Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (76822)
- Public Health (55588)
- Medical Sciences (45068)
- Life Sciences (42040)
- Nursing (34101)
-
- Social and Behavioral Sciences (33576)
- Diseases (21708)
- Education (19664)
- Rehabilitation and Therapy (16580)
- Mental and Social Health (14465)
- Medical Education (14364)
- Oncology (14280)
- Arts and Humanities (13182)
- Dentistry (13135)
- Physical Sciences and Mathematics (11055)
- Veterinary Medicine (9758)
- Psychiatry and Psychology (9549)
- Pharmacy and Pharmaceutical Sciences (9488)
- Sports Sciences (9122)
- Pediatrics (9018)
- Health and Medical Administration (8946)
- Biomedical Informatics (8880)
- Psychology (8274)
- Sociology (8016)
- Public Health Education and Promotion (7971)
- Bioinformatics (7874)
- Medical Genetics (6997)
- Business (6892)
- Occupational Therapy (6818)
- Institution
-
- The Texas Medical Center Library (25568)
- Thomas Jefferson University (14879)
- Chulalongkorn University (11387)
- Washington University School of Medicine (10401)
- Aga Khan University (9505)
-
- University of Kentucky (8642)
- TÜBİTAK (8080)
- Walden University (6102)
- Western Michigan University (5794)
- Virginia Commonwealth University (5384)
- University of Nebraska - Lincoln (5204)
- Edith Cowan University (4970)
- Western Kentucky University (4358)
- American Dental Association (4285)
- Lehigh Valley Health Network (4082)
- University of Texas Rio Grande Valley (4016)
- Nova Southeastern University (3998)
- Himmelfarb Health Sciences Library, The George Washington University (3649)
- Universitas Indonesia (3628)
- University of Nebraska Medical Center (3616)
- Old Dominion University (3431)
- University of Nevada, Las Vegas (3347)
- Marquette University (3242)
- University of Alabama at Birmingham (3145)
- University of South Carolina (3144)
- Children's Mercy Kansas City (2987)
- Wright State University (2933)
- HCA Healthcare (2908)
- Western University (2904)
- University of North Dakota (2887)
- Keyword
-
- Humans (25578)
- Female (11801)
- Male (10437)
- Animals (7742)
- COVID-19 (7413)
-
- Adult (6146)
- Middle Aged (5182)
- Mice (5121)
- ICTS (Institute of Clinical and Translational Sciences) (5019)
- Aged (4657)
- Child (3543)
- Adolescent (3079)
- United States (2904)
- Michigan (2883)
- Nursing (2616)
- Education (2572)
- Obesity (2489)
- Mental health (2412)
- Depression (2355)
- Public health (2298)
- English (2266)
- Retrospective Studies (2258)
- Pregnancy (2198)
- Cancer (2183)
- Thomas Jefferson University (2032)
- Children (1995)
- Treatment Outcome (1897)
- Young Adult (1813)
- Infant (1759)
- Occupational therapy (1686)
- Publication Year
-
- 2026 (14588)
- 2025 (24442)
- 2024 (27126)
- 2023 (27418)
- 2022 (23764)
-
- 2021 (21379)
- 2020 (20658)
- 2019 (16113)
- 2018 (15422)
- 2017 (14527)
- 2016 (12710)
- 2015 (11980)
- 2014 (9579)
- 2013 (7930)
- 2012 (7308)
- 2011 (6767)
- 2010 (5685)
- 2009 (4375)
- 2008 (3694)
- 2007 (3121)
- 2006 (2765)
- 2005 (2796)
- 2004 (2219)
- 2003 (1917)
- 2002 (1799)
- 2001 (1650)
- 2000 (1581)
- 1999 (1656)
- 1998 (1486)
- 1997 (1145)
- Publication
-
- Faculty, Staff and Student Publications (13660)
- Faculty, Staff and Students Publications (7681)
- 2020-Current year OA Pubs (7255)
- Walden Dissertations and Doctoral Studies (5856)
- Turkish Journal of Medical Sciences (4871)
-
- Theses and Dissertations (4192)
- Chulalongkorn Medical Journal (4154)
- Turkish Journal of Veterinary & Animal Sciences (3209)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (3086)
- International Journal of Exercise Science: Conference Proceedings (2674)
- All ETDs from UAB (2525)
- The Thai Journal of Veterinary Medicine (2524)
- Journal Articles (2396)
- Faculty Publications (2315)
- Research outputs 2022 to 2026 (2296)
- Electronic Theses and Dissertations (2232)
- Henry Ford Hospital Medical Journal (2151)
- Dissertations (1925)
- Loma Linda University Electronic Theses, Dissertations & Projects (1807)
- School of Medicine Publications (1695)
- Doctor of Nursing Practice Projects (1541)
- What's Happening (1535)
- Research outputs 2014 to 2021 (1525)
- Publications and Research (1504)
- Masters Theses (1502)
- Manuscripts, Articles, Book Chapters and Other Papers (1458)
- Dissertations and Theses (Open Access) (1411)
- Dartmouth Scholarship (1400)
- Reproductive Health (1317)
- Rehabilitation Practice and Science (1275)
- Publication Type
Articles 6751 - 6780 of 324827
Full-Text Articles in Medicine and Health Sciences
West Alabama General Hospital Scholarship Letter, Kathryn Hicks
West Alabama General Hospital Scholarship Letter, Kathryn Hicks
Correspondence
Scholarship letter issued by the Virginia Planz Memorial Nursing Scholarship Committee of West Alabama General Hospital to University of North Alabama nursing student Barbara Montgomery.
St. Thomas Hospital Scholarship Letter, Peter J. Giammalvo
St. Thomas Hospital Scholarship Letter, Peter J. Giammalvo
Correspondence
Letter from the St. Thomas Foundation Scholarship Committee to University of North Alabama nursing student Barabara Jean Montgomery detailing a grant in the amount of $1,200 contingent upon her employment at St. Thomas Hospital for one year following graduation.
Pulling The Plug: Alabama's Natural Death Act, A Free Symposium In Five Perspectives -- Law, Religion, Medicine, Nursing, Humanities, The Committee For The Humanities In Alabama, National Endowment For The Humanities, Health Education & Action League
Pulling The Plug: Alabama's Natural Death Act, A Free Symposium In Five Perspectives -- Law, Religion, Medicine, Nursing, Humanities, The Committee For The Humanities In Alabama, National Endowment For The Humanities, Health Education & Action League
Documents
The program for Pulling the Plug: Alabama's Natural Death Act, a free symposium in five perspectives -- law, religion, medicine, nursing, humanities held in Huntsville, Alabama on May 20, 1982 mentions critical discussions on Alabama's Natural Death Act, the dignity of terminally ill and suffering patients, medical technology, and the impact of ethical and religious conviction.
Memorandum & Fact Sheet: Una Student Nurses' Association, The Dean And Faculty Of The Una School Of Nursing
Memorandum & Fact Sheet: Una Student Nurses' Association, The Dean And Faculty Of The Una School Of Nursing
Correspondence
Memorandum and fact sheet issued from the dean and faculty of the University of North Alabama school of Nursing to nursing majors concerning the Student Nurses' Association. The document details information about the benefits of joining the organization and various facts.
Student Nurses Association Awardees (1980-1981), Student Nurses' Association (Sna)
Student Nurses Association Awardees (1980-1981), Student Nurses' Association (Sna)
Documents
List of awardees selected by the Student Nurses' Association (SNA) in the 1980-1981 academic year for outstanding service and academic performance within the School of Nursing at the University of North Alabama
Memorandum: Proposed Nursing Program At The University Of North Alabama, John F. Porter Jr., Ache (Alabama Commission On Higher Education) Staff
Memorandum: Proposed Nursing Program At The University Of North Alabama, John F. Porter Jr., Ache (Alabama Commission On Higher Education) Staff
Correspondence
Annotated memorandums concerning the subcommittee on the proposed nursing program at the University of Alabama. The first memorandum was issued to the Council of University Presidents from John F. Porter Jr., Executive Director of the Alabama State Commission of Higher Education. Whereas the second was issued by the ACHE Staff to Members of the Alabama Commission on Higher Education.
'Access To Life' Begins Workshops, Kandis Steele
'Access To Life' Begins Workshops, Kandis Steele
Documents
In the article, Dr. Ernestine Davis of the UNA School of Nursing addresses the concerns of the elderly through a workshop sponsored by the Southern Rural Health Care Consortium's Access to Life Program and the Home Extension office. The news article is derived from the Franklin County Times of Franklin County, Alabama.
Student Nurses Association Spring Awards Banquet, Program, University Of North Alabama, School Of Nursing
Student Nurses Association Spring Awards Banquet, Program, University Of North Alabama, School Of Nursing
Documents
Program for the 1985 Spring Awards banquet of the University of North Alabama's Student Nurses' Association (SNA)
National League For Nursing: Certificates Of Membership, National League For Nursing, The Council Of Baccalaureate And Higher Degree Programs
National League For Nursing: Certificates Of Membership, National League For Nursing, The Council Of Baccalaureate And Higher Degree Programs
Documents
Certificates of membership in the National League of Nursing issued to Florence State University and the University of North Alabama's School of Nursing for December 31 of 1974-76 and 1978 by the National League for Nursing and the Council of Baccalaureate and Higher Degree Programs
Daddies At Graduation And A Nurse In Uniform, William L. Mcdonald
Daddies At Graduation And A Nurse In Uniform, William L. Mcdonald
Documents
The first article, "Daddies at Graduation" (1978), addresses the bittersweet experiences of local historian William Lindsey McDonald, while attending the graduation of his oldest daughter, Nancy McDonald Buttram, from the School of Nursing at the University of North Alabama.
The second article, "A Nurse in Uniform," (1979), features McDonald's reflection on his daughter's career in nursing.
Una School Of Nursing Pinning Ceremony, Program (Dec. 15, 1985), University Of North Alabama, School Of Nursing
Una School Of Nursing Pinning Ceremony, Program (Dec. 15, 1985), University Of North Alabama, School Of Nursing
Documents
Program for the Fall 1985 Pining Ceremony for the University of North Alabama's School of Nursing
Dens Invaginatus Prevalence In Maxillary Lateral Incisors In Egyptian Population: Cone Beam Computed Tomography 3-Dimensional Analysis, Marwa Ezz, Sherif Heidar, Mahinaz Reda Abdelhamed
Dens Invaginatus Prevalence In Maxillary Lateral Incisors In Egyptian Population: Cone Beam Computed Tomography 3-Dimensional Analysis, Marwa Ezz, Sherif Heidar, Mahinaz Reda Abdelhamed
Dentistry
Introduction: Dens invaginatus also called dens in dente is frequent developmental anomaly, most commonly affect maxillary lateral incisors. It can create an inflammatory and microbial pathway that may compromise pulp vitality. Once detected, intervention must be planned. Aim of the study : This study investigated Dens invaginatus prevalence in maxillary lateral incisors in Egyptian population and its categorization according to Oehlers classification using CBCT. Materials and Methods This study assessed 296 cone beam computed tomography scans including a total number of 592 maxillary lateral incisor. Two experienced examiners: an oral and maxillofacial radiologist and an endodontist, inspected Dens invaginatus in …
Patient Perceptions Of Empathy In Medical Student Encounters: Comparing Electronic And Handwritten Notetaking Methods, Harish Karthikeyan, Asad H. Siddiqui, Stacey Algren, Angellar Manguvo
Patient Perceptions Of Empathy In Medical Student Encounters: Comparing Electronic And Handwritten Notetaking Methods, Harish Karthikeyan, Asad H. Siddiqui, Stacey Algren, Angellar Manguvo
Innovations in Health Sciences Education Journal
Objectives: Patient interviews are central to clinical practice, serving as both an information-gathering tool and a foundation for rapport and empathy. With the increased use of electronic documentation during clinic visits, concerns have been raised about technology detracting from the patient-clinician connection. This study examined whether medical students’ notetaking modality (electronic vs handwritten) influenced patient perceptions of empathy during clinical encounters.
Study Design: This study employed a causal-comparative approach, as student groups occurred naturally, combined with a survey design to collect data from patients.
Methods: A total of 135 student–patient encounters were analyzed at the University of Missouri–Kansas City School …
Mindset Transformation In School Counseling Services After The Training Program 7 Jurus Bk Hebat: A Mixed Method Study, Mulawarman Mulawarman, Farida Aryani, Aldila Dyas Nurfitri, Najma Sana Nadhirah Hilman, Galuh Nadhita, Erna Dwi Nugraini, Abi Fa’Izzarahman Prabawa, Eni Rindi Antika
Mindset Transformation In School Counseling Services After The Training Program 7 Jurus Bk Hebat: A Mixed Method Study, Mulawarman Mulawarman, Farida Aryani, Aldila Dyas Nurfitri, Najma Sana Nadhirah Hilman, Galuh Nadhita, Erna Dwi Nugraini, Abi Fa’Izzarahman Prabawa, Eni Rindi Antika
Jurnal Kajian Bimbingan dan Konseling
School counseling services have shifted from a remedial approach to one of development and prevention, requiring school counselors to possess a reflective and adaptive professional mindset. This study aims to analyze the transformation of counseling mindsets among guidance and counseling teachers after participating in the 7 Jurus BK Hebat training program, as well as to identify supporting and inhibiting factors. Using a mixed methods approach with a convergent design, the study involved 411 participants selected through convenience random sampling. Data were collected using a mindset transformation scale (α = .939) and open-ended questionnaires, then analyzed descriptively and thematically. The …
The Effect Of Vestibular System Stimulation On Emotional Regulation In Children With Disabilities, Mickayla N. Coyle
The Effect Of Vestibular System Stimulation On Emotional Regulation In Children With Disabilities, Mickayla N. Coyle
Student Capstone Papers
This capstone project is a mixed-methods research study that aimed to identify the impact of vestibular system stimulation on emotional regulation in children with disabilities. Throughout this research study, swing use was used as vestibular stimulation to identify its effectiveness in improving emotional regulation in children with disabilities. The study was conducted over the course of six weeks in a school-based setting. The results of this research study are indicative that using a swing as a vestibular input is an effective intervention to manage emotional regulation in children with disabilities. Utilization of linear swinging at the beginning of occupational therapy …
Occupational Therapy In Action: Enhancing Diabetes Awareness And Support In Rural Schools, Sierra Cook
Occupational Therapy In Action: Enhancing Diabetes Awareness And Support In Rural Schools, Sierra Cook
Student Capstone Papers
The rising prevalence of type 2 diabetes among adolescents highlights the need for early prevention-focused interventions. This capstone project developed and implemented an occupation-based educational program for middle school students targeting body awareness, nutrition, movement, and stress management. The program consisted of five interactive workshops addressing energy awareness, meal planning, social and environmental influences on health, movement-based regulation strategies, and coping skills. Hands-on activities, including energy check-ins, meal logs, movement stations, and coping toolbox development, were used to promote engagement and support the development of healthy routines.
Planning For The Transition To Adulthood: Parent Perspectives On The Planning Process And Experiences Of Young Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek Ph.D., Ccc-Slp, Julie Lounds Taylor, Angela John Thurman
Planning For The Transition To Adulthood: Parent Perspectives On The Planning Process And Experiences Of Young Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek Ph.D., Ccc-Slp, Julie Lounds Taylor, Angela John Thurman
Faculty Publications
Objectives
Relatively few young adults with fragile X syndrome (FXS) meet the normative expectations of adulthood, although there is heterogeneity in this regard. The present study examined the preparation for the transition to adulthood experienced by young adults with FXS and their parents.
Methods
Thirty-nine young adults with FXS and their primary caregiving parents participated. Those with FXS were in their last year of, or had recently left, high school or a formal transition program. Parents completed surveys about the formal transition planning process. We examined the role of the young adults’ adaptive behavior skills in transition planning.
Results
Among …
Powering Up Clinical Scholarship In Pain Management / Chronic Pain Fellowship, Evelyn Wang
Powering Up Clinical Scholarship In Pain Management / Chronic Pain Fellowship, Evelyn Wang
HSLIC Faculty and Staff Instructional Resources
This presentation introduces chronic pain fellows to clinical scholarship pathways in pain management, highlighting core literature search strategies, evidence‐based resources, and HSLIC services that support research, publishing, and teaching in chronic pain care.
Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li
Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li
Faculty, Staff and Students Publications
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of …
Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson
Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson
Faculty, Staff and Students Publications
Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial TCR profiling strategy that resolves individual T cell clones together with their transcriptional states at single-cell resolution and applied the method to human head and neck squamous cell carcinoma. Presumed tumor-specific T cells were broadly dispersed throughout the tumor microenvironment, and cells of the same clone occupied distinct transcriptional states in different locations: Immune-rich regions contained more plastic or progenitor cells, whereas tumor-dense regions were enriched …
A Tv-Bm3d Iterative Algorithm For Vmat-Ct Reconstruction, Chia-Lung Chien, Beibei Guo, Rui Zhang
A Tv-Bm3d Iterative Algorithm For Vmat-Ct Reconstruction, Chia-Lung Chien, Beibei Guo, Rui Zhang
Faculty, Staff and Students Publications
Volumetric modulated arc therapy-computed tomography (VMAT-CT), which is the CT reconstructed using the portal images collected during VMAT, can potentially be an effective onsite imaging tool. The goal of this study was to propose an iterative reconstruction algorithm that can further improve the image quality of VMAT-CT and reduce the number of failed reconstructions. An iterative algorithm combining total variation (TV) with block-matching and 3D filtering (BM3D) was proposed, addressing the L1-L2 regularization problem using the split Bregman method. We collected portal images from 67 VMAT cases including 50 phantom and 17 real-patient cases. Both Feldkamp-Davis-Kress (FDK) and TV-BM3D iterative …
Constitutive Ampk Activation Prevents Hepatocellular Carcinoma Development Through Inhibition Of Hnf4Α Activity, Zhen Sun, Bernard Linares, Cassidy Urdiales, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L Van Nostrand
Constitutive Ampk Activation Prevents Hepatocellular Carcinoma Development Through Inhibition Of Hnf4Α Activity, Zhen Sun, Bernard Linares, Cassidy Urdiales, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L Van Nostrand
Faculty, Staff and Students Publications
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and is largely driven by metabolic disorders such as obesity and type 2 diabetes. The AMP-activated protein kinase (AMPK) is a master regulator of metabolism, and its activation has been proposed as a therapeutic strategy for treating metabolic disorders. However, although AMPK activity is down-regulated in HCC, the precise role of AMPK in HCC development has not been clearly delineated. Here, we investigated the ability of constitutive AMPK activation to prevent HCC development using a constitutively active AMPK transgenic mouse model and a pharmacological AMPK activator. We observed that AMPK …
Current Status Of Msk Diagnostic Ultrasound Education In Doctorate Of Physical Therapy Programs In The United States: A Survey, Lesley Parrish Dr., Heather E. Mount, Casey Charlebois
Current Status Of Msk Diagnostic Ultrasound Education In Doctorate Of Physical Therapy Programs In The United States: A Survey, Lesley Parrish Dr., Heather E. Mount, Casey Charlebois
Innovations in Health Sciences Education Journal
Musculoskeletal ultrasound (MSK-US) is a dynamic, cost-effective imaging modality increasingly integrated into Doctor of Physical Therapy (DPT) curricula. Despite growing interest, variability exists in the integration and implementation of MSK-US in entry-level DPT programs. This study aimed to assess the current status of MSK-US education in accredited DPT programs across the United States. A cross-sectional survey was distributed to all 294 accredited DPT programs in the U.S. via email. The survey consisted of 32 questions that addressed curriculum content, instructional methods, faculty qualifications, and barriers to implementation. Participation was voluntary, and 44 programs responded. No experimental interventions were applied. The …
Emotional Intelligence Training In Physician Assistant Education: Comparing Workshops Alone To Workshops Plus Coaching, Mickey Lebowitz, William Holmes
Emotional Intelligence Training In Physician Assistant Education: Comparing Workshops Alone To Workshops Plus Coaching, Mickey Lebowitz, William Holmes
Innovations in Health Sciences Education Journal
Introduction
Clinicians and health care students with higher emotional intelligence (EQ) are more likely to experience positive outcomes for themselves and their patients. Given these benefits and EQ’s learnability, teaching EQ to health care students has been suggested. Therefore, we aimed to assess the impact of workshops combined with coaching (W+C) relative to workshops only (WO) on PA students’ EQ, and, as an outcome measure, their feelings of success. Additionally, we investigated whether these impacts depend on students’ baseline EQ.
Method
Using the Six Seconds Emotional Intelligence Inventory, we retrospectively tracked first- and second-year changes in EQ and success scores …
Career Adaptability Of Prospective Teachers With Disabilities In Indonesia: A Phenomenological Study, Rr Dwi Umi Badriyah, Erfan Ramadhani, Ramtia Darma Putri, Syska Purnama Sari, Amândio De Araújo Sarmento, Kadek Suhardita
Career Adaptability Of Prospective Teachers With Disabilities In Indonesia: A Phenomenological Study, Rr Dwi Umi Badriyah, Erfan Ramadhani, Ramtia Darma Putri, Syska Purnama Sari, Amândio De Araújo Sarmento, Kadek Suhardita
Jurnal Kajian Bimbingan dan Konseling
Pre-service teachers with disabilities face career transitions shaped by personal aspirations, accessibility barriers, stigma, and limited role models. In Indonesia, little is known about how they build career readiness for teaching within inclusive unequal educational contexts. This study explores the career adaptability of pre-service teachers with disabilities in Indonesia. Grounded in Career Construction Theory, it examines concern, control, curiosity, and confidence, while extending the framework by considering resilience and flexibility as relevant dimensions. A qualitative phenomenological design was used. Twenty-five students with disabilities enrolled in Primary School Teacher Education and Special Education programs at an Indonesian university participated in semi-structured …
Therapeutic Potential Of Glp-1 Receptor Agonists For Smoking Cessation, Christian S Hendershot, W Kyle Simmons, Manish K Jha, Sherry A Mckee, Luba Yammine
Therapeutic Potential Of Glp-1 Receptor Agonists For Smoking Cessation, Christian S Hendershot, W Kyle Simmons, Manish K Jha, Sherry A Mckee, Luba Yammine
Faculty, Staff and Student Publications
Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among people who smoke. Given modest quit rates with approved smoking cessation therapies, medications with novel mechanisms of action are needed to expand the available monotherapy and combination treatment options. Treatments that prevent post-cessation weight gain could further reduce relapse and cardiometabolic risks following smoking cessation. Preclinical findings show that GLP-1 receptor agonists (GLP-1RA) modulate nicotine reward, reduce nicotine self-administration, and …
A Machine-Learning-Based Tool For Stroke Risk Prediction In Blunt Cerebrovascular Injury: Development And Preliminary Evaluation, Victoria Wagner, Joshua D Preston, Alejandro De Leon Castro, William F Mueller, Jonathan Nguyen, Manuel Garcia-Toca, Elizabeth R Benjamin, S Rob Todd, Jason D Sciarretta
A Machine-Learning-Based Tool For Stroke Risk Prediction In Blunt Cerebrovascular Injury: Development And Preliminary Evaluation, Victoria Wagner, Joshua D Preston, Alejandro De Leon Castro, William F Mueller, Jonathan Nguyen, Manuel Garcia-Toca, Elizabeth R Benjamin, S Rob Todd, Jason D Sciarretta
Faculty, Staff and Student Publications
Purpose: Stroke risk correlates with the Biffl grading system in blunt cerebrovascular injury (BCVI). Although anti-thrombotic therapy is the mainstay of stroke prevention, no point-of-care clinical decision-support tool exists to guide timing for therapy. We sought to develop an interactive online calculator that incorporates patient-specific demographic and injury characteristics to estimate stroke risk and risk reduction with anti-thrombotic (AT) administration.
Methods: Data from BCVI patients (n = 1,197) at a Level I Trauma Center were retrospectively collected. Six machine learning methods were employed to predict stroke risk with and without AT therapy. Class imbalance was addressed using downsampling and/or class …
A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink
A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink
Faculty, Staff and Student Publications
While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …
Etalanetug (E2814) In Dominantly Inherited Alzheimer's Disease: An Open-Label Phase 1b/2 Study To Assess Safety And Target Engagement In Participants With Mild To Moderate Cognitive Impairment, Erica Andreozzi, Kanta Horie, Nicolas R Barthélemy, Brian A Gordon, Shaney Flores, Tammie L S Benzinger, Eric Mcdade, Randall J Bateman, Et Al.
Etalanetug (E2814) In Dominantly Inherited Alzheimer's Disease: An Open-Label Phase 1b/2 Study To Assess Safety And Target Engagement In Participants With Mild To Moderate Cognitive Impairment, Erica Andreozzi, Kanta Horie, Nicolas R Barthélemy, Brian A Gordon, Shaney Flores, Tammie L S Benzinger, Eric Mcdade, Randall J Bateman, Et Al.
2020-Current year OA Pubs
INTRODUCTION: Etalanetug (E2814) is designed to delay the clinical progression of Alzheimer's disease (AD) by binding to the microtubule binding region (MTBR) of tau implicated in seeding and spreading of tau pathology. Dominantly inherited Alzheimer's disease (DIAD) is a rare form of the disease (< 1%), having similar changes in the tau distribution and pathology to sporadic AD. Herein, we report the safety, pharmacology and biomarker results of the etalanetug Study 103 in DIAD patients.
METHODS: Study 103 enrolled participants with mild-to-moderate cognitive impairment due to DIAD who received etalanetug intravenously every 4 weeks escalating from 750 mg, 1500 mg, 3000 mg, to 4500 mg. After ascending to 4500 mg, patients received 4500 mg for up to 108 weeks. Tau pathology biomarkers, ptau217 and MTBR-tau243 were measured in CSF. Additional …
From Vision To Impact: Building A Sustainable Open-Access Peer Reviewed Medical Journal, Darshana T. Shah Phd
From Vision To Impact: Building A Sustainable Open-Access Peer Reviewed Medical Journal, Darshana T. Shah Phd
All Things Open
The Marshall Journal of Medicine (MJM) was created to strengthen scholarly exchange, clinical innovation, and health professions education in rural Appalachia while making that work openly accessible to readers worldwide. As West Virginia’s first fully open‑access, online, peer‑reviewed medical journal, MJM illustrates how a mission‑driven publishing effort can evolve from an initial idea into lasting scholarly infrastructure—and how publication activity can translate into measurable impact.
MJM’s development centered on three strategic pillars:
- a clearly articulated scope focused on clinically relevant and educationally innovative scholarship
- rigorous peer‑review and editorial practices that ensure credibility and quality
- operational partnerships—especially with academic …