Medicine and Health Sciences Commons^™

Destigmatizing Complex Regional Pain Syndrome Through Art And Research, Jennifer K. Fortuna

The Open Journal of Occupational Therapy

Bill Dambrova, an artist based in Phoenix, AZ, provided the cover art for the Fall 2023 issue of the Open Journal of Occupational Therapy (OJOT). Bill’s paintings explore the intrinsic and extrinsic relationships between living things. Through the Artists + Researchers (ARx) program, Bill was teamed with Dr. Gretchen Bachman, OTD, OTR/L, MBA, CEAS, CHT, and Dr. Cindy Ivy, OTD, OTR/L, MEd, CHT, occupational therapy professors and researchers from Northern Arizona University. Their goal was to create a work of art that could disseminate research on complex regional pain syndrome (CRPS). The partnership led to the creation of “Invisible War,” …

Gender As Occupation: The "Doing" Of Authentic Expression And Reciprocally Affirming Care For Transgender Individuals, Annie Derolf, Johnna Belkiewitz, Sally Wasmuth

The Open Journal of Occupational Therapy

The current predominant view of gender as binary, alongside limited training of affirmative care practices, is severely and negatively impacting transgender and gender diverse (TGD) people. This paper urges the re-conceptualization of gender as an occupation, suggesting that gender is a doing that allows for positive identity development, roles, habits, and routines. Doing gender facilitates meaning-making and the ability to engage in other occupations. However, occupational injustices rooted in discrimination, stigma, and/or implicit biases impede TGD people’s ability to engage in the doing of gender and other occupations. Articulation of conceptual guidelines and interventions to support TGD people’s ability to …

Crawling Out From Under: A Physical Therapist’S Celebration Of The Power Of Occupational Therapy, Natalie N. Michaels

The Open Journal of Occupational Therapy

Isaacs’ syndrome, also known as Acquired Neuromyotonia, is a rare condition caused by continuous firing of the motor units, leading to twitching muscles and cramping that will persist even during sleep. The medical treatment of Isaacs’ syndrome is nondescript and arbitrary. Because of the rare incidence of the disorder, very few studies have been conducted to help determine the appropriate intervention for individuals with this affliction. This paper is a narrative case-study that offers a first-person account of a physical therapist with Isaacs’ syndrome and her journey through rehabilitation with her occupational therapist. The progress of this individual over time …

Aging In Place: Key Occupational Therapy Collaborators, Shivani B. Vij

The Open Journal of Occupational Therapy

No abstract provided.

A New Opportunity For Occupational Therapists To Open Cases In Home Health, Amy Oselio, Bryan M. Gee, Kimberly Lloyd

The Open Journal of Occupational Therapy

As of January 1, 2022, licensed occupational therapists have the permanent ability to open home health cases for the first time since 1999. This ability creates opportunities for occupational therapists to case-manage in the home health setting and showcase the benefits of occupation-based interventions for their clients. Further, occupation-based interventions create opportunities to establish aging-in-place and other cost-saving strategies. Occupational therapists will need to inform their home health agencies about this new ability, emphasizing the benefits of a more substantial presence in home health episodes of care. They will also need to develop new skills in the admission process or …

Use Of Formal And Informal Strategies To Manage Stress During Level Ii Occupational Therapy Fieldwork, Ryan Thomure

The Open Journal of Occupational Therapy

Stress may play a role in the performance of occupational therapy students during Level II fieldwork, but little research exists regarding the causes of stress or the stress management strategies students use. The objective of this study was to determine factors that contribute to fieldwork-related stress and strategies students use to manage that stress on Level II fieldwork.

Students or recent graduates of occupational therapy or occupational therapy assistant programs who completed at least one Level II fieldwork experience in the previous 36 months were eligible to participate. An online survey was distributed to participants through snowball sampling. The participants …

Application Of A Model Of Family-Centered Harm Reduction In Community-Based Programming, Johnna Belkiewitz, Victoria G. Wilburn, Sydney Larson, Kate Schrader

The Open Journal of Occupational Therapy

Coupling high substance use disorder rates with the effects of the COVID-19 pandemic, our nation faces a growing mental health crisis and a shortage of adequately trained mental and behavioral health providers. As occupational therapists work toward recognition as qualified providers in this practice area, we must ensure that future therapists can meet client needs. Traditional mental and behavioral health educational practices in occupational therapy use a model of harm reduction that minimizes negative outcomes for a select subset of the population engaging in specific “high-risk” behaviors, such as individuals engaging in substance use and sexual activity. Expanding our understanding …

Intraprofessional Conversations Begin In The Classroom: An Exploratory Study Of An Occupational Therapist And Occupational Therapy Assistant Joint Class, Patricia Gentile, Michele Mills, Tsu-Hsin Howe

The Open Journal of Occupational Therapy

Effective occupational therapist and occupational therapy assistant partnerships are essential for the provision of quality patient care and satisfactory intraprofessional working relationships. Providing OT and OTA students with collaborative educational experiences can enhance students’ understanding and appreciation of each other’s roles, as well as set the groundwork for successful future work experiences.

This project describes the experience of a graduate OT master’s degree program and an associate degree OTA program in a northeastern metropolitan city. Faculty from both programs worked together to design and implement a collaborative learning experience during the Covid-19 pandemic, conducted via Zoom.

The purpose of this …

Addressing The Long-Term Influence Of Neurotrauma On Self-Concept And Self-Identity Development: A Pilot Study, Alyse C. Giallorenzo, Brittany C. Adams, Jessica M. Winter

The Open Journal of Occupational Therapy

Background: Numerous neurotrauma survivors face lifelong disability post injury as a result of an event, yet there are limited specialized continued care services to support future outcomes, specifically self-concept, self-identity, and quality of life. To reduce health care barriers and support health promotion post injury, student researchers explored the influence of a community-based occupational therapy (OT) program for the neurotrauma population.

Methods: Four participants, 37 to 58 years of age, with a history of neurotrauma, participated in a mixed methods study composed of a 6-week community-based educational OT program. Outcome measures included Activity Card Sort, Lawton Brody Scale, …

Physicians' Knowledge And Perceptions Of Occupational Therapy Practice, Shivani B. Vij

The Open Journal of Occupational Therapy

Background: Occupational therapy (OT) is a client-centered profession vital to an interdisciplinary team. Despite its importance, medical providers have limited knowledge and understanding of OT's scope of practice. This can lead to limited referrals, ineffective teamwork, inefficient therapeutic outcomes, limited OT practice scope, and consumer access to OT services. This study explored physicians' knowledge and understanding of OT to find opportunities and strategies for education and knowledge sharing to improve awareness of OT practice and interdisciplinary collaboration.

Method: A descriptive online survey was conducted for physicians in a Virginia suburban hospital to obtain knowledge and perception about OT …

Exploration Of Occupational Therapy Practice For Children With Autism Spectrum Disorders In The Dominican Republic, Katherine Lally, Michelle Messer, Vanessa D. Jewell

The Open Journal of Occupational Therapy

Background: To better understand the current practice trends of ASD treatment globally and promote practitioner collaboration, it is important to complete studies in countries where little is known about the diagnosis and treatment of ASD through an occupational lens. The aim of this study was to gain an insight into how occupational therapists in the Dominican Republic evaluate and treat children diagnosed with ASD.

Method: This qualitative descriptive study explored the perception of occupational therapists (n = 6) and caregivers of children with ASD (n = 28) through a questionnaire and focus group. Interview transcripts and questionnaire text …

Connected Rhythm: A Scoping Review Of Therapeutic Drumming As An Intervention For Autistic Individuals, Zahava L. Friedman, Jorge Ochoa, Dina Prisco, Francine M. Seruya

The Open Journal of Occupational Therapy

Background: Autism Spectrum Disorder (ASD) is a neurologically-based developmental disorder representing a subdomain of neurodivergence. Occupational therapy intervention for ASD typically incorporates sensory modalities, addressing a multitude of challenges, including mental health outcomes. This scoping review analyzes available evidence of the sensory-based intervention of therapeutic drumming (TD) to improve mental health in autistic clients.

Method: Following the Johanna Briggs methodological framework, Proquest, Ebsco, Scopus and OTseeker databases were searched with the key and related words of “autism,” “therapeutic drumming,” and “mental health,” yielding 448 articles. After removal of duplicates and application of inclusion criteria, seventeen articles were included …

Exploring The Use Of Ecological Momentary Assessment Within A Telehealth Intervention For Families Of Children With Autism, Anna Wallisch, Lauren Little, Allison Wainer, Winnie Dunn

The Open Journal of Occupational Therapy

Background. The purpose of this study was to explore the use of ecological momentary assessment (EMA) to measure parent self-efficacy and stress throughout a 9-week occupation-based coaching telehealth intervention for families of children with autism spectrum disorders (ASD).

Methods. The participants included seven families of children with ASD 2 to 6 years of age. The parents were sent emails to gather EMA measures weekly during the intervention. We used percentages to examine response rates to EMA surveys and a mixed-model regression to examine changes in parent-self efficacy and stress during the intervention.

Results. The parents responded to …

Establishing Initial Content Validity, Interrater Reliability, And Intra-Rater Reliability Of The Revised Visual Activity Sort For At-Risk Adolescents And Young Adults, Sharon Gutman, Katie O'Day, Ashley Choi, Alexis Kearney, Sandra Rogers

The Open Journal of Occupational Therapy

Background: The purpose of this study was to establish the content validity and inter- and intra-rater reliability of the revised Visual Activity Sort, which is a card sorting assessment designed specifically for at-risk adolescents and young adults.

Method: Six content experts were selected and asked to rate the relevancy of each of the 121 Visual Activity Sort cards. Two trained raters participated in the establishment of inter- and intra-rater reliability with 30 high school students attending a charter school for at-risk adolescents and young adults in a socioeconomically disadvantaged urban area.

Results: Based on the content experts’ …

Providing Personalized Interest-Based Activities To Prevent Delirium: A Multicomponent Quality Improvement Initiative In An Acute Care Setting, Qianwen Liu, Elena V. Donoso Brown, Shauni Johnson, Autumn Moss-Corcoran

The Open Journal of Occupational Therapy

Background: Hospital-induced delirium is a prevalent condition across inpatient settings, frequently impacting older adults’ recovery. A 10-week multi-component quality improvement (QI) project was designed for an existing delirium prevention program in four acute care units, aiming to support patient and caregiver engagement in delirium prevention activities.

Method: The participants were hospitalized adults who were 70 years of age and older and met specific inclusion criteria. The project provided personalized interest-based activities, orientation stimulation, and caregiver education. An abbreviated version of the Modified Interest Checklist was used to identify the participants’ activity choices. Activity daily logs, satisfaction survey, and …

Thermoplastic Material Selection And Barriers To Custom Orthotic Fabrication: A Survey Of Occupational And Physical Therapists, Priya Bakshi, Daisy Castillo, Heidi Mitchener, Zoee Lagerhausen, Lauren Paisley, Amanda Quinlivan, Brandi Andreae

The Open Journal of Occupational Therapy

Background: There is limited literature regarding therapists’ selection of thermoplastic material since the 1990s and less is known about the challenges of custom orthotic fabrication.

Methods: A cross-sectional survey was designed and distributed to members of the American Society of Hand Therapists in August 2021. The survey included closed-ended questions with option for free-text comments. Descriptive statistics and content analysis was used to analyze categorical data and free-text comments, respectively.

Results: The responses of 333 therapists were included in the study. Drapability, thickness, and rigidity were the main properties the therapists considered when selecting thermoplastic material (82.9%; …

Examining The Delivery Mode Of Mental Practice In Reducing Hemiparesis: A Randomized Controlled Trial, Teresa M. Green, Nicole M. Fromm, Farida Sita Gayle, Jinna Lee, Wanyi Wang, Asha K. Vas

The Open Journal of Occupational Therapy

Background: Mental Practice (MP) is an effective intervention to address upper extremity (UE) hemiparesis post-stroke. However, parameters for the delivery mode of MP have not been defined. Therefore, this study's purpose was to define delivery mode parameters by comparing the effectiveness of audio-guided and video-guided MP.

Method: Eighteen participants, < 1-month post-stroke, with UE hemiparesis were randomized to a MP, repetitive task practice (RTP) or control group. The MP groups performed audio-guided or video-guided MP, 5x/week. The RTP group physically performed the functional tasks. The control group received traditional stroke rehabilitation. The Fugl-Meyer Assessment (FMA-UE) and Wolf Motor Function Test (WMFT) were used to assess change in UE hemiparesis.

Results: Wilcoxon signed-rank test demonstrated audio MP increased FMA-UE scores from pretest (Mdn = 34.0, Mean = 34.0, SD =9.56) to posttest (Mdn = 49.0, Mean = 49.6, SD =7.5), p = .042, r = .64. Similar improvement in FMA-UE scores was found with traditional therapy. Audio MP decreased WMFT …

Occupational Therapist And Occupational Therapy Assistant: We Are Proud Of These Titles, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Interruption Of The Tricuspid Regurgitant Jet: A Possible Consequence Of Reflected Waves, Saad Ngoga, Nicole Schulick, J. Christopher Bouwmeester, Jiun-Jr Wang, Gregg S. Pressman

Einstein Health Papers

Reflected pressure waves can impact central aortic pressure, and can cause notching of the pulmonic valve Doppler signal. However, reflected waves in the venous system usually do not achieve a high enough velocity to alter Doppler flow patterns. Herein we report a case of systolic notching of the tricuspid regurgitant signal that likely resulted from reflected venous waves.

A Single-Dose Intramuscular Immunization Of Pigs With Lipid Nanoparticle Dna Vaccines Based On The Hemagglutinin Antigen Confers Complete Protection Against Challenge Infection With The Homologous Influenza Virus Strain, The N. Nguyen, Sushmita Kumari, Sarah Vitosh-Sillman, Jayeshbhai Chaudhari, Danh C. Lai, Hiep Vu

Nebraska Center for Virology: Faculty Publications

The Influenza A virus of swine (IAV-S) is highly prevalent and causes significant economic losses to swine producers. Due to the highly variable and rapidly evolving nature of the virus, it is critical to develop a safe and versatile vaccine platform that allows for frequent updates of the vaccine immunogens to cope with the emergence of new viral strains. The main objective of this study was to assess the feasibility of using lipid nanoparticles (LNPs) as nanocarriers for delivering DNA plasmid encoding the viral hemagglutinin (HA) gene in pigs. The intramuscular administration of a single dose of the LNP-DNA vaccines …

Investigating Associations Of Omega-3 Fatty Acids, Lung Function Decline, And Airway Obstruction, Bonnie K Patchen, Pallavi Balte, Traci M Bartz, R Graham Barr, Myriam Fornage, Mariaelisa Graff, David R Jacobs, Ravi Kalhan, Rozenn N Lemaitre, George O'Connor, Bruce Psaty, Jungkyun Seo, Michael Y Tsai, Alexis C Wood, Hanfei Xu, Jingwen Zhang, Sina A Gharib, Ani Manichaikul, Kari North, Lyn M Steffen, Josée Dupuis, Elizabeth Oelsner, Dana B Hancock, Patricia A Cassano

Faculty, Staff and Student Publications

Rationale: Inflammation contributes to lung function decline and the development of chronic obstructive pulmonary disease. Omega-3 fatty acids have antiinflammatory properties and may benefit lung health.

Objectives: To investigate associations of omega-3 fatty acids with lung function decline and incident airway obstruction in a diverse sample of adults from general-population cohorts.

Methods: Complementary study designs: 1) longitudinal study of plasma phospholipid omega-3 fatty acids and repeated FEV1 and FVC measures in the NHLBI Pooled Cohorts Study and 2) two-sample Mendelian randomization (MR) study of genetically predicted omega-3 fatty acids and lung function parameters.

Measurements and Main Results: The …

Deep Learning Analysis Of Uplc-Ms/Ms-Based Metabolomics Data To Predict Alzheimer's Disease, Kesheng Wang, Laurie A. Theeke, Christopher Liao, Nianyang Wang, Yongke Lu, Danqing Xiao, Chun Xu

Health & Biomedical Sciences Faculty Publications

Objective

Metabolic biomarkers can potentially inform disease progression in Alzheimer's disease (AD). The purpose of this study is to identify and describe a new set of diagnostic biomarkers for developing deep learning (DL) tools to predict AD using Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS/MS)-based metabolomicsdata.

Methods

A total of 177 individuals, including 78 with AD and 99 with cognitive normal (CN), were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort along with 150 metabolomic biomarkers. We performed feature selection using the Least Absolute Shrinkage and Selection Operator (LASSO). The H2O DL function was used to build multilayer …

Possible Delayed Foreign Body Reactions Against Titanium Clips And Coating Materials After Unruptured Cerebral Aneurysm Surgery, Ryota Tatezawa, Taku Sugiyama, Shuho Gotoh, Takafumi Shindo, Hiroshi Ikeda, Masaaki Hokari, Katsumi Takizawa, Naoki Nakayama, Miki Fujimura

Faculty, Staff and Student Publications

Delayed foreign body reactions to either or both clipping and coating materials have been reported in several small series; however, studies in the titanium clip era are scarce. This study aims to survey the contemporary status of such reactions to titanium clips and coating materials. Among patients who received a total of 2327 unruptured cerebral aneurysmal surgeries, 12 developed delayed intraparenchymal reactions during outpatient magnetic resonance imaging (MRI) follow-up. A retrospective investigation was conducted. The patients' average age was 58.6 (45-73) years, and 11 were women. The aneurysms were located in the middle cerebral artery (n = 7), internal carotid …

Associations Between Birth Defects And Childhood And Adolescent Germ Cell Tumors According To Sex, Histologic Subtype, And Site, Jeremy M Schraw, Pagna Sok, Tania A Desrosiers, Amanda E Janitz, Peter H Langlois, Mark A Canfield, A Lindsay Frazier, Sharon E Plon, Philip J Lupo, Jenny N Poynter

Faculty, Staff and Students Publications

BACKGROUND: Studies have reported increased rates of birth defects among children with germ cell tumors (GCTs). However, few studies have evaluated associations by sex, type of defect, or tumor characteristics.

METHODS: Birth defect-GCT associations were evaluated among pediatric patients (N = 552) with GCTs enrolled in the Germ Cell Tumor Epidemiology Study and population-based controls (N = 6380) without cancer from the Genetic Overlap Between Anomalies and Cancer in Kids Study. The odds ratio (OR) and 95% confidence interval (CI) of GCTs according to birth defects status were estimated by using unconditional logistic regression. All defects were considered collectively and …

Stroke Recovery Is A Journey: Prediction And Potentials Of Motor Recovery After A Stroke From A Practical Perspective, Sheng Li

Faculty, Staff and Student Publications

Stroke recovery is a journey. Stroke survivors can face many consequences that may last the rest of their lives. Assessment of initial impairments allows reasonable prediction of biological spontaneous recovery at 3 to 6 months for a majority of survivors. In real-world clinical practice, stroke survivors continue to improve their motor function beyond the spontaneous recovery period, but management plans for maximal recovery are not well understood. A model within the international classification of functioning (ICF) theoretical framework is proposed to systematically identify opportunities and potential barriers to maximize and realize the potentials of functional recovery from the acute to …

Endothelial Dysfunction And Cardiometabolic Risk Factors In Mexican American Adults: The Cameron County Hispanic Cohort, Enrique Garcia-Sayan, Miryoung Lee, James R Stone, Danielle M Stone, Beverly Smulevitz, David D Mcpherson, Susan P Fisher-Hoch, Joseph B Mccormick, Susan T Laing

Faculty, Staff and Students Publications

Endothelial dysfunction assessed by impaired brachial flow-mediated dilation (FMD) predicts incident cardiovascular disease (CVD). We have previously shown that clustering of diabetes mellitus, obesity, and metabolic syndrome in young Hispanic patients was associated with subclinical atherosclerosis. This study aimed to assess determinants of impaired FMD response (%FMD), an earlier marker of atherosclerosis, in a population-based sample of asymptomatic Mexican Americans. Cardiometabolic biomarkers and FMD were obtained from 960 Cameron County Hispanic Cohort participants. Gender-specific median values of %FMD were used to categorize participants into those with %FMD below or above the median. The sample was further stratified into those younger …

Time- And Region-Dependent Blood-Brain Barrier Impairment In A Rat Model Of Organophosphate-Induced Status Epilepticus, Pedro N Bernardino, Brad A Hobson, Sydney L Huddleston, Peter M Andrew, Jeremy A Macmahon, Naomi H Saito, Valerie A Porter, Donald A Bruun, Danielle J Harvey, Joel R Garbow, Angie Gelli, Abhijit J Chaudhari, Pamela J Lein

2020-Current year OA Pubs

Acute organophosphate (OP) intoxication can trigger seizures that progress to status epilepticus (SE), and survivors often develop chronic morbidities, including spontaneous recurrent seizures (SRS). The pathogenic mechanisms underlying OP-induced SRS are unknown, but increased BBB permeability is hypothesized to be involved. Previous studies reported BBB leakage following OP-induced SE, but key information regarding time and regional distribution of BBB impairment during the epileptogenic period is missing. To address this data gap, we characterized the spatiotemporal progression of BBB impairment during the first week post-exposure in a rat model of diisopropylfluorophosphate-induced SE, using MRI and albumin immunohistochemistry. Increased BBB permeability, which …

Manf Stimulates Autophagy And Restores Mitochondrial Homeostasis To Treat Autosomal Dominant Tubulointerstitial Kidney Disease In Mice, Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Terri A Pietka, Jothilingam Sivapackiam, Sun-Ji Park, Fumihiko Urano, Vijay Sharma, Ying Maggie Chen, Et Al.

2020-Current year OA Pubs

Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary kidney disease. There are no targeted therapies. In our generated mouse model recapitulating human ADTKD-UMOD carrying a leading UMOD mutation, we show that autophagy/mitophagy and mitochondrial biogenesis are impaired, leading to cGAS-STING activation and tubular injury. Moreover, we demonstrate that inducible tubular overexpression of mesencephalic astrocyte-derived neurotrophic factor (MANF), a secreted endoplasmic reticulum protein, after the onset of disease stimulates autophagy/mitophagy, clears mutant UMOD, and promotes mitochondrial biogenesis through p-AMPK enhancement, thus protecting kidney function in our ADTKD mouse …

Ca2+-Regulated Expression Of High Affinity Methylaminoisobutryic Acid Transport In Hippocampal Neurons Inhibited By Riluzole And Novel Neuroprotective Aminothiazoles, Jeffrey D. Erickson, Thomas Kyllo, Heike Wulff

School of Medicine Faculty Publications

High affinity methylaminoisobutyric acid(MeAIB)/glutamine(Gln) transport activity regulated by neuronal firing occurs at the plasma membrane in mature rat hippocampal neuron-enriched cultures. Spontaneous Ca2+-regulated transport activity was similarly inhibited by riluzole, a benzothiazole anticonvulsant agent, and by novel naphthalenyl substituted aminothiazole derivatives such as SKA-378. Here, we report that spontaneous transport activity is stimulated by 4-aminopyridine (4-AP) and that phorbol-myristate acetate (PMA) increases high K+ stimulated transport activity that is inhibited by staurosporine. 4-AP-stimulated spontaneous and PMA-stimulated high K+-induced transport is not present at 7 days in vitro (DIV) and is maximal by DIV∼21. The relative affinity for MeAIB is similar …

Computed Tomography Attenuation Of Three-Dimensional (3d) Printing Materials-Depository To Aid In Constructing 3d-Printed Phantoms, Yuktesh Kalidindi, Aravinda Krishna Ganapathy, Yash Nayak, Anusha Elumalai, David Z Chen, Grace Bishop, Adrian Sanchez, Brian Albers, Anup S Shetty, David H Ballard

2020-Current year OA Pubs

Three-dimensionally printed phantoms are increasingly used in medical imaging and research due to their cost-effectiveness and customizability, offering valuable alternatives to commercial phantoms. The purpose of this study was to assess the computed tomography (CT) attenuation characteristics of 27 resin materials from Formlabs, a 3D printing equipment and materials manufacturer. Cube phantoms (both solid and hollow constructions) produced with each resin were subjected to CT scanning under varying tube current-time products with attenuation measurements recorded in Hounsfield units (HU). The resins exhibited a wide range of attenuation values (-3.33 to 2666.27 HU), closely mimicking a range of human tissues, from …