Medicine and Health Sciences Commons^™

Associations Between Anemia And Fgf23 In The Ckid Study., Elizabeth Thomas, Alexandra M. Klomhaus, Marciana L. Laster, Susan L. Furth, Bradley A. Warady, Isidro B. Salusky, Mark R. Hanudel

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that plays a central role in chronic kidney disease-mineral bone disorder and is associated with CKD progression and cardiovascular morbidity. Factors related to CKD-associated anemia, including iron deficiency, can increase FGF23 production. This study aimed to assess whether anemia and/or iron deficiency are associated with increased circulating concentrations of FGF23 in the large, well-characterized Chronic Kidney Disease in Children (CKiD) study cohort.

METHODS: Hemoglobin concentrations, iron parameters, C-terminal (total) FGF23, intact FGF23, and relevant covariables were measured in cross-sectional analysis of CKiD study subjects.

RESULTS: In 493 pediatric patients with …

Real-World Evidence On The Dosing And Safety Of C.E.R.A. In Pediatric Dialysis Patients: Findings From The International Pediatric Dialysis Network Registries., Laura Kohlhas, Milena Studer, Loes Rutten-Jacobs, Sylvie Meyer Reigner, Anja Sander, Hui-Kim Yap, Karel Vondrak, Paula A. Coccia, Francisco Cano, Claus Peter Schmitt, Bradley A. Warady, Franz Schaefer, Ipdn Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: This retrospective real-world study used data from two registries, International Pediatric Peritoneal Dialysis Network (IPPN) and International Pediatric Hemodialysis Network (IPHN), to characterize the efficacy and safety of continuous erythropoietin receptor activator (C.E.R.A.) in pediatric patients with chronic kidney disease (CKD) on peritoneal dialysis (PD) or hemodialysis (HD).

METHODS: IPPN and IPHN collect prospective data (baseline and every 6 months) from pediatric PD and HD centers worldwide. Demographics, clinical characteristics, dialysis information, treatment, laboratory parameters, number and causes of hospitalization events, and deaths were extracted for patients on C.E.R.A. treatment (IPPN: 2007-2021; IPHN: 2013-2021).

RESULTS: We analyzed 177 patients …

Remote Delivery Of Allied And Behavioral Healthcare During Covid-19 For Children With Developmental Disabilities., Lisa D. Wiggins, Lin H. Tian, Sarah C. Tinker, Marshalyn Yeargin-Allsopp, Carolyn G. Diguiseppi, Cy Nadler, Patrick S. Powell, Eric J. Moody, Maureen S. Durkin, M Danielle Fallin, A Blythe Ryerson, Joann M. Thierry, Britney Robinson, Karen Pazol

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Many children with autism spectrum disorder (ASD) and other developmental disabilities (DD) transitioned to telehealth services due to the COVID-19 pandemic. Our objectives were to describe reductions in allied and behavioral healthcare services and receipt of caregiver training to deliver services at home because of COVID-19 for children with ASD and other DD, and factors associated with worse response to remote delivery of services for children with ASD.

METHOD: Prior to the pandemic, children 2 to 5 years of age were enrolled in a multi-site case-control study and completed a developmental assessment. Caregivers completed questionnaires on child behavior problems …

Racial And Ethnic Disparities In The Co-Occurrence Of Intellectual Disability And Autism: Impact Of Incorporating Measures Of Adaptive Functioning., Sarah M. Furnier, Ronald Gangnon, Julie L. Daniels, Susan Ellis Weismer, Cy Nadler, Karen Pazol, Nuri M. Reyes, Steven Rosenberg, Eric Rubenstein, Lisa D. Wiggins, Marshalyn Yeargin-Allsopp, Maureen S. Durkin

Manuscripts, Articles, Book Chapters and Other Papers

Intellectual disability (ID) commonly co-occurs in children with autism. Although diagnostic criteria for ID require impairments in both cognitive and adaptive functioning, most population-based estimates of the frequency of co-occurring ID in children with autism-including studies of racial and ethnic disparities in co-occurring autism and ID-base the definition of ID solely on cognitive scores. The goal of this analysis was to examine the effect of including both cognitive and adaptive behavior criteria on estimates of co-occurring ID in a well-characterized sample of 2- to 5-year-old children with autism. Participants included 3264 children with research or community diagnoses of autism enrolled …

Retrospective Cohort Study Of Pure Tone Audiometry Hearing Changes From Ototoxic Metalsand Solvents, Continuous Noise, And Impulse Noise Exposures At Hill Air Force Base From 2005 To 2019, Zachary I. Johnson

Theses and Dissertations

This retrospective cohort epidemiological study investigated the relative risks of hearing loss associated with ototoxicants in combination with noise exposure. Utilizing Department of Defense (DoD) industrial hygiene and hearing conservation data, this research expanded on a 2020 thesis conducted on Tinker Air Force Base (AFB), applying a similar methodology to Hill AFB, adding 893 evaluated individuals. Grouped into twelve exposure combinations with a minimum of three years of exposure duration, the study assessed various hearing loss indicators, including DoD Standard Threshold Shift (STS) and NIOSH STS. Ototoxic substances consistently elevated relative risk (RR) compared to noise-only exposure groups, but none …

An Investigation Of Torso Muscle Fatigue And Its Relation To Discomfort During Vertical Vibration Exposure, Nathan H. Hodges

Theses and Dissertations

Military and civilian helicopter pilots often experience back pain attributed to vibration exposure during flight and sustained poor posture, known as the "helicopter hunch." This study investigated torso muscle activation using surface electromyography (EMG) to assess the relationship between discomfort and muscle fatigue. Eight subjects were exposed to different vibration frequencies over two-hour periods, with EMG data collected every five minutes. Significant differences in muscle activation were observed before and after vibration exposure, suggesting increased muscle activation during vibration compared to prolonged seating alone. Discomfort surveys indicated higher discomfort during vibration.

Extracellular Domain Mutations Of The Egf Receptor Differentially Modulate High-Affinity And Low-Affinity Responses To Egf Receptor Ligands, Jennifer L Macdonald-Obermann, Linda J Pike

2020-Current year OA Pubs

The EGF receptor is mutated in a number of cancers. In most cases, the mutations occur in the intracellular tyrosine kinase domain. However, in glioblastomas, many of the mutations are in the extracellular ligand binding domain. To determine what changes in receptor function are induced by such extracellular domain mutations, we analyzed the binding and biological response to the seven different EGF receptor ligands in three common glioblastoma mutants-R84K, A265V, and G574V. Our data indicate that all three mutations significantly increase the binding affinity of all seven ligands. In addition, the mutations increase the potency of all ligands for stimulating …

Does Vibrotactile Stimulation Of The Auricular Vagus Nerve Enhance Working Memory? A Behavioral And Physiological Investigation, Gansheng Tan, Josh Adams, Kara Donovan, Phillip Demarest, Jon T Willie, Peter Brunner, Jenna L Gorlewicz, Eric C Leuthardt

2020-Current year OA Pubs

BACKGROUND: Working memory is essential to a wide range of cognitive functions and activities. Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising method to improve working memory performance. However, the feasibility and scalability of electrical stimulation are constrained by several limitations, such as auricular discomfort and inconsistent electrical contact.

OBJECTIVE: We aimed to develop a novel and practical method, vibrotactile taVNS, to improve working memory. Further, we investigated its effects on arousal, measured by skin conductance and pupil diameter.

METHOD: This study included 20 healthy participants. Behavioral response, skin conductance, and eye tracking data were concurrently recorded while the …

Meniscal Radial Tears: A Classification System Based On Tear Morphology, Jorge Chahla, Derrick M Knapik, Harkirat Jawanda, Felicitas Allende, Horacio Rivarola, Johnathon R Mccormick, Robert F Laprade, Garrett R Jackson

2020-Current year OA Pubs

Appropriate management of radial meniscal tears is complex, with continued efforts focused on optimizing diagnostic methods for identification to help dictate treatment, especially as surgical indications for repair have expanded, coupled with improvements in surgical techniques and instrumentation. Currently, no standardized classification system for radial meniscal tears exists, limiting the ability to accurately characterize injury patterns and guide surgical decision-making.

Ensuring Intervention Fidelity Of An Attention Control Arm In A Multisite Randomized Controlled Trial, Amy R. Newman, Karen M. Moody, Kerri Becktell, Erin Connelly, Cynthia Holladay, Katie Parisio, Jonathan L. Powell, Verna L. Hendricks-Ferguson

College of Nursing Faculty Research and Publications

Background

Intervention fidelity is a critical element of randomized controlled trials, yet reporting of intervention fidelity among attention control arms is limited. Lack of fidelity to attention control procedures can affect study outcomes by either overestimating or underestimating the efficacy of the intervention under examination.

Objectives

This brief report describes the approach researchers took to promote fidelity to the attention control arm of a pediatric palliative care randomized controlled trial funded by the National Institutes of Health.

Methods

The Informational Meetings for Planning and Coordinating Treatment trial aims to determine the efficacy of a communication intervention that uses care team …

Associations Between Parenting Stress And Quality Time In Families Of Youth With Autism Spectrum Disorder, Rebecca S. Bradley, Grace L. Staples, Lauren B. Quetsch, Lindsey Aloia, Cynthia E. Brown, Stephen M. Kanne

Psychological Science Faculty Publications and Presentations

Increased stress among parents of youth with ASD has been well-documented. However, research on aspects of the parent-child relationship and subsequent links to parenting stress is limited. We assessed parents (N = 511) of youth with ASD to examine relations between parenting stress and parent-child quality time (amount of quality time, shared enjoyment, synchronicity). Elevated parenting stress was associated with less time spent engaging with youth in shared activities and decreased parent and child enjoyment during shared interactions. Parents with elevated stress reported engaging in shared activities and experiencing synchronicity with their child less often than parents below the …

Characterizing The Fulfillment Of And Barriers To Post-Partum Tubal Ligation At A Suburban Academic-Community Hospital, Carrie Wang Md, Joanne Quiñones Md, Msce, Dahlia Kronfli Md, Treasure N. Walker

USF-LVHN SELECT

No abstract provided.

Creating A Centralized Resource For Pediatric Pathology Cases, Shirley Jiang Md, Elsie S. Lee Md

USF-LVHN SELECT

No abstract provided.

Exploring Attitudes To Covid-19 Vaccination In A Rural Population, Nikhil C Reddy Md, Grant M. Greenberg M.D., M.H.S.A., M.A.

USF-LVHN SELECT

No abstract provided.

Feasibility Of Initiating A Screening, Testing, And Treatment Protocol For Pregnant Patients At High Risk For Obstructive Sleep Apnea (Osa), Kara Madey Md, Joanne Quiñones Md, Msce, Aileen L Love Md

USF-LVHN SELECT

No abstract provided.

Excellent Outcomes Of Atypical Fibroxanthoma Warrant Specific Diagnosis, Erin Mcclure Md, Michael Carr, Ayushi Y. Patel Md, Syed Mahrukh Hussnain Naqvi, Youngchul Kim, Michael Harrington, Wayne Cruse, Ricardo J. Gonzalez, Vernon Sondak, Amod Sarnaik, Jane Messina, Jonathan Zager

USF-LVHN SELECT

No abstract provided.

Reevaluating Surgical Interventions In Childbirth For Women With Arnold Chiari Malformation Type I: A Systematic Review, Shalom Mussa Md, Kathryn Cheponis Md

USF-LVHN SELECT

No abstract provided.

Clinical And Genomic Correlates With Genetic Ancestry In Lung Squamous Cell Carcinoma, Sejal Jain Md, Alexander Yao, Fatemeh Momen-Heravi, Diane Allen-Gipson, Xiaoyang Zhang, Jian Carrot-Zhang, Alison Taylor

USF-LVHN SELECT

No abstract provided.

Abortion Complications In The Post-Roe Era: An Academic Community Hospital Perspective, Morgan Mcfadden Md, Patricia L. Mara Md, Kristen Maiden Md, Hope Kincaid Mph, Cph

USF-LVHN SELECT

No abstract provided.

Differential Time From Diagnosis To Treatment Of Pulmonary Malignancy, Subin Paul Md, C. Gerard Petersen Md

USF-LVHN SELECT

No abstract provided.

Impacting Cervical Cancer Disparities In Hispanic Women In The Lehigh Valley, Melissa Sur Md, Autumn Kieber-Emmons Md, Mph

USF-LVHN SELECT

No abstract provided.

Examining The Roles Of Erythropoietin And Melatonin In Preventing The Development Of Post-Hemorrhagic Hydrocephalus Of Prematurity, Sindhu Ramachandra, Lauren L. Jantzie, Shenandoah Robinson

USF-LVHN SELECT

No abstract provided.

Participation In Amputation Support Group On The Morbidity And Mortality Of Lower Extremity Amputation Patients, Karthik Pittala Md, Weston Terrasse Md, Ahmed Mansour Md, Nathan F. Miller Md

USF-LVHN SELECT

No abstract provided.

Grapheme-Color Synesthesia In Patients With Epilepsy, Snow Pinxue Li Md, Atef Kokash Do, Martina Vendrame Md, Phd

USF-LVHN SELECT

No abstract provided.

Initiation Patterns Of Anticoagulants For Atrial Fibrillation Among Older Uk Adults With And Without Chronic Kidney Disease, 2010-2020, Deborah Liaw Md, Julia Liaw, Chintan Dave

USF-LVHN SELECT

No abstract provided.

Select Anesthesiology Interest Group Needs Assessment And Quality Improvement, Brett O'Donnell Md, Thomas A. Mcloughlin Md

USF-LVHN SELECT

No abstract provided.

Health Fairs: A Community-Based Approach To Improving Health-Seeking Behaviors And Building Trust In The Healthcare System Among Patients In The Lehigh Valley, Fawaz Hussain Md, Fatima Pasha Md, Jonaid Aslam Md

USF-LVHN SELECT

No abstract provided.

The Relationship Between Blood Pressure And The Development Of Preterm Birth And Preeclampsia, Akshar Patel, Autumn Kieber-Emmons Md, Mph, Ashwini Kamath Mulki, Kyle Shaak Bs

USF-LVHN SELECT

No abstract provided.

Improving Health Literacy In The Lehigh Valley: Assessing The Role Of Health Fairs In Providing Education And Enhancing Understanding Of Diabetes, Hypertension, And Colon Cancer Screening, Fatima Pasha Md, Fawaz Hussain Md, Jonaid Aslam Md

USF-LVHN SELECT

No abstract provided.

Implementing Pure Tone Audiometry Screening For Cochlear Implant Evaluation In The Community Setting, Kedar N Patel, Alicia Stanley Au.D., Sri Kiran Chennupati Md

USF-LVHN SELECT

No abstract provided.