Medicine and Health Sciences Commons^™

Ethically Integrating Ai In Occupational Therapy Education: Enhancing Learning And Practice For The Future, Amy Sadek, Sabrina Gowette

The Open Journal of Occupational Therapy

Artificial intelligence (AI) has been around since the 1950s and is gaining traction in higher education and among health care professions. In this era of technology, it is imperative we equip both educators and students to have tech centric skills to support learning, improve efficiency, and enhance skills. Faculty and students alike need to be able to understand the ethics behind using digital information, such as that from AI tools and sources. As educators and students become more reliant on technology, and specifically AI, it is imperative not to lose the human connection in education. Educators are an integral part …

Doing Drag: Exploring The Experiences Of Drag As An Occupation For Performers In California, Alicia Montes, Anna Ranario, Lilibeth Rosales, Eileen Spahle, Nathan Gelman, Laura Greiss Hess, Karen Mccarthy

The Open Journal of Occupational Therapy

Background: Drag is a performative art where individuals explore identity, challenge societal norms, and foster community through exaggerated gendered performance. Drag in the United States is facing potential restrictions and remains underexplored in occupational science and occupational therapy literature.

Methods: This qualitative study explored the experiences of drag performers in California, applying an occupational perspective through the framework of form, function, and meaning. Five drag performers were interviewed. Reflective thematic analysis was used to interpret qualitative data.

Findings: Identity was the central theme, interconnected with form, belonging, non-belonging, meaning and motivation, and resistive occupation. Findings highlight drag …

Addressing Feeding And Eating Issues With The Pediatric Population Using A Telehealth Service Delivery Model: A Case Report, Lyndsay Fait, Raegan Furman, Devani Emery, Bryan M. Gee

The Open Journal of Occupational Therapy

Background: This case report reviews the implementation of telehealth-based occupational therapy interventions for pediatric feeding issues in a client with autism spectrum disorder (ASD) and Avoidant/Restrictive Food Intake Disorder (ARFID). It highlights the use of a synchronous telehealth service delivery model to address sensory-based feeding issues.

Method: A single-patient case report was conducted, outlining the occupational therapy process with an 11-year-old male with ASD and ARFID who receives most nutrition through G-tube feedings and presents food selectivity. Telehealth sessions were conducted via Zoom, with occupational therapy assistant students providing interventions under faculty supervision.

Results: Telehealth interventions were successfully implemented to …

Empowering Parents Through Occupational Therapy And Primary Care Partnerships: A Feasibility Study, Maureen M. Fischer, Jennifer E. Lape

The Open Journal of Occupational Therapy

Background: Partnerships between occupational therapists and primary care providers may increase parents' accessibility to needed information to support their children’s development and promote occupational engagement. The purpose of this study was to explore the feasibility and potential impact of occupational therapy-led parent education sessions in pediatric primary care.

Method: We designed a mixed methods feasibility study with two individualized parent education sessions within 2 weeks. The study took place at a pediatric primary care practice. Convenience sampling was used to recruit nine parents who met these criteria: parent/caregiver of a child 3 years of age or under, 18 years of …

Face And Content Validity Of The Corbett-Targeted Coin Test: A Survey Of Users And Experts, Carla Floyd-Slabaugh, Jeanine Beasley, Kaitlyn Anstey, Kasey Bowman, Kaitlyn Hesse, Lauren Mannes, Samantha Vansumeren, Kirk Anderson

The Open Journal of Occupational Therapy

Background: The Corbett-Targeted Coin Test (CTCT) is unique in that it measures dexterity with in-hand manipulation and proprioceptive target placement, but it lacks established face and content validity (CV).

Methods: Two mixed methods surveys were created and piloted, one for face validity (for users of the tool) and another for CV (for content experts), each using a 5-point Likert scale and open-ended comments. Quantitative data analysis included frequencies, means, and ranges. The content validity index (CVI) was calculated for CV. Qualitative data analysis used thematic analysis.

Results: The CTCT demonstrated 97.1% endorsement among users of the tool. Each item was …

The Development Of The Retire Well Program For First Responders, Boguslawa T. Syrotiak, Noralyn Davel Pickens, Cynthia Evetts

The Open Journal of Occupational Therapy

Background: First responders experience challenges during retirement transition because of exposure to stress and trauma on the job and a high level of identification with their work. Our objective was to develop a client-centered retirement transition program for first responders and their families.

Method: Using a participatory research approach, data were collected from two focus groups of health care providers and retired first responders and analyzed using a content analysis approach.

Results: Data yielded themes and subthemes leading to the development of an outline of a retirement transition program: The Retire Well program, an occupation-based program that …

The Relationship Between Burnout, Resilience, And Locus Of Control In Occupational Therapy, Tabitha Gibbs, Miguel Garcia, Karen Menard, William O'Bannon

The Open Journal of Occupational Therapy

Background: Burnout in occupational therapists is characterized by emotional exhaustion, depersonalization, and diminished accomplishment.

Method: This non-experimental correlational study, guided by Rotter’s Locus of Control Theory and the attribution theory of motivation, analyzed the relationship between resilience, locus of control, and burnout among occupational therapists using the Brief Resilience Scale, the Internal-External Locus of Control Short Scale -4, and the Copenhagen Burnout Inventory. The sample of 83 participants was obtained via questionnaires sent to a convenience sample of occupational therapists with at least 6 months of work experience in any practice setting.

Results: The results of this study …

Exploring Quality Of Life After Traumatic Brain Injury: Insights From The Peo Model, Natalie S. King, Bryan M. Gee, Mary Shotwell, Mark A. Campbell

The Open Journal of Occupational Therapy

Background: Traumatic brain injury (TBI) is a major global health concern, affecting millions of people each year. TBI often results in long-term physical, cognitive, and emotional impairments that can drastically reduce survivors' quality of life (QOL). These impairments influence daily activities, emotional well-being, social participation, and overall life satisfaction, highlighting the importance of a comprehensive approach to rehabilitation. This study seeks to provide deeper insights into the factors that influence the QOL for TBI survivors.

Methods: This research employed a phenomenological qualitative approach to understand how survivors navigate their post injury lives. Fourteen TBI survivors, aged 18 to …

Notes From Wfot: The Shared Experiences Of The Network Of Occupational Therapy Journal Editors, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

A Mild Case Of Pseudoachondroplasia In A Child: Lessons For Long-Term Primary Care, Alec J. Pupo D.O., Connor J. Stinson D.O., Autumn Dye D.O.

The Journal of Integrated Primary Care

Background: Pseudoachondroplasia (PSACH) is a rare autosomal dominant skeletal dysplasia caused by pathogenic variants in the cartilage oligomeric matrix protein (COMP) gene. It is classically characterized by early-onset growth failure, disproportionate short stature, progressive epiphyseal dysplasia, and premature degenerative joint disease. Although phenotypic variability has been reported, PSACH is often regarded as a uniformly severe condition with predictable orthopedic morbidity.

Case Presentation: We report an eleven-year-old female with genetically confirmed PSACH who demonstrates an unexpectedly mild clinical phenotype, despite a maternal history of severe disease requiring bilateral total hip replacement during adolescence. The patient exhibited mild hip dysplasia, evolving genu …

Chronic Traumatic Encephalopathy And Career Duration In Former Professional American Football Players: A Literature Review, Malik I. Watson, Chase Forbes, Bhavik Singh, Etop Udoh, Kévin Borgella, Jonathan Mosley, Erik Zarandy

The Journal of Integrated Primary Care

Background:

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease associated with repetitive head trauma and has been increasingly identified in former contact sport athletes, particularly American football players. Although the relationship between repetitive head impacts and CTE has been well documented, the role of career duration as a measurable exposure variable remains an important area of investigation. Understanding this relationship may provide clinically useful insight for primary care physicians responsible for longitudinal monitoring of individuals with extensive athletic exposure.

Methods:

This literature review examined published studies evaluating the relationship between football career duration, cumulative head impact exposure, and neuropathologic …

Integrating Oral Thc:Cbd Into Chronic Neuropathic Pain Management In Primary Care: A Two-Patient Observational Case Series, Camryn Butera, Tytianna Robinson, Samantha Temucin, Jade Mcnulty, Ryan Pinto, Maya Rakoczy, Jessica Peskin, Frederick J. Goldstein, Micky Bacchus, Sarah Kizun, Alivia Kurelowech, Alexandra Loverdi, Kruti Patel, Neha Bhardwaj, Tyler Kung, Hiren Walia, Rebecca Han, Alexa Romanella, Christie Okoye

The Journal of Integrated Primary Care

Introduction: Cannabis use among U.S. adults has increased substantially in recent years, and primary care physicians increasingly encounter patients using cannabis for chronic pain management. This case series describes two patients with chronic neuropathic pain participating in an observational study evaluating a dose-controlled oral tetrahydrocannabinol (THC): cannabidiol (CBD) formulation. Methods: Two participants completed a four-week program involving incremental oral administration of a 1:1 THC:CBD formulation. Pain intensity scores, medication use, and health-related quality of life (HRQoL) were assessed before and after the intervention. Results: Both participants reported reductions in pain intensity and decreased reliance on pre-study analgesic …

Targeting Oxidative Stress In Cadasil: Case Insights And Therapeutic Approaches, Maria Meshreky, Richard Weinberger, Giana Johnson, Andrew Abraham, Jacob Rosendale

The Journal of Integrated Primary Care

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare hereditary small-vessel disease caused by NOTCH3 mutations, leading to recurrent ischemic strokes, cognitive decline, and early-onset dementia. Oxidative stress has been implicated in the pathophysiology of small-vessel cerebrovascular disease, but therapeutic strategies targeting oxidative injury remain limited. We present a 40-year-old female with recurrent ischemic strokes involving the right and left middle cerebral arteries, persistent hypercoagulability of unknown etiology, and no identifiable inherited or acquired thrombophilia. Despite well-controlled blood pressure and standard medical management, the patient remains at high risk for cerebrovascular injury. An extensive review of …

Implementing An Integrated Primary Care Model In Outpatient Specialty Medicine: Lessons Learned And Future Directions, Kristen Perry, Rachel Allen, Katherine Dollar, Christina B. Shook, Alexandra Alvarez, April Eaker, Molly Goodrich, Jennifer Patterson

The Journal of Integrated Primary Care

The Veterans Health Administration (VHA) has a successful history of integrating behavioral health into primary care through its Primary Care Mental Health Integration (PCMHI) program, utilizing the Colocated Collaborative Care (CCC) model to improve access, early intervention, and team-based care. Recognizing this model’s utility, coupled with the high prevalence of psychological concerns among patients with chronic medical conditions—such as cancer and pain—and their associated elevated suicide risk, VHA launched the Mental and Behavioral Health Integration (MBHI) into Specialty Medicine Demonstration Projects in 2022. These projects expand CCC services into outpatient Oncology and Pain Management clinics, supported by implementation facilitation strategies …

Innovations In Developing Behavioral Health Care Managers Within Collaborative Care Programs, Jesse K. Allen-Dicker, Virginia Kelly Arlt Mutch, Derek M. Tate

The Journal of Integrated Primary Care

The collaborative care model is an effective method to treat adults with depression and other psychiatric symptom presentations within primary care settings. Research suggests that patients treated by more experienced behavioral health care managers receiving consistent supervision experience greater symptom relief. Supervision is an essential and widely accepted component of the collaborative care model, though minimal guidance has been offered on how to best implement supervision and foster behavioral health care manager development within these programs. The present paper highlights the approach developed by a collaborative care program with an emphasis placed on consistent and frequent consultation and supervision and …

Building Connections For Care: A Practical Guide For Novice Nursing Professional Development Practitioners, Debra Hunt

Student Dissertations

Building Connections for Care is a practical textbook designed to support novice Nursing Professional Development Practitioners (NPDPs) as they transition from expert bedside clinicians to educational leaders within complex healthcare systems. Grounded in the Association for Nursing Professional Development (ANPD) practice model, the book integrates ethical foundations, communication strategies, leadership frameworks, and inquiry methods to build confidence and competence in the NPDP role. Chapters trace a developmental pathway from role transition and Benner’s novice-to-expert model through ethics and just culture, incivility and workplace culture, and communication skills including feedback, SMART goals, SBAR, and professional digital conduct. Subsequent chapters expand NPDP …

Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach To Enhance Therapeutic Potential In Nonalcoholic Steatohepatitis, Tharani Senavirathna, Shafaei, Ricky Lareu, Lois Balmer

Research outputs 2022 to 2026

This mouse study investigates the efficacy of ellagic acid (EA), a potent antioxidant in fruits and nuts, and inulin, a prebiotic known for gut microbiota benefits, in nonalcoholic steatohepatitis (NASH). A Western-style diet (WD) was used to induce NASH in C57BL/6J male mice for 16 weeks. Mice then received EA (100 mg/kg/day, oral gavage, 5 days/week) and/or 5% inulin (w/w in diet) for 12 weeks while continuing WD. Inulin increased energy intake and trended toward higher body weight and fasting glucose. EA reduced liver weights and restored the liver-to-body weight ratio. EA and inulin combined significantly reduced steatosis and hepatocyte …

Horseshoe Kidneys In Transplantation: Underutilization Despite Comparable Quality And Favorable Outcomes: Unos Registry Analysis (2007-2023), Abigail W. Cheng, Samrawi Misiker, Roberto Sagaribay, Kavita Batra

School of Medicine Research Poster Showcase

Introduction: Horseshoe kidneys (HSKs) are the most common renal fusion anomaly, occurring in approximately 1 in 500 individuals and often discovered incidentally. Historically excluded from transplantation due to complex anatomy, advances in surgical techniques have made HSK transplantation increasingly feasible. Although successful procurement and transplantation have been described in case reports, national-level data comparing donor characteristics and organ utilization between HSK and non-HSK donors remain limited. This study characterizes donor demographics, clinical profiles, and organ utilization of HSK donors using the United Network for Organ Sharing (UNOS) database.

Methods: A retrospective analysis of the UNOS kidney transplant registry was performed, …

Prmt5 Inhibition Impairs Fanconi Anemia Pathway-Mediated Homologous Recombination And Enhances The Antitumor Efficacy Of Temozolomide In Glioblastoma, Shumpei Onishi, Sridharan Jayamohan, Ashis Chowdhury, Sarah Rivas, Yoshihiro Otani, Celine Ertekin, Jean-Paul Bryant, Sara A Murphy, Kimberly A Rivera-Caraballo, Stuart Walbridge, Bayu Sisay, Dragan Maric, Abdel Elkahloun, Kory Johnson, Desmond A Brown, John D Heiss, Ashish H Shah, Tae Jin Lee, Sangamesh G Kumbar, Ji Young Yoo, Andrew J Brenner, Balveen Kaur, Gangadhara R Sareddy, Yeshavanth Kumar Banasavadi-Siddegowda

Faculty, Staff and Student Publications

Despite multimodal therapy of surgical resection, radiation, and chemotherapy, glioblastoma patients show a dismal prognosis. Protein Arginine Methyltransferase 5 (PRMT5) is overexpressed in glioblastoma, and its inhibition imparts an anti-tumor effect. Tumor cells invariably develop resistance to Temozolomide (TMZ), the standard chemotherapeutic agent for glioblastoma. However, the mechanistic role of PRMT5 in treatment-resistant glioblastoma is unknown. Patient-derived glioma stem-like cells (GSCs), treated with PRMT5 inhibitor (LLY-283) or transfected with PRMT5-target-specific siRNA, were treated with TMZ and subjected to in vitro functional and mechanistic studies. The intracranial mouse xenograft model was used to test the in vivo antitumor efficacy of combination …

Process Evaluation Of The Cheers Automated A1c Follow-Up Reminder System In Primary Care, Heather E. Lewis

Doctoral Dissertations & Projects

Background: Missed diabetes follow-up contributes to suboptimal glycemic control in primary care. Health record embedded reminder systems may improve continuity of care, but process evaluation is needed to understand real-world implementation (Bugge, 2024; Rathod et al., 2024).

Objective: To evaluate fidelity, workflow processes, and reach of the Cheers automated A1c reminder program among adults with type 2 diabetes in primary care.

Methods: This retrospective process evaluation used EHR data guided by the CDC Program Evaluation Framework (CDC, 2024). Measures included reminder delivery, follow-up completion, fidelity, and contextual factors.

Results: Of 72 eligible patients, 26 met success criteria (36.1%); 92.0% completed …

Acute Musculoskeletal Injuries In Kids—Assessment, Imaging & Return-To-Play, Mike Smith, Kevin Latz Md

Pediatrics in Practice: A CME Podcast

How should pediatricians triage an acute sports injury—what to check first, what imaging to order, and when to escalate urgently? In this Pediatrics in Practice CME episode, Kevin Latz, MD, MBA shares a practical framework for assessment, red flags, return-to-play counseling, and prevention strategies for active kids.

Click here to stream the podcast episode.

Convergent Rna Pathophysiology In Amyotrophic Lateral Sclerosis, Hunter Lee Patterson

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores the connection between amyotrophic lateral sclerosis pathogenesis and RNA biology via two mechanisms: microRNA regulation of gene expression in the spinal cord and modulation of TDP-43 pathology through synthetic oligonucleotides. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective loss of motor neurons in the brain and spinal cord that leads to progressive weakness. However, despite this shared clinical pattern the known causes of ALS are extremely varied. Only about 10% of ALS cases are familial while the other 90% occur sporadically. Even among that small fraction of familial cases, researchers have identified dozens …

Growing Healthy Habits: Impacts Of A Youth Community Garden For Children In Rural Mississippi, Olivia G. Degravelle

Honors Theses

This study examines the implementation and outcomes of a Youth Garden Program conducted in Pontotoc, Mississippi. Funded by the Allstate Community Service Project Grant, the Youth Garden was constructed within the previously established Pontotoc Community Garden. The initiative comprised four weekly workshops designed for participants ranging from preschool to adolescence. Each session incorporated hands-on fruit and vegetable (FV) planting or harvesting, an educational lesson, and a complementary craft activity. Children’s FV consumption patterns, nutritional knowledge, and attitudes toward FV were assessed through pre- and post-program surveys. In addition, the photo-elicitation interview method invited participants to take digital photographs of garden …

The Influence Of The Timing Of Definitive Restoration Placement After Root Canal Completion: A 22-Year Retrospective Study, Shikha Gupta

Master's Theses (2009 -)

Objective: To evaluate how the time interval between root canal obturation and the placement of a definitive restoration impacts the incidence of tooth failure, defined as non-surgical retreatment, apical surgery, or extraction. Methods: This 22-year-retrospective cohort study utilized electronic health records from the Marquette University School of Dentistry (MUSoD) axiUm database, analyzing 11,002 teeth treated between 2004 and 2026. Inclusion criteria required patients to be at least 18 years of age, categorized as established patients of record, with all non-surgical root canal treatments (NSRCT) meeting the 2020 AAE quality standards. The interval between obturation and restoration was categorized into seven …

Anesthetic Management In Patients With Impella Devices: A Retrospective Review And Clinical Guide, Harrison Yang, Divakara Gouda, Kent B. Berg, Katherine Green, Suvan Sundaresh, Basavana Goudra

Department of Anesthesiology Faculty Papers

Background: The Impella family of percutaneous a left ventricular assist devices are increasingly used for hemodynamic support in patients with cardiogenic shock or advanced heart failure. However, guidance on anesthetic management for patients with Impella support undergoing noncardiac procedures remains sparse. This study reviews perioperative practices and outcomes to inform clinical management.

Methods: Following institutional review board approval, a retrospective analysis was performed of adult patients receiving an Impella device (2.5, CP, 5.0, or 5.5) at Thomas Jefferson University Hospital, Philadelphia, USA, between December 2017 and October 2024. Patients, who subsequently underwent procedures involving anesthesia care were included. Demographics, procedure …

A Multilevel Analysis Of Prescriber-Reported Buprenorphine Induction Challenges In Fentanyl-Endemic Settings, Alyssa Vawn Long

Walden Dissertations and Doctoral Studies

The emergence of illicitly manufactured fentanyl has increased clinical uncertainty during buprenorphine induction in medication-assisted treatment for opioid use disorder. The purpose of this quantitative, retrospective cohort study, guided by the Transtheoretical Model (TTM), was to examine whether prescriber-level buprenorphine induction practices and experiences with precipitated withdrawal were associated with reported buprenorphine induction challenges, and whether county-level fentanyl prevalence contributed to these challenges after accounting for geographic clustering. Secondary, de-identified archival data were obtained from the National Institute on Drug Abuse Clinical Trials Network study CTN-0134 and included 64 prescribers practicing in fentanyl-endemic settings. Buprenorphine induction challenges were operationalized as …

Promoting Mental Wellness And A Calm Learning Environment In A 2nd Grade Classroom, Grace Tone

Capstone Projects

Promoting mental wellness and implementing cognitive behavioral strategies brings awareness to staff and students and helps to promote a calm learning environment. School-based occupational therapists support students to participate in school occupations that they may be struggling with and provide them with cognitive behavioral strategies to regulate their emotions. The ACOTE concentration area for this capstone included education to staff members on the impact of mental wellness on student participation in school occupations and education on the Calm Moment Cards program from Every Moment Counts. The second ACOTE concentration area for this capstone was program development for sustainability of the …

G1p3 Dysregulates Interferon-Stimulated Gene Expression In Er (+) Breast Cancer Cells, Karina Santana

Honors Theses

Even with advances in diagnosis and treatment, breast cancer remains the second leading cause of cancer-related death in women, with nearly 90% of fatalities linked to drug resistance driven by metastasis and recurrence. G1P3, an anti-apoptotic mitochondrial protein, is upregulated in breast cancer and has been associated with increased metastatic potential and poor prognosis. Recent findings show that G1P3 enhances interactions between Rab5-containing endosomes (RCEs) and mitochondria, and emerging evidence suggests that mitochondria play a critical role in initiating interferon (IFN) responses. Based on this, we hypothesized that G1P3-mediated interactions between RCEs and mitochondria promote interferon-stimulated gene (ISG) expression in …

To Seize Or Not To Seize? That Is The (Epigenetic) Question

Faculty, Staff and Students Publications

No abstract provided.

Inflammation- And Resolution-Programmed Myeloid Circuits Govern Therapeutic Resistance In Epithelial And Mesenchymal Triple-Negative Breast Cancer, Yichao Shen, Ling Wu, Zhan Xu, Yunfeng Ding, Xiaoxin Hao, Weijie Zhang, Hilda L Chan, Jun Liu, Bo Wei, Yang Gao, Luis Becerra-Dominguez, Yi-Hsuan Wu, Siyue Wang, Tobie D Lee, Xuan Li, Xiang Chen, David G Edwards, Xiang H-F Zhang

Faculty, Staff and Students Publications

Single-cell analysis of human triple-negative breast cancer revealed heterogeneous macrophage populations with opposing phenotypes - proinflammatory and proresolution of inflammation. Paradoxically, both subsets accumulated in therapy-refractory residual tumors but showed inverse correlations across patients, suggesting mutually exclusive resistance mechanisms. Inflammatory macrophages localized preferentially to epithelial-like tumors, whereas proresolution macrophages were enriched in mesenchymal-like tumors. Mouse models faithfully recapitulated these patterns. After chemoimmunotherapy, mesenchymal-like tumors expanded proresolution macrophages through phagocytosis/efferocytosis, ω-3 fatty acid uptake, and resolvin production. Macrophage-secreted C1q emerged as a principal antagonist of T cell function by targeting mitochondria and inducing metabolic dysfunction. By contrast, epithelial-like tumors accumulated inflammatory …