Medicine and Health Sciences Commons^™

Global Benchmarks In Primary Robotic Bariatric Surgery Redefine Quality Standards For Roux-En-Y Gastric Bypass And Sleeve Gastrectomy, Guillaume Giudicelli, Daniel Gero, Lind Romulo, Vasu Chirumamilla, Pouya Iranmanesh, Christopher K Owen, Wayne Bauerle, Amador Garcia, Lisa Lucas, Anne-Sophie Mehdorn, Dhananjay Pandey, Abdullah Almuttawa, Francisco Cabral, Abhishek Tiwari, Virginia Lambert, Beniamino Pascotto, Celine De Meyere, Marouan Yahyaoui, Thomas Haist, Oliver Scheffel, Maud Robert, Frederiek Nuytens, Santiago Azagra, Lilian Kow, Arun Prasad, Carlos Vaz, Michel Vix, Vivek Bindal, Jan H Beckmann, David Soussi, Ramon Vilallonga, Maher El Chaar, Erik B Wilson, Arif Ahmad, Andre Teixeira, Monika E Hagen, Christian Toso, Pierre-Alain Clavien, Milo Puhan, Marco Bueter, Minoa K Jung

Faculty, Staff and Student Publications

BACKGROUND: Whether the benefits of the robotic platform in bariatric surgery translate into superior surgical outcomes remains unclear. The aim of this retrospective study was to establish the 'best possible' outcomes for robotic bariatric surgery and compare them with the established laparoscopic benchmarks.

METHODS: Benchmark cut-offs were established for consecutive primary robotic bariatric surgery patients of 17 centres across four continents (13 expert centres and 4 learning phase centres) using the 75th percentile of the median outcome values until 90 days after surgery. The benchmark patients had no previous laparotomy, diabetes, sleep apnoea, cardiopathy, renal insufficiency, inflammatory bowel disease, immunosuppression, …

Mir126-Targeted-Nanoparticles Combined With Pi3k/Akt Inhibitor As A New Strategy To Overcome Melanoma Resistance, Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli

Faculty, Staff and Student Publications

Metastatic melanoma poses significant challenges as a highly lethal disease. Despite the success of molecular targeting using BRAFV600E inhibitors (BRAFis) and immunotherapy, the emergence of early recurrence remains an issue and there is the need for novel therapeutic approaches. This study aimed at creating a targeted delivery system for the oncosuppressor microRNA 126 (miR126) and testing its effectiveness in combination with a phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT) inhibitor for treating metastatic melanoma resistant to BRAFis. To achieve this, we synthesized chitosan nanoparticles containing a chemically modified miR126 sequence. These nanoparticles were further functionalized with an antibody specific to …

Impact Of Opioid-Free Analgesia On Pain Severity And Patient Satisfaction After Discharge From Surgery: Multispecialty, Prospective Cohort Study In 25 Countries, Tasman Collaborative

Faculty, Staff and Student Publications

BACKGROUND: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.

METHODS: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview …

Class Ii Hla-Drb4 Is A Predictive Biomarker For Survival Following Immunotherapy In Metastatic Non-Small Cell Lung Cancer, Cindy Y Jiang, Lili Zhao, Michael D Green, Shashidhar Ravishankar, Andrea M H Towlerton, Anthony J Scott, Malini Raghavan, Matthew F Cusick, Edus H Warren, Nithya Ramnath

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICI) are important treatment options for metastatic non-small cell lung cancer (mNSCLC). However, not all patients benefit from ICIs and can experience immune-related adverse events (irAEs). Limited understanding exists for germline determinants of ICI efficacy and toxicity, but Human Leukocyte Antigen (HLA) genes have emerged as a potential predictive biomarker. We performed HLA typing on 85 patients with mNSCLC, on ICI therapy and analyzed the impact of HLA Class II genotype on progression free survival (PFS), overall survival (OS), and irAEs. Most patients received pembrolizumab (83.5%). HLA-DRB4 genotype was seen in 34/85 (40%) and its presence correlated …

Group Reflection: Barrier Of The White Coat, Abrielle Fretz, Anusha Vavilikolanu, Cassandra Pecarski, Daphne Pate, Peter Nolan, Trisha Ray, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Patient Scheduling, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Gabrielle Cowen, Kassim Salami, Simran Brar, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Administrators: Scheduling Conflicts With Administration, Constance Cleveland, Deepa Raghavan, Dipra Debnath, Jay Maixner, Ranya Krayem, Vikash Mehan, Zane Mustafa, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administrator Makes An Offensive Or Inappropriate Comment, Emily Smith, Joseph Mccormick, Lukas Biel, Melissa Elmali, Mura Abdul-Nabi, Nitya Deshpande, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Administrators: Excused Absence Policy, Ashley Frei, Cameron Bear, Grant Zydeck, Justin Hassen, Madison Meyer, Mithil Gudi, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Professionalism Conflict With Administrator, Jessica Long, Jovan Jande, Krishni Kumaresan, Mohammad Al-Hadidi, Molly Dahle, Trevor Ruesch, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Scheduling Conflicts In The Workplace, Alisha Williams, Hovhannes Hayrapetyan, John Gallagher, Julia Malewicz, Kirsten Brinkmeier, Nasser Junedi, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Conflict Resolution And Professionalism, Abrielle Fretz, Anusha Vavilikolanu, Cassandra Pecarski, Daphne Pate, Peter Nolan, Trisha Ray, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Dissemination Of Information, Chase Aaron, Max Jones, Arhan Shetty, Ingrid Rocha, Jane Dow, Karamoja Monchamp, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Admin Will Not Cover A Procedure, Anthony Bally, Manahil Shaikh, Nadeen Sukhon, Petar Martinovski, Sarah Chamdin, Yousif Jafar, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Harassment In The Workplace, Alexander Minos, Carline Dugue, Ethan Mathew, Katherine Sommers, Lauren Fleckenstein, Peter Zakaria, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Staffing Concerns, Noor Sulaiman, Emma Breukink, Hussein Bazzi, Ranganath Kathawate, Ron Lukose, Vikram Rajan, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Conflict Resolution Approaching Admin, Amjad El Othmani, Bethany Lyche, Hafsah Umerani, Issac Anderson, Katie Clark, Nikhil Navathe, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Different Generations, Abbie Bauer, Anna Rowell, Joseph Wun, Kiersten Walsworth, Parker Fitzgerald, Peter Martin, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administrators Fail To Communicate, Anjani Raja, Armaan Naghdi, Blaise Deschamps, Jack Mao, Noor Sulieman, Stephanie Barna, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Violation Of Hippa, Michael Wang, Alexander Eskandarian, Grace Markey, Hamza Ali, Sesilia Kammo, Sonja Klumpp, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Time Off Conflict, Demetrius Moncrease, Parshva Salvi, Basel Mhaimeed, Fadumo Yusuf, Marissa Yaldo, Sneha Bhargava, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.

Conflict With Administrators: Receiving Negative Feedback From An Administrator, Saachi Mittal, Arifbillah Sarowar, Connor Sakis, Karthik Babu Kolisetty, Markiesha Baines, Meaghan Osborne, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Inappropriate Comment, Akarsh Lal, Damian Daryl Nucum, Elizabeth Choi, Emily Falkowski, Ramneet Chauhan, Shawn O'Malley, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Lack Of Communication, Abigail Jaczkowski, Angie Achkar, Brandon Doan, Diana Mcmahon, Julian Johnson, Kevin Tran, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Roles And Responsibilities, Alyssa Rogers, James Burtka, Kaitlin Verkuilen, Maria Tjilos, Nelson Pinto, Siddharth Tirumala, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Disagreement Over Patient Quotas, Era Cobani, Angelica Cabatu, Carly Abrahams, Curtis Mack, Michal Ruprecht, Nicholas Apostolakis, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Medical Supplies And Patient Care, Sujit Prasad, Ahmad Khatib, Dana Josifoski, Joyce Li, Kevin Cobty, Sarah Bdeir, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.

Conflict With Administrators: Addressing Negative Evaluations, Derya Turk, Izma Khaliq, Katherine Gavagan, Morolayo Ilori, Nabeel Sumbal, Srikanth Pillai, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Effecting Quality Patient Care, Dhiraj Tadikamalla, Lara Rostomian, Meet Patel, Neil Garg, Sara Naessig, Sohini Pandit, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Surgery Under The Influence, David Allen, Elena Busuito, Emma Burke, Rebekah Pitpitan, Rubi Walker, Zachary Chen, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.