Medicine and Health Sciences Commons^™

Shower Dehumidification To Reduce Nontuberculous Mycobacteria Aerosolization, Michael X. Kostecki, Yvonne L. Chan, Jennifer R. Honda

School of Medicine Faculty Publications and Presentations

Objective: Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause recalcitrant lung disease. Prior reports have demonstrated links between shower use and infections, yet the aerosolization of NTM from showerheads, as well as the humidity levels that may modulate NTM aerosolization from showerheads is less studied. The objective of the current study was to investigate the role of humidity in NTM aerosolization among showers in homes located in a geographic area with high lung disease incidence, Hawai’i, and test whether deployment of a dehumidifier in well-ventilated bathrooms reduce NTM exposure. Results: Across two sampling events and five showers, …

269 Years Of Homoeopathy: The Healing Continues, Subhash Kaushik

Indian Journal of Research in Homoeopathy

As we gear up to celebrate 269 years of homoeopathy, it is a matter of pride for the homoeopathic fraternity that homoeopathy continues to evolve globally. Homoeopathy is now a widely used medical system with over 200 million users in 100+ countries. If factors such as strong evidence, wide, global usage, and economic viability can be considered as the pillars that make a healthcare model legitimate for a nation, Homoeopathy, indeed, makes the cut. Given its well-acclaimed abilities of permanent, effective, and safe treatment, homoeopathy went on to be a fundamental part of Indian healthcare. However, despite the relevance and …

Safety Of Potentised Dilutions Of Rhus Toxicodendron In Wistar Albino Rats, Abanti Goswami, Narasimha Kumar Gv, Vara Prasad Saka, Pankaj Gupta, Bibaswan Biswas, Digvijay Verma

Indian Journal of Research in Homoeopathy

Background: Rhus toxicodendron (Rhus tox.) is a well-known homoeopathic medicine used to treat inflammatory disorders supported by historical and modern scientific evidence. Objective: The safety testing of 6C, 30C and 200C potencies of Rhus tox. through acute and sub-acute oral toxicity tests as per the Organisation for Economic Cooperation and Development test guidelines. Methods: For the acute oral toxicity study, Rhus tox. (2000 μL/kg) was administered to rats and observed for 14 days. For the subacute oral toxicity study, Rhus tox. (200 μL/kg) was administered for 28 days and additional recovery groups were included to monitor reversibility, persistence, or delayed …

Usage Of Arsenicum Album 30c As A Prophylactic Medicine In Healthcare Workers Of A Covid Health Centre – A Report, Rekha Thomas, Thankaraj Balakrishnan, Anu Rajesh, George Mathew, Saurabh Kumar Jain, Radhika Agarwal, Anu Kapoor

Indian Journal of Research in Homoeopathy

The homoeopathic medicine Arsenicum album 30C was recommended as prophylaxis by the Central Council for Research in Homoeopathy, along with general precautions during COVID-19 pandemic. A retrospective cohort study was conducted in Delhi, India, during May–August 2020 to evaluate the effectiveness of Arsenicum album 30C as prophylaxis for COVID-19 in a high-risk group of healthcare workers (HCWs). HCWs (n = 100) were categorised into two groups based on the number of days Arsenicum album 30C was administered during their duty: 7 days (N1 = 38) or 14 days (N2 = 62). Participants underwent COVID-19 testing (rapid antigen test/reverse transcriptase-polymerase chain …

Paediatric Cholelithiasis Treated With Homoeopathy: A Case Report, Girish Gupta

Indian Journal of Research in Homoeopathy

Introduction: Gallstones are formed due to the precipitation of components of bile in the lumen of the gallbladder. The incidence of gallstones is extremely rare in children and patients are mostly asymptomatic. However, biliary colic may occur due to reflexive smooth muscle spasm by the stone obstructing the bile duct and may be the presenting symptom in 50% of cases of paediatric cholelithiasis whereas 25% may have non-specific symptoms, 20% may be asymptomatic and 5–10% may have complicated symptoms. The conventional treatment of gallstones is surgery even in children, whereas homoeopathy can provide non-surgical treatment in such cases. Case …

Homoeopathic Treatment Of A Child With Internet Gaming Disorder And Atopic Dermatitis: A Case Report, Ashish Mahajan, Nidhi Mahajan, Anuradha Singh, Mohan Lal Chopra

Indian Journal of Research in Homoeopathy

Introduction: Internet gaming disorder (IGD) is an emerging disorder, recently added to DSM-5, which has a capacity to reach pandemic proportions in the near future. The Indian mobile gaming market has grown significantly over the past few years with many users spending a significant amount of time on mobile games. A patient initially presenting with atopic dermatitis (AD) was subsequently diagnosed with IGD based on the analysis of his mental symptoms and was managed holistically with homoeopathy. Case Summary: A 3-year-old boy primarily presented with AD. During the interrogation of his mental state, he was found to have …

Cancer Biomarkers: Emerging Trends And Clinical Implications For Personalized Treatment, Antonio Passaro, Maise Al Bakir, Emily G Hamilton, Maximilian Diehn, Fabrice André, Sinchita Roy-Chowdhuri, Giannis Mountzios, Ignacio I Wistuba, Charles Swanton, Solange Peters

Faculty, Staff and Student Publications

The integration of cancer biomarkers into oncology has revolutionized cancer treatment, yielding remarkable advancements in cancer therapeutics and the prognosis of cancer patients. The development of personalized medicine represents a turning point and a new paradigm in cancer management, as biomarkers enable oncologists to tailor treatments based on the unique molecular profile of each patient's tumor. In this review, we discuss the scientific milestones of cancer biomarkers and explore future possibilities to improve the management of patients with solid tumors. This progress is primarily attributed to the biological characterization of cancers, advancements in testing methodologies, elucidation of the immune microenvironment, …

Obstinate Chronic Venous Ulcer Treated With The Homoeopathic Medicine Silicea: A Case Report, Sumit Paliwal, Laijun Nahar

Indian Journal of Research in Homoeopathy

Introduction: Vascular leg ulcers are highly prevalent conditions that have difficult management, a high sanitary cost and an impact on the patient’s quality of life. Individualised homoeopathic treatment could be a safe and affordable therapeutic option for venous ulcers. Case Summary: A 35-year-old male was treated with homoeopathic medication for an intractable case of chronic venous ulcer. Individualised homoeopathic medicine, Silicea, was prescribed after thorough case-taking, which led to improvement in subjective and objective symptoms. The Modified Naranjo Criteria score was 8 following the homoeopathic treatment, which shows positive causal attribution of the individualised homoeopathic medicine Silicea in …

Tinea Cruris Managed With A Single Dose Of Individualised Homoeopathic Medicine: A Case Report, K Sivakumar

Indian Journal of Research in Homoeopathy

Introduction: Tinea cruris is an infection of the skin over groins by a species of dermatophyte. It is a common ringworm infestation that affects the groin and is caused by Trichophyton rubrum, characterised by red, itchy erythematous plaques extending from the Groin and flexures onto the thighs, buttocks and perianal region of the skin. More than eight million people visit primary care physicians annually to treat tinea-related symptoms. Topical agents are the mainstay in conventional medicine. However, a holistic approach with Homoeopathy for treating tinea cruris can make a difference in terms of both cure and preventing relapse. Case …

Research Highlights, Bhavna Makhija, Khan Sheeba Saleem

Indian Journal of Research in Homoeopathy

Research Highlights

Colorectal Cancer Survival Disparities In The Five Regions Of Georgia, Meng-Han Tsai, Daramola N. Cabral, Caitlyn Grunert, Justin X. Moore

Markey Cancer Center Faculty Publications

Background/objective

The objective of this study was to examine 5-year colorectal cancer survival rates. We also determined whether demographics, tumor characteristics, and treatment modality were associated with 5-year CRC survival in the Clayton, West Central, East Central, Southeast, and Northeast Georgia regions because the significant higher CRC mortality rates in these regions in comparison to the overall rates in the State of Georgia.

Methods

We conducted a retrospective cohort analysis using data from the 1975–2016 Surveillance, Epidemiology, and End Results program aggregated CRC patients to these five regions. Five-year CRC survival was calculated and stratified by the five regions of …

The Hagfish Genome And The Evolution Of Vertebrates, Ferdinand Marlétaz, Nataliya Timoshevskaya, Vladimir A. Timoshevskiy, Elise Parey, Oleg Simakov, Daria Gavriouchkina, Masakazu Suzuki, Kaoru Kubokawa, Sydney Brenner, Jeramiah James Smith, Daniel S. Rokhsar

Markey Cancer Center Faculty Publications

As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial window into early vertebrate evolution1–3 . Here we investigate the complex history, timing and functional role of genome-wide duplications4–7 and programmed DNA elimination8,9 in vertebrates in the light of a chromosome-scale genome sequence for the brown hagfish Eptatretus atami. Combining evidence from syntenic and phylogenetic analyses, we establish a comprehensive picture of vertebrate genome evolution, including an auto-tetraploidization (1RV) that predates the early Cambrian cyclostome–gnathostome split, followed by a mid–late Cambrian allo-tetraploidization (2RJV) in gnathostomes and a prolonged Cambrian–Ordovician hexaploidization (2RCY) in cyclostomes. Subsequently, hagfishes underwent …

Association Of Nightly Fasting, Meal Frequency, And Skipping Meals With Metabolic Syndrome Among Kuwaiti Adults, Fatema Alkhulaifi, Suad Al-Hooti, Sameer Al-Zenki, Husam Alomirah, Qian Xiao, Wenyaw Chan, Fuqing Wu, Charles Darkoh

Faculty, Staff and Student Publications

Mounting evidence suggests that meal timing and frequency are associated with cardiometabolic health by influencing circadian rhythms. However, the evidence is inconsistent and limited, especially in non-Western cultures. This cross-sectional study aims to investigate the association between temporal habits of dietary intake, such as nightly fasting duration and meal frequency, and metabolic syndrome among Kuwaiti adults. A 24-hour recall was used to assess temporal habits of dietary intake. Meal frequency was defined as the number of daily eating episodes. The study included a total of 757 adults aged 20 years and older. The participants' mean age was 37.8 ± 12.3 …

The Impact Of A Living With Diabetes Experience On Students' Attitudes And Perceptions, Kristen Cook, Jessica Downes

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Optimizing Learning Experiences: The Integration Of Individualized Learning Agreements For Emergency Medicine Residents, Conor Dass, T.J. Welniak, Jason Langenfeld, Chad Branecki

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

An Inquiry Into The Relationship Between Practice Exam Integration, Study Habits, And Perceived Exam Confidence Among First-Year Medical Students At United States Medical School, Currey M. Zalman, G. Talmon, Kari Nelson

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Structured Laparoscopic Training And Its Impact On Enhancing Ambidexterity In Novice Medical Students, Lina Adwer, Kelsey Tieken, Irene Suh, Ka-Chun Siu

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Implementing A High-Fidelity Transgender Patient Simulation In Undergraduate Nursing, Kacee Child, Jenniepearl Spencer, Beth Culross

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Building Interprofessional Cultural Competency: Using Simulation And Improvisation To Address Intergenerational Issues In Asian American Pacific Islander (Aapi) Families, Priscila Rodrigues Armijo

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

A Novel Study To Assess Diagnostic Medical Sonography Students Belongingness In The Clinical Learning Environment, Kim Michael

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Impact Of Observed Structured Teaching Exercises (Oste) On Teaching Skills And Behavioral Change In A Clinician Educator Track Program, Priscila Rodrigues Armijo, Joe Pachunka, Sarah Kriss, Cory Rohlfsen

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Effect Of Increased Midlevel Provider Led Education In The Picu, Kayla Heidbrink, Lindsay Blick

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Education And Simulation Outcomes Of Death And Dying Perceptions Of Rt Students, Cheryl Skinner, Lauren Driscoll

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Interprofessional Team Performance In Pediatric Settings: Analyzing Reflections From Qi-Trained Medical Students, Catherine Napolitano, Russell J. Buzalko, Gary L. Beck Dallaghan, Kari Simonsen

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Using Evidence-Based Practices To Improve Sonography Scan Lab Instruction: Peyton’S 4-Step Approach, Kathryn Wampler, Kim Michael

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Learner Influence On Pediatric Patient Experience: Exploring Family Members’ Perspectives, Catherine Napolitano, Kari Simonsen, Gary L. Beck Dallaghan, Russell J. Buzalko

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2024.

Telehealth Evaluation In The United States: Protocol For A Scoping Review, Yunxi Zhang, Yueh-Yun Lin, Lincy S Lal, Jennifer C Reneker, Elizabeth G Hinton, Saurabh Chandra, J Michael Swint

Faculty, Staff and Student Publications

BACKGROUND: The rapid expansion of telehealth services, driven by the COVID-19 pandemic, necessitates systematic evaluation to guarantee the quality, effectiveness, and cost-effectiveness of telehealth services and programs in the United States. While numerous evaluation frameworks have emerged, crafted by various stakeholders, their comprehensiveness is limited, and the overall state of telehealth evaluation remains unclear.

OBJECTIVE: The overarching goal of this scoping review is to create a comprehensive overview of telehealth evaluation, incorporating perspectives from multiple stakeholder categories. Specifically, we aim to (1) map the existing landscape of telehealth evaluation, (2) identify key concepts for evaluation, (3) synthesize existing evaluation frameworks, …

Sans-Cnn: An Automated Machine Learning Technique For Spaceflight Associated Neuro-Ocular Syndrome With Astronaut Imaging Data, Sharif Amit Kamran, Khondker Fariha Hossain, Joshua Ong, Nasif Zaman, Ethan Waisberg, Phani Paladugu, Andrew G Lee, Alireza Tavakkoli

Faculty, Staff and Student Publications

Spaceflight associated neuro-ocular syndrome (SANS) is one of the largest physiologic barriers to spaceflight and requires evaluation and mitigation for future planetary missions. As the spaceflight environment is a clinically limited environment, the purpose of this research is to provide automated, early detection and prognosis of SANS with a machine learning model trained and validated on astronaut SANS optical coherence tomography (OCT) images. In this study, we present a lightweight convolutional neural network (CNN) incorporating an EfficientNet encoder for detecting SANS from OCT images titled "SANS-CNN." We used 6303 OCT B-scan images for training/validation (80%/20% split) and 945 for testing …

Gpr56 In Gvl: Marker Or Mechanism?, Audra N Iness, Pavan Bachireddy

Faculty, Staff and Student Publications

No abstract provided.

Embracing Cancer Complexity: Hallmarks Of Systemic Disease, Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James Degregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A Febbraio, Andrés Hidalgo, Mariam Jamal-Hanjani, Johanna A Joyce, Matthew Kaiser, Katja Lamia, Jason W Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan J Patel, Sergio Quezada, Jennifer A Wargo, Ashani Weeraratna, Eileen White, Frank Winkler, John N Wood, Karen H Vousden, Douglas Hanahan

Faculty, Staff and Student Publications

The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism …