Medicine and Health Sciences Commons^™

Meningococcal Vaccination: Recommendations Of The Advisory Committee On Immunization Practices, United States, 2020, S. A. Mbaeyi, C. H. Bozio, J. Duffy, L. G. Rubin, S. Hariri, D. S. Stephens, J. R. Macneil

Journal Articles

© 2020. This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of meningococcal vaccines in the United States. As a comprehensive summary and update of previously published recommendations, it replaces all previously published reports and policy notes. This report also contains new recommendations for administration of booster doses of serogroup B meningococcal (MenB) vaccine for persons at increased risk for serogroup B meningococcal disease. These guidelines will be updated as needed on the basis of availability of new data or licensure of new meningococcal vaccines. ACIP recommends routine vaccination with a quadrivalent …

Physician Perceptions Of Adhd Stimulant Diversion And Misuse, N. M. Colaneri, S. A. Keim, A. Adesman

Journal Articles

© The Author(s) 2016. Objective: The recent rise in ADHD has prompted concerns about adolescents with ADHD diverting and/or misusing stimulants. This is the first study to assess physician perceptions of the pervasiveness of these issues. Method: Questionnaires were mailed to a national sample of pediatric subspecialists. Responses were analyzed (n = 826; 18% response rate) using descriptive statistics and regression analyses. Results: In the past year, 59% of physicians suspected ≥1 patient(s) with ADHD diverted stimulants. Seventy-four percent believed ≥1 patient(s) feigned symptoms to obtain an initial ADHD diagnosis; 66% believed ≥1 patient(s) wanted stimulants to improve academic performance. …

Pandemic-Related Submissions: The Challenge Of Discerning Signal Amidst Noise, L. J. Kaplan, T. P. Bleck, T. G. Buchman, R. P. Dellinger, C. S. Deutschman, J. C. Marshall, D. M. Maslove, H. Masur, M. M. Parker, J. J. Zimmerman, +4 Additional Authors

Journal Articles

No abstract provided.

Patient And Physician Discordance Of Global Disease Assessment In Juvenile Dermatomyositis: Findings From The Childhood Arthritis & Rheumatology Research Alliance Legacy Registry, H. Tory, D. Zurakowski, S. Kim, L. Abramson, E. Anderson, M. Andrew, N. Battle, M. Becker, B. Gottlieb, M. Simmons, +90 Additional Authors

Journal Articles

© 2020 The Author(s). Background: Global disease activity scores (gVAS) capture patient or family (PF) and physician (MD) assessments of disease. This study sought to measure discordance between PF and MD global activity scores in juvenile dermatomyositis (JDM), and determine factors associated with discordance. Methods: Patients with JDM were included from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry (N = 563). PF and MD gVAS were assessed for discordance, defined as a ≥ 2-point difference. Factors associated with discordant gVAS were compared in univariate analysis. Multivariable regression analysis was used to identify predictors of discordance. Results: Almost …

Outcome Measurement Instruments For Peripheral Vascular Malformations And An Assessment Of The Measurement Properties: A Systematic Review, S. E. Horbach, A. P. Rongen, R. G. Elbers, C. M. Van Der Horst, C. A. Prinsen, P. I. Spuls, F. Blei, C. J. Van Der Vleuten, I. J. Frieden, L. M. Boon, +4 Additional Authors

Journal Articles

© 2019, The Author(s). Purpose: The Outcome measures for vascular malformation (OVAMA) group reached consensus on the core outcome domains for the core outcome set (COS) for peripheral vascular malformations (venous, lymphatic and arteriovenous malformations). However, it is unclear which instruments should be used to measure these domains. Therefore, our aims were to identify all outcome measurement instruments available for vascular malformations, and to evaluate their measurement properties. Methods: With the first literature search, we identified outcomes and instruments previously used in prospective studies on vascular malformations. A second search yielded studies on measurement properties of patient- and physician-reported instruments …

Proceedings From The 2NdNext Gen Therapies For Systemic Juvenile Idiopathic Arthritis And Macrophage Activation Syndrome Symposium Held On October 3-4, 2019, S. W. Canna, G. S. Schulert, A. De Jesus, A. Pickering, H. Brunner, M. Gadina, S. Levine, R. Goldbach-Mansky, B. Gottlieb, V. Delgaizo, +20 Additional Authors

Journal Articles

© 2020 The Author(s). For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arthritis (SJIA) are now increasingly diagnosed with life-threatening chronic complications, including hepatitis and lung disease (SJIA-LD). On October 3-4, 2019, a two-day meeting, NextGen Therapies for Systemic Juvenile Idiopathic Arthritis (SJIA) & macrophage activation syndrome (MAS) organized by the Systemic JIA Foundation (www.systemicjia.org/) in Washington, DC brought together scientists, clinicians, parents and FDA representatives with the objectives (1) to integrate clinical and research findings in MAS and SJIA-LD, and …

Sleep Spindles Promote The Restructuring Of Memory Representations In Ventromedial Prefrontal Cortex Through Enhanced Hippocampal-Cortical Functional Connectivity, E. Cowan, A. Liu, S. Henin, S. Kothare, O. Devinsky, L. Davachi

Journal Articles

No abstract provided.

The Longitudinal Relationship Between Patient-Reported Outcomes And Clinical Characteristics Among Patients With Focal Senorthwell Healthntal Glomerulosclerosis In The Nephrotic Syndrome Study Network, J. P. Troost, A. Waldo, N. E. Carlozzi, S. Murphy, F. Modersitzki, H. Trachtman, P. H. Nachman, C. B. Sethna, P. Singer, D. S. Gipson, +36 Additional Authors

Journal Articles

No abstract provided.

Turner Syndrome With Y Chromosome: Spontaneous Thelarche, Menarche, And Risk Of Malignancy, E. Dabrowski, E. K. Johnson, V. Patel, Y. Hsu, S. Davis, A. L. Goetsch, R. Habiby, W. J. Brickman, C. Finlayson

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No abstract provided.

The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities∗, C. S. Deutschman, J. Hellman, R. Ferrer Roca, D. De Backer, C. M. Coopersmith

Journal Articles

© 2020 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved. Objectives: Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data Sources: Original paper, search of the literature. Study Selection: By several members of the original task force with specific expertise in basic/translational science. Data Extraction: None. Data Synthesis: None. Conclusions: In the first of a series of follow-up reports to the original paper, several members of the original task …

Treatment Of Children And Adolescents Who Are Overweight Or Obese, S. Di Figlia-Peck, R. Feinstein, M. Fisher

Journal Articles

No abstract provided.

Urinary Epidermal Growth Factor As A Marker Of Disease Progression In Children With Nephrotic Syndrome, D. S. Gipson, H. Trachtman, A. Waldo, K. L. Gibson, S. Eddy, K. M. Dell, T. Srivastava, K. V. Lemley, C. B. Sethna, W. Ju, +18 Additional Authors

Journal Articles

© 2019 International Society of Nephrology Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome. Methods: The study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal seNorthwell Healthntal glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for …

Highly Sensitive Blocker Displacement Amplification And Droplet Digital Pcr Reveal Low-Level Parental Foxf1 Somatic Mosaicism In Families With Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins., J. A. Karolak, Q. Liu, N. G. Xie, L. R. Wu, G. Rocha, E. K. Fiorino, M. Edelman, J. Fox, D. A. Hayes, P. Stankiewicz, +9 Additional Authors

Journal Articles

Detection of low-level somatic mosaicism [alternate allele fraction (AAF) ≤ 10%] in parents of affected individuals with the apparent de novo pathogenic variants enables more accurate estimate of recurrence risk. To date, only a few systematic analyses of low-level parental somatic mosaicism have been performed. Herein, highly sensitive blocker displacement amplification, droplet digital PCR, quantitative PCR, long-range PCR, and array comparative genomic hybridization were applied in families with alveolar capillary dysplasia with misalignment of pulmonary veins. We screened 18 unrelated families with the FOXF1 variant previously determined to be apparent de novo (n = 14), of unknown parental origin (n …

Clinical Practices For Measles-Mumps-Rubella Vaccination Among Us Pediatric International Travelers., E. P. Hyle, S. R. Rao, A. C. Bangs, P. Gastañaduy, A. P. Fiebelkorn, S. H. F. Hagmann, A. T. Walker, R. P. Walensky, E. T. Ryan, R. C. Larocque

Journal Articles

Importance: The US population is experiencing a resurgence of measles, with more than 1000 cases during the first 6 months of 2019. Imported measles cases among returning international travelers are the source of most US measles outbreaks, and these importations can be reduced with pretravel measles-mumps-rubella (MMR) vaccination of pediatric travelers. Although it is estimated that children account for less than 10% of US international travelers, pediatric travelers account for 47% of all known measles importations.

Objective: To examine clinical practice regarding MMR vaccination of pediatric international travelers and to identify reasons for nonvaccination of pediatric travelers identified as MMR …

Development And Performance Of A Web-Based Tool To Adjust Urine Toxicology Testing Frequency: Retrospective Study, K. B. Chapman, M. M. Pas, D. Abrar, W. Day, K. C. Vissers, N. Van Helmond

Journal Articles

Background: Several pain management guidelines recommend regular urine drug testing (UDT) in patients who are being treated with chronic opioid analgesic therapy (COAT) to monitor compliance and improve safety. Guidelines also recommend more frequent testing in patients who are at high risk of adverse events related to COAT; however, there is no consensus on how to identify high-risk patients or on the testing frequency that should be used. Using previously described clinical risk factors for UDT results that are inconsistent with the prescribed COAT, we developed a web-based tool to adjust drug testing frequency in patients treated with COAT. Objective: …

Impact Of Race, Gender, And Clinical Risk Factors On Outcomes Following Treatment Of Unruptured Intracranial Aneurysms, Andrew Koo

Yale Medicine Thesis Digital Library

INTRODUCTION: In an unprecedented era of soaring healthcare costs, payers and providers alike have started to place increased importance on measuring the quality of surgical procedures as surrogate markers for operative success. Length of hospital stay (LOS) and discharge disposition during index admission are two metrics increasingly used. For the treatment of unruptured cerebral aneurysms, the determinants of extended length of stay and poor discharge disposition remain relatively unknown.

OBJECTIVES: 1) To investigate the influence that patient demographics, such as gender and race, have on post-procedural discharge disposition after treatment of unruptured aneurysms, and 2) To identify the nationwide impact …

Disease Site-Specific Guidelines For Curative Radiation Treatment During 'Limited Surgery' And 'Hospital Avoidance': A Radiation Oncology Perspective From The Epicenter Of Covid-19 Pandemic., B Parashar, Wc Chen, Jm Herman, L Potters

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No abstract provided.

Repurposing Orthopaedic Residents Amid Covid-19: Critical Care Prone Positioning Team., O. F. Rahman, D. P. Murray, R. M. Zbeda, A. D. Volpi, A. Z. Mo, N. A. Wessling, B. A. Mina, M. S. Mendez-Zfass, C. Carpati

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No abstract provided.

Histopathologic Evaluation Of Placentas After Diagnosis Of Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection., M. Gulersen, L. Prasannan, H. Tam Tam, C. N. Metz, B. Rochelson, N. Meirowitz, W. Shan, M. Edelman, K. A. Millington

Journal Articles

Background: The impact of maternal severe acute respiratory syndrome coronavirus 2 infection on placental histopathology is not well known.

Objective: To determine if any significant placental histopathologic changes occur after the diagnosis of severe acute respiratory syndrome coronavirus 2 infection during pregnancy and whether these changes are correlated with the presence or absence of symptoms associated with the infection.

Study Design: A retrospective cohort study of women diagnosed as having severe acute respiratory syndrome coronavirus 2 infection who delivered at a single center from April 9, 2020 to April 27, 2020, and had placental specimens reviewed by the Department of …

Adherence And Acceptability Of Telehealth Appointments For High-Risk Obstetrical Patients During The Coronavirus Disease 2019 Pandemic., S. Jeganathan, L. Prasannan, M. J. Blitz, N. Vohra, B. Rochelson, N. Meirowitz

Journal Articles

Background: Telehealth has been successfully implemented for the delivery of obstetrical care. However, little is known regarding the attitudes and acceptability of patients and providers in high-risk obstetrics and whether the implementation of a telehealth model improves access to care in nonrural settings.

Objective: This study aimed to describe patient and provider attitudes toward telehealth for the delivery of high-risk obstetrical care in a large healthcare system with both urban and suburban settings and to determine whether the implementation of a telehealth model improves patient adherence to scheduled appointments in this patient population.

Study Design: Two self-administered surveys were designed. …

Endoscopic Evaluation Of Inflammatory Bowel Disease With High-Grade Dysplasia Should Not Be Delayed During The Covid-19 Pandemic: A Case Report, K. L. Raphael, A. J. Trindade, H. M. Zimmerman, K. S. Sultan

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No abstract provided.

Impact Of Covid - 19 Pandemic On Orthopaedics At Northwell Health, New York., B. Petrone, C. Iturriaga, T. Mauri, N. Sgaglione

Journal Articles

The Novel Coronavirus (COVID-19) pandemicplaced an immense strain on healthcare systems and orthopedic surgeons across the world. To limit the spread, federal and state governments mandated the cancellation of all non-urgent surgical cases to address surging hospital admissions and manage workforce and resource reallocation. During the pandemic surge, thousands of surgical cancellations have been required. We outline our experience through the onset and advance of the surge, detail our incident response, and discuss the transition toward recovery.

Letter: Surgical Management Of Brain Tumor Patients In The Covid-19 Era, Be Zacharia, Dg Eichberg, Me Ivan, S Hanft, Ja Boockvar, H Isildak, A Mansouri, Rj Komotar, Rs D'Amico

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No abstract provided.

Management Of Upper Gi Bleeding In Patients With Covid-19 Pneumonia, K Cavaliere, C Levine, P Wander, Dv Sejpal, Aj Trindade

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No abstract provided.

Pregnant Vs Nonpregnant Severe Acute Respiratory Syndrome Coronavirus 2 And Coronavirus Disease 2019 Hospital Admissions: The First 4 Weeks In New York, A Tekbali, A Grünebaum, A Saraya, L Mccullough, E Bornstein, Fa Chervenak

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No abstract provided.

Targeting Potential Drivers Of Covid-19: Neutrophil Extracellular Traps., Bj Barnes, Jm Adrover, A Baxter-Stoltzfus, A Borczuk, J Cools-Lartigue, Jm Crawford, J Daßler-Plenker, P Guerci, A Weber, M Egeblad, +13 Additional Authors

Journal Articles

No abstract provided.

The Role Of Chest Imaging In Patient Management During The Covid-19 Pandemic: A Multinational Consensus Statement From The Fleischner Society., Gd Rubin, Cj Ryerson, Lb Haramati, N Sverzellati, Jp Kanne, S Raoof, Nw Schluger, A Volpi, J-J Yim, L Richeldi, +15 Additional Authors

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No abstract provided.

Analytical And Clinical Comparison Of Three Nucleic Acid Amplification Tests For Sars-Cov-2 Detection., E Smith, W Zhen, R Manji, D Schron, S Duong, Gj Berry

Journal Articles

No abstract provided.

Characteristics, Cardiac Involvement, And Outcomes Of Multisystem Inflammatory Disease Of Childhood (Mis-C) Associated With Sars-Cov-2 Infection., Ca Capone, A Subramony, T Sweberg, J Schneider, S Shah, L Rubin, C Schleien, S Epstein, Jc Johnson, A Kessel, N Misra, E Mitchell, N Palumbo, S Rajan, J Rocker, K Williamson, Kw Davidson

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No abstract provided.

Covid-19 Leading To Acute Encephalopathy In A Patient With Heart Transplant., K Jang, A Khatri, Dt Majure

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No abstract provided.