Medicine and Health Sciences Commons^™

Methicillin-Resistant Staphylococcus Aureus Screening Of Neonatal Intensive Care Unit Staff In An Outbreak Setting, R. Scott Stienecker Md, Fidsa, Fshea, Cic, Brittany S. Thorp Mph

Infection Control

Presented at 2023 APIC Annual Conference

In December 2020, our infection prevention (IP) department noted an increase in Methicillin-resistant Staphylococcus aureus (MRSA) isolates over baseline in the Neonatal Intensive Care Unit (NICU). Our hospital sees a steady influx of parents colonized with MRSA and our weekly screening process regularly discovers neonates that subsequently become colonized with MRSA. A doubling of the number of cases per month led to deeper investigation. Epidemiologic data were collected on the neonates and matched to their mother’s screening cultures (when obtained). Sensitivity patterns were matched, and staff noted that a single sensitivity pattern predominated

Medical School Watercooler Newsletter - June 1, 2023, Lindsey Lyle

Watercooler Newsletter

This is the June 1, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Whiddon college of medicine grieves passing of first chair of pharmacology
• Residents and fellows present at annual academic exposition
• Meet a Med Student: Kelly Blacksher
• Sehgal earns national citation for critical care medicine contributions

Musculoskeletal Injury In American Football: A Bibliometric Analysis Of The Most Cited Articles., Sohil S. Desai, Craig S. Dent, Dany B. El-Najjar, Hasani W. Swindell, Charles A. Popkin

HPD Articles

BACKGROUND: Textbook knowledge and clinical dogma are often insufficient for effective evidence-based decision making when treating musculoskeletal injuries in American football players, given the variability in presentation and outcomes across different sports and different levels of competition. Key evidence can be drawn directly from high-quality published articles to make the appropriate decisions and recommendations for each athlete's unique situation.

PURPOSE: To identify and analyze the 50 most cited articles related to football-related musculoskeletal injury to provide an efficient tool in the arsenal of trainees, researchers, and evidence-based practitioners alike.

STUDY DESIGN: Cross-sectional study.

METHODS: The ISI Web of Science and …

Visualizing Drug-Induced Lipid Accumulation In Lysosomes Of Live Cancer Cells With Stimulated Raman Imaging, Yuhao Yuan, Emmanuel O. Olawode, L. Nathan Tumey, Fake Lu

Pharmacy Faculty Scholarship

The low pH of the lysosomal compartment often results in sequestration of chemotherapeutic agents that contain positively charged basic functional groups, leading to anti-cancer drug resistance. To visualize drug localization in lysosomes and its influence on lysosomal functions, we synthesize a group of drug-like compounds that contain both a basic functional group and a bisarylbutadiyne (BADY) group as a Raman probe. With quantitative stimulated Raman scattering (SRS) imaging, we validate that the synthesized lysosomotropic (LT) drug analogs show high lysosomal affinity, which can also serve as a photostable lysosome tracker. We find that long-term retention of the LT compounds in …

Head Injury In Older Adults: To Scan Or Not To Scan? Ten Tips To Make The Best Decision, Audrey-Anne Brousseau, Éric Mercier

Journal of Geriatric Emergency Medicine

Ground-level falls are a leading cause of emergency department (ED) visits by older adults. In addition to understanding the cause of the fall, the assessment of potential fall-induced injuries such as traumatic intracranial hemorrhage, can be highly challenging for emergency clinicians. Premorbid conditions, medications and concomitant injuries can all interfere with the physical examination and impact the prevalence of signs traditionally associated with traumatic brain injury (TBI). When it comes to the decision to potentially investigate for a traumatic intracranial hemorrhage with a brain imaging such as a head computed tomography (CT), many potential predictors and factors will be considered. …

Himmelfarb Library Liaison Letter - June 2023, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Role Of Chronic Stress-Induced Neuroinflammation In Rodent Locus Coeruleus Physiology And Anxiety-Like Behaviors, Arthur Anthony Alfonso Reyes

Graduate School of Biomedical Sciences Theses and Dissertations

The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain region implicated in the stress response. Stress is a neuroendocrine physiologic response to a stressor that promotes organism survival through adaptive change and restoration of homeostasis. The central stress response, which drives behavioral and physiological change, is primarily mediated by activating the hypothalamic-pituitary-adrenal (HPA) axis. While advantageous in the short term, chronic stress exposure can lead to HPA axis and LC dysregulation, which are thought to contribute to the etiology of anxiety disorders. Previous studies demonstrate the effects of acute stress in increasing LC …

Bleeding Risk Assessment In Interventional Radiology., Nathaniel Bond

Doctor of Nursing Practice Papers

Abstract

Background: Interventional Radiology (IR) procedures vary in their bleeding risk. Staff responsible for screening patients in the preprocedural setting may not have adequate education regarding specific factors associated with increased bleeding risk specific to IR patients. Society of Interventional Radiology (SIR) consensus guidelines recommend the use of screening tools, but no tools specific to IR are currently available.

Objectives: To evaluate confidence of staff assessing bleeding risk prior to IR procedures and identify areas where further education may be needed.

Methods: A prospective cohort study design was used to conduct a staff confidence screening tool specific to IR staff …

Sinus Tract Vs. Fistula: There Is A Difference, Mea Weinberg Dmd, Msd, Rph, Stuart Segelnick Dds, Ms, Christine Chu Dds, Asgeir Sigurdsson Dds, Ms

The New York State Dental Journal

The terms sinus and fistula have been used interchangeably in clinical dentistry, but it may be inconsistent with past and current literature. The primary difference between the two is the number of anatomic spaces or openings involved. There is often confusion regarding the lining of a sinus tract and of a fistula. This article will review the clinical and histological features of a sinus and a fistula in both dentistry and medicine.

Building Up Cal Poly Global Brigades Student Group: Reflections On Designing And Implementing One Undergraduate-Led Community Info Session, Caroline Nicole Smith, Jafra D. Thomas

Kinesiology and Public Health

Intro: Global Brigades, an international non-profit organization, trains college students and other pre-professionals in community-based health promotion by mobilizing community service trips around the world, which are taught and led by local community groups. Cal Poly’s Global Brigades student group was founded in 2018, and thus far, they have carried out three annual, medically-focused brigades to Honduras (two in-person, one virtual).

Purpose: The aim of this report is to present the findings of one experiential senior project to promote Cal Poly’s Global Brigades student group^[1] (conducted January to March 2023).

Methods: The student designed material for …

Long-Term Outcomes Of Dual Vs Single Her2-Directed Neoadjuvant Therapy In Nsabp B-41., Priya Rastogi, Gong Tang, Saima Hassan, Charles E Geyer, Catherine A Azar, Gustav C Magrinat, J Marie Suga, Harry D Bear, Luis Baez-Diaz, Shakir Sarwar, Jean-Francois Boileau, Adam M Brufsky, Henry R Shibata, Hanna Bandos, Soonmyung Paik, Greg Yothers, Sandra M Swain, Eleftherios P Mamounas, Norman Wolmark

Oncology Articles

BACKGROUND: The primary aim of this randomized neoadjuvant trial in operable, HER2-positive breast cancer, was to determine the efficacy on pathologic complete response (pCR) of substituting lapatinib (L) for trastuzumab (T) or adding L to T, in combination with weekly paclitaxel (WP) following AC. Results on pCR were previously reported. Here, we report data on planned secondary endpoints, recurrence-free interval (RFI) post-surgery, and overall survival (OS).

METHODS: All patients received standard AC q3 weeks × 4 cycles followed by WP (80 mg/m

RESULTS: RFI at 4.5 years was 87.2%, 79.4% (p = 0.34; HR = 1.37; 95% CI 0.80, 2.34), …

College Of Health Sciences Newsletter, College Of Health Sciences, Old Dominion University

Ellmer College of Health Sciences Newsletters

June 2023 issue of Old Dominion University's College of Health Sciences Newsletter.

Resident Perspectives On The Value Of Rural General Surgery Rotations: It's Not Just About The Cases, Dorothy Hughes, Rebekah Wood, Randy Woods, Michael Sarap

Department of Surgery Faculty Publications

Purpose: Understand the scope of cases that residents participate in during rural general surgery rotations and the value residents and program directors find in such rotations. In turn, our goal is to add to the ongoing conversation the value exposure to rural surgery brings to surgery training. Methods: Qualitative study analyzed reviews of residents' self-reported case lists and field notes from exit interviews with the site director. Results: Trainees participated in an average of 105 cases during the rotation, including basic and advanced endoscopy along with exposure to a wide array of surgical cases. Residents had exposure to the rural …

Introduction, Lauri Deruiter-Willems, Nikki Hillier, Misty Rhoads, Amanda Harvey, Stacey Knight-Davis

Belonging, A photovoice project: Exhibit

Provides background to the Belonging project and an introduction to the social determinants of health.

Economic | Education, Lauri Deruiter-Willems, Misty Rhoads, Nikki Hillier, Amanda Harvey, Stacey Knight-Davis

Belonging, A photovoice project: Exhibit

Photos and short writings from Public Health & Nutrition undergraduate students describing the economic and education dimensions of the social determinants of health.

Endometriosis Eras, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Ethical Perspectives On Surgical Video Recording For Patients, Surgeons And Society: Systematic Review, Ross Walsh, Emma C. Kearns, Alice Moynihan, Sara Gerke, Mindy Duffourc, Marcelo Corrales Compagnucci, Timo Minssen, Ronan A. Cahill

Faculty Scholarly Works

Background

Operating-room audiovisual recording is increasingly proposed, although its ethical implications need elucidation. The aim of this systematic review was to examine the published literature on ethical aspects regarding operating-room recording.

Methods

MEDLINE (via PubMed), Embase, and Cochrane databases were systematically searched for articles describing ethical aspects regarding surgical (both intracorporeal and operating room) recording from database inception to the present (the last search was undertaken in July 2022). Medical subject headings used in the search included ‘operating room’, ‘surgery’, ‘video recording’, ‘black box’, ‘ethics’, ‘consent’, ‘confidentiality’, ‘privacy’, and more. Title, abstract, and full-text screening determined relevance. The quality of …

New Dentist News (June 2023), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Innovative Strategy To Improve Enteral Nutrition In Prone Positioning With Patients With Covid-19., Jan Powers Phd, Rn, Ccrn, Janette Richardson, Jennifer Rechter Msn, Rn-Bc, Agcns-Bc

Nursing Publications, Posters, & Presentations

BACKGROUND: Enteral nutrition is essential to improve outcomes in patients who are critically ill. Patients in the prone position, including those diagnosed with coronavirus disease 2019 (COVID-19) present additional challenges for enteral nutrition initiation.

METHODS: A novel technique for placing feeding tubes while in the prone position was developed using an electromagnetic placement device and specialty trained clinical nurse specialists. Data were assessed retrospectively to determine effectiveness of this new practice.

RESULTS: Sixty-eight patients had feeding tubes placed while in the prone position; 75% were able to be placed through the postpyloric route, 22% were placed through the gastric route, …

Refugee Women’S Receptiveness For Virtual Engagement On Reproductive Health During The Covid-19 Pandemic, Heike Thiel De Bocanegra, Zahra Goliaei, Nossin Khan, Sereen Banna, Rawnaq Behnam, Sheila K Mody

Faculty Publications & Research of the TUC Public Health Program

BACKGROUND: Refugee women who leave their country due to persecution and violence have multiple barriers to sexual and reproductive health (SRH) services. The COVID-19 pandemic added an additional barrier to in-person reproductive health education, dialogue, and clinical care. This study aimed to assess the potential of using virtual group meetings as a forum for refugee women to learn about and discuss reproductive health concerns such as cervical cancer screening, family planning, childbirth, and postpartum care.

METHOD: We conducted semi-structured interviews with 36 refugee women and stakeholders to assess factors that impact refugee women's receptiveness for virtual platforms to obtain information …

A Shared Decision-Making Process Utilizing A Decision Coach In Pediatric Epilepsy Surgery, Michelle Kregel, Natalie Evans, Bonnie Wooten, Craig Campbell, Sandrine De Ribaupierre, Andrea Andrade

Paediatrics Publications

BACKGROUND & RATIONALE: The process to evaluate candidacy for epilepsy surgery is lengthy and stressful for caregivers, therefore the decision can be challenging. There is not a lot of information in regard to how families of a child living with epilepsy navigate the stressful decision during surgical candidacy evaluation. With difficult decisions comes the possibility of increased decisional conflict in both the child and the family.

METHODS: A project designed to provide greater knowledge to the family was conducted utilizing the shared decision-making (SDM) process to assist families in the decision-making during surgical candidacy evaluation; this was done using a …

The Role Of Geography And Distance On Physician Follow-Up After A First Hospitalization With A Diagnosis Of A Schizophrenia Spectrum Disorder: A Retrospective Population-Based Cohort Study In Ontario, Canada, Kelly Anderson, Martin Rotenberg, Peter Gozdyra, Paul Kurdyak

Data and Test Instruments

No abstract provided.

Effect Of Different Implants Number And Distributions Used To Assist Mandibular Complete Overdenture: A Study Of Bite, Eslam Helmi, Elsayed Abdelkhalek, Ahmed Habib

Mansoura Journal of Dentistry

Objective: This within-patient study aimed to evaluate the influence of different numbers and distribution of implants used to assist mandibular complete overdenture on a patient's maximum biting force and masticatory efficiency. Materials and Methods: Six healthy completely edentulous patients were selected for this study. Each patient received a conventional complete denture then four implants were installed in the canine and premolar areas bilaterally. The implants were delayed loaded by mandibular overdenture using locator attachments, patients were classified into Group I: anterior two implants loaded by the overdenture; Group II: posterior two implants loaded by the overdenture; and Group III: four …

Nanoparticle Approaches For The Renin-Angiotensin System, Sajini D. Hettiarachchi, Young M. Kwon, Yadollah Omidi, Robert C. Speth

HPD Articles

The renin-angiotensin system (RAS) is a hormonal cascade that contributes to several disorders: systemic hypertension, heart failure, kidney disease, and neurodegenerative disease. Activation of the RAS can promote inflammation and fibrosis. Drugs that target the RAS can be classified into 3 categories, AT1 angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, and renin inhibitors. The therapeutic efficacy of current RAS-inhibiting drugs is limited by poor penetration across the blood-brain barrier, low bioavailability, and to some extent, short half-lives. Nanoparticle-mediated drug delivery systems (DDSs) are possible emerging alternatives to overcome such limitations. Nanoparticles are ideally 1-100 nm in size and are …

Nicus In The Us: Levels Of Acuity, Number Of Beds, And Relationships To Population Factors., Roberta Pineda, Kati Knudsen, Courtney C. Breault, Elizabeth E. Rogers, Wendy J. Mack, Alicia Fernandez-Fernandez

HPD Articles

OBJECTIVE: To 1) define the number and characteristics of NICUs in the United States (US) and 2) identify hospital and population characteristics related to US NICUs.

STUDY DESIGN: Cohort study of US NICUs.

RESULTS: There were 1424 NICUs identified in the US. Higher number of NICU beds was positively associated with higher NICU level (p < 0.0001). Higher acuity level and number of NICU beds related to being in a children's hospital (p < 0.0001;p < 0.0001), part of an academic center (p = 0.006;p = 0.001), and in a state with Certificate of Need legislation (p = 0.023;p = 0.046). Higher acuity level related to higher population density (p < 0.0001), and higher number of beds related to increasing proportions of minorities in the population up until 50% minorities. There was also significant variation in NICU level by region.

CONCLUSIONS: This study contributes new knowledge by describing an updated registry of NICUs in the US in 2021 that can be used for comparisons and benchmarking.

Bronchiolitis, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Clinical Practice Guidelines)

No abstract provided.

The Shared Ethical Framework To Allocate Scarce Medical Resources: A Lesson From Covid-19, Ezekiel J. Emanuel, Govind C. Persad

Sturm College of Law: Faculty Scholarship

The COVID-19 pandemic has helped to clarify the fair and equitable allocation of scarce medical resources, both within and among countries. The ethical allocation of such resources entails a three-step process: (1) elucidating the fundamental ethical values for allocation, (2) using these values to delineate priority tiers for scarce resources, and (3) implementing the prioritisation to faithfully realise the fundamental values. Myriad reports and assessments have elucidated five core substantive values for ethical allocation: maximising benefits and minimising harms, mitigating unfair disadvantage, equal moral concern, reciprocity, and instrumental value. These values are universal. None of the values are sufficient alone, …

3rd Jakarta Annual Surgical Symposia: Comprehensive Surgical Update Proceeding Abstracts, Scientific Committee Jass

The New Ropanasuri Journal of Surgery

Introduction. The need for arteriovenous fistula (AVF) as access to hemodialysis is increasing, but the failure rate of AVF maturity is also relatively high. Umbilical cord mesenchymal stem cells (MSCs) have anti-inflammatory properties that can occur in homeostasis, repair, and regeneration in pathological responses caused by vascular injury. This study aims to determine how administering cord mesenchymal stem cells (MSC) affects vascular maturity based on Doppler ultrasound examination in AVF rabbit models.

Method. An experimental study proceeded using a local male rabbit (Lepus Domestica). The administration of umbilical cord mesenchymal stem cells was applied in situ on AVF and intravenously. …

Elevated Inos And 3'-Nitrotyrosine In Kaposi's Sarcoma Tumors And Mouse Model, Olga Vladimirova, Samantha Soldan, Chenhe Su, Andrew Kossenkov, Owen Ngalamika, For Yue Tso, John T. West, Charles Wood, Paul M. Lieberman

LSU-LCMC Cancer Center Faculty Publications

Kaposi's Sarcoma (KS) is a heterogenous, multifocal vascular malignancy caused by the human herpesvirus 8 (HHV8), also known as Kaposi's Sarcoma-Associated Herpesvirus (KSHV). Here, we show that KS lesions express iNOS/NOS2 broadly throughout KS lesions, with enrichment in LANA positive spindle cells. The iNOS byproduct 3-nitrotyrosine is also enriched in LANA positive tumor cells and colocalizes with a fraction of LANA-nuclear bodies. We show that iNOS is highly expressed in the L1T3/mSLK tumor model of KS. iNOS expression correlated with KSHV lytic cycle gene expression, which was elevated in late-stage tumors (>4 weeks) but to a lesser degree in …

Three New Actions Enter Legal Landscape, Lance Plunkett Jd, Llm

The New York State Dental Journal

Latest legal maneuvers cover a variety of fronts with potential impact on dental practices.