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Articles 75481 - 75510 of 325315
Full-Text Articles in Medicine and Health Sciences
Comparative Outcomes Of Lung Volume Reduction Surgery And Lung Transplantation: A Systematic Review And Meta-Analysis, Danial Ahmad, Brandon E. Ferrell, Abhiraj Saxena, Diana C. Jiminez, Thomas J. O/Malley, Marco Dispagna, Vakhtang Tchantchaleishvili
Comparative Outcomes Of Lung Volume Reduction Surgery And Lung Transplantation: A Systematic Review And Meta-Analysis, Danial Ahmad, Brandon E. Ferrell, Abhiraj Saxena, Diana C. Jiminez, Thomas J. O/Malley, Marco Dispagna, Vakhtang Tchantchaleishvili
Department of Surgery Faculty Papers
Background: Lung volume reduction (LVR) and lung transplantation (LTx) have been used in different populations of chronic obstructive pulmonary disease (COPD) patients. To date, comparative study of LVR and LTx has not been performed. We sought to address this gap by pooling the existing evidence in the literature.
Methods: An electronic search was performed to identify all prospective studies on LVR and LTx published since 2000. Baseline characteristics, perioperative variables, and clinical outcomes were extracted and pooled for meta-analysis.
Results: The analysis included 65 prospective studies comprising 3,671 patients [LTx: 15 studies (n=1,445), LVR: 50 studies (n=2,226)]. Mean age was …
The Effect Of Sodium Bicarbonate On Acute Kidney Injury Markers During Physical Work In The Heat, Abdulaziz Abdulrahman A. Masoud, Fabiano Amorim, Christine Mermier, Michael Deyhle, Zidong Li
The Effect Of Sodium Bicarbonate On Acute Kidney Injury Markers During Physical Work In The Heat, Abdulaziz Abdulrahman A. Masoud, Fabiano Amorim, Christine Mermier, Michael Deyhle, Zidong Li
Health, Exercise, and Sports Sciences ETDs
Sodium bicarbonate supplementation (NaHCO3) before physical work in the heat may reduce the risk of developing acute kidney injury (AKI). Purpose: To determine the effects of NaHCO3 supplementation before a prolonged bout of physical work in the heat on AKI markers and kidney function. Method: A randomized, cross-over, double blinded design was conducted on 8 participants (3 females) who consumed NaHCO3 (0.2 g/kg body weight) or placebo (CON) before prolonged (120 minutes) moderate intensity (~65% of maximal heart rate) physical work in the heat [40℃ and 23% relative humidity (RH)]. Blood and urine samples were collected …
Identity, Structure, And Function Of The Mitochondrial Permeability Transition Pore: Controversies, Consensus, Recent Advances, And Future Directions, Paolo Bernardi, Christoph Gerle, Andrew P. Halestrap, Elizabeth A. Jonas, Jason Karch, Nelli Mnatsakanyan, Evgeny Pavlov, Shey-Shing Sheu, Alexander A. Soukas
Identity, Structure, And Function Of The Mitochondrial Permeability Transition Pore: Controversies, Consensus, Recent Advances, And Future Directions, Paolo Bernardi, Christoph Gerle, Andrew P. Halestrap, Elizabeth A. Jonas, Jason Karch, Nelli Mnatsakanyan, Evgeny Pavlov, Shey-Shing Sheu, Alexander A. Soukas
Center for Translational Medicine Faculty Papers
The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It is mediated by a non-selective channel, the mitochondrial permeability transition pore (mPTP). Sustained mPTP opening causes mitochondrial swelling, which ruptures the outer mitochondrial membrane leading to subsequent apoptotic and necrotic cell death, and is implicated in a range of pathologies. However, transient mPTP opening at various sub-conductance states may contribute several physiological roles such as alterations in mitochondrial bioenergetics and rapid Ca2+ efflux. Since its discovery decades ago, intensive efforts …
A Polycistronic System For Multiplexed And Precalibrated Expression Of Multigene Pathways In Fungi, Qun Yue, Jie Meng, Yue Qiu, Miaomiao Yin, Liwen Zhang, Weiping Zhou, Zhiqiang An, Zihe Liu, Qipeng Yuan, Wentao Sun, Chun Li, Huimin Zhao, István Molnár, Yuquan Xu, Shuobo Shi
A Polycistronic System For Multiplexed And Precalibrated Expression Of Multigene Pathways In Fungi, Qun Yue, Jie Meng, Yue Qiu, Miaomiao Yin, Liwen Zhang, Weiping Zhou, Zhiqiang An, Zihe Liu, Qipeng Yuan, Wentao Sun, Chun Li, Huimin Zhao, István Molnár, Yuquan Xu, Shuobo Shi
Faculty, Staff and Student Publications
Synthetic biology requires efficient systems that support the well-coordinated co-expression of multiple genes. Here, we discover a 9-bp nucleotide sequence that enables efficient polycistronic gene expression in yeasts and filamentous fungi. Coupling polycistronic expression to multiplexed, markerless, CRISPR/Cas9-based genome editing, we develop a strategy termed HACKing (Highly efficient and Accessible system by CracKing genes into the genome) for the assembly of multigene pathways. HACKing allows the expression level of each enzyme to be precalibrated by linking their translation to those of host proteins with predetermined abundances under the desired fermentation conditions. We validate HACKing by rapidly constructing highly efficient Saccharomyces …
Understanding The Factors Associated With Us Dermatology Resident Trainees’ Diagnostic Confidence And Skill For Skin Of Color Pathology, Alissa Jeanfreau, Kaylin Beiter, Deborah Hilton
Understanding The Factors Associated With Us Dermatology Resident Trainees’ Diagnostic Confidence And Skill For Skin Of Color Pathology, Alissa Jeanfreau, Kaylin Beiter, Deborah Hilton
School of Medicine Faculty Publications
Background: Inequities in dermatologic health outcomes translate to worsened clinical outcomes for minority groups. For example, despite a lower incidence of skin cancer overall, African Americans are diagnosed at later stages with greater degrees of lymph node involvement. This has been shown to lead to disproportionate mortality when compared to lighter skinned individuals. Medical education materials contain a significantly lower percentage of skin of color (SOC) images than of lighter skin and research has indicated lower diagnostic accuracy of dermatologic conditions in darker skin by U.S. medical students. The objective of this study was to explore U.S. resident dermatologists’ ability …
Hypertension Education To Enhance Health Literacy, Kylee Westrip
Hypertension Education To Enhance Health Literacy, Kylee Westrip
Student Scholarly Projects
Practice Problem: The health of patients suffers greatly when their health literacy is not addressed through evidence-based education material.
PICOT: The PICOT question that guided this project was, in adult patients with hypertension (P), how does evidence-based education material (I) compared to the current state of verbal instructions provided (C) affect health literacy rates based on the high blood pressure health literacy scale (O) within 12-weeks (T)?
Evidence: The literature evidence revealed three strong themes, which included information on who is most at risk for low health literacy levels, education delivery methods, and specific education to be used.
Intervention: …
Ancestry-Driven Metabolite Variation Provides Insights Into Disease States In Admixed Populations, Kaylia M Reynolds, Andrea R V R Horimoto, Bridget M Lin, Ying Zhang, Nuzulul Kurniansyah, Bing Yu, Eric Boerwinkle, Qibin Qi, Robert Kaplan, Martha Daviglus, Lifang Hou, Laura Y Zhou, Jianwen Cai, Saame Raza Shaikh, Tamar Sofer, Sharon R Browning, Nora Franceschini
Ancestry-Driven Metabolite Variation Provides Insights Into Disease States In Admixed Populations, Kaylia M Reynolds, Andrea R V R Horimoto, Bridget M Lin, Ying Zhang, Nuzulul Kurniansyah, Bing Yu, Eric Boerwinkle, Qibin Qi, Robert Kaplan, Martha Daviglus, Lifang Hou, Laura Y Zhou, Jianwen Cai, Saame Raza Shaikh, Tamar Sofer, Sharon R Browning, Nora Franceschini
Faculty, Staff and Student Publications
BACKGROUND: Metabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental factors. Hispanics/Latino individuals have ancestry-derived genomic regions (local ancestry) from their recent admixture that have been less characterized for associations with metabolite abundance and disease risk.
METHODS: We performed admixture mapping of 640 circulating metabolites in 3887 Hispanic/Latino individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Metabolites were quantified in fasting serum through non-targeted mass spectrometry (MS) analysis using ultra-performance liquid chromatography-MS/MS. Replication was performed in 1856 nonoverlapping HCHS/SOL participants with metabolomic data.
RESULTS: By leveraging local ancestry, this …
Anti-Mir-93-5p Therapy Prolongs Sepsis Survival By Restoring The Peripheral Immune Response, Mihnea P Dragomir, Enrique Fuentes-Mattei, Melanie Winkle, Keishi Okubo, Recep Bayraktar, Erik Knutsen, Aiham Qdaisat, Meng Chen, Yongfeng Li, Masayoshi Shimizu, Lan Pang, Kevin Liu, Xiuping Liu, Simone Anfossi, Huanyu Zhang, Ines Koch, Anh M Tran, Swati Mohapatra, Anh Ton, Mecit Kaplan, Matthew W Anderson, Spencer J Rothfuss, Robert Silasi, Ravi S Keshari, Manuela Ferracin, Cristina Ivan, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Constantin Georgescu, Pinaki P Banerjee, Rafet Basar, Ziyi Li, David Horst, Catalin Vasilescu, Maria Teresa S Bertilaccio, Katayoun Rezvani, Florea Lupu, Sai-Ching Yeung, George A Calin
Anti-Mir-93-5p Therapy Prolongs Sepsis Survival By Restoring The Peripheral Immune Response, Mihnea P Dragomir, Enrique Fuentes-Mattei, Melanie Winkle, Keishi Okubo, Recep Bayraktar, Erik Knutsen, Aiham Qdaisat, Meng Chen, Yongfeng Li, Masayoshi Shimizu, Lan Pang, Kevin Liu, Xiuping Liu, Simone Anfossi, Huanyu Zhang, Ines Koch, Anh M Tran, Swati Mohapatra, Anh Ton, Mecit Kaplan, Matthew W Anderson, Spencer J Rothfuss, Robert Silasi, Ravi S Keshari, Manuela Ferracin, Cristina Ivan, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Constantin Georgescu, Pinaki P Banerjee, Rafet Basar, Ziyi Li, David Horst, Catalin Vasilescu, Maria Teresa S Bertilaccio, Katayoun Rezvani, Florea Lupu, Sai-Ching Yeung, George A Calin
Faculty, Staff and Student Publications
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets for sepsis therapeutics, we used samples for miRNA array analysis of PBMCs from patients with sepsis and control individuals, blood samples from 2 cohorts of patients with sepsis, and multiple animal models: mouse cecum ligation puncture-induced (CLP-induced) sepsis, mouse viral miRNA challenge, and baboon Gram+ and …
The Checkpoint Inhibitor Pd-1h/Vista Controls Osteoclast-Mediated Multiple Myeloma Bone Disease, Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Gabriel M Pagnotti, Lewis M Brown, Stephen J Weiss, Markus Y Mapara, Suzanne Lentzsch
The Checkpoint Inhibitor Pd-1h/Vista Controls Osteoclast-Mediated Multiple Myeloma Bone Disease, Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Gabriel M Pagnotti, Lewis M Brown, Stephen J Weiss, Markus Y Mapara, Suzanne Lentzsch
Faculty, Staff and Student Publications
Multiple myeloma bone disease is characterized by the development of osteolytic bone lesions. Recent work identified matrix metalloproteinase 13 as a myeloma-derived fusogen that induces osteoclast activation independent of its proteolytic activity. We now identify programmed death-1 homolog, PD-1H, as the bona fide MMP-13 receptor on osteoclasts. Silencing PD-1H or using Pd-1h-/- bone marrow cells abrogates the MMP-13-enhanced osteoclast fusion and bone-resorptive activity. Further, PD-1H interacts with the actin cytoskeleton and plays a necessary role in supporting c-Src activation and sealing zone formation. The critical role of PD-1H in myeloma lytic bone lesions was confirmed using a Pd-1h-/- myeloma bone …
Many Pediatric Patients With Gastroparesis Do Not Receive Dietary Education, Debra Eseonu, Deepa Dongarwar, Hamisu Salihu, Bruno P Chumpitazi, Robert J Shulman
Many Pediatric Patients With Gastroparesis Do Not Receive Dietary Education, Debra Eseonu, Deepa Dongarwar, Hamisu Salihu, Bruno P Chumpitazi, Robert J Shulman
Faculty, Staff and Students Publications
BACKGROUND: Gastroparesis is delayed gastric emptying in the absence of obstruction; dietary modifications are first-line treatment. However, we do not know the factors related to provision of dietary recommendations.
METHODS: We sought to determine how often pediatric patients with gastroparesis receive dietary education (from a gastroenterology provider vs dietitian), the recommendations given, and factors related to these outcomes. We performed a retrospective chart review of children 2- to 18-years-old managed by pediatric gastroenterology providers at our institution. Patient demographics and clinical data, dietary advice given (if any), and dietitian consultation (if any), practice location, and prokinetic use were captured. An …
Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons In The Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C Bean, Yang He, Hailan Liu, Meng Yu, Hesong Liu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Kristine M Conde, Mengjie Wang, Yongxiang Li, Bing Feng, Peiyu Gao, Zhao-Lin Cai, Makoto Fukuda, Mingshan Xue, Qingchun Tong, Yongjie Yang, Lan Liao, Jianming Xu, Chunmei Wang, Yanlin He, Yong Xu
Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons In The Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C Bean, Yang He, Hailan Liu, Meng Yu, Hesong Liu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Kristine M Conde, Mengjie Wang, Yongxiang Li, Bing Feng, Peiyu Gao, Zhao-Lin Cai, Makoto Fukuda, Mingshan Xue, Qingchun Tong, Yongjie Yang, Lan Liao, Jianming Xu, Chunmei Wang, Yanlin He, Yong Xu
Faculty, Staff and Student Publications
Glucose is the basic fuel essential for maintenance of viability and functionality of all cells. However, some neurons - namely, glucose-inhibited (GI) neurons - paradoxically increase their firing activity in low-glucose conditions and decrease that activity in high-glucose conditions. The ionic mechanisms mediating electric responses of GI neurons to glucose fluctuations remain unclear. Here, we showed that currents mediated by the anoctamin 4 (Ano4) channel are only detected in GI neurons in the ventromedial hypothalamic nucleus (VMH) and are functionally required for their activation in response to low glucose. Genetic disruption of the Ano4 gene in VMH neurons reduced blood …
Nerve Transfer For Restoration Of Lower Motor Neuron-Lesioned Bladder, Urethral, And Anal Sphincter Function In A Dog Model. Part 3. Nicotinic Receptor Characterization, Nagat Frara, Mary F. Barbe, Dania Giaddui, Danielle S. Porreca, Alan S. Braverman, Ekta Tiwari, Attia Ahmad, Justin M. Brown, Benjamin R. Johnston, Stanley F. Bazarek, Michael R. Ruggieri
Nerve Transfer For Restoration Of Lower Motor Neuron-Lesioned Bladder, Urethral, And Anal Sphincter Function In A Dog Model. Part 3. Nicotinic Receptor Characterization, Nagat Frara, Mary F. Barbe, Dania Giaddui, Danielle S. Porreca, Alan S. Braverman, Ekta Tiwari, Attia Ahmad, Justin M. Brown, Benjamin R. Johnston, Stanley F. Bazarek, Michael R. Ruggieri
Department of Neurology Faculty Papers
Very little is known about the physiological role of nicotinic receptors in canine bladders, although functional nicotinic receptors have been reported in bladders of many species. Utilizing in vitro methods, we evaluated nicotinic receptors mediating bladder function in dogs: control (9 female and 11 male normal controls, 5 sham operated), Decentralized (9 females, decentralized 6–21 mo), and obturator-to-pelvic nerve transfer reinnervated (ObNT-Reinn; 9 females; decentralized 9–13 mo, then reinnervated with 8–12 mo recovery). Muscle strips were collected, mucosa-denuded, and mounted in muscle baths before incubation with neurotransmitter antagonists, and contractions to the nicotinic receptor agonist epibatidine were determined. Strip response …
Apoe-Ε4 Synergizes With Sleep Disruption To Accelerate Aβ Deposition And Aβ-Associated Tau Seeding And Spreading, Chanung Wang, Aishwarya Nambiar, Michael R. Strickland, Choonghee Lee, Samira Parhizkar, Alec C. Moore, Erik S. Musiek, Jason D. Ulrich, David M. Holtzman
Apoe-Ε4 Synergizes With Sleep Disruption To Accelerate Aβ Deposition And Aβ-Associated Tau Seeding And Spreading, Chanung Wang, Aishwarya Nambiar, Michael R. Strickland, Choonghee Lee, Samira Parhizkar, Alec C. Moore, Erik S. Musiek, Jason D. Ulrich, David M. Holtzman
2020-Current year OA Pubs
Alzheimer's disease (AD) is the most common cause of dementia. The APOE-ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD. The APOE genotype modulates the effect of sleep disruption on AD risk, suggesting a possible link between apoE and sleep in AD pathogenesis, which is relatively unexplored. We hypothesized that apoE modifies Aβ deposition and Aβ plaque-associated tau seeding and spreading in the form of neuritic plaque-tau (NP-tau) pathology in response to chronic sleep deprivation (SD) in an apoE isoform-dependent fashion. To test this hypothesis, we used APPPS1 mice expressing human APOE-ε3 …
Expressing Information Needs And Information Literacy Skills Amongst Final Year Undergraduate Students In Northern Nigeria, Zikrat Abdulsalam, Imoisili Ojeime Odigie
Expressing Information Needs And Information Literacy Skills Amongst Final Year Undergraduate Students In Northern Nigeria, Zikrat Abdulsalam, Imoisili Ojeime Odigie
Library Philosophy and Practice (e-journal)
Information literacy is the ability of an individual to locate, evaluate, and use information. This study expresses the conscious information needs and information literacy skills amongst final year undergraduate students of three Universities in Nigeria; being the Ahmadu Bello University (ABU), Federal University Lokoja (FUL), and Baze University. A survey research design alongside a questionnaire for the instrument were utilised on a sample size of 307 final year undergraduate students from select faculties within the above-mentioned universities. The findings of the study amongst other show that undergraduate students at the final year level had a conscious knowledge of their information …
Back To Basics: Improving The Quality Of Blood Pressure Measurement, Heather Sailor
Back To Basics: Improving The Quality Of Blood Pressure Measurement, Heather Sailor
Student Scholarly Projects
Practice Problem: Hypertension is a leading cause of death and disability worldwide. Blood pressure measurement (BPM) is at the forefront of diagnosing and treating hypertension, however, it is often measured inaccurately.
PICOT: The PICOT question that guided this project was: In outpatient adult patients (P), what is the effect of implementing a standardized blood pressure measurement protocol (I) versus standard measurement (C), on the quality of blood pressure measurement (O) within 8 weeks (T)?
Evidence: Implementation of a blood pressure measurement protocol has been shown to improve the quality of blood pressure measurement.
Intervention: A blood pressure measurement protocol …
Shared Governance And Transition Into Practice: Impact On Work Engagement, Gudrun M. Reiter-Hiltebrand
Shared Governance And Transition Into Practice: Impact On Work Engagement, Gudrun M. Reiter-Hiltebrand
Student Scholarly Projects
Practice Problem: High turnover rates, particularly in new graduate nurses, and poor organizational commitment and engagement negatively affect staffing, operational performance, and patient outcomes. A negative trend for nurse engagement indicators was noted in previous staff engagement surveys of this organization.
PICOT: The PICOT question that guided this project was: In transition-into-practice (TIP) nurses (P), how does the implementation of shared governance (I) compared with no shared governance participation (C), affect their engagement with the hospital (O) within eight weeks (T)?
Evidence: Literature has shown that nurse engagement is one of the nurse indicators positively affected by shared governance …
Faith And Information To Treat Hypertension, Tiffany Bell
Faith And Information To Treat Hypertension, Tiffany Bell
Student Scholarly Projects
Practice Problem: The prevalence of stroke and hypertension (HTN) in African Americans in the United States is among the highest in the world (American Heart Association, n.d.) with cultural norms as a contributing factor.
PICOT: The PICOT question that guided this project was in African American adults (>18 y/o) (P), how does a faith-based hypertension management program (I), compared to standard hypertension management (C), affect blood pressure measurements (O) within an 8-week timeframe (T)?
Evidence: The integration of motivational interviewing with therapeutic lifestyle changes along with HTN education using a community-based participatory approach delivered in the …
Identification Of Potential Non-Invasive Biomarkers In Diastrophic Dysplasia, Chiara Paganini, Ricki S. Carroll, Chiara Gramegna Tota, Andrea J. Schelhaas, Alessandra Leone, Angela L. Duker, David A. O'Connell, Ryan F. Coghlan, Brian Johnstone, Carlos R. Ferreira, Sabrina Peressini, Riccardo Albertini, Antonella Forlino, Luisa Bonafé, Ana Belinda Campos-Xavier, Andrea Superti-Furga, Andreas Zankl, Antonio Rossi, Michael B. Bober
Identification Of Potential Non-Invasive Biomarkers In Diastrophic Dysplasia, Chiara Paganini, Ricki S. Carroll, Chiara Gramegna Tota, Andrea J. Schelhaas, Alessandra Leone, Angela L. Duker, David A. O'Connell, Ryan F. Coghlan, Brian Johnstone, Carlos R. Ferreira, Sabrina Peressini, Riccardo Albertini, Antonella Forlino, Luisa Bonafé, Ana Belinda Campos-Xavier, Andrea Superti-Furga, Andreas Zankl, Antonio Rossi, Michael B. Bober
Student Papers, Posters & Projects
Diastrophic dysplasia (DTD) is a recessive chondrodysplasia caused by pathogenic variants in the SLC26A2 gene encoding for a cell membrane sulfate/chloride antiporter crucial for sulfate uptake and glycosaminoglycan (GAG) sulfation. Research on a DTD animal model has suggested possible pharmacological treatment approaches. In view of future clinical trials, the identification of non-invasive biomarkers is crucial to assess the efficacy of treatments. Urinary GAG composition has been analyzed in several metabolic disorders including mucopolysaccharidoses. Moreover, the N-terminal fragment of collagen X, known as collagen X marker (CXM), is considered a real-time marker of endochondral ossification and growth velocity and was studied …
Examining Treatment Differences In Anxiety Disorders And Body-Focused Repetitive And Related Disorders In A Pediatric Clinic Sample, Katrina Scarimbolo
Examining Treatment Differences In Anxiety Disorders And Body-Focused Repetitive And Related Disorders In A Pediatric Clinic Sample, Katrina Scarimbolo
USF Tampa Graduate Theses and Dissertations
Anxiety disorders are one of the most common mental health concerns that affect youth. It is estimated about 9.4% of youth have an anxiety disorder such as panic disorder, generalized anxiety disorder, social anxiety disorder, separation anxiety disorder or specific phobias (CDC, 2022). The present study includes obsessive compulsive disorder and post-traumatic stress disorder as a part of the definition of anxiety disorders. Anxiety disorders can be comorbid with many mental health conditions. The focus of this study was on the comorbidity between anxiety disorders and body-focused repetitive behaviors (BFRBs) and related disorders. BFRBs are behaviors that involve repeated picking, …
Temporal Trends And Geographic Variations In Mortality Rates From Tobacco And Firearms In The United States, Sarah A Palumbo, Robert S Levine, Janet D Robishaw, Charles H Hennekens
Temporal Trends And Geographic Variations In Mortality Rates From Tobacco And Firearms In The United States, Sarah A Palumbo, Robert S Levine, Janet D Robishaw, Charles H Hennekens
Faculty, Staff and Students Publications
We explored temporal trends and geographic variations in United States of America (US) mortality rates from smoking and firearms from 1999 to 2019. To do so, we used the publicly available Centers for Disease Control and Prevention (CDC) Wide Ranging Online Data for Epidemiologic Research (WONDER) with Multiple Cause of Death files from 1999 to 2019. Using age-specific rates and ArcGIS Pro Advanced software for Optimized Hot Spot Analyses from Esri, we generated maps of statistically significant spatial clusters with 90-99% confidence intervals with the Getis-Ord Gi* statistic for mortality from smoking-related causes and firearms. These data show temporal trends …
The Association Between Higher Expression Of Talin-1 And The Reduced Survival Rate In Ovarian Serous Carcinoma Patients, Mina Sharbatoghli, Leili Saeednejad Zanjani, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Medhi Totonchi, Mohsen Asadi-Lari, Zahra Madjd
The Association Between Higher Expression Of Talin-1 And The Reduced Survival Rate In Ovarian Serous Carcinoma Patients, Mina Sharbatoghli, Leili Saeednejad Zanjani, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Medhi Totonchi, Mohsen Asadi-Lari, Zahra Madjd
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Background & Objective: Talin-1 is a constituent of the multiprotein adhesion complexes that play main role in the formation of tumors and migration in different types of malignancies. The present study aimed to assess expression and prognostic significance of the talin-1 protein in ovarian serous carcinoma (OSC) patients.
Methods: The expression of talin-1 in mRNA and its protein levels were investigated for ovarian cancer (OC) by using bioinformatics tools, including Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Gene Expression Database of Normal and Tumor Tissue 2 (GENT2), and The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN) databases. …
Developing A Holistic Outlook Through Art, Jennifer K. Fortuna
Developing A Holistic Outlook Through Art, Jennifer K. Fortuna
The Open Journal of Occupational Therapy
Dr. Guy McCormack, PhD., OTR/L, FAOTA, an occupational therapist and retired academic program director based in Seaside, California, provided the cover art for the Summer 2023 edition of The Open Journal of Occupational Therapy (OJOT). “Tree of Life” is a 20” x 24” painting made from acrylic on panel. McCormack has served as an occupational therapist and educator for nearly 50 years. His career includes many notable clinical and academic achievements. Today, he finds joy in painting landscapes, animals, and abstract compositions. Since his retirement, art has helped McCormack develop a more holistic outlook on life.
Letter To The Editor: Re: Burke, Bundy, & Lane (2023) Article “If Reasoning, Reflection, And Evidence-Based Practice Are Essential To Practice, We Must Define Them”, Angela Benfield, Mark V. Johnston
Letter To The Editor: Re: Burke, Bundy, & Lane (2023) Article “If Reasoning, Reflection, And Evidence-Based Practice Are Essential To Practice, We Must Define Them”, Angela Benfield, Mark V. Johnston
The Open Journal of Occupational Therapy
The purpose of this letter to the editor is to suggest using modern test theory to support developing empirical definitions of these complex terms.
The Promise Of Occupational Therapy: Occupational Engagement, Daniel Cezar Da Cruz
The Promise Of Occupational Therapy: Occupational Engagement, Daniel Cezar Da Cruz
The Open Journal of Occupational Therapy
Occupational engagement was first described in 1980 by Elizabeth Yerxa. Forty years later, the concept has no consensual definition in the literature. Despite a lack of common agreement, occupational engagement has been used to describe the ultimate goal of occupational therapy in several documents of associations and research articles. The opinion piece discusses the importance and implications of a lack of consensual concept definition for the profession of occupational therapy and focuses on five descriptions of occupational engagement in the literature. The word "promise" expresses the message occupational therapists send through their organizations, institutions, clinical practice, and research to society …
Applying The Ecological Model Of Human Performance And The Slutwalk Movement To Support Those Affected By Rape Culture In The Context Of Occupational Therapy, Angela Klukken, Sally Wasmuth
Applying The Ecological Model Of Human Performance And The Slutwalk Movement To Support Those Affected By Rape Culture In The Context Of Occupational Therapy, Angela Klukken, Sally Wasmuth
The Open Journal of Occupational Therapy
Improving the occupational lives of others is at the heart of occupational therapy practice. Advocacy for clientele is central to this improvement, both at individual and structural levels. We argue that interventions in the Ecological Model of Human Performance (EHP) and the social movement theSlutWalk can offer increased opportunity for occupational therapists to address the harmful implications for clients affected by sexual assault and rape culture. In addition, through the principles of the EHP and the SlutWalk, we propose that occupational therapists can have a hand in eradicating the culture that facilitates and tolerates sexual violence. This paper …
The Canadian Occupational Performance Measure (Copm): Critiquing Its Applicability With Indigenous Peoples And Communities, Tara Price, Tara Pride
The Canadian Occupational Performance Measure (Copm): Critiquing Its Applicability With Indigenous Peoples And Communities, Tara Price, Tara Pride
The Open Journal of Occupational Therapy
Indigenous Peoples experience significant health inequities that must be understood in relation to historical and ongoing colonialism, racism, and discrimination. The occupational therapy profession has claimed commitment to addressing the Truth and Reconciliation Commission (TRC) calls to action, however, the profession is firmly grounded in Euro-Western epistemologies, including its assessments. The purpose of this paper was to assess the Canadian Occupational Performance Measure (COPM) for use with Indigenous clients and communities. Although the COPM uses flexibility through semi-structured interviews and the exclusion of standardized score comparisons, it is mired in colonial underpinnings and has hierarchical therapist-client power dynamics threaded throughout. …
Spirituality And Occupation In Living (Soil) Model: Conceptualizing Occupational Performance Through The Lens Of Spirituality, Clark Patrick Heard
Spirituality And Occupation In Living (Soil) Model: Conceptualizing Occupational Performance Through The Lens Of Spirituality, Clark Patrick Heard
The Open Journal of Occupational Therapy
Spirituality is a multi-faceted concept that includes varied personal, societal, and cultural informers. Despite a relatively high volume of analysis there is significant and ongoing debate about the concept of spirituality in occupational therapy. In particular, this discourse includes questions of relevance, how spirituality might be defined, and what its clinical application might entail.
To date, several models have connected spirituality with occupation but none have supported clinicians in framing occupational performance and occupational performance change in day-to-day clinical practice via a spirituality lens.
This paper describes the Spirituality and Occupation in Living (SOiL) model. This model is designed for …
Teaching Critical Reflection In Occupational Therapy: A Quantitative Pre/Post Evaluation Of Student Learning, Morgan Nelson, Lisa Jaegers, Quinn P. Tyminski, Niki Kiepek, Crystal Dieleman
Teaching Critical Reflection In Occupational Therapy: A Quantitative Pre/Post Evaluation Of Student Learning, Morgan Nelson, Lisa Jaegers, Quinn P. Tyminski, Niki Kiepek, Crystal Dieleman
The Open Journal of Occupational Therapy
This study was designed to answer the question, “Does student recognition of the assumptions underlying occupational therapy practice increase after participation in guided exercises of critical reflection?” The project is grounded in critical occupational therapy (as first named by Whiteford and Townsend) to promote students to reflect actively on dominant disciplinary ideologies and self-reflect on how one’s social positionality impacts understandings of occupational participation. The concept of non-sanctioned occupations was drawn on as a means to facilitate changes in student recognition. A one group, quantitative pre/post design with six open-ended responses was undertaken with master’s-level students (N = 53) at …
Sequential Simulations During Introductory Part-Time Fieldwork: Design, Implementation, And Student Satisfaction, Kaitlin R. Sibbald, Diane E. Mackenzie
Sequential Simulations During Introductory Part-Time Fieldwork: Design, Implementation, And Student Satisfaction, Kaitlin R. Sibbald, Diane E. Mackenzie
The Open Journal of Occupational Therapy
Background: Simulation is used in various ways in occupational therapy education and is recognized as a replacement for some conventional fieldwork hours. However, design and student satisfaction has had limited exploration.
Method: Sequential best practice simulations were designed for Level 1 fieldwork objectives in mental and musculoskeletal practice. The Satisfaction with Simulation Education scale (SSES) and qualitative feedback were used to assess student satisfaction. An exploratory factor analysis was used to validate the SSES in occupational therapy, and a three-factor repeated measures ANOVA was used to determine factors contributing to satisfaction across simulations.
Results: A three-factor model …
Occupational Therapy Curricula Patterns For Acquired Brain Injury-Related Vision Disorders For Entry-Level Programs: A Survey, Laura Schmeiser, Alicia Reiser, Caitlyn Foy
Occupational Therapy Curricula Patterns For Acquired Brain Injury-Related Vision Disorders For Entry-Level Programs: A Survey, Laura Schmeiser, Alicia Reiser, Caitlyn Foy
The Open Journal of Occupational Therapy
Occupational therapists are among the first providers to encounter individuals after an acquired brain injury (ABI). Evidence suggests that most occupational therapists learn about ABI-related vision disorders from continuing education and on-the-job training. A better understanding of entry-level curricula patterns for ABI-related vision disorders is important because of their high prevalence and impact on occupational performance. A descriptive online survey was administered to occupational therapy educators at ACOTE-accredited entry-level programs to explore curricula patterns for ABI-related vision disorders. Of 1,391 occupational therapy educators invited to participate, 71 (5%) began the survey, and 66 met the inclusion criteria. Vision screening methods …