Medicine and Health Sciences Commons^™

The Perceptions Of A Nurse-Led Telehealth Discharge Program On Continuity Of Care For Pediatric Rheumatology Patients, Adrienne Ramirez

Doctoral Projects

When pediatric rheumatology patients are discharged from a hospital, they are given a complex discharge plan which involves responsibilities in self-managing their care at home. This creates an overwhelming time for patients and families who may have questions or concerns during this time. In order to address this care gap and provide continuity of care, this quality improvement project implemented a nurse-led telehealth discharge visit intervention to 15 pediatric rheumatology patients during the transition from hospital discharge to outpatient care. This quality improvement (QI) project also aims to describe the patients’ perceptions of the nurse-led telehealth discharge intervention on continuity …

The Crosstalk Between Macrophages And Cancer Cells Potentiates Pancreatic Cancer Cachexia, Mingyang Liu, Yu Ren, Zhijun Zhou, Jingxuan Yang, Xiuhui Shi, Yang Cai, Alex X Arreola, Wenyi Luo, Kar-Ming Fung, Chao Xu, Ryan D Nipp, Michael S Bronze, Lei Zheng, Yi-Ping Li, Courtney W Houchen, Yuqing Zhang, Min Li

Faculty, Staff and Student Publications

With limited treatment options, cachexia remains a major challenge for patients with cancer. Characterizing the interplay between tumor cells and the immune microenvironment may help identify potential therapeutic targets for cancer cachexia. Herein, we investigate the critical role of macrophages in potentiating pancreatic cancer induced muscle wasting via promoting TWEAK (TNF-like weak inducer of apoptosis) secretion from the tumor. Specifically, depletion of macrophages reverses muscle degradation induced by tumor cells. Macrophages induce non-autonomous secretion of TWEAK through CCL5/TRAF6/NF-κB pathway. TWEAK promotes muscle atrophy by activating MuRF1 initiated muscle remodeling. Notably, tumor cells recruit and reprogram macrophages via the CCL2/CCR2 axis …

Development Of An International Standard Set Of Outcomes And Measurement Methods For Routine Practice For Adults With Epilepsy: The International Consortium For Health Outcomes Measurement Consensus Recommendations, Martha Sajatovic

Faculty Scholarship

At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. Therefore, the International Consortium for Health Outcomes Measurement (ICHOM) convened an international working group of experts in epilepsy, people with epilepsy and their representatives to develop minimum sets of standardized outcomes and outcomes measurement methods for clinical practice that support patient–clinician decision-making and quality improvement. Consensus methods identified 20 core outcomes. Measurement tools were recommended based on their evidence of strong clinical measurement properties, feasibility, and cross-cultural applicability. The essential outcomes included many non-seizure outcomes: anxiety, depression, suicidality, memory and attention, sleep …

Us Neonatal Intensive Care Unit Registered Dietitian Nutritionists Salary Description And Correlates: Results Of A Survey, Rosa K. Hand, Sharon Groh-Wargo

Faculty Scholarship

Background: This survey described the compensation of neonatal intensive care unit (NICU) registered dietitian nutritionists (RDNs) in the United States and examined correlates of higher salaries within this group. Methods: A cross-sectional online survey was completed in 2021 by 143 NICU RDNs from 127 US hospitals who reported hourly wage in US dollars (USD). We used initial bivariate analyses to assess the relationship of selected institution-level and individual-level variables to hourly wage; the rank-sum test for binary variables; bivariate regression and Pearson correlation coefficients for continuous variables; the Kruskal–Wallis test for categorical variables. Variables with a compelling relationship to the …

Buprenorphine Use For Analgesia In Palliative Care, Leanne K Jackson, Ivy O Poon, Mary A Garcia, Syed Imam, Ursula K Braun

Center for Medical Ethics and Health Policy Staff Publications

Buprenorphine is a semi-synthetic long-acting partial µ-opioid receptor (MOR) agonist that can be used for chronic pain as a sublingual tablet, transdermal patch (Butrans®), or a buccal film (Belbuca®). Buprenorphine’s unique high receptor binding affinity and slow dissociation at the MOR allow for effective analgesia while offering less adverse effects compared to a full agonist opioid, in particular, less concern for respiratory depression and constipation. It is underused in chronic pain and palliative care due to misconceptions and stigma from its use in opioid use disorder (OUD). This case report discusses the unique pharmacology of buprenorphine, including its advantages, disadvantages, …

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests On Respiratory Samples And Stool With Or Without Lateral Flow Lipoarabinomannan Assays To Detect Pulmonary Tuberculosis Disease In Children, Laura Olbrich, Alexander W Kay, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Ruvandhi R Nathavitharana, Andreas Lundh, Maunank Shah, Devan Jaganath

Faculty, Staff and Students Publications

This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To compare the diagnostic accuracy of the parallel use of low-complexity automated nucleic acid amplification tests on respiratory and stool specimens in children and lateral flow urine lipoarabinomannan amongst children with HIV versus each assay alone for detecting pulmonary tuberculosis. Secondary objectives To compare the diagnostic accuracy of low-complexity automated nucleic acid amplification tests on respiratory and stool specimens in combination versus each sample type alone. To investigate the following sources of heterogeneity: clinical setting, signs and symptoms of pulmonary tuberculosis disease, screening positivity by chest …

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests And Lateral Flow Urine Lipoarabinomannan Assays To Detect Tuberculosis Disease In Adults And Adolescents Living With Hiv, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Ruvandhi R Nathavitharana, Laura Olbrich, Devan Jaganath, Alexander W Kay, Andreas Lundh, Maunank Shah

Faculty, Staff and Students Publications

This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity automated nucleic acid amplification tests on respiratory samples versus each test alone for detection of tuberculosis disease in adults and adolescents living with HIV who present with presumptive tuberculosis. Secondary objectives To investigate the following sources of heterogeneity: clinical setting; signs and symptoms of tuberculosis; screening positivity for tuberculosis disease by chest x-ray, C-reactive protein elevation, and molecular World Health Organization-recommended rapid diagnostics; seriously ill; advanced HIV; and CD4 …

High All-Cause Mortality And Increasing Proportion Of Older Adults With Tuberculosis In Texas, 2008–2020, Belinda A. Medrano, Miryoung Lee, Gretchen L. Gemeinhardt, Lana Yamba, Blanca I. Restrepo

School of Medicine Publications

Pulmonary tuberculosis (PTB) elimination efforts must consider the global growth of the ageing population. Here we used TB surveillance data from Texas, United States (2008–2020; total n = 10656) to identify unique characteristics and outcomes in older adults (OA, ≥65 years) with PTB, compared to young adults (YA, 18–39 years) or middle-aged adults (40–64 years). We found that the proportion of OA with PTB increased from 15% in 2008 to 24% in 2020 (trend p < 0.05). Diabetes was highly prevalent in OA (32%) but not associated with adverse outcomes. Death was 13-fold higher in OA compared to YA and was 7% at the time of diagnosis which suggests diagnostic delays. However, once TB was suspected, we found no differences in culture, smear, or nucleic acid detection of mycobacteria (although less lung cavitations) in OA. During treatment, OA had less drug-resistant TB, few adverse reactions and adhered with TB treatment. We recommend training healthcare workers to ‘think TB’ in OA, for prompt treatment initiation to diminish deaths. Furthermore, OA should be added as a priority group to the latent TB treatment guidelines by the World Health Organization, to prevent TB disease in this highly vulnerable group.

Targeting Cathepsin C Ameliorates Murine Acetaminophen-Induced Liver Injury, Jessica Raith, Malte Bachmann, Sina Gonther, Hendrik Stülb, Ali A Aghdassi, Christine T N Pham, Heiko Mühl

2020-Current year OA Pubs

Acetaminophen (APAP) overdosing is a major cause of acute liver failure worldwide and an established model for drug-induced acute liver injury (ALI). While studying gene expression during murine APAP-induced ALI by 3'mRNA sequencing (massive analysis of cDNA ends, MACE), we observed splenic mRNA accumulation encoding for the neutrophil serine proteases cathepsin G, neutrophil elastase, and proteinase-3 - all are hierarchically activated by cathepsin C (CtsC). This, along with increased serum levels of these proteases in diseased mice, concurs with the established phenomenon of myeloid cell mobilization during APAP intoxication.

Radiological And Pulmonary Results Of Surgical Treatment Of Severe Idiopathic Scoliosis Using Preoperative Halo Gravity Traction Compared With Less Invasive Temporary Internal Distraction In Staged Surgery In Adolescents, Pawel Grabala, Michael A Galgano, Michal Grabala, Jacob M Buchowski

2020-Current year OA Pubs

No abstract provided.

Oral Health Education And Dental Care Access Of Families Of Children With Down Syndrome In New Mexico, Alayna Marissa Holcomb

Dental Hygiene ETDs

ABSTRACT

Purpose: The purpose of this study was to assess the oral health education and dental care access of families of children with Down syndrome in New Mexico.

Methods: The data were gathered from a survey available to members of the Rio Grande Down Syndrome Network for 14 days containing 13 questions.

Results: The most reported age range for the individuals in care were 0-14 years at 41.6%. Most individuals with Down syndrome receive dental services every six months (62.5%) at a regular dental office (54.2%). Caregivers reported the individuals are taking 1-2 prescription medications (54.2%) and not aware of …

Standard Rodent Diets Differentially Impact Alcohol Consumption, Preference, And Gut Microbiome Diversity, Aline Zaparte, Evan Dore, Selby White, Franciely Paliarin, Cameron Gabriel, Katherine Copenhaver, Samhita Basavanhalli, Emily Garcia, Rishith Vaddavalli, Meng Luo, Christopher M. Taylor, David Allen Welsh, Rajani Maiya

School of Graduate Studies Faculty Publications

Alcohol use disorder (AUD) is a complex and widespread disease with limited pharmacotherapies. Preclinical animal models of AUD use a variety of voluntary alcohol consumption procedures to recapitulate different phases of AUD, including binge alcohol consumption and dependence. However, voluntary alcohol consumption in mice is widely variable, making it difficult to reproduce results across labs. Accumulating evidence indicates that different brands of commercially available rodent chow can profoundly influence alcohol intake. In this study, we investigated the effects of three commercially available and widely used rodent diet formulations on alcohol consumption and preference in C57BL/6 J mice using the 24 …

Assessing The Reliability Of The Pairwise Variability Index For Differential Diagnosis Of Apraxia Of Speech, Celeste Sinko

University Honors Theses

Differential diagnosis of apraxia of speech (AOS) from other speech and language disorders is a prevailing challenge in the field of speech language pathology. Presently, existing measures for assessing AOS consist of perceptual rating scales, such as the Apraxia of Speech Rating Scale developed by Duffy, Strand, Clark, and Josephs. While perceptual rating scales are the current gold standard for assessment and diagnosis of AOS, they require a high degree of clinical expertise, and are susceptible to rater bias and rater drift. Thus, there exists a need for quantitative, objective measures for differential diagnosis of AOS. The purpose of this …

Exploring Social Workers Potential Role In Mitigating Maternal Mortality Through Coordinated Care, Jena Brown-Talib

Honors Theses

Maternal health disparities persist as a significant challenge in Mississippi, particularly for African American women. This thesis explores the intersection of coordinated care models and social work interventions in addressing maternal mortality. Coordinated care involves collaboration among physicians, nurses, practitioners, social workers, community health workers, and other support services, aiming to maximize pregnant patients' overall health outcomes.

Analyzing strategies of social workers within coordinated care models is important for improving maternal health outcomes within this study. A qualitative approach was chosen to delve beyond statistics and illuminate the reality of maternal health disparities and the efforts to resolve them. Data …

The Impact Of School-Based Education Program On Body Image In Middle School Students, Elizabeth Hendon

Honors Theses

Body dissatisfaction is an emerging public health concern and carries significant health-related consequences. These implications encompass mental health challenges, eating disorders, unhealthy weight management practices, adverse effects on self-esteem, and potential physical health consequences. Because adolescence is a critical period for healthy body image development due to age-related transitions occurring at this time, it is essential to implement an education program to promote positive body image. Educational programs focused on protective factors designed to enhance self-compassion can potentially improve body image, eating attitudes, and body satisfaction. School-based body image education programs aim to provide adolescents with the knowledge, skills, and …

Fixing A Hole: A Retrospective Cohort Study Evaluating Hav, Hbv, Tetanus Screening, And Vaccination During Hospitalization In Persons Who Use Substances, Amber C. Streifel, Jose Eduardo Rivera Sarti, Monica K. Sikka, Michael Conte, Bradie Winders, Cara D. Varley

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background:Rates of serious injection-related infections in persons who use drugs have increased. Resulting admissions are an opportunity for screening and vaccination of preventable infections such as hepatitis A virus (HAV), hepatitis B virus (HBV), and tetanus. Design and methods:We conducted a retrospective review of adults with documented substance use admitted for bacterial infection between July 2015 and March 2020. We evaluated HAV, HBV, and tetanus vaccination status at admission, along with screening for HAV and HBV infection and immunity. We identified the proportion of patients at risk for infection who received HAV, HBV, and tetanus vaccines during admission and patient-level …

Nrf2 Regulates Basal Gluathione Production In Astrocytes, Jiali He

Theses - ALL

In the central nervous system, astrocytes are the primary source of glutathione (GSH), an important and abundant non-protein thiol antioxidant. GSH biosynthesis takes place in the cytosol and involves two sequential steps, the first catalyzed by glutamate cysteine ligase (GCL) and the subsequent by glutathione synthetase (GSS). The process relies heavily on the availability of cysteine, which is obtained through the action of the glutamate/cystine antiporter, System xc-. This transporter imports cystine into the cells, where it is rapidly reduced to cysteine intracellularly for GSH synthesis. Furthermore, the multidrug resistance protein 1 (Mrp1) facilitates the export of GSH from astrocytes …

Basic Structure Of The Pharmacophore Virtual Screening Protein 7kg7 For Candidate Therapeutic Options Covid-19, Ahmad Ridha Al Fiqri

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome, namely coronaviruses (SARS-CoV-2) has been a pandemic to date and is contagious with relatively high mortality rates. Various efforts have been made to control the pandemic to finding the best solution to reduce the spread such as rapid detection based on molecular and serological, as well as efforts to find the best medicine for COVID-19 patients continue to be carried out. We analyzed and concluded that the presatovir compound is capable of being a substitute for the native protein ligand 7KG7, this is proved with a ΔG value of -13.22 kcal/mol …

Examining The Nexus Of Food Insecurity And Oral Health, Abigayle Talbot

Honors Theses

This research paper delves into the relationship between oral health and nutrition status among individuals with food insecurity. As both oral health and nutritional well-being play pivotal roles in overall health, understanding their interplay in the context of food insecurity becomes important. This study investigated how inadequate access to food resources, a characteristic of food insecurity, can impact oral health, leading to a spectrum of dental issues. The study explores the impact of compromised oral health on dietary habits, potentially resulting in nutritional deficiencies or malnutrition. By examining the potential pathways through which these factors influence each other, the study …

Proposals To Address Health Disparities In Occupational Therapy, Madison Michelle Cotten

Honors Theses

Health disparities, “preventable differences in the burden of disease, injury, violence, or opportunities to achieve optimal health,” are infamous for their effects within both general healthcare and occupational therapy settings (Centers for Disease Control and Prevention [CDC], 2008). Though existing literature establishes a need for the widespread adoption of anti-discrimination measures, specific recommendations for occupational therapy schools remain limited. This project aims to remedy this gap in knowledge by serving as an initial overview of healthcare disparities within occupational therapy and by addressing the potential value of incorporating diversity courses into the curriculum of occupational therapy schools. Through the presentation …

Reverse Genetics Of Murine Rotavirus: A Comparative Analysis Of The Wild-Type And Cell-Culture-Adapted Murine Rotavirus Vp4 In Replication And Virulence In Neonatal Mice, Takahiro Kawagishi, Liliana Sánchez-Tacuba, Ningguo Feng, Harry B Greenberg, Siyuan Ding

2020-Current year OA Pubs

Small-animal models and reverse genetics systems are powerful tools for investigating the molecular mechanisms underlying viral replication, virulence, and interaction with the host immune response in vivo. Rotavirus (RV) causes acute gastroenteritis in many young animals and infants worldwide. Murine RV replicates efficiently in the intestines of inoculated suckling pups, causing diarrhea, and spreads efficiently to uninoculated littermates. Because RVs derived from human and other non-mouse animal species do not replicate efficiently in mice, murine RVs are uniquely useful in probing the viral and host determinants of efficient replication and pathogenesis in a species-matched mouse model. Previously, we established an …

Internship In Biological Sciences: Lab Assistant At Twin Cities Dermatopathology, Emma Ryks, Brittany Nairn

Science Symposium

From June to December last year, I served as a Laboratory Assistant at Twin Cities Dermatopathology—an associate of Sonic Healthcare, USA. In this role, I worked under Xiao Xie (TCD’s lab Supervisor) maintaining the lab space. Tasks included managing the intake of slides, quality checking, labeling, staining, and coverslipping the slides, organizing them for pathological assessment, updating the patient records, and storing the slides after processing. This role required much diligence and communicativeness as I became the “reference person” to which the histologists, doctors, accessioners, and data records personnel could come with issues or questions that I could resolve or …

Acute Effects Of Virtual Reality Gameplay On The Visual System: An Observational Study, Aaron Loe, Gavin Rataj, Leah Jackson

Science Symposium

PURPOSE: Virtual reality (VR) has an increasing breadth of utilization, from at home entertainment to a tool used in professional athletic and clinical settings. A review of literature shows altered visual performance (VP) post-VR gameplay in children and adult athletes, particularly in acuity, accommodation and convergence, but has been limited to the immediate effects on vision. This study aims to repeat similar test measures, expanding on aspects of VP, pre- and post-VR gameplay in a healthy, collegiate-aged population, while exploring the feasibility of repeated testing to observe any ocular changes that may occur over time once gameplay has ceased. METHODS: …

Human Gross Anatomy Laboratory Teaching Assistant, Grace Ginter, Jackie Towner

Science Symposium

Over the summer I worked for Bethel University’s Physician Assistant program helping out as a class and laboratory teaching assistant for their human gross anatomy and cadaver lab. My main jobs included basic upkeep and sanitation of the lab and running the class laboratory period. Daily I guided students in their dissection procedures and techniques. Additionally, I helped convey important anatomical knowledge that worked to bridge the gap between lecture material and real-life experience. Outside of lab time myself with the assistance of the other teaching assistants were responsible for the creation and set up of weekly laboratory quizzes and …

Internship At Emergency Physician Professional Association (Eppa), Bryan Tran, Brittany Nairn

Science Symposium

Over the summer, I had the opportunity to start working at EPPA’s scribe program. EPPA is an organization that emphasizes the importance of exposure to the healthcare environment along with developing relationships with different medical professionals. The main aspect of my job was aiding the provider in recording a patient visit with their medical records, physical exams, labs, imaging, patient outcomes, and overall purpose in coming into the emergency room. This job has helped me gain more knowledge about how our healthcare system works and allows me to connect with different providers and scribes. Furthermore, I have gained experience working …

College Student's Attitudes Towards Speech Disorders, Morgan Dean, Joel Frederickson

Science Symposium

This study investigated College Students and their attitudes toward Speech Disorders. The sample consisted of 42 college students from Bethel University aged 18+ or who had an approved parent consent form. Participants participated in this study through the SONA system as part of a research experience assignment or extra credit opportunity for a Bethel University course. The purpose of this study was to find differences in college student's attitudes toward speech disorders.

Synthesis Of Disubstituted Β-Hydroxy Acids For The Enzymatic Synthesis Of Chiral Β-Lactones, Laura Charlotte Underwood, James Christenson

Science Symposium

Beta-lactone synthetases are a class of enzymes which produce chiral beta-lactones, four-membered cyclic esters, from racemic beta-hydroxy acid substrates. Chiral beta-lactones are used as chemical synthons and as bioactive compounds, such as the FDA-approved drug, Orlistat. However, substrate specificity of stand-alone beta-lactone synthetases are poorly understood, and their use in chemoenzymatic synthesis of chiral bioactive compounds remains unexplored. This research focused on the organic synthesis of beta-hydroxy acids to probe the substrate specificity of this class of enzymes and to generate potentially bioactive compounds against essential tuberculosis enzymes. The beta-hydroxy acid 2-[(5-chlorofuran-2-yl)(hydroxy) methyl]hexanoic acid was synthesized from lithiated hexanoate and …

Ankle Mobility And Balance In A Healthy College-Aged Population: A Correlational Study, Anna Johnson, Maddy Roiger, Ellie Stewart, Leah Jackson

Science Symposium

This study aimed to investigate the relationship between ankle mobility and balance in a young, healthy population, filling a gap in existing literature primarily focused on older adults. The findings revealed no significant correlation between ankle mobility and balance measures in the college-aged subjects. While previous research in elderly populations suggested a link between ankle mobility and balance, this study suggests that such a relationship may not hold true for younger individuals. These results underscore the importance of considering age-related differences and overall health status when exploring factors affecting balance, potentially guiding future research and intervention strategies aimed at improving …

The Effect Of Vision On Lower Quarter Balance During Y-Balance Test Testing In College Students, Katelyn Mehr, Nathan Smith, Leah Jackson

Science Symposium

In order to maintain balance and stability, the body relies on the integration of information from the visual, vestibular, and proprioceptive systems. If an individual has an impairment or weakness in one or more systems, their ability to maintain balance may be impaired. Both postural stability and vision contribute to one’s ability to maintain balance in functions of everyday life. The Y-Balance Test (YBT) is a dynamic balance assessment. This study focuses on the visual system and its relation to postural balance, specifically if altered visual states affect one’s ability to maintain balance during a YBT via the use of …

Navigating And Caring For Mental Health In A Group Home Setting, Constance Azonwu, Brian Hyatt

Science Symposium

During my Nursing Assistant internship, I transitioned from classroom learning to real-world caregiving. Guided by an instructor, I further developed practical skills. At Immaculate Homes Care, I faced challenging and new situations, and as a provider, I administered medications and interacted with residents regularly. This experience reinforced the importance of empathy, documentation, and patient care. It also prepared me for my career and boosted my confidence in making decisions.