Medicine and Health Sciences Commons^™

Keynote: Escaping A Code Stroke: Impact Of Escape Room Methodology On Nurses’ Attitudes Towards Acute Stroke Management Guidelines, Diana D. Tai

2023 South Division Nursing Research Conference

No abstract provided.

Poster: Eliminating Hospital Acquired Pressure Injuries (Hapis) In The Intensive Care Unit, Luzbel Diaz

2023 South Division Nursing Research Conference

No abstract provided.

Nursing Leadership Panel: Achieving Nurse Leader Respite Through Implementation Of A Nurse Leader Cross-Coverage Program, Kathryn Webster

2023 South Division Nursing Research Conference

No abstract provided.

Poster: Servant Leadership For Clinical Nurses, Stefanie Anderson, Tanya Hartley

2023 South Division Nursing Research Conference

No abstract provided.

Poster: Utilization Of Catheter Calendars For Cauti Reduction, Katie Whitehead

2023 South Division Nursing Research Conference

No abstract provided.

Poster: Nicu Reading Club: Promoting Early Reading In The Nicu, Hsiang-Fen Su, Irma Duke, Roxanne Arcinue

2023 South Division Nursing Research Conference

No abstract provided.

Nursing Panel Presentation: Improving Nurse Retention Through Group Mentoring, Sandra Orellana, Adriana Velez

2023 South Division Nursing Research Conference

No abstract provided.

Nursing Panel Presentation: Shared Governance & Transition Into Practice: Impact On Engagement, Gudrun Reiter-Hiltebran

2023 South Division Nursing Research Conference

No abstract provided.

Nursing Panel Presentation: Certification Champion Pilot Project To Increase Rn Specialty Certification Rates, Ari Meyers, Trisha Saul, Miriam Bender

2023 South Division Nursing Research Conference

No abstract provided.

Clinical Practice Panel: Improvements In Pediatric Food Insecurity Screening; A Qi Project To Increase Pediatric Food Insecurity Screening, Casey Katzman, Brandy Rachel Frye, Hsiang-Fen Su

2023 South Division Nursing Research Conference

No abstract provided.

Clinical Practice Panel: Stand By Me: Using An Enhanced Recovery After Surgery (Eras)Checklist To Guide Early Mobility Of Postoperative Craniotomy Patients On A Progressive Care Unit, Alyssa Mooney, Jerome Codilla, Joanna Arraiza, Sohl Chapman, Nkiru Chukwudi, Ronald Rosales

2023 South Division Nursing Research Conference

No abstract provided.

Poster: Clinical Practice Panel: Don't Skip A Beat, Follow The Sheet! Designing A Clinical Care Map For Open Heart Patients In The Icu, Danielle Fogel, Nico Vargas

2023 South Division Nursing Research Conference

No abstract provided.

Poster: Frontline Nurse Leader Satisfaction And Retention: Voices Of System Chief Nursing Executives, Giancarlo Lyle-Edrosolo, Marlon G Saria, Kenneth David Bailey

2023 South Division Nursing Research Conference

No abstract provided.

Nursing Leadership Panel: The Relationship Between Moral Injury, Moral Resilience, And The Healthy Work Environment Among Icu Nurses: Implications For Nurse Leaders, Sarah Sumner

2023 South Division Nursing Research Conference

No abstract provided.

The Effect Of A Psychologically Informed Video Series To Treat Adolescents' Patellofemoral Pain: A Randomized Controlled Trial., Mitchell Selhorst, Jessica Hoehn, Laura Schmitt, Jason Benedict, Alicia Fernandez-Fernandez

HPD Articles

OBJECTIVE: To test whether a series of brief, psychologically informed educational videos added to physical therapy improved function among adolescents with patellofemoral pain (PFP). The secondary aims were to assess pain and psychological beliefs.

DESIGN: A double-blinded randomized controlled trial.

METHODS: Sixty-eight adolescents with PFP were randomly assigned to view brief, psychologically-informed videos (n=34) or control videos (n=34) in addition to usual care physical therapy. The psychologically-informed videos targeted fear-avoidance beliefs, kinesiophobia, and pain catastrophizing. The control videos conveyed basic anatomy, biomedical factors, and lower extremity mechanics. Outcomes were assessed at baseline, three weeks, six weeks (primary endpoint), and three …

Poster: "Improving High Reliability Organization (Hro) Education, Culture, & Engagement Through Video ", Francis Khan, Alison Branson

Articles, Abstracts, and Reports

Background: While Providence began the HRO journey in 2015, the Northern California region didn’t launch until March 2022. While most leaders and caregivers have been trained, several still have difficulty remembering and applying the HRO principles and tools. The HRO Vlog provides a series of short videos that not only reinforce the various high reliability principles, but also provides real-life stories of caregivers who have successfully applied HRO principles and tools in their daily work. Purpose: According to Press Ganey’s Virtuous Cycle Model (Fig A.), safety and engagement the drivers of HRO. When safety and engagement operate in tandem, benefits …

Poster: Improving Emergency Department Belongings Inventory Electronic Medical Record Documentation, Shanekia Garrett, Stefanie Lai, Jairo Pagan, Wendy Lu, Katie Whitehead

Articles, Abstracts, and Reports

Improving Emergency Department Belongings Inventory Electronic Medical Record Documentation Rates Background: Electronic Medical Record (EMR) education and training for RNs should be multifaceted and targeted to the RN clinical workflow. Input from direct care RNs is essential to ensure EMR education is relevant and effective. Shared Governance at a community hospital identified quality and safety concerns among inpatient RNs. RNs reported that belongings inventories were not consistently documented in the EMR for Emergency Department (ED) admissions. Hospital policy requires belongings inventory EMR documentation for all admitted patients. An audit of charts for ED admissions over three months revealed only 5% …

Homeostatic Synaptic Plasticity Of Miniature Excitatory Postsynaptic Currents In Mouse Cortical Cultures Requires Neuronal Rab3a, Andrew G. Koesters, Mark M. Rich, Kathrin L. Engisch

Biological Sciences Faculty Publications

Following prolonged activity blockade, amplitudes of miniature excitatory postsynaptic currents (mEPSCs) increase, a form of homeostatic plasticity termed “synaptic scaling.” We previously showed that a presynaptic protein, the small GTPase Rab3A, is required for full expression of the increase in miniature endplate current amplitudes following prolonged blockade of action potential activity at the mouse neuromuscular junction in vivo (Wang et al., 2011), but it is unknown whether this form of Rab3A-dependent homeostatic plasticity shares any characteristics with central synapses. We show here that synaptic scaling of mEPSCs is impaired in mouse cortical neuron cultures prepared from Rab3A-/- and Rab3A Earlybird …

Developmental Approaches To Chronic Pain: A Narrative Review, Nikita P. Patel, Chad M. Bates, Aakash Patel

HPD Articles

Chronic pain, which can potentially develop from acute pain, subacute pain, or breakthrough pain, is generally defined as pain persisting for greater than three months with minimal relief. Chronic pain can be associated with a myriad of medical conditions. It is also one of the most common causes of disability, physical suffering, depression, and reduced quality of life. Treatment can vary depending on the underlying pathophysiology and can involve physical therapy, non-pharmaceutical approaches, pharmaceutical drugs, and invasive procedures. Currently available pharmaceutical agents have been effective for short-term management of chronic pain conditions, but few options address chronic pain with long-term …

The Lasting Effects Of Covid-19 On The Progression Of Metabolic Dysfunction-Associated Steatotic Liver Disease, Sean Backer, Deepesh Khanna

HPD Articles

It is estimated that around 30% of the population living in Western countries has metabolic dysfunctionassociated steatotic liver disease (MASLD), a spectrum of pathology (not attributed to alcohol/substance intake) initiated by steatosis and progression toward inflammation and irreversible fibrosis metabolic dysfunction-associated steatohepatitis (MASH). With inflammation being a key component of the transition to MASH, it raises the question of whether the ongoing COVID-19 pandemic, which has notoriously induced hyperinflammatory states, may influence the progression of MASLD. Specifically, it remains unclear if the potential chronic sequelae of COVID-19 in patients who recovered from it may increase the predisposition for MASH. Since …

Contraintes Thermophysiologiques Associées Aux Vêtements Individuels De Protection Des Pompiers : Impact Et Efficacité Des Membranes Barrières Et Des Designs Du Vêtement, Denis Marchand, Chantal Gauvin, Marie-Anne Landry-Duval

Rapports de recherche scientifique

Les vêtements individuels de protection (VIP) contribuent aux contraintes thermiques et physiologiques subies par les travailleurs. Or, ces contraintes constituent un problème préoccupant pour la santé et la sécurité, notamment pour les pompiers. D’ailleurs, les contraintes thermophysiologiques sont associées à un risque accru d’événements cardiovasculaires, qui représentent la cause la plus fréquente de décès chez les pompiers. L’objectif de cette étude était d’évaluer la réponse physiologique au port de VIP pour les pompiers, munis de deux membranes barrières humidifuges, dont l’une, ayant des propriétés de perméabilité à la vapeur d’eau et de transfert de chaleur améliorées. Un nouveau concept qui …

Association Between Lgb Status And Levels Of Mental Distress, Florida Brfss 2017-2019, Tammie M. Johnson, Torhonda Lee

Florida Public Health Review

Background: Poor mental health is a significant determinant of health in the US and is associated with several adverse health outcomes. Health-Related Quality of Life (HRQOL) measures help assess the mental distress burden on individuals and populations. This study examines mental distress health disparities at and above the frequent mental distress threshold among Florida adults who identify as lesbian, gay, or bisexual (LGB).

Methods: We used data from the 2017-2019 Florida Behavioral Risk Factor Surveillance System (BRFSS). A total of 39,876 adults aged 18 years and older were included in the analyses. The key dependent variables used for the study …

A Causal Inference Study: The Impact Of The Combined Administration Of Donepezil And Memantine On Decreasing Hospital And Emergency Department Visits Of Alzheimer’S Disease Patients, Ehsan Yaghmaei, Albert Pierce, Hongxia Lu, Yesha M. Patel, Louis Ehwerhemuepha, Ahmad Rezaie, Seyed Ahmad Sajjadi, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

Alzheimer’s disease is the most common type of dementia that currently affects over 6.5 million people in the U.S. Currently there is no cure and the existing drug therapies attempt to delay the mental decline and improve cognitive abilities. Two of the most commonly prescribed such drugs are Donepezil and Memantine. We formally tested and confirmed the presence of a beneficial drug-drug interaction of Donepezil and Memantine using a causal inference analysis. We applied doubly robust estimators to one of the largest and high-quality medical databases to estimate the effect of two commonly prescribed Alzheimer’s disease (AD) medications, Donepezil and …

Mettl14 Is A Chromatin Regulator Independent Of Its Rna N6-Methyladenosine Methyltransferase Activity, Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu

Faculty, Staff and Student Publications

METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of mouse embryonic stem cell (mESC). While comparable global hypo-methylation in RNA m6A was observed in Mettl3 or Mettl14 knockout mESCs, respectively. Mettl14 knockout led to a globally decreased nascent RNA synthesis, whereas Mettl3 depletion resulted in transcription upregulation, suggesting that METTL14 might possess an m6A-independent role in gene regulation. We found that METTL14 colocalizes with the repressive H3K27me3 modification. Mechanistically, METTL14, but not METTL3, binds …

Effect Of Resilience Training Program For Nurse Interns On Their Work Engagement, Yaldez K. Zein Eldin Prof, Ahmed Ragab Elwany Mr., Neamat Mohamed El Sayed Prof, Mayada Hassan El Zoheiry Dr

Nursing

Background: Resilience in nurses enables them to use positive adaptive skills in coping with stress and helps them keep up with the stressful environment of their work settings and it was proven that resilience was the most significant positive factor contributing to work engagement. It is difficult to accomplish high-quality patient care without nurse work engagement (WE), and in the current complex healthcare environment, the engagement of the nursing workforce is essential for delivering quality patient care and overcoming current challenges in healthcare. Objective: Determine the effect of resilience training program for nurse interns on their work engagement at their …

Genotype-By-Socioeconomic Status Interaction Influences Heart Disease Risk Scores And Carotid Artery Thickness In Mexican Americans: The Predominant Role Of Education In Comparison To Household Income And Socioeconomic Index, Vincent P. Diego, Eron G. Manusov, Xi Mao, Joanne E. Curran, Harald H. H. Goring, Marcio A. Almeida, Michael Mahaney, Juan M. Peralta, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Background: Socioeconomic status (SES) is a potent environmental determinant of health. To our knowledge, no assessment of genotype-environment interaction has been conducted to consider the joint effects of socioeconomic status and genetics on risk for cardiovascular disease (CVD). We analyzed Mexican American Family Studies (MAFS) data to evaluate the hypothesis that genotype-by-environment interaction (GxE) is an important determinant of variation in CVD risk factors.

Methods: We employed a linear mixed model to investigate GxE in Mexican American extended families. We studied two proxies for CVD [Pooled Cohort Equation Risk Scores/Framingham Risk Scores (FRS/PCRS) and carotid artery intima-media thickness (CA-IMT)] in …

Laparoscopic Repair Of Pediatric Femoral Hernias: A Scoping Review, Alex Chen, Spencer Wilhelm, Michael Sobolic, Begum Akay, Pavan Brahmamdam, Nathan Novotny

Conference Presentation Abstracts

No abstract provided.

Development Of A Sensitive Microplate Assay For Characterizing Rna Methyltransferase Activity: Implications For Epitranscriptomics And Drug Development, Isaiah K. Mensah, Allison B. Norvil, Ming He, Emma Lendy, Nicole Hjortland, Hern Tan, Richard T. Pomerantz, Andrew Mesecar, Humaira Gowher

Department of Biochemistry and Molecular Biology Faculty Papers

RNA methylation is a ubiquitous post-transcriptional modification found in diverse RNA classes and is a critical regulator of gene expression. In this study, we used Zika virus RNA methyltransferase (MTase) to develop a highly sensitive microplate assay that uses a biotinylated RNA substrate and radiolabeled AdoMet coenzyme. The assay is fast, highly reproducible, exhibits linear progress-curve kinetics under multiple turnover conditions, has high sensitivity in competitive inhibition assays, and significantly lower background levels compared with the currently used method. Using our newly developed microplate assay, we observed no significant difference in the catalytic constants of the full-length nonstructural protein 5 …

N-Terminal Α-Amino Sumoylation Of Cofilin-1 Is Critical For Its Regulation Of Actin Depolymerization, Weiji Weng, Xiaokun Gu, Yang Yang, Qiao Zhang, Qi Deng, Jie Zhou, Jinke Cheng, Michael X Zhu, Junfeng Feng, Ou Huang, Yong Li

Faculty, Staff and Student Publications

Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function. Cofilins are key regulators of actin cytoskeleton dynamics and are well-known to undergo several different PTMs. Here, we show that cofilin-1 is conjugated by SUMO1 both in vitro and in vivo. Using mass spectrometry and biochemical and genetic approaches, we identify the N-terminal α-amino group as the SUMO-conjugation site of cofilin-1. Common to conventional SUMOylation is that the N-α-SUMOylation of cofilin-1 is also mediated by SUMO activating (E1), conjugating (E2), …

Cardiovascular Disease And Stroke In Immune Ttp-Challenges And Opportunities, Senthil Sukumar, Marshall A Mazepa, Shruti Chaturvedi

Faculty, Staff and Students Publications

Advances in the management of immune thrombotic thrombocytopenic purpura (iTTP) have dramatically improved outcomes of acute TTP episodes, and TTP is now treated as a chronic, relapsing disorder. It is now recognized that iTTP survivors are at high risk for vascular disease, with stroke and myocardial infarction occurring at younger ages than in the general population, and cardiovascular disease is the leading cause of premature death in this population. iTTP appears to have a phenotype of accelerated vascular aging with a particular predilection for cerebral circulation, and stroke is much more common than myocardial infarction. In addition to traditional cardiovascular …