogens associated with severe sepsis, bacteraemia and meningitis in neonates and immunocompromised individuals. Managing Elizabethkingia infections presents significant challenges because of their multidrug resistance, including resistance to most β-lactam agents. They have been implicated in both nosocomial and community outbreaks worldwide, often with high mortality rates. In Oman, Elizabethkingia infections are underreported, with only 1 publication documenting 2 cases of E. meningoseptica bacteraemia and meningitis, both of which were successfully …

An Analysis Of Employment Patterns And Career Decisions Among Dental Hygienists: In A Transforming Healthcare Landscape, Shirley Calderon Jamarck

Dental Hygiene ETDs

The purpose of this study was to identify the factors contributing to dental hygienists’ consideration of changing careers, retiring early, or feeling burned out. A 26-question survey was emailed to members of the American Dental Hygienists’ Association, with 742 responses meeting inclusion criteria. Participants evaluated aspects of their careers, including job satisfaction, wages and benefits, personal growth, work-related stress, burnout, work-life balance, and retirement plans. Results revealed that one-third of respondents planned to leave the profession, citing burnout, physical strain, and limited career growth as reasons. High correlations were found between job satisfaction and feeling valued, professional accomplishment, and growth …

Gallic, Aconitic, And Crocetin Acids As Potential Tnf Modulators: An Integrated Study Combining Molecular Docking, Dynamics Simulations, Admet Profiling, And Gene Expression Analysis, Adolat Manakbayeva, Ahdrey P. Bogoyavlenskiy, Timur Kerimov, Igor Yershov, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Vyacheslav Dushenkov

Publications and Research

Organic acids, as natural metabolites, play crucial roles in human metabolism and health. Tumor Necrosis Factor (TNF), a pivotal mediator in immune regulation and inflammation, is a key therapeutic target. We evaluated ten organic acids as TNF modulators using in silico molecular docking, followed by detailed ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling and molecular dynamics (MD) simulations for three lead candidates: gallic, aconitic, and crocetin acids. Their effects on TNF gene expression were then assessed in vivo using a mouse leukocyte model. The in silico results indicated that crocetin had the highest TNF binding affinity (−5.6 to −4.6 …

Assessing The Effects Of Antibiotic Selectivity And Temperature On The Antimicrobial Activity Of Isolates Derived From The Deep-Sea Sponge Pheronema Capenteri, Lex L. Hilario

The Plymouth Student Scientist

The rapid increase of antibiotic resistance necessitates the discovery of novel antibiotic compounds capable to tackle these resistant bacteria. Deep-sea sponges accommodate a diverse and dense microbiome filled with an array of bacterial communities that have the potential to produce novel antimicrobials. Some discovered novel strains have already shown their capability in producing secondary metabolites that are effective against clinically relevant strains. This study aims to evaluate the impacts of different culture conditions; antibiotic selectivity and temperature, on the antimicrobial activity of isolates recovered from three different Pheronema carpenteri deep-sea sponges. Using culture-dependant methods, a total of 59 bacterial isolates …

Comparing P62 And Lc3 As Autophagy Biomarkers: Insights Into Cellular Homeostasis, Riya Roychan

The Plymouth Student Scientist

Autophagy is a fundamental cellular process that maintains homeostasis by the degradation of damaged organelles and proteins. It plays crucial roles in cellular remodelling, development, and disease progression. These roles apply to the study of neurodegenerative diseases which is heavily linked to the toxicity produced by unwarranted accumulation of cellular material. A key player in autophagy is LC3, which translocate to autophagosomal membranes during the process. Detecting fluorescently labelled LC3-II through immunofluorescence provides a valuable method for assessing autophagy levels in samples. In a similar premise p62, also known as sequestosome-1 (SQSTM-1), is an adaptor between LC3 and ubiquitinated substrates, …

Clinician And Caregiver Perspectives On A Community-Based Dynamic Temporal And Tactile Cueing Treatment Trial For Childhood Apraxia Of Speech: Exploring Perceptions Of Research And Routine Clinical Practice, Donna C. Thomas, Geraldine Bricker-Katz, Elizabeth Murray, Shelley L. Velleman, Jenya Iuzzini-Seigel

Speech Pathology and Audiology Faculty Research and Publications

Purpose:

Dynamic Temporal and Tactile Cueing (DTTC) is an evidence-based treatment for children with childhood apraxia of speech. In clinical practice, speech-language pathologists (SLPs) frequently use an eclectic approach incorporating aspects of DTTC, for reasons that are not well understood. This research note describes a qualitative investigation of the experiences of SLPs and caregivers who participated in protocolized research DTTC for a 24-session treatment efficacy study. Specifically, we sought to understand the perspectives of these SLPs and caregivers regarding (a) DTTC treatment, as provided during the study, and (b) participating in a treatment research study.

Method:

Four SLPs and three …

Lessons In Longevity From Blood Stem Cells Under Protein Stress, André Catic

Center on Aging Staff Publications

Blood stem cells are among the body's longest-living cells despite being highly vulnerable to proteotoxic damage, which accelerates their aging. To maintain protein homeostasis (proteostasis), hematopoietic stem cells (HSCs) employ mechanisms such as reduced translation rates, high chaperone activity, autophagy, and selective protein degradation. These strategies mitigate protein misfolding, maintain quiescence, and preserve regenerative potential. Disruptions in proteostasis can lead to the elimination of impaired HSCs through differentiation or apoptosis, ensuring the integrity of the stem cell pool. Due to the systemic impact of the blood on aging and its experimental and clinical accessibility, investigating HSC proteostasis provides insights into …

Optimization Of Formula, Stability Testing, And Antioxidant Activity Of Clay Masks As Skin Moisturizers, Naniek Widyaningrum, Agung Dwi Anggoro Bhakti, Alghafiqy Harya Evan Maulana, Amalia Safitri, Adinda Fajrah Ramadhani, Anisa Febriani, Anggit Naufal Hanafi, Thendi Abdul Arief

Pharmaceutical Sciences and Research

Clay masks are cosmetic formulations designed to adhere closely to the skin, effectively lifting contaminants, cleansing the face, and absorbing impurities. We made a clay mask containing active ingredients such as niacinamide, alpha arbutin, ceramide, and hyaluronic acid. A careful selection of ingredients is essential for ensuring safety and mitigating potential dermatological issues. This study aimed to evaluate the physical characteristics, stability, primary irritation potential, and moisturizing efficacy of this clay mask formulation. Kaolin and bentonite are the primary base materials. The research included formulation optimization and physical stability testing using a cycling test, where each cycle was conducted over …

Elevated Nr2f1 Underlies The Persistence Of Invasive Disease After Treatment Of Braf-Mutant Melanoma, Manoela Tiago, Timothy J. Purwin, Casey D. Stefanski, Renaira Oliveira Da Silva, Mitchell E. Fane, Yash Chhabra, Jelan I. Haj, Jessica L. F. Teh, Rama Kadamb, Weijia Cai, Sheera Rosenbaum, Vivian Chua, Nir Hacohen, Michael A. Davies, Jessie Villanueva, Inna Chervoneva, Ashani T. Weeraratna, Dan A. Erkes, Claudia Capparelli, Julio A. Aguirre-Ghiso, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells. Given the similarities between drug tolerance and cellular dormancy, we studied the dormancy marker, nuclear receptor subfamily 2 group F member 1 (NR2F1), in response to BRAF-V600E inhibitors (BRAFi) plus MEK inhibitors (MEKi) in BRAF-mutant melanoma models. Transcriptomic analysis of melanoma patient samples treated with BRAFi + MEKi showed increased NR2F1. NR2F1 was highly expressed in the drug-tolerant invasive cell state of minimal residual disease in patient-derived and mouse-derived xenografts on BRAFi + MEKi. NR2F1 over-expression was sufficient …

Epigenomic Diagnosis And Prognosis Of Acute Myeloid Leukemia., Francisco Marchi, Vivek M. Shastri, Richard J. Marrero, Nam H K Nguyen, Antonella Öttl, Ann-Kathrin Schade, Marieke Landwehr, Olga Krali, Jessica Nordlund, Matin Ghavami, Fernando Sckaff, Vikash K. Mansinghka, Xueyuan Cao, William Slayton, Petr Starostik, Christopher R. Cogle, Raul C. Ribeiro, Jeffrey E. Rubnitz, Jeffery Klco, Abdelrahman Elsayed, Alan S. Gamis, Timothy J. Triche, Rhonda Ries, E Anders Kolb, Richard Aplenc, Todd Alonzo, Stanley Pounds, Soheil Meshinchi, Jatinder K. Lamba

Manuscripts, Articles, Book Chapters and Other Papers

Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe the Acute Leukemia Methylome Atlas, which includes robust models capable of accurately predicting AML subtypes. A genome-wide prognostic model as well as a targeted panel of 38 CpGs significantly predict five-year survival in our pediatric and adult test cohorts. To accelerate rapid clinical utility, we develop a specimen-to-result protocol that uses long-read nanopore sequencing and machine learning to characterize patients' whole genomes and epigenomes. Clinical validation …

In Silico Prediction Of Cytotoxic T-Cell Epitopes From Helicobacter Pylori Virulence Factors Using An Immunoinformatics Approach, Demy Valerie Chacon, Kiana Alika Co, Daphne Noreen Enriquez, Aubrey Love Labarda, Reanne Eden Manongsong, Edward Kevin B. Bragais

Biology Faculty Publications

Background: Helicobacter pylori infects approximately half of the global population, leading to gastric and duodenal ulcers. Despite the availability of antibiotics, challenges such as patient reluctance, high treatment costs, and antibiotic resistance limit their effectiveness, making vaccination a promising alternative. This study used immunoinformatics to identify candidate epitopes for a multiepitope vaccine construct against H. pylori.

Material and methods: The protein variability server was utilized for conservation analysis. The epitopes were screened for antigenicity, allergenicity, toxicity, cross-reactivity, and population coverage. Selected epitopes were docked with their corresponding human leukocyte antigen (HLA) alleles, and thermodynamic quantities were determined. Five virulence …

A Phase I Trial Of Evorpacept, Lenalidomide And Rituximab For Patients With B-Cell Non-Hodgkin Lymphoma, Paolo Strati, Lei Feng, Andrey Tyshevich, Darya Shavronskaya, Julia Alesse, Noel English, Elizabeth Sheehan, Nikita Syzrantsev, Alexander Nesmelov, Tony Z Zhuang, Dai Chihara, Jason R Westin, Sairah Ahmed, Luis E Fayad, Jared Henderson, Kylie Dent, Elizabeth Mcchesney, Sattva S Neelapu, Christopher R Flowers

Faculty, Staff and Student Publications

Introduction: SIRPα+ macrophages can mediate resistance to lenalidomide and rituximab (R2) in patients with B-cell non-Hodgkin lymphoma (B-NHL). Evorpacept (ALX148) is a novel CD47 blocker that abrogates interactions between lymphoma cells and SIRPα+ macrophages.

Methods: Adult patients with B-NHL who had received at least 2 prior lines of systemic therapy were included in this single arm phase I study (NCT05025800). Evorpacept was administered intravenously (IV), in a 28-day cycle, until progression, at two dose levels (DL): 30 mg/Kg on day (D) 1 and D15 (DL1), or 60 mg/Kg on day 1 (DL2); rituximab 375 mg/m2 IV was given …

Understanding Black American Pastors' Leadership Role And Interaction With Public Health During Covid-19, Stacy L. Tolbert

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic tested the leadership, response, and resilience of Black American pastors and their communities. These pastors played a crucial role in supporting their communities to lessen the impact the virus had on underlying health conditions and socioeconomic hardships that were exacerbated by the pandemic. Despite their efforts, Black American pastors frequently encountered challenges helping their community. The current research sought to understand the lived experiences of Black American pastors during the pandemic and their interactions with public health institutions to secure resources for their communities through Interpretative Phenomenological Analysis (IPA). The study was guided by the research question, …

Nursing Turnover Based On Age, Race, And Gender In Community Hospitals In Michigan, Laura Lawhorn

Walden Dissertations and Doctoral Studies

Hospitals struggle to maintain nursing staff to meet patient needs for a population that requires continuous care and experiences multiple illnesses. The purpose of this quantitative study was to investigate the variations in reasons for leaving the nursing profession (dependent variable) based on age, race, and gender (independent variables) within community hospitals in Michigan. The theoretical framework for this study was the Nursing Neuman Systems Model, which posits that nursing comprises four key components: environment, individual, nursing practice, and health. A correlational research design was utilized to address the research question and analyze the relationships between the variables. The secondary …

Implementation Of A Diabetic Complication Educational Intervention For Staff At A Community-Based Clinic, Virginia K. Dennis

Walden Dissertations and Doctoral Studies

Even though there are many modalities put in place to manage diabetes and its complications, there have been many barriers to reducing the complications associated with diabetes in health care institutions. In this educational intervention to reduce diabetes and its complications, a staff education program was implemented to enhance staff knowledge about diabetes and the complications associated with it. The staff education program was implemented at a community-based clinic for a DNP-prepared nurse, three RNs, and five medical assistants (MAs) working at the clinic. A pretest and a posttest were administered to assess the impact of the educational session. The …