Medicine and Health Sciences Commons^™

การศึกษาสมรรถนะพยาบาลในหออภิบาลผู้ป่วยหนักรวมตามบันไดอาชีพ โรงพยาบาลระดับทุติยภูมิ, สุนีย์ ยี่สุ่น

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยเชิงพรรณนานี้ มีวัตถุประสงค์เพื่อศึกษาสมรรถนะพยาบาลในหออภิบาลผู้ป่วยหนักรวมตามบันไดอาชีพ โรงพยาบาลระดับทุติยภูมิ โดยใช้เทคนิคการวิจัยแบบเดลฟาย ผู้ให้ข้อมูลคือ กลุ่มผู้เชี่ยวชาญจำนวน 23 คน ประกอบด้วยกลุ่มแพทย์ผู้เชี่ยวชาญด้านการดูแลผู้ป่วยวิกฤต กลุ่มผู้เชี่ยวชาญด้านการบริหารหออภิบาลผู้ป่วยหนักรวม กลุ่มผู้เชี่ยวชาญด้านการบริหารองค์การพยาบาล กลุ่มผู้เชี่ยวชาญด้านวิชาการ กลุ่มผู้เชี่ยวชาญด้านการพยาบาลเฉพาะทางผู้ป่วยวิกฤต และกลุ่มผู้เชี่ยวชาญด้านการปฏิบัติการพยาบาลขั้นสูง วิธีดำเนินการวิจัยประกอบด้วย 3 ขั้นตอนคือ ขั้นตอนที่ 1 สัมภาษณ์เกี่ยวกับสมรรถนะพยาบาลในหออภิบาลผู้ป่วยหนักรวมตามบันไดอาชีพ โรงพยาบาลระดับทุติยภูมิ ขั้นตอนที่ 2 นำข้อมูลที่ได้มาวิเคราะห์เนื้อหาแล้วนำมาสร้างแบบสอบถามให้ผู้เชี่ยวชาญได้แสดงความคิดเห็นเกี่ยวกับระดับความสำคัญของข้อคำถามในแต่ละข้อ และขั้นตอนที่ 3 นำข้อมูลที่ได้มาคำนวณค่ามัธยฐานและค่าพิสัยระหว่างควอไทล์ แล้วกลับไปให้ผู้เชี่ยวชาญยืนยันความคิดเห็นเพื่อสรุปผลการวิจัย ผลการวิจัยพบว่า สมรรถนะพยาบาลในหออภิบาลผู้ป่วยหนักรวมตามบันไดอาชีพ โรงพยาบาลระดับ ทุติยภูมิ ประกอบด้วย 7 ด้าน ดังนี้ 1) ด้านการพยาบาลผู้ป่วยวิกฤต 2) ด้านการบริหารยาความเสี่ยงสูงที่ใช้ในผู้ป่วยวิกฤต 3) ด้านการสื่อสารและการประสานงานเพื่อการรักษาพยาบาล 4) ด้านการป้องกันและจัดการกับภาวะแทรกซ้อน 5) ด้านการพยาบาลผู้ป่วยวิกฤตระยะสุดท้าย 6) ด้านการใช้อุปกรณ์ทางการแพทย์และเทคโนโลยีสารสนเทศ และ 7) ด้านการจัดการ และควบคุมคุณภาพการดูแลผู้ป่วย ซึ่งพยาบาลที่ปฏิบัติงานในหออภิบาลผู้ป่วยหนักรวม ประกอบด้วยพยาบาลระดับปฏิบัติการ ชำนาญการ และชำนาญการพิเศษ ที่มีสมรรถนะทั้ง 7 ด้าน แต่รายการสมรรถนะย่อยมีความแตกต่างกันดังนี้ พยาบาลระดับปฏิบัติการ สามารถให้การพยาบาลผู้ป่วยวิกฤตและปฏิบัติงานอื่นๆ ในระดับพื้นฐาน และอยู่ภายใต้การดูแลของพยาบาลที่มีประสบการณ์มากกว่า พยาบาลระดับชำนาญการ สามารถนำความรู้เชิงลึกมาใช้ในการพยาบาลผู้ป่วยวิกฤตที่มีภาวะซับซ้อนและปฏิบัติงานร่วมกับทีมสหสาขาวิชาชีพได้อย่างมีประสิทธิภาพ พยาบาลระดับชำนาญการพิเศษ สามารถนำความรู้เชิงลึกมาใช้ในการพยาบาลผู้ป่วยวิกฤตที่มีภาวะยุ่งยากและซับซ้อน แก้ปัญหาเฉพาะหน้าได้อย่างรวดเร็วและมีประสิทธิภาพ และพัฒนาคุณภาพการพยาบาลจากหลักฐานเชิงประจักษ์ได้

Association Of Genetic Polymorphisms With Clinical Characteristics And Survival Of Hepatocellular Carcinoma Patients With Or Without Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld), Theint Cho Zin Aung

Chulalongkorn University Theses and Dissertations (Chula ETD)

The influence of single-nucleotide polymorphisms (SNPs) on hepatocellular carcinoma (HCC) in terms of etiological factors remains to be explored. This study evaluated the distribution of PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs6834314 and overall survival of HCC patients with metabolic dysfunction-associated steatotic liver disease (MASLD-HCC) and viral-related HCC (VIRAL-HCC). In this study, 564 patients with HCC were included: 254 with MASLD-HCC and 310 with VIRAL-HCC. The SNPs were determined by real-time PCR using TaqMan assays. Results: The mean ages of patients with MASLD-HCC and VIRAL-HCC were 68.4 vs. 60.9 years (p < 0.001), with a significant difference between groups. The prevalence of PNPLA3 genotype GG in MASLD-HCC was significantly higher in MASLD-HCC than in VIRAL-HCC (24.0 % vs. 15.5%; OR = 1.86; 95% CI = 1.14–3.05; p = 0.009). Similarly, the prevalence of TM6SF2 genotype TT in MASLD-HCC and VIRAL-HCC was 7.1% vs. 2.6% (OR = 3.39; 95% CI = 1.36–9.21; p = 0.003), while HSD17B13 genotype GG in the corresponding groups was 7.1% vs. 12.6% (OR = 0.53; 95 % CI = 0.27–1.01; p = 0.039). The overall median survival of MASLD-HCC was significantly shorter than the VIRAL-HCC group (42 vs. 66 months; p = 0.035). In Cox regression hazard analysis, HSD17B13 GG genotype was significantly associated with a lower mortality rate in MASLD-HCC (HR = 0.38 ; 95% CI = 0.18–0.81; p = 0.011). In contrast, PNPLA3 and TM6SF2 were not associated with overall survival in patients with MASLD-HCC or VIRAL-HCC. Conclusions: These data demonstrated that the prevalence of the studied SNPs significantly differed between MASLD-HCC and VIRAL-HCC. The HSD176B13 GG genotype was also associated with a survival benefit in Thai patients with MASLD-HCC.

Crosstalk Between Cytokines And The Diverse Pattern Of Tumor Immune Microenvironment (Time) In Egfr Mutant Advanced Stage Non-Small Cell Lung Cancer Receiving Egfr Tyrosine Kinase Inhibitor, Sorawich Kuendee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Although EGFR-TKI therapy significantly improves outcomes in patients with EGFR-mutant advanced NSCLC, inter-individual variability in treatment response remains a major challenge. One potential contributing factor is the tumor immune microenvironment (TIME), which plays a critical role in tumor behavior and may influence therapeutic efficacy. However, the relationship between baseline cytokine profiles and TIME features in this patient population remains unclear. Methods: Prospective observational study involving patients with advanced EGFR-mutant NSCLC receiving first-line EGFR-TKI therapy. Baseline cytokine levels were measured using the Bio-Plex Pro™ Human 27-Plex Cytokine Assay. Immunohistochemistry was used to evaluate CD8⁺ TILs and PD-L1 expression. The primary …

Scalp Fast Oscillation As A Predictor For Epilepsy In Critically Ill Patients With Periodic Discharges, Kongpop Sutantikorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Periodic discharges (PDs) in critically ill patients due to diverse pathologies are not uncommon and carry varied prognosis. Scalp fast oscillations (SFOs) have been increasingly studied its association with clinical outcomes in many conditions. However, none has assessed its values in prognostication of the critically ill patients. Objectives: To assess the prognostic values of SFOs in prediction of short and long-term clinical outcomes in critically ill patients with PDs. Materials and Methods: All patients aged > 15 years with detection of PDs during 2014-2022 were recruited. Converted electroencephalography (EEG) files to the standard format were used for analysis. Time-frequency analysis …

Roles Of Mtor Complex 2 Signaling In The Sphingolipid Production Of Brain Cancer Cell Lines, Nuanwan Songcharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Gliomas, which include low- and high-grade types, represent a particularly aggressive form of primary brain tumor, especially glioblastoma (GBM). Metabolic reprogramming in lipid metabolism supports cell proliferation; alterations in the sphingolipid pathway, elevated glucosylceramide (GlcCer) levels through glucosylceramide synthase (GCS), promote the production of glycosphingolipids, which serve as building blocks for cancer cells. Furthermore, mTORC2, which is a kinase protein, contributes to lipid metabolism. Thus, the study aims to investigate the roles of mTORC2 signaling in lipid metabolism through lipid accumulation, which was reduced with AZD8055 treatment as the mTORC2 inhibitor. Additionally, p-AKT (S473), which is downstream of mTORC2, was …

Assessment Of Interest In A Virtual Avatar-Based Nutrition Education Program Among Youth-Serving Community Partners, Basheerah Enahora, Gina L. Tripicchio, Regis Kopper, Omari L. Dyson, Jeffrey Labban, Lenka H. Shriver, Lauren A. Haldeman, Christopher K. Rhea, Jared T. Mcguirt

Rehabilitation Sciences Faculty Publications

Objective

Examine the appeal of a virtual avatar-led nutrition education program among youth-serving community partners in North Carolina.

Methods

We surveyed community partners using the Diffusion of Innovation Theory constructs of relative advantage, compatibility, and complexity. Logistic regression evaluated the appeal and likelihood of the program's future use.

Results

Community partners (n = 100) agreed that the program was an innovative (87%) and convenient (85%) way for youth and parents to learn about nutrition. Partners who perceived the program as a relative advantage to current programs had significantly higher odds of future use intention (P = 0.005). Those who found …

Effect Of Task Constraints On Neurobiological Systems Involved In Postural Control In Individuals With And Without Chronic Ankle Instability, Yuki A. Sugimoto, Patrick O. Mckeon, Christopher K. Rhea, Carl G. Mattacola

Rehabilitation Sciences Faculty Publications

The purpose of this study is to investigate the effect of task constraints on the neurobiological systems while maintaining postural control under various sensory feedback manipulations in individuals with and without Chronic Ankle Instability (CAI). Forty-two physically active individuals, with and without CAI, were enrolled in a case-control study conducted at a biomechanics research laboratory. All participants underwent the Sensory Organization Test (SOT), which assesses individuals’ ability to integrate somatosensory, visual, and vestibular feedback to maintain postural control in double-, uninjured-, and injured-limb stances under six different conditions in which variations in the sway-referenced support surface (platform) and visual surroundings, …

Clothing Design Solutions For Children With Developmental Disabilities: A Scoping Review Protocol, Nagaveni N. Nayak, Shristi Shakya, Nachiket Gudi, Sonia Khurana, Sivakumar Gopalakrishnan, Veena Rao, Bhamini Krishna Rao

Rehabilitation Sciences Faculty Publications

Children with Developmental Disabilities (DD) often face significant challenges in performing dressing task, fundamental activities of daily living. Inability to accomplish this task independently significantly impacts participation in social and recreational activities, affecting Quality of Life (QoL). Additionally, burden on caregivers increases which in turn leads to stress and burnout. Addressing dressing-related challenges through innovative clothing designs enhances self-independence, alleviate caregiver burden, and improve QoL. However, studies published in this focused area are quite heterogeneous resulting in lack of comprehensive understanding of different clothing solutions that exist for children with DD. Therefore, this scoping review is undertaken to map clothing …

Prediction Of Recurrent Lateral Ankle Sprain And Ankle Pain Using Applied Care Strategies And Patient-Reported Outcomes, Ryan S. Mccann, Elisabeth Ohrnberger, Kyle B. Kosik, Phillip A. Gribble

Rehabilitation Sciences Faculty Publications

Context

Patients with lateral ankle sprains (LASs) often have deficient patient-reported outcomes (PROs) at return to activity (RTA), potentially increasing risk for recurrent LAS and ankle pain. Additionally, applied care strategies are known to correct impairments, but their ability to mitigate risk for long-term consequences remains unknown.

Objective

To determine if applied care strategies and PRO scores at RTA and 6 months after RTA predict recurrent LAS and ankle pain 12 months after an acute LAS. DESIGN: Prospective cohort study.

Setting

Online survey.

Patients or Other Participants

We enrolled 63 individuals within 1 week of sustaining an acute LAS.

Main …

Athletic Trainers' Perceptions Of The Structure And Barriers To Online Continuing Education Clinical Documentation Models, Sara L. Nottingham, Tricia M. Kasamatsu, Julie M. Cavallario, Cailee E. Welch Bacon

Rehabilitation Sciences Faculty Publications

Context: Athletic trainers (ATs) appreciate the accessibility of web-based continuing education (CE) opportunities. ATs describe needing more CE opportunities related to clinical documentation, but the effectiveness of CE in this content area has not been studied.

Objective: Obtain ATs’ perceptions of their experiences accessing web-based CE specific to clinical documentation.

Design: Qualitative study.

Setting: Web-based audio interviews.

Patients or Other Participants: Twenty-nine ATs, averaging 36.2 ± 9.0 years of age, including 16 women and 13 men who represented 8 different clinical practice settings.

Data Collection and Analysis: Participants previously completed 1 of 2 web-based CE modules specific to clinical documentation, …

Retention And Transfer Of Fractal Gait Training, Logan J. Frame, Nikita A. Kuznetsov, Louisa D. Raisbeck, Christopher K. Rhea

Rehabilitation Sciences Faculty Publications

Background/Purpose: Fractal gait patterns have been shown to be modifiable, but the extent to which they are retained and transferred to new contexts is relatively unknown. This study aimed to close those gaps by enrolling participants (N = 23) in a seven-day fractal gait training program. Methods: Building on related work, the fractal gait training occurred on a treadmill over a 10-min period. Before and after the treadmill training, each participant walked for 10 min overground without the fractal stimulus used during training. The daily post-test was used to examine immediate retention and transfer of the fractal gait patterns from …

Lecture-Based Instruction On Salary Negotiation For Professional Athletic Training Students: An Educational Technique, Julie M. Cavallario, Thomas R. Campbell, Cailee E. Welch Bacon

Rehabilitation Sciences Faculty Publications

Context

Low salary is a frequently cited reason for attrition from the athletic training profession. Researchers have determined that athletic trainers (ATs) entering the first hiring process, usually newly credentialed graduates of professional athletic training programs (ATPs), are the least likely to negotiate, resulting in lowered earning potential across their careers. It is necessary to instruct athletic training students on the importance of salary negotiation before the completion of their professional preparation.

Objective

Describe a lecture-based approach to include salary negotiation content into ATPs.

Background

Employing constructivist learning theory, didactic lecture content with applicable strategies for salary negotiation is sufficient …

Perception, Awareness, And Practices Toward The Pm2.5 During The Air Pollution Episode Among Chinese Students In Bangkok And Vicinity, Thailand: A Cross-Sectional Study, Jiali Chen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Air pollution poses a significant public health threat to urban populations worldwide. Mobile groups such as international students face unique vulnerabilities, but their risk adaptation capacity remains understudied. This study assessed awareness, perception, and protective measures of PM2.5 among Chinese international students in Bangkok and its vicinity. This study used a validated scale to conduct a cross-sectional survey of 393 participants. The results revealed that while students exhibited a high level of risk perception regarding air pollution (mean score: 48.0 ± 7.6), their awareness was relatively low (mean score: 6.3 ± 2.9), with only 3.8% of respondents demonstrating "high awareness". …

Effectiveness Of Parent-Focused Switch Program For Increasing Fruit And Vegetable Consumption Among Elementary School Students In Yangon, Myanmar: Quasi-Experimental Study, Htet Myat Aung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Fruit and vegetable consumption will enhance human health because of their nutritional composition. A balanced diet should consist of at least 400g (5 servings) of fruits and vegetables per day according to the World Health Organization (WHO). Inadequate consumption of fruits and vegetables was linked to 19% of gastrointestinal cancer, 31% of ischemic heart disease, and 11% of strokes globally. Additionally, there were 26.7 million (1.8%) DALYs and 2.7 million (4.9%) deaths due to poor fruit and vegetable intake. This study assessed the effectiveness of Switch program on increasing fruit and vegetable consumption among elementary school students in Yangon, …

Determination Of Nutrients Digestibility In Commercial Dry Dog Food Containing Various Protein Sources, Phuong Anh Ta

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated the nutritional adequacy and digestibility of commercial dry dog foods formulated with different protein sources (animal versus plant) and market tiers (premium versus economy). Eight commercial dog foods were analyzed for nutrient composition and amino acid profiles using proximate analysis and high-performance liquid chromatography (HPLC). Of these, four representative products were selected to assess digestibility through in vivo total fecal collection in Beagle dogs and in vitro digestion assays. All products exceeded 18% crude protein (the minimum crude protein requirement by AAFCO). However, deficiencies were examined in essential amino acids, particularly leucine, isoleucine, methionine, lysine, tryptophan, valine …

Models Of Video Feedback For Youth Athletes Performing An American Football Tackle, Eric Schussler, Richard J. Jagacinski, Ajit Chaudhari, John A. Buford, James A. Onate

Rehabilitation Sciences Faculty Publications

Context: Video feedback is an expeditious method for improving athlete safety when performing activities with an inherent risk of injury. Providing appropriate and validated feedback during tackling training in American football may be a mechanism for athletes to learn safe tackling performance.

Objective: To determine the effect of video feedback in the instruction of tackling form.

Design: Controlled laboratory study.

Setting: Laboratory.

Patients or Other Participants: A total of 32 youth football athletes (28 boys, 4 girls; age ¼ 11.8 6 0.8 years) participated in 1 day of training. Of those, 14 participants completed 2 additional days of training and …

Influences Of Athletic Trainers' Return-To-Activity Assessments For Patients With An Ankle Sprain, Ryan S. Mccann, Cailee E. Welch Bacon, Ashley M. B. Suttmiller, Phillip A. Gribble, Julie M. Cavallario

Rehabilitation Sciences Faculty Publications

Context: Athletic trainers (ATs) inconsistently apply rehabilitation-oriented assessments (ROASTs) when deciding return-to-activity readiness for patients with an ankle sprain. Facilitators and barriers that are most influential to ATs' assessment selection remain unknown.

Objective: To examine facilitators of and barriers to ATs' selection of outcome assessments when determining return-to-activity readiness for patients with an ankle sprain.

Design: Cross-sectional study.

Setting: Online survey.

Patients or other participants: We sent an online survey to 10 000 clinically practicing ATs. The survey was accessed by 676 individuals, of whom 574 submitted responses (85% completion rate), and 541 respondents met the inclusion criteria.

Main outcome …

Patient Satisfaction Among Saudi Academic Hospitals: A Systematic Review, Ahmed Ali Alasiri, Saad A. Alotaibi, Eric Schussler

Rehabilitation Sciences Faculty Publications

Purpose: To systematically review the patient's satisfaction (PS) levels within academic hospitals in Saudi Arabia from January 2012 to the end of October 2022.

Data Sources: Articles were gathered from PubMed, ProQuest, Google Scholar and Web of Science.

Study selection/data extraction: This review identified studies that assessed PS in Saudi Arabian university hospitals. Articles published before January 2012, as well as commentary letters, conference papers, theses and dissertations, were excluded. The study employed the five domains of PS as outlined by Boquiren et al. Two independent reviewers independently identified qualifying studies, used the Joanna Briggs Institute tools …

Perceptions And Use Of The Athletic Training Milestones In Education: A Report From The Aate Research Network, Cailee Welch Bacon, Barton Anderson, Julie Cavallario, Bonnie Van Lunen, Lindsey Eberman

Rehabilitation Sciences Faculty Publications

The Athletic Training Milestones (AT Milestones) were developed as an evaluation tool to capture the breadth and depth of athletic training knowledge, skills, and behavior. However, it is unclear whether athletic training programs are implementing this tool or how they are implementing it to gauge the athletic training clinical progression of students or residents. We aimed to explore the perceptions and use of the AT Milestones among educators in athletic training programs. We used a cross-sectional, web-based survey with open-ended questions to collect data from athletic training programs on if and how they implement the AT Milestones at a programmatic …

Muslim Collegiate Student-Athletes' Experience With Fasting During Ramadan While Participating In Sport, Mishaal Amjad, Julie M. Cavallario, Nicolette A. Harris, Cailee E. Welch Bacon

Rehabilitation Sciences Faculty Publications

Context: As colleges and universities continue to focus on creating diverse, equitable, and inclusive environments, it is important to gain more knowledge on the experiences that Muslim student-athletes have while fasting during the month of Ramadan. While previous researchers have investigated the physical effects of fasting on the body, little is known about the challenges or support Muslim student athletes experience while fasting and participating in sport during Ramadan.

Objective: To explore the experiences of Muslim collegiate student-athletes regarding fasting during Ramadan while participating in sports.

Design: Consensual qualitative research.

Setting: Individual video interviews.

Participants: 12 Muslim collegiate student-athletes (4 …

Multifactorial Exercise Intervention Decreases Falls Risk In High-Risk And Low-Risk Older Adults, Amanda Estep, Steven Morrison, Shane V. Caswell, Jatin P. Ambegaonkar, João R. Vaz, Nelson Cortes

Rehabilitation Sciences Faculty Publications

Background: Each year, 1 in 4 people over the age of 65 years of age will experience a fall. It is important to identify and address modifiable risk factors that are associated with falls in adults at high and low risk for falls.

Hypothesis: Falls risk improves in both high-risk and low-risk participants with the implementation of Stay Active and Independent for Life (SAIL).

Study Design: Cohort study.

Level of Evidence: Level 3.

Methods: Seventy-eight older adults (age, 70.9 ± 5.1 years) were included in this study and categorized into high risk and low risk for falling based on the …

Effect Of Alkaline Water In Controlling Oral Ph, Duc M. Nguyen

Dental Hygiene ETDs

This study was motivated by the widespread prevalence of dental caries, acknowledged as a global concern and often deemed a pandemic, coupled with the realization of limitations in existing caries prevention methods. The surge in the popularity of alkaline water for daily use, recognized for its health benefits, prompted an exploration of its potential role in averting dental caries. The central hypothesis, focusing on the remineralization benefits of alkaline water as a preventive method for dental caries, formed the basis of investigation. Structured with two phases and five steps, the study aimed to evaluate the impact of alkaline water on …

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2024, Michael Haederle, Claire Hannon, Nicole San Roman, Jett Loe, Sara Mota, Sarah Head

Research Annual Reports

Annual research report from the University of New Mexico Health Sciences Center.

Estimation Of Differential Pathlength Factor From Nirs Measurement In Skeletal Muscle, B. Koirala, A. Concas, A. Cincotti, Yi Sun, A. Hernández, M. L. Goodwin, L. B. Gladden, N. Lai

Electrical & Computer Engineering Faculty Publications

The utilization of continuous wave (CW) near-infrared spectroscopy (NIRS) device to measure non-invasively muscle oxygenation in healthy and disease states is limited by the uncertainties related to the differential path length factor (DPF). DPF value is required to quantify oxygenated and deoxygenated heme groups' concentration changes from measurement of optical densities by NIRS. An integrated approach that combines animal and computational models of oxygen transport and utilization was used to estimate the DPF value in situ. The canine model of muscle oxidative metabolism allowed measurement of both venous oxygen content and tissue oxygenation by CW NIRS under different oxygen delivery …

Enhancement Of Antitumor Effects Of Berberine Chloride With A Copper(Ii) Complex Against Human Triple Negative Breast Cancer: In Vitro Studies, Duaa R. Alajroush, Brittney F. Anderson, Janae A. Bruce, Christian I. Lartey, Dazonte A. Mathurin, Sean T. Washington, Tanaya S. Washington, Sidy Diawara, Sakariyau A. Waheed, Kaylin L. Thomas, Stephen J. Beebe, Alvin A. Holder

Chemistry & Biochemistry Faculty Publications

In this study, the copper(II) complex [Cu(chromoneTSC)Cl₂]•0.5H₂O•0.0625C₂H₅OH (where chromoneTSC = (E)-N-Ethyl-2-((4-oxo-4H-chromen-3-yl)methylene)-hydrazinecarbothioamide) was synthesized and characterized; then used to carry out in vitro studies in combination with berberine chloride (BBC). The ligand and complex were characterized by elemental analysis, FTIR and NMR (¹H and ¹³C) spectroscopy, and conductivity measurements. The cytotoxic effect was analyzed by using the CCK-8 viability assay in cancer MDA-MB-231 VIM RFP and non-cancer MCF-10A cell lines. The IC₅₀ values for the complex and BBC were 21.2 ± 1.6 and 48.3 ± 2.4 μM, respectively at 24 h incubation, while the IC₅₀ value of the combination treatment …

The Impact Of Iron Supplementation On The Preterm Neonatal Gut Microbiome: A Pilot Study, Matthew Van Ormer, Maranda Thompson, Melissa Thoene, Jean-Jack Riethoven, Sathish Kumar Natarajan, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

OBJECTIVE: The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurodevelopment. However, excess colonic iron exhibits potent oxidation capacity and alters the gut microbiome-potentially facilitating the proliferation of pathological bacterial strains. Breastfed preterm infants routinely receive iron supplementation starting 14 days after delivery and are highly vulnerable to morbidities associated with gastrointestinal dysbiosis. Therefore, we set out to determine if routine iron supplementation alters the preterm gut …

Bioactive Metabolites Of Omega-6 And Omega-3 Fatty Acids Are Associated With Inflammatory Cytokine Concentrations In Maternal And Infant Plasma At The Time Of Delivery, Rebecca Slotkowski, Matthew Van Ormer, Anum Akbar, Taija Hahka, Maranda Thompson, Rebekah Rapoza, Arzu Ulu, Melissa Thoene, Elizabeth Lyden, Maheswari Mukherjee, Ana G. Yuil-Valdes, Sathish Kumar Natarajan, Tara Nordgren, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

Background & aims

Inflammation is necessary for a healthy pregnancy. However, unregulated or excessive inflammation during pregnancy is associated with severe maternal and infant morbidities, such as pre-eclampsia, abnormal infant neurodevelopment, or preterm birth. Inflammation is regulated in part by the bioactive metabolites of omega-6 (n-6) and omega-3 (n-3) fatty acids (FAs). N-6 FAs have been shown to promote pro-inflammatory cytokine environments in adults, while n-3 FAs have been shown to contribute to the resolution of inflammation; however, how these metabolites affect maternal and infant inflammation is still uncertain. The objective of this study was to predict the influence of …

Promoting Inpatient Mobility To Improve Patient Outcomes: A Quality Improvement Project In A Rural Critical Access Hospital, Chantal Laplante

Master's Theses and Capstones

Background: Although beneficial to patient outcomes, inpatient ambulation is not a prioritized care intervention, and a task often deferred to physical therapy. Patient immobility is a complex problem that requires a multifaceted approach.

Local Problem: In a rural, critical access hospital, on an 18-bed medical surgical unit, nursing staff lacked ownership of patient mobility. There was no standardized process to document ambulation and mobility tasks were not scheduled, falling to the end of the nursing work list. Many patients did not have activity orders upon admission and nurses lacked resources for ambulation assessment and daily goal setting. There was no …

Using The Stop5 Debriefing Model To Increase Utilization Of Debriefing Practice In The Emergency Department: A Quality Improvement Project, Hallie Chancey

Master's Theses and Capstones

Abstract Background: The practice of debriefing has been an important process in critical care settings to promote team unity as well as best care practices. Literature has shown that debriefing can not only influence quality care and improved operations, but the process can also influence the emotional support staff receive. These implications are particularly important for nurses that work in critical care settings as the job can often be stressful and lead to moral distress as well as the need for evidence-based care practices is crucial when a patient’s life is on the line. Literature supports that any form of …

Using Education To Improve Glycemic Management Within An Emergency Department, Rebecca Olson

Master's Theses and Capstones

Background: Patients with diabetes mellitus (DM) frequently visit acute care facilities for a variety of reasons. Proper management of this comorbidity increases patient safety, satisfaction, and quality care. Patients with persistent dysglycemic events in acute care facilities have an increased risk of complications and death during their stay. Lack of education can contribute to gaps in proper management within this population and therefore must be improved for better patient outcomes.

Methods: The Plan-Do-Check-Act design from the A3 Problem Solving model was used to guide a quality improvement project which focused on improving staff education and confidence surrounding glycemic management. The …