Medicine and Health Sciences Commons^™

Disparities In Access To A Regular Primary Care Physician Among First-Generation Migrants With Early Psychosis In Ontario, Canada., Crystal Valdez, Rebecca Rodrigues, Jennifer Reid, Kelly K Anderson

Department of Medicine Publications

Disparities in primary care utilization among migrants with early psychosis may be related to lack of access to a regular primary care physician. This study aimed to investigate access to a regular primary care physician among first-generation migrants with early psychosis. People aged 14-35 years with first onset non-affective psychotic disorder in Ontario, Canada were identified in health administrative data (N = 39,440). Access to a regular primary care physician through enrollment in the year prior to diagnosis was compared between first-generation migrants (categorized by country of birth) and the general population using modified Poisson regression. Most migrant groups had …

Utilizing Aromatherapy To Decrease Anxiety In Adults Experiencing Homelessness, Thomas A. Clawson

Theses and Graduate Projects

This scholarly project analyzes health disparities faced by people experiencing homelessness, specifically in regard to their mental health and how they experience heightened levels of anxiety when compared to individuals who have stable housing. Through a literature review, the use of Lavender (Lavandula angustifolia) was analyzed and has shown to be an effective non-pharmacologic treatment for anxiety in a multitude of settings. Utilizing a theoretical framework distilled from Margret Newman’s theory Health as Expanding Consciousness, and Martha Rogers’ The Science of Unitary Human Beings. The quality improvement project was implemented at an inner city resource center for people experiencing homelessness. …

Implementation Of Vinyasa Yoga For Adults Experiencing Anxiety, Megan K. Malyuk

Theses and Graduate Projects

Anxiety disorders are the most prevalent mental illness in the United States (US) and holistic treatment approaches, such as vinyasa yoga, are often practiced to alleviate the severity of symptoms (The Anxiety and Depression Association of America, 2020). A comprehensive literature review including evidence-based research, Metis-based knowledge, and personal accounts are used to support this scholarly project. Jean Watson’s Theory of Human Caring is explicated and synthesized as a theoretical framework. Methodology and evaluation of the scholarly project are described, analyzed, and reflected that vinyasa yoga has a positive impact on individuals who experience anxiety. This scholarly project was implemented …

Screening Environmental Soil Samples For Antibiotic Production, Paige Mattick

SACAD: Scholarly Activities

Antibiotic resistance is a detrimental worldwide challenge, producing bacterial infections that are progressively more difficult to treat and cure. To attempt to help alleviate this issue, we screened soil samples for the presence of antibiotic-producing microorganisms. Soil samples were collected and diluted to 1:100 and 1:1000 ratios of soil and distilled water. These soil mixtures were then streaked onto tryptic soy agar (TSA) plates and incubated at 30℃ until colonies developed. These colonies were then selected and plated on a lawn of Serratia marcescens, which was utilized as the target organism.

Serratia marcescens was selected due to its known resistance …

The Role Of School-Based Dental Sealing Programs And Fluoride Varnish In Preventing Caries, Gyuri Park

SACAD: Scholarly Activities

To examine the effectiveness of school-based dental sealant programs and fluoride varnish applied to the teeth, we analyzed existing research on both methods. We also reviewed data from past research to reason the need for state funds, a sealant metric, and the elimination of prior exam rules for hygienists to increase dental sealant programs in the United States. Both dental sealants and fluoride varnish applied to the molar were found to be effective in caries prevention in existing dental research.

Apigenin Alleviates Autistic-Like Stereotyped Repetitive Behaviors And Mitigates Brain Oxidative Stress In Mice, Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sadek

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed in its pharmacological action as a positive allosteric modulator of α7-nAChRs. However, there is no research describing the pharmacological potential of APG in ASD. The aim of this study was to evaluate the effects of the subchronic systemic treatment of APG (10–30 mg/kg) on ASD-like repetitive and compulsive-like behaviors and oxidative stress status in the hippocampus and cerebellum in BTBR mice, utilizing the reference drug aripiprazole (ARP, 1 …

Nationwide Survey: Disparities In Speech-Language Pathology Service Knowledge Between Hispanic Communities And The General Public Through Explanatory Mixed Methods, Kendra Lujan, Katie Geerdes, Madalyn Morelock, Ran An

SACAD: Scholarly Activities

Despite ongoing efforts to bridge healthcare disparities, ethnic and language minorities continue to face significant challenges in accessing services (Mahmoud et al., 2014). Yet, in the realm of speech-language pathology (SLP) services, scant empirical research has identified the barriers impeding minority clients' access (Mahendra et al., 2009). With the Hispanic population growing (United States Census Bureau, 2023), identifying their knowledge of and potential access to speech-language pathology services is crucial. This study employed mixed explanatory methods, conducted a nationwide survey with 227 participants across 27 states, and interviewed 12 participants from both Hispanic and non-Hispanic communities, elucidating the challenges faced …

Assessing Language Abilities In School-Age Children With Autism Spectrum Disorder: Practices Of Speech-Language Pathologists, Mckayla M. Sprague, Cassandra Callahan, Tyrell Perrigo, Ran An

SACAD: Scholarly Activities

Through an online survey conducted with 64 certified speech-language pathologists (SLPs) from 23 U.S. states, this study sheds light on the complex process of assessing language skills in school-aged children with Autism Spectrum Disorder (ASD). The responses gathered reveal the significant challenges SLPs face, stemming from the vast diversity within the ASD spectrum. These insights strongly suggest a need for adopting assessment strategies that are not only more adaptable and thorough, but also deeply mindful of neurodiversity and the distinct communication skills present in children with ASD.

Trends In Medicare Utilization And Reimbursement For Hematology/Oncology Procedures From 2012 To 2023: A Geriatric Oncology Perspective, Julijana Conic, Thomas Reske

School of Medicine Faculty Publications

Objectives: Given the scarcity of data exploring reimbursement trends in the field of hematology/oncology, we sought to characterize these trends for common procedures in this field from 2012 to 2023. Methods: Using the Centers for Medicare and Medicaid Services' Physician Fee Schedule Look-Up Tool we collected reimbursement data for 40 hematology/oncology procedure codes from 2012 to 2023. Data was adjusted to 2023 United States (US) dollars using the Consumer Price Index (CPI). Results: From 2012 to 2023 gross reimbursement for the facility price decreased 4.4% and increased 9.2% for the non-facility price. When adjusted for inflation, compensation decreased 96.1% and …

Implementing Continuous Glucose Monitoring: A Quality Improvement Project, Molly Suydam

DNP Projects

Significance and Background: Continuous glucose monitoring (CGM) devices are beneficial for assessing blood glucose measurements throughout the day by simply waving a smartphone over the sensor that’s attached to the back of a patient’s arm. Patients with T2DM who check blood glucose measurements via finger-sticks, have to undergo numerous daily finger-sticks. Over time, this action can grow very cumbersome while CGM offers real-time blood glucose measurements without having to pierce the skin repeatedly. CGM use in patients with T2DM may help to improve overall blood glucose measurements.

Purpose: To trial CGM in patients with T2DM and monitor blood glucose measurements …

Naloxone Prescribing For High-Risk Opioid Patients In Primary Care, Theresa Turk

SACAD: Scholarly Activities

Objective: Primary care providers have an integral role in combating the opioid epidemic and preventing opioid-related deaths. One method of prevention is prescribing naloxone to patients at high risk for overdose. Naloxone is a medication that bystanders may administer during an overdose situation that can reverse the life-threatening side effects of opioids. The purpose of this quality improvement project was to increase the number of naloxone prescriptions written by primary care providers to patients on opioids considered at high risk for overdose. High-risk patients were considered those prescribed opioids over 50 morphine equivalents (MME) and those who had co-prescribed benzodiazepines. …

Effects Of Yoga On Older Residing In Assisted Living Facilities, Anita Walters, Luke Kriley

SACAD: Scholarly Activities

Although the number of adults aged 65 and older has been steadily increasing world-wide for the past three decades, few studies have been conducted to explore the benefits of a yoga-type exercise program for those residing in assisted living facilities. A within-subjects repeated measures quasi-experimental design was used to examine the effectiveness of standing yoga postures in improving strength, balance, and quality of life in older adults currently residing in an assisted living facility. In the single-group design the participants were pre-assessed in week one, reassessed in week 2 for test-retest reliability, attended a 30-minute exercise session three times per …

"The Relevant History And Medical And Ethical Future Viability Of Xenotransplantation", Morgan Janes

Augustana Center for the Study of Ethics Essay Contest

Xenotransplantation, the transplantation of organs or tissues from one species to another, presents a complex nexus of medical, ethical, and cultural considerations. In this article, we delve into the multifaceted landscape of xenotransplantation, beginning with a thorough examination of its relevant historical trajectory. From early experiments to recent advancements, we chart the evolution of this field, setting the stage for a nuanced discussion. We then confront the central issue: the true medical viability of xenotransplantation and the looming specter of operative risk. By scrutinizing the ethical dilemmas inherent in xenotransplantation through a multicultural lens, we illuminate the diverse perspectives that …

Nursing The Wright Way: A History Of Nursing At Wright State University, 1973-2023, Donna Miles Curry

Books Authored by Wright State Faculty/Staff

This book explores the history of an innovative nursing education program in Dayton, Ohio from its creation in the 1970s until 2023. On the cutting edge with a theory driven curriculum this program went from BSN, adding the master's degree with advanced practice options and also a DNP.

Perspectives On The Implementation Of Health Informatics Curricula Frameworks, Zerina Lokmic-Tomkins, Kalpana Raghunathan, Helen Almond, Richard G. Booth, Susan Mcbride, Mari Tietze, Michelle Honey, Paula Procter, Monica Peddle, Lisa Mckenna

Nursing Faculty Publications and Presentations

Background: The COVID-19 pandemic highlighted the necessity of equipping health professionals with knowledge and skills to effectively use digital technology for healthcare delivery. However, questions persist about the best approach to effectively educate future health professionals for this. A workshop at the 15th Nursing Informatics International Congress explored this issue.

Objective: To report findings from an international participatory workshop exploring pre-registration informatics implementation experiences. Methods: A virtual workshop was held using whole and small group interactive methods aiming to 1) showcase international examples of incorporating health informatics into pre-registration education; 2) highlight essential elements and considerations for integrating health informatics …

Implementing Occupational Therapy Principles Into The Linden Waldorf Neurodivergent Student Population, Brooke M. Bledsoe

OTD Capstone Projects

This doctoral capstone project was completed through partnership with Linden Waldorf School in Nashville, TN. The focus of this project was development, implementation, and advocacy regarding occupational therapy techniques for the neurodivergent student population. The goal of this project was to provide direct observations, educational presentations, and various educational materials on a variety of neurodivergent deficits and diagnoses in order to help empower Linden Waldorf faculty and staff to best meet the needs of their students. The deficits and diagnoses covered in this project are as follows: executive dysfunction, emotional dysregulation, dyslexia, autism spectrum disorder, anxiety, and attention deficit hyperactivity …

Best Practice For Creating A Sensory Garden And Calming Cart For Preschool-Aged Children At A Reggio-Inspired Preschool, Emmalee Lawrence

OTD Capstone Projects

The goal of this capstone project was to create program plans for a sensory garden and calming cart as well as create resources for parents and teachers on the use and benefit of these plans for the children at First Presbyterian Church Early Preschool. Research on current programs at the preschool indicated the school could benefit from additional sensory and calming opportunities. The programs created during this capstone project were meant to improve sensory exploration, increase overall emotional well-being, as well as support developmental milestones in preschool-aged children. The goals of this project were achieved through collaboration with staff, teachers, …

Post-Modeling Adjustments And Delivered Dose Verification Of The 6fff Beam Model Commissioned For The Monaco Treatment Planning System, Grant C. Debevec

LSU Master's Theses

External beam radiation therapy has been shown to be an effective treatment method for tumors and abnormalities of the spine and vertebral region. Treating the spine using a stereotactic body radiation therapy (SBRT) technique can reduce toxicity to the spinal cord. The 6 MV flattening filter free (6FFF) beam model is currently used to plan and calculate dose for SBRT treatment plans, and the treatment plans are delivered using a linear accelerator (LINAC).

The commissioned beam model represents an invariant component of a LINAC. For volumetric modulated arc therapy (VMAT) treatment plans, the multileaf collimator (MLC) positions are changing throughout …

The Investigation Of Collaboration Among First-Year Bachelor Of Science Nursing Students, Christie Marie Cavallo

Walden Dissertations and Doctoral Studies

Despite the benefits of collaboration, first-year nursing students prefer not to work together. It was important to find out why nursing students do not want to collaborate. The purpose of this study was to discover first-year nursing students’ and faculty’s perceptions of how instructor-created opportunities for collaboration contributed to first-year nursing students’ collaboration. Using Wenger’s communities of practice (CoPs) model as a lens, the data were explored using a qualitative explanatory case study approach. This study consisted of individual interviews of 12 first-year nursing students and nursing faculty. Inclusion criteria included students enrolled in or faculty teaching first year of …

Funcpep V20: An Updated Database Of Functional Short Peptides Translated From Non-Coding Rnas, Swati Mohapatra, Anik Banerjee, Paola Rausseo, Mihnea P Dragomir, Ganiraju C Manyam, Bradley M Broom, George A Calin

Faculty, Staff and Student Publications

Over the past decade, there have been reports of short novel functional peptides (less than 100 aa in length) translated from so-called non-coding RNAs (ncRNAs) that have been characterized using mass spectrometry (MS) and large-scale proteomics studies. Therefore, understanding the bivalent functions of some ncRNAs as transcripts that encode both functional RNAs and short peptides, which we named ncPEPs, will deepen our understanding of biology and disease. In 2020, we published the first database of functional peptides translated from non-coding RNAs-FuncPEP. Herein, we have performed an update including the newly published ncPEPs from the last 3 years along with the …

Nanocavity-Mediated Purcell Enhancement Of Er In Tio2 Thin Films Grown Via Atomic Layer Deposition, Cheng Ji, Michael T Solomon, Gregory D Grant, Koichi Tanaka, Muchuan Hua, Jianguo Wen, Sagar Kumar Seth, Connor P Horn, Ignas Masiulionis, Manish Kumar Singh, Sean E Sullivan, F Joseph Heremans, David D Awschalom, Supratik Guha, Alan M Dibos

Faculty, Staff and Student Publications

The use of trivalent erbium (Er3+), typically embedded as an atomic defect in the solid-state, has widespread adoption as a dopant in telecommunication devices and shows promise as a spin-based quantum memory for quantum communication. In particular, its natural telecom C-band optical transition and spin-photon interface make it an ideal candidate for integration into existing optical fiber networks without the need for quantum frequency conversion. However, successful scaling requires a host material with few intrinsic nuclear spins, compatibility with semiconductor foundry processes, and straightforward integration with silicon photonics. Here, we present Er-doped titanium dioxide (TiO2) thin film growth on silicon …

Biocomposite Anchors Have Greater Yield Load And Energy Compared With All-Suture Anchors In An In Vitro Ovine Infraspinatus Tendon Repair Model, Robert A. Walton, Lindsey Liuzza, Catherine Takawira, Claudia Leonardi, Mandi J. Lopez

School of Public Health Faculty Publications

Purpose: To compare tensile fatigue and strength measures of biocomposite and all-suture anchors in an ovine humerus-infraspinatus tendon model of rotator cuff repair. Methods: Infraspinatus tendons on adult ovine humeri were sharply transected at the insertion. One of each pair was assigned randomly for fixation with 2 biocomposite or all-suture anchors. Constructs were tested with 200 cycles of 20 to 70 N tensile load, and gap formation was measured at the incised tendon end every 50 cycles. They were subsequently tested to failure. Outcome measures including fatigue stiffness, hysteresis, creep, and gap formation and tensile stiffness, and yield and failure …

Cardiovascular Disease Management With Sodium-Glucose Cotransporter-2 Inhibitors In Patients With Type 2 Diabetes: A Cardiology Primer, Allan Zhang, Ramsey Kalil, Alexander Marzec, Stephanie A Coulter, Salim Virani, Kershaw V Patel, Matthew W Segar

Faculty, Staff and Students Publications

Patients with type 2 diabetes face an elevated risk of cardiovascular disease. This review centers on sodium-glucose cotransporter-2 (SGLT2) inhibitors, a class of drugs that, according to a growing body of evidence, may have major potential for managing cardiovascular disease in patients with type 2 diabetes. This review presents findings from multiple clinical trials suggesting that SGLT2 inhibitors can not only serve as preventive therapeutic agents but also play a role in the active management of heart failure. The discussion includes the mechanism of action of SGLT2 inhibitors, emphasizing that they enhance urinary glucose excretion, which could lead to improved …

Understanding Nurses' Experience Of The Covid-19 Pandemic Through The Lens Of Trauma, Grace Simmons

Walden Dissertations and Doctoral Studies

The destructive effects of the trauma experienced by nurses during the COVID-19 pandemic left nurses with long-term psychological and physical effects that impaired their ability to effectively care for their patients, their families, and themselves. Although researchers have described the nurses’ experiences using generalized psychological and physiological trauma-related symptomatology, none have grounded their studies within the context of trauma theory. The purpose of this qualitative descriptive study was to explore the lived experience of nurses caring for critically ill COVID-19 patients during the pandemic through the lens of trauma theory. The constructivist self-development theory (CSDT) provided the framework for understanding …

Dynamic Sars-Cov-2 Surveillance Model Combining Seroprevalence And Wastewater Concentrations For Post-Vaccine Disease Burden Estimates., Rochelle H. Holm, Grzegorz A. Rempala, Boseung Choi, J. Michael Brick, Alok R. Amraotkar, Rachel J. Keith, Eric C. Rouchka, Julia H. Chariker, Kenneth E. Palmer, Ted Smith, Aruni Bhatnagar

Faculty and Staff Scholarship

Background

Despite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates.

Methods

We used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021–August 2021 in Jefferson County, Kentucky (USA). Our susceptible (S" role="presentation" style="box-sizing: inherit; display: inline-block; line-height: normal; font-size-adjust: none; word-spacing: normal; overflow-wrap: normal; text-wrap-mode: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; …

The Effect Of Skin Tone Inclusive Dermatology Education On Diagnostic Accuracy And Self-Confidence In Graduate Nursing Students, Kaylyn Bourne, Laura Gray

DNP Projects

Abstract

BACKGROUND: People with skin of color face worse health outcomes than their light-skinned peers. According to the literature, graduate nursing programs lack skin tone inclusive curricular content (Shue-McGuffin & Powers, 2022). This contributes to disproportionate racial and ethnic health disparities. Skin tone inclusive online dermatology modules have been shown to improve diagnostic accuracy and self-confidence among medical students and residents in primary care specialties (Trinh et al., 2021; Salava & Salmela, 2022; Wang et al., 2020). Similar models may be an effective approach for graduate nursing students as they prepare to evaluate skin disease across the skin tone …

Altered Platelet-Megakaryocyte Endocytosis And Trafficking Of Albumin And Fibrinogen In Runx1 Haplodeficiency, Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Liying Guan, Mohammad Afaque Alam, Kiwon Lee, Mortimer Poncz, A. Koneti Rao

Cardeza Foundation for Hematologic Research

Platelet α-granules have numerous proteins, some synthesized by megakaryocytes (MK) and others not synthesized but incorporated by endocytosis, an incompletely understood process in platelets/MK. Germ line RUNX1 haplodeficiency, referred to as familial platelet defect with predisposition to myeloid malignancies (FPDMMs), is associated with thrombocytopenia, platelet dysfunction, and granule deficiencies. In previous studies, we found that platelet albumin, fibrinogen, and immunoglobulin G (IgG) were decreased in a patient with FPDMM. We now show that platelet endocytosis of fluorescent-labeled albumin, fibrinogen, and IgG is decreased in the patient and his daughter with FPDMM. In megakaryocytic human erythroleukemia (HEL) cells, small interfering RNA …

Chromatin Profiles Are Prognostic Of Clinical Response To Bortezomib-Containing Chemotherapy In Pediatric Acute Myeloid Leukemia: Results From The Cog Aaml1031 Trial., Anneke D. Van Dijk, Fieke W. Hoff, Yihua Qiu, Stefan E. Hubner, Robin L. Go, Vivian R. Ruvolo, Amanda R. Leonti, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S J M De Bont, Terzah M. Horton, Steven M. Kornblau

Manuscripts, Articles, Book Chapters and Other Papers

The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children's Oncology Group phase 3 trial AAML1031 (NCT01371981). Proteasome inhibition influences the chromatin landscape and proteostasis, and we hypothesized that baseline proteomic analysis of histone- and chromatin-modifying enzymes (HMEs) would identify AML subgroups that benefitted from bortezomib addition. A proteomic profile of 483 patients treated with AAML1031 chemotherapy was generated using a reverse-phase protein array. A relatively high expression of 16 HME was associated with lower EFS and higher 3-year …

Essential Right Heart Physiology For The Perioperative Practitioner Poqi Ix: Current Perspectives On The Right Heart In The Perioperative Period, Matthew D Mcevoy, Paul M Heerdt, Vicki Morton, Raquel R Bartz, Timothy E Miller, Poqi Ix Collaborators

Faculty, Staff and Students Publications

As patients continue to live longer from diseases that predispose them to right ventricular (RV) dysfunction or failure, many more patients will require surgery for acute or chronic health issues. Because RV dysfunction results in significant perioperative morbidity if not adequately assessed or managed, understanding appropriate assessment and treatments is important in preventing subsequent morbidity and mortality in the perioperative period. In light of the epidemiology of right heart disease, a working knowledge of right heart anatomy and physiology and an understanding of the implications of right-sided heart function for perioperative care are essential for perioperative practitioners. However, a significant …

Wnk Kinase Is A Vasoactive Chloride Sensor In Endothelial Cells, Tessa A C Garrud, Briar Bell, Alejandro Mata-Daboin, Dieniffer Peixoto-Neves, Daniel M Collier, Julio F Cordero-Morales, Jonathan H Jaggar

Faculty, Staff and Student Publications

Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl-) is the most abundant anion in ECs and the Cl- sensitive With-No-Lysine (WNK) kinase is expressed in this cell type. Whether intracellular Cl- signaling and WNK kinase regulate EC function to alter arterial contractility is unclear. Here, we tested the hypothesis that intracellular Cl- signaling in ECs regulates arterial contractility and examined the signaling mechanisms involved, including the participation of WNK kinase. Our data obtained using two-photon microscopy and cell-specific inducible knockout mice indicated that acetylcholine, …