Medicine and Health Sciences Commons^™

Internship With Eppa, Masha Kasperovich, Joy Doan

Science Symposium

EPPA is an organization run by practicing physicians in emergency medicine. On staff with them, there are over 300 professional medical providers, including MD’s, DO’s, PA’s, and NP’s who staff the emergency rooms in partnered hospitals around Minnesota, specifically in the Twin Cities, St. Cloud, and rural Minnesota. Something that is special about EPPA is that the leadership and staff are all incredibly kind and have the desire to get to know you and help you along your journey. EPPA not only employs medical providers, but they also have a very special opportunity for college aged students in the pre-health …

Eppa Scribe Program, Renee Virtue, Sara Wyse

Science Symposium

Over the course of Fall semester, I started scribing with EPPA to gain experience working in the medical field with doctors and PAs. Working with a variety of different medical professionals allowed me to see the differences and similarities between working as a nurse, PA, or doctor. I learned how important it is to have an approachable bedside manner and to be willing to listen to your patients, time management, and balancing priorities of school and work. In addition, I got to witness a variety of medical procedures and developed a broader medical vocabulary. Overall, the internship helped deepen my …

Spectral Characterization Of High-Speed Sers Fluctuations, Makayla Schmidt, Emily A. Farley, Marit A. Engevik, Alexandre G. Brolo, Nathan Lemke, Nathan Lindquist

Science Symposium

The concept of plasmonic “hotspots” is central to the broad field of nanophotonics. In surface-enhanced Raman scattering (SERS), hotspots can increase Raman scattering efficiency by orders of magnitude. Hotspot dimensions may range from a few nanometers down to the atomic scale and are able to generate SERS signals from single molecules. However, these single-molecule SERS signals often show significant fluctuations, and the concept of intense, localized, yet static hotspots has come into question. Recent experiments have shown these SERS intensity fluctuations (SIFs) to occur over an extremely wide range of timescales, from seconds to micro-seconds, due to the various physical …

Sound Of The Mind: The Effects Of Music On Anxiety, Cassidy Yates, Joel Frederickson

Science Symposium

Anxiety is a growing condition around the world. People have a variety of solutions to mental illness. Maybe, our solution could be even more closely related to what we’re already doing. Bethel psychology students participated in this study, voluntarily, for credit in their psychology courses. 11 jazz listeners and 6 rock listeners had their heart rate monitored while listening to a song, all after participating in a state anxiety survey. The data reflect the heart rates before the song, 30 seconds into the song, 1 minute and 30 seconds into the song, at the end of 3 minutes and 1 …

Understanding The Relationship Between How The Availability Of Vaping Devices And Student Use Are Related: A Quantitative Study, Felicia L. Owen

ATU Theses and Dissertations 2021 - Present

The number of teens in Arkansas who are vaping continues to increase despite state and national laws and regulations. The availability of vaping devices to teens continues to occur; but limited research is available that explores if the availability is accessible through peers, families, or community members, or is self-sought. It is crucial to gain a better understanding of why vaping continues to increase among high school students in Arkansas. The purpose of this study is to understand the relationship between how the availability of vaping devices and student use are related. The analysis of exposure and student use varies …

The Impact Of Electronic Health Record Unintended Consequences On Quality Of Care Within A High Complexity Healthcare Organization, Joetta Powell

ATU Theses and Dissertations 2021 - Present

“Unintended consequences are unexpected, and unwanted outcomes that can limit the value of EHR implementation and adversely affect quality of care and patient safety” (Lee & Kang, 2021, p. 898). Few organizations have redesigned the EHR to improve usability to mitigate potential patient safety concerns. This study aims to identify unintended consequences in patient care workflows and determine educational needs related to EHR usability. A mixed method approach was used to investigate unintended consequences in deidentified patient safety reports submitted Jan 1, 2020, through December 31, 2023. The data was analyzed to identify error types and educational deficits. The Acute …

Unveiling The Nexus Of Cellular Quality Control: Exploring The Interplay Between Ribosome-Associated Protein Quality Control And Mitochondrial Quality Control Pathways, Foozhan Tahmasebinia

Biological Sciences Theses and Dissertations

In eukaryotic cells, the intricate interplay between cellular quality control mechanisms is crucial for maintaining homeostasis and safeguarding the integrity of vital processes, spanning from macromolecule synthesis to the renewal of entire cellular organelles.

Disruption of these networks can lead to severe diseases such as metabolic disorders, underscoring the interconnected nature and feedback control mechanisms inherent in biological systems, including cellular quality control systems. This interconnectedness extends to the intricate communication between organelles, enabling coordinated functioning and adaptation to changing cellular conditions, particularly in response to stressors.

While the exact mechanisms governing these communications within cellular quality control systems remain …

Utilizing Decision Tree Implementation And Provider Education To Improve Colorectal Cancer Screening Orders: A Quality Improvement Project, Alicia Kollar

Doctor of Nursing Practice (DNP) Manuscripts

Background and Significance: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths (Jain, et al., 2022). Healthy People 2030 objectives include reducing the CRC death rate and increasing the proportion of adults who get screened (Healthy People 2030, n.d.). According to 2021 data, only 58.7% of adults are screened with a Healthy People target of 68.3%. Healthy People states that there are effective screening tools to detect colorectal cancer early, and people are more likely to survive it (Healthy People 2030, n.d.). Purpose: This quality improvement (QI) project aims to implement an …

Strokes Of Excellence And Opportunity: A Program Evaluation Analyzing Emergency Department Stroke Care In A Newly Formed Five-Hospital Health System, Joshua Adams

Doctor of Nursing Practice (DNP) Manuscripts

Stroke is a significant public health problem in the United States and globally. For patients experiencing an acute ischemic stroke, also known as “infarct” or “brain attack,” the effectiveness of treatment is extremely time dependent. This DNP Project presents a program evaluation of stroke care delivered in five emergency departments (EDs) in community hospitals in a health system newly formed through the merger of two smaller organizations. This evaluation focused on assessing the five programs’ effectiveness in delivering timely and effective care to stroke patients with the standardized performance measure door-to-needle (DTN). The evaluation also included a review of factors …

Identify And Overcome The Barriers Of Care From A Patient And Provider Perspective In Adult Patients With Type 2 Diabetes Mellitus In A Federal Qualified Health Clinic: A Quality Improvement Project, Jill Miscovich

Doctor of Nursing Practice (DNP) Manuscripts

Diabetes is a significant healthcare issue that not only effects the United States but also has a global impact, it is costly for the workforce and to manage. Diabetes management is more complex in rural areas due to increased SDOH and barriers to care. The purpose of this quality improvement (QI) project is to identify and overcome the barriers to care from the patients and nurse practitioners’ (NPs) perspectives in adult patients with type 2 diabetes mellitus (T2DM) in a rural federal qualified health clinic (FQHC). A mixed method approach was used including qualitative and quantitative data project manager created …

Identify And Overcome The Barriers To Care From A Patient And Provider Perspective In Adult Patients With T2dm In A Rural Federal Qualified Health Clinic (Fqhc): A Quality Improvement (Qi) Project, Jill Miscovich

Doctor of Nursing Practice (DNP) Manuscripts

Diabetes is a significant healthcare issue that not only effects the United States but also has a global impact, it is costly for the workforce and to manage. Diabetes management is more complex in rural areas due to increased SDOH and barriers to care. The purpose of this quality improvement (QI) project is to identify and overcome the barriers to care from the patients and nurse practitioners’ (NPs) perspectives in adult patients with type 2 diabetes mellitus (T2DM) in a rural federal qualified health clinic (FQHC). A mixed method approach was used including qualitative and quantitative data project manager created …

Statistical Approaches For The Early Detection Of Colorectal Cancer Using Longitudinal Biomarkers, Emily Berry

Statistical Science Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States [45]. CRC is believed to advance from adenomatous polyps creating a unique opportunity for both early detection and cancer prevention [4, 23]. Like other diseases, CRC screening reduces mortality by detecting cancer at earlier, more treatable stages; however, it can also reduce incidence through the removal of precancerous lesions [4]. As a result, screening is recommended for average-risk adults ≥ 45 years of age and includes a variety of tests [4, 12]. Despite alternate screening options, colonoscopy capacity is often cited as a barrier to …

Barriers, Facilitators, And Competencies In Advocating For Adults With Intellectual Disabilities With Health Disparities, Carol Adams

Electronic Theses and Dissertations

Background: Nurses working in the specialty of intellectual disabilities are positioned to advocate for individuals with intellectual disabilities and other health disparities. This study explored nurses’ perceived competencies, barriers, and facilitators when advocating for improved health status in adult patients with intellectual disabilities.

Methods: Twenty-five nurses working in the specialty of intellectual disabilities were interviewed using semi-structured interviews, and the data were analyzed using thematic analysis.

Results: Barriers identified in advocacy were: Funding, Communication, Negative Perceptions and Misperceptions, Lack of access, and Diagnostic Overshadowing. Nurses were also facilitated in advocating for improved health status in people with intellectual disabilities. Facilitators …

School Nurses And Administrators Perceptions Of School Preparedness: A Focused Ethnography, Deborah Horton

Electronic Theses and Dissertations

Background: Disasters are dangerous for schools where many children are located in one area. Children were significantly impacted by a biological incident during the 2009 H1N1 influenza pandemic, and more recently the COVID-19 pandemic. Research is needed to determine the values, perceptions, and beliefs of school disaster preparedness through a cultural lens.

Methods: A focused ethnography was used to interview school administrators and nurses from April-December 2022 to explore and understand the unique culture of school disaster preparedness. Data was analyzed according to Leininger’s Four Phases of Data Analysis.

Results: Twenty-four participants from K-12 public schools were interviewed resulting in …

Impact Of An Electronic Human Papillomavirus Vaccination Catch-Up Module For Women With Criminal-Legal System Involvement, Shawana Moore

Electronic Theses and Dissertations

Introduction: Cervical cancer can often be prevented with targeted strategies such as Pap smear screenings and the human papillomavirus (HPV) vaccination, now also recommended for those aged 27-45 who have not received the vaccine previously. However, women involved in the criminal-legal system often miss out on primary and secondary prevention measures and are at increased risk for the development of cervical cancer caused by HPV. Purpose: The purpose of this study was to examine the feasibility and acceptability of an electronic HPV catch-up module for women in the criminal-legal system aged 27-45. The study, guided by the Health Belief Model, …

Defining Faculty’S Role In Supporting Student Mental Health Needs In Higher Education, Erica B. Riba

Student Theses

The subject of mental health among college students has been prevalent for decades. Today, college students are facing more challenges to mental wellness than ever before. Faculty are often the first and only point of contact for many students. Faculty have a role to play in supporting student mental health, but that role has not been clearly defined. This study aims to bring clarity to some of these critical issues and offers a lens into this broad topic from faculty themselves. A mixed-methods design was used for this study. 889 people who have downloaded The Jed Foundation’s Faculty Guide to …

The Lipid-Heart Hypothesis And The Keys Equation Defined The Dietary Guidelines But Ignored The Impact Of Trans-Fat And High Linoleic Acid Consumption, Mary T. Newport, Fabian M. Dayrit

Chemistry Faculty Publications

In response to a perceived epidemic of coronary heart disease, Ancel Keys introduced the lipid-heart hypothesis in 1953 which asserted that high intakes of total fat, saturated fat, and cholesterol lead to atherosclerosis and that consuming less fat and cholesterol, and replacing saturated fat with polyunsaturated fat, would reduce serum cholesterol and consequently the risk of heart disease. Keys proposed an equation that would predict the concentration of serum cholesterol (ΔChol.) from the consumption of saturated fat (ΔS), polyunsaturated fat (ΔP), and cholesterol (ΔZ): ΔChol. = 1.2(2ΔS - ΔP) + 1.5ΔZ. However, the Keys equation conflated natural saturated fat and …

Revisiting Snack-Time: Analyzing How A Food Prescription Program In Charleston, Ms Affects The Children Of Participating Parents And Caregivers, Aubrey Bethay

Honors Theses

This study examines how Food Rx programs impact the children of enrolled families. Currently, research in this area is limited to data that focuses on produce consumption rates and BMI; however, there are other measures of physical and mental well-being that require evaluation. Consequently, this paper takes a more comprehensive approach, looking into childrens’ sense of security and perception of healthy food. 10 parents (representing 23 children) were interviewed and participated in recorded focus groups in order to gather information. From here, their responses were organized into domains in order to categorize the data.

Many parents reported that their children …

Parental Factors Associated With Covid-19 Vaccine Uptake For Children Over 5 Years Of Age In Texas, Paula M Cuccaro, Jihye Choi, Yordanos M Tiruneh, Journey Martinez, Jing Xie, Michelle Crum, Mark Owens, Jose-Miguel Yamal

Faculty, Staff and Student Publications

The COVID-19 vaccine is safe and effective for children, yet parental hesitancy towards vaccinating children against the virus persists. We conducted a telephone-administered weighted survey in Texas to examine parents' sociodemographic factors and medical conditions associated with COVID-19 vaccination intention for parents with unvaccinated children ages 5-17 years. We collected responses from 19,502 participants, of which 4879 were parents of children ages 5-17 years. We conducted multiple logistic regression with Lasso-selected variables to identify factors associated with children's vaccination status and parents' intention to vaccinate their children. From the unweighted sample, less than half of the parents (46.8%) had at …

Charting The Covid Long Haul Experience - A Longitudinal Exploration Of Symptoms, Activity, And Clinical Adherence, Jessica Pater, Shaan Chopra, Jeanee Carroll, Juliette Zaccour, Fayika Farhat Nova, Tammy Toscos, Shion Guha Ms, Phd, Fenlei Chang Md, Phd

Health Services and Informatics Research

COVID Long Haul (CLH) is an emerging chronic illness with varied patient experiences. Our understanding of CLH is often limited to data from electronic health records (EHRs), such as diagnoses or problem lists, which do not capture the volatility and severity of symptoms or their impact. To better understand the unique presentation of CLH, we conducted a 3-month long cohort study with 14 CLH patients, collecting objective (EHR, daily Fitbit logs) and subjective (weekly surveys, interviews) data. Our findings reveal a complex presentation of symptoms, associated uncertainty, and the ensuing impact CLH has on patients’ personal and professional lives. We …

Improving Mental Health Support For Nursing Students Through Mental Health First Aid (Mhfa) Training Of Clinical Faculty, Amy Sands

Graduate Theses, Dissertations, and Capstones

This project aimed to implement a process improvement program at the Louisville campus of Galen College of Nursing to improve the mental health support for nursing students through the training of Clinical Instructors (CIs) in using adult Mental Health First Aid (MHFA) and the ALGEE actions described within that program.

Surgical Approach To Urethral Diverticulum And Urethrovaginal Fistula With Mesh Erosion, Alicia Smith, Lauren Burton, Saifuddin Mama

Einstein Health Papers

INTRODUCTION AND HYPOTHESIS: This video illustrates a rare surgical case involving a urethral diverticulum, urethrovaginal fistula, and mesh erosion.

METHODS: We present a 58-year-old patient attending a tertiary care center with a suspected urethrovaginal fistula. Her concerns included stress urinary incontinence (SUI), recurrent urinary tract infection, and vaginal pain. The surgical history was notable for the placement of two different mesh slings during the same procedure to treat SUI. Preoperative evaluation and findings are illustrated in detail. The video uses a high-definition surgical camera to emphasize the initial intraoperative evaluation with localization of the fistula and diverticulum. We then demonstrate …

Co-Designing Situated Displays For Family Co-Regulation With Adhd Children, Lucas M. Silva, Franceli L. Cibrian, Clarisse Bonang, Arpita Bhattacharya, Aehong Min, Elissa M. Monteiro, Jesus A. Beltran, Sabrina E. B. Schuck, Kimberley D. Lakes, Gillian R. Hayes, Daniel A. Epstein

Engineering Faculty Articles and Research

Family informatics often uses shared data dashboards to promote awareness of each other’s health-related behaviors. However, these interfaces often stop short of providing families with needed guidance around how to improve family functioning and health behaviors. We consider the needs of family co-regulation with ADHD children to understand how in-home displays can support family well-being. We conducted three co-design sessions with each of eight families with ADHD children who had used a smartwatch for self-tracking. Results indicate that situated displays could nudge families to jointly use their data for learning and skill-building. Accommodating individual needs and preferences when family members …

An Analysis Of Professional Education For Future Physicians To Address Implicit Racial Bias In Black Maternal Health, Jasmine Butler

Honors Theses

The history of medicine in the United States is littered with incidences of racism and exploitation of Black Americans. The extensive history of medical racism has continued to be perpetuated in healthcare today. Within the field of maternal health, the dark history of medicine shows its face with the treatment of black mothers. Black maternal health is a current public health crisis currently being exacerbated through discrimination in the form of implicit bias. Implicit bias is a current issue in our healthcare system that needs to be addressed through adequate training of both medical students and physicians. This qualitative research …

An Examination Of Cardio-Vascular Patients’ Experiences In A Rural Food Prescription Program, Julia Hansen

Honors Theses

The burden of diet-related chronic diseases in rural communities has prompted the implementation of food prescription programs in rural areas to investigate the impact of more affordable and accessible fresh produce on these vulnerable populations. Because there is little research on the impact of food prescription programs on cardiovascular patients in rural areas, this study will focus on how food prescription programs can benefit this at-risk population. Another goal of this study is to receive feedback from participants to improve food prescription programs to better suit cardiovascular participant needs. To accomplish these goals, a series of questions were asked to …

Benzo[A]Pyrene-Induced Multigenerational Gene Expression And Dna Methylation Changes Are Influenced By Paternal Epigenome, Caroline Sturgis

Honors Theses

The objectives of this study were to determine the sex-dependent contributions to developmental and behavioral effects of preconceptional exposure to benzo[a]pyrene (BaP). BaP is implicated in numerous adverse outcomes in offspring of exposed parents, but the molecular mechanisms for the developmental and multigenerational effects associated with BaP exposures have yet to be fully elucidated. To assess the role of the aryl hydrocarbon receptor (Ahr), a waterborne exposure of the offspring of ahr heterozygous (ahr^+/-) parents was conducted. At 120 hpf, BaP treated fish moved significantly less in the dark phase regardless of genotype. At 3 wpf, there …

The Effects Of Additive Manufacturing On Canine Hind Limb Repairment Surgery, Annabel Keers

Honors Theses

The intention of this project is to explore some of the ways that additive manufacturing is affecting veterinary medicine. I will specifically be delving into canine hind limb repairment surgeries, such as cranial cruciate ligament reconstruction. 3D printed prototypes have been utilized in the human medical field for quite a while, and it has inspired such technology to expand into the world of veterinary medicine. Such emerging research is expected to take-off as the pet market grows in size and level of care for the health of our animals.

I took special interest in this field as I will be …

Moca Normative Data On Young Adults Using An Adapted Version And Remote Administration Via Zoom, Elizabeth Johns

Honors Theses

Overview:

Cognitive decline is often associated with the emergence of dementia and other negative developments in health. Due to the potential for harm that cognitive decline can cause, it is essential that clinicians are able to detect and identify when it is occurring. The Montreal Cognitive Assessment (MoCA) is useful clinically mainly because of the test’s ability to identify mild cognitive impairment. Following the pandemic in 2020, telehealth has become prominent. Previous studies considering MoCA have mostly used samples of older adults, but it is important to understand the impact of traumatic brain injuries on young adults. The following study …

Inotuzumab Ozogamicin For The Treatment Of Adult Acute Lymphoblastic Leukemia: Past Progress, Current Research And Future Directions, Nicholas J Short, Elias Jabbour, Nitin Jain, Hagop Kantarjian

Faculty, Staff and Student Publications

Inotuzumab ozogamicin (INO) is an anti-CD22 antibody-drug conjugate that was first evaluated in B-cell lymphomas but was subsequently shown to be highly effective in acute lymphoblastic leukemia (ALL). INO improved response rates and survival in a randomized study in adults with relapsed/refractory B-cell ALL, leading to its regulatory approval in the United States in 2017. While the formal approval for INO is as monotherapy in relapsed/refractory ALL, subsequent studies with INO administered in combination with chemotherapy and/or blinatumomab both in the frontline and salvage settings have yielded promising results. In this review, we discuss the clinical development of INO in …

Regulation Of Cerebral Blood Flow Boosts Precise Brain Targeting Of Vinpocetine-Derived Ionizable-Lipidoid Nanoparticles, Xufei Bian, Ling Yang, Dingxi Jiang, Adam J Grippin, Yifan Ma, Shuang Wu, Linchong Wu, Xiaoyou Wang, Zhongjie Tang, Kaicheng Tang, Weidong Pan, Shiyan Dong, Betty Y S Kim, Wen Jiang, Zhaogang Yang, Chong Li

Faculty, Staff and Student Publications

Despite advances in active drug targeting for blood-brain barrier penetration, two key challenges persist: first, attachment of a targeting ligand to the drug or drug carrier does not enhance its brain biodistribution; and second, many brain diseases are intricately linked to microcirculation disorders that significantly impede drug accumulation within brain lesions even after they cross the barrier. Inspired by the neuroprotective properties of vinpocetine, which regulates cerebral blood flow, we propose a molecular library design centered on this class of cyclic tertiary amine compounds and develop a self-enhanced brain-targeted nucleic acid delivery system. Our findings reveal that: (i) vinpocetine-derived ionizable-lipidoid …