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Articles 62251 - 62280 of 325133

Full-Text Articles in Medicine and Health Sciences

Preparing For End Of Life In A New Country: A Grounded Theory Study On African Migrants Living In Australia, Gertrude Gondwe Phiri Jan 2024

Preparing For End Of Life In A New Country: A Grounded Theory Study On African Migrants Living In Australia, Gertrude Gondwe Phiri

Theses: Doctorates and Masters

African migration to Australia has grown in the past 20 to 25 years with many migrants staying permanently. This has led to migrants dying away from their birthplaces where family is responsible for end-of-life care planning for the individual. Although migrating to Australia is considered a great achievement, many migrants also experienced challenges. Previous studies have explored the barriers faced by migrants in relation to end-of-life care but have not addressed the cause of those challenges. This constructivist grounded theory study examines how migrants from three African countries, Malawi, Zambia, and Zimbabwe (MZZ) prepare for end-of-life in Australia. The study …


Prevalence Trends Of Foodborne Pathogens, Bacillus Cereus, Non Stec Escherichia Coli And Staphylococcus Aureus In Ready-To-Eat Foods Sourced From Restaurants, Cafés, Catering And Takeaway Food Premises, Nicole Foxcroft Jan 2024

Prevalence Trends Of Foodborne Pathogens, Bacillus Cereus, Non Stec Escherichia Coli And Staphylococcus Aureus In Ready-To-Eat Foods Sourced From Restaurants, Cafés, Catering And Takeaway Food Premises, Nicole Foxcroft

Theses: Doctorates and Masters

The foodborne pathogens of Bacillus cereus (B. cereus), non STEC Escherichia coli (non STEC E. coli) and Staphylococcus aureus (S. aureus) are currently non-notifiable in Australia unless attributed to a food poisoning outbreak. Due to the lack of data around individual cases and isolations in foods, any changes in prevalence may go undetected. The aim of the study was to determine any changes in prevalence of B. cereus, non STEC E. coli and S. aureus in ready-to-eat foods (RTE) sampled from Western Australian restaurants, cafés, catering facilities, and takeaway food premises during the period July 2009 to June 2022. The …


The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson Jan 2024

The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson

Theses: Doctorates and Masters

Background: Delirium is a prevalent acute brain dysfunction in patients within intensive care units. Delirium is marked by a fluctuating mental state, inattention, and altered consciousness. This condition affects a substantial proportion of patients in intensive care units, and which leads to increased mortality, severe physiological and psychological consequences, and a significant economic burden on healthcare systems. Despite the evidence that supports the use of non-pharmacological interventions to prevent or minimise the impact of delirium such as orientation, sensory stimulation, early mobilisation, and family involvement, their implementation in intensive care units remains inconsistent. The involvement of family members in the …


Neuromuscular Adaptations To Different Set Configurations During A Periodized Power Training Block In Elite Junior Judokas, Dale M. Harris, Dustin J. Oranchuk, Christopher Latella Jan 2024

Neuromuscular Adaptations To Different Set Configurations During A Periodized Power Training Block In Elite Junior Judokas, Dale M. Harris, Dustin J. Oranchuk, Christopher Latella

Research outputs 2022 to 2026

Although the impacts of traditional sets (TS) versus cluster (CL) sets resistance training have been broadly explored among recreationally trained populations, no studies have previously compared these set configurations among elite Judokas. Twenty-two elite male and female Judokas (age = 17.5 ± 1.2 years) performed identical periodized 4-week hypertrophy and strength blocks (8 weeks in total). Following this, for the final 4-week power training block, the cohort was separated into either TS (n = 11) or CL (n = 11) set structures. CL were prescribed by including 45-second intra-set rest every two repetitions. One-repetition maximum (1RM) and peak barbell velocities …


Suboptimal Health Status, Covid-19 Psychology, And Cultural Value Impact On Post-Pandemic Outbound Travel, Danni Zheng, Yangyang Jiang, Jun Wen, Ian Phau, Haifeng Hou, Wei Wang Jan 2024

Suboptimal Health Status, Covid-19 Psychology, And Cultural Value Impact On Post-Pandemic Outbound Travel, Danni Zheng, Yangyang Jiang, Jun Wen, Ian Phau, Haifeng Hou, Wei Wang

Research outputs 2022 to 2026

Suboptimal health has become a core public health challenge, especially during the pandemic. This study adopts an interdisciplinary perspective to examine the relationships between suboptimal health status, COVID-19 fear and stress, cultural values, and outbound travel. A theoretical model was evaluated using data from 800 Beijing residents, 439 of whom were in suboptimal health. Four dimensions of suboptimal health (fatigue, mental status, immune system, and cardiovascular system) significantly affected COVID-19 stress and fear. Post-pandemic travel intention was positively related to fatigue symptoms and leisure and life enjoyment but negatively associated with COVID-19 stress. Suggestions for highlighting travellers’ health status and …


Changes In Deadlift Six Repetition Maximum, Countermovement Jump Performance, Barbell Velocity, And Perceived Exertion Over The Duration Of A Microcycle, Stuart N. Guppy, Tsuyoshi Nagatani, Wayne C. K. Poon, Kristina L. Kendall, Jason P. Lake, G. Gregory Haff Jan 2024

Changes In Deadlift Six Repetition Maximum, Countermovement Jump Performance, Barbell Velocity, And Perceived Exertion Over The Duration Of A Microcycle, Stuart N. Guppy, Tsuyoshi Nagatani, Wayne C. K. Poon, Kristina L. Kendall, Jason P. Lake, G. Gregory Haff

Research outputs 2022 to 2026

The primary aim of this study was to investigate the stability of the six-repetition maximum (6RM) deadlift over the length of a five-day microcycle and whether the fatigue induced by maximal effort testing detrimentally impacted preparedness. Twelve participants performed four testing sessions, comprising a one-repetition maximum test and three 6RM tests separated by 48 hours. Countermovement jumps were performed before each testing session, and barbell velocity was measured during each warm-up set to assess changes in preparedness. The 6RM deadlift was not statistically different between any of the testing sessions (p  =  .056; ηp2  =  0.251). Similarly, …


Changes In Sleep Effort Mediate Insomnia Severity In Older Adults Following Online Cognitive Behavioural Therapy, Yvonne Kutzer, Lisa Whitehead, Eimear Quigley, Mandy Stanley Jan 2024

Changes In Sleep Effort Mediate Insomnia Severity In Older Adults Following Online Cognitive Behavioural Therapy, Yvonne Kutzer, Lisa Whitehead, Eimear Quigley, Mandy Stanley

Research outputs 2022 to 2026

Background

To examine treatment mechanisms of digitally delivered cognitive behavioural therapy for insomnia (CBT-I), this study assessed the mediating effects of dysfunctional beliefs, hyperarousal, locus of control, self-efficacy, sleep effort, and safety behaviours on self-reported insomnia severity in older adults before and following the completion of a self-guided, online CBT-I program.

Methods

The baseline and follow-up measurements were completed by 62 older adults (55 female, 89%). This was a two-condition within-participant design. Mediation analysis using a parallel mediation model was conducted using the MEMORE macro for repeated measure designs.

Results

Out of all the included mediator variables, only a reduction …


Blood Eosinophil-Guided Oral Prednisolone For Copd Exacerbations In Primary Care In The Uk (Starr2): A Non-Inferiority, Multicentre, Double-Blind, Placebo-Controlled, Randomised Controlled Trial, Sanjay Ramakrishnan, Helen Jeffers, Beverly Langford-Wiley, Joanne Davies, Samantha J. Thulborn, Mahdi Mahdi, Christine A'Court, Ian Binnian, Stephen Bright, Simon Cartwright, Victoria Glover, Alison Law, Robin Fox, Adam Jones, Christopher Davies, David Copping, Richard E. K. Russell, Mona Bafadhel Jan 2024

Blood Eosinophil-Guided Oral Prednisolone For Copd Exacerbations In Primary Care In The Uk (Starr2): A Non-Inferiority, Multicentre, Double-Blind, Placebo-Controlled, Randomised Controlled Trial, Sanjay Ramakrishnan, Helen Jeffers, Beverly Langford-Wiley, Joanne Davies, Samantha J. Thulborn, Mahdi Mahdi, Christine A'Court, Ian Binnian, Stephen Bright, Simon Cartwright, Victoria Glover, Alison Law, Robin Fox, Adam Jones, Christopher Davies, David Copping, Richard E. K. Russell, Mona Bafadhel

Research outputs 2022 to 2026

Background: Systemic glucocorticoids are recommended for use in chronic obstructive pulmonary disease (COPD) exacerbations; however, there is increased harm associated with their use. We hypothesised that the use of eosinophil biomarker-directed oral prednisolone therapy at the time of an exacerbation of COPD was effective at reducing prednisolone use without affecting adverse outcomes. Methods: The studying acute exacerbations and response (STARR2) study was a multicentre, randomised, double-blind, placebo-controlled trial conducted in 14 primary care practices in the UK. We included adults (aged ≥ 40 years), who were current or former smokers (with at least a 10 pack year smoking history) with …


Health Behaviour Profiles In Young Australian Adults In Relation To Physical And Mental Health: The Raine Study, Cecilie Thøgersen-Ntoumani, Daniel F. Gucciardi, Joanne A. Mcveigh, Therese A. O'Sullivan, Manon Dontje, Emmanuel Stamatakis, Peter R. Eastwood, Leon Straker Jan 2024

Health Behaviour Profiles In Young Australian Adults In Relation To Physical And Mental Health: The Raine Study, Cecilie Thøgersen-Ntoumani, Daniel F. Gucciardi, Joanne A. Mcveigh, Therese A. O'Sullivan, Manon Dontje, Emmanuel Stamatakis, Peter R. Eastwood, Leon Straker

Research outputs 2022 to 2026

Issues Addressed: We aimed to identify latent health behaviour profiles of young adults and examine their associations with physical and mental health outcomes. We also characterised the profiles by socio-demographic characteristics. Methods: Data were collected between 2012 and 2014. Participants (N = 476) were young adults (M age [SD] = 22.1 [.57] years) from Generation 2 of the Raine Study longitudinal cohort. Health behaviours were measured via ActiGraph GT3X waist monitors (physical activity, sedentary behaviour) and questionnaires (diet quality, alcohol, smoking and sleep). Physical and mental health were measured using clinical health assessments, blood biomarkers, and questionnaires. Latent Profile Analysis …


Hidden And Unacknowledged: The Mental Health And Psychosocial Interventions Delivered By School Nurses In Western Australia, Anita Moyes, Shirley Mcgough, Dianne Wynaden Jan 2024

Hidden And Unacknowledged: The Mental Health And Psychosocial Interventions Delivered By School Nurses In Western Australia, Anita Moyes, Shirley Mcgough, Dianne Wynaden

Research outputs 2022 to 2026

Schools are an important setting for the early identification, assessment and intervention of mental health problems in children and young people. Internationally, many nurses work in schools, but the role of this group with young people experiencing mental health problems has had only limited investigation. This study explored the activities school nurses undertook with young people experiencing mental health problems in Australia. Reporting was guided by the COREQ checklist. Thirty-one nurses participated in a semi-structured interview. Data were analysed using the constant comparative method of analysis as developed by Glaser and Strauss (1967). The findings identified that nurses working in …


In Vivo Human Medial Gastrocnemius Fascicle Behaviour And Belly Gear During Submaximal Eccentric Contractions Are Not Affected By Concentric Fatiguing Exercise, Matheus Daros Pinto, Kazunori Nosaka, Anthony J. Blazevich Jan 2024

In Vivo Human Medial Gastrocnemius Fascicle Behaviour And Belly Gear During Submaximal Eccentric Contractions Are Not Affected By Concentric Fatiguing Exercise, Matheus Daros Pinto, Kazunori Nosaka, Anthony J. Blazevich

Research outputs 2022 to 2026

Changes in muscle geometry and belly gearing during eccentric contractions influence fibre strain and susceptibility to muscle damage. They are modulated by the interaction between connective tissues and intracellular-intrafascicular fluid pressures and external pressures from neighbouring structures. Fatiguing exercise triggers fluid shifts (muscle swelling) and muscle activation changes that may influence these modulators. Our purpose was to measure medial gastrocnemius (MG) geometric changes in vivo during eccentric contractions before and after maximal concentric muscle work to test the hypothesis that fatigue would reduce fascicle rotation and muscle gear and provoke greater fascicle strain. Submaximal eccentric plantar flexor contractions at 40% …


Predicting Neurodegeneration From Sleep Related Biofluid Changes, Yue Yang, Woojin S. Kim, Johannes C. Michaelian, Simon J. G. Lewis, Craig L. Phillips, Angela L. D'Rozario, Pratishtha Chatterjee, Ralph N. Martins, Ron Grunstein, Glenda M. Halliday, Sharon L. Naismith Jan 2024

Predicting Neurodegeneration From Sleep Related Biofluid Changes, Yue Yang, Woojin S. Kim, Johannes C. Michaelian, Simon J. G. Lewis, Craig L. Phillips, Angela L. D'Rozario, Pratishtha Chatterjee, Ralph N. Martins, Ron Grunstein, Glenda M. Halliday, Sharon L. Naismith

Research outputs 2022 to 2026

Sleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potentially either representing an early stage of the disease itself or acting as a pathophysiological driver. Therefore, discovering biomarkers that identify individuals with sleep-wake disturbances who are at risk of developing neurodegenerative diseases will allow early diagnosis and intervention. Given the association between sleep and neurodegeneration, the most frequently analyzed fluid biomarkers in people with sleep-wake disturbances to date include those directly associated with neurodegeneration itself, such as neurofilament light chain, phosphorylated tau, amyloid-beta and alpha-synuclein. Abnormalities in these biomarkers in patients with sleep-wake disturbances …


Quantitative Comparison Of Presenilin Protein Expression Reveals Greater Activity Of Ps2-Γ-Secretase, Melissa K. Eccles, Nathan Main, Rodrigo Carlessi, Ayeisha M. Armstrong, Miheer Sabale, Brigid Roberts-Mok, Janina E. E. Tirnitz-Parker, Mark Agostino, David Groth, Paul E. Fraser, Giuseppe Verdile Jan 2024

Quantitative Comparison Of Presenilin Protein Expression Reveals Greater Activity Of Ps2-Γ-Secretase, Melissa K. Eccles, Nathan Main, Rodrigo Carlessi, Ayeisha M. Armstrong, Miheer Sabale, Brigid Roberts-Mok, Janina E. E. Tirnitz-Parker, Mark Agostino, David Groth, Paul E. Fraser, Giuseppe Verdile

Research outputs 2022 to 2026

γ-secretase processing of amyloid precursor protein (APP) has long been of interest in the pathological progression of Alzheimer's disease (AD) due to its role in the generation of amyloid- . The catalytic component of the enzyme is the presenilins of which there are two homologues, Presenilin-1 (PS1) and Presenilin-2 (PS2). The field has focussed on the PS1 form of this enzyme, as it is typically considered the more active at APP processing. However, much of this work has been completed without appropriate consideration of the specific levels of protein expression of PS1 and PS2. We propose that expression is an …


Study Protocol For A Stepped-Wedge Cluster (Nested) Randomized Controlled Trial Of Antenatal Colostrum Expression (Ace) Instruction In First-Time Mothers: The Ace Study, Cassandra Cuffe, Roslyn Giglia, Matthew N. Cooper, Julie Hill, Desiree Silva, Anita M. Moorhead, Valerie Verhasselt, Joshua R. Lewis, Deborah Ireson, Jill R. Demirci, Talea Cotte, Kathryn Webb, Frances Patey, Therese A. O’Sullivan Jan 2024

Study Protocol For A Stepped-Wedge Cluster (Nested) Randomized Controlled Trial Of Antenatal Colostrum Expression (Ace) Instruction In First-Time Mothers: The Ace Study, Cassandra Cuffe, Roslyn Giglia, Matthew N. Cooper, Julie Hill, Desiree Silva, Anita M. Moorhead, Valerie Verhasselt, Joshua R. Lewis, Deborah Ireson, Jill R. Demirci, Talea Cotte, Kathryn Webb, Frances Patey, Therese A. O’Sullivan

Research outputs 2022 to 2026

Background: Although many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers. Methods and Planned Analysis: This multicenter stepped-wedge cluster (nested) randomized controlled trial aims to recruit 945 nulliparous pregnant individuals. The trial is conducted in two phases. During Phase 1, control group participants are under standard care. …


Topical Antibiotics Prophylaxis For Infections Of Indwelling Pleural/Peritoneal Catheters (Tap-Ipc): A Pilot Study, Estee P. M. Lau, Sam Faber, Chloe Charlesworth, Sue Morey, Sona Vekaria, Pierre Filion, Aron Chakera, Y. C.Gary Lee Jan 2024

Topical Antibiotics Prophylaxis For Infections Of Indwelling Pleural/Peritoneal Catheters (Tap-Ipc): A Pilot Study, Estee P. M. Lau, Sam Faber, Chloe Charlesworth, Sue Morey, Sona Vekaria, Pierre Filion, Aron Chakera, Y. C.Gary Lee

Research outputs 2022 to 2026

Background and Objective: Indwelling pleural catheter (IPC) and indwelling peritoneal catheter (IPeC) have established roles in the management of malignant pleural and peritoneal effusions but catheter-related infections remain a major concern. Topical mupirocin prophylaxis has been shown to reduce peritoneal dialysis catheter infections. This study aimed to assess the (i) compatibility of IPC with mupirocin and (ii) feasibility, tolerability and compliance of topical mupirocin prophylaxis in patients with an IPC or IPeC. Methods: (i) Three preparations of mupirocin were applied onto segments of IPC thrice weekly and examined with scanning electron microscope (SEM) at different time intervals. (ii) Consecutive patients …


Association Of Abnormal Lung Function And Its Subtypes With Arterial Stiffness: A Longitudinal Cohort Study, Zhiyuan Wu, Haiping Zhang, Yue Jiang, Zhiwei Li, Yutao Wang, Yixing Tian, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Xiuhua Guo Jan 2024

Association Of Abnormal Lung Function And Its Subtypes With Arterial Stiffness: A Longitudinal Cohort Study, Zhiyuan Wu, Haiping Zhang, Yue Jiang, Zhiwei Li, Yutao Wang, Yixing Tian, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Xiuhua Guo

Research outputs 2022 to 2026

BACKGROUND: Prior studies have reported the cross-sectional relationship between lung function and arterial stiffness, while the longitudinal association remains unclear to date. This study aimed to investigate whether abnormal lung function and its subtypes at baseline are associated with increased arterial stiffness using a cohort. METHODS AND RESULTS: This was a secondary analysis extracting 2461 participants from Beijing Health Management Cohort as baseline and annually followed for development of arterial stiffness. Abnormal lung function was defined by forced expiratory volume in 1s < 80% of the predicted value, forced vital capacity of the predicted value, or forced expiratory volume in 1s/ forced vital capacity ratio < 70%. Increased arterial stiffness was determined by brachial-ankle pulse wave velocity ≥ 1400 cm/s. Cox proportional hazards model was used to calculate the hazard ratio and population attributable fraction. The mean age was 42.8±8.1 years, and 444 (18.0%) cases developed increased arterial stiffness during a median follow-up of 3.0 years. The adjusted hazard ratio (95% CI) of arterial stiffness was 1.47 (95% CI, 1.10–1.96) for abnormal lung function, with a population attributable fraction of 3.9% (95% CI, 0.8–7.1). Of subtypes, only obstructive ventilatory dysfunction was significantly associated with arterial stiffness (adjusted hazard ratio, 2.06 [95% CI, 1.27–3.36]), not restricted ventilatory dysfunction (adjusted hazard ratio, 0.95 [95% CI, 0.54–1.65]). Consistent results were observed on multiple sensitivity analyses. CONCLUSIONS: Our study indicated a longitudinal association of abnormal lung function with increased arterial stiffness using a large cohort, especially for the obstructive ventilatory dysfunction.


Criteria And Indicators For Centers Of Clinical Excellence In Stroke Recovery And Rehabilitation: A Global Consensus Facilitated By Isrra, Rachel C. Stockley, Marion F. Walker, Margit A. Murphy, Noor A. A. Aziz, Philemon Amooba, Leonid Churliov, Amanda Farrin, Natalie A. Fini, Emma Ghaziani, Erin Godecke, Tania Gutierrez-Panchana, Jie Jia, Thoshenthri Kandasamy, Patrice Lindsay, John Solomon, Vincent Thijs, Tierney Tindall, Donna C. Tippett, Caroline Watkins, Elizabeth Lynch Jan 2024

Criteria And Indicators For Centers Of Clinical Excellence In Stroke Recovery And Rehabilitation: A Global Consensus Facilitated By Isrra, Rachel C. Stockley, Marion F. Walker, Margit A. Murphy, Noor A. A. Aziz, Philemon Amooba, Leonid Churliov, Amanda Farrin, Natalie A. Fini, Emma Ghaziani, Erin Godecke, Tania Gutierrez-Panchana, Jie Jia, Thoshenthri Kandasamy, Patrice Lindsay, John Solomon, Vincent Thijs, Tierney Tindall, Donna C. Tippett, Caroline Watkins, Elizabeth Lynch

Research outputs 2022 to 2026

Background: The aim of the International Stroke Recovery and Rehabilitation Alliance is to create a world where worldwide collaboration brings major breakthroughs for the millions of people living with stroke. A key pillar of this work is to define globally relevant criteria for centers that aspire to deliver excellent clinical rehabilitation and generate exceptional outcomes for patients. Objectives: This paper presents consensus work conducted with an international group of expert stroke recovery and rehabilitation researchers, clinicians, and people living with stroke to identify and define criteria and measurable indicators for Centers of Clinical Excellence (CoCE) in stroke recovery and rehabilitation. …


Dose-Response Effects Of Exercise On Mental Health In Community-Dwelling Older Adults: Exploration Of Genetic Moderators, Swathi Gujral, Marcia Burns, Kirk I. Erickson, Dana Rofey, Jeremiah J. Peiffer, Simon M. Laws, Belinda Brown Jan 2024

Dose-Response Effects Of Exercise On Mental Health In Community-Dwelling Older Adults: Exploration Of Genetic Moderators, Swathi Gujral, Marcia Burns, Kirk I. Erickson, Dana Rofey, Jeremiah J. Peiffer, Simon M. Laws, Belinda Brown

Research outputs 2022 to 2026

Background/Objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms.

Method: This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE 4 carrier status were …


Immune Checkpoint Inhibitor Therapy For Advanced Cutaneous Squamous Cell Carcinoma In Australia: A Retrospective Real World Cohort Study, Luke S. Mclean, Annette M. Lim, Mathias Bressel, Jenny Lee, Rahul Ladwa, Alexander D. Guminski, Brett Hughes, Samantha Bowyer, Karen Briscoe, Samuel Harris, Craig Kukard, Rob Zielinski, Muhammad Alamgeer, Matteo Carlino, Jeremy Mo, John J. Park, Muhammad A. Khattak, Fiona Day, Danny Rischin Jan 2024

Immune Checkpoint Inhibitor Therapy For Advanced Cutaneous Squamous Cell Carcinoma In Australia: A Retrospective Real World Cohort Study, Luke S. Mclean, Annette M. Lim, Mathias Bressel, Jenny Lee, Rahul Ladwa, Alexander D. Guminski, Brett Hughes, Samantha Bowyer, Karen Briscoe, Samuel Harris, Craig Kukard, Rob Zielinski, Muhammad Alamgeer, Matteo Carlino, Jeremy Mo, John J. Park, Muhammad A. Khattak, Fiona Day, Danny Rischin

Research outputs 2022 to 2026

Objectives: To review the outcomes of immune checkpoint inhibitor (ICI) treatment of advanced cutaneous squamous cell carcinoma (CSCC) outside clinical trials. Study design: Retrospective observational study; review of patient records in fifteen Australian institutions. Setting, participants: All Australian adults with locally advanced or metastatic CSCC not amenable to curative surgery or radiotherapy treated with ICIs, 5 May 2017 – 23 May 2022, through a cemiplimab compassionate access scheme (Therapeutic Goods Administration Special Access Scheme) or who personally covered the cost of pembrolizumab prior to the start of the access scheme. Main outcome measures: Best overall response rate (ORR) according to …


Metagenomic Characterisation Of The Gut Microbiome And Effect Of Complementary Feeding On Bifidobacterium Spp. In Australian Infants, Kimberley Parkin, Debra J. Palmer, Valerie Verhasselt, Nelly Amenyogbe, Matthew N. Cooper, Claus T. Christophersen, Susan L. Prescott, Desiree Silva, David Martino Jan 2024

Metagenomic Characterisation Of The Gut Microbiome And Effect Of Complementary Feeding On Bifidobacterium Spp. In Australian Infants, Kimberley Parkin, Debra J. Palmer, Valerie Verhasselt, Nelly Amenyogbe, Matthew N. Cooper, Claus T. Christophersen, Susan L. Prescott, Desiree Silva, David Martino

Research outputs 2022 to 2026

Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine whether the age at which solid foods are introduced differentially affects the microbiota in predominantly breastfed infants compared with predominantly formula-fed infants. We performed whole-genome shotgun metagenomic sequencing of infant stool samples from a cohort of six-month-old Australian infants enrolled in a nested study within the ORIGINS Project longitudinal birth cohort. Infants born preterm or those who had been administered antibiotics since birth were excluded. …


Neuropsychiatric Symptoms Of Dementia In Those With And Without A Recorded History Of Psychological Trauma: A Comparative Study From An Australian Dementia Support Service, Monica Cations, Mustafa Atee, Thomas Morris, Daniel Whiting Jan 2024

Neuropsychiatric Symptoms Of Dementia In Those With And Without A Recorded History Of Psychological Trauma: A Comparative Study From An Australian Dementia Support Service, Monica Cations, Mustafa Atee, Thomas Morris, Daniel Whiting

Research outputs 2022 to 2026

Objective: To compare the number and severity of neuropsychiatric symptoms (NPS) and associated caregiver distress between those with and without a noted history of psychological trauma among those referred to a specialised national dementia NPS support service. Methods: This was a 5-year retrospective observational study of records from the Dementia Support Australia NPS support service. NPS were reported by formal or informal caregivers at service entry using the Neuropsychiatric Inventory Nursing Home version or Questionnaire version. A history of psychological trauma was recorded in the person's social or medical history and/or endorsed as a contributor to NPS by a trained …


Quantifying Uptake And Completion Of Pulmonary Rehabilitation Programs In People With Chronic Obstructive Pulmonary Disease Known To Tertiary Care, Sarah Hug, Vinicius Cavalheri, Daniel F. Gucciardi, Kylie Hill Jan 2024

Quantifying Uptake And Completion Of Pulmonary Rehabilitation Programs In People With Chronic Obstructive Pulmonary Disease Known To Tertiary Care, Sarah Hug, Vinicius Cavalheri, Daniel F. Gucciardi, Kylie Hill

Research outputs 2022 to 2026

Background: People with symptomatic chronic obstructive pulmonary disease (COPD) benefit from pulmonary rehabilitation programs (PRPs), but program attrition is common. Methods: For people with COPD who presented to tertiary care and appeared appropriate for a PRP, we prospectively mapped their PRP journey, explored factors influencing attendance to pre-program assessment and captured program attrition. Results: Of the 391 participants, 31% (95% CI 27 to 36) were referred to a PRP (n = 123; age 68 ± 10years, 62 males [50%], FEV1 45 ± 19%predicted). Of those referred, 94 (76% [69 to 84]) attended a pre-program assessment. Ex-smokers and those who had …


Staff Perceptions On The Effectiveness Of Grip-S, A New Approach To Clinical Supervision Incorporating Safewards: An Interpretive Phenomenological Analysis, Jennifer Hamilton, Amanda Cole, Richard Bostwick, Irene Ngune Jan 2024

Staff Perceptions On The Effectiveness Of Grip-S, A New Approach To Clinical Supervision Incorporating Safewards: An Interpretive Phenomenological Analysis, Jennifer Hamilton, Amanda Cole, Richard Bostwick, Irene Ngune

Research outputs 2022 to 2026

This study explored the impact of an innovative approach to clinical supervision for mental health nurses which integrates Safewards, named Group Reflective integrated Practice with Safewards–GRiP-S. Qualitative data was collected through 10 individual semi-structured interviews with nursing staff who had participated within the clinical supervision approach. Interviews provided insights into the nursing staff’s perception and experience of the clinical supervision approach. Through interpretive phenomenological analysis six themes emerged (i) illuminating embodied practice of Safewards, (ii) building confidence through empowering connections, (iii) creating a culture of positive change, (iv) identifying internal motivation for and external barriers to supervision engagement, (v) navigating …


The Benefits, Barriers And Facilitators Of Mentoring Programs For First-Year Doctors: A Systematic Review, Joelle Winderbaum, Linda L. L. Coventry Jan 2024

The Benefits, Barriers And Facilitators Of Mentoring Programs For First-Year Doctors: A Systematic Review, Joelle Winderbaum, Linda L. L. Coventry

Research outputs 2022 to 2026

Introduction: The transition from medical student to first-year doctor is notoriously difficult, yielding a high rate of transition failure, burn-out and mental health deterioration. Doctors in this cohort experience unique challenges during this time, which manifest through performance gaps, issues of professional identity, new occupational pressures, and cultural expectations. Mentoring programs are commonly utilised in the medical profession to foster personal and professional development and improve psychosocial well-being and career satisfaction. However, there exist no systematic reviews examining the use of mentorship specifically for the first-year doctor cohort, given the unique transition challenges faced by this vulnerable group. Purpose: Due …


Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead Jan 2024

Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead

Research outputs 2022 to 2026

Background: Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. Methods: PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched. Two independent reviewers screened, extracted, and quality-appraised the studies using JBI SUMARI software. Forest plots were created with the standardized mean difference using the random-effects model, and heterogeneity was assessed using I2. …


The Report Of Access And Engagement With Digital Health Interventions Among Children And Young People: Systematic Review, Lisa Whitehead, Suzanne Robinson, Diana Arabiat, Mark Jenkins, Evalotte Morelius Jan 2024

The Report Of Access And Engagement With Digital Health Interventions Among Children And Young People: Systematic Review, Lisa Whitehead, Suzanne Robinson, Diana Arabiat, Mark Jenkins, Evalotte Morelius

Research outputs 2022 to 2026

Background: Digital health interventions are increasingly used to deliver health-related interventions for children and young people to change health behaviors and improve health outcomes. Digital health interventions have the potential to enhance access to and engagement with children and young people; however, they may also increase the divide between those who can access technology and are supported to engage and those who are not. This review included studies that reported on the access to or engagement with digital health interventions among children and young people. Objective: This review aims to identify and report on access and engagement in studies involving …


A Systematic Review Of Dementia Research Priorities, Manonita Ghosh, Pelden Chejor, Melanie Baker, Davina Porock Jan 2024

A Systematic Review Of Dementia Research Priorities, Manonita Ghosh, Pelden Chejor, Melanie Baker, Davina Porock

Research outputs 2022 to 2026

Introduction: Patient involvement is a critical component of dementia research priority-setting exercises to ensure that research benefits are relevant and acceptable to those who need the most. This systematic review synthesises research priorities and preferences identified by people living with dementia and their caregivers. Methods: Guided by Joanna Briggs Institute methodology, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework, we conducted a systematic search in five electronic databases: CINAHL, Medline, PsycINFO, Web of Science and Scopus. The reference lists of the included studies were also manually searched. We combined quantitative and qualitative data for synthesis and descriptive thematic …


Exercise Professional Education, Qualifications, And Certifications: A Content Analysis Of Job Postings In The United States, Rachele Pojednic, Devin P. O’Neill, Molly G. Flanagan, Alexis Bartlett, Byron L. G. Carter, Mary A. Kennedy Jan 2024

Exercise Professional Education, Qualifications, And Certifications: A Content Analysis Of Job Postings In The United States, Rachele Pojednic, Devin P. O’Neill, Molly G. Flanagan, Alexis Bartlett, Byron L. G. Carter, Mary A. Kennedy

Research outputs 2022 to 2026

Introduction: Growth in the field of clinical exercise science and the potential impacts on overall health and wellbeing have driven the need for qualified, clinically trained, exercise professionals. And yet, it is not well understood what specific credentials employers are seeking when hiring exercise professionals. Purpose: The purpose of the study was to examine the qualification requirements for professionals seeking employment in exercise science, exercise physiology, kinesiology or equivalent fields. Methods: Search platforms Indeed.com and USAJobs.gov were examined within a two week period in 2022. Search terms included “Exercise Physiology”, “Exercise Science”, “Exercise Professional”, “Exercise Prescription”, “Exercise Specialist”, and “Kinesiology”. …


Overview Of Aboriginal And Torres Strait Islander Health Status 2023, Australian Indigenous Healthinfonet Jan 2024

Overview Of Aboriginal And Torres Strait Islander Health Status 2023, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

The main purpose of the Overview of Aboriginal and Torres Strait Islander health status (Overview) is to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander people. The Overview has been prepared by HealthInfoNet staff as part of our contribution to supporting those who work in the Aboriginal and Torres Strait Islander health sector. The Overview is a key indicator of the HealthInfoNet’s commitment to authentic and engaged knowledge development and exchange.

The initial sections of this Overview provide information about the context of Aboriginal and …


Associations Of Vegetable And Potato Intakes With Markers Of Type 2 Diabetes Risk In The Ausdiab Cohort: Supplemental Information, Pratik Pokharel, Lauren C. Blekkenhorst, Catherine P. Bondonno, Kevin Murray, Simone Radavelli-Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno Jan 2024

Associations Of Vegetable And Potato Intakes With Markers Of Type 2 Diabetes Risk In The Ausdiab Cohort: Supplemental Information, Pratik Pokharel, Lauren C. Blekkenhorst, Catherine P. Bondonno, Kevin Murray, Simone Radavelli-Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2022 to 2026

No abstract provided.