Medicine and Health Sciences Commons^™

First-Line Chemoimmunotherapy And Immunotherapy In Patients With Non-Small Cell Lung Cancer And Brain Metastases: A Registry Study, Lauren J. Brown, Victor Khou, Chris Brown, Marliese Alexander, Dasantha Jayamanne, Joe Wei, Lauren Gray, Wei Chan, Samuel Smith, Susan Harden, Antony Mersiades, Lydia Warburton, Malinda Itchins, Jenny H. Lee, Nick Pavlakis, Stephen J. Clarke, Michael Boyer, Adnan Nagrial, Eric Hau, Ines Pires Da Silva, Steven Kao, Benjamin Y. Kong

Research outputs 2022 to 2026

Introduction: Brain metastases commonly occur in patients with non-small cell lung cancer (NSCLC). Standard first-line treatment for NSCLC, without an EGFR, ALK or ROS1 mutation, is either chemoimmunotherapy or anti-PD-1 monotherapy. Traditionally, patients with symptomatic or untreated brain metastases were excluded from the pivotal clinical trials that established first-line treatment recommendations. The intracranial effectiveness of these treatment protocols has only recently been elucidated in small-scale prospective trials. Methods: Patients with NSCLC and brain metastases, treated with first-line chemoimmunotherapy or anti-PD-1 monotherapy were selected from the Australian Registry and biObank of thoracic cancers (AURORA) clinical database covering seven institutions. The primary …

Source-Specific Nitrate And Nitrite Intakes And Associations With Sociodemographic Factors In The Danish Diet Cancer And Health Cohort, Dorit W. Erichsen, Pratik Pokharel, Cecilie Kyrø, Jörg Schullehner, Liezhou Zhong, Catherine P. Bondonno, Frederik Dalgaard, Peter Hendriksen, Torben Sigsgaard, Jonathan M. Hodgson, Anja Olsen, Anne Tjønneland, Nicola P. Bondonno

Research outputs 2022 to 2026

Background: The dietary source and intake levels of nitrate and nitrite may govern its deleterious versus beneficial effects on human health. Existing evidence on detailed source-specific intake is limited. The objectives of this study were to assess nitrate and nitrite intakes from different dietary sources (plant-based foods, animal-based foods, and water), characterize the background diets of participants with low and high intakes, and investigate how sociodemographic and lifestyle factors associate with intake levels. Methods: In the Danish Diet, Cancer and Health Cohort, sociodemographic and lifestyle information was obtained from participants at enrolment (1993–1997). Source-dependent nitrate and nitrite intakes were calculated …

Barriers And Enablers To A Healthy Food Environment In Australian Childcare Services: Exploring Directors' Perspectives, Amy Kirkegaard, Chris Irwin, Rebecca Byrne, Ros Sambell, Lisa Vincze

Research outputs 2022 to 2026

Issue Addressed: Early childhood education and care (ECEC) settings are ideal environments to optimise nutrition and positively influence children's food behaviours. However, recent research has identified the need to improve nutrition policies, food provision, and mealtime environments in Australian ECEC settings. This study explored the perceptions of ECEC directors regarding barriers and enablers to a health-promoting food environment within ECEC services. Methods: Eleven directors from ECEC services in Nerang, Queensland, and surrounding areas, participated in qualitative interviews between March and May 2021. Transcripts were analysed using qualitative content analysis that followed a deductive-inductive approach employing nutrition-related domains from the Wellness …

What Are The Experiences Of Supportive Care In People Affected By Brain Cancer And Their Informal Caregivers: A Qualitative Systematic Review, C. Paterson, C. Roberts, J. Li, M. Chapman, Karen Strickland, N. Johnston, E. Law, R. Bacon, M. Turner, I. Mohanty, G. Pranavan, K. Toohey

Research outputs 2022 to 2026

Purpose: To critically synthesise qualitative research to understand experiences of supportive care in people affected by brain cancer and their informal caregivers. Methods: A qualitative systematic review was conducted according to the Joanna Briggs methodology and has been reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines. Electronic databases were searched by an expert systematic review librarian for all qualitative studies irrespective of research design. All publications were double screened by two reviewers using a pre-determined exclusion and inclusion criteria. The review was managed using Covidence systematic review software. Methodological quality assessment and data extraction …

Effects Of Physical Exercise On Academic Performance In University Students: A Systematic Review, Yury Rosales-Ricardo, Verónica Cáceres-Manzano

Health Professions Education

Purpose: to evaluate the scientific evidence on the effects of physical exercise on the academic performance of university students, through a systematic review.

Methods: Eleven hundred and fifty-three studies emerged from this search, based on the following selection criteria: articles published in the last 5 years, original studies of different types: experimental at any level, correlational, analytical, and observational, where any type of physical exercise is applied, in undergraduate university students, of any sex and university career. The review was finally performed with only 11 studies. Search for appropriate manuscripts was based on the following descriptive terms: "Exercise" …

Project-Based Learning And Student Outcomes In Health Professions Education: A Literature Review, Melanie Aley, Regina Lee, Jordana Wang, Joy Wang, Sophia Zheng

Health Professions Education

Purpose. Project-based learning (PjBL) is an instructional method designed to help students cultivate skills transferable beyond traditional education systems focused on didactic learning. This literature review aims to critically summarise existing literature on PjBL and its value in tertiary health professions curricula, especially with regards to cognitive, affective and behavioral student outcomes. In doing so, this study seeks to inform teaching and learning approaches that nurture skills desirable in professional settings.

Method. An electronic search for relevant English journal articles was conducted using four databases; EBSCOhost, Medline, Web of Science and Scopus. Studies which pre-date 2012, fail to …

Environmental Sustainability, Healthcare Workers And Healthcare Students: A Literature Review Of Attitudes And Learning Approaches, Pamela R. Mccauley, Kavita Mathur, Reza Kamali Miab, Nina Cohen, Kedena Henriques-Thompson, Jyo Gopinath

Health Professions Education

Purpose: Today, increased attention has been placed on the healthcare industry and its workers in the wake of the global COVID-19 pandemic. Increases in facemask production, personal protective equipment, and the number of patients admitted into hospitals have resulted in a sharp rise in medical waste and environmental concerns. This has led to a greater interest by the research community to study the type of training and education that healthcare workers and students receive which could facilitate the implementation of sustainability activities during their work.

Design/Methodology: We have conducted a literature review (2010 to 2024) on healthcare worker …

Empathy Development Among Undergraduate Health Professions’ Students Serving As Caregivers To Hospice Patients, Kelly Melekis, Carol S. Weisse, Emma Phillips, Claire Slattery

Health Professions Education

Although empathy is considered a core competency for healthcare providers and has been shown to play an important role in improving patient outcomes, empathy development while working with dying patients is not well understood and may present challenges during clinical training. This qualitative study explored empathy development among 24 undergraduate health professions students participating in an experiential training program where they served as caregivers providing bedside care to hospice patients. An exploratory case study design was used to assess empathy development as expressed via responses to a series of questions and vignettes prior to and upon completion of the training …

Digital Storytelling As An Innovative Approach To Prehospital Education: The Experiences Of Teaching Academics., Andrew Van Noordenburg, Georgina Seaman

Health Professions Education

Purpose. To explore teaching academics' experiences of utilising digital storytelling as an innovative approach to prehospital education.

Method. This study describes an innovative learning activity, digital storytelling, developed for an undergraduate paramedicine program. The experiences of teaching academics were then explored through semi-structured interviews. Thematic analysis was used to evaluate the data.

Results. Three themes were identified through thematic analysis. The first theme was ‘the impact of friction on learning’ which describes how a learning activity’s design can negatively impact learning. The second theme ‘connecting with the teaching resources’ outlines how having access to sufficient resources is necessary to facilitate …

Improving Medical Education Of Risks Of Ai Use In Healthcare, Stephanie Quon, Catherine Ha

Health Professions Education

Artificial intelligence (AI) offers transformative potential in healthcare, enhancing drug discovery, data processing, early detection, and clinical decision-making. However, its adoption poses significant risks, including client harm, misuse, automation bias, perpetuation of inequities, and security issues. Effective integration requires ongoing collaboration among healthcare professionals, developers, policymakers, and ethicists to ensure accountability and transparency. As AI becomes more prevalent, medical education must evolve to equip students with a deep understanding of AI technology, risk assessment, and mitigation strategies. Currently, medical curricula fall short in this area, necessitating educational reforms. We propose diverse and comprehensive teaching methods, including case studies, interdisciplinary projects, …

Measuring Awareness, Empowerment And Action Orientation: Validation Of The Health Professions Educators Diversity, Equity, And Inclusion Scale (Hpe Dei, Peggy Gesing, R. Jason Lynch, Amanda K. Burbage

Health Professions Education

Purpose. Educating students in health occupations about diversity, equity, and inclusion (DEI) can improve healthcare outcomes for the clients they serve, yet educators may lack training and readiness for incorporating DEI in course content. The purpose of this study was to develop and validate the psychometric properties of the Health Professions Educators DEI Scale (HPE DEI), which measures awareness, empowerment, and action orientation of educators.

Method. A 19-item literature-informed intrument was developed and reviewed for content validity by subject matter experts. Convenience and snowball sampling were used. The piloted instrument was distributed to seven institutions and received sufficient responses for …

Twin Scholarships Of Glycomedicine And Precision Medicine In Times Of Single-Cell Multiomics, Seungyoul Oh, Weijie Cao, Manshu Song

Research outputs 2022 to 2026

Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions. Systems biology technologies have enabled large-scale and high-throughput glycoprofiling and access to data-intensive biological repositories for global research. These advancements have established glycans as a pivotal third code of life, alongside nucleic acids and amino acids. However, challenges …

A Comprehensive Multi-Omics Analysis Reveals Unique Signatures To Predict Alzheimer’S Disease, Michael Vacher, Rodrigo Canovas, Simon M. Laws, James D. Doecke

Research outputs 2022 to 2026

Background: Complex disorders, such as Alzheimer’s disease (AD), result from the combined influence of multiple biological and environmental factors. The integration of high-throughput data from multiple omics platforms can provide system overviews, improving our understanding of complex biological processes underlying human disease. In this study, integrated data from four omics platforms were used to characterise biological signatures of AD. Method: The study cohort consists of 455 participants (Control:148, Cases:307) from the Religious Orders Study and Memory and Aging Project (ROSMAP). Genotype (SNP), methylation (CpG), RNA and proteomics data were collected, quality-controlled and pre-processed (SNP = 130; CpG = 83; RNA …

Impact On Help-Seeking Behaviours Of A Campaign Perceived To Decrease Stigma And Increase Openness Around Mental Health, Robert J. Donovan, Catherine F. Drane, Ziggi I. Santini, Geoffrey Jalleh

Research outputs 2022 to 2026

Issue Addressed: There is considerable evidence that public stigma around mental illness inhibits help-seeking for mental health problems. Hence there have been many interventions and campaigns designed to reduce stigma around mental illness. However, as far as could be ascertained, none of these stigma reduction interventions has reported any substantial impact of reducing stigma on people's mental health help-seeking behaviours. The aim of this paper is to report on the impact of the Act-Belong-Commit positive mental health promotion Campaign on help-seeking via increasing perceived openness around mental health and reducing perceived stigma around mental illness. Methods: State-wide computer assisted telephone …

Insights From A National Database For Programs Supporting Neuropsychiatric Symptoms Of Dementia In Australia, Mustafa Atee, Thomas Morris, Daniel Whiting, Stephen Macfarlane, Marie Alford

Research outputs 2022 to 2026

No abstract provided.

Psychedelic Trip Sitting, Dosages And Intensities: Supplementing Clinical Studies With Anecdotal Reports, Liam B. Engel, Sascha Thal, Stephen J. Bright, Mitchell Low

Research outputs 2022 to 2026

Background and aims: Online communities provide insights into psychedelic consumption, assisting in identification of trends, informing both harm reduction provisions and clinical research. This study extracts forum data on psychedelic substances, dosages, and administration routes, categorising and analysing self-reported consumption to inform care services and guide clinical work with psychedelics. Methods: Posts (n = 660) from online psychedelic forums (The Shroomery and DMT Nexus) on 'trip sitting' were analysed. Using a Delphi-style expert panel review facilitated by LE, we created drug weight and intensity charts (threshold, light, common, strong and heavy dosages) for psychedelics discussed in these posts. The psychedelic …

Seven-Day Dietary Nitrate Supplementation Clinically Significantly Improves Basal Macrovascular Function In Postmenopausal Women: A Randomized, Placebo-Controlled, Double-Blind, Crossover Clinical Trial, Jocelyn M. Delgado Spicuzza, Jigar Gosalia, Liezhou Zhong, Catherine Bondonno, Kristina S. Petersen, Mary Jane De Souza, Elmira Alipour, Daniel B. Kim-Shapiro, Yasina B. Somani, David N. Proctor

Research outputs 2022 to 2026

Introduction: Cardiovascular disease (CVD) is the leading cause of death in women, with increased risk following menopause. Dietary intake of beetroot juice and other plant-based nitrate-rich foods is a promising non-pharmacological strategy for increasing systemic nitric oxide and improving endothelial function in elderly populations. The purpose of this randomized, placebo-controlled, double-blind, crossover clinical trial was to determine the effects of short-term dietary nitrate (NO3−) supplementation, in the form of beetroot juice, on resting macrovascular endothelial function and endothelial resistance to whole-arm ischemia–reperfusion (IR) injury in postmenopausal women at two distinct stages of menopause. Methods: Early-postmenopausal [1–6 years following their final …

The Impact Of Mandated Use Early Warning System Tools On The Development Of Nurses' Higher-Order Thinking: A Systematic Review, Tracy Flenady, Justine Connor, Amy Louise Byrne, Deb Massey, Marie Danielle Le Lagadec

Research outputs 2022 to 2026

Aim: Ascertain the impact of mandated use of early warning systems (EWSs) on the development of registered nurses' higher-order thinking. Design: A systematic literature review was conducted, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and checklist (Page et al., 2021). Data Sources: CINAHL, Medline, Embase, PyscInfo. Review Methods: Eligible articles were quality appraised using the MMAT tool. Data extraction was conducted independently by four reviewers. Three investigators thematically analysed the data. Results: Our review found that EWSs can support or suppress the development of nurses' higher-order thinking. EWS supports the development of higher-order thinking in two …

The Influence Of Culture On The Health Beliefs And Health Behaviours Of Older Vietnam-Born Australians Living With Chronic Disease, Thi Ngoc Minh Nguyen, Rosemary Saunders, Gordana Dermody, Lisa Whitehead

Research outputs 2022 to 2026

Aim: To explore the health beliefs and health behaviours of older Vietnam-born people living with chronic disease in Western Australia. Design: This study was designed as a focused ethnography guided by the interpretative research paradigm and Leininger's Theory of Culture Care. Methods: Data were collected through participant observation and interviews undertaken at participants' homes in Western Australia over 7 months in 2019. Data were analysed using Wolcott's approach for transferring qualitative data, comprising three phases: description, thematic analysis and interpretation. Results: This study included 12 participants. The health perspectives and practices of older Vietnam-born Australians significantly reflected the traditional Vietnamese …

Using Image-Reflections To Support Undergraduate Students’ Relational Employability: A Practitioner Reflection, Ruth M. Wallace, Sally-Anne Doherty, Elizabeth Cook

Research outputs 2022 to 2026

This practitioner reflection explores our integration of the Relational Employability Framework within the Health Research Project capstone unit of a Bachelor of Health Science degree. To address the historically low quality of student reflections, we incorporated image-based reflective activities to improve engagement and depth. These activities encouraged students to use visual media to examine their developing relational employability. We developed and implemented a series of tutorial activities designed to scaffold this process, aiming to foster deeper reflective practice and highlight its importance for career development and employability. Our reflections indicate that, while grades did not significantly increase, students showed enhanced …

The Delta Concept Does Not Effectively Normalise Exercise Responses To Exhaustive Interval Training, Arthur Henrique Bossi, Wouter Timmerman, Diana Cole, Louis Passfield, James Hopker

Research outputs 2022 to 2026

Objectives: This study was designed to quantify inter- and intra-individual variability in performance, physiological, and perceptual responses to high-intensity interval training prescribed using the percentage of delta (%Δ) method, in which the gas exchange threshold and maximal oxygen uptake (V̇O2max) are taken into account to normalise relative exercise intensity. Design: Repeated-measures, within-subjects design with mixed-effects modelling. Methods: Eighteen male and four female cyclists (age: 36 ± 12 years, height: 178 ± 10 cm, body mass: 75.2 ± 13.7 kg, V̇O2max: 51.6 ± 5.3 ml·kg−1·min−1) undertook an incremental test to exhaustion to determine the gas exchange threshold and V̇O2max as prescription …

Preparing The Future Public Health Workforce: Fostering Global Citizenship Through The Relational Employability Framework - Insights From Two Case Studies, Elizabeth Cook, Sally-Anne Doherty, Ruth M. Wallace

Research outputs 2022 to 2026

A well-prepared public health workforce is essential for reducing disease burdens and improving population health, necessitating an education that addresses global and complex challenges. This paper explores the integration of the Relational Employability Framework in public health education as a tool to foster critical reflection and cultivate global citizenship among students and graduates. Global citizenship encompasses the social, political, environmental and economic actions of globally conscious individuals and communities, recognising that individuals operate within diverse local and global networks. Relational employability expands traditional notions of graduate employability, incorporating not only foundational career development and human interactions but also connections with …

Excitatory Drive To Spinal Motoneurones Is Necessary For Serotonin To Modulate Motoneurone Excitability Via 5-Ht2 Receptors In Humans, Tyler T. Henderson, Janet L. Taylor, Jacob R. Thorstensen, Justin J. Kavanagh

Research outputs 2022 to 2026

Serotonin modulates corticospinal excitability, motoneurone firing rates and contractile strength via 5-HT2 receptors. However, the effects of these receptors on cortical and motoneurone excitability during voluntary contractions have not been explored in humans. Therefore, the purpose of this study was to investigate how 5-HT2 antagonism affects corticospinal and motoneuronal excitability with and without descending drive to motoneurones. Twelve individuals (aged 24 ± 4 years) participated in a double-blind, placebo-controlled, crossover study, whereby the 5-HT2 antagonist cyproheptadine was administered. Transcranial magnetic stimulation (TMS) was delivered to the motor cortex to produce motor evoked potentials (MEPs), and electrical stimulation at the cervicomedullary …

Editorial: Neurotoxins In Alzheimer's Disease And Other Dementias, Alexandre Henriques, Philippe L. L. Poindron, Binosha Fernando, Kevin N. Hascup

Research outputs 2022 to 2026

Alzheimer's disease (AD) and other dementias are neurodegenerative disorders characterized by a progressive decline in cognition and independence from activities of daily living. Dementia is multifactorial with numerous risk factors including age, genes, molecules, lifestyle, and environmental contributions to disease onset and progression. In recent years, an emerging focus on neurotoxins has added a new layer of complexity to our understanding of dementia. This editorial aims to discuss recent updates regarding the role of neurotoxins in the pathogenesis of dementia.

Investigation Of Campylobacter Concisus Gastric Epithelial Pathogenicity Using Ags Cells, Christopher Y. M. Luk, Seul A. Lee, Nicholas Naidovski, Fang Liu, Alfred C. Y. Tay, Liang Wang, Stephen Riordan, Li Zhang

Research outputs 2022 to 2026

Campylobacter concisus is an oral bacterium. Recent studies suggest that C. concisus may be involved in human gastric diseases. The mechanisms, however, by which C. concisus causes human gastric diseases have not been investigated. Here we examined the gastric epithelial pathogenicity of C. concisus using a cell culture model. Six C. concisus strains and the human gastric epithelial cell line AGS cells were used. IL-8 produced by AGS cells after incubation with C. concisus was measured using enzyme-linked immunosorbent assay (ELISA), and AGS cell apoptosis was determined by caspase 3/7 activities. The effects of C. concisus on actin arrangement in …

Pain Is Underestimated In Older Adults With Risk Of Falls, Mustafa Atee

Research outputs 2022 to 2026

Dear Editor, I have read with great interest the Xiao et al. study examining ret-rospectively the incidence of falls and related factors in outpatient and inpatient elderly sample (n= 451) aged 65 years and above. . . .

Fluid Biomarkers In Cerebral Amyloid Angiopathy, Seyed M. Savar, Bin Ma, Eugene Hone, Farzana Jahan, Shaun Markovic, Steve Pedrini, Soudabeh Shemehsavar, Vandhana Easwaran, Kevin Taddei, Samantha Gardener, Jasmeer P. Chhatwal, Ellis S. Van Etten, Matthias J. P. Van Osch, Daniel Clarke, Anastazija Gnjec, Mark A. Van Buchem, Marieke J. H. Wermer, Graeme J. Hankey, Steven M. Greenberg, Ralph N. Martins, Hamid R. Sohrabi

Research outputs 2022 to 2026

Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterised by the accumulation of amyloid within the leptomeninges and small/medium-sized cerebral blood vessels. Typically, cerebral haemorrhages are one of the first clinical manifestations of CAA, posing a considerable challenge to the timely diagnosis of CAA as the bleedings only occur during the later disease stages. Fluid biomarkers may change prior to imaging biomarkers, and therefore, they could be the future of CAA diagnosis. Additionally, they can be used as primary outcome markers in prospective clinical trials. Among fluid biomarkers, blood-based biomarkers offer a distinct advantage over cerebrospinal fluid biomarkers …

Reduction And Recovery Of Self-Sustained Muscle Activity After Fatiguing Plantar Flexor Contractions, Anthony J. Blazevich, Ricardo N. O. Mesquita, Ronei S. Pinto, Timothy Pulverenti, Sébastien Ratel

Research outputs 2022 to 2026

Purpose: Persistent inward calcium and sodium currents (PICs) are crucial for initiation and maintenance of motoneuron firing, and thus muscular force. However, there is a lack of data describing the effects of fatiguing exercise on PIC activity in humans. We simultaneously applied tendon vibration and neuromuscular electrical stimulation (VibStim) before and after fatiguing exercise. VibStim induces self-sustained muscle activity that is proposed to result from PIC activation. Methods: Twelve men performed 5-s maximal isometric plantar flexor contractions (MVC) with 5-s rests until joint torque was reduced to 70%MVC. VibStim trials consisted of five 2-s trains of neuromuscular electrical stimulation (20 …

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2023, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

Aboriginal and Torres Strait Islander people have lived on their traditional lands across Australia, including the Torres Strait Islands, for upwards of 50,000 years and their continuity, history and cultural traditions are unrivalled in the world [1,2] . Before colonisation, Aboriginal and Torres Strait Islander people lived in family and community groups, and moved across the land following seasonal changes [1] . Aboriginal and Torres Strait Islander people developed complex societies, trading systems and agricultural activities that were celebrated and recorded in dance, song and stories [2] . The Aboriginal and Torres Strait Islander concept of health is not just …

Developmental Origins Of Psycho-Cardiometabolic Multimorbidity In Adolescence And Their Underlying Pathways Through Methylation Markers: A Two-Cohort Study, Priyanka Choudhary, Justiina Ronkainen, Jennie Carson, Ville Karhunen, Ashleigh Lin, Phillip E. Melton, Marjo-Riitta Jarvelin, Jouko Miettunen, Rae-Chi Huang, Sylvain Sebert

Research outputs 2022 to 2026

Understanding the biological mechanisms behind multimorbidity patterns in adolescence is important as they may act as intermediary risk factor for long-term health. We aimed to explore relationship between prenatal exposures and adolescent’s psycho-cardiometabolic intermediary traits mediated through epigenetic biomarkers, using structural equation modeling (SEM). We used data from mother–child dyads from pregnancy and adolescents at 16–17 years from two prospective cohorts: Northern Finland Birth Cohort 1986 (NFBC1986) and Raine Study from Australia. Factor analysis was applied to generate two different latent factor structures: (a) prenatal exposures and (b) adolescence psycho-cardiometabolic intermediary traits. Furthermore, three types of epigenetic biomarkers were included: …