Medicine and Health Sciences Commons^™

The Role Of Computational Methods In Cardiovascular Medicine: A Narrative Review, Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Gerard E Francisco, Franco Molteni, Jörg Wissel, Andrea Santamato

Faculty, Staff and Student Publications

Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. A search was conducted in the Web of Science database for articles focused on the use of BoNT-A in spasticity published between 2000 and 2022. We extracted various metrics, including counts of publications and contributions from different countries, institutions, authors, and journals. Analytical methods in CiteSpace were employed for the examination of co-citations, collaborations, and the co-occurrence …

Chromatin Profiles Are Prognostic Of Clinical Response To Bortezomib-Containing Chemotherapy In Pediatric Acute Myeloid Leukemia: Results From The Cog Aaml1031 Trial, Anneke D Van Dijk, Fieke W Hoff, Yihua Qiu, Stefan E Hubner, Robin L Go, Vivian R Ruvolo, Amanda R Leonti, Robert B Gerbing, Alan S Gamis, Richard Aplenc, Edward A Kolb, Todd A Alonzo, Soheil Meshinchi, Eveline S J M De Bont, Terzah M Horton, Steven M Kornblau

Faculty, Staff and Student Publications

The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children's Oncology Group phase 3 trial AAML1031 (NCT01371981). Proteasome inhibition influences the chromatin landscape and proteostasis, and we hypothesized that baseline proteomic analysis of histone- and chromatin-modifying enzymes (HMEs) would identify AML subgroups that benefitted from bortezomib addition. A proteomic profile of 483 patients treated with AAML1031 chemotherapy was generated using a reverse-phase protein array. A relatively high expression of 16 HME was associated with lower EFS and …

Building Equitable Mental Health Care For Latino Children: Perspectives From Providers And Communities, Francisco Banda, Greeshma James, Karina Vasudeva, Michelle Franklin, Andrea Thoumi, Rushina Cholera

Psychological Science Faculty Publications

Background: The current pediatric mental health crisis has disproportionately impacted Latino youth in the United States (US), as demonstrated by their elevated risks of depression, substance use disorder, and anxiety. Despite this, research suggests Latino youth receive inequitable mental health services.

Objective: To understand best practices, challenges, and priorities in providing accessible and equitable mental health care for Latino youth from the perspectives of front-line mental health providers and Latino community members.

Methods: A bicultural, bilingual researcher conducted semi-structured interviews with 20 participants with expertise in Latino mental health. Topics included barriers and facilitators to mental health care access and …

Transcription Factor C/Ebpα Is Required For The Development Of Ly6chi Monocytes But Not Ly6clo Monocytes, Sunkyung Kim, Jing Chen, Feiya Ou, Tian-Tian Liu, Suin Jo, William E Gillanders, Theresa L Murphy, Kenneth M Murphy

2020-Current year OA Pubs

Monocytes comprise two major subsets, Ly6C

Constant-Ph Simulations With The Polarizable Atomic Multipole Amoeba Force Field, Andrew C Thiel, Matthew J Speranza, Sanika Jadhav, Lewis L Stevens, Daniel K Unruh, Pengyu Ren, Jay W Ponder, Jana Shen, Michael J Schnieders

2020-Current year OA Pubs

Accurately predicting protein behavior across diverse pH environments remains a significant challenge in biomolecular simulations. Existing constant-pH molecular dynamics (CpHMD) algorithms are limited to fixed-charge force fields, hindering their application to biomolecular systems described by permanent atomic multipoles or induced dipoles. This work overcomes these limitations by introducing the first polarizable CpHMD algorithm in the context of the Atomic Multipole Optimized Energetics for Biomolecular Applications (AMOEBA) force field. Additionally, our implementation in the open-source Force Field X (FFX) software has the unique ability to handle titration state changes for crystalline systems including flexible support for all 230 space groups. The …

Funcpep V20: An Updated Database Of Functional Short Peptides Translated From Non-Coding Rnas, Swati Mohapatra, Anik Banerjee, Paola Rausseo, Mihnea P Dragomir, Ganiraju C Manyam, Bradley M Broom, George A Calin

Faculty, Staff and Student Publications

Over the past decade, there have been reports of short novel functional peptides (less than 100 aa in length) translated from so-called non-coding RNAs (ncRNAs) that have been characterized using mass spectrometry (MS) and large-scale proteomics studies. Therefore, understanding the bivalent functions of some ncRNAs as transcripts that encode both functional RNAs and short peptides, which we named ncPEPs, will deepen our understanding of biology and disease. In 2020, we published the first database of functional peptides translated from non-coding RNAs-FuncPEP. Herein, we have performed an update including the newly published ncPEPs from the last 3 years along with the …

Patient Characteristics Of, And Remedial Interventions For, Complaints And Medico-Legal Claims Against Doctors: A Rapid Review Of The Literature, Timothy J Schultz, Michael Zhou, Jodi Gray, Jackie Roseleur, Richard Clark, Dylan A Mordaunt, Peter D Hibbert, Georgie Haysom, Michael Wright

Faculty, Staff and Student Publications

BACKGROUND: It is uncertain if patient's characteristics are associated with complaints and claims against doctors. Additionally, evidence for the effectiveness of remedial interventions on rates of complaints and claims against doctors has not been synthesised.

METHODS: We conducted a rapid review of recent literature to answer: Question 1 "What are the common characteristics and circumstances of patients who are most likely to complain or bring a claim about the care they have received from a doctor?" and Question 2 "What initiatives or interventions have been shown to be effective at reducing complaints and claims about the care patients have received …

Cholesterol Levels As A Function Of Household Income, Kayla Adams, Noah Feldman, Kylie Mcmahon

School of Allied Health Professions Research Day

Introduction: Cholesterol levels are part of routine testing and can be indicators for cardiovascular disease. Due to low socioeconomic status, people's diets may differ and therefore increase cholesterol levels. This study was performed to assess socioeconomic status among, low, middle, and high household income.

Purpose: The purpose of this study was to identify the differences amongst cholesterol levels in low, middle, and high socioeconomic statuses.

Methods: Data sets from the 2017-2018 NHANES from the Centers of Disease Control and Prevention (CDC) were downloaded using SAS Universal Viewer and transferred to excel. The groups were then divided into low income (under …

Investigating The Relationship Between Vitamin D And Family Income, Kamara Allen, Caroline Pellorin, Kristyn Tallo

School of Allied Health Professions Research Day

Intro:

Vitamin D is a fat-soluble vitamin that aids in the absorption of both calcium and phosphorus that are important for bone development and integrity. Vitamin D may be obtained naturally through dietary intake and a chemical conversion when sunlight is absorbed through the skin. The association of family income may be attributed to Vitamin D levels because of a lack of beneficial resources.

Purpose:

Investigating the relationship between Vitamin D levels in the body and family income.

Methods:

Research conducted from NHANES 2017-2018 data, downloaded into SAS Universal Viewer, and organized into Excel. A one-way ANOVA and Tukey test …

Benefits Of A Community-Based Occupational Therapy Wellness Program For Unhoused Or Recently Housed Individuals, Peyton Babin, Bailey Hempfill, Megan Talamo, Sloane Tatarski

School of Allied Health Professions Research Day

Introduction. There have been no prior studies that have specifically researched the benefits of a community-based occupational therapy wellness program with the unhoused and recently housed population. We find it important to close the gap in research, as occupational therapists are well-equipped to work with the unhoused and recently housed population.

Purpose. To determine if there is a need for a community based occupational therapy

wellness program for unhoused and recently housed individuals.

Methods. Six participants who were unhoused or recently housed completed the Canadian

Occupational Performance Measure (COPM) and semi structured interviews. Interview

transcripts were reviewed separately using the …

A Qualitative Examination Of The Role Of Occupational Therapy In Addressing Health Disparities In Older Adults Through Community Programming At Fit Lot, Jessica Bigness, Gabrille Hodson, John Toups, John To

School of Allied Health Professions Research Day

Introduction: Underserved communities with limited access to resources such as quality health care, exercise programs, and outdoor community spaces face health disparities and lower life expectancy. Older adults make up a large portion of these vulnerable populations.

Purpose: We explored the benefits of an 8-week wellness program for older adults in the Greater New Orleans area. The program, which, consists of 60-minute classes one day a week, combines mental health wellness activities with aerobic and strength-based exercise, and is structured to take place at FitLot outdoor fitness parks.

Methods: We conducted semi-structured interviews with five community-based occupational therapists to determine …

Comparison Of Three Novel Strategies For Reducing Opioid Use After Orthopedic Surgery: A Systematic Review, Mallory Borel

School of Allied Health Professions Research Day

Background: Reducing opioid consumption remains a central topic amongst public health officials and healthcare providers. Research shows that orthopedic surgeons remain one of the top prescribers of opioids. The purpose of this study is to compare the efficacy of 3 strategies developed in the past 10 years that have shown potential to reduce opioid consumption in orthosurgery patients.

Methods: Online databases were used to identify published studies that focused on opioid reduction interventions among orthopedic surgery clinics. These interventions included opioid-free analgesia (OFA), strict opioid prescribing protocols (SOPP), and perioperative opioid education (POE). After review and exclusion, 32 studies were …

Functional Outcomes Following Aca Stroke: A Case Report, Dakota Brogdon

School of Allied Health Professions Research Day

Introduction: Anterior cerebral artery (ACA) infarcts are far less prevalent than other stroke presentations due to complex collateral blood supply in the region. Patients with a stroke affecting the ACA often have poorer outcomes due to frontal lobe involvement and a lack of evidence regarding therapeutic interventions in the acute phase.

Purpose: The purpose of this case report is to assess functional outcomes and meaningful changes in executive function in a 67-year-old male following ischemic ACA infarct.

Methods: Retrospective case study assessing functional outcomes following an inpatient rehabilitation stay. Interventions chosen on a priority basis: 1) does it facilitate education, …

The Relationship Between Hba1c Levels And Physical Activity: A One Way Anova, Monique Broussard, Palmer Lamartiniere, Cole Pitman

School of Allied Health Professions Research Day

Introduction:

HbA1C test is a diagnositic tool utilized by providers as a cornerstone in monitoring blood glucose in diabetics and a parameter in determing how well managed the condition is. Although there are many medicinal inteventions for diabetes, it is important to not neglect the positive effect lifestyle modifications such as physical activity may have on overall management. Physical activity is accepted as a tool in improving quality of life, decreasing BMI, and improving insulin sensitivty, so its incorporation in diabetes management may prove to be crucial.

Purpose:

To investigate the effect of physical activity on HbA1C levels in patients …

Inpatient Rehabilitation For A 63-Year Old Male Following A Pca Stroke: A Case Report, Zachary Dubois

School of Allied Health Professions Research Day

Intro

87% of all strokes are ischemic. The ischemic penumbra is a large research focus, but physical rehabilitation of a stroke research is scarce and focuses on MCA strokes. Knowledge of neural anatomy are key elements to rehabilitation, but limited research is available specifically on PCA strokes underscoring the need for tailored rehabilitation, as illustrated in this case study.

Purpose

This case delves into the complexities of inpatient rehabilitation for a PCA stroke patient, highlighting challenges like insufficient family support, socioeconomic struggles, alcoholism, and coordination deficits. Through this analysis, the study aims to offer insights into tailored interventions addressing the …

Total Knee Arthroplasty Rehabilitation: Case Report, Peyton Haynes

School of Allied Health Professions Research Day

Background: Chronic pain is one of the leading causes of disability in the United States that affects daily

life. Osteoarthritis is the most common form of arthritis that affects over 32.5 million US adults. A total

knee arthroplasty (TKA) is the most performed surgery conducted on the lower extremity.

Purpose: The objective of this case report is to describe evidence-based practices regarding the

rehabilitation and interventions utilized to facilitate the return to functional independence of a 77-year-old

that underwent a total knee arthroplasty.

Methods: The patient in this case report is a 77-year-old female that presented to outpatient physical

therapy …

Vitamin D Levels As A Function Of Women Of Reproductive Age, Ansam Isaid, Jasmine Weber, Whitney Smith

School of Allied Health Professions Research Day

Intro: Vitamin D is a steroid prohormone that is synthesized in the skin under ultraviolet sun exposure. It is an essential vitamin that is necessary for bone and teeth health, immune function, brain health, and for regulating inflammation. Evidence shows that increases in Vitamin D positively affect women of childbearing age. Low vitamin D status is associated with impaired fertility, endometriosis, PCOS, and an increased risk of development of osteoporosis.

Purpose: The purpose of our study is to investigate the effects of Vitamin D levels on women of childbearing ages

Methods(s): Research was conducted using the datasets found from the …

The Extent Of Varying Daily Alcohol Consumption On C-Rp Levels As A Marker Of Inflammation, Marley Katz, Kentra Bellard, Jordan Blake

School of Allied Health Professions Research Day

Introduction:

Inflammation is the body’s intrinsic response to injury or infection. C-reactive protein (CRP) levels are a commonly used marker of inflammation. Alcohol is a known inflammatory agent therefore we would expect chronic alcohol use to cause an elevation in CRP. The independent variable is the average number of alcoholic beverages ingested in the past 12 months. The dependent variable is serum CRP levels.

Purpose:

The purpose of this study was to investigate the differences in CRP levels in relation to the number of alcoholic beverages consumed per day.

Method:

Data sets were used from the National Health and Nutrition …

Improving Functional Mobility In Stage Iv Glioblastoma: A Case Report, Victoria Lacour

School of Allied Health Professions Research Day

Introduction: Glioblastoma is a highly aggressive form of primary brain tumor, presenting significant challenges in treatment and rehabilitation due to its infiltrative nature and poor prognosis. Despite advancements in cancer care, effective rehabilitation strategies for glioblastoma patients remain limited.

Purpose: This study aims to explore a physical therapy rehabilitation approach for improving functional mobility in patients with stage IV glioblastoma. Through a detailed case report, the challenges faced by these patients, the interventions employed, and the outcomes achieved are explored.

Methods: A 58-year-old female with stage IV glioblastoma underwent rehabilitation following a revision right temporal craniotomy for tumor resection and …

The Relationship Between Highest Level Of Education And Systolic Blood Pressure, Colin Lovecchio, Olivia Charouleau, Michael Hogan

School of Allied Health Professions Research Day

Introduction

Sze Yan Liu, et.al. (2016) demonstrated a clear relationship between blood pressure readings and education level.

Purpose

The purpose of this present investigation was to build upon the findings of Sze Yan Liu, et.al (2016) and further explore the relationship between educational status and its effect on systolic blood pressure.

Method

Data sets from the Centers of Disease Control and Prevention (CDC; 2017-2018)) were downloaded using SAS Universal Viewer. The data sets were then transferred to Excel 2016 for merging, sorting, and statistical analysis.

Subjects were divided into 3 groups based on their highest education level. A one-way ANOVA …

Cholesterol Levels As A Function Of Marital Status, Molly Mchale, Kayley Terminie, Samantha Evans

School of Allied Health Professions Research Day

Introduction: According to the CDC, cardiovascular disease is the leading of death in the United States. In an article by Jung et al., totat serum cholesterol is thought to be one of the main causes of coronary atherosclerosis and increased risk of cardiovascular disease.

Purpose: The purpose of this study is to investigate the relationship between total cholesterol levels and cardiovascular health between 3 groups: married, divorced, and single.

Methods: Secondary data sets from the Centers of Disease Control and Prevention (CDC; 2014) were utilized for the study. SAS Universal Viewer was used to download the data sets and then …

Management And Rehabilitation Of Cervical Myelopathy Post Acdf, Najah Mousa

School of Allied Health Professions Research Day

Introduction:

This case report highlights the pivotal role of physical therapy (PT) in managing and rehabilitating a 60-year-old male diagnosed with cervical myelopathy. Severe spinal stenosis, particularly at C3-C4, warranted PT intervention before and after anterior cervical fusion surgery (ACDF). The patient's initial presentation featured impaired sensation, muscle weakness, and balance issues translating to overall impaired functional mobility.

Purpose:

To emphasize the crucial involvement of PT in the acute care and recovery of a patient with cervical myelopathy, detailing the tailored plan of care and interventions.

Methods:

PT diagnoses identified deficits in functional mobility, activity tolerance, weakness, and impaired sensation. …

Acute Care Physical Therapy Intervention For Acute Respiratory Distress Syndrome (Ards) In The Presence Of Weight Bearing Restrictions, Karli Sassone

School of Allied Health Professions Research Day

INTRODUCTION

In the acute care setting, physical therapy (PT) interventions aim to prepare patients for discharge. This case study follows a patient that suffered pelvic/ sacral fractures and a pneumothorax due to a motor vehicle accident (MVA), further complicated by respiratory infection, ultimately culminating in ARDS. PT interventions are paramount to the recovery of ARDS survivors, and must address resulting functional limitations and mobility impairments post-mechanical ventilation and sedation.

PURPOSE

This case report outlines the role of PT intervention in a patient that suffered several complications from a MVA. The purpose of this report was to document the patient’s progression …

Benign Paroxysmal Positional Vertigo (Bppv) Following Concussion In A 73-Year-Old Female: A Case Report, Kaitlyn Scheurich

School of Allied Health Professions Research Day

Introduction

Benign Paroxysmal Positional Vertigo (BPPV) is the most common vestibular disorder, characterized by brief attacks of rotary vertigo triggered by changes in head position relative to gravity. The most prevalent type of BPPV is associated with the posterior semicircular canal within the vestibular system. Posterior semicircular canal BPPV can be diagnosed and treated by physical therapists who have increased knowledge and skill concerning the vestibular system.

Purpose

The purpose of this case report is to describe physical therapy examination and management using vestibular rehabilitation of a 73-year old female with posterior canal BPPV after concussion and previously failed vestibular …

Experiences Of First-Generation Students In Pt Education: A Qualitative Analysis, Kolby Sculthorp, Joseph Reese, Justin Gulizo, Zachary Ingram, Emily Ransom, Olivia Bernstein

School of Allied Health Professions Research Day

Introduction: While diversity in the United States population continues to grow, many health care professions do not reflect this increasing diversity. One minority group that has historically been underrepresented in health care includes first-generation (FG) students. Current research illustrates the experiences of FG students earning degrees in health care professions; however, there is little knowledge on FG students pursuing a Doctor of Physical Therapy degree (DPT).

Purpose. This study's purpose was to explore the experiences of current FG students and how these experiences impact their pursuit of a physical therapy career.

Methods. Using a qualitative research design, semi-structured interview questions …

Rehabilitation Strategies And Outcomes In Pectoralis Major Tendon Rupture: A Case Study, Pooja Shah

School of Allied Health Professions Research Day

Introduction

Pectoralis major tendon ruptures are rare injuries due to excessive tension on a maximally eccentrically contracted muscle. This case reports aims to depict the timeliness of diagnosis and treatment for pectoralis major injuries and the efficacy of surgical repair combined with rehabilitation in achieving optimal patient outcomes.

Purpose

The purpose of this case report is to highlight how factors such as tissue healing and the potential impact of psychological factors may have contributed to the rehabilitation of a grade III pectoralis major tendon rupture.

Case Description

The patient was an 18-year-old football player who suffered a grade III right …

Comprehensive Physical Therapy And Interdisciplinary Care For Impairments And Limitations Subsequent To Below-Knee Amputation: A Case Study, Trae Simoneaux

School of Allied Health Professions Research Day

Introduction: This case report explores the multifaceted challenges of comorbidities, contractures, pain, and discomfort in a below-knee amputee, emphasizing the vital role of comprehensive care and multidisciplinary approaches.

Purpose: Addressing the complexities encountered by below-knee amputees, this report underscores the importance of comprehensive care and multidisciplinary approaches in managing these challenges effectively.

Methods: The case of a 69-year-old African American female with diabetes-related below-knee amputation is detailed, including her physical therapy and hospitalizations. A thorough examination informed the development of a comprehensive plan of care.

Results: The examination identified impairments, limitations, and participation restrictions linked to the amputation and comorbidities. …

Biopsychosocial Treatments For The Management Of Dyspareunia And Sexual Dysfunction In Women: A Systematic Review, Mikayla Sonneborne, Laurie J. Gundlach, Claire E. Herwehe

School of Allied Health Professions Research Day

Background: Dyspareunia is pain experienced before, during, or after sexual intercourse and has a biopsychosocial etiology. This condition can lead to anxiety and depression in patients and its complex etiology requires a multimodal approach to treatment.

Purpose: This review aimed to determine the efficacy of treating dyspareunia with multimodal approaches targeting both mind and body treatment strategies.

Methods: A systematic literature search was conducted in PubMed, Cinahl, Embase, ProQuest, and Pedro for articles published from January 2003 to August 2023. Eight studies met inclusion and exclusion criteria. Three randomized controlled trials and 5 prospective cohort studies were included. Data was …

Fun With Food: A Cooking Intervention For Adults With Intellectual And Developmental Disabilities, Sadie Spring, Emma Hurley, Rachel Pham, Olivia Ruch, Rebecca Wannamaker

School of Allied Health Professions Research Day

INTRODUCTION. Occupational therapy (OT) strives to improve people's well-being and involvement in daily life by encouraging their participation in meaningful activities. Persons with IDD face barriers to participation in meaningful occupations which limit their functional independence. Current studies reveal that there is a need for individuals with IDD to have access to participation in nutrition education and food skills programs to increase their autonomy.

PURPOSE. We examined the efficacy of the Fun with Food protocol as an effective, evidence-based intervention to improve knowledge of nutrition and performance in grocery shopping, money management, and meal preparation in adults with intellectual and …

Conservative Management Of Anterior Hip Pain With Suspected Acetabular Labral Tear In A D1 Collegiate Volleyball Player: A Case Report, Elise St Pe

School of Allied Health Professions Research Day

Background

Acetabular labral injuries are relatively common injuries in young athletes that lead to pain and disability, and cause many athletes to miss playing time in their sport. Labral injuries are typically treated surgically, however this leads to more time missed due to the lengthy recovery process. Currently, there is limited research on the conservative management of anterior hip pain due to labral pathology due to the majority of athletes receiving surgical intervention.

Purpose

The purpose of this case report is to describe the effectiveness of non-operative, sport specific physical therapy interventions in treating a collegiate volleyball player with anterior …