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Full-Text Articles in Medicine and Health Sciences

Enhancing Pelvic Floor Rehabilitation Referral Through Accessible Education For Clinicians And Patients, Madelyn Murphy Jan 2024

Enhancing Pelvic Floor Rehabilitation Referral Through Accessible Education For Clinicians And Patients, Madelyn Murphy

Occupational Therapy Doctorate Capstone Posters

Pelvic floor dysfunction has been identified as a significant public health issue and is estimated to affect around 50% of women. Still, less than 25% seek medical help and only 12% receive subspecialty care (Yohay et al., 2022). Studies show a lack of knowledge among women and their providers and that education programs are necessary to fill this gap (Yohay et al., 2022). After surveying both doctors and patients at Med Center Health, this project aimed to fill this educational gap by developing an educational video program. This program targeted both doctors and patients, aiming to increase awareness about pelvic …


Program Development Of Pediatric Therapy Clinic For Rural Hospital, Mauri Rhodes Jan 2024

Program Development Of Pediatric Therapy Clinic For Rural Hospital, Mauri Rhodes

Occupational Therapy Doctorate Capstone Posters

This capstone project focuses on addressing the critical need for pediatric occupational therapy services in rural western Kentucky. The purpose of this project and experience was to assist in program development of a comprehensive resource for Livingston Hospital to guide the establishment of a pediatric therapy gym including clinic design, equipment suggestions, and various marketing and survey components. The main goals that were completed throughout this experience included: design/develop an outpatient pediatric therapy gym, examine current outpatient pediatric clinics’ practices and procedures, inspect current pediatric therapy clients’ parents and current hospital workers feelings/thoughts/ideas on rural outpatient pediatric therapy, and design …


Implementing Nature-Based Occupational Therapy In School-Based Settings, Megan Evans Jan 2024

Implementing Nature-Based Occupational Therapy In School-Based Settings, Megan Evans

Occupational Therapy Doctorate Capstone Posters

In school-based settings, Occupational Therapists work with students on various areas related to a student's Individualized Learning Plan (IEP). As technology use increases in academic settings for young students and time spent outdoors decreases, the exploration of a potential solution to this relationship was discovered. Nature-Based Occupational Therapy is an emerging practice area focused on incorporating outdoor play and materials from the outdoors into treatment sessions while still addressing areas of concern to increase a child’s independence in daily occupations.

This capstone project focused on four objectives:

  1. Design a nature-based activity guide for students in the school system setting that …


Effects Of Providing A Moho-Informed Education Session For College Peer-Mentor Self-Efficacy, Sarah Roberts Jan 2024

Effects Of Providing A Moho-Informed Education Session For College Peer-Mentor Self-Efficacy, Sarah Roberts

Occupational Therapy Doctorate Capstone Posters

As an occupational therapy student, I recognized the support our profession can offer to assist with various student and faculty needs across campus, specifically peer mentor programs. A thorough literature review illustrated limited representation for peer mentor roles, expectations, and potential impact on retention. Along with these findings, it was revealed that academic outcomes improve with involvement in evidence-based interventions as well as support for the Model of Human Occupations (MoHO) to understand and support human well-being.With this in mind, this study sought to develop and implement an evidence-based education session to identify and improve resources for peer mentors and …


Grow As We Go: Education, Efficacy, And Empowerment For Life Skills Trainers, Shelby Mitchell Jan 2024

Grow As We Go: Education, Efficacy, And Empowerment For Life Skills Trainers, Shelby Mitchell

Occupational Therapy Doctorate Capstone Posters

In this ALE experience, I sought to bridge the existing gaps in research pertaining to most effective approaches and methodologies for rehabilitation in an adult day treatment setting, specifically in those with a traumatic brain injury. Fragmented and variable care compounded by poor communication are barriers to rehabilitation. However, it was also noted that traumatic brain injury survivors' long-term recovery was positively impacted by joining a peer network such as NeuroRestorative. Following this analysis, a needs assessment was conducted on-site at NeuroRestorative in Lexington, KY to enable more smooth daily programming and cohesive planning with life skills trainers. Goals included …


Accessible Shores: Promoting Beach Accessibility In Florida, Sara Swartz Jan 2024

Accessible Shores: Promoting Beach Accessibility In Florida, Sara Swartz

Occupational Therapy Doctorate Capstone Posters

This research experience sought to improve beach accessibility for members of the community facing barriers to occupational participation. Beach accessibility is essential for creating meaningful experiences and improving well-being through exposure to blue spaces. Despite its benefits, numerous environmental and systemic barriers hinder individuals with disabilities from safely accessing spaces. To further research this issue and challenges to participation, survey responses from community members of Jacksonville, Florida were gathered and analyzed for common themes. Conversations with professionals in the area allowed for greater insight on available resources and assistive device technology that could improve beach accessibility. To showcase this information …


Health Consequences Of Racial Disparity In Access To Abortion: A Systematic Review, Lacy M. Frye, Calvin Odhiambo Jan 2024

Health Consequences Of Racial Disparity In Access To Abortion: A Systematic Review, Lacy M. Frye, Calvin Odhiambo

University of South Carolina Upstate Student Research Journal

Prior to the 2022 Dobbs decision, Black women already experienced negative maternal health outcomes at an alarmingly disparate rate in comparison to White women. Given that the Dobbs decision emboldens state power to enforce abortion restrictions or protections, there has been significant strides made in both directions. Nonetheless, within states where reproductive rights have been significantly eroded, the heightened abortion restrictions may compound the limited access that Black women previously had before Dobbs. This, in turn will exacerbate the already disparate negative maternal outcomes that Black women experience. However, research on the relationship between the lack of access to abortion …


Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane Jan 2024

Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane

Turkish Journal of Medical Sciences

Bacground/Aim: The MSKCC(Memorial Sloan Kettering Cancer Center) nomogram was developed to predict survivorship in gastric cancer patients undergoing R0 resection. This study aimed to evaluate the predictive power of this nomogram in the Turkish patient population. Materials and Methods: Gastric cancer patients over 18 years of age who were admitted to our clinic between 2000 and 2019 and underwent primary curative surgery and R0 resection were included in the study. The 5-year and 9-year overall survival rates of 489 patients were analyzed. Real-life survival rates and those calculated with the MSKCC tool were compared in all patients and subgroups. The …


Reliability And Validity Of The Turkish Version Of The Infant Motor Activity Log In Infants With Upper Extremity Functional Asymmetry: How Often And How Well?, Kübra Seyhan Biyik, Cemi̇l Özal, Kivanç Deli̇oğlu, Mi̇ntaza Kerem Günel Jan 2024

Reliability And Validity Of The Turkish Version Of The Infant Motor Activity Log In Infants With Upper Extremity Functional Asymmetry: How Often And How Well?, Kübra Seyhan Biyik, Cemi̇l Özal, Kivanç Deli̇oğlu, Mi̇ntaza Kerem Günel

Turkish Journal of Medical Sciences

Background/aim: Functional asymmetry in the upper extremities may occur in infants with neuromotor problems due to neurodevelopmental or musculoskeletal disorders. The aim of this study was to investigate the validity and reliability of the Turkish version of the Infant Motor Activity Log Scale (IMAL-T), which asks about the frequency (how often) and quality (how well) of the affected arm usage during activities in infants with functional asymmetry in the upper extremities.Materials and methods: The IMAL-T was administered face-to-face to parents of 102 infants (60 infants at high risk of cerebral palsy (CP) and 42 infants with brachial plexus birth injury …


Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir Jan 2024

Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir

Turkish Journal of Medical Sciences

Background/aim: Innate-like T lymphocytes are a recently defined group of T cells comprising mainly mucosa-associated invariant T (MAIT) cells. The relationship between MAIT cells and childhood asthma is controversial. In this study, we aimed to determine the role of MAIT cells in patients with allergic asthma (AA) and nonallergic asthma (NAA). This is the first study to compare the ratios of these cells in patients with AA and NAA.Materials and methods: The study included children aged 6–18 years with AA (n = 41) or NAA (n = 30) and healthy control subjects (n = 36). The control group consisted of …


Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin Jan 2024

Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin

Turkish Journal of Medical Sciences

Background/aim: The p53 protein, a crucial tumor suppressor, governs cell cycle regulation and apoptosis. Similarly, p63, a member of the p53 family, exhibits traits of both tumor suppression and oncogenic behavior through its isoforms. However, the functional impact of ΔNp63β, an isoform of the p63 protein, on human glioma cancer cells like T98G cells remains poorly understood, representing the novelty of this study in the current literature.Materials, methods: Employing the pRetroX-Tet-On vector system, we investigated ΔNp63β's apoptotic effects on T98G cell lines and assessed its influence on the cell cycle. Initially, we established a rtTA-expressing vector, a component of the …


Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar Jan 2024

Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar

Turkish Journal of Medical Sciences

Background/aimLung cancer, a predominant contributor to cancer mortality, is characterized by diverse etiological factors, including tobacco smoking and genetic susceptibilities. Despite advancements, particularly in non-small cell carcinoma (NSCC), therapeutic options for squamous cell carcinoma (LUSC) are limited. Transposable elements (TE) and their regulatory proteins, such as Transposable element derived (TIGD) family proteins, have been implicated in cancer development. TIGD1, upregulated in various cancers, including LUSC, lacks a defined function. This study aimed to elucidate the biological functions, associated pathways, and interacting proteins of TIGD1.Materials and methodsThe GSE229260 microarray dataset were investigated using GEO2R tool to identify the differentially expressed genes …


In Silico Study Of Bioactive Compounds Derived From Indonesian Marine Invertebrates As Novel Antituberculosis Agent, Ayu Masyita, Eri̇s Septiana, Asep Bayu, Bustanussalam Bustanussalam, Jonathan A. Panggabean, Fi̇rdayani̇ Firdayani, Tuti̇k Murniasih Jan 2024

In Silico Study Of Bioactive Compounds Derived From Indonesian Marine Invertebrates As Novel Antituberculosis Agent, Ayu Masyita, Eri̇s Septiana, Asep Bayu, Bustanussalam Bustanussalam, Jonathan A. Panggabean, Fi̇rdayani̇ Firdayani, Tuti̇k Murniasih

Turkish Journal of Medical Sciences

Background/aim: Tuberculosis has still become the most deadly disease globally. The problem of finding an effective therapeutic is one of the obstacles in the treatment of patients. Marine invertebrates were a treasure since they produced many active compounds. Following up on this issue, screening active compounds is very important. This study will explain the result of anti-tuberculosis screening of compounds derived from marine invertebrates using in silico and confirmed to the in vitro-data.Materials and methods: Three-dimensional (3D) structures of pantothenate kinase (MtPanK type 1, PDB ID: 4BFT), Mycobacterium tuberculosis InhA (MtInhA, PDB ID: 2X23), protein kinase B (PDB ID: 5U94), …


The Role Of Circadian Rhythm Proteins Rev-Erb Α/ And Β In The Development Of Neuronal Injury After Taumatic Brain Injury, Mahmud Pençe, Enes Dogan, Hali̇l Koç, Ci̇gdem Bayraktaroglu, Serdar Altunay, Zeynep Balçikanli, Ertugrul Kiliç, Mustafa Beker Jan 2024

The Role Of Circadian Rhythm Proteins Rev-Erb Α/ And Β In The Development Of Neuronal Injury After Taumatic Brain Injury, Mahmud Pençe, Enes Dogan, Hali̇l Koç, Ci̇gdem Bayraktaroglu, Serdar Altunay, Zeynep Balçikanli, Ertugrul Kiliç, Mustafa Beker

Turkish Journal of Medical Sciences

Background/Aim:Circadian rhythm proteins (CRP) play critical roles in both physiological and pathophysiological conditions, including neurodegenerative disorders. As member of CRP, the nuclear receptors REV-ERBα/β regulates circadian rhythm particularly by inhibiting Bmal1 protein and involved in the neuroinflammation- and cell death processes. However, their roles in the development of neuronal injury after traumatic brain injury (TBI) were largely unexplored, which were investigated in the present study.Materials and Methods: For the induction of TBI, animals were submitted to the cryogenic model of TBI, which is a commonly used animal model and shares essential similarities with cerebral ischemia in terms of pathophysiological cascades. …


Epidemiology Of Heart Failure In Türkiye, Nai̇m Ata, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Şuayi̇p Bi̇ri̇nci̇, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Di̇lek Ural, Lale Di̇nç Asarcikli, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Ahmet Çeli̇k Jan 2024

Epidemiology Of Heart Failure In Türkiye, Nai̇m Ata, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Şuayi̇p Bi̇ri̇nci̇, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Di̇lek Ural, Lale Di̇nç Asarcikli, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Ahmet Çeli̇k

Turkish Journal of Medical Sciences

Background/aim:The epidemiological data on heart failure (HF) vary between regions within the same country.We aimed to investigate the epidemiological data on HF in Turkiye across all age groups regarding seven geographical regions.Materials and methods:We included all patients in the Turkish population with a first diagnosis of HF between January 1, 2016 and December, 31 2022, with the use of ICD-10 codes from the National Electronic Healthcare Database.The data were categorized by seven geographical regions of Turkiye.Results:The median age of index diagnosis of HF was 70(60-78) years in all age groups and 4(1-12) years in pediatric population.Prevalence rate of HF was …


Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik Jan 2024

Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik

Turkish Journal of Medical Sciences

Background/aim:Randomized controlled trials usually lack generabilizity to real-world context.Real-world data, enabled by the use of big data analysis, serve as a connection between the results of trials and the implementation of findings in clinical practice.Nevertheless, using big data in the healthcare has difficulties such as ensuring data quality and consistency.This article aimed to examine the challenges in accessing and utilizing healthcare big data for heart failure (HF) research, drawing from experiences in creating a nationwide HF registry in Turkiye.Materials and methods:We established a team including cardiologists, HF specialists, biostatistics experts, and data analysts. We searched certain key words related to …


Diagnostic Approach To Heart Failure In Türkiye, Di̇lek Ural, Lale Di̇nç Asarcikli, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Yüksel Çavuşoğlu, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Selda Murat, Emre Demi̇r, Emi̇ne Arzu Kanik, Ahmet Çeli̇k Jan 2024

Diagnostic Approach To Heart Failure In Türkiye, Di̇lek Ural, Lale Di̇nç Asarcikli, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Yüksel Çavuşoğlu, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Selda Murat, Emre Demi̇r, Emi̇ne Arzu Kanik, Ahmet Çeli̇k

Turkish Journal of Medical Sciences

Background/aim:Final diagnosis of heart failure (HF) relies on a combination clinical findings, laboratory and imaging tests.The aim of this study was to review the diagnostic approach to HF in Turkiye.Materials and methods:This study is a subanalysis of the nationwide TRends-HF study based on anonymized data of National Electronic Database between January 1, 2016, and December 31, 2022.Variables including date of birth, sex, socioeconomic development index, place of initial HF diagnosis, comorbidities, investigations, and diagnostic procedures were reported.Laboratory variables, including complete blood count, natriuretic peptides (NP), estimated glomerular filtration rate, uric acid, electrolytes, albumin, lipid profile, ferritin and hemoglobin A1c levels …


Burden Of Comorbidities In Heart Failure Patients In Türkiye, Yüksel Çavuşoğlu, Selda Murat, Anil Şahi̇n, İnci̇ Tuğçe Çöllüoğlu, Di̇lek Ural, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Emre Demi̇r, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Ahmet Çeli̇k Jan 2024

Burden Of Comorbidities In Heart Failure Patients In Türkiye, Yüksel Çavuşoğlu, Selda Murat, Anil Şahi̇n, İnci̇ Tuğçe Çöllüoğlu, Di̇lek Ural, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Emre Demi̇r, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Ahmet Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: Heart Failure (HF) is associated with a wide range of comorbidities that negatively impact on clinical outcomes and cause to high economic burden. We aimed to evaluate frequency and burden of comorbidities in HF patients in Türkiye and their relationship with the patient's demographic characteristics.Materials and methods: Based on ICD-10 codes in National Electronic Database of the Turkish Ministry of Health, covering the entire population of Türkiye (n=85,279,553), from January 1, 2016, to December 31, 2022, prevalence of comorbidities in HF patients were obtained. Frequency and burden of comorbidities were analyzed separately by age groups, gender and socioeconomic status …


Determination Of The Embryotoxic Effects Of Propofol Injected Into Eggs On The Cerebellum And Spinal Cord Using Histologic Methods: An Animal Study, Murat İzgi̇, Emrah Sur Jan 2024

Determination Of The Embryotoxic Effects Of Propofol Injected Into Eggs On The Cerebellum And Spinal Cord Using Histologic Methods: An Animal Study, Murat İzgi̇, Emrah Sur

Turkish Journal of Medical Sciences

This study aims to determine the possible embryotoxic effects of propofol on the cerebellum and spinal cord using fertile chicken eggs. Materials and methods: A total of 430 fertile eggs were divided into 5 groups: control, saline, 2.5 mg.kg–1, 12.5 mg.kg–1, and 37.5 mg.kg–1 propofol. Injections were made immediately before incubation via the air chamber. On the 15th, 18th, and 21st day of incubation, 6 embryos from each group were evaluated. Serial paraffin sections taken from the cerebellum and spinal cord were stained with hematoxylin–eosin, Kluver–Barrera, toluidine blue, and periodic acid-Schiff ’s reaction. The outer granular layer and total cortex …


Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan Jan 2024

Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan

Turkish Journal of Medical Sciences

Chemical biological radiological nuclear threats are at an important point in the agenda of world health today, as theycan cause mass deaths. B. mallei attracts attention as a potential biological warfare agent due to its features such as multidrug resistance,a rapid transmission mechanism via aerosol, the absence of a complete treatment protocol for the infection it causes, and the absence ofan approved vaccine for protection against the bacteria. B. mallei suspect samples must be studied by experienced personnel in biosafetylevel III laboratories. B mallei is a difficult and troublesome pathogen to diagnose and many unknowns about B. mallei today. Therefore,the …


Evaluation Of Eye And Serum Findings In Different Waters In Rabbits By Drowning And Submersion Modeling, Aziz Yilmaz, Erdem Hösükler, Abdulgani Kaymaz, Ahmet Yücel Üçgül, Zehra Zerrin Erkol Jan 2024

Evaluation Of Eye And Serum Findings In Different Waters In Rabbits By Drowning And Submersion Modeling, Aziz Yilmaz, Erdem Hösükler, Abdulgani Kaymaz, Ahmet Yücel Üçgül, Zehra Zerrin Erkol

Turkish Journal of Medical Sciences

This study investigated serum, vitreous, and anterior chamber fluid electrolyte changes, corneal thickness (CT),corneal volume (CV), anterior chamber volume (ACV), and anterior chamber depth (ACD) as an auxiliary diagnostic method in theidentification of drowning in fresh or salt water.Materials and methods: The study used 35 healthy, adult, male, white New Zealand rabbits, seperated into five groups (control, saltwaterdrowning (SWD), saltwater immersion (SWI), freshwater drowning (FWD), freshwater immersion (FWI)). CT, CV, ACV, and ACDmeasurements were made with Pentacam topography at 0, 2, and 4 h in all groups. Magnesium (mg), sodium (Na), and chlorine (Cl)were measured in the blood at 0 …


Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan Jan 2024

Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan

Turkish Journal of Medical Sciences

Traumatic spinal cord injury (TSCI) is an important health problem, especially in developing countries withadditional socioeconomic loss. Humic acid (HA) usually has antioxidant, antiinflammatory, blood circulating, and antiviral effects.Hence, it was aimed herein to show the effect of HA on neuroprotection in a TSCI model.Materials and method: A TSCI model was used, in which 24 Wistar albino rats were divided into 4 groups: control group: subjectedto only laminectomy; sham group: subjected to laminectomy + TSCI; HA 5 mg/kg group: subjected to laminectomy + TSCI +intraperitoneal (IP) injection of 5 mg/kg of HA; and HA 10 mg/kg group: subjected to laminectomy …


Effects Of Glutamine And Omega-3 Fatty Acids On Intestinal Neomucosa Formation On Colon Serosa In Rats, Mehmet Köstek, Uygar Demi̇r, Ramazan Uçak, Burak Yasin Avci, Aydın Ünal, Osman Bilgin Gülçi̇çek, Ozan Çalişkan, Bülent Çi̇tgez, Erdinç Seri̇n, Sıtkı Gürkan Yetki̇n, Mehmet Mi̇hmanli, Mehmet Uludağ Jan 2024

Effects Of Glutamine And Omega-3 Fatty Acids On Intestinal Neomucosa Formation On Colon Serosa In Rats, Mehmet Köstek, Uygar Demi̇r, Ramazan Uçak, Burak Yasin Avci, Aydın Ünal, Osman Bilgin Gülçi̇çek, Ozan Çalişkan, Bülent Çi̇tgez, Erdinç Seri̇n, Sıtkı Gürkan Yetki̇n, Mehmet Mi̇hmanli, Mehmet Uludağ

Turkish Journal of Medical Sciences

Intestinal neomucosa formation is a technique defined for the treatment of short bowel syndrome. This study evaluates the effect of glutamine and omega-3 fatty acids on the growth of intestinal neomucosa on the colonic serosal surface has been evaluated.Materials and methods: Thirty-two adult male Sprague-Dawley rats were randomly divided into 4 groups: sham, control, glutamine, and omega-3. Laparotomy was performed on all groups. For rats other than the sham group, a 1-cm full-thickness incision was made 4 cm proximal to the ileocecal valve, and colonic serosal surface was sutured as a serosal patch over these openings. By using the oral …


Evaluation Of Baseline F-18 Fdg Positron Emission Tomography In The Diagnosis And Assessment Of Giant Cell Arteritis, Burak İnce, Emine Göknur Işik, Zeynep Gözde Özkan, Yasemin Yalçinkaya, Bahar Artım Esen, Ahmet Gül, Murat İnanç Jan 2024

Evaluation Of Baseline F-18 Fdg Positron Emission Tomography In The Diagnosis And Assessment Of Giant Cell Arteritis, Burak İnce, Emine Göknur Işik, Zeynep Gözde Özkan, Yasemin Yalçinkaya, Bahar Artım Esen, Ahmet Gül, Murat İnanç

Turkish Journal of Medical Sciences

The aim of this study is to evaluate the baseline F18-FDG PET/CT findings of individuals diagnosed with giant cellarteritis (GCA) and to explore its association with clinical findings and classification criteria.Materials and methods: We analysed data from patients who underwent F18-FDG PET/CT scans to investigate large vessel (LV)involvement between 2010 and 2019. Only patients with a clinical diagnosis of GCA and at least 6 months of follow-up were included.We compared initial clinical features and laboratory findings based on the presence of LV vasculitis on PET/CT and the maximumstandard uptake value (SUVmax) of vascular territories.Results: Twenty-nine patients (median age at diagnosis: …


Does The Pleth Variability Index Have Any Predictive Value For Intraoperative Respiratory Problems In Bariatric Surgery?, Esra Özayar, Mehmet Şahap, Handan Güleç, Aysun Kurtay, Adem Selvi̇, Hakan Buluş, Özlem Ari Jan 2024

Does The Pleth Variability Index Have Any Predictive Value For Intraoperative Respiratory Problems In Bariatric Surgery?, Esra Özayar, Mehmet Şahap, Handan Güleç, Aysun Kurtay, Adem Selvi̇, Hakan Buluş, Özlem Ari

Turkish Journal of Medical Sciences

We aimed to search the relationship between the preoperative PVI (pleth variability index) and intraoperative respiratory parameters to reveal whether PVI can be used as a prediction tool in bariatric surgery.Materials and methods: Forty patients undergoing bariatric surgery were included. Noninvasive pleth variability index measured via finger probe before induction of general anesthesia. Following intubation each patient was ventilated in controlled mode. Intraoperative blood pressure, peak airway pressure, end-tidal CO2, SpO2, PEEP, and FiO2 were recorded every 5 min for the first 10 min and then every 10 min until extubation. Steroid and bronchodilator requirements were recorded.Results: The systolic pressure-PVI, …


The Effect Of Erector Spinae Plane Block On Postoperative Extubation Time And Laboratory Parameters In Open Heart Surgery: A Retrospective Study, Feyza Çalişir, Yavuz Orak, Ömer Faruk Boran, Metin Ege, Mehmet Emin Karabeki̇roğlu, Hilal Bi̇radli, Adem Doğaner Jan 2024

The Effect Of Erector Spinae Plane Block On Postoperative Extubation Time And Laboratory Parameters In Open Heart Surgery: A Retrospective Study, Feyza Çalişir, Yavuz Orak, Ömer Faruk Boran, Metin Ege, Mehmet Emin Karabeki̇roğlu, Hilal Bi̇radli, Adem Doğaner

Turkish Journal of Medical Sciences

In open heart surgery, sternotomy causes inflammation in tissues, and inflammation causes postoperative pain. This study aims to examine the effects of bilateral erector spinae plane (ESP) blocks on postoperative extubation time and laboratory parameters in open heart surgery.Materials and methods: The study was managed using retrospective data from 85 patients who underwent open-heart surgery. Patients who received intravenous analgesia and were transferred to the intensive care unit with intubation were included in the study. Two groups were formed: those who received preoperative bilateral ESP block (ESB) and those nonblock (NB). Statistical significance was investigated between ESB and NB in …


Survival Benefit Of Resin Cartridge Extracorporeal Blood Purification Therapy In Patients With Septic Shock, Serdar Efe, Pervin Hanci, Volkan İnal Jan 2024

Survival Benefit Of Resin Cartridge Extracorporeal Blood Purification Therapy In Patients With Septic Shock, Serdar Efe, Pervin Hanci, Volkan İnal

Turkish Journal of Medical Sciences

Extracorporeal blood purification (EBP) therapies have shown promise as potential rescue treatments for patientswith septic shock. However, precise evidence regarding their effectiveness is lacking. This case-control study aimed to evaluate the 28-day survival benefit of a resin cartridge-based EBP therapy compared to conventional therapies in patients with septic shock.Materials and methods: The study sample was collected retrospectively from the medical records of patients admitted to the intensivecare unit (ICU) between 2015 and 2020. The study included patients with septic shock aged ≥18 years who had ICU stays >96 h andexcluded those lost to follow-up by 28 days or readmitted. First, …


Reliability And Validity Of New Isokinetic Strength Assessment For Rotator Cuff Muscles In A Muscle Architecture-Based Position, Çağlar Soylu, Mustafa Ertuğrul Yaşa, Pervin Demi̇r, Ahmet Mustafa Ada, Tüzün Firat, Necmiye Ün Yildirim Jan 2024

Reliability And Validity Of New Isokinetic Strength Assessment For Rotator Cuff Muscles In A Muscle Architecture-Based Position, Çağlar Soylu, Mustafa Ertuğrul Yaşa, Pervin Demi̇r, Ahmet Mustafa Ada, Tüzün Firat, Necmiye Ün Yildirim

Turkish Journal of Medical Sciences

Isokinetic strength assessment of the rotator cuff muscle is frequently applied in a variety of shoulder postures, butnone of these consider muscular architecture, which is one of the most important aspects of improving strength development. This studyaimed to examine the test and retest reliability and validity of the muscle architecture-based position (MABP), which is 25° abductionand 20° external rotation, in healthy subjects to be able to select a better isokinetic assessment position for shoulder rotator cuff muscles.Materials and methods: A total of 54 healthy males with a mean age of 21.0 ± 1.2 years and mean body mass index of …


The Effect Of Video-Assisted Training On Upper Extremity Problems And Functions After Rotator Cuff Repair: A Randomized Controlled Trial, Canan Kanat, Gülay Altun Uğraş, Recep Ünal, Servet Can Dönmez, Bahar Taşdelen, Fehmi Volkan Öztuna Jan 2024

The Effect Of Video-Assisted Training On Upper Extremity Problems And Functions After Rotator Cuff Repair: A Randomized Controlled Trial, Canan Kanat, Gülay Altun Uğraş, Recep Ünal, Servet Can Dönmez, Bahar Taşdelen, Fehmi Volkan Öztuna

Turkish Journal of Medical Sciences

The shoulder is the most mobile joint in the body, and is frequently exposed to injuries. The applied surgical treatments, protection of the shoulder after surgery, care in the use of the shoulder in activities of daily living (ADLs) and gradual exercise programs are all vital to the recovery process. The present study investigates the effect of video-assisted training (VAT) on upper extremity complications and functions after rotator cuff repair (RCR).Materials and method: Included in this prospective, parallel two-armed, randomized controlled study were an experimental group (n: 24) that received VAT detailing early postoperative care for RCR and instructions on …


Urologists’ Opinion On Treating Asymptomatic Stones: Would We Treat Ourselves As We Treat Our Patients? Survey From European Association Of Urology, Young Academicurologists, Endourology And Urolithiasis Working Party, Tarık Emre Şener, Thomas Tailly, Yılören Tanidir, Etienne Xavier Keller, Amelia Pietropaolo, Juan Gomez Rivas, Zeeshan Hameed, Vincent De Coninck, Tzevat Tefi̇k, Kemal Sarica, Ali Serdar Gözen, Andreas Skolarikos, Olivier Traxer, Christian Seitz, Bhaskar Somani Jan 2024

Urologists’ Opinion On Treating Asymptomatic Stones: Would We Treat Ourselves As We Treat Our Patients? Survey From European Association Of Urology, Young Academicurologists, Endourology And Urolithiasis Working Party, Tarık Emre Şener, Thomas Tailly, Yılören Tanidir, Etienne Xavier Keller, Amelia Pietropaolo, Juan Gomez Rivas, Zeeshan Hameed, Vincent De Coninck, Tzevat Tefi̇k, Kemal Sarica, Ali Serdar Gözen, Andreas Skolarikos, Olivier Traxer, Christian Seitz, Bhaskar Somani

Turkish Journal of Medical Sciences

Management of asymptomatic kidney stones is an ongoing debate with follow-up and treatment guidelines based on low-level evidence. Our aim was to evaluate current management of asymptomatic urinary stones.Materials and methods: A 70-question survey was designed in collaboration with European Association of Urology, Young Academic Urologists, Section of Uro-Technology and Section of Urolithiasis groups and distributed. Responders filled out hypothetical scenarios from 2 perspectives, either as treating physicians, or as patients themselves.Results: A total of 212 (40.01%) responses were obtained. Median responder age was 39 years. 75% of responders were interested in “urolithiasis”. 82.5% had never experienced a renal colic, …