Medicine and Health Sciences Commons^™

Integrating Sleep Promotion Education Into Acute Care Orthopedics Occupational Therapy Practice: A Case Series Study, Rebecca Ludwig, Aaron M. Eakman, Catherine Siengsukon

The Open Journal of Occupational Therapy

Background: The occupation of sleep is frequently under-addressed by occupational therapists with their clients. This may be in part because of a lack of general training on addressing this occupational domain or a lack of education about the basics of sleep. The domain of sleep has been in the Occupational Therapy Practice Framework since 2008. However, it remains unclear how to address the domain of sleep in occupational therapy practice. Therefore, the purpose of this case series is to describe the practical application of sleep promotion education.

Methods: A practicing occupational therapist with sleep training provided sleep promotion …

Use Of A Performance-Based Occupational Therapy Assessment Of Executive Function With The Homeless Population: A Case Report, Emily Raphael-Greenfield, Kimberlee Baltich, Tess Wilson, Rebecca Lowinger

The Open Journal of Occupational Therapy

Background: An estimated 25% of the homeless population has a mental illness, which means that many experience cognitive problems that adversely impact basic and instrumental activities of daily living and goal attainment. This case report focused on the experience of an individual living in transitional housing who was evaluated with a performance-based occupational therapy assessment in the context of community-based interdisciplinary psychosocial care provided by a robust occupational therapy fieldwork program.

Method: This case report generally followed the CARE Case Report Guidelines and highlights the use of a standardized performance-based assessment and follow-up care suggested by test outcomes. …

Feasibility Of A Stress Reduction Program Among Foster Youth In College, Alexis Melinda Ferioli Morin, Jennifer E. Lape

The Open Journal of Occupational Therapy

Background: Foster youth endure traumatic adversities, which can lead to obstacles when transitioning to young adulthood and pursuing postsecondary education. This vulnerable population is required to navigate independent living while also managing stress that commonly arises from postsecondary education.

Method: A pre test, post test pilot design was employed to determine the potential impact and feasibility of an evidenced-based multi-factorial stress management program in reducing foster youth’s perceived stress during postsecondary education. Participants (n = 3) received one, 90-min individual occupational therapy session weekly over 6 weeks. Author-generated stress management surveys along with the Perceived Stress Scale …

Encounters With Ethical Problems During The First 5 Years Of Practice In Occupational Therapy: A Survey, Brenda S. Howard, Michele Govern, Alexandra M. Gambrel, Morgan Haney, Haylee Ottinger, Travis W. Rippe, Alyssa Earls

The Open Journal of Occupational Therapy

Background: Health care professionals face ethical problems in practice, but there is little research on types of ethical problems encountered or ethical problem resolution. This study explored ethical problems encountered by occupational therapists and occupational therapy assistants (OTAs) within the first 5 years of practice.

Method: Investigators sent a survey in cooperation with NBCOT to a sample of 7,800 occupational therapists and OTAs in multiple practice settings who were NBCOT certified within the past five years. The survey covered questions regarding ethical problems encountered in practice, including productivity and related issues, clinical decision-making and professional reasoning, therapeutic relationships, and …

Predictors Of Occupational Competence In People Hospitalized With Chronic Conditions, Melanie Morriss Tkach, Patricia Bowyer, Marsha Neville, Timothy J. Wolf, Gerald Goodman

The Open Journal of Occupational Therapy

Background: Chronic diseases limit participation in meaningful daily activities, roles, and routines, which can negatively impact occupational competence, a sense of self, and life satisfaction, especially when hospitalization is required to manage disease symptoms. Standardized measures of occupational competence and related functional, cognitive, and environmental factors may enhance occupational therapists’ ability to identify potential barriers to and make targeted recommendations for self- and health management in the community.

Method: This cross-sectional study investigated occupational competence in patients hospitalized with chronic conditions. The participants completed measures of occupational competence, values, self-care function, environmental impact, and functional cognition while hospitalized. …

Social Participation And Navigation With Adolescent And Young Adult Brain Tumor Survivors: Usability And Potential Benefits, Gary Bedell, Nicole Porter, Miranda Cullen, Zachary Gould, Stephanie Freeman

The Open Journal of Occupational Therapy

Background: This study examined the usability and potential benefits of Social Participation and Navigation (SPAN), a virtual coaching goal planning intervention, which was modified for adolescent and young adult (AYA) brain tumor survivors who often experience social participation challenges.

Methods: Four AYA brain tumor survivors participated in a brief trial of the modified SPAN consisting of four weekly coaching sessions with trained supervised occupational therapy graduate students and use of a website and web application to assist with goal planning and achievement. The participants rated their social participation and SPAN-specific skills pre/post program. The participants and parents completed 1-week …

Reflections From The Other Side Of Acute Care, Debbie Amini

The Open Journal of Occupational Therapy

An occupational therapist of 40 years experiences a traumatic event during her time in an acute care hospital. She journeys through a host of life-altering experiences, including cognitive decline, delusion, paranoia, and an inability to engage in her desired occupations. While on this journey and during reflections following her return home, she is able to see more clearly how an occupational therapist may have assisted with several of the major concerns she was experiencing, thus improving her well-being and quality of life. She is an Assistant Editor for the Open Journal of Occupational Therapy (OJOT) and this is her story.

Loss Of Pml Nuclear Bodies In Familial Amyotrophic Lateral Sclerosis-Frontotemporal Dementia, Francesco Antoniani, Marco Cimino, Laura Mediani, Jonathan Vinet, Enza M. Verde, Valentina Secco, Alfred Yamoah, Priyanka Tripathi, Eleonora Aronica, Maria Elena Cicardi, Davide Trotti, Jared Sterneckert, Anand Goswami, Serena Carra

Farber Institute for Neuroscience Faculty Papers

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The critical genetic players of ALS and FTD are the TARDBP, FUS and C9orf72 genes, whose protein products, TDP-43, FUS and the C9orf72-dipeptide repeat proteins, accumulate in form of cytoplasmic inclusions. The majority of the studies focus on the understanding of how cells control TDP-43 and FUS aggregation in the cytoplasm, overlooking how dysfunctions occurring at the nuclear level may influence the maintenance of protein solubility outside of the nucleus. However, protein quality control (PQC) systems that maintain protein homeostasis comprise …

Global, Regional, And National Burden Of Diabetes From 1990 To 2021, With Projections Of Prevalence To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2021, Kanyin Liane Ong, Lauryn K. Stafford, Susan A. Mclaughlin, Edward J. Boyko, Stein Emil Vollset, Amanda E. Smith, Bronte E. Dalton, Joe Duprey, Jessica A. Cruz, Hailey Hagins, Paulina A. Lindstedt, Amirali Aali, Yohannes Habtegiorgis Abate, Melsew Dagne Abate, Mohammadreza Abbasian, Zeinab Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Samar Abd Elhafeez, Rami Abd-Rabu, Deldar Morad Abdulah, Abu Yousuf Md Abdullah, Veincent Christian Pepito

Ateneo School of Medicine and Public Health Publications

Background

Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050.

Methods

Estimates of diabetes prevalence and burden were computed in …

Lower Urinary Tract Symptoms In Depression: A Review, Danyon J. Anderson, Alise Aucoin, Colton R. Toups, Devin Cormier, Matthew Mcdonald, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

School of Medicine Faculty Publications

Lower Urinary Tract Symptoms (LUTS) are frequently present in the general population as patients age with approximately a third of individuals experiencing LUTS during their lifetime. LUTS can be further defined as having any of the following symptoms: urinary hesitancy, straining, nocturia, increased urination frequency, and dysuria. LUTS has the potential for patients to contribute their symptoms to what can normally occur as we age. This can lead to a decrease in patients seeking care and could negatively impact patients’ health-related quality of life (HRQL). In conjunction with LUTS, we obtained from our analysis that LUTS and depression are closely …

Long-Term Outcomes In Patients With Chronic Lymphocytic Leukemia Treated With Ibrutinib: Focus On Hypertension And Cardiovascular Toxicity, Max J Gordon, Jade E Jones, Binsah George, Christine Peterson, Jan A Burger, Nitin Jain, Michael Keating, William G Wierda, Jean-Bernard Durand, Alessandra Ferrajoli

Faculty, Staff and Student Publications

BACKGROUND: Continuous ibrutinib administration is needed to maintain efficacy in patients with chronic lymphocytic leukemia (CLL) and, as such, long-term toxicity is a concern. The authors report the 5-year follow-up of patients with CLL who received treatment with ibrutinib with a focus on hypertension and cardiovascular toxicities.

METHODS: Patient characteristics were assessed, including blood pressure, cardiovascular disease, disease progression, and death. Univariate logistic regression analysis assessed the relation of patient characteristics and the development of new or worsened hypertension. The incidence of hypertensive outcomes was evaluated using competing risk. Survival was estimated using the Kaplan-Meier method.

RESULTS: Three hundred patients …

Tianeptine, An Antidepressant With Opioid Agonist Effects: Pharmacology And Abuse Potential, A Narrative Review, Amber N. Edinoff, Saveen Sall, Scott P. Beckman, Andrew D. Koepnick, Logan C. Gold, Eric D. Jackson, Danielle M. Wenger, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan D. Kaye

Pacific Faculty Work

Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA). Despite its lack of approval by the FDA, tianeptine has been distributed online and at small retail locations. The term “gas station drugs” refers to a wide range of substances typically available for purchase from gas stations, corner stores, …

The Cerebellum Contributes To Generalized Seizures By Altering Activity In The Ventral Posteromedial Nucleus, Jaclyn Beckinghausen, Joshua Ortiz-Guzman, Tao Lin, Benjamin Bachman, Luis E Salazar Leon, Yu Liu, Detlef H Heck, Benjamin R Arenkiel, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Thalamo-cortical networks are central to seizures, yet it is unclear how these circuits initiate seizures. We test whether a facial region of the thalamus, the ventral posteromedial nucleus (VPM), is a source of generalized, convulsive motor seizures and if convergent VPM input drives the behavior. To address this question, we devise an in vivo optogenetic mouse model to elicit convulsive motor seizures by driving these inputs and perform single-unit recordings during awake, convulsive seizures to define the local activity of thalamic neurons before, during, and after seizure onset. We find dynamic activity with biphasic properties, raising the possibility that heterogenous …

Prevalence Of Overweight And Obesity Among Students Of Intermediate Schools In Basra : Prevalence Of Overweight And Obesity Among Students Of Intermediate Schools In Basra, Ziyad Shwaish, Mahmood Alatbee, Wefak Hasan Al-Kawaz, Nada Hasan Al-Kawaz

Iraqi National Journal of Medicine

Background: Obesity is one of the most serious public health challenges of the 21st century and represents a serious health problem for low- and middle-income countries, particularly in urban settings. Its prevalence has increased at an alarming rate. Globally, more than 340 million children and adolescents aged 5–19 years are overweight or obese, and approximately two-third of them live in developing countries. Aim: The present study was implemented to assess the prevalence rates of overweight and obesity among adolescents in intermediate schools in Basrah, Iraq. Methods: A cross-sectional study was conducted during the second semester (between January 15 and May …

Etiological Factors Of Hoarseness In Patients Attending Basrah General Hospital: Etiological Factors Of Hoarseness In Patients Attending Basrah General Hospital, Mueen Al Abdullah, Esam Al Sharieda, Hasanain Al-Ali

Iraqi National Journal of Medicine

Background: Hoarseness is a common symptom in otolaryngology practice, and it’s the earliest manifestation of a large variety of conditions directly or indirectly affecting the larynx, ranging from benign to most malignant. Aim: This study was undertaken to find out a clinical profile, the incidence of common predisposing and etiological factors of hoarseness. Methods: Two hundred cases of hoarseness for 18 months were studied. All cases were analyzed for detailed history and examination with visualization of the larynx through rigid video laryngoscopy or flexible nasopharyngolaryngoscopy and in some cases, direct laryngoscopy and biopsy were taken for histopathological study. The final …

Ototoxicity In Cancer Patients On Cisplatin Therapy Attending Basrah Oncology Centre: A Cohort Study: Ototoxicity In Cancer Patients On Cisplatin Therapy, Hasanain Al-Ali, Jasim Al-Asadi, Abdulrazzaq Alrubaye, Hasson Ali

Iraqi National Journal of Medicine

Background: Cisplatin is a chemotherapeutic agent that is used extensively for the treatment of a broad spectrum of tumors. However, progressive irreversible side effects of Cisplatin, including ototoxicity, have been reported. Methods: A cohort study was implemented from 1 April to 30 August 2015 to study the association between Cisplatin chemotherapy and sensory-neural hearing loss as the major and most important sign of ototoxicity. The cohort group included cancer patients treated with Cisplatin, while patients on Carboplatin were the control group. Cisplatin and Carboplatin belong to alkylating platinum chemotherapy drugs, which are used to treat various malignant solid tumors. Data …

Preparation And Characterization Of L-Ascorbic Acid Ethosomal Formulation For Enhancement Of Permeation: Preparation And Characterization Of L-Ascorbic Acid Ethosomal Formulation For Enhancement Of Permeation, Ahmed Alabada, Murtadaa Mohammed

Iraqi National Journal of Medicine

Background: Vesicular system is a good approach to improve hydrophilic drug permeability using phospholipids as Nanocarriers to increase lipophilicity and reduce vesicle size. L-ascorbic acid is a water soluble vitamin with antioxidant activity with poor skin permeability. Aim: The purpose of this work is to prepare LAA-containing ethosomes formulations utilizing a modified thin film hydration approach. Methods: eight formulas were prepared using different types of phospholipids (egg yolk lecithin and soya lecithin), different volumes of ethanol (2 and 3mL), and tween 80 as a surfactant. The prepared formulas (F1, F2, F3, F4, F5, F6, F7 and F8) were characterized to …

Correlation Of Placental Weight With Neonatal Weight And Hba1c In Normal Sudanese Pregnant Ladies In Alban-Jaded Teaching Hospital : Correlation Of Placental Weight With Neonatal Weight And Hba1c, Ibrahim Ali, Asim Osman, Wala Ahmed

Iraqi National Journal of Medicine

Background: The placenta is a life-supporting organ for the growing fetus. Several studies have highlighted the relationship between placental weight and neonatal birth weight; however, the role of glycosylated hemoglobin (HbA1c) has not been addressed. Aim: The study aimed to determine the relationship between the placental weight, neonatal birth weight, and HbA1c at term pregnancy in a Sudanese hospital. Methods: This was a cross-sectional hospital-based study conducted at Al Ban-Jaded Hospital between November and December 2022. Data, including the gestational age at delivery (in weeks), parity, mode of delivery, fetal birth weight, placental weight, fetal gender, and presence or absence …

Tuberculosis As A Complication Of Bcg In The Treatment Of Bladder Carcinoma: Tuberculosis As A Complication Of Bcg In The Treatment Of Bladder Carcinoma, Hiba Adnan Hameed, Mohammad Yahya Abdulrazaq, Abass Farhood Hussein

Iraqi National Journal of Medicine

Bacillus Calmette-Guérin (BCG), is a live attenuated strain of Mycobacterium bovis, and is the essential constituent of the vaccine against tuberculosis (TB) and adjuvant treatment for bladder cancer.  This vaccine has a potential pathogenic action; bacilli can cause recorded complications that can be located locally near the site of inoculation and at a distance through blood dissemination root. The BCG-related disease can represent a side effect of anti-TB vaccination in patients with acquired or congenital immunodeficiency or a complication of the therapeutic oncologic schedule in patients with malignancy. Here in we report three cases of BCG-related disease which visited our …

Phase 1b Study Of Combined Selinexor And Eribulin For The Treatment Of Advanced Solid Tumors And Triple-Negative Breast Cancer, Blessie Elizabeth Nelson, Sadia Saleem, Senthil Damodaran, Neeta Somaiah, Sarina Piha-Paul, Julia Ann Moore, Bulent Yilmaz, Deby Ogbonna, Daniel D Karp, Ecaterina Dumbrava, Apostolia M Tsimberidou, David S Hong, Jordi Rodon Ahnert, Denái R Milton, Xiaofeng Zheng, Daniel J Booser, Nuhad K Ibrahim, Anthony P Conley, Priya Bhosale, Cristhiam M Rojas Hernandez, Debasish Tripathy, Aung Naing, Funda Meric-Bernstam

Faculty, Staff and Student Publications

BACKGROUND: Selinexor (KPT-330) is a potent inhibitor of exportin 1 (XPO1), in turn inhibiting tumor growth. Selinexor enhances the antitumor efficacy of eribulin in triple-negative breast cancer (TNBC) in vitro and in vivo. Given the unmet medical need in TNBC and sarcoma, the authors explored the safety and efficacy of this combination.

METHODS: The authors conducted a phase 1b trial of combined selinexor and eribulin using a 3 + 3 dose-escalation design in patients who had advanced solid tumors and in those who had TNBC in a dose-expansion cohort.

RESULTS: Patients with TNBC (N = 19), sarcoma (N = 9), …

Five-Year Patient-Reported Outcomes In Nrg Oncology Rtog 0938, Evaluating Two Ultrahypofractionated Regimens For Prostate Cancer, Himanshu R Lukka, Snehal Deshmukh, Deborah W Bruner, Jean-Paul Bahary, Colleen A F Lawton, Jason A Efstathiou, Rajat J Kudchadker, Lee E Ponsky, Samantha A Seaward, Ian S Dayes, Darindra D Gopaul, Jeff M Michalski, Guila Delouya, Irving D Kaplan, Eric M Horwitz, Mack Roach, Felix Y Feng, Stephanie L Pugh, Howard M Sandler, Lisa A Kachnic

Faculty, Staff and Student Publications

PURPOSE: There is considerable interest in very short (ultrahypofractionated) radiation therapy regimens to treat prostate cancer based on potential radiobiological advantages, patient convenience, and resource allocation benefits. Our objective is to demonstrate that detectable changes in health-related quality of life measured by the bowel and urinary domains of the Expanded Prostate Cancer Index Composite (EPIC-50) were not substantially worse than baseline scores.

METHODS AND MATERIALS: NRG Oncology's RTOG 0938 is a nonblinded randomized phase 2 study of National Comprehensive Cancer Network low-risk prostate cancer in which each arm is compared with a historical control. Patients were randomized to 5 fractions …

Effectiveness Of Individualized Counseling On The Duration Of Exclusive Breastfeeding: Study Protocol For A Multicenter, Randomized, Parallel, And Open Clinical Trial., Mariana Torreglosa Ruiz, Elisa Da Conceição Rodrigues, Karine Emanuelle Peixoto Oliveira Da Silva, Cynthya Viana De Resende, Michele Curcino Cavalcanti, Luciano Marques Dos Santos, Monika Wernet, Ana Letícia Monteiro Gomes, Marialda Moreira Christoffel, Maria Beatriz Guimarães Raponi, Jéssica Aparecida Da Silva, Jacqueline Faria De Oliveira, Divanice Contim, Ana Linares

Nursing Faculty Publications

BACKGROUND: Despite the benefits of breastfeeding, early weaning is a reality, so less than 50% of children worldwide and in Brazil are on exclusive breastfeeding in the sixth month of life. A strategy to counteract this scenario is breastfeeding counseling. This study aims to verify the effectiveness of individualized counseling by nurses trained in breastfeeding counseling, on the duration of exclusive breastfeeding, compared to standard care.

METHODS: Multicenter, randomized, parallel, and open clinical trial, with primiparous women aged over 18 years, hospitalized in rooming-in wards at participating centers and hemodynamically stable, aware, and oriented, who had a single-fetus pregnancy and …

Actionability Classification Of Variants Of Unknown Significance Correlates With Functional Effect, Amber Johnson, Patrick Kwok-Shing Ng, Michael Kahle, Julia Castillo, Bianca Amador, Yujia Wang, Jia Zeng, Vijaykumar Holla, Thuy Vu, Fei Su, Sun-Hee Kim, Tara Conway, Xianli Jiang, Ken Chen, Kenna R Mills Shaw, Timothy A Yap, Jordi Rodon, Gordon B Mills, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Genomically-informed therapy requires consideration of the functional impact of genomic alterations on protein expression and/or function. However, a substantial number of variants are of unknown significance (VUS). The MD Anderson Precision Oncology Decision Support (PODS) team developed an actionability classification scheme that categorizes VUS as either "Unknown" or "Potentially" actionable based on their location within functional domains and/or proximity to known oncogenic variants. We then compared PODS VUS actionability classification with results from a functional genomics platform consisting of mutant generation and cell viability assays. 106 (24%) of 438 VUS in 20 actionable genes were classified as oncogenic in functional …

Presence Of Circulating Tumor Cells Predates Imaging Detection Of Relapse In Patients With Stage Iii Melanoma, Anthony Lucci, Sridevi Addanki, Yi-Ju Chiang, Salyna Meas, Vanessa N Sarli, Joshua R Upshaw, Mayank Manchem, Sapna P Patel, Jennifer A Wargo, Jeffrey E Gershenwald, Merrick I Ross

Faculty, Staff and Student Publications

Stage III melanoma includes nodal metastasis or in-transit disease. Five-year survival rates vary between 32% and 93%. The identification of high-risk patients is important for clinical decision making. We demonstrated previously that ≥1 circulating tumor cells (CTCs) at baseline was associated with recurrence. In this study, we investigated how frequently CTCs were identified prior to radiologically detected recurrence. Stage III patients (n = 325) had imaging at baseline and q 3 months. Baseline and q 6-12 months blood draws (7.5 mL) were performed to identify CTCs up to 3.5 years from diagnosis. CTC assessment was performed using the immunomagnetic …

Performance Of A Modified Fracture Risk Assessment Tool For Fragility Fracture Prediction Among Older Veterans Living With Hiv, Julie A Womack, Terrence E Murphy, Linda Leo-Summers, Farah Kidwai-Khan, Melissa Skanderson, Thomas M Gill, Barbara Gulanski, Maria C Rodriguez-Barradas, Phyllis C Tien, Michael T Yin, Evelyn Hsieh

Faculty, Staff and Students Publications

OBJECTIVE: Fragility fractures (fractures) are a critical outcome for persons aging with HIV (PAH). Research suggests that the fracture risk assessment tool (FRAX) only modestly estimates fracture risk among PAH. We provide an updated evaluation of how well a 'modified FRAX' identifies PAH at risk for fractures in a contemporary HIV cohort.

DESIGN: Cohort study.

METHODS: We used data from the Veterans Aging Cohort Study to evaluate veterans living with HIV, aged 50+ years, for the occurrence of fractures from 1 January 2010 through 31 December 2019. Data from 2009 were used to evaluate the eight FRAX predictors available to …

Are The Post-Covid-19 Posttraumatic Stress Disorder (Ptsd) Symptoms Justified By The Effects Of Covid-19 On Brain Structure? A Systematic Review, Georgios D Kotzalidis, Ottavia Marianna Ferrara, Stella Margoni, Valentina Ieritano, Antonio Restaino, Evelina Bernardi, Alessia Fischetti, Antonello Catinari, Laura Monti, Daniela Pia Rosaria Chieffo, Alessio Simonetti, Gabriele Sani

Faculty, Staff and Students Publications

COVID-19 affects brain function, as deduced by the "brain fog" that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic disease, continue to show posttraumatic stress disorder (PTSD) symptoms. We hypothesized that the persistent changes induced by COVID-19 on brain structure would overlap with those associated with PTSD. We performed a thorough PubMed search on 25 April 2023 using the following strategy: ((posttraumatic OR PTSD) AND COVID-19 AND (neuroimaging OR voxel OR VBM OR freesurfer …

Pediatric Phase 2 Trial Of A Wee1 Inhibitor, Adavosertib (Azd1775), And Irinotecan For Relapsed Neuroblastoma, Medulloblastoma, And Rhabdomyosarcoma, Kristina A Cole, Heba Ijaz, Lea F Surrey, Mariarita Santi, Xiaowei Liu, Charles G Minard, John M Maris, Stephan Voss, Joel M Reid, Elizabeth Fox, Brenda J Weigel

Faculty, Staff and Students Publications

BACKGROUND: Inhibition of the WEE1 kinase by adavosertib (AZD1775) potentiates replicative stress from genomic instability or chemotherapy. This study reports the pediatric solid tumor phase 2 results of the ADVL1312 trial combining irinotecan and adavosertib.

METHODS: Pediatric patients with recurrent neuroblastoma (part B), medulloblastoma/central nervous system embryonal tumors (part C), or rhabdomyosarcoma (part D) were treated with irinotecan and adavosertib orally for 5 days every 21 days. The combination was considered effective if there were at least three of 20 responses in parts B and D or six of 19 responses in part C. Tumor tissue was analyzed for alternative …

Deletion Of Taf1 And Taf5 In Zebrafish Capitulate Cardiac And Craniofacial Abnormalities Associated With Tafopathies Through Perturbations In Metabolism, Jamison Leid, Ryan Gray, Peter Rakita, Andrew L Koenig, Rohan Tripathy, James A J Fitzpatrick, Charles Kaufman, Lilianna Solnica-Krezel, Kory J Lavine

2020-Current year OA Pubs

Intellectual disability is a neurodevelopmental disorder that affects 2-3% of the general population. Syndromic forms of intellectual disability frequently have a genetic basis and are often accompanied by additional developmental anomalies. Pathogenic variants in components of TATA-binding protein associated factors (TAFs) have recently been identified in a subset of patients with intellectual disability, craniofacial hypoplasia, and congenital heart disease. This syndrome has been termed as a TAFopathy and includes mutations in TATA binding protein (TBP), TAF1, TAF2, and TAF6. The underlying mechanism by which TAFopathies give rise to neurodevelopmental, craniofacial, and cardiac abnormalities remains to be defined. Through a forward …

Associations Between Age, Sex, Apoe Genotype, And Regional Vascular Physiology In Typically Aging Adults, Nikou L Damestani, John Jacoby, Shrikanth M Yadav, Allison E Lovely, Aurea Michael, Melissa Terpstra, Marziye Eshghi, Barnaly Rashid, Carlos Cruchaga, David H Salat, Meher R Juttukonda

2020-Current year OA Pubs

Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood …

Cognitive And Neural Bases Of Visual-Context-Guided Decision-Making, Sai Sun, Hongbo Yu, Shuo Wang, Rongjun Yu

2020-Current year OA Pubs

Humans adjust their behavioral strategies based on feedback, a process that may depend on intrinsic preferences and contextual factors such as visual salience. In this study, we hypothesized that decision-making based on visual salience is influenced by habitual and goal-directed processes, which can be evidenced by changes in attention and subjective valuation systems. To test this hypothesis, we conducted a series of studies to investigate the behavioral and neural mechanisms underlying visual salience-driven decision-making. We first established the baseline behavioral strategy without salience in Experiment 1 (n = 21). We then highlighted the utility or performance dimension of the chosen …