Medicine and Health Sciences Commons^™

Pacemaker Implantation In Patient With Persistent Left Superior Vena Cava And Absent Right Superior Vena Cava., Syed Rafay Ali Sabzwari, James R. Kimber, Sara Godil Md, Waqas Khan, Jawad Mir

Cardiology Division

Persistent left superior vena cava (LSVC) is an asymptomatic congenital heart disease. It is usually found incidentally on imaging, during central line placements or while undergoing electrophysiological procedures. We present a case of a 91-year-old female who initially presented with seizures and was diagnosed with tachy-brady syndrome. She was planned to undergo dual-chamber permanent pacemaker placement. However, during the procedure, she was incidentally found to have an LSVC without a right superior vena cava. Due to challenging anatomy, her pacemaker was changed to a single-chamber atrial lead pacemaker. This case highlights the clinical implications of this unusual structural anomaly, technical …

Ccne1 Amplification As A Predictive Biomarker Of Chemotherapy Resistance In Epithelial Ovarian Cancer, Justin W. Gorski, Frederick R. Ueland, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

Ovarian cancer is the most-deadly gynecologic malignancy, with greater than 14,000 women expected to succumb to the disease this year in the United States alone. In the front-line setting, patients are treated with a platinum and taxane doublet. Although 40-60% of patients achieve complete clinical response to first-line chemotherapy, 25% are inherently platinum-resistant or refractory with a median overall survival of about one year. More than 80% of women afflicted with ovarian cancer will recur. Many attempts have been made to understand the mechanism of platinum and taxane based chemotherapy resistance. However, despite decades of research, few predictive markers of …

Using Art As Therapy With Older Adults To Foster Connections And Establish Community Literature Review, Melissa Uva

Expressive Therapies Capstone Theses

This literature review advocates for the general needs of the growing aging population and focuses on how art as therapy programming can best support those needs. Arts programming, with an art therapy-inspired lens, can address the many needs of the older adult population and may promote meaningful connections between (1) the client and the art materials, (2) the client and self (both current and former), (3) the client and the facilitator/therapist, (4) the client and dyad or small groups and (5) the client and the community. The power of art therapy practices serves as the framework of this literature review, …

Embodied Transformation: A Review Of Play And Dance Movement Therapy For Complex Post-Traumatic Stress Disorder, Kaiyue Chen

Expressive Therapies Capstone Theses

This thesis explores the potential role of play and playfulness in dance movement therapy (DMT) for the treatment of complex post-traumatic stress disorder (CPTSD), which results from exposure to complex trauma. As its name suggests, CPTSD symptoms can be more severe than that of PTSD, and the prevalence of CPTSD is estimated at 3.8% of the U.S. population (Cloitre et al., 2019). Given these factors, this mental health issue warrants further research and treatment support. Towards this end, a critical review of the literature on the topics of complex trauma/CPTSD, play, and DMT has been conducted. Based on a synthesis …

Co-Leadership In Dance/Movement Therapy: An Art-Based Literature Review, Siyao Li

Expressive Therapies Capstone Theses

The co-leadership model is an unseen thread in the current picture of the field of dance movement therapy (DMT). Even if it’s deeply rooted in the development of the field, its significance for the current context of culture-informed and evidence-based practice is still under-investigated. This thesis sheds light on the importance of co-leadership in DMT through a historical review of the development of the field, the rationale of using co-leadership in DMT from neuroscientific, psychological and practical perspectives, and a synthesis of empirical studies on effectiveness of co-leadership in DMT. Co-leadership is a tradition in the field of DMT which …

Labyrinth Meditation As A Foundation For Photography With Adolescents, Corrie Vanderbrug

Expressive Therapies Capstone Theses

Abstract

This capstone thesis paper analyzes how the use of meditation, finger labyrinths, and photography intertwine to strengthen reflection for the adolescent population. To further this community engagement project, the researcher observed two male adolescents in in their work with meditation and photography. Results revealed that after the use of labyrinth meditation, participants felt calm and quiet. The photo-taking portion of this study was different than what they had previously experienced while taking images. Results also showed that meditation before photo-taking allowed for reflection, awareness, and personal empowerment to increase during the art making process. This study emphasizes the need …

Understanding Pediatric Injury In Collier County, Florida: A Mixed Methods Analysis, Carmen T. Ramos-Irizarry

Florida Public Health Review

Background: The current trauma system in Collier County disperses injured pediatric patients to trauma centers outside the County. There is a critical gap in knowledge in the epidemiology of the County’s pediatric trauma patients.

Purpose: To understand injury patterns in children ages 0-17 years in Collier County and identify challenges in transporting injured children to definitive care.

Methods: This is a cross sectional, descriptive study using a sequential mixed-methods design. A thorough review of the literature and interviews of key stakeholders were conducted in August 2017. Data obtained from the interviews was used to develop a causal loop diagram …

2020-05-05 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Alex Castillo Smith, Anistasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Ryen Ormesher, Samantha Paltrow-Krulwich, Stephen Esquerra, Allison Price, Jenny Situ, Aly Raboff, Ryota Shimada, Ariel Hurwitz, Alexandra Yingling, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM cases. Navajo cases. NM remdesivir inaccessible. Infected prison staff. No early prison releases. Unemployment beats working. NM $97M food benefits. UNM $50M revenue loss. Meat packer testing. Fall school reopening planning. Gym/salon reopening plans. 91k absentee ballots. Santa Fe closes polling stations. NM oil/gas pollution oversight. Prisons vulnerable. WH rejects FEMA report. Schools plan reopening. Italian mafia concerns. UK overtakes Italy. Symptom tracker early warning. Ethanol for FFP2 masks. Counterfeit masks. Mask skin damage. Mutant coronavirus more contagious. Hospital contamination zones. Disease prevalence estimation. Successful control measures. Average contagious period. Genetic epidemiology. Managing healthcare resources. Exercise and …

Staff Training In Aquatics For Individuals With Disabilities: The Quest, Susan J. Grosse

International Journal of Aquatic Research and Education

Trained instructors in general programs have the ability and resources to initiate and follow through with developing water safe individuals who are capable swimmers. Specific staff training to prepare individuals to facilitate aquatic participation for individuals with disabilities is currently extremely limited. The purpose of this article is to examine the barriers to specialized staff training in aquatics for individuals with disabilities, to suggest necessary staff training content, and to propose topics for further research in the area of staff training. Seeking development of quality staff training programs for those working in aquatics for individuals with disabilities is the quest.

The Bioethical Implications Of Genetic Screening Programs For Rare Diseases, Ellie Pitcher, Jeremy Mccallum

Honors Thesis

In the United States, there are currently thirty-five hereditary medical disorders that the Department of Health and Human Services recommends for newborn screening. The early diagnosis of these disorders is critical to the health and well-being of affected individuals. There are many more rare genetic diseases that would benefit from early diagnosis, but which do not symptomatically present until late in life or have low penetrance. Some of these genetic diseases are extremely dangerous, and would massively benefit from the early diagnosis that accompanies newborn screening in the United States. Here the benefits and risks associated with early screening for …

Contraceptive Care In South Carolina At Publicly Funded Family Planning Clinics, Center For Applied Reasearch And Evaluation In Women's Health, East Tennessee State University

Center for Applied Research and Evaluation (CARE) in Women's Health Resources

No abstract provided.

Analysis Of Different Characteristics Of Smile, Mehwish Khan, Syed Murtaza Raza Kazmi, Farhan Raza Khan, Imran Samejo

Section of Dental-Oral Maxillofacial Surgery

Introduction: Analysis of smile is imperative in the diagnosis and treatment planning phases of aesthetic dentistry.
Aim: To evaluate the components of smile among students of a dental institution.
Methods: Frontal view digital photographs with posed smile of 157 dental students were assessed using Adobe Photoshop7.0. Smile characteristics evaluated included; smile line, smile arc, smile design, upper lip curvature, labiodental relationship and number of teeth displayed. Data were analyzed using SPSS version 23.0. Pearson chi-square test was used to determine the gender based differences for various parameters.
Results: Average smile line (43.3%), consonant smile arcs (45.2%), cuspid smiles (45.9%), upward …

Anti-Signal Recognition Particle Antibody-Associated Severe Interstitial Lung Disease Requiring Lung Transplantation., Anam Qureshi, Daniel F. Brown Md, Lawrence Brent

Department of Pathology & Laboratory Medicine

Anti-signal recognition particle (SRP) antibodies are typically associated with immune-mediated necrotizing myopathy. Some patients with anti-SRP antibodies may have extramuscular manifestations including mild respiratory symptoms secondary to interstitial lung disease. We present a case of a 40-year-old female presenting with acute hypoxic respiratory failure secondary to anti-SRP antibody-associated interstitial lung disease with mildly elevated creatinine kinase but without evidence of necrotizing myopathy on muscle biopsy. After a complicated six-month hospitalization, the patient successfully received double lung transplantation and was eventually discharged on room air. Unexplained worsening interstitial infiltrates leading to persistent hypoxic respiratory failure in the setting of nonspecifically elevated …

Applying Modern Immunology To The Plague Of Ancient Athens, Juhi C. Patel

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

During the 5^th century BCE, ancient Athens and Sparta were involved in a major war during which an epidemic disease broke out in Athens, claiming the lives of a substantial part of the population. Although the ancient Greek historian Thucydides provides a first-hand account of the symptoms of the plague, modern historians have not been able to definitively identify the pathogen that caused the deadly epidemic. In 1994, a burial tomb of Athens was unearthed that unveiled the likely remains of plague victims. In 2005, scientists conducted molecular testing on the dental remains and used suicide PCR to compare …

The Current Neuroscientific Understanding Of Alzheimer's Disease, Rachel A. Brandes

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Alzheimer’s disease is a degenerative neurological illness characterized by the deterioration of brain regions implicated in memory and cognitive function. While researchers have yet to find a cure or effective treatment, they have gained a better understanding of its pathology and development. Through years of neuroscience research, scientists have discovered much of what happens in the brain during Alzheimer’s disease onset and how this causes its symptoms; many hypotheses regarding this aspect of the illness involve temporal lobe atrophy, neurofibrillary tangles, and amyloid plaques. Although Alzheimer’s disease affects millions of people every day, it seems that most are unaware of …

2020-05-04 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-05-04_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-05-04_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

MDHHS has established a regional hub strategy to assist in reducing the spread of COVID-19 within nursing facilities. COVID-19 Regional Hubs have established units dedicated to treating COVID-19-affected individuals and have established appropriate staffing levels and protocols to support this level of care.
These case counts reflect current cases of COVID-19 among facility residents reported …

2020-05-04_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

2020-05-04_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Histone Deacetylase 1 And 2 Drive Differentiation And Fusion Of Progenitor Cells In Human Placental Trophoblasts, Gargi Jaju Bhattad, Mariyan J. Jeyarajah, Megan G. Mcgill, Vanessa Dumeaux, Hiroaki Okae, Takahiro Arima, Patrick Lajoie, Nathalie G. Bérubé, Stephen J. Renaud

Paediatrics Publications

Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue, facilitates nutrient and gas exchange, and produces hormones vital for pregnancy. Syncytiotrophoblast development occurs by differentiation of underlying progenitor cells called cytotrophoblasts, which then fuse into the syncytiotrophoblast layer. Differentiation is associated with chromatin remodeling and specific changes in gene expression mediated, at least in part, by histone acetylation. However, the epigenetic regulation of human cytotrophoblast differentiation and fusion is poorly understood. In this study, we found that human syncytiotrophoblast …

Depressed Neuromuscular Transmission Causes Weakness In Mice Lacking Bk Potassium Channels, Xueyong Wang, Steven R.A. Burke, Robert J. Talmadge, Andrew A. Voss, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

Mice lacking functional large-conductance voltage- and Ca2+-activated K+ channels (BK channels) are viable but have motor deficits including ataxia and weakness. The cause of weakness is unknown. In this study, we discovered, in vivo, that skeletal muscle in mice lacking BK channels (BK−/−) was weak in response to nerve stimulation but not to direct muscle stimulation, suggesting a failure of neuromuscular transmission. Voltage-clamp studies of the BK−/− neuromuscular junction (NMJ) revealed a reduction in evoked endplate current amplitude and the frequency of spontaneous vesicle release compared with WT littermates. Responses to 50-Hz stimulation indicated a reduced probability of vesicle release …

2020-05-04_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

The Comparison Of Endothelial Permeability At 48 Hours Post Skeletal Muscle Injury In Male And Female Mice At Various Ages, Sabrina Tusavitz

Health Sciences Honors Papers

We compared endothelial permeability at 48 hours post skeletal muscle injury in male and female mice at 1 month, 2 months, 3, 6 and 12 months of age. We hypothesized that the female mice would show more permeability at 48 hours post injury than the male mice at all ages. Our findings were more complicated as permeability following injury trends down with age in females, and up with age in males. These findings could be beneficial for medical professionals to tailor an injured athlete’s treatment to their age and sex since there are permeability and therefore possibly inflammation differences.

The Time Course Of Moral Perception: An Erp Investigation Of The Moral Pop-Out Effect, Ana Gantman, Sayeed Devraj-Kizuk, Peter Mende-Siedlecki, Jay J. Van Bavel, Kyle E. Mathewson

Publications and Research

Humans are highly attuned to perceptual cues about their values. A growing body of evidence suggests that people selectively attend to moral stimuli. However, it is unknown whether morality is prioritized early in perception or much later in cognitive processing. We use a combination of behavioral methods and electroencephalography to investigate how early in perception moral words are prioritized relative to non-moral words. The behavioral data replicate previous research indicating that people are more likely to correctly identify moral than non-moral words in a modified lexical decision task. The electroencephalography data reveal that words are distinguished from non-words as early …

Treating Trauma: The Occupational Therapy Perspective, Matthew Althaver

Honors Projects

Holistic health trends are increasing in the field of healthcare. The current research examines holistic trends in trauma treatment. Furthermore, it specifically looks at what occupational therapists can do to treat trauma. Survey results provide insight into occupational therapists' views on holistic health and trauma treatment. Overall, therapists bought into the concept of holistic health. Specific characteristics, like the length of time practicing OT, had an effect on their holistic health views.

Gaming Intentionally: A Literature Review Of The Viability Of Role-Playing Games As Drama-Therapy-Informed Interventions, Jonathan Mendoza

Expressive Therapies Capstone Theses

Tabletop role-playing games (TTRPGS) and live-action role-playing (LARP) games have recently risen in popularity in the cultural zeitgeist with the advent of popular gaming shows like Critical Roll and The Adventure Zone, as well as popular media like Community and Stranger Things. While some literature exists linking the concepts of roleplaying to theater and psychotherapy in the pursuit of deeper game design, little exists that attempts to bridge the gap by examining the potential of role-playing games (RPGs) as therapeutic tools informed by drama therapy practices and theories. This literature review provides a brief overview of basic RPG …

Ada News - 05/04/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Youth Violence Prevention In Florida: A Commentary, Yingwei Yang

Florida Public Health Review

No abstract provided.

Gut Microbiome-Modified Polyphenolic Compounds Inhibit Α-Synuclein Seeding And Spreading In Α-Synucleinopathies, Tritia R. Yamasaki, Kenjiro Ono, Lap Ho, Giulio M. Pasinetti

Neurology Faculty Publications

Misfolding, aggregation and deposition of α-synuclein (α-syn) are major pathologic characteristics of Parkinson’s disease (PD) and the related synucleinopathy, multiple system atrophy (MSA). The spread of α-syn pathology across brain regions is thought to play a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that target and attenuate α-syn aggregation and spread. Recent studies of brain-penetrating polyphenolic acids, namely, 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-(3-hydroxyphenyl)propionic acid (3-HPPA) that are derived from gut microbiota metabolism of dietary polyphenols, show in vitro ability to effectively modulate α-syn misfolding, oligomerization, and …