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Articles 54781 - 54810 of 329124
Full-Text Articles in Medicine and Health Sciences
Initiating Access To Palliative Care Earlier In Pediatric Oncology Patients, Anita Sharma
Initiating Access To Palliative Care Earlier In Pediatric Oncology Patients, Anita Sharma
Doctor of Nursing Practice Final Manuscripts
Abstract
Background: Pediatric oncology patients should be referred to palliative care early but despite research indicating the clear benefits, there is still a delay in referring patients. One of the reasons include lack of understanding amongst providers on what palliative care is. Palliative care provides symptom management, emotional support and helps the patient and family with difficult decision making.
Objectives: This project aimed to increase the number of early referrals to palliative care. The Pediatric Palliative Care Screening Tool (PaPas) was utilized to help identify the triggers which should prompt the referral.
Methods: A chart review of patients diagnosed with …
The Effect Of A Lactobacillus Containing Gel On The Clitoral Microbiome Of The Mare, Fiona E. Herzog
The Effect Of A Lactobacillus Containing Gel On The Clitoral Microbiome Of The Mare, Fiona E. Herzog
LSU Master's Theses
The equine lower reproductive tract harbors bacterial populations that serve as a reservoir for potential pathogens. Dysbiosis of urogenital sites may play a role in reproductive disease of the mare, including endometritis. Metagenetic studies have evaluated microbiomes in the uterus, vagina and placenta, while the clitoral microbiome has yet to be described. In this study, the following hypotheses were tested; 1) the clitoris harbors a unique microbiome, 2) topical Lactobacillus genus complex (LGC) probiotic will alter this microbiome, 3) acceptable per cycle pregnancy rates (PCPR) following probiotic application will be achieved. Reproductively normal mares (n=14) were selected, and clitoral fossa …
Librarian Support For Graduate Medical Education: 5-Year Check-In, Abby L. Adamczyk, Mlis, Ahip, Gary Kaplan, Mslis, Ahip, John Caruso, Md
Librarian Support For Graduate Medical Education: 5-Year Check-In, Abby L. Adamczyk, Mlis, Ahip, Gary Kaplan, Mslis, Ahip, John Caruso, Md
Academic Commons and Scott Memorial Library Staff Papers and Presentations
Background
The SKMC Office of the Dean through its Graduate Medical Education (GME) Section identified a need for more comprehensive support for GME research efforts. This was intensified as the residency program requirements began to formalize the expectations and quantification of scholarly output for both trainees and core GME faculty.1 In consultation with the Director of the Academic Commons, this GME-focused position was conceptualized to better meet the needs of our residents and faculty, and thus enhance the scholarly projects of our GME constituency. This would build on existing scholarly support2 including professional writing services.3 As part of the Information …
Restrictive Covenants In Surgical Care: Time To Reconsider, Andrew J. Malek, Ian L. Mcculloch, Alan Z. Yang, Goutam K. Gadiraju, Justin M. Broyles
Restrictive Covenants In Surgical Care: Time To Reconsider, Andrew J. Malek, Ian L. Mcculloch, Alan Z. Yang, Goutam K. Gadiraju, Justin M. Broyles
School of Medicine Faculty Publications
No abstract provided.
Lay Advisor Interventions For Hypertension Outcomes: A Systematic Review, Meta-Analysis And A Re-Aim Evaluation, Sonal J. Patil, Leila Bushweller, Eno-Obong Udoh, Irina Todorov, Robert Saper, Kurt C. Stange, Shari Bolen
Lay Advisor Interventions For Hypertension Outcomes: A Systematic Review, Meta-Analysis And A Re-Aim Evaluation, Sonal J. Patil, Leila Bushweller, Eno-Obong Udoh, Irina Todorov, Robert Saper, Kurt C. Stange, Shari Bolen
Faculty Scholarship
Introduction: Lay advisor interventions improve hypertension outcomes; however, the added benefits and relevant factors for their widespread implementation into health systems are unknown. We performed a systematic review to: (1) summarize the benefits of adding lay advisors to interventions on hypertension outcomes, and (2) summarize factors associated with successful implementation in health systems using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework. Methods: We systematically searched several databases, including Ovid MEDLINE, CINAHL, PsycINFO from January 1981 to May 2023. All study designs of interventions delivered solely by lay advisors for adults with hypertension were eligible. If both arms received the …
05.20.2024 Orsp Connect, Liz Williamson
05.20.2024 Orsp Connect, Liz Williamson
ORED Newsletter
NIH RPPR Update (Research Performance Progress Report)
Assessing Associations Between Individual-Level Social Determinants Of Health And Covid-19 Hospitalizations: Investigating Racial/Ethnic Disparities Among People Living With Human Immunodeficiency Virus (Hiv) In The U.S. National Covid Cohort Collaborativ, Dimple Vaidya, Kenneth J. Wilkins, Eric Hurwitz, Jessica Y. Islam, Dongmei Li, Jing Sun, Sandra E. Safo, Jennifer M. Ross, Cara D. Varley, Multiple Additional Authors
Assessing Associations Between Individual-Level Social Determinants Of Health And Covid-19 Hospitalizations: Investigating Racial/Ethnic Disparities Among People Living With Human Immunodeficiency Virus (Hiv) In The U.S. National Covid Cohort Collaborativ, Dimple Vaidya, Kenneth J. Wilkins, Eric Hurwitz, Jessica Y. Islam, Dongmei Li, Jing Sun, Sandra E. Safo, Jennifer M. Ross, Cara D. Varley, Multiple Additional Authors
OHSU-PSU School of Public Health Faculty Publications and Presentations
Abstract Background: Leveraging the National COVID-19 Cohort Collaborative (N3C), a nationally sampled electronic health records repository, we explored associations between individual-level social determinants of health (SDoH) and COVID-19-related hospitalizations among racialized minority people with human immunodeficiency virus (HIV) (PWH), who have been historically adversely affected by SDoH. Methods: We retrospectively studied PWH and people without HIV (PWoH) using N3C data from January 2020 to November 2023. We evaluated SDoH variables across three domains in the Healthy People 2030 framework: (1) healthcare access, (2) economic stability, and (3) social cohesion with our primary outcome, COVID-19-related hospitalization. We conducted hierarchically nested additive …
Proteomic Characterization And Cytotoxic Potential Of Proteins From Cuscuta (Cuscuta Epithymum (L.) Crude Herbal Product Against Mcf-7 Human Breast Cancer Cell Line, Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed
Proteomic Characterization And Cytotoxic Potential Of Proteins From Cuscuta (Cuscuta Epithymum (L.) Crude Herbal Product Against Mcf-7 Human Breast Cancer Cell Line, Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed
Pharmacy Faculty Articles and Research
Background
The burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta, used in traditional medicine for different ailments, including cancer, is known for containing phytochemicals that exhibit anticancer activity; however, the bioactivities of proteins from this plant remain unexplored. This study aimed to screen the cytotoxic potential of proteins from the crude herbal product of Cuscuta epithymum(L.) (CE) harvested from the host plants Alhagi maurorum and Medicago sativa.
Methods
The proteins from CE were extracted using a salting-out method, followed by fractionation with a gel filtration chromatography column. Gel-free shotgun …
Efficacy Of Empirical Ciprofloxacin Or Cefixime Plus Metronidazole Therapy For The Treatment Of Liver Abscess: A Randomized Control Clinical Trial, Navneet Sharma, Vishal Sharma, Nipun Verma, Sreedhara Bettadahally Chaluvashetty, Ajay Prakash, Harsimran Kaur
Efficacy Of Empirical Ciprofloxacin Or Cefixime Plus Metronidazole Therapy For The Treatment Of Liver Abscess: A Randomized Control Clinical Trial, Navneet Sharma, Vishal Sharma, Nipun Verma, Sreedhara Bettadahally Chaluvashetty, Ajay Prakash, Harsimran Kaur
Faculty, Staff and Students Publications
Liver abscess is a potentially life-threatening medical emergency. Prompt empirical antimicrobial with or without percutaneous aspiration or drainage is therapeutic. The rational for using empirical intravenous broad-spectrum antimicrobials upfront instead of oral Fluoroquinolone or Cephalosporin is contentious. In this double blind randomized control clinical trial 69 participants received Ciprofloxacin (500 mg q 12 hourly) and 71 participants received Cefixime (200 mg q 12 hourly) orally for 2 weeks. Both the group received oral Metronidazole (800 mg q 8 hourly) for 2 weeks and percutaneous drainage or aspiration of the abscess was done as per indication and followed-up for 8 weeks. …
Generalizing Parkinson’S Disease Detection Using Keystroke Dynamics: A Self-Supervised Approach, Luca Giancardo
Generalizing Parkinson’S Disease Detection Using Keystroke Dynamics: A Self-Supervised Approach, Luca Giancardo
Faculty, Staff and Student Publications
Objective: Passive monitoring of touchscreen interactions generates keystroke dynamic signals that can be used to detect and track neurological conditions such as Parkinson's disease (PD) and psychomotor impairment with minimal burden on the user. However, this typically requires datasets with clinically confirmed labels collected in standardized environments, which is challenging, especially for a large subject pool. This study validates the efficacy of a self-supervised learning method in reducing the reliance on labels and evaluates its generalizability.
Materials and methods: We propose a new type of self-supervised loss combining Barlow Twins loss, which attempts to create similar feature representations with reduced …
Il-2-Free Tumor-Infiltrating Lymphocyte Therapy With Pd-1 Blockade Demonstrates Potent Efficacy In Advanced Gynecologic Cancer, Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Weihui Shi, Yao Ge, Chunhong Liu, Zhen Lu, Robert C Bast, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li, Rong Chen, Shupeng Liu, Huajun Jin, Binghui Zhao, Zhongping Cheng
Il-2-Free Tumor-Infiltrating Lymphocyte Therapy With Pd-1 Blockade Demonstrates Potent Efficacy In Advanced Gynecologic Cancer, Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Weihui Shi, Yao Ge, Chunhong Liu, Zhen Lu, Robert C Bast, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li, Rong Chen, Shupeng Liu, Huajun Jin, Binghui Zhao, Zhongping Cheng
Faculty, Staff and Student Publications
BACKGROUND: Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinical and clinical studies to evaluate the safety, antitumor activity, and pharmacokinetics of an innovative modified regimen in patients with advanced gynecologic cancer.
METHODS: Patient-derived xenografts (PDX) were established from a local recurrent cervical cancer patient. TILs were expanded ex vivo from minced tumors without feeder cells in the modified TIL therapy regimen. Patients underwent low-dose cyclophosphamide lymphodepletion followed by TIL infusion without intravenous IL-2. The primary endpoint was safety; the secondary endpoints included objective response rate, …
Systemic Inflammatory Markers Of Persistent Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage
Systemic Inflammatory Markers Of Persistent Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage
Faculty, Staff and Student Publications
In the first part of this article, the role of intestinal epithelial tight junctions (TJs), together with gastrointestinal dopaminergic and renin-angiotensin systems, are narratively reviewed to provide sufficient background. In the second part, the current experimental data on the interplay between gastrointestinal (GI) dopaminergic and renin-angiotensin systems in the regulation of intestinal epithelial permeability are reviewed in a systematic manner using the PRISMA methodology. Experimental data confirmed the copresence of DOPA decarboxylase (DDC) and angiotensin converting enzyme 2 (ACE2) in human and rodent enterocytes. The intestinal barrier structure and integrity can be altered by angiotensin (1-7) and dopamine (DA). Both …
Developing A Membrane-Proximal Cd33-Targeting Car T Cell, Ruby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Jasmine S Um, Winson Cai, Sarah Yoo, Andrew Dunbar, Young Park, Devin Mcavoy, Kinga K Hosszu, Ross L Levine, Jaap Jan Boelens, Ivo C Lorenz, Renier J Brentjens, Anthony F Daniyan
Developing A Membrane-Proximal Cd33-Targeting Car T Cell, Ruby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Jasmine S Um, Winson Cai, Sarah Yoo, Andrew Dunbar, Young Park, Devin Mcavoy, Kinga K Hosszu, Ross L Levine, Jaap Jan Boelens, Ivo C Lorenz, Renier J Brentjens, Anthony F Daniyan
Faculty, Staff and Student Publications
BACKGROUND: CD33 is a tractable target in acute myeloid leukemia (AML) for chimeric antigen receptor (CAR) T cell therapy, but clinical success is lacking.
METHODS: We developed 3P14HLh28Z, a novel CD33-directed CD28/CD3Z-based CAR T cell derived from a high-affinity binder obtained through membrane-proximal fragment immunization in humanized mice.
RESULTS: We found that immunization exclusively with the membrane-proximal domain of CD33 is necessary for identification of membrane-proximal binders in humanized mice. Compared with clinically validated lintuzumab-based CAR T cells targeting distal CD33 epitopes, 3P14HLh28Z showed enhanced in vitro functionality as well as superior tumor control and increased overall survival in both …
Reaction Mechanisms Of H2s Oxidation By Naphthoquinones, Zhilin Ma, Katherine Wilson, Zachary Joseph, Ian Kyle, Stephen M Kasko, Prentiss Jones, Jon Fukuto, Ming Xian, Gang Wu, Karl D Straub
Reaction Mechanisms Of H2s Oxidation By Naphthoquinones, Zhilin Ma, Katherine Wilson, Zachary Joseph, Ian Kyle, Stephen M Kasko, Prentiss Jones, Jon Fukuto, Ming Xian, Gang Wu, Karl D Straub
Faculty, Staff and Student Publications
1,4-naphthoquinones (NQs) catalytically oxidize H2S to per- and polysufides and sulfoxides, reduce oxygen to superoxide and hydrogen peroxide, and can form NQ-SH adducts through Michael addition. Here, we measured oxygen consumption and used sulfur-specific fluorophores, liquid chromatography tandem mass spectrometry (LC-MS/MS), and UV-Vis spectrometry to examine H2S oxidation by NQs with various substituent groups. In general, the order of H2S oxidization was DCNQ ~ juglone > 1,4-NQ > plumbagin >DMNQ ~ 2-MNQ > menadione, although this order varied somewhat depending on the experimental conditions. DMNQ does not form adducts with GSH or cysteine (Cys), yet it readily oxidizes H2S to polysulfides and sulfoxides. …
Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph
Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph
Faculty Publications
Toxoplasma gondii is a parasitic infection that can be transmitted in utero, resulting in fetal chorioretinitis and other long-term neurological outcomes. If diagnosed early, pregnancy-safe chemotherapeutics can prevent vertical transmission. Unfortunately, diagnosis of acute, primary infection among pregnant women remains neglected, particularly in low-and-middle-income countries. Clinically actionable diagnosis is complex due to the commonality of infection during childhood and early adulthood which spawn long-last antibody titers and historically unreliable direct molecular diagnostics. The current study employed a cross-sectional T. gondii perinatal surveillance study using digital PCR, a next generation molecular diagnostic platform, and a maternal-fetal outcomes survey to ascertain …
Gilteritinib As Post-Transplant Maintenance For Aml With Internal Tandem Duplication Mutation Of Flt3, Mark J Levis, Geoffrey L Uy, Et Al.
Gilteritinib As Post-Transplant Maintenance For Aml With Internal Tandem Duplication Mutation Of Flt3, Mark J Levis, Geoffrey L Uy, Et Al.
2020-Current year OA Pubs
PURPOSE: Allogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of
METHODS: Adults with
RESULTS: Three hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided
CONCLUSION: Although the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable
Animals In Prison: Is There Value In Inmate-Animal Rehabilitation Programs?, I. H. C.
Animals In Prison: Is There Value In Inmate-Animal Rehabilitation Programs?, I. H. C.
Tredway Library Prize for First-Year Research
This paper demonstrates the benefits of animal rehabilitation programs in alleviating the mental harm of incarceration and improving outcomes for individuals upon their release. I.H.C. details the overwhelming mental health crises and conditions that inmates face in prison, arguing to redefine rehabilitation to center both practical preparations and on healing the underlying traumas and mental health concerns before release. His numerous examples drawn from prisons around the world thoroughly uphold the evidence that animal rehabilitation programs improve inmate wellbeing, decrease violent incidents in prison, enhance vocational and employment opportunities post-incarceration, and overall change inmates’ behavior – all benefits that ultimately …
Empowering Personalized Pharmacogenomics With Generative Ai Solutions, Christie M Ballantyne, Katherine M Robinson, James C Coons, Liwen Wang, Philip E Empey, Richard A Gibbs
Empowering Personalized Pharmacogenomics With Generative Ai Solutions, Christie M Ballantyne, Katherine M Robinson, James C Coons, Liwen Wang, Philip E Empey, Richard A Gibbs
Faculty, Staff and Students Publications
Objective: This study evaluates an AI assistant developed using OpenAI's GPT-4 for interpreting pharmacogenomic (PGx) testing results, aiming to improve decision-making and knowledge sharing in clinical genetics and to enhance patient care with equitable access.
Materials and methods: The AI assistant employs retrieval-augmented generation (RAG), which combines retrieval and generative techniques, by harnessing a knowledge base (KB) that comprises data from the Clinical Pharmacogenetics Implementation Consortium (CPIC). It uses context-aware GPT-4 to generate tailored responses to user queries from this KB, further refined through prompt engineering and guardrails.
Results: Evaluated against a specialized PGx question catalog, the AI assistant showed …
A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko
A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko
Karbala International Journal of Modern Science
Infectious myonecrosis virus (IMNV) disease causes mass mortality and decreased shrimp production. The RdRp region projects to the interior, where it may function in transcription. The focus of this study was to determine the effect of amino acid polymorphisms from several countries on the structure of RdRp and identify the potential of watercress in inhibiting IMNV by targeting the RdRp protein of IMNV through an in silico approach. The results showed that the structure of the IMNV RdRp protein from Indonesia was similar to Mexico, and the protein structure from India_QDN was identical to India_QIL. Ligand binding affinity values showed …
Deconstructing Drugs: Addressing The Stigma, Harm Reduction, And Policy Solutions, Charlotte Theriault
Deconstructing Drugs: Addressing The Stigma, Harm Reduction, And Policy Solutions, Charlotte Theriault
Themis: Research Journal of Justice Studies and Forensic Science
Black and homeless people who struggle with substance use disorder (SUD), especially opioid use disorder (OUD), have experienced unique obstacles due to inequalities relating to their social determinants of health (SDOH). Historical context and peer-reviewed research were used to evaluate racial bias and expand upon the factors that contributed to the opioid crisis, the effects of COVID-19 on drug overdoses, and the presence of fentanyl in illicit drug supplies. Various studies combat the stigma surrounding substance use disorder (SUD) by acknowledging the disease as a chronic health condition. Research showed that the most effective way to combat these inequalities and …
Global Age-Sex-Specific Mortality, Life Expectancy, And Population Estimates In 204 Countries And Territories And 811 Subnational Locations, 1950–2021, And The Impact Of The Covid-19 Pandemic: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2021, Austin E. Schumacher, Hmwe Hmwe Kyu, Catherine M. Antony, Aleksandr Y. Aravkin, Gulrez Shah Azhar, Catherine Bisignano, Katrin Burkart, Kelly M. Cercy, Eunice Chung, Kaleb Coberly, Haley Comfort, Ewerton Cousin, Garland T. Culbreth, Matthew Cunningham, Nicole Davis Weaver, Louisa Degenhardt, Lee Deitesfeld, M. Ashworth Dirac, Kara Estep, Valery L. Feigin, Abraham D. Flaxman, Luisa S. Flor, Lisa M. Force, John E. Fuller, Veincent Christian Pepito
Global Age-Sex-Specific Mortality, Life Expectancy, And Population Estimates In 204 Countries And Territories And 811 Subnational Locations, 1950–2021, And The Impact Of The Covid-19 Pandemic: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2021, Austin E. Schumacher, Hmwe Hmwe Kyu, Catherine M. Antony, Aleksandr Y. Aravkin, Gulrez Shah Azhar, Catherine Bisignano, Katrin Burkart, Kelly M. Cercy, Eunice Chung, Kaleb Coberly, Haley Comfort, Ewerton Cousin, Garland T. Culbreth, Matthew Cunningham, Nicole Davis Weaver, Louisa Degenhardt, Lee Deitesfeld, M. Ashworth Dirac, Kara Estep, Valery L. Feigin, Abraham D. Flaxman, Luisa S. Flor, Lisa M. Force, John E. Fuller, Veincent Christian Pepito
Ateneo School of Medicine and Public Health Publications
Background
Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.
Methods
22 223 data sources …
Social Needs Screening And Intervention In Pediatric Primary Care: Impact On Families’ Experience Of Care, Sarah D. Ronis, Marie Masotya, Kurt C. Stange
Social Needs Screening And Intervention In Pediatric Primary Care: Impact On Families’ Experience Of Care, Sarah D. Ronis, Marie Masotya, Kurt C. Stange
Faculty Scholarship
Introduction/Objectives: Social determinants of health (SDoH) screening and intervention in pediatric primary care depends upon caregiver disclosure of adverse household or social conditions and thus may be influenced by perceived bias or stigma. This paper examines to what extent parents’ experience of their child’s medical home is associated with their perceptions of a practice-based social needs intervention. Methods: We conducted a cohort study of data reported by 73 parents of children obtaining care in a medical home with an embedded SDoH navigation program. Using survey data collected in October 2021 and October 2022, we calculated descriptive statistics and non-parametric bivariate …
Lyme Disease In The Northeast: The Unintended Consequence Of Suburban Development, Hayden Neubert
Lyme Disease In The Northeast: The Unintended Consequence Of Suburban Development, Hayden Neubert
Student Theses 2015-Present
This paper addresses the role of suburban development in the suburbs of the Northeastern United States in increasing human Lyme disease infection. Over the past 50 years, Lyme disease has become the most common vector-borne disease in the United States. In 2021, the two states with the most Lyme disease cases were New York and New Jersey, with a collective 6,524 cases, with Connecticut still representing 541 total cases. It is not a coincidence that case numbers are concentrated in suburban areas with high forest fragmentation. Chapter 1 of this essay analyzes how human land development disrupts bioregulatory ecosystem actors …
Burden Of Disease Scenarios For 204 Countries And Territories, 2022–2050: A Forecasting Analysis For The Global Burden Of Disease Study 2021, Stein Emil Vollset, Hazim S. Ababneh, Yohannes Habtegiorgis Abate, Cristiana Abbafati, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi, Mohammad Abdollahi, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Olumide Abiodun, Richard Gyan Aboagye, Hassan Abolhassani, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Abdorrahim Absalan, Veincent Christian Pepito
Burden Of Disease Scenarios For 204 Countries And Territories, 2022–2050: A Forecasting Analysis For The Global Burden Of Disease Study 2021, Stein Emil Vollset, Hazim S. Ababneh, Yohannes Habtegiorgis Abate, Cristiana Abbafati, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi, Mohammad Abdollahi, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Olumide Abiodun, Richard Gyan Aboagye, Hassan Abolhassani, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Abdorrahim Absalan, Veincent Christian Pepito
Ateneo School of Medicine and Public Health Publications
Background
Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050.
Methods
Using forecasts of major drivers of health such as the Socio-demographic …
Global Fertility In 204 Countries And Territories, 1950–2021, With Forecasts To 2100: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2021, Natalia V. Bhattacharjee, Austin E. Schumacher, Amirali Aali, Yohannes Habtegiorgis Abate, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Samar Abd Elhafeez, Sherief Abd-Elsalam, Mohammad Abdollahi, Mohammad Amin Abdollahifar, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Samrawit Shawel Abebe, Olumide Abiodun, Hassan Abolhassani, Meysam Abolmaali, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Woldu Aberhe Abrha, Michael R.M. Abrigo, Veincent Christian Pepito
Global Fertility In 204 Countries And Territories, 1950–2021, With Forecasts To 2100: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2021, Natalia V. Bhattacharjee, Austin E. Schumacher, Amirali Aali, Yohannes Habtegiorgis Abate, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Samar Abd Elhafeez, Sherief Abd-Elsalam, Mohammad Abdollahi, Mohammad Amin Abdollahifar, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Samrawit Shawel Abebe, Olumide Abiodun, Hassan Abolhassani, Meysam Abolmaali, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Woldu Aberhe Abrha, Michael R.M. Abrigo, Veincent Christian Pepito
Ateneo School of Medicine and Public Health Publications
Background
Accurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 …
Exploring Attachment Through Clay-Based Therapy: A Parent-Child Community Engagement Project, Hilari Stahler
Exploring Attachment Through Clay-Based Therapy: A Parent-Child Community Engagement Project, Hilari Stahler
Expressive Therapies Capstone Theses
This research project explores the therapeutic potential of clay, particularly as a creative, sensory-rich process that facilitates access to pre-verbal memories. Grounded in attachment theory and the innovative approach to trauma healing by Cornelia Elbrecht, known as Trauma Healing at the Clay Field®, the study investigates clay's regressive and healing qualities. It examines how its smooth, skin-like texture can activate our implicit memories through sensory experiences. Utilizing a community engagement format, this study aimed to assess the effectiveness of parent-child clay field sessions in addressing intergenerational attachment trauma and unmet attachment needs. The research revealed that the unique properties of …
Design, Synthesis, And Biological Evaluation Of Novel Heterocyclic Compounds For The Treatment Of Cancer And Neurodegenerative Disorders, Saloni Patel
Electronic Theses and Dissertations
Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment, mostly in older people. It is the leading cause of dementia in late adult life. The hallmarks of AD include neuronal loss, neuroinflammation, a build-up of extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles, and extracellular neuritic plaques. Current treatment, although useful, is not adequate. Identification of therapeutic agents with the potential to alter the progress of AD is a high priority. Recent studies suggest that the Sigma-2 receptor is an attractive target for the development of disease-modifying AD drugs. Preventing the binding of Sigma-2 receptors …
Artistic Expression Of Medical Experiences Of Mothers Of Color: Perspectives Using Art Therapy, Lauren Barrett
Artistic Expression Of Medical Experiences Of Mothers Of Color: Perspectives Using Art Therapy, Lauren Barrett
Expressive Therapies Dissertations
The purpose of this study was to qualitatively examine perspectives of mothers of color living in the US and their experiences in the healthcare system through art therapy. The study aimed to further identify personal narrative experiences of mothers of color navigating the healthcare system, promote individual voices, and acknowledge disparities impacting those within marginalized communities. The participants in this study included a total of eight identified mothers of color (non-White) living in the US. Participants took part in four weeks of consecutive art therapy sessions either in 60-minute group or individual virtual meetings. One art therapy directive was provided …
A Trauma-Informed Socially Just Approach To Working With Juvenile Justice-Involved Youth Utilizing Expressive Arts Therapy, Ciara Carr
Expressive Therapies Capstone Theses
Youth involved with the juvenile justice system often have a history of trauma and oppression resulting from their positionality and circumstances. Most juvenile justice-involved youth are boys, youth of color, low-income, LGBTQIA2S+, disabled, and traumatized. This literature review explores the history of the juvenile justice system, issues with the present-day model, and trauma-informed and transformative justice approaches to practice. The implementation of socially just, trauma-informed expressive arts therapy programs is proposed as a more equitable practice to replace commonly used punitive practices across the United States. More research is needed to understand the impact of such programs on this population …
Colorful Conversations: Enhancing Communication In Nonspeaking Toddlers Through Art Therapy, Joy Wu
Colorful Conversations: Enhancing Communication In Nonspeaking Toddlers Through Art Therapy, Joy Wu
Expressive Therapies Capstone Theses
The purpose of this study was to learn how art therapy helps non-speaking children ages two years old build up their communication with others. Although there are not many early publications on the benefit of art therapy to children ages two, the existing research suggests that art therapy can aid those children in speaking based on the experience of art making. During the art creation process, engaging with art materials and their potential power can enable the expression and conveyance of emotions as art serves as containment. Therefore, art therapy can assist nonspeaking toddlers to begin communicating verbally. This writer …