Medicine and Health Sciences Commons^™

Intravenous Thrombolytic Therapies In The Management Of Unknown Onset And Wakeup Strokes: A Scoping Review, Saima Nazish

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT Background: The efficacy and safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the management of unknown time onset stroke (UTOS) and wake-up stroke (WUS) are in a debate. Objective:The objective of this review is to discuss the UTOS and its management with intravenous thrombolytic therapies. Data Sources: Databases searched included PubMed and Cochrane electronic databases and manual search. Study Selection and Data Extraction: 45 articles of potential relevance were selected. Results: 14 relevant papers were included. Most of studies including recent trials using Magnetic resonance imaging diffusion-weighted imaging fluid-attenuated inversion recovery (MRIDWI FLAIR) mismatch or Computed tomography …

Fibromyalgia: The Misunderstood Victim, Wajid Jawaid

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

County Incidence And Geospatial Trends Of Early-Onset Hypertensive Disorders Of Pregnancy In Kentucky, 2008-2017, Courtney J. Walker, Anna Kucharska-Newton, Steven R. Browning, W. Jay Christian

UK CARES Faculty Publications

Background Early‑onset hypertensive disorders of pregnancy (eHDP) are associated with more severe maternal and infant outcomes than later‑onset disease. However, little has been done to evaluate population‑level trends. Therefore, in this paper, we seek to address this understudied area by describing the geospatial and temporal patterns of county‑level incidence of eHDP and assessing county‑level demographics that may be associated with an increased incidence of eHDP.

Methods Employing Kentucky certificates of live and stillbirth from 2008–2017, this ecological study detected county‑level clusters of early‑onset hypertensive disorders of pregnancy using SaTScan, calculated average annual percent change (AAPC) with a join point analysis, …

Nursing News & Views - June 2023, Joanne Miller Rn

Nursing Newsletters

No abstract provided.

Prevalence And Predictors Of Suicidality Among Adults Initiating Office-Based Buprenorphine., Michelle R. Lent, Karen L Dugosh, Emily Hurstak, Hannah R. Callahan, Kimberly Mazur, Greater Philadelphia Opioid Use Disorder Research Group

PCOM Scholarly Works

BACKGROUND: Individuals who have substance use disorders may have an elevated risk of suicidality. This study sought to examine the prevalence of, and identify factors associated with, suicidality in adults with opioid use disorder (OUD) initiating office-based buprenorphine treatment.

METHODS: Individuals were eligible to participate if they had OUD and had initiated treatment in the past month. Participants (n = 244) completed a semi-structured interview using the Addiction Severity Index-Lite.

RESULTS: At baseline, 37.70% of participants reported significant thoughts of suicide over their lifetime and 27.46% reported suicidal attempts over their lifetime. Logistic regression analyses were used to identify predictors …

Hydrogen-Bonding Trends In A Bithiophene With 3- And/Or 4-Pyridyl Substituents, Alison M. Costello, Rebekah Duke, Stephanie Sorensen, Nadeesha Kothalawala, Moses Ogbaje, Nandini Sarkar, Doo Young Kim, Chad Risko, Sean Parkin, Aron J. Huckaba

UK CARES Faculty Publications

To improve the charge-carrier transport capabilities of thin-film organic materials, the intermolecular electronic couplings in the material should be maximized. Decreasing intermolecular distance while maintaining proper orbital overlap in highly conjugated aromatic molecules has so far been a successful way to increase electronic coupling. We attempted to decrease the intermolecular distance in this study by synthesizing cocrystals of simple benzoic acid coformers and dipyridyl-2,2′- bithiophene molecules to understand how the coformer identity and pyridine N atom placement affected solid-state properties. We found that with the 5-(3-pyridyl)-5′-(4-pyridyl)-isomer, the 4- pyridyl ring interacted with electrophiles and protons more strongly. Synthesized cocrystal powders …

In The Name Of Riwaj: An Ethnographic Study To Explore The Notion Of Women Empowerment Among Bisp Recipients In Rural Sakhro-Sindh, Pakistan, Qurratulain Nasiruddin, Rozina Karmaliani, Nasim Zahid Shah, Tazeen Saeed Ali

School of Nursing & Midwifery

Women empowerment is a national agenda for Pakistan and, one of its manifestations is the nationwide cash transfer program namely Benazir Income Support Programme (BISP). With the help of Bourdieu methodological paradigm of “habitus” this paper analyses empowerment among BISP recipients in their social settings where various social actors such as her husband and wadera of the village dominate her agency but, at the same time, women herself submits her agency to these social actors under the veil of riwaj (social customs). This ethnographic study reveals that the performance of submission among women follows an inner drive for conformation to …

Improvement Of Community Health Worker Counseling Skills Through Early Childhood Development (Ecd) Videos, Supervision And Mentorship: A Mixed Methods Pre-Post Evaluation From Tanzania, Josephine Pascal Ferla, Michelle M. Gill, Teopista Komba, Amina Abubakar, Pieter Remes, Ola Jahanpour, Gretchen Antelman

Institute for Human Development, East Africa

Background: Community health workers (CHWs) play significant roles in improving health practices in under- resourced communities. This study evaluated an early childhood development (ECD) project in Tanzania assessing the effect of mobile video use, supervision and mentorship to improve quality of CHW counseling skills.

Methods: CHWs participating in the Malezi Project in Tabora Region were enrolled in a mixed methods pre-post evaluation. CHWs previously trained in UNICEF’s Care for Child Development package were further trained in counselling caregivers on nurturing care and father engagement using videos. Health providers were trained to provide ECD-focused supervision/mentorship of CHWs in facilities and …

Navigating Life With Hiv As An Older Adult On The Kenyan Coast: Perceived Health Challenges Seen Through The Biopsychosocial Model, Patrick Mwangala, Ryan G. Wagner, Charles Newton, Amina Abubakar

Institute for Human Development, East Africa

Objectives: This study explores the perceptions of adults living with HIV aged ≥50 years (recognized as older adults living with HIV—OALWH), primary caregivers and healthcare providers on the health challenges of ageing with HIV at Kilifi, a low literacy setting on the coast of Kenya.

Methods: We utilized the biopsychosocial model to explore views from 34 OALWH and 22 stakeholders on the physical, mental, and psychosocial health challenges of ageing with HIV in Kilifi in 2019. Data were drawn from semi-structured in-depth interviews, which were audio-recorded and transcribed. A framework approach was used to synthesize the data.

Results: Symptoms of …

Unilateral Agenesis Of Adnexa, Srinidhi Govindarajan, Poornima M Associate Professor, Rashmi H.S., Aishwarya Bhat

Digital Journal of Clinical Medicine

No abstract provided.

From Bridge To Destination? Ethical Considerations Related To Withdrawal Of Ecmo Support Over The Objections Of Capacitated Patients, Andrew Childress, Trevor Bibler, Bryanna Moore, Ryan H Nelson, Joelle Robertson-Preidler, Olivia Schuman, Janet Malek

Faculty and Staff Publications

Extracorporeal membrane oxygenation (ECMO) is typically viewed as a time-limited intervention-a bridge to recovery or transplant-not a destination therapy. However, some patients with decision-making capacity request continued ECMO support despite a poor prognosis for recovery and lack of viability as a transplant candidate. In response, critical care teams have asked for guidance regarding the ethical permissibility of unilateral withdrawal over the objections of a capacitated patient. In this article, we evaluate several ethical arguments that have been made in favor of withdrawal, including distributive justice, quality of life, patients' rights, professional integrity, and the Equivalence Thesis. We find that existing …

Development Of A Definition Of Postacute Sequelae Of Sars-Cov-2 Infection, Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. Mccomsey, Lisa Mccorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. M. Schulte, Rachel Atchley-Challenner, Recover Consortium Authors, Leora I. Horwitz, Andrea S. Foulkes

Saha Cardiovascular Research Center Faculty Publications

IMPORTANCE SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.

OBJECTIVE To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.

DESIGN, SETTING, AND PARTICIPANTS Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, …

Evaluation Of 3d Printing Technologies And 3d Printed Materials In The Use Of Orthotic And Prosthetic Devices, Cory Larson

Master of Science in Kinesiology

Additive Manufacturing (AM) is disrupting fabrication techniques, bringing new design possibilities with associated benefits of less waste, improved design, improved time management, and less cost. The field of Orthotics and Prosthetics (O&P) is investigating how 3D printing, a subset of AM, can be used for fabrication of O&P devices. Before this technology is fully accepted, it needs to go through rigorous testing to ensure the safety of the individuals using the devices and the longevity of the devices themselves to ensure long term-use as a viable option. Research needs to define which type of 3D printing technology and what printed …

A Pandemics Treaty: A Boon For Africa, Kafumu Kalyalya

Southern African Journal of Policy and Development

This article illustrates the weaknesses of the current global health framework. It highlights two pillars a new treaty regime ought to be built upon. The analysis seeks to establish how these pillars could have helped Africa during the pandemic and can indeed help Africa in future pandemics. The analysis suggests the need for a unified global health regime or pandemics’ treaty that promotes a level legal and political playing field regarding future pandemics. The treaty could focus on coordination of research and development; build a stronger global framework that reinforces legal obligations and norms; provide for universal access to medicines, …

Psychometric Properties Of The Suicide Behaviors Questionnaire-Revised (Sbq-R) In American Sign Language, Jared A. Embree, Amanda M. Hinson-Enslin, Kathy Taylor, Josephine Wilson

JADARA

Limited research has focused on the risk of suicide within the deaf community, and no published studies to date report SBQ-R scores in deaf populations. The purpose of this study was to adapt the Suicide Behaviors Questionnaire-Revised into American Sign Language (SBQ-R-ASL). After the translation protocol was completed, the SBQ-R-ASL was field-tested with 340 deaf individuals in a national sample. Data analysis indicated satisfactory validity and internal consistency, and a Principal Components Analysis resulted in one factor. Field-test data revealed a mean SBQ-R-ASL score of 8.76, which is above published cutoff scores for suicide risk. These findings demonstrate a crucial …

Impact Of An Expanded Definition Of Family History On Outcomes Of Active Surveillance For Prostate Cancer, Adam C. Schneider, Thenappan Chandrasekar, Nicholas Bowler, Ryan Fogg, Joon Yau Leong, Andrew Gusev, Linda H. Rodgers, Shelley R. Mccormick, Douglas M. Dahl, Jason A. Efstathiou, Michael L. Blute, Anthony L. Zietman, Chin-Lee Wu, Matthew R. Smith, Eliezer M. Van Allen, Adam S. Feldman, Keyan Salari

Department of Urology Faculty Papers

PURPOSE: Despite family history being an established risk factor for prostate cancer, the role of a broader definition of family history inclusive of not just prostate cancer but other genetically related malignancies has not been investigated in the active surveillance population. Here, we evaluate the impact of an expanded definition of family history on active surveillance outcomes.

MATERIALS AND METHODS: Patients undergoing active surveillance for prostate cancer at Massachusetts General Hospital from 1997-2019 with detailed data available on family cancer history were identified. Primary outcome was biopsy progression-free survival, and secondary outcomes were treatment-free survival, adverse pathological features at prostatectomy, …

Prenatal And Childhood Exposure To Organophosphate Pesticides And Behavior Problems In Adolescents And Young Adults In The Chamacos Study, Sharon K. Sagiv, Ana M. Mora, Stephen Rauch, Katherine R. Kogut, Carly Hyland, Robert B. Gunier, Asa Bradman, Julianna Deardorff, Brenda Eskenazi

Public and Population Health Faculty Publications and Presentations

Background: We previously reported associations of prenatal exposure to organophosphate (OP) pesticides with poorer neurodevelopment in early childhood and at school age, including poorer cognitive function and more behavioral problems, in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a birth cohort study in an agriculture community.

Objective: We investigated the extent to which early-life exposure to OP pesticides is associated with behavioral problems, including mental health, in youth during adolescence and early adulthood.

Methods: We measured urinary dialkylphosphates (DAPs), nonspecific OP metabolites, in urine samples collected from mothers twice during pregnancy (13 and 26 …

Summary Of: Why Did Some Rural Mainers Accept Novel Covid-19 Vaccines When Rolled Out In 2021, While Others Did Not?, Michael Kohut Phd, Liz Scharnetzki, Joseph Pajka, Elizabeth Jacobs, Kathleen Fairfield

Northern New England Clinical & Translational Research

Many people, especially in rural areas of the United States, choose not to receive novel COVID-19 vaccinations despite public health recommendations.

Understanding how people describe decisions to get vaccinated or not may help to address hesitancy.

Study @ "Decisions about adopting novel COVID-19 vaccines among White adults in" by Michael Kohut PhD, Liz Scharnetzki et al.

The Wear And Tear Of Racism: Self-Silencing From The Perspective Of Young Black Women, Jewel Scott Phd, Rn, Fnp-C, Kortney Floyd James, Dara D. Méndez, Ragan Johnson, Esa M. Davis

Faculty Publications

Context: Historically, Black women strategically employed silence to endure enslavement to the U.S., and other forms of racial violence. The current study aimed to understand contemporary perspectives on self-silencing. Objective: To explore young adult Black women's experiences of self-silencing and its potential impact on their physical and mental well-being. Methods: Data are from 16 semi-structured interviews with Black women ages 18 to 39 in southwest Pennsylvania conducted between October 2021 - May 2022. We analyzed the interviews using inductive thematic analysis. Results: We identified four themes: “Self-silencing is Inherited,” “Silencing Here and Now,” “Wear and Tear,” and “The Flip Side.” …

Higher Overall Intakes Are The Defining Feature Of Dietary Intakes In Nafld And Compared To The General Population, Catherine Properzi, Leon A. Adams, Johnny Lo, Jill L. Sherriff, Gary P. Jeffrey, Therese A. O’Sullivan

Research outputs 2022 to 2026

We aimed to compare the dietary intakes of Australian patients with non-alcoholic fatty liver disease (NAFLD) to general Australian population intake data and determine whether the intake of any nutrient or food group was able to predict the degree of steatosis. Dietary data from fifty adult patients with NAFLD were compared to intake data from the Australian Health Survey for energy, macronutrients, fat sub-types, alcohol, iron, folate, sugar, fibre, sodium and caffeine. Linear regression models adjusting for potential confounders (age, sex, physical activity and body mass index) were used to examine predictive relationships between hepatic steatosis (quantified via magnetic resonance …

Dietary Polyphenols, Metabolic Syndrome And Cardiometabolic Risk Factors: An Observational Study Based On The Dch-Ng Subcohort, Fabian Lanuza, Raul Zamora-Ros, Nicola P. Bondonno, Tomas Meroño, Agnetha Linn Rostgaard-Hansen, Gabriele Riccardi, Anne Tjønneland, Rikard Landberg, Jytte Halkjær, Cristina Andres-Lacueva

Research outputs 2022 to 2026

Background and aims: Polyphenol-rich foods have beneficial properties that may lower cardiometabolic risk. We aimed to prospectively investigate the relationship between intakes of dietary polyphenols, and metabolic syndrome (MetS) and its components, in 676 Danish residents from the MAX study, a subcohort of the Danish Diet, Cancer and Health–Next Generations (DCH-NG) cohort. Methods and results: Dietary data were collected using web-based 24-h dietary recalls over one year (at baseline, and at 6 and 12 months). The Phenol-Explorer database was used to estimate dietary polyphenol intake. Clinical variables were also collected at the same time point. Generalized linear mixed models were …

Mothers' Experiences Of A New Early Collaborative Intervention, The Eaci, In The Neonatal Period: A Qualitative Study, Charlotte Sahlén Helmer, Ulrika Birberg Thornberg, Thomas Abrahamsson, Evalotte Mörelius

Research outputs 2022 to 2026

Aim: To explore mothers' experiences of the EArly Collaborative Intervention. Background: Preterm birth puts a considerable emotional and psychological burden on parents and families. Parents to moderate and late premature infants have shorter stays at the neonatal intensive care unit and have described a need for support. The EArly Collaborative Intervention was developed to support parents with preterm infants born between gestational Weeks 30 to 36. In this study, mothers' experiences of the new intervention were explored. Design: A qualitative design guided by a reflexive thematic analysis according to Braun and Clarke. Interviews were individually performed with 23 mothers experienced …

Diabetes Prevalence And Monitoring In Nonmetropolitan And Metropolitan Areas Within A Commercially Insured U.S. Population, Lindsey R. Hammerslag, Jeffery Talbert

Rural & Underserved Health Research Center Publications

Overview of Key Findings

• Enrollees living in nonmetropolitan areas had 22% higher likelihood of having diabetes, even after controlling for factors like age and region.
• The prevalence of diabetes in 2019-2020 was 7.9% in nonmetropolitan areas and 6.2% in metropolitan areas.
• Annual hemoglobin A1c (HbA1c) testing occurred for 85.1% of nonmetropolitan and 85.7% of metropolitan enrollees with diabetes. After controlling for other factors, we found significantly lower testing for those in nonmetropolitan areas.
• For diabetic enrollees, having an HbA1c test in 2019 was associated with an 8% decrease in the likelihood of non-cardiovascular complications related to diabetes and a 6% …

Deaf Adults’ View Of Having Speech Language Therapy In Early Schooling, Ashley Greene, Diane Clark, G. Marissa Ramos, Caroline K. Koo, Megan B. Wimberly, Danielle Goyette

JADARA

Speech therapy and interactions with Speech Language Pathologists (SLPs) during early adolescence is a common experience of many Deaf individuals. The decision to attend speech therapy is typically made by their hearing parents in conjunction with medical and educational professionals who hold the view that deaf children need to fit into the hearing world (Harmon, 2013). With the American Speech-Language-Hearing Association (ASHA) showing that the majority of currently licensed SLPs work in school settings (ASHA, 2018) coupled with the fact that the majority of deaf children receive some speech therapy in their early schooling years, the team wanted to know …

Food Insecurity Among Deaf And Hard Of Hearing: A Scoping Review, Rylea Saunders, Laportia Jackson, Julia Vandermolen

JADARA

The authors employed a scoping review to examine peer-reviewed journal articles published between 2017 and 2020 focusing on the relationship between food insecurity among deaf and hard of hearing (DHOH) populations and language barriers using American Sign Language (ASL). Four databases yielded 257 peer-reviewed articles during the initial search. Four peer-reviewed articles were included in the review to explore the relationship between food insecurity among DHOH populations and language barriers using ASL. Multiple contributing factors create a food-insecure individual. Results indicate that income level, mental health status, and caregiver communication are all predictors of food security for DHOH. One of …

Clinical Characteristics, Management, And 5-Year Survival Compared Between No Standard Modifiable Risk Factor (Smurfless) And ≥ 1 Smurf Acs Cases: An Analysis Of 15,051 Cases From Pakistan, Sana Sheikh, Ghazal Peerwani, Bashir Hanif, Salim S. Virani

Section of Cardiology

Background: There has been an increase in Acute Coronary Syndrome (ACS) patients without standard modifiable risk factors i.e. hypertension, diabetes, dyslipidemia, and tobacco use (SMuRFless) compared to the patients with ≥ 1 SMuRF but this has not been studied in South Asia despite them being a high-risk population. We conducted a comparative analysis of first episodes of ACS cases admitted to a tertiary cardiac center in Pakistan between SMuRFless and ≥ 1 SMuRF patients for clinical presentation, management, in-hospital, and 5-year mortality.
Methods: We undertook a retrospective study and data of 15,051 patients admitted at Tabba Heart Institute (THI) with …

Comparison Of Mandibular Fractures Caused By Violent Mechanisms Versus Nonviolent Mechanisms, Adam Schwartz, Jared Troy, D'Arcy Wainwright, Julie Park, Devon Durham, William West Iii, Rachel Su

USF-LVHN SELECT

No abstract provided.

Perioperative Complications Of Tcar Vs. Cea:A Pilot Study, Varun Konanki, Catherine M. Zatorski Md, Babak Sadri Md, Mila H. Ju Md

USF-LVHN SELECT

No abstract provided.

Neoadjuvant Chemotherapy For Resectableoncologicallyhigh-Risk Biliary Tract Cancers, Megan Satyadi, Jason Denbo, Kelvin Allenson, Samer Naffouje, Sarah Zhu, Richard Kim, Dae Won Kim, Gregory Lauwers, Daniel Anaya

USF-LVHN SELECT

No abstract provided.

Robotic Versus Laparoscopic Colorectal Surgery Experience At A Community-Based Teaching Hospital, Jill Scheurman, William Sangster Md, Shae Duka Mph, Erica Hallman

USF-LVHN SELECT

No abstract provided.