Medicine and Health Sciences Commons^™

Determining The Value Proposition Of Surgical Care In Cms Star Rated Hospitals, Konrad Cios, Hanroo Janjua, Michael Rogers, Meagan Read, Salvatore Docimo, Paul Kuo

USF-LVHN SELECT

No abstract provided.

Process Improvements For The Treatment Of Iron Deficiency Anemia In Pregnancy, Iris Kong Md, Natalie Chlus Md, Bradley Lash Md

USF-LVHN SELECT

No abstract provided.

Implementation Of A Prediabetes Decision Aid In Primary Care, Lindsay Kim Md, Beth Careyva M.D., Autumn Kieber-Emmons Md, Mph, Nicole M. Burgess Bs, Roya Hamadani Mph, Aashka Patel

USF-LVHN SELECT

No abstract provided.

Enhancing Trauma Patient Outcomes Through The Implementation Of An Acute Care Surgery Service Program, Clara Freedman Md, Joseph J. Stirparo Md

USF-LVHN SELECT

No abstract provided.

Effect Of Implementation Of Mobility Partner In Post-Operative Trauma Surgery Patients In Local Community Hospital, Samantha Finkelstein Md, Joseph J. Stirparo Md

USF-LVHN SELECT

No abstract provided.

The Attitude Of Medical Students Toward Lgbtq Older Adults Before And After Intervention, Suzanna S Tom Md, Lynn M. Wilson Do

USF-LVHN SELECT

No abstract provided.

Substance Use In Homeless Adolescents During The Covid-19 Pandemic, Evanie Huang Md, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.

Sweet Dreams: Reducing Unnecessary Night-Time Interruptions For Vital Sign Checks In Low-Risk Adult Patients, Arthur A Ter-Zakarian Md, Amy Slenker Md, Zhe Chen Md

USF-LVHN SELECT

No abstract provided.

Sex Differences In Brain Mri Of Patients With Migraines, Y Su, S Singh, Victoria Qizhi Tay Md, Vitaliy Koss Md, Megan Leary Md, Hope Kincaid Mph, Cph, Hussam A. Yacoub Md, John Castaldo Md

USF-LVHN SELECT

No abstract provided.

Efficacy And Safety Of Rezafungin And Caspofungin In Candidaemia And Invasive Candidiasis: Pooled Data From Two Prospective Randomised Controlled Trials, George R Thompson 3rd, Marin Kollef, Et Al.

2020-Current year OA Pubs

BACKGROUND: Rezafungin, a new US Food and Drug Administration-approved, long-acting echinocandin to treat candidaemia and invasive candidiasis, was efficacious with a similar safety profile to caspofungin in clinical trials. We conducted pooled analyses of the phase 2 STRIVE and phase 3 ReSTORE rezafungin trials.

METHODS: ReSTORE was a multicentre, double-blind, double-dummy, randomised phase 3 trial conducted at 66 tertiary care centres in 15 countries. STRIVE was a multicentre, double-blind, double-dummy, randomised phase 2 trial conducted at 44 centres in 10 countries. Adults (≥18 years) with candidaemia or invasive candidiasis were treated with once-a-week intravenous rezafungin (400 mg and 200 mg) …

Multi-View Representation Learning For Tabular Data Integration Using Inter-Feature Relationships, Sandhya Tripathi, Bradley A Fritz, Mohamed Abdelhack, Michael S Avidan, Yixin Chen, Christopher R King

2020-Current year OA Pubs

OBJECTIVE: An applied problem facing all areas of data science is harmonizing data sources. Joining data from multiple origins with unmapped and only partially overlapping features is a prerequisite to developing and testing robust, generalizable algorithms, especially in healthcare. This integrating is usually resolved using meta-data such as feature names, which may be unavailable or ambiguous. Our goal is to design methods that create a mapping between structured tabular datasets derived from electronic health records independent of meta-data.

METHODS: We evaluate methods in the challenging case of numeric features without reliable and distinctive univariate summaries, such as nearly Gaussian and …

Professional Responsibility, Nurses, And Conscientious Objection: A Framework For Ethical Evaluation, Pamela J. Grace, Elizabeth Peter, Vicki D. Lachman, Norah L. Johnson, Deborah J. Kenny, Lucia D. Wocial

College of Nursing Faculty Research and Publications

Conscientious objections (CO) can be disruptive in a variety of ways and may disadvantage patients and colleagues who must step-in to assume care. Nevertheless, nurses have a right and responsibility to object to participation in interventions that would seriously harm their sense of integrity. This is an ethical problem of balancing risks and responsibilities related to patient care. Here we explore the problem and propose a nonlinear framework for exploring the authenticity of a claim of CO from the perspective of the nurse and of those who must evaluate such claims. We synthesized the framework using Rest’s Four Component Model …

Estimating The Treatment And Prophylactic Economic Value Of New Antimicrobials In Managing Antibiotic Resistance And Serious Infections For Common Pathogens In The Usa: A Population Modelling Study, Jason Gordon, Maria Gheorghe, Cale Harrison, Ryan Miller, James Dennis, Lotte Steuten, Simon Goldenberg, Sumanth Gandra, Amer Al-Taie

2020-Current year OA Pubs

BACKGROUND: Antimicrobial resistance is a growing public health concern. There is a global need to estimate the population-level value of developing new antimicrobials and to ensure the effective use of existing antimicrobials as strategies to counteract antimicrobial resistance. To this aim, population-level value criteria need to be considered alongside conventional value measures.

OBJECTIVE: The objective of this study was to develop a novel modelling approach to estimate the value of new antimicrobials, considering the transmission, diversity and enablement elements of STEDI value.

METHODS: We developed a population-based mathematical model for the assessment of antimicrobial value considering both prophylactic use of …

Causal Relationships Between Pain, Medical Treatments, And Knee Osteoarthritis: A Graphical Causal Model To Guide Analyses, Haadiya Cheema, Robert Brophy, Jamie Collins, Charles L Cox, Ali Guermazi, Mahima Kumara, Bruce A Levy, Lindsey Macfarlane, Lisa A Mandl, Robert Marx, Faith Selzer, Kurt Spindler, Jeffrey N Katz, Eleanor J Murray

2020-Current year OA Pubs

OBJECTIVE: Randomized controlled trials (RCTs) are a gold standard for estimating the benefits of clinical interventions, but their decision-making utility can be limited by relatively short follow-up time. Longer-term follow-up of RCT participants is essential to support treatment decisions. However, as time from randomization accrues, loss to follow-up and competing events can introduce biases and require covariate adjustment even for intention-to-treat effects. We describe a process for synthesizing expert knowledge and apply this to long-term follow-up of an RCT of treatments for meniscal tears in patients with knee osteoarthritis (OA).

METHODS: We identified 2 post-randomization events likely to impact accurate …

Technical Note: Minimizing Cied Artifacts On A 0.35 T Mri-Linac Using Deep Learning, Austen N Curcuru, Deshan Yang, Hongyu An, Phillip S Cuculich, Clifford G Robinson, H Michael Gach

2020-Current year OA Pubs

BACKGROUND: Artifacts from implantable cardioverter defibrillators (ICDs) are a challenge to magnetic resonance imaging (MRI)-guided radiotherapy (MRgRT).

PURPOSE: This study tested an unsupervised generative adversarial network to mitigate ICD artifacts in balanced steady-state free precession (bSSFP) cine MRIs and improve image quality and tracking performance for MRgRT.

METHODS: Fourteen healthy volunteers (Group A) were scanned on a 0.35 T MRI-Linac with and without an MR conditional ICD taped to their left pectoral to simulate an implanted ICD. bSSFP MRI data from 12 of the volunteers were used to train a CycleGAN model to reduce ICD artifacts. The data from the …

Impact Of Diagnostic Stewardship Interventions In The Collection Process Of Fungal Blood Cultures, Miguel A Chavez, Satish Munigala, Carey-Ann D Burnham, Melanie L Yarbrough, Crystal Squires, Josephine Fox, Heather Gasama, Kevin Hsueh, David K Warren

2020-Current year OA Pubs

We implemented 2 interventions to improve utilization and contamination at our institution: kits to improve appropriate sample collection and an electronic order alert displaying appropriate indications of fungal blood cultures. An electronic order alert when ordering fungal blood cultures was associated with decreased utilization without decrease in positivity rate.

Hypoimmune Induced Pluripotent Stem Cells Survive Long Term In Fully Immunocompetent, Allogeneic Rhesus Macaques, Xiaomeng Hu, Nathaniel J Hogrebe, Et Al.

2020-Current year OA Pubs

Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient's immune system would abolish the requirement for immunosuppressive drugs or encapsulation and support large-scale manufacturing of off-the-shelf cell products. Previously, we generated mouse and human hypoimmune pluripotent (HIP) stem cells by depleting HLA class I and II molecules and overexpressing CD47 (B2M

Distributed Feature Representations Of Natural Stimuli Across Parallel Retinal Pathways, Jen-Chun Hsiang, Ning Shen, Florentina Soto, Daniel Kerschensteiner

2020-Current year OA Pubs

How sensory systems extract salient features from natural environments and organize them across neural pathways is unclear. Combining single-cell and population two-photon calcium imaging in mice, we discover that retinal ON bipolar cells (second-order neurons of the visual system) are divided into two blocks of four types. The two blocks distribute temporal and spatial information encoding, respectively. ON bipolar cell axons co-stratify within each block, but separate laminarly between them (upper block: diverse temporal, uniform spatial tuning; lower block: diverse spatial, uniform temporal tuning). ON bipolar cells extract temporal and spatial features similarly from artificial and naturalistic stimuli. In addition, …

The Conceptual Definition Of Sarcopenia: Delphi Consensus From The Global Leadership Initiative In Sarcopenia (Glis), Ben Kirk, Ellen F Binder, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on the definition exists.

OBJECTIVE: The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing the global conceptual definition of sarcopenia.

DESIGN: The GLIS steering committee was formed in 2019-21 with representatives from all relevant scientific societies worldwide. During this time, the steering committee developed a set of statements on the topic and invited members from these societies to participate in a two-phase International Delphi Study. Between 2022 and 2023, participants ranked their agreement with a set of …

Genome And Clonal Hematopoiesis Stability Contrasts With Immune, Cfdna, Mitochondrial, And Telomere Length Changes During Short Duration Spaceflight, J Sebastian Garcia-Medina, Irenaeus Chan, Carlos Cruchaga, Kelly Bolton, Et Al.

2020-Current year OA Pubs

BACKGROUND: The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation to spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure.

METHODS: To provide a detailed genetics analysis of the mission, we collected dried blood spots pre-, during, and post-flight for DNA extraction. Telomere length was measured by quantitative PCR, while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations. A robust bioinformatic pipeline was used for data analysis, including variant calling to …

Long-Term Outcomes Of Patients With Large B-Cell Lymphoma Treated With Axicabtagene Ciloleucel And Prophylactic Corticosteroids, Olalekan O Oluwole, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

ZUMA-1 safety management cohort 6 investigated the impact of prophylactic corticosteroids and earlier corticosteroids and/or tocilizumab on the incidence and severity of cytokine release syndrome (CRS) and neurologic events (NEs) following axicabtagene ciloleucel (axi-cel) in patients with relapsed/refractory large B-cell lymphoma (R/R LBCL). Prior analyses of cohort 6 with limited follow-up demonstrated no Grade ≥3 CRS, a low rate of NEs, and high response rates, without negatively impacting axi-cel pharmacokinetics. Herein, long-term outcomes of cohort 6 (N = 40) are reported (median follow-up, 26.9 months). Since the 1-year analysis (Oluwole, et al. Blood. 2022;138[suppl 1]:2832), no new CRS was reported. …

Biomarker-Directed Targeted Therapy Plus Durvalumab In Advanced Non-Small-Cell Lung Cancer: A Phase 2 Umbrella Trial, Benjamin Besse, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

For patients with non-small-cell lung cancer (NSCLC) tumors without currently targetable molecular alterations, standard-of-care treatment is immunotherapy with anti-PD-(L)1 checkpoint inhibitors, alone or with platinum-doublet therapy. However, not all patients derive durable benefit and resistance to immune checkpoint blockade is common. Understanding mechanisms of resistance-which can include defects in DNA damage response and repair pathways, alterations or functional mutations in STK11/LKB1, alterations in antigen-presentation pathways, and immunosuppressive cellular subsets within the tumor microenvironment-and developing effective therapies to overcome them, remains an unmet need. Here the phase 2 umbrella HUDSON study evaluated rational combination regimens for advanced NSCLC following failure of …

Cystic And Atrophic Kidneys, Atrophic Pancreas, Arcuate Uterus, And Diabetes Mellitus Associated With Deletion Of Hnf1Β Gene, Rachel L Usala, Alberto Sobrero, Amy Riek, Janet Mcgill, Fumihiko Urano

2020-Current year OA Pubs

No abstract provided.

Body Size And Risk Of Colorectal Cancer Molecular Defined Subtypes And Pathways: Mendelian Randomization Analyses, Nikos Papadimitriou, Yin Cao, Et Al.

2020-Current year OA Pubs

BACKGROUND: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain.

METHODS: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations). Summary data on tumour markers were obtained from two genetic consortia (CCFR, GECCO).

FINDINGS: A 1-standard deviation (SD:5.1 kg/m

INTERPRETATION: Body size was more strongly …

Once-Daily Oral Berotralstat For Long-Term Prophylaxis Of Hereditary Angioedema: The Open-Label Extension Of The Apex-2 Randomized Trial, Sorena Kiani-Alikhan, H James Wedner, Et Al.

2020-Current year OA Pubs

BACKGROUND: Berotralstat is a first-line, once-daily oral plasma kallikrein inhibitor approved for prophylaxis of hereditary angioedema (HAE) attacks in patients 12 years or older.

OBJECTIVE: This analysis examined the safety and effectiveness of long-term prophylaxis with berotralstat.

METHODS: APeX-2 was a phase 3, parallel-group, multicenter trial in patients with HAE caused by C1-inhibitor deficiency (NCT03485911). Part 1 was a randomized, double-blind, placebo-controlled evaluation of 150 and 110 mg of berotralstat over 24 weeks. In part 2, berotralstat-treated patients continued the same treatment, and placebo-treated patients were re-randomized to 150 or 110 mg of berotralstat for 24 weeks. In part 3, …

Clinical Variants Paired With Phenotype: A Rich Resource For Brain Gene Curation, Maya Chopra, Virginia Lanzotti, Dustin Baldridge, Christina A Gurnett, Philip R O Payne, Et Al.

2020-Current year OA Pubs

PURPOSE: Clinically ascertained variants are under-utilized in neurodevelopmental disorder research. We established the Brain Gene Registry (BGR) to coregister clinically identified variants in putative brain genes with participant phenotypes. Here, we report 179 genetic variants in the first 179 BGR registrants and analyze the proportion that were novel to ClinVar at the time of entry and those that were absent in other disease databases.

METHODS: From 10 academically affiliated institutions, 179 individuals with 179 variants were enrolled into the BGR. Variants were cross-referenced for previous presence in ClinVar and for presence in 6 other genetic databases.

RESULTS: Of 179 variants …

Cell-Specific Systemic Immune Signatures Associated With Treatment Burden In Neovascular Age-Related Macular Degeneration, Joseph B Lin, Andrea Santeford, Darksha Usmani, Aaditya V Shah, Philip A Ruzycki, Rajendra S Apte

2020-Current year OA Pubs

PURPOSE: Choroidal neovascularization (CNV) accounts for the majority of severe vision loss in neovascular age-related macular degeneration (AMD). Despite therapies that target VEGF, patients are often under-responsive, require frequent eye injections to control disease, and eventually lose some vision despite chronic therapy implicating a multifactorial etiology in treatment response. Genetic studies implicate systemic immunity in AMD and systemic immune cells accumulate within CNV lesions, yet a role for these cells in anti-VEGF response remains undetermined. The purpose of this study was to identify transcriptional signatures of circulating immune cells that are associated with high anti-VEGF treatment burden.

DESIGN: Experimental pilot …

Scoring System For Prediction Of Overall Survival In Patients With Renal Cell Carcinoma T3an0m0, Caio Vinícius Suartz, Maurício Dener Cordeiro, Paulo Afonso De Carvalho, Fábio Pescarmona Gallucci, Leopoldo Alves Ribeiro-Filho, Leonardo Cardili, Arjun Sivaraman, François Audenet, José Mauricio Mota, William Carlos Nahas

2020-Current year OA Pubs

OBJECTIVE: We aim to create a new score to predict postoperative overall survival in patients with nonmetastatic T3aN0 renal cell carcinoma.

METHODS: We reviewed the clinical data of adult patients who underwent radical nephrectomy for renal cell carcinoma between December 2007 and January 2022 in a single tertiary oncological institution. Clinical characteristics, clinical-pathological staging and histopathological characteristics were analysed. Survival analyses were determined using the Kaplan-Meier curve. A nomogram was established using Cox proportional hazard regression to identify the prognostic factors affecting the overall survival. The area under the curve, calibration curves and decision curve analysis were used to evaluate …

Comparing Bladder Neck Contracture Rate Between Robotic Intracorporeal And Extracorporeal Neobladder Construction, Rohit Bhatt, Dylan J. Mittauer, Joel M. Vetter, Nimrod S. Barashi, Riley Mcginnis, Kenneth G. Sands, Alexander K. Chow, Eric H. Kim

2020-Current year OA Pubs

Robot-assisted radical cystectomy (RARC) has become more accessible to surgeons worldwide, and descriptions of intracorporeal urinary diversion techniques, such as orthotopic neobladder construction, have increased. In this study, we aim to compare the rate of bladder neck contracture (BNC) formation between RARC and two different urinary diversion techniques. We retrospectively reviewed our institutional database for patients with bladder cancer who underwent RARC with intracorporeal neobladder (ICNB) construction (n = 11) or extracorporeal neobladder (ECNB) construction (n = 11) between 2012 and 2020. BNC was defined by the need for an additional surgical procedure (e.g., dilatation, urethrotomy). Patients who underwent RARC …

Altered Larval Activation Response Associated With Multidrug Resistance In The Canine Hookworm Ancylostoma Caninum, Elise L Mckean, Emilia Grill, Young-Jun Choi, Makedonka Mitreva, Damien M O'Halloran, John M Hawdon

2020-Current year OA Pubs

Parasitic gastrointestinal nematodes pose significant health risks to humans, livestock, and companion animals, and their control relies heavily on the use of anthelmintic drugs. Overuse of these drugs has led to the emergence of resistant nematode populations. Herein, a naturally occurring isolate (referred to as BCR) of the dog hookworm,