Medicine and Health Sciences Commons^™

Mechanistic Study Of Pexidartinib-Induced Toxicity In Human Hepatic Cells, Si Chen, Yuxi Li, Xilin Li, Nan Mei, Xiaobo He, Matthew S Bryant, Xuan Qin, Feng Li, Lei Guo

Faculty, Staff and Students Publications

Pexidartinib, a tyrosine kinase inhibitor, was approved by the U.S. Food and Drug Administration in 2019 for treating adult patients with symptomatic tenosynovial giant cell tumors. Because of its hepatotoxicity risks, pexidartinib received a boxed warning; however, mechanistic studies on this hepatotoxicity remain limited. In this study, we demonstrate that pexidartinib decreases cell viability in primary human hepatocytes and hepatic HepG2 cells. A 24-h treatment with pexidartinib led to apoptosis in HepG2 cells, as evidenced by increased caspase 3/7 activity and the induction of cleaved PARP and γ-H2A.X. Pexidartinib-induced endoplasmic reticulum (ER) stress was observed at early time points of …

Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo

School of Graduate Studies Faculty Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …

Interoperability As A Catalyst For Digital Health And Therapeutics: A Scoping Review Of Emerging Technologies And Standards (2015–2025), Kola Adegoke, Abimbola Adegoke, Deborah Dawodu, Akorede Adekoya, Ayoola Bayowa

Health & Biomedical Sciences Faculty Publications

Background: Interoperability is fundamental for advancing digital health and digital therapeutics, particularly with the integration of technologies such as artificial intelligence (AI), blockchain, and federated learning. Low- and middle-income countries (LMICs), where digital infrastructure remains fragmented, face specific challenges in implementing standardized and scalable systems. Methods: This scoping review was conducted using the Arksey and O’Malley framework, refined by Levac et al., and the Joanna Briggs Institute guidelines. Five databases (PubMed, Scopus, IEEE Xplore, ACM Digital Library, and Google Scholar) were searched for peer-reviewed English language studies published between 2015 and 2025. We identified 255 potentially eligible articles and selected …

Completion Rates For Ecological Momentary Assessments Of Food Intake During Pregnancy And Post Partum: Descriptive Study, Sarah Annalise Sanders, Serwaa Omowale, Andrea Casas, Alexis Kiyanda, Abigail Smith Kosbie, Yu-Hsuan Lai, Meredith Wallace, Stephen Rathbun, Tiffany Gary-Webb, Esa Davis, Lora Burke, Dara Méndez

Faculty, Staff and Student Publications

Background: The collection of dietary behavior data is crucial in childbearing populations. In addition to observed inequities in perinatal dietary intake and quality, burdensome assessment methods (eg, 24-h dietary recall) may limit research participation for some groups. Ecological momentary assessment (EMA) is associated with reduced recall bias and participant convenience, but there is a dearth of studies with diverse cohorts.

Objective: Our aim is to describe participant completion of food intake items in EMA surveys, overall and across individual characteristics (eg, prepregnancy BMI).

Methods: Using secondary EMA data from participants in a longitudinal study, we report average completion rates of …

Clinical Utility Of Diffusion Tensor Imaging In Sport-Related Concussion: A Systematic Review, Shiv Patil, Rithvik Kata, Serhat Aydin, Mert Karabacak, Konstantinos Margetis, Sotirios Bisdas

Student Papers, Posters & Projects

OBJECTIVE: Sport-related concussion (SRC) is a prevalent form of traumatic brain injury that is associated with long-term neurological and psychiatric impairment, particularly among athletes with a history of repetitive concussions. The biological variability of SRC's impact on the brain, as well as a lack of objective biomarkers to diagnose and prognosticate concussion, has prompted interest in advanced neuroimaging methods such as diffusion tensor imaging (DTI). By measuring disruptions in water diffusivity due to head trauma, DTI can detect alterations in white matter integrity that are not visualized by conventional imaging methods. This systematic review aims to synthesize major trends and …

Failure To Rescue After Surgery For Pancreatic Cancer: A Systematic Review And Narrative Synthesis Of Risk Factors And Safety Strategies, Masashi Uramatsu, Yoshikazu Fujisawa, Paul Barach, Hiroaki Osakabe, Moe Matsumoto, Yuichi Nagakawa

College of Population Health Faculty Papers

Background: Failure to rescue (FTR), defined as death after major postoperative complications, is a critical quality indicator in pancreatic cancer surgery. Despite advances in surgical techniques and perioperative care, FTR rates remain high and vary across institutions. Methods: This systematic review uses a narrative synthesis followed by PRISMA 2020. A PubMed search (1992-2025) identified 83 studies; after screening, 52 studies (2010-2025) were included. Eligible designs were registry-based, multicenter, single-center, or prospective audits. Given substantial heterogeneity in study designs, FTR definitions, and outcome measures, a narrative synthesis was performed; no formal risk-of-bias assessment or meta-analysis was conducted. Results: …

A Neuroimmune Cerebral Assembloid Model To Study The Pathophysiology Of Familial Alzheimer's Disease, Andrea Becerra-Calixto, Anik Banerjee, Huihui Fan, Chunfeng Tan, Eunyoung Lee, Louise D Mccullough, Juneyoung Lee

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is the leading cause of dementia globally. The accumulation of amyloid and tau proteins, neuronal cell death and neuroinflammation are seen with AD progression, resulting in memory and cognitive impairment. Microglia are crucial for AD progression as they engage with neural cells and protein aggregates to regulate amyloid pathology and neuroinflammation. Recent studies indicate that microglia contribute to the propagation of amyloid beta (Aβ) via their immunomodulatory functions including Aβ phagocytosis and inflammatory cytokine production. Three-dimensional cell culture techniques provide the opportunity to study pathophysiological changes in AD in human-derived samples that are difficult to recapitulate in …

One-Sided Matching Portal (Osmp): A Tool To Facilitate Rare Disease Patient Matchmaking., Matthew Osmond, E Magda Price, Orion J. Buske, Mackenzie Frew, Madeline Couse, Taila Hartley, Conor Klamann, Hannah G B H Le, Jenny Xu, Delvin So, Anjali Jain, Kevin Lu, Kevin Mo, Hannah Wyllie, Erika Wall, Hannah G. Driver, Warren A. Cheung, Ana S A Cohen, Emily G. Farrow, Isabelle Thiffault, Care Rare Canada Consortium, Andrei L. Turinsky, Tomi Pastinen, Michael Brudno, Kym M. Boycott

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Genomic matchmaking-the process of identifying individuals with overlapping phenotypes and rare variants in the same gene-is an important tool facilitating gene discoveries for unsolved rare genetic disease (RGD) patients. Current approaches are two-sided, meaning both patients being matched must have the same candidate gene flagged. This limits the number of RGD patients eligible for matchmaking. One-sided matchmaking, in which a gene of interest is queried in the genome-wide sequencing data of RGD patients, would make matchmaking possible for previously undiscoverable individuals. However, platforms and workflows for this approach have not been well established.

RESULT: We released a beta version …

Synaptic Transmission Promotes Brain Metastatic Outgrowth In Breast Cancer, Jayanta Mondal, Patrick Nylund, Prit Benny Malgulwar, William E Johnson, Jason T Huse

Faculty, Staff and Student Publications

This work demonstrates that normal neuron-to-neuron signaling machinery is hijacked by metastasizing cancer cells during their outgrowth in the central nervous system.

Quiescent Oxphos-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend On Bcl-Xl For Survival, Slawomir Andrzejewski, Marie Winter, Leandro Encarnacao Garcia, Olusiji Akinrinmade, Francisco Madeira Marques, Emmanouil Zacharioudakis, Anna Skwarska, Julio Aguirre-Ghiso, Marina Konopleva, Guangrong Zheng, Susan A Fineberg, Daohong Zhou, Evripidis Gavathiotis, Tao Wang, Eugen Dhimolea

Faculty, Staff and Student Publications

The persistent residual tumor cells that survive after chemotherapy are a major cause of treatment failure, but their survival mechanisms remain largely elusive. These cancer cells are typically characterized by a quiescent state with suppressed activity of MYC and MTOR. We observed that the MYC-suppressed persistent triple-negative breast cancer (TNBC) cells are metabolically flexible and can upregulate mitochondrial oxidative phosphorylation (OXPHOS) genes and respiratory function ("OXPHOS-high" cell state) in response to DNA-damaging anthracyclines such as doxorubicin, but not to taxanes. The elevated biomass and respiratory function of mitochondria in OXPHOS-high persistent cancer cells were associated with mitochondrial elongation and remodeling, …

Barriers And Facilitators Of Implementing A Community Workshop Series To Mitigate Maternal-Child Food Insecurity: A Mixed-Methods Re-Aim Evaluation, Kristen Herlosky, Ana Baumann, Et Al.

2020-Current year OA Pubs

BACKGROUND: Community-led workshops offer promising health education models to advance maternal-child health equity by providing culturally congruent spaces for information sharing, resource access, and social support building. This study aimed to (1) document the participatory co-creation of a Community Workshop Series with topics across the Nurturing Care Framework domains (health, nutrition, early learning, security/safety, responsive caregiving) to mitigate maternal-child food insecurity, (2) evaluate CWS effectiveness in increasing participants' knowledge across the Nurturing Care Framework, and (3) identify CWS implementation barriers and facilitators.

METHODS: The study employed two-phases: Phase One engaged members of a Community Advisory Board in participatory research to …

Transcriptional Responses Of Mouse Proximal Colon And Colonoids During Early Whipworm Infection, Hyeim Jung, Joseph F Urban, Bruce A Rosa, Makedonka Mitreva

2020-Current year OA Pubs

Trichuriasis, caused by the parasitic nematode

Pathologist-Like Explainable Ai For Interpretable Gleason Grading In Prostate Cancer, Gesa Mittmann, Nidia Messias, Et Al.

2020-Current year OA Pubs

No abstract provided.

Hydroxyapatite Microspheres Induce Durable Pleurodesis And Are Rapidly Cleared By Pleural Osteoclasts, Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. Mccormack

2020-Current year OA Pubs

Talc pleurodesis is highly effective for preventing recurrence of pneumothorax and pleural effusion, but it can be complicated by dissemination, acute lung injury, lead exposure, and foreign body-induced chronic inflammation and pain. Our objective is to develop a safe, biodegradable, contaminant-free particle for pleurodesis. We used mouse models of pneumothorax and malignant pleural effusion to compare the efficacy and safety of pleurodesis with talc and hydroxyapatite microspheres (HAM). Intrapleural instillation of microspheres induced pleural adhesions, fibrosis, and symphysis as effectively as talc and resulted in more durable protection from experimental pneumothorax. HAM and talc both induced an osteoclastogenic, inflammatory, and …

Gabaergic Interneurons Contribute To The Fatal Seizure Phenotype Of Cln2 Disease Mice, Keigo Takahashi, Nicholas R. Rensing, Elizabeth M. Eultgen, Letitia L. Williams, Sophie H. Wang, Hemanth R. Nelvagal, Steven Q. Le, Marie S. Roberts, Balraj Doray, Edward B. Han, Patricia I. Dickson, Michael Wong, Mark S. Sands, Jonathan D. Cooper

2020-Current year OA Pubs

The cellular etiology of seizures in CLN2 disease, a childhood-onset neurodegenerative lysosomal storage disorder caused by a deficiency of tripeptidyl peptidase 1 (TPP1), remains elusive. Given that Cln2R207X/R207X mice display fatal spontaneous seizures and an early loss of several cortical GABAergic interneuron populations, we hypothesized that these 2 events might be causally related. To study the cell-autonomous effects of interneuron-specific TPP1 deficiency, we first generated transgenic mice expressing loxP-flanked lysosomal membrane-tethered TPP1 (TPP1LAMP1 mice) on the Cln2R207X/R207X genetic background, and then crossed TPP1LAMP1 mice with Vgat-Cre mice. These Vgat-Cre; TPP1LAMP1 mice accumulated storage material in cortical and striatal interneurons. Vgat-Cre; …

Diverse Presentations Of Aphasia: A Comparative Analysis Of Polysynthetic And Analytic Languages Through Kanien'keha (Mohawk) And English Morphology And Syntax, Halle L. Elder

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper looks to compare two linguistically diverse languages, English and Kanien'keha, a native American language commonly known as Mohawk. The comparison will revolve around the morphology and syntax typologies of these two languages. In addition to the morphological and syntactic comparison, I will discuss how aphasia presents itself in different language typologies, placing this comparison onto English and Kanien'keha. The research questions I look to answer are: How does word formation and sentence structure differ between English and Kanien'kéha? Does aphasia present differently in analytic and polysynthetic languages like English and Kanien'kéha? The morphological data and syntactic data are …

Successful Therapeutic Response Of Intravenous Immunoglobulin In Guillain-Barre Syndrome With Onset More Than Two Weeks: A Case Report, Ezra Immanuelly Pribadi, Fauna Herawati, Valentinus Besin, Marisca Evalina Gondokesumo

Chulalongkorn Medical Journal

Guillain-Barré Syndrome (GBS), with a global incidence of 1–2 cases per 100,000 population annually, remains the most common cause of acute flaccid paralysis. Standard treatment includes plasma exchange within 4 weeks or intravenous immunoglobulin (IVIg) within 2 weeks of symptom onset. However, IVIg may still benefit selected late-presenting cases. Here, we report a case a 17-year-old male presented with progressive bilateral limb weakness and paresthesia that began approximately 3 weeks before admission. He also experienced a brief syncope episode and defecation syncope, indicating possible autonomic involvement. On hospital day 3, after shared decision-making, the family opted for IVIg over plasma …

A Rare Variation In The Branching Pattern Of The Axillary Artery, Preethi Umanath, Sutha Selvaraj

Chulalongkorn Medical Journal

ABSTRACT:

BACKGROUND: This study aims to elucidate a previously unreported rare variation in the branching pattern of the third part of the axillary artery.

Results and discussion: During the routine dissection of a male cadaver, it was observed that the third part branches of the left axillary artery, specifically the anterior and posterior circumflex humeral arteries, were completely absent. To compensate for the missing branches, an unusual ascending branch emerged from the arteria profunda brachii (a branch of the brachial artery). This branch later divided into two: the deltoid branch, which accompanied the axillary nerve, entered in to …

Morphological And Biological Properties Of Platelet Rich Fibrin Membrane Producing From Different Centrifugation Protocols, Vannarut Satitpitakul Md, Sarisa Tangkhunchaisaeng

Chulalongkorn Medical Journal

Background: Platelet-rich fibrin (PRF) membranes represent a promising tool for corneal epithelial disease treatment, though a standardized protocol remains unestablished. Objective: This study aimed to evaluate the morphological and biological properties of Platelet-Rich Fibrin (PRF) membranes producing from different centrifugation protocols Methods: Four distinct low speed centrifugation protocols (100g/5min, 200g/5min, 100g/10min, and 200g/10min) were established for PRF production from 3 healthy volunteers. We assessed fibrin and membrane dimensions, white blood cell and platelet concentrations, kinetic release of growth factors (TGF-, PDGF-BB, VEGF, IGF-1), and inflammatory cytokines (IL-6, IL-1, TNF-). In vitro degradation and bacterial contamination were also examined. Results: All …

The Impact Of G6pd Deficiency On Liver Damage And Disease Progression In Hepatocellular Carcinoma: A Cross-Sectional Study In Thailand, Watcharapong Jugnam-Ang, Phatchayanat Tansakul, Makamas Chanda, Poonlarp Cheepsunthorn, Pisit Tangkijvanich, Chalisa L. Cheepsunthorn Ph.D.

Chulalongkorn Medical Journal

Background. Glucose 6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway, producing reduced nicotinamide adenine dinucleotide phosphate (NADPH) to support redox homeostasis and cancer cell proliferation. While G6PD deficiency has been linked to reduced cancer risk, its impact on hepatocellular carcinoma (HCC) remains unclear.

Objectives. This study investigates the prevalence of G6PD deficiency in HCC patients and its association with clinical parameters across disease stages.

Methods. A cross-sectional study analyzed G6PD activity and clinical data from 174 HCC patients, 100 hepatitis B virus (HBV)-infected patients, and 154 healthy controls. Peripheral blood G6PD activity was measured, and …

Investigating The Organs At Risk (Oar) Received Dose During Prostate Cancer Therapy Using Intensity Modulated Radiation Therapy (Imrt) And 3d Conformal Radiotherapy (3dcrt): A Comparison Study, Talib Abdulwahid, Hussein Mraity, Mustafa Al-Aseebee, Zeyad Al-Dulaimi, Ali Abid Abojassim

Chulalongkorn Medical Journal

Radiotherapy domain is known to impose undesired risk of radiation to normal tissue surrounding the tumor. So, the treatment planning systems are developing with time to introduce a perfect treatment. Organs at risks surrounding prostate tumors are sensitive to high doses of radiation. This study is aimed at comparing the efficiency of the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT) techniques during the treatment of prostate cancer. A cross-sectional study was performed in Middel Euphrate Csancer Center, Najaf , Iraq. A 25 patients with prostate tumor were enrolled. They underwent CT scans from imaging then treated with x-ray …

Effectiveness Of Vitamin D3 In Facilitating The Therapeutic Progression Of Healing Diabetic Foot Ulcers, Fatemeh Nouri, Sara Aghaei, Gülüzar Özbolat, Yusuf Döğüş, Mahdi Mirhamidi, Reza Rahimi Barghani, Amin Daemi

Chulalongkorn Medical Journal

Background: Today’s, diabetes and its complications have afflicted a large population all over the world, so that it is estimated that its prevalence in all age groups will reach from 2.8% in 2000 to 4.4% in 2030. It is well known that vitamin D may cause rapid wound healing and anti-inflammatory.

Objective: Regarding the importance of the quality of life of diabetic patients and the improvement of chronic diabetic foot ulcers, this paper aims to investigate the efficacy of vitamin D3 on the healing of diabetic foot ulcers. The present research is conducted as a randomized controlled trial.

Methods: …

Non-Invasive Way For Detection Of Neonatal Jaundice Using Gbr, Priti V. Bhagat, Mukesh Raghuwanshi, Ashutosh D. Bagde

Chulalongkorn Medical Journal

Background: Neonatal jaundice is a common condition in newborns due to excess levels of bilirubin. The traditional method for bilirubin testing is invasive, i.e., through blood tests only, which is painful to infants. Therefore, this study uses machine learning algorithms to develop a non-invasive way to detect neonatal jaundice.

Objectives: Design a computer-aided support system to detect neonatal jaundice using machine learning algorithm.

Methods: The gradient-boosting regression model is used to predict the bilirubin level. Gradient Boosting is a robust boosting algorithm that combines several weak learners into strong learners, in which each new model is trained to minimize the …

The Comparison Of Radiation Attenuation Correction Techniques For Relative Renal Function In Renal Cortical Scintigraphy, Benchamat Phromphao, Sorasak Wanitchanan, Trai Chairat, Thunyaluk Sawatnatee, Tanawat Sontrapornpol

Chulalongkorn Medical Journal

Background: Renal cortical scintigraphy using Tc-99m Dimercaptosuccinic acid (Tc-99m DMSA) is the detection of cortical abnormalities. In addition, relative renal function (RRF) is performed by DMSA scintigraphy and estimated from the radiopharmaceutical uptake in both kidneys with radiation attenuation correction. Generally, attenuation correction is calculated from mathematic methods with kidney depth correction for an accurate renal function value.

Objective: The purpose of this research was to study the correlation of the RRF with radiation attenuation correction by geometric mean (GM) method and kidney depth correction by Beer-Lambert law equation.

Methods: Researchers studied in the spherical phantom, kidney phantom and patient’s …

Periodontal Status In Patients With Chronic Skin Diseases: A Pilot Study, Hao Nguyen, Thuy Nguyen, Thuy Vo, Huong Duong, Hoa Ho, Nhi Pham, Nguyen Pham, Nam Huynh

Chulalongkorn Medical Journal

Background: Many skin diseases, especially those that also involve the oral mucosa lesions might play an important role in the etiopathogenesis of oral health and mucocutaneous inflammation. The presence of these oral sores may make it more difficult to maintain good oral hygiene, which increases plaque accumulation and raises the risk of developing periodontal disease.

Objectives: This study aimed to evaluate and compare the periodontal status of chronic skin disease (CSD) patients with healthy controls.

Methods: 109 patients and 37 healthy subjects were included in this study. Parameters evaluated included bleeding on probing index (BOP), periodontal pocket depths (PPD), clinical …

Treatment Of Biopsy-Proven Laryngeal Squamous Cell Carcinoma In Situ, Praneet C. Kaki, Aman M. Patel, Lily Huang, Gavin Turner, Afash Haleem, Jason A. Brant, Robert M. Brody, Ryan M. Carey

SKMC Student Presentations and Publications

OBJECTIVE: To investigate the impact of clinical surveillance, primary radiotherapy, and primary surgery on overall survival (OS) in laryngeal carcinoma in situ (Cis).

METHODS: The 2006-2020 National Cancer Database was queried for adults with a biopsy-proven diagnosis of laryngeal Cis. Multivariable binary logistic and Cox proportional hazards regression models were implemented.

RESULTS: Of 3567 unique patients satisfying inclusion criteria, 514 (14.4%) underwent clinical surveillance, 1074 (30.1%) underwent primary radiotherapy, and 1979 (55.5%) underwent primary surgery. Receiving treatment at an academic/research facility was associated with higher odds of undergoing primary surgery compared to primary radiotherapy. Among 646 patients undergoing primary surgery …

Methemoglobinemia-Induced Cardiac Dysfunction In A Pediatric Patient, Brian Drury, Chelsea Boyd, Kelsey Van Housen, Siraj Amanullah

Student Papers, Posters & Projects

Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning— in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan …

Impact Of Obicetrapib On Major Adverse Cardiovascular Events In High-Risk Patients: A Pooled Analysis, Stephen J Nicholls, Adam J Nelson, Kausik K Ray, Christie M Ballantyne, Marc Ditmarsch, Douglas Kling, Andrew Hsieh, Michael Szarek, John J Kastelein, Michael H Davidson

Faculty, Staff and Students Publications

Background: The cholesteryl ester transfer protein inhibitor obicetrapib decreases levels of atherogenic lipids and raises high-density lipoprotein cholesterol (HDL-C).

Objectives: In this study, we sought to determine the effect of obicetrapib on cardiovascular events.

Methods: The effects of 10 mg obicetrapib and placebo daily on major adverse cardiovascular event (MACE) rates were investigated in a pooled analysis of 354 patients with heterozygous familial hypercholesterolemia (HeFH) and 2,530 patients with atherosclerotic cardiovascular disease (ASCVD) over 365 days. The association between on-treatment lipids and MACE were also investigated.

Results: The cohort (mean age 66 years, 36% female, ASCVD 82%, HeFH 27%, diabetes …

Factors Associated With Corrective Actions, Remediation, And Employment Termination Of Emergency Physicians, Lyndsay Tyler, Yachana Bhakta, Michael Gottlieb, Chadd K. Kraus, Terry Kowalenko, Yvette Calderon, Samuel M. Keim, Diane L. Gorgas, Deborah B. Diercks, Lewis S. Nelson

Department of Emergency Medicine Faculty Papers

OBJECTIVE: Medical professionalism is fundamental to the delivery of high-quality patient care. There is a paucity of data to describe behaviors associated with negative professional and employment outcomes. This study examines common factors leading to corrective actions, remediation, and termination of emergency physicians (EPs).

METHODS: This was a cross-sectional survey sent to academic chairs in emergency medicine to identify factors for corrective actions, remediation, or termination of EPs. Survey items were piloted and response process validity gathered prior to administration. Data are reported as descriptive statistics.

RESULTS: 60 of 167 (36 %) members of the Association of Academic Chairs in …

Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan

Faculty, Staff and Student Publications

The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably, genetics and nutrition interdependently control more than 80% of rhythmic gene and enhancer-promoter interactions (E-PIs), with a noncanonical clock regulator, estrogen-related receptor gamma (ESRRγ), emerging as a top transcription factor during motif mining. Knockout of Esrrγ abolishes strain-specific metabolic processes in response to …