Medicine and Health Sciences Commons^™

Treatment Of Deep Bite Using Clear Aligner Therapy, Robert Zhou, Mahban Zarei

Excellence Day

Background: Deep bite is a type of malocclusion that can lead to problems with bite, mastication, speech, and has the potential to damage teeth and gums. While conventional orthodontic treatments have been shown to be effective in addressing this condition, the use of clear aligners for this purpose has not been fully explored in the current scientific literature. Objective: The objective of this retrospective longitudinal study is to evaluate the treatment effects of clear aligners in patients with deep bite malocclusion by examining the dental and skeletal changes between the initial and final treatment time points. Our null hypothesis states …

Adhesion And Minimally Invasive Dentistry, Sana Mohd, Javid Shaikh, Vidhi Bhuva, Vishwash Patel

Excellence Day

G. V. Black, the father of modern dentistry believed in extension for prevention. Today we have come a long way. We practice minimally invasive dentistry which is possible because of adhesion. We have eight generations of bonding systems. 4th generation is the gold standard, while 6th ,7th and 8th are used extensively. Direct restorations which involve minimally invasive procedure alternatives for carious lesion management, include the use of sealants, infiltration, atraumatic restorative treatment (ART), and selective carious tissue removal (e.g., indirect pulp capping, stepwise removal, or selective removal to soft dentine). Due to adhesion and the invention of higher quality …

A Review Of External Cervical Resorption, Sarah Makkiyah, Max Kazantcev

Excellence Day

Invasive cervical resorption (ECR) is a complex form of external resorption. It is distinguished by its localization, its invasive nature, and the formation of a mineralized replacement tissue resembling cellular cementum. During initiation of ECR, the portal of entry is the cementum below the gingival epithelium, and resorption starts with localized destruction and removal of PDL. Response to PDL injury includes formation of a blood clot and inflammation, followed by granulation tissue, recruitment of macrophages, and multinucleated-cell differentiation.

Three-Dimensional Analysis Of Nasoalveolar Molding Treatment (Nam) Effects In Unilateral Cleft Lip, Alveolus, And Palate Patients, Sophie Dipietro, Meghan Hansen, Yoon Weon Suh

Excellence Day

Background: NAM therapy is a non-surgical method that aims to improve both the aesthetic and functional outcomes of cleft lip and palate treatment in newborns. It applies controlled pressure to the cleft region, allowing for the reshaping of the area. However, further research is necessary to gain a deeper understanding of the underlying factors that influence cleft palate closure patterns and identify the regions that play the most significant role in approximating clefts. Objective: The aim of this study was to assess the impact of pre-surgical nasoalveolar molding (NAM) on infants with unilateral cleft lip and palate, with a hypothesis …

3d Printing In Restorative Dentistry, Sucharu Ghosh, Mahban Zarei, Parul Kumar, Priya Prasannakumar, Patrick Pansoy

Excellence Day

The term 3 D printing is generally used to describe a manufacturing approach that builds objects one layer at a time, adding multiple layers to form an object The presentation aims to provide a comprehensive understanding of the use of 3 D printing technology in restorative dentistry and its potential impact on the field

Human Dental Pulp Stem Cell Culture Model For Studies On Etiopathogenesis Of Nonsyndromic Cleft Lip With Or Without Cleft Palate Anomaly, Tyler Starley, Jonathan Starley, Harrison Truman

Excellence Day

Nonsyndromic cleft lip with or without cleft palate (NSCLP) occurs approximately in 1 of 700 live births. It has a serious impact on a patient during the whole life. It was shown that it can be prevented by supplementation of folic acid. However, much more needs to be known about etiopathogenetic factors and molecular mechanisms leading to NSCLP in order to personalize its prevention. Basic science information on etiology and pathogenesis of NSCLP was obtained from animal experiments. Clinical studies and trials showed efficacy of prevention by folic acid supplementation. A cell culture model is needed for studies on cellular …

Conventional Vs Digital Impressions, Vinitha Gopal-Murthy, Mirna Merhi-Boghossian, Geet Shukla

Excellence Day

Summary: A dental impression is a negative replica of the hard and soft tissues of the oral cavity. Conventional impressions help make dental casts which are used for diagnostic and therapeutic purposes. Digital impression involves a 3D intraoral scanning, which is processed by the impression involves a 3D intraoral scanning, which is processed by the computer to generate a virtual replica of the tissues in the mouth. In siloxanes, poly sulfides, addition and condensation silicones are used. Digital impressions can be a closed system like CEREC, that relies on one manufacturer and technology for CAD/CAM procedures or open systems like …

Comparison Of Various Post-Systems In Endodontically Treated Teeth, Viraj Ketkar, Hemal Pandya, Fariba Yaghoobi

Excellence Day

Summary: This study aims to compare various post-systems used in endodontically treated teeth. A comprehensive literature review was conducted to identify studies that compared different post systems in endodontically treated teeth. The inclusion criteria included studies comparing two or more post-systems regarding clinical and/or radiographic outcomes. The studies included in the review evaluated different types of post systems, including prefabricated metal posts, custom-made metal posts, fibre-reinforced posts, and zirconia posts. The outcomes evaluated included retention rates, fracture rates, and marginal adaptation. Cast posts offer customization benefits but need multiple appointments, while prefabricated posts are widely used for their various material, …

The Effects Of Cigarette Smoke On Sars-Cov-2 Infection In The Oral Cavity – A Preliminary Literature Review, Youyoung Min

Excellence Day

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been suggested to replicate and be found in the oral cavity. The objective of this preliminary literature review is to determine the effects of cigarette smoke on the risk of SARS-CoV-2 infection in the oral cavity, and the risk for the overall health. SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), uses the ACE2 receptor and protease TMPRSS2 for entry into host cells. The cigarette smoke condensates upregulates these receptors in human gingival epithelial cells. Because smoking can alter expression of COVID-19 viral entry genes, smokers are more susceptible to SARS-CoV-2 infection. Several …

The Joint Archives Quarterly, Volume 33.01: Spring 2023, Emma Gail Compton, Sarah Lundy

The Joint Archives Quarterly

No abstract provided.

Sexual Activity And Intimacy Within Occupational Therapy Practice, Anya Levanduski, Susan Macdermott

Spring 2023 Virtual OTD Capstone Symposium

Sexual activity is often the forgotten ADL, that is underdressed in practice, and not spoken about in academia. This presentation aims to explore the role of occupational therapy addressing sexuality and intimacy following the onset of long term physical or neurological disabilities. This project outlines the role of OT in emerging practice in advocating for the development of a referral pathway specific for sexual activity and intimacy, and OT within an emerging setting.

A New Method For Investigating Bioequivalence Of Inhaled Formulations: A Pilot Study On Salbutamol, Homa Razaei, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Hamed Hamishehkar, Mohammad Reza Afshar Mogaddam, Elaheh Rahimpour, Reza Mehvar, Abolghasem Jouyban

Pharmacy Faculty Articles and Research

Purpose: An efficient, cost-effective and non-invasive test is required to overcome the challenges faced in the process of bioequivalence (BE) studies of various orally inhaled drug formulations. Two different types of pressurized meter dose inhalers (MDI-1 and MDI-2) were used in this study to test the practical applicability of a previously proposed hypothesis on the BE of inhaled salbutamol formulations.

Methods: Salbutamol concentration profiles of the exhaled breath condensate (EBC) samples collected from volunteers receiving two inhaled formulations were compared employing BE criteria. In addition, the aerodynamic particle size distribution of the inhalers was determined by employing next generation impactor. …

Redefining Anger For Sexual And Gender Minorities Using Art As A Visual Voice, Kirsten Ranheim

Expressive Therapies Capstone Theses

Art therapy is an increasingly popular approach for addressing trauma and anger in clinical settings. This literature review explores the connections between art therapy, trauma, gender, and anger, drawing on a range of studies and theoretical perspectives. Background is provided on the history of anger within the context of societal institutions, interpersonal power dynamics, psychiatric nosology, and social justice movements. The review concludes that art therapy is ideally suited as a trauma-informed approach to addressing anger in the therapeutic setting. This is due to the unique opportunities that art making provides for helping individuals express and process their emotions nonverbally, …

Why Understanding Food Choice Is Crucial To Transform Food Systems For Human And Planetary Health, Krystal K. Rampalli, Christine E. Blake Ph.D., Rd, Edward A. Frongillo Ph.D., Joseph Montoya

Faculty Publications

What, how and why people eat has long been understood to be important for human health, but until recently, has not been recognised as an essential facet of climate change and its effects on planetary health. The global climate change and diet-related health crises occurring are connected to food systems, food environments and consumer food choices. Calls to transform food systems for human and planetary health highlight the importance of understanding individual food choice. Understanding what, how and why people eat the way they do is crucial to successful food systems transformations that achieve both human and planetary health goals. …

Prevalence, Trends, And Predictors Of Domestic Violence Among Nigerian Women; An Analysis Using 2008, 2013 And 2018 Waves Of The Nigeria Demographic Health Survey (Ndhs), Nkemdilim Chukwueme

NYMC Student Theses and Dissertations

Domestic violence (abbreviated DV for this study) among women in African settings is often considered a ‘family matter’ and requires limited external interference. This study aims to identify the national and regional prevalence, trend in prevalence rates, influencing factors in predicting domestic violence among Nigerian women, victims’ response in seeking help, and potential victim-centered digital solutions to addressing domestic violence. In Nigeria, little has been done to assess; a nationally representative prevalence of DV among Nigerian women in the last decade to see if there are changing trends in prevalence; extensively investigate the influence of socio-demographic factors in predicting DV …

Photodynamic Therapy Agents: The Power Of Mjöllnir To Eradicate Cancer, Sidney M. Hopper

Honors College Theses

After its discovery back in the 1900s, photosensitizers became a critical study for potential treatments and cures for medical issues, including cancer. It was discovered that porphyrins appeared to target and accumulate in proliferating cells, and to reach the cells, a certain wavelength of light with maximum absorbance associated with the porphyrin was necessary to achieve cell death. Photodynamic therapy involves making use of porphyrins or metalloporphyrins as activators when exposed to such light. When activated, these compounds generate reactive oxygen species (ROS), such as HO- or O2-, which can react with nucleic acids found in DNA and RNA. In …

A Multimodal Smartphone Application Intervention To Achieve Target Weight Goals In Overweight Adult Diabetics, Michael Thomas Schwuchow

Evidence-Based Practice Project Reports

Obesity is the leading risk factor for developing type 2 diabetes mellitus (American Diabetes Association, 2022). Diabetes mellitus (DM) and obesity put individuals at higher risk for developing heart disease, stroke, and hypertension, therefore, it is essential to properly manage both conditions. The purpose of this project is to determine if the implementation of an evidence-based weight loss intervention, MyFitnessPal© will result in reduction in body mass index (BMI) and lower hemoglobin A1c (HbA1c) levels in overweight adults with DM. A comprehensive literature search of six databases, hand searching, and citation chasing yielded 13 pieces of moderate to high quality …

Transcendence: Exploring The Connections Between Transgender/Gender Non-Conforming Identities And Experiences Of Nature Through Art, Mc Jackson

Undergraduate Theses

“Transcendence: Exploring the connections between transgender/gender non-conforming identities and experiences of nature through art” is the written portion of a creative thesis revolving around an immersive art installation and short film. Transcendence, the installation, was created to promote connection by exploring the overlap between transgender and gender non-conforming (GNC) experiences and experiences of nature. Part of this installation is a short film of interviews conducted with transgender and GNC individuals about nature, their gender experiences, and the transcendent nature of the two. The written thesis analyzes existing literature on nature as a restorative, therapeutic, spiritual setting, offers insight into …

Associations Between Cannabis Use, Polygenic Liability For Schizophrenia, And Cannabis-Related Experiences In A Sample Of Cannabis Users, Emma C Johnson, Sarah M C Colbert, Paul W Jeffries, Rebecca Tillman, Nicole R Karcher, Elliot C Nelson, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

BACKGROUND AND HYPOTHESIS: Risk for cannabis use and schizophrenia is influenced in part by genetic factors, and there is evidence that genetic risk for schizophrenia is associated with subclinical psychotic-like experiences (PLEs). Few studies to date have examined whether genetic risk for schizophrenia is associated with cannabis-related PLEs.

STUDY DESIGN: We tested whether measures of cannabis involvement and polygenic risk scores (PRS) for schizophrenia were associated with self-reported cannabis-related experiences in a sample ascertained for alcohol use disorders (AUDs), the Collaborative Study on the Genetics of Alcoholism (COGA). We analyzed 4832 subjects (3128 of European ancestry and 1704 of African …

Secondary Data Analysis: Predictors Of Employment Among Young Adults With Cerebral Palsy, Eduardo Santos Del Rosario

Theses & Dissertations

Young adults with cerebral palsy have lower employment rates as compared to young adults in general, as they may be confronted with complex interactions between cognitive delays, physical impairments, activity limitations, participation challenges, and personal and/or societal barriers as they progress to adulthood. These challenges are clear, the solutions, less so. Understanding the predicting factors of employment is vital to future generations of this population. The purpose of this study is to identify predictor variables and examine the relationship of those variables to employment. It has explored existing Rehabilitation Services Administration (RSA-911) data through the lens of the International Classification …

In Vitro Characterization Of A Novel Murine Model Of Cancerous Progression, Steven D. Scahill, Kelly Jean Sherman, Jessie J. Guidry, Whitney Walkowski, Theresa Nguyen, Durwood B. Ray, David H. Jones, Harry J. Gould, Dennis Paul

School of Graduate Studies Faculty Publications

To evaluate a potentially valuable tool to study cancer progression and metastasis, we characterized a novel murine model composed of a parental oncogene-transformed embryonic fibroblast line and five cell lines isolated from progressively advanced tumors. Lines derived from distant metastases displayed significantly greater rates of motility, invasiveness, and extracellular acidification than lines derived from a primary tumor or local metastases. A comprehensive proteomic analysis of these cells showed numerous oncogenes to be upregulated and tumor suppressors to be downregulated in the advanced lines, and provided novel targets for future examination. The first cell line capable of extravasation displayed particularly high …

Suprathreshold Auditory Processes In Listeners With Normal Audiograms But Extended High-Frequency Hearing Loss, Srikanta K. Mishra, Qian-Jie Fu, John J. Galvin Iii, Andrea Galindo

Communication Sciences & Disorders Faculty Publications

Hearing loss in the extended high-frequency (EHF) range (>8 kHz) is widespread among young normal-hearing adults and could have perceptual consequences such as difficulty understanding speech in noise. However, it is unclear how EHF hearing loss might affect basic psychoacoustic processes. The hypothesis that EHF hearing loss is associated with poorer auditory resolution in the standard frequencies was tested. Temporal resolution was characterized by amplitude modulation detection thresholds (AMDTs), and spectral resolution was characterized by frequency change detection thresholds (FCDTs). AMDTs and FCDTs were measured in adults with or without EHF loss but with normal clinical audiograms. AMDTs were …

"I'M Clean And Sober, But Not Necessarily Free": Perceptions Of Buprenorphine Among Patients In Long-Term Treatment, Jessica J. Wyse, Travis I. Lovejoy, Adam J. Gordon, Katherine Mackey, Anders Herreid-O'Neill, Benjamin J. Morasco

OHSU-PSU School of Public Health Faculty Publications and Presentations

Patients receiving buprenorphine for the treatment of opioid use disorder (OUD) experience a roughly 50% reduction in mortality risk relative to those not receiving medication. Longer periods of treatment are also associated with improved clinical outcomes. Despite this, patients often express desires to discontinue treatment and some view taper as treatment success. Little is known about the beliefs and medication perspectives of patients engaged in long-term buprenorphine treatment that may underlie motivations to discontinue.

Bibliometric Analysis Of Academic Journal Recommendations And Requirements For Surgical And Anesthesiologic Adverse Events Reporting, Tamir N. Sholklapper, Jorge Ballon, Aref S. Sayegh, Anibal La Riva, Laura C. Perez, Sherry Huang, Michael Eppler, Gregg Nelson, Giovanni Marchegiani, Robert Hinchliffe, Luca Gordini, Marc Furrer, Michael J. Brenner, Salome Dell-Kuster, Chandra Shekhar Biyani, Nader Francis, Haytham M.A. Kaafarani, Matthias Siepe, Des Winter, Julie A. Sosa, Francesco Bandello, Robert Siemens, Jochen Walz, Alberto Briganti, Christian Gratzke, Andre L. Abreu, Mihir M. Desai, Rene Sotelo, Riaz Agha, Keith D. Lillemoe, Steven Wexner, Gary S. Collins, Inderbir Gill, Giovanni E. Cacciamani

Einstein Health Papers

BACKGROUND: Standards for reporting surgical adverse events (AEs) vary widely within the scientific literature. Failure to adequately capture AEs hinders efforts to measure the safety of healthcare delivery and improve the quality of care. The aim of the present study is to assess the prevalence and typology of perioperative AE reporting guidelines among surgery and anesthesiology journals.

MATERIALS AND METHODS: In November 2021, three independent reviewers queried journal lists from the SCImago Journal & Country Rank (SJR) portal (www.scimagojr.com), a bibliometric indicator database for surgery and anesthesiology academic journals. Journal characteristics were summarized using SCImago, a bibliometric indicator database extracted …

Colonizing And Virulence Factors In Enterotoxigenic Escherichia Coli From Peru, Fulton P Rivera, Anicia Medina, Maribel Riveros, Theresa J Ochoa, Maria J Pons, Joaquim Ruiz

Faculty, Staff and Student Publications

Enterotoxigenic Escherichia coli (ETEC) ranks among the most relevant diarrheagenic pathogens. Efforts to design vaccines to fight ETEC have been focused on colonizing factors (CFs) and atypical virulence factors (AVF). An effective vaccine must account for differences in the regional prevalence of these CFs and AVFs to be truly effective in a given area. In the present study, the presence of 16 CFs and 9 AVFs, as well as the heat-stable (ST) variants (STh or STp), was established by polymerase chain reaction in 205 Peruvian ETEC isolates (120 from diarrhea cases and 85 from healthy controls). Ninety-nine (48.3%) isolates were …

Targeting Social Connection In The Context Of Trauma: Functional Outcomes And Mechanisms Of Change, Andrew J. Smith, David Pincus, Bernard P. Ricca

Psychology Faculty Articles and Research

The current study presents and preliminarily tests a brief, theory driven intervention designed to target social connectivity as a transdiagnostic mechanism of health. We tested four hypotheses to examine whether and how explicitly targeting social behavior engagement (activating values-led behaviors towards specific network members) may improve other downstream aspects of social connectivity (i.e., social cognitions measured as loneliness, interpersonal closeness, perceived social support) and functioning (quality of life [QOL] and posttraumatic stress symptoms [PTS]). Methods. Participants included 15 patients (10 veterans, 5 firefighters) who completed the six-session intervention. Demographics: age (M = 46, SD = 17), 87% male, race (80% …

A Realistic Path Towards A More Affordable Healthcare System For The United States, James Loome

Honors Theses

This study was performed in order to try to discover ways in which the American healthcare system can improve and become more affordable for its citizens. The main focus was to see how implementing a universal healthcare system could benefit the United States. I analyzed aspects of many different universal healthcare system structures and chose aspects that I think should or should not be included in a revised version of the US healthcare system. There was a strong focus on the aspects of Japan and Costa Rica’s healthcare systems. I also pointed out weaknesses in the US healthcare system that …

Microparticle-Delivered Cxcl9 Prolongs Braf Inhibitor Efficacy In Melanoma, Gabriele Romano, Francesca Paradiso, Peng Li, Pooja Shukla, Lindsay N Barger, Olivia El Naggar, John P Miller, Roger J Liang, Timothy L Helms, Alexander J Lazar, Jennifer A Wargo, Francesca Taraballi, James C Costello, Lawrence N Kwong

Faculty, Staff and Student Publications

Patients with BRAF-mutant melanoma show substantial responses to combined BRAF and MEK inhibition, but most relapse within 2 years. A major reservoir for drug resistance is minimal residual disease (MRD), comprised of drug-tolerant tumor cells laying in a dormant state. Towards exploiting potential therapeutic vulnerabilities of MRD, we established a genetically engineered mouse model of BrafV600E-driven melanoma MRD wherein genetic BrafV600E extinction leads to strong but incomplete tumor regression. Transcriptional time-course analysis after BrafV600E extinction revealed that after an initial surge of immune activation, tumors later became immunologically "cold" after MRD establishment. Computational analysis identified candidate T-cell recruiting chemokines as …

Impact Of Clonal Plasma Cells In Autografts On Outcomes In High-Risk Multiple Myeloma Patients, Oren Pasvolsky, Denái R Milton, Mikael Rauf, Sassine Ghanem, Adeel Masood, Ali H Mohamedi, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Guilin Tang, Hans C Lee, Krina K Patel, Partow Kebriaei, Sheeba K Thomas, Donna M Weber, Robert Z Orlowski, Katy Rezvani, Richard Champlin, Elizabeth J Shpall, Pei Lin, Muzaffar H Qazilbash

Faculty, Staff and Student Publications

Most patients with multiple myeloma (MM) undergoing autologous hematopoietic stem cell transplantation (autoHCT) eventually relapse, perhaps due to the presence of clonal plasma cells (CPC) in the autograft. We conducted a retrospective analysis to evaluate the impact of CPC in the autograft on the outcomes of high-risk chromosomal abnormalities (HRMM) patients undergoing autoHCT between 2008 and 2018. Patients were divided into CPC+ or CPC- in the autograft by next-generation flow cytometry (NGF). There were 75 CPC + autografts (18%) and 341 CPC- (82%). The CPC + group was less likely to achieve MRD-negative complete remission post-transplant (11% vs. 42%; p < 0.001). Median progression free survival (PFS) and overall survival (OS) were (12.8 vs. 32.1 months) and (36.4 vs. 81.2 months) in the CPC + and CPC- groups, respectively (both p < 0.001). Also in the subset of patients with MRD-negative ≥VGPR prior to autoHCT, those with CPC + autografts had inferior PFS (HR 4.21, p = 0.006) and OS (HR 7.04, p = 0.002) compared to CPC-. In multivariable analysis, the degree of CPC positivity in the autograft was independently predictive of worse PFS (HR 1.50, p = 0.001) and OS (HR 1.37, p = 0.001). In conclusion, both the presence and degree of CPC in the autograft were highly predictive of inferior PFS and OS.

Clinical Outcomes Of Immunotherapy Continued Beyond Radiographic Disease Progression In Older Adult Patients With Advanced Non-Small Cell Lung Cancer, Eric K Singhi, Frank Mott, Michelle Worst, Cheuk Hong Leung, J Jack Lee, Brett Carter, Carolyn J Presley, John V Heymach, Mehmet Altan

Faculty, Staff and Student Publications

Immunotherapy is an effective and generally well-tolerated treatment strategy for older adult patients (aged ≥70 years) with advanced non-small cell lung cancer (NSCLC). Unfortunately, most patients who receive immunotherapy eventually exhibit disease progression during treatment. The present study reports on a subset of older adult patients with advanced NSCLC who could effectively continue immunotherapy beyond radiographic disease progression due to perceived clinical benefit. Local consolidative radiotherapy may be used in select older adult patients to prolong the duration of immunotherapy they receive, with a particular consideration of their preexisting co-morbidities, performance status and tolerance of potential toxicities associated with combined …