Medicine and Health Sciences Commons^™

Ergonomic Trends In Endoscopic Skull-Base Surgeons: A Survey To The North American Skull Base Society, Shreya Mandloi, Alexander Duffy, Praneet Kaki, Elina Toskala, Marc Rosen, Christopher Farrell, James Evans, Gurston G. Nyquist, Mindy Rabinowitz, Md

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVE: Lack of ergonomic practices in the operating room results in significant musculoskeletal strain. This study obtains a current assessment of self-reported musculoskeletal strain associated with endoscopic endonasal and open skull base surgery as reported by members of the North American Skull Base Society (NASBS).

STUDY DESIGN: Online Survey.

SETTING: Online.

METHODS: A survey assessing current symptoms in endoscopic skull base surgery was distributed to members of the NASBS.

RESULTS: Sixty-six responses were completed and analyzed. 95% of respondents indicated they had musculoskeletal strain at the neck and C-spine. There was no significant difference in average operating time per week …

Ergonomic Trends In Endoscopic Skull-Base Surgeons: A Survey To The North American Skull Base Society, Shreya Mandloi, Alexander Duffy, Praneet C. Kaki, Elina Toskala, Marc Rosen, Christopher Farrell, James J. Evans, Gurston G. Nyquist, Mindy R. Rabinowitz

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVE: Lack of ergonomic practices in the operating room results in significant musculoskeletal strain. This study obtains a current assessment of self-reported musculoskeletal strain associated with endoscopic endonasal and open skull base surgery as reported by members of the North American Skull Base Society (NASBS).

STUDY DESIGN: Online Survey.

SETTING: Online.

METHODS: A survey assessing current symptoms in endoscopic skull base surgery was distributed to members of the NASBS.

RESULTS: Sixty‐six responses were completed and analyzed. 95% of respondents indicated they had musculoskeletal strain at the neck and C‐spine. There was no significant difference in average operating time per week …

Rural–Urban Differences In Cognitive Outcomes Among Older Adults: The Roles Of Falls And Depressive Symptoms, Ayse Malatyali, Tom Cidav, Lisa A.K. Wiese, Jian Zou, Monique J. Brown Ph.D., Mph, Junfeng Ma, Breno S. Diniz, Ladda Thiamwong

Faculty Publications

Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the association of falls and depressive symptoms with cognitive impairment and dementia in a nationally representative sample. Methods: We analyzed data from 6221 participants (age ≥ 65) in the Health and Retirement Study (HRS) from the 2018–2020 waves, using Multinomial logistic regression models. Measures included the HRS health status questionnaire, HRS cognition scale, and the Center for Epidemiological Studies Depression scale. Results: Prevalence of fall exposure across …

Rural–Urban Differences In Cognitive Outcomes Among Older Adults: The Roles Of Falls And Depressive Symptoms, Ayse Malatyali, Tom Cidav, Lisa A.K. Wiese, Jian Zou, Monique J. Brown Ph.D., Mph, Junfeng Ma, Breno S. Diniz, Ladda Thiamwong

Faculty Publications

Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the association of falls and depressive symptoms with cognitive impairment and dementia in a nationally representative sample. Methods: We analyzed data from 6221 participants (age ≥ 65) in the Health and Retirement Study (HRS) from the 2018–2020 waves, using Multinomial logistic regression models. Measures included the HRS health status questionnaire, HRS cognition scale, and the Center for Epidemiological Studies Depression scale. Results: Prevalence of fall exposure across …

Dual Phagocytosis-Checkpoint Blockade Revitalizes Immune Surveillance In Mouse Models Of Glioblastoma, Jonghoon Ha, Yifan Wang, Yifan Ma, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L Edwards, Mengyu Chang, Yen-Tzu Chang, Xiaotian Wang, Maurice Dufilho, Michelle Najarro Torres, Shannon Mccabe, Weiye Deng, Adam J Grippin, Jeffrey S Weinberg, Shaan M Raza, Franco Demonte, Ian E Mccutcheon, Sujit Prabhu, Sherise D Ferguson, Chibawanye I Ene, Kadir Akdemir, Sreyashi Basu, Sonali Jindal, Benjamin R Schrank, Jian Hu, Sangeeta Goswami, Vinay K Puduvalli, Frederick F Lang, Kristin Huntoon, Padmanee Sharma, Betty Y S Kim, Wen Jiang

Faculty, Staff and Student Publications

Macrophage-mediated phagocytosis of tumor cells elicits potent antitumor immunity. Nonetheless, sole-blockade of the anti-phagocytosis molecule CD47 has yielded insufficient therapeutic outcomes. Here, we report that glioblastoma (GBM) cells expressed abundant levels of phagocytosis checkpoint CD24. We further show that dual blockade of CD24 and CD47 synergistically enhances the pro-phagocytic activity of macrophages, thereby improving tumor antigen cross-presentation and activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. This innate immune activation facilitates T cell infiltration into tumors and sensitizes tumors to anti-PD1 therapy, improving survival outcomes in murine GBM models, including immunosuppressive tumors reflecting human GBM-like features. Thus, our …

A Case Of Autosomal Dominant Polycystic Kidney Disease With Multiple Bilateral Spontaneous Retroperitoneal Hemorrhages, Masato Mizuta, Tatsuya Suwabe, Yuki Oba, Akinari Sekine, Masayuki Yamanouchi, Hiroki Mizuno, Eiko Hasegawa, Takehiko Wada, Makoto Fukuda, Motoaki Miyazono, Naoki Sawa, Yoshifumi Ubara

Children’s Nutrition Research Center Staff Publications

We experienced a 45-year-old male with ADPKD who developed spontaneous retroperitoneal hemorrhages with hypertension in the right subcapsular renal space without trauma. After his condition worsened with conservative management, he was treated by renal transarterial embolization (TAE). Over the next eight years, he experienced bilateral bleeding at three different sites and underwent repeated endovascular treatment with renal TAE to stop the bleeding. After the fourth occurrence, the patient underwent hemodialysis. Although renal cysts and urinary tract bleeding occur frequently in ADPKD, retroperitoneal hemorrhage is rare; however, TAE is both effective and a good way to preserve renal function.

Patient And Healthcare Professionals' Perceptions Of Educational Tools To Reduce Urine Culture Contamination In Outpatient Clinics: A Qualitative Study., Ashley Collazo, Trenton M Haltom, Johanan Luna Rodriguez, Kiara Olmeda, Azalia Mancera, Fabrizia Faustinella, Michael K Paasche-Orlow, Zach Landis-Lewis, Roger Zoorob, Barbara W Trautner, Larissa Grigoryan

2020-Current year OA Pubs

OBJECTIVE: Iteratively develop educational tools (instructional video and flyer) to improve midstream clean catch (MSCC) urine sample collection using patient and healthcare professionals' input.

DESIGN: Multi-method qualitative study.

SETTING: Outpatient clinics in Houston, Texas, United States.

PARTICIPANTS: Adult patients recruited from public and private clinics (

METHODS: Twelve patient interviews and three focus groups with HCPs (May 2024-November 2024). Interviews discussed patient experiences using the educational tools to guide urine specimen collection. Focus groups elicited HCPs' perspectives on the comprehensibility and utility of the tools in their respective clinics. We identified themes using directed content analysis.

RESULTS: We garnered insight …

Late Local Recurrence Of Gastric Cancer After Preoperative Radiochemotherapy: Three Case Reports And Literature Review, Mateusz M. Gajek, Magdalena Szymala-Cortez, Jerzy Wydmański

Pacific Journal of Health

Gastric cancer (GC) ranks as the fifth most common cancer type, contributing significantly to cancer-related mortality. This paper presents three cases of patients treated with preoperative radiochemotherapy (preopRTCT) at the National Cancer Center who experienced recurrences of GC after 15, 11 and 19 years. In all cases follow-up ended years before recurrence. Relapse was diagnosed late and treatment outcome was poor. We believe that extending the follow-up period for gastric cancer patients beyond the initial treatment is necessary especially for younger patients with large tumors. Late recurrences, often diagnosed at advanced stages, require differentiation from second primary malignancies, a process …

Camouflage Orthodontic Treatment Of Skeletal Class Ii Malocclusion With Missing Mandibular Incisors Using Improved Superelastic Ti–Ni Alloy Wire, Pin-Yu , Chen, Yuan-Hou Chen, Yuan-Hou Chen, Jian-Hong Yu

Taiwanese Journal of Orthodontics

This article presents a camouflage orthodontic treatment utilizing the improved superelastic Ti-Ni alloy wire (ISW) to address a case of skeletal Class II malocclusion with two missing mandibular incisors. A 28-year-old female patient with a chief complaint of poor dental alignment sought orthodontic evaluation. Clinical examination revealed a Class III molar relationship, mild crowding, and lingually positioning of tooth 35. Radiographic analysis confirmed a skeletal Class II pattern. The treatment plan included the application of an ISW curve over the maxillary arch to control anterior tooth inclination. Canine distal drive and anterior retraction were performed following the extraction of bilateral …

Interdisciplinary Orthodontic Management Of Class Ii Severe Hypodontia Using Improved Super-Elastic Ti-Ni Alloy Wire, Hsuan Jeng, Yuan-Hou Chen, Jian-Hong Yu

Taiwanese Journal of Orthodontics

This case report presents the orthodontic management of a 23-year-old male with severe hypodontia, specifically the congenital absence of all premolars and bilateral peg laterals. The patient sought treatment due to dissatisfaction with previous orthodontic outcomes, characterized by noticeable spacing in the upper anterior region. Clinical evaluation revealed a skeletal Class II relationship and several dental anomalies, prompting the need for an interdisciplinary approach.

The patient was treated using an improved super-elastic Ti-Ni alloy wire (ISW), which provided consistent light continuous forces, high elasticity, and super-elastic properties beneficial for controlling tooth movement in patients with missing teeth and anchorage limitations. …

Long-Term Interdisciplinary Management Of Severe Vertical Bony Defects Using Periodontal Accelerated Osteogenic Orthodontics (Paoo), Chun-Han Su, Huei-Mei Tsai, Yi-Min Liu, Yuen-Yung Tsang, Yu-Ling Cheng

Taiwanese Journal of Orthodontics

Background: Management of severe malocclusion in patients with chronic periodontitis poses significant challenges due to compromised periodontal support and alveolar bone loss. Periodontally accelerated osteogenic orthodontics (PAOO) may facilitate tooth movement while promoting bone regeneration in such cases.

Case presentation: A 33-year-old male with chronic periodontitis and severe malocclusion presented for orthodontic correction. Initial treatment included comprehensive periodontal therapy—oral hygiene control, open-flap debridement, and bone grafting—prior to orthodontic intervention. Congenital absence of tooth 12 resulted in mesial drift, and teeth 17, 24, and 27 were extracted due to poor prognosis. Despite initial periodontal improvement, inflammation and labial plate collapse at …

Correction Of Facial Asymmetry Using Bilateral Sagittal Split Osteotomy Combined With Anterior Mandibular Midline Split And Genioplasty, Po-Yu Yang, Chia-Tze Kao, Yi-Chieh Chen, Wen-Ken Tai

Taiwanese Journal of Orthodontics

Facial asymmetry accounts for approximately two-thirds of orthognathic surgical patients and may involve discrepancies in any of the three spatial planes. Conventional bilateral sagittal split osteotomy (BSSO) has limitations in correcting patients with significant discrepancies in bilateral ramus angles. This paper proposes a novel surgical approach for the correction of facial asymmetry using BSSO combined with an anterior midline mandibular split osteotomy and genioplasty.

A 30-year-old woman presented with a skeletal Class III pattern, occlusal canting, and a 3-mm deviation of the chin to the right. Intraoral examination revealed an anterior crossbite, dental midline deviation, and a left Angle’s Class …

An Ai-Assisted Digital Workflow For Clinical Planning And Guide Fabrication In Miniscrew-Assisted Rapid Palatal Expansion, Yu-Chiang Chen, Szu-Ching Lee, Ting-Fen Chang, Wei-Lun Chang, Shu-Cheng Lin, Tzu-Ying Wu

Taiwanese Journal of Orthodontics

Purpose: This article introduces a digital workflow for creating a miniscrew-assisted rapid palatal expander (MARPE) guide, to virtually determine the proper MARPE position and to precisely transfer it into the reality. Materials and Methods: A digital workflow was established by the following steps: (1) generating a digital model with palatal soft tissue from the digital scan, (2) isolating teeth on the digital model from the CBCT file for band size try-in using AI software (DentalSegmentator), (3) constructing a model with four parallel cylinders simulating the MARPE screws’ pathways, (4) superimposing the three models to determine the proper MARPE position, (5) …

To Extract Or Not To Extract: On What Basis Do We Make That Decision? (Part Ii), Ib Leth Nielsen

Taiwanese Journal of Orthodontics

The most common extraction pattern in orthodontic patients with crowding of the teeth is the four first bicuspids. This is usually done in cases with severe crowding or bimaxillary protrusion. In some instances, orthodontists have decided, instead of extracting the first bicuspids, to extract the second bicuspids, for various reasons that we shall discuss in this review. Several other extraction patterns have also been implemented in the past, including second molars, lower incisors, and even asymmetric extractions. In this review, we shall discuss the pros and cons of each of these choices. In some patients, clinicians have even decided to …

Heat And Socioeconomic Deprivation Compound To Drive Coronary Heart Disease In Los Angeles, Shutong Huo, Tessa R. Pulido, Reginald S. Archer, Joshua B. Fisher, Jason A. Douglas

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Background:

Socioeconomic deprivation and environmental heat exposure each increase cardiovascular risk, yet evidence is limited on how these stressors co-occur and jointly shape disease burden within cities. Mapping their overlap can inform equity-oriented planning and needs-based allocation of health and social protection resources.

Methods:

We conducted an ecological geospatial analysis of 2,513 census tracts in Los Angeles County. Adult coronary heart disease (CHD) prevalence was obtained from CDC Population Level Analysis and Community Estimates (2021). Socioeconomic deprivation was measured using the Social Deprivation Index (SDI), and heatwave surface heat hazard was measured using land surface temperature (LST) retrieved from the …

Association Between Bmi Z-Score And Postoperative Complications In Pediatric Neuromuscular Scoliosis Surgery, Alexander K Mihas, Dion Birhiray, Chun Wai Hung, Lorenzo R Deveza, Dallas Vanorny, Frank Gerow, Darrell Hanson, Benny Dahl

Faculty, Staff and Students Publications

Study Design

Single-center retrospective review.

Objective

To investigate the association between BMI Z-scores and postoperative complications in pediatric patients with neuromuscular scoliosis undergoing spinal instrumentation.

Methods

Pediatric patients who underwent spinal instrumentation for neuromuscular scoliosis from July 2012 to June 2016 with a minimum 2-year follow-up were included. BMI and BMI Z-scores were calculated, and patients were stratified into CDC-defined BMI-for-age percentiles: underweight (< 5th percentile), normal (5th to < 85th percentile), overweight (85th to < 95th percentile), and obese (≥95th percentile). Logistic regression assessed associations of BMI, BMI Z-score, and BMI groups with postoperative complications.

Results

In total, 147 patients were included. Average follow-up was 3.2 ± 1.4 years. The most common diagnosis was cerebral palsy (39.5%). Complications occurred in 65 (44.2%) patients: 32 (21.8%) had a surgical site infection (SSI), …

Microrna-625-3p Increases Chemosensitivity In Ovarian Cancer Cells Through Decreasing Ssx2ip-Mediated Cisplatin Export In Extracellular Vesicles, Chi-Lam Au-Yeung, Tetsushi Tsuruga, Marina A Talor, Yadira J Pacheco, Guangan He, Zahid H Siddik, Byeong J Cha, Suet-Ying Kwan, Kwong-Kwok Wong, Kay-Pong Yip, Samuel C Mok

Faculty, Staff and Student Publications

Introduction: Advanced-stage high-grade serous ovarian cancer (HGSC) is a disease that is difficult to manage due to its heterogeneous clinical behavior. No reliable prediction of response to chemotherapy is currently available and the overall survival rate remains poor. Herein, we sought to determine the molecular mechanisms by which microRNAs (miRNAs) confer chemoresistance in ovarian cancer and demonstrate the efficacy of targeting miRNAs to sensitize HGSC to cisplatin treatment.

Methods: Next-generation miRNA sequencing was performed using microdissected HGSC specimens to identify an miRNA signature for intrinsic chemoresistance, and miR-625-3p was selected for further study. The effects of miR-625-3p on cisplatin sensitivity …

Waste-To-Energy Innovations And Advances In Hydrothermal Carbonization, Microwave, And Pyrolysis Processes: A Review, Ali Mohammed Saleh, Noah Mohammed Saleh, Mahmod A. Abdulqader, Hadi Hamdi Mahdi, Jafar Keighobadi, Omar K. Ahmed, Khalil Farhan Yassin, Azil Bahari Bin Alias, Omar Abed Habeeb, Ibrahim Awad Mohammed

AUIQ Complementary Biological System

The accelerating global generation of municipal solid waste, coupled with escalating energy demands, presents one of the most pressing sustainability challenges of the 21st century. Conventional waste disposal pathways, such as landfilling and incineration, exacerbate environmental degradation and resource loss. In response, thermochemical technologies—specifically hydrothermal carbonization (HTC), microwave-assisted processing, and pyrolysis—have emerged as promising strategies for waste valorization and renewable energy recovery. This review critically examines recent advancements in these technologies, emphasizing their roles in converting diverse waste streams into high-value energy carriers and carbon-rich materials. Comparative analysis reveals that HTC operates efficiently under subcritical water conditions, producing hydrochar with …

Role Of Continuous Positive Airway Pressure In The Prevention Of Cardiovascular Events In Patients With Obstructive Sleep Apnea: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials, Saif Almuzainy, Mohamed Lemine, Rayan Aljubeh, Ahmad Alilo, Maryam Altaher, Mohamed Almuzainy, Sami Alsalem, Mohamed Dawdi

Journal of the Saudi Heart Association

Background: Obstructive sleep apnea (OSA) is prevalent among patients with cardiovascular disease and is associated with increased risk of major adverse cardiovascular events (MACE). Continuous positive airway pressure (CPAP) is the standard treatment for OSA, but its impact on cardiovascular outcomes remains uncertain, particularly in randomized controlled trials (RCTs).

Objectives: To evaluate the effect of CPAP therapy on cardiovascular outcomes in patients with OSA, and to explore the influence of adherence on treatment efficacy.

Methods: We conducted a systematic review and meta-analysis of RCTs comparing CPAP with placebo or usual care in adults with OSA. Databases including PubMed, Scopus, Ovid, …

Modeling The Impact Of Shade Pavilions On Wet Bulb Globe Temperature And Activity Modification In Outdoor Sports Across Diverse U.S. Climates, Andrew Grundstein, Susan W. Yeargin Ph.D., Atc, Lat, Earl Cooper, Lilly Cargile

Faculty Publications

Extreme heat is an ongoing hazard for outdoor sports. In response, schools, recreation departments, and fitness clubs are increasingly installing shade pavilions over venues like football fields and tennis courts. While shading is known to improve thermal comfort and reduce heat stress, its effects on wet bulb globe temperature (WBGT) and related activity modification guidelines in sports remain underexplored. This study uses a modeling approach to quantify the impact of shade pavilions on WBGT and activity modification across a range of U.S. climates.

WBGT values were calculated using a model based on historical data from 221 weather stations, each with …

Three-Dimensional Printing Of The Epineurium For Peripheral Nerve Repair: A Comprehensive Review Of Novel Scaffolds For Nerve Conduits, Alynah J. Adams, Iulianna C. Taritsa, Kaavian Shariati, Aaron Dadzie, Jose A. Foppiani, Maria Jose Escobar-Domingo, Daniela Lee, Angelica Hernandez-Alvarez, Kirsten Schuster, Helen Xun

School of Medicine Publications

Background: Nerve conduits are used to bridge peripheral nerve defects caused by trauma, iatrogenic injury, or oncologic disruption. Three-dimensional (3D) biomimetic scaffolds for peripheral nerve regeneration have advanced significantly in recent years, driven by improvements in printing technology and neuronal seeding techniques. We report on published designer conduits that can recreate the epineurium, a critical yet challenging-to-manufacture feature of nerve tissue.

Methods: A medical librarian conducted a literature search for our systematic review on EMBASE, Web of Science, and PUBMED, following PRISMA guidelines, for articles from January 2010 to January 2026 for the systematic review. Descriptive statistical analysis was performed …

Post-Traumatic Pituitary Stalk Transection Syndrome, Raya Albusaidi, Asma Alhatmi, Azza Al Shidhani, Eiman Al-Ajmi

Sultan Qaboos University Medical Journal

No abstract provided.

A Novel Laparoscopic Renal Denervation System In A Preclinical Swine Model, Linwei Zhao, Wei Yang, Binbin Zhu, Yahui Liu, Peng Tian, Xinyu Guo, Yang Dong, Zhiqiang Fan, Huiping Li, Yu Feng, Lijie Zhu, Minfu Bai, Qiuping Zhao, Xingkun Zhang, Chenchen Si, Qianqian Cheng, Gan-Xin Yan, Chuanyu Gao

Department of Medicine Faculty Papers

Laparoscopic renal denervation (RDN) represents a specialized approach for hypertension, particularly when conventional methods face limitations. While catheter-based RDN has demonstrated significant efficacy in recent large-scale clinical trials and has been integrated into international guidelines, its effectiveness can be constrained by complex renal anatomy or incomplete ablation. We developed a novel laparoscopic RDN system, comprising an integrated radiofrequency (RF) clamp, RF generator, and cooling pump, to achieve more controlled adventitial ablation. This study aims to evaluate the safety, feasibility, and optimal parameters of this new system in a preclinical swine model. Sixteen pigs were divided into an immediate group ( …

Kinetic Human Movement Ontology: A Semantic Terminology Model To Symbolically Represent Physiological Movement, Muhammad Amith, Vivian Ha, Eloisa Nguyen, Yang Gong, Ahsiya Lin, Cui Tao, Licong Cui

Faculty, Staff and Student Publications

Cataloging physiological and anatomical terminologies may provide a fundamental basis for bridging the involvement of muscles, skeletal, and other essential parts in human movement, in addition to understanding their role on human morbidity. We present a general formalized ontology model that focuses on anatomical and physiological entities that are active during human movement, called the Kinetic Human Movement Ontology (KHMO). We developed a model to represent human movement that links human postures using OWL2. We used the model to assemble various open-sourced controlled terminologies involved in human movement - anatomical entities, physiological terms, etc. KHMO presents 1954 classes, 42 properties, …

Operative Confidence In Open And Endovascular Procedures Among Vascular Surgery Graduates Reflects Procedural Exposure During Training, Jin Park, Nicola Habash, Dawn Salvatore, Michael Nooromid, Paul J. Dimuzio, Babak Abai

Department of Surgery Faculty Papers

Objective: The shift toward minimally invasive techniques has transformed vascular surgery practice and training. As endovascular procedures replace many traditional open operations, concerns have emerged about whether current training adequately prepares graduates for independent practice, particularly in complex open procedures.

Methods: A web-based survey was distributed to recent graduates of Accreditation Council for Graduate Medical Education-accredited vascular surgery training programs from 2022 and 2024. The survey assessed demographics, program characteristics, estimated case volumes, and confidence in 22 core vascular operations using a five-point Likert scale. Mann-Whitney U and Kruskal-Wallis tests, as well as multivariable logistic regression, identified factors associated with …

Integrating The Glycemia Risk Index Into Clinical Practice And Research: A Consensus Report, Guillermo E Umpierrez, Viral N Shah, Veronica Brady, Mark A Clements, Juan Espinoza, Elizabeth Healey, Michael A Kohn, David M Maahs, Ralph Oiknine, Jane J Seley, Steven P Weitzman, David Kerr, Halis K Akturk, Grazia Aleppo, Mohammed E Al-Sofiani, Eda Cengiz, Francis J Doyle, Osagie Ebekozien, Steven V Edelman, Laya Ekhlaspour, Guido Freckmann, Lutz Heinemann, Irl B Hirsch, Victoria C Hsiao, Sun H Kim, Boris Kovatchev, Rayhan A Lal, Marcus Lind, Julia K Mader, Nestoras Mathioudakis, Tracey Mclaughlin, Sultan A Meo, Deborah A Osafehinti, Moshe Phillip, Priya Prahalad, David Scheinker, Michael P Snyder, Jing Wang, Jenise C Wong, Eugene E Wright, Mandy M Shao, Agatha F Scheideman, Ashley Y Dunova, David C Klonoff

Faculty, Staff and Student Publications

A panel of experts in the use of continuous glucose monitoring (CGM) data in the treatment of diabetes met in Burlingame, California on October 27, 2025 to discuss the utility of the glycemia risk index (GRI) for clinical care research and population health management. The GRI composite metric is a single number (on a 0-100 percentile scale-lower is better) based on an expert-determined weighting of the seven individual components in the existing ambulatory glucose profile (AGP). The GRI describes the quality of glycemia based on glucose values collected in a 14-day CGM tracing, thus providing additional insights into CGM profiles …

Determining The Optimal Management Of Geriatric Type Ii Odontoid Fractures: A Comparative Network Meta-Analysis, Shaan Patel, Shiva A. Nischal, Kush M. Kale, Stavros Matsoukas, Joshua Heller, Jack Jallo, James S. Harrop, Srinivas K. Prasad

Department of Neurosurgery Faculty Papers

UNLABELLED: Type II odontoid fractures are the most common cervical injury in geriatric populations, yet optimal management remains debated. This study compared the safety and effectiveness of non-surgical management (NSM), anterior dens screw (ADS) fixation, and posterior arthrodesis (PA) in these patients. A systematic review and frequentist network meta-analysis was conducted according to PRISMA-NMA guidelines. PubMed/MEDLINE, Embase, and CENTRAL were searched from inception to October 2025. Comparative studies including patients ≥ 60 years with Anderson-D’Alonzo type II fractures and reporting at least one primary outcome (mortality, union, stable non-union, unstable non-union) were eligible. Random-effects network models generated pooled odds ratios …

Crossing The Finish Line Towards A Disease-Modifying Treatment For Angelman Syndrome, Matthew C Judson, Jason J Yi, Et Al.

2020-Current year OA Pubs

Recent progress in the development of genetic therapies promises that impactful treatments for single-gene neurodevelopmental disorders are imminent. But can derailed neurodevelopmental processes be mended after broken genes are replaced or otherwise restored? The results of ongoing clinical trials for Angelman syndrome will soon yield answers to this pressing question, yet the trials face significant obstacles. Here we identify insights needed to aid the quest for a disease-modifying Angelman syndrome therapy, which could serve as a roadmap for the expeditious development of genetic therapies for other single-gene neurodevelopmental disorders.

Blood And Body Fluid Exposure And Reporting Behaviors Among Healthcare Workers: A Decade-Long Comparative Study At A Tertiary Medical Center, Ziad Kaddour, Rami Abdul-Halim, Zeina Al-Khalil, Lea Al Zoghby, Raafat Alameddine, Reem Mansour, Jack El Sawda, Zeina A Kanafani

2020-Current year OA Pubs

BACKGROUND: Occupational exposure to blood and body fluids (BBFE) remains a significant risk for healthcare workers (HCWs), yet underreporting persists despite the implementation of institutional policies. This study aimed to compare BBFE prevalence, reporting practices, and HCWs' knowledge, perceptions, attitudes, and behaviors, and identify predictors of BBFE and failure to report incidents over a ten-year period at a tertiary medical center.

METHODS: Two cross-sectional surveys were conducted at the American University of Beirut Medical Center (AUBMC) in 2013-2014 and 2023-2024. In 2013-2014, all participants completed paper-based questionnaires, whereas in 2023-2024, medical students, residents, and nurses completed online surveys, and housekeeping/laundry …

Pelvic Health: Lived Experience, Needs And Resources For Women With Pelvic Organ Prolapse, Louise Carroll, Catherine Doody, Cliona O’ Sullivan, Carla Perrotta, Brona M. Fullen

Women+ in Early Career Research Symposium

Pelvic organ prolapse (POP) affects up to 50% of women and can substantially impact physical function, psychological wellbeing, and quality of life. Despite its prevalence, gaps remain in understanding the experiences and support needs of reproductive-age women, particularly within the Irish healthcare context. This thesis aimed to explore the lived experience of women with POP, examine knowledge and care gaps among women and healthcare professionals (HCPs), and develop an intervention to support self- management. A mixed-methods approach was used. A systematic review identified limitations in the use of patient-reported outcome measures (PROMs) and highlighted opportunities to better capture biopsychosocial characteristics …