Medicine and Health Sciences Commons^™

Dual Gallium Drug Treatment Against Carbapenem-Resistant Klebsiella Pneumoniae: Efficacy And Potential Mechanism(S) Of Action And Resistance, Zachary Scott, Seoung-Ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy

Journal Articles: Pathology and Microbiology

Klebsiella pneumoniae (KLP) is a Gram-negative pathogen that can be highly antibiotic-resistant. Our group has worked with gallium-based compounds as a means of treating bacterial infections. Here the possible mechanism is investigated for dual therapy comprised of gallium nitrate (Ga(NO₃)₃) and gallium protoporphyrin (GaPP) on KLP. It is found that in vitro the combination of Ga(NO₃)₃ and GaPP is synergistic against KLP. The in vivo efficacy is of the dual therapy is additionally tested by treating pulmonary KLP infections in mice. Much greater effectiveness are observed in bacterial clearance and survival of mice …

Tetracycline And Oxacillin Act Synergistically On Biofilms And Display Increased Efficacy In Vivo Against Staphylococcus Aureus, Amy K. Tooke, Rebecca E. Hodges, Josie F. Pyrah, Kenneth W. Bayles, Stephen A. Renshaw, Simon J. Foster

Journal Articles: Pathology and Microbiology

Oxacillin (bactericidal) and tetracycline (bacteriostatic) are clinically relevant antibiotics that are routinely prescribed to treat Staphylococcus aureus infections but not conventionally used in combination. There is an urgent need for treatment regimens that can act upon biofilms during infection, associated with chronic infections on indwelling devices, as well as acute planktonic (systemic) infection. Here we show that in an in vitro model oxacillin and tetracycline act synergistically against S. aureus UAMS-1 biofilms, reducing the concentration of both antibiotics necessary to eradicate an established biofilm. Using an in vivo zebrafish larval infection model with S. aureus NewHG, they display improved bacterial …

The Effect Of Using Letrozole Alone Protocol Versus Using Letrozole And Hcg Protocol On Induction Of Ovulation In Polycystic Ovarian Syndrome Patients: A Prospective Cohort Study, Ahmed A. Kassab, Ahmed M. Salman, Heba M. Khattab, Ali Khayal, Sherif Abdelmordy, Mohammed I. Elazab

Journal of Medicine in Scientific Research

Background: This study seeks to question the customary utilization of HCG in straightforward letrozole induction methods, proposing its restricted requirement in particular instances, perhaps diminishing expenses and anxiety for infertile couples.

Material and Methods: This is a prospective cohort study was done at the assisted reproductive unit in Ahmed Maher teaching hospital in Cairo. The study includes 132 infertile women aged 18 to 35 with PCOS, free from other medical disorders and not taking conflicting medications.

Prerequisites involve normal hysterosalpingography and semen analysis. Participants were evenly divided into two groups: the first receiving letrozole exclusively for ovulation induction, and the …

How Does Plasma L-Fabp Level Correlate With Cardiovascular Disease Risk In Patients With Chronic Kidney Disease, And Can It Serve As A Reliable Biomarker For Risk Stratification?”, Nehad Refat Ibrahim, Ghadir Elsawy

Journal of Medicine in Scientific Research

Chronic kidney disease (CKD) affects up to 10% of the global adult population, with cardiovascular disease (CVD) being a major concern. CKD patients face increased CVD-related morbidity and mortality. While the exact mechanisms linking CKD and CVD are complex, traditional risk factors (e.g., diabetes, hypertension) and nontraditional factors (e.g., inflammation, oxidative stress) play a role. Liver-type fatty acid-binding protein (L-FABP) is associated with lipid metabolism and kidney injury. Few studies suggest L-FABP as a potential biomarker for CVD risk in CKD patients, but further research is needed to fully understand its role. This study aims to explore the link between …

Infectious Causes Of Cavernous Thrombosis: A Rare Case Of Mastoiditis, Koshin Ahmed, Suresh Antony

Central & West Texas GME Research Day 2024

No abstract provided.

Pantoprazole Induced Pancytopenia In A Post-Chemotherapy Patient: A Case Report, Rohan Divecha, Caleb Nieves, Paul Mathew

Central & West Texas GME Research Day 2024

No abstract provided.

Mycobacterium Flavescens Infection: An Unusual Case Of Prosthetic Joint Infection, Peter Holleb, Suresh Antony

Central & West Texas GME Research Day 2024

No abstract provided.

Cortisol In Elderly Trauma Patients, Sophia Jimenez, Ernest Gonzalez, Leslee Keilty, Carol Wang

Central & West Texas GME Research Day 2024

No abstract provided.

Second Trimester Uterine Rupture With Abnormal Vascularity Of The Lower Uterine Segment, Munsa Manandhar, Linda Haddox

Central & West Texas GME Research Day 2024

No abstract provided.

A Case Of Underlying Inflammation Mistaken For Ascites, Zuhaib Murtaza, Mattia Walter, Joseph Sammarco, Micheline Tantchou, Oscar Garcia

Central & West Texas GME Research Day 2024

No abstract provided.

An Unexpected Outcome Of An Ischemic Stroke On Reward Pathways In The Human Brain, Karen Valdez-Cuen, Erica Kozorosky, Ferina Farahnik, Oscar Garcia

Central & West Texas GME Research Day 2024

No abstract provided.

Conservative Management Trial For Acute Perforated Diverticulitis, Armand Edalati, Astha Bhatt, Bita Crystal Behaeddin, Tanya Ramadoss, Sophia Hai, Elizabeth Geyer-Roberts

East Florida Division GME Research Day 2024

No abstract provided.

Surgical Emergency In Atypical Chest Pain: Debridement For Necrotizing Fasciitis Of The Left Shoulder, Bita Behaeddin, Elizabeth Geyers-Roberts, Armand Edalati, Jula Grote, Daniel Matienzo, Rachel Rauber, Rafael Sierra

East Florida Division GME Research Day 2024

No abstract provided.

Quality Improvement: A1c Control And Phq-9 Scores In Adults With Diabetes Type 2, Kenoviah Heron, Julia Fashner

East Florida Division GME Research Day 2024

No abstract provided.

Disseminated Peritoneal Leiomyomatosis Mimicking Carcinomatosis, Matthew Lee, Gabriella Morey, Susana Ferra

East Florida Division GME Research Day 2024

No abstract provided.

An Unique Presentation Of Giant Hydronephrosis, Mathew Blesson, Alex Lima, Sheena Pubien, Patricia Milanes, Jorge Garcia, Enny Cancio

East Florida Division GME Research Day 2024

No abstract provided.

An Interesting Case Of Modern Day Scurvy, Petar Jen, Jessica Cook, Elise Clark, Laurence Dubensky

East Florida Division GME Research Day 2024

No abstract provided.

Osteopathic Manipulative Techniques (Omt) In Concussion Management: A Literature Review, Sushil Talreja, Annette Santiago

East Florida Division GME Research Day 2024

No abstract provided.

Bilateral Renal Artery Thrombosis Presenting As Intractable Abdominal Pain, Yanie Oliva, Ricardo Llorente, Connor Brittain, Ilde Manuel Lee, Boris Ryabtsev, Orlando Enrizo

East Florida Division GME Research Day 2024

No abstract provided.

Depressive Pseudodementia As The Cause Of Cognitive Impairment In A 48-Year-Old Female, Jose Mendoza-Sierra

East Florida Division GME Research Day 2024

No abstract provided.

Metastatic Adrenocortical Carcinoma, Beau Blazek, Andrew Chen, Sanaz Siran, Angelina Rodriguez

Far West Division GME Research Day 2024

No abstract provided.

Do The Anti-Inflammatory Effects Of Statins Benefit Patients In Inflammatory Bowel Disease Flares?, Boyd Caro, Vamsee Mupparaju, Vanessa Florival, Ivan Rascon-Aguilar

West Florida Division GME Research Day 2024

No abstract provided.

Biotin For Hair Loss: Teasing Out The Evidence, Allyson Yelich, Hannah Jenkins, Sara Holt, Richard Miller

West Florida Division GME Research Day 2024

No abstract provided.

Cemiplimab-Induced Hhs-Dka In A Patient Being Treated For Cutaneous Squamous Cell Carcinoma, Alexander Pyronneau, Kelvin Noronha, Amanda Zucker, Rachel Kennett

West Florida Division GME Research Day 2024

No abstract provided.

An Ear-Itating Infection, Sakshi Agarwal, J Burton Banks

South Atlantic Division GME Research Day 2024

No abstract provided.

Role Of Plasmapheresis: A Tale Of Two Thyroid Storms, Zhiwei Zhang, Sam Joseph, Donald Eagerton

South Atlantic Division GME Research Day 2024

No abstract provided.

Epigastric Abdominal Pain In Adult Secondary To Gastric Duplication Cysts And Bifid Pancreas: An Uncommon Coexistence, Brenna Casey, Himani Patel, James Garber

South Atlantic Division GME Research Day 2024

No abstract provided.

Navigating Social Media In Healthcare: Implications, Challenges, And Guidelines For Physicians, Charles F. Clinton, Logan Brown, Bhuvaneshwari Muchandi, José Ignacio González Martínez, Candler Boyett

South Atlantic Division GME Research Day 2024

No abstract provided.

Cured By Time? Exploring The Complexity Of Diagnosing Acute Encephalopathy, Charles F. Clinton, Avery Stokes, Candler Boyett, Bhuvaneshwari Muchandi, Mario E. Gonzalez

South Atlantic Division GME Research Day 2024

No abstract provided.

Nas Associated With Antenatal Tianeptine Exposure: A Case Report, Francesca Damus, Kaleb Freeman, Candace Murbach, Palmer Johnston

South Atlantic Division GME Research Day 2024

No abstract provided.