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Articles 8221 - 8250 of 324831

Full-Text Articles in Medicine and Health Sciences

Endometriosis Knowledge Among Emergency Medicine Providers: Diagnostic Skills And Symptom Recognition, Caidon Iwuagwu, Laurel X. Chen, Ellen Slattery, Pranjal Srivastava, Hamsitha Karra, Sheyenne Tung, Adrienne Burton, Camila Bomtempo, Jamie Aranda Mar 2026

Endometriosis Knowledge Among Emergency Medicine Providers: Diagnostic Skills And Symptom Recognition, Caidon Iwuagwu, Laurel X. Chen, Ellen Slattery, Pranjal Srivastava, Hamsitha Karra, Sheyenne Tung, Adrienne Burton, Camila Bomtempo, Jamie Aranda

Department of Surgery Faculty Papers

Objective: Endometriosis is associated with significant diagnostic delays, averaging 6.7 years, largely due to nonspecific symptoms and inadequate diagnostic approaches. Over 15,000 emergency department (ED) visits in the United States annually involve patients with endometriosis, highlighting the need for knowledge of endometriosis. This study surveys emergency medicine (EM) attendings, residents, nurse practitioners, physician assistants, and fellows to assess knowledge and practice in managing endometriosis-related ED complaints. Methods: A questionnaire from a prior endometriosis survey was modified for EM providers and administered anonymously via email (Qualtrics, Provo, UT) in monthly newsletters to providers at an academic and six associated community EDs. …


International Consensus-Driven Recommendations For Patient-Reported Outcome Research Objectives In Early Phase Dose-Finding Oncology Trials: Optimise-Ror, Emily Alger, Olalekan Lee Aiyegbusi, Amylou C Dueck, Anna Minchom, Madeline Pe, John D Peipert, Claire Snyder, Stefan N Symeonides, Roger Wilson, Ethan Basch, Yu Qiao, Susan E Bates, Helen Bulbeck, Lizzie Dean, Massimo Di Maio, Aaron R Hansen, Olga Kholmanskikh, Ken Kobayashi, Dónal Landers, Christophe Le Tourneau, J Jack Lee, Brigette B Y Ma, Lynley V Marshall, Sheetal Patel, Joan Petrie, Gregory R Pond, Kieran Prior, Khadija R Rantell, John F Reeve, Olga Solovyeva, Nolan A Wages, Harald A Weber, Melanie J Calvert, Christina Yap Mar 2026

International Consensus-Driven Recommendations For Patient-Reported Outcome Research Objectives In Early Phase Dose-Finding Oncology Trials: Optimise-Ror, Emily Alger, Olalekan Lee Aiyegbusi, Amylou C Dueck, Anna Minchom, Madeline Pe, John D Peipert, Claire Snyder, Stefan N Symeonides, Roger Wilson, Ethan Basch, Yu Qiao, Susan E Bates, Helen Bulbeck, Lizzie Dean, Massimo Di Maio, Aaron R Hansen, Olga Kholmanskikh, Ken Kobayashi, Dónal Landers, Christophe Le Tourneau, J Jack Lee, Brigette B Y Ma, Lynley V Marshall, Sheetal Patel, Joan Petrie, Gregory R Pond, Kieran Prior, Khadija R Rantell, John F Reeve, Olga Solovyeva, Nolan A Wages, Harald A Weber, Melanie J Calvert, Christina Yap

Faculty, Staff and Student Publications

Purpose: There is growing scientific interest in incorporating patient-reported outcomes (PROs) in early phase dose-finding oncology trials (DFOTs) to assess tolerability, inform dose selection, and guide later stage trial design. However, research indicates that PRO objectives in DFOTs are often unclear. The Incorporating Patient-Reported Outcomes in Dose-Finding Trials-Research Objectives Recommendations (OPTIMISE-ROR) project was established to support trialists to effectively incorporate PROs into DFOTs.

Methods: Using the Enhancing Quality and Transparency of Health Research (EQUATOR) Network's methodological framework, guideline development included the following: (1) a methodological review of published DFOTs incorporating PROs; (2) candidate item generation, refined through expert consultation; (3) …


Clinical Trial Success Rate In Lymphoma: Fate Of Trials And Agents From 2000 To 2019, Zhiping Luo, Meng Li, Brian C Primeaux, Rahul Shah, Ruitao Lin, Swaminathan P Iyer, Loretta J Nastoupil, Michael R Green, Jason R Westin, Christopher R Flowers, Dai Chihara Mar 2026

Clinical Trial Success Rate In Lymphoma: Fate Of Trials And Agents From 2000 To 2019, Zhiping Luo, Meng Li, Brian C Primeaux, Rahul Shah, Ruitao Lin, Swaminathan P Iyer, Loretta J Nastoupil, Michael R Green, Jason R Westin, Christopher R Flowers, Dai Chihara

Faculty, Staff and Student Publications

Although previous studies have examined the drug development and clinical trial success rates in oncology, a comprehensive analysis of development success rate in lymphoma has not been performed. Therefore, we analyzed lymphoma trials initiated between 1 January 2000 and 31 December 2019, using the Trialtrove database and ClinicalTrials.gov. We identified phase 1, 2, and 3 trials that included patients with lymphoma and analyzed the transition rate of investigational agents across phases and their US Food and Drug Administration (FDA) approval rates to assess the efficiency and success of the clinical development process. A total of 1032 phase 1 trials and …


Comparative Evaluation Of Orthodontic Measurements Using Two Intraoral Scanners Versus Conventional Plaster Models: An In Vivo Study, Pranoy Nair, Achint Juneja, Monis Raza, Prashant Shahi, Ridhi Kothari, Deepthi Raj Mar 2026

Comparative Evaluation Of Orthodontic Measurements Using Two Intraoral Scanners Versus Conventional Plaster Models: An In Vivo Study, Pranoy Nair, Achint Juneja, Monis Raza, Prashant Shahi, Ridhi Kothari, Deepthi Raj

International Arab Journal of Dentistry

Introduction: This study evaluated and compared the accuracy and reliability of two intraoral scanners, iTero Element 1 and Panda P2, with conventional plaster models for essential orthodontic measurements.

Methods: Thirty subjects were evaluated using three methods: plaster casts, iTero Element 1, and Panda P2. Inter-canine distance, inter-molar distance, overjet, overbite, and Bolton’s ratios were measured. Data was analysed using one-way ANOVA and Tukey’s post-hoc test after confirming normality (Shapiro–Wilk). Intra-operator reliability was assessed using Dahlberg’s formula and ICC.

Results: No statistically significant differences were observed among the three methods (p > 0.05). Both scanners demonstrated high repeatability and minimal measurement error, …


Evaluating Strategies For Reducing Rates Of Adult Obesity In The United States Through Childhood Education And Exercise, Ameer M. Abdelkrim Mar 2026

Evaluating Strategies For Reducing Rates Of Adult Obesity In The United States Through Childhood Education And Exercise, Ameer M. Abdelkrim

Doctoral Dissertations and Projects

Obesity is a growing national public health crisis, impacting millions of adults and children in the U.S. Untreated obesity causes or aggravates diseases across multiple body systems. The societal impacts of obesity include an avoidable strain on the national healthcare system, with obesity and its comorbid conditions raising healthcare costs. Proactive policy and practices, with strict oversight, are essential for achieving a reduction in obesity rates. One proactive strategy that may be effective is early-age intervention, including enhanced physical activity and nutrition education for U.S. children. This study evaluates adolescent-intervention strategies for reducing rates of adult obesity. The employed methods …


Investigating Nursing Instructors’ Perceptions Of Students’ Critical Thinking And Clinical Judgment After Attending A Flipped Pathophysiology Course, Ashley L. Harmon Mar 2026

Investigating Nursing Instructors’ Perceptions Of Students’ Critical Thinking And Clinical Judgment After Attending A Flipped Pathophysiology Course, Ashley L. Harmon

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand an instructor’s ability to develop critical thinking and clinical judgment for pathophysiology nursing students at a state university in the southeastern United States while using the flipped pedagogical approach. The theory guiding this study was Piaget’s constructivist theory, which aligned with the active role of learners in constructing knowledge, and supported the exploration of how flipped classrooms influenced the development of critical thinking and clinical judgment. The central research question for this study was: What are nursing instructors’ perceptions of students' development of critical thinking and clinical judgment when applying pathophysiology …


A Phenomenological Study Of Complex Post-Traumatic Stress Disorder In Combat Deployed Women Combat Veterans, Caren Valencia Chen Mar 2026

A Phenomenological Study Of Complex Post-Traumatic Stress Disorder In Combat Deployed Women Combat Veterans, Caren Valencia Chen

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to delineate factors that impact women combat veterans with Complex Post-Traumatic Stress Disorder (C-PTSD) after deployment and completion of military service. The theory guiding this was Strauss and Corbin’s grounded theory. The conceptual framework guiding the study was Crenshaw's intersectionality theory. C-PTSD is often diagnosed with service members throughout their time in the military, and after their time in the military is complete. The central research question, “What are the lived experiences of women combat veterans diagnosed with C-PTSD?” was addressed through interviews with focus groups. The sub-questions to analyze direct correlation issues …


The Schizophrenia Effect: Families Facing Schizophrenia-Spectrum Disorders, Ginger A. Christmas Mar 2026

The Schizophrenia Effect: Families Facing Schizophrenia-Spectrum Disorders, Ginger A. Christmas

Doctoral Dissertations and Projects

Schizophrenia is primarily known for its bizarre psychosis, as the brain struggles to distinguish between what is real and what is not. This qualitative study employed constructive, interpretative phenomenological analysis (IPA) to explore the idea that families with a family member diagnosed with a schizophrenia-spectrum disorder (SSD) in the United States have specific needs, which may include social and spiritual support and integration into treatment. While the needs of families facing SSD have been studied in non-Western countries, the schizophrenia effect on families in the U.S. remains less understood. A purposive sample of 11 individuals, representing 15 family members with …


The Role Of Personality In Collegiate Athletes’ Indicators Of Performance And Injury Experiences – A Mixed Methods Study, Allison Traub Mar 2026

The Role Of Personality In Collegiate Athletes’ Indicators Of Performance And Injury Experiences – A Mixed Methods Study, Allison Traub

Doctoral Dissertations and Projects

This mixed methods study explores the impact of collegiate athletes' indicators of personality traits as attributed to athletic performance, injury experiences, and sport identity. Sports often emphasize physical abilities, yet the role of personality is equally significant—though it has received comparatively little attention in psychological research. This research addresses such a gap through examining how personality traits shape athletes’ competitive behavior along with coping strategies. The traits are defined within the 16 Personalities framework using Myers-Briggs Type Indicator (MBTI) and how it influences just how athletes recover. This research will explore research questions such as how personality affects college athletes' …


Health Disparities Resulted From The Relationships Between Vulnerable Patients And Providers, Matthew Maurice Bradley Mar 2026

Health Disparities Resulted From The Relationships Between Vulnerable Patients And Providers, Matthew Maurice Bradley

Doctoral Dissertations and Projects

The study's purpose was to understand patterns of mistrust between providers and patients in vulnerable and underserved populations. The theories guiding this study were the critical theory and the critical race theory created by Max Horkheimer as it explains how people can collaborate and actively participate in rebuilding trust. The intention is to rebuild trust and reduce health disparities in the United States. The general problem is the lack of provisional resources for underserved and vulnerable communities, resulting in the population lacking trust in healthcare administration. Speicher and Francis (2022) examined how increasing physician turnover, burnout, depression, and dissatisfaction affect …


Differential Contributions Of Clpx And Clpp To Pulmonary Virulence In Classical And Hypervirulent Klebsiella Pneumoniae, Nathan M Lin, Emily C Marino, Jordan M Schlotmann, David A Rosen Mar 2026

Differential Contributions Of Clpx And Clpp To Pulmonary Virulence In Classical And Hypervirulent Klebsiella Pneumoniae, Nathan M Lin, Emily C Marino, Jordan M Schlotmann, David A Rosen

2020-Current year OA Pubs

No abstract provided.


Hematopoietic Cell Transplantation For Wiskott-Aldrich Syndrome: A Pidtc Report, Jessie L Alexander, Jeffrey J Bednarski, Et Al. Mar 2026

Hematopoietic Cell Transplantation For Wiskott-Aldrich Syndrome: A Pidtc Report, Jessie L Alexander, Jeffrey J Bednarski, Et Al.

2020-Current year OA Pubs

Wiskott-Aldrich syndrome (WAS), an X-linked disorder characterized by immunodeficiency, thrombocytopenia, autoimmunity, and malignancy, can be effectively treated with allogeneic hematopoietic cell transplantation (HCT). Older age at HCT and mismatched donors are known to affect overall survival (OS). However, the influence of specific clinical manifestations or WAS variant class on OS and factors associated with event-free survival (EFS) remain incompletely defined. We analyzed outcomes of 308 patients with WAS who underwent HCT at 37 institutions of the Primary Immune Deficiency Treatment Consortium from 1990 to 2018. With a median follow-up of 5.3 years, the 5-year OS and EFS were 87.2% and …


Ultrasound-Guided Skeletal Muscle Biopsy Technique Permits Measurement Of Structural, Functional, Cellular And Biochemical Properties, Addison Barber, Amber Willbanks, Guadalupe Meza, Jeremie L A Ferey, Gretchen A Meyer, Sudarshan Dayanidhi, W David Arnold, Richard L Lieber, Ishan Roy Mar 2026

Ultrasound-Guided Skeletal Muscle Biopsy Technique Permits Measurement Of Structural, Functional, Cellular And Biochemical Properties, Addison Barber, Amber Willbanks, Guadalupe Meza, Jeremie L A Ferey, Gretchen A Meyer, Sudarshan Dayanidhi, W David Arnold, Richard L Lieber, Ishan Roy

2020-Current year OA Pubs

Human muscle biopsies are often required to study or diagnose diseases. However, traditional approaches are challenging due to limited sample size, quality, or participant discomfort. Fine-gauge needle biopsies (≥ 14-gauge), present an alternative but may yield insufficient tissue for comprehensive analysis. Ultrasound guidance, coupled with vacuum-assisted, single needle-insertion multiple sampling addresses these challenges. In 19 healthy participants (mean age: 30.1 ± 10 years, 42% male), 2-3 samples were collected from a single needle insertion into the vastus lateralis (VL) and tibialis anterior (TA). Summed VL and TA sample masses averaged 148 ± 38 mg and 166 ± 64 mg, with …


Adaptations To An Implementation Study For Integrating Hypertension Management Into Hiv Care In Lagos, Nigeria: Application Of The Frame, Chioma Hope Nwankwo, Juliet Iwelunmor, Et Al. Mar 2026

Adaptations To An Implementation Study For Integrating Hypertension Management Into Hiv Care In Lagos, Nigeria: Application Of The Frame, Chioma Hope Nwankwo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: Implementation strategies are dynamic and multi-faceted, and may require adaptations to fit implementation contexts, especially in lower-and-middle income countries. We report the adaptations for an ongoing late-stage implementation science trial (R01HL147811) that integrates hypertension management into HIV care in Lagos, Nigeria - a country with a high dual-disease burden - through the Task Strengthening Strategy for Hypertension (TASSH) intervention and Practice Facilitation implementation strategy.

METHODS: FRAME (Framework for Reporting Adaptations and Modifications-Enhanced) modules were used to record adaptations to the intervention (i.e., TASSH) respectively, enhance participant recruitment and retention rates, and increase frequency of trainings. Data collection sources included …


Recommendations For The Diagnosis And Management Of Cln3 Disease (Batten Disease) Using The Delphi Consensus Methodology, Jonathan W Mink, Jonathan D Cooper, Et Al. Mar 2026

Recommendations For The Diagnosis And Management Of Cln3 Disease (Batten Disease) Using The Delphi Consensus Methodology, Jonathan W Mink, Jonathan D Cooper, Et Al.

2020-Current year OA Pubs

BACKGROUND: CLN3 disease, also called Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), or Batten disease, is an ultra‑rare, neurodegenerative lysosomal storage disorder generally affecting individuals during the first decade of life. There can be a delay in diagnosis or misdiagnosis due to a lack of awareness, and when the most common presenting symptom of visual loss is attributed to more common conditions affecting vision. METHODS: We used a previously published Expert Mapping Tool (EMT) to identify multidisciplinary professionals with diagnostic or clinical management expertise, as well as patient advocates with experience of CLN3 disease. A systematic literature review of published evidence using …


A Practice-Based Implementation Strategy Bundle For Integrating Behavioral Health In Primary Care: A Matrixed Multiple Case Study, Gretchen Buchanan, Kelley Mccall, Lorella Palazzo, Michelle Bagwell, Shivani Patel, Shravya Allena, Byron J Powell Mar 2026

A Practice-Based Implementation Strategy Bundle For Integrating Behavioral Health In Primary Care: A Matrixed Multiple Case Study, Gretchen Buchanan, Kelley Mccall, Lorella Palazzo, Michelle Bagwell, Shivani Patel, Shravya Allena, Byron J Powell

2020-Current year OA Pubs

BACKGROUND: Integrated behavioral health (IBH) is an evidence-based approach to addressing mental health in primary care settings. It typically involves augmenting a primary care team with a behavioral health professional (e.g., psychologist, licensed clinical social worker) who sees patients for brief, focused concerns; can function as a bridge to specialty care; and provides medical providers with support and education about patient behavioral health concerns. IBH has slowly begun to disseminate across the United States, but practices encounter significant implementation barriers. How IBH is implemented has not been systematically studied outside of trials, yet this study could provide a rich foundation …


Redesigning Online Graduate Orientation To Foster Academic Resilience And Prevent Underperformance, Stella Michael-Makri, David E. Rodriguez Mar 2026

Redesigning Online Graduate Orientation To Foster Academic Resilience And Prevent Underperformance, Stella Michael-Makri, David E. Rodriguez

Journal of Academic Underperformance

Graduate students in fully online programs often begin their academic journey without adequate preparation for the emotional, structural, and cultural challenges of graduate-level work. For students who are first-generation, racially marginalized, international, or returning to education after time away, this lack of scaffolding can lead to early disengagement, underperformance, or attrition. Orientation, often treated as a checklist of logistical tasks, represents a missed opportunity for meaningful academic intervention. This manuscript proposes a five-module conceptual model for online graduate orientation designed to proactively support online graduate students in the domains of emotional regulation and academic identity, time management and executive functioning, …


Impact Of Acute Flight Training Stress On Cardiovascular Health, Toni Butler, Noah Robbins, Sophia Vaden, Bryan Hinton Mar 2026

Impact Of Acute Flight Training Stress On Cardiovascular Health, Toni Butler, Noah Robbins, Sophia Vaden, Bryan Hinton

Student Research Symposium (SRS)

Student pilots face a unique set of stressors that are a part of their flight training. These acute stressors can have immediate and long-term impacts on their physiological and psychological well-being. Using near-infrared spectroscopy (NIRS) to measure vascular endothelial function (a marker of cardiovascular health), this investigation will help us understand how the stressors involved in acute flight training affects the cardiovascular health of student pilots. We will test the hypothesis that acute flight training stress obtained from a single bout of flight training reduces cardiovascular function as shown by a reduced post-occlusive reactive hyperemic (PORH) response. Cardiovascular health will …


Building Capacity, Changing Teaching Practices: Insights From A Professional Development Program For Educators In A Low-Income Country, Caroline Havery, Mary Kililo, Julie Dopsie, Mary Roroi, Di Brown, Ali Moloney, Lisa Townsend, Amanda Neill, Michele Rumsey, Chris Rossiter, Thelma Ali Mar 2026

Building Capacity, Changing Teaching Practices: Insights From A Professional Development Program For Educators In A Low-Income Country, Caroline Havery, Mary Kililo, Julie Dopsie, Mary Roroi, Di Brown, Ali Moloney, Lisa Townsend, Amanda Neill, Michele Rumsey, Chris Rossiter, Thelma Ali

Pacific Journal of Health

Background

Building capacity of health professional educators in low- and middle-income countries can improve population health outcomes through upskilling the health workforce. However, education programs must respond to local contexts and challenges including participants’ needs and expectations, language difficulties, and resource limitations. This paper evaluates a program for nursing and community health worker educators in Papua New Guinea.

Methods

This qualitative descriptive study was designed and implemented using a collaborative partnership approach. It comprised six focus groups with 26 educators who were program participants. Thematic analysis examined participants’ perceptions of the program and their implementation of change projects.

Results

Four …


Retrocardiac Innominate Vein: A Rare Vascular Anomaly Associated With Congenital Heart Disease, Ali Alakhfash, Osama Alrusaini, Fahad Alhabshan, Khaled Alhawri, Abdulrahman Almesned Mar 2026

Retrocardiac Innominate Vein: A Rare Vascular Anomaly Associated With Congenital Heart Disease, Ali Alakhfash, Osama Alrusaini, Fahad Alhabshan, Khaled Alhawri, Abdulrahman Almesned

Journal of the Saudi Heart Association

Atrial septal defects are common congenital heart anomalies and may coexist with rare systemic venous abnormalities. We describe a one-year-old female with a large secundum atrial septal defect and an unusual retrocardiac innominate vein. Transthoracic echocardiography suggested a persistent left superior vena cava, but the innominate vein was absent from its usual location and the coronary sinus was not dilated. Cardiac CT angiography demonstrated a retrocardiac innominate vein draining into the azygos system and subsequently to the right atrium. Surgical atrial septal defect closure was successful. Recognition of this anomaly is essential for accurate diagnosis and procedural planning.


Cv: Jennifer Reft (Physical Therapy), Jennifer Reft Mar 2026

Cv: Jennifer Reft (Physical Therapy), Jennifer Reft

Rehabilitation Sciences Department Curricula Vitae

No abstract provided.


Cv: Carly Jones (Physical Therapy), Carly Jones Mar 2026

Cv: Carly Jones (Physical Therapy), Carly Jones

Rehabilitation Sciences Department Curricula Vitae

No abstract provided.


Cv: Michael Maninang (Physical Therapy), Michael Maninang Mar 2026

Cv: Michael Maninang (Physical Therapy), Michael Maninang

Rehabilitation Sciences Department Curricula Vitae

No abstract provided.


Cv: Michelle Walaszek (Physical Therapy), Michelle Walaszek Mar 2026

Cv: Michelle Walaszek (Physical Therapy), Michelle Walaszek

Rehabilitation Sciences Department Curricula Vitae

No abstract provided.


Cv: Colleen Hanlon (Physical Therapy), Colleen Hanlon Mar 2026

Cv: Colleen Hanlon (Physical Therapy), Colleen Hanlon

Rehabilitation Sciences Department Curricula Vitae

No abstract provided.


Cv: Amy Hemkendreis (Physical Therapy), Amy Hemkendreis Mar 2026

Cv: Amy Hemkendreis (Physical Therapy), Amy Hemkendreis

Rehabilitation Sciences Department Curricula Vitae

No abstract provided.


Intouch Week Of March 9, 2026, New York Medical College Mar 2026

Penile Prosthetic Infections: What Can Be Learned From Orthopedics?, Kenneth B Mathis, Alisina Shahi Mar 2026

Penile Prosthetic Infections: What Can Be Learned From Orthopedics?, Kenneth B Mathis, Alisina Shahi

Faculty, Staff and Student Publications

No abstract provided.


Clinical And Economic Impact Of Vascular Access Teams Utilizing An Ic-Ecg-Based Tip Confirmation System For Peripherally Inserted Central Catheters., Gustavo Rc De Freitas, Sanjay A Patel, Shigeki Fujitani, Yusuke Terasaka, Angel A Sarabia Collazo, Andrew Barton, Leanne Ruegg, Amanda Griffin, Matthew O'Brien, Idal Beer Mar 2026

Clinical And Economic Impact Of Vascular Access Teams Utilizing An Ic-Ecg-Based Tip Confirmation System For Peripherally Inserted Central Catheters., Gustavo Rc De Freitas, Sanjay A Patel, Shigeki Fujitani, Yusuke Terasaka, Angel A Sarabia Collazo, Andrew Barton, Leanne Ruegg, Amanda Griffin, Matthew O'Brien, Idal Beer

Heart and Vascular Articles

INTRODUCTION: Peripherally inserted central catheters (PICCs) are commonly used in clinical practice. Historical PICC placement methods (e.g. fluoroscopy-guided placement or blind insertion with confirmatory chest X-ray) have many limitations and are associated with longer wait times, treatment delays, and potential risks to patient safety. One such way of addressing some of these issues is the use of dedicated systems that integrate ultrasound vessel selection and PICC insertion, magnetic catheter tip navigation, and intracavitary electrocardiogram-based tip confirmation (IC-ECG). The uptake of these systems has been slow in some parts of the world. This narrative review aims to assess the clinical and …


Real-World Precision Medicine Data In Metastatic Prostate Cancer - A Retrospective Cohort Study, Awais Paracha, Derek Tran, Margot Noyelle, Jonathan Kapilian, Zohair Siddiqui, Adrian Choppa, Anthony Corsi, Jacob Stone, Xin-Hua Zhu Mar 2026

Real-World Precision Medicine Data In Metastatic Prostate Cancer - A Retrospective Cohort Study, Awais Paracha, Derek Tran, Margot Noyelle, Jonathan Kapilian, Zohair Siddiqui, Adrian Choppa, Anthony Corsi, Jacob Stone, Xin-Hua Zhu

Department of Medicine Faculty Papers

Background: Prostate cancer (PC) is the most common cancer in men in the United States with a 5-year relative survival rate for people with distant metastases of 36%. We conducted a single institution, retrospective cohort study of patients with metastatic PC to investigate whether certain gene mutations can be used as predictive biomarkers.

Methods: 200 patients with metastatic hormone sensitive (mHSPC) and castration resistant (mCRPC) prostate cancer who had a FoundationOne report and were treated from June 2007 to October 2024 were included in the study. Disease progression was evaluated according to RECIST criteria, PCWG3 criteria, and PSA values. Assessed …