Medicine and Health Sciences Commons^™

Exploring Caregiver Support For Advanced Practice Nurses Following An Error, Sunnie Lee Nield

Theses and Dissertations

Advanced Practice Registered Nurses (APRN) are a growing population of employed individuals within the healthcare system, working in outpatient and inpatient settings. Like other healthcare professionals, nurse practitioners can and do make errors while practicing. Nevertheless, little to no research has focused on them. This research aimed to better understand nurse practitioners' attitudes towards error approach, perception, and cause using the Medical Error Attitude Scale (MEAS). Additional purposes included the further exploration of APRNs' experiences following an error and support they may or may not receive. A convenience sample of ARPNs licensed in Utah was sent an electronic survey via …

Efficacy And Safety Of Atezolizumab And Bevacizumab In Appendiceal Adenocarcinoma, Nicholas J Hornstein, Mohammad A Zeineddine, Betul B Gunes, Andrew J Pellatt, Mark Knafl, Haifeng Zhu, Anneleis F Willett, Abdelrahman Yousef, Suyu Liu, Ryan Sun, Andrew Futreal, Scott E Woodman, Melissa W Taggart, Michael J Overman, Daniel M Halperin, Kanwal P Raghav, John Paul Shen

Faculty, Staff and Student Publications

PURPOSE: Appendiceal adenocarcinoma (AA) remains an orphan disease with limited treatment options for patients unable to undergo surgical resection. Evidence supporting the efficacy of combined VEGF and PD-1 inhibition in other tumor types provided a compelling rationale for investigating this combination in AA, where immune checkpoint inhibitors have not been explored previously.

EXPERIMENTAL DESIGN: We conducted a prospective, single-arm phase II study evaluating efficacy and safety of atezolizumab in conjunction with bevacizumab (Atezo+Bev) in advanced, unresectable AA.

RESULTS: Patients treated with the Atezo+Bev combination had 100% disease control rate (1 partial response, 15 stable disease) with progression-free survival (PFS) of …

A Framework And Process For Community‑Engaged, Mixed‑Methods Cancer Needs Assessments, Todd Burus, Jessica R. Thompson, Caree R. Mcafee, Lovoria B. Williams, Jennifer R. Knight, Bin Huang, Sarojini Kanotra, Natalie P. Wilhite, Elaine Russell, Melinda Rogers, Connie L. Sorrell, Christine Stroebel, Rachael King, Pamela C. Hull

Markey Cancer Center Faculty Publications

Purpose

Community health needs assessments are required for most state and local public health agencies and non-profit hospitals. Typically based on community health improvement planning models, these assessments encompass overall com- munity health and multiple diseases to inform program planning. National Cancer Institute (NCI)-designated Cancer Centers and community-based cancer-focused programs share the goal of reducing cancer burden in the catchment areas they serve. However, to date, no published models exist to guide cancer-specific needs assessments for a determined geographic area that can inform both public health and research initiatives. The purpose of this article is to outline a cancer needs …

Small-Molecule Disruptors Of The Interaction Between Calcium- And Integrin-Binding Protein 1 And Integrin Α, Kalyan Golla, Adam Yasgar, Manjuprasanna Voddarahally Nagaraju, Meghna U. Naik, Bolormaa Baljinnyam, Alexey V. Zakharov, Sankalp Jain, Ganesha Rai, Ajit Jadhav, Anton Simeonov, Ulhas P. Naik

Cardeza Foundation for Hematologic Research

Thrombosis, a key factor in most cardiovascular diseases, is a major contributor to human mortality. Existing antithrombotic agents carry a risk of bleeding. Consequently, there is a keen interest in discovering innovative antithrombotic agents that can prevent thrombosis without negatively impacting hemostasis. Platelets play crucial roles in both hemostasis and thrombosis. We have previously characterized calcium- and integrin-binding protein 1 (CIB1) as a key regulatory molecule that regulates platelet function. CIB1 interacts with several platelet proteins including integrin αIIbβ3, the major glycoprotein receptor for fibrinogen on platelets. Given that CIB1 regulates platelet function through its interaction with αIIbβ3, we developed …

Evaluating Nurse Medication Education, Nina Marie Carter

Walden Dissertations and Doctoral Studies

Inefficient communication between nurses and patients increases the risk of medication errors and jeopardizes patient safety, ultimately resulting in lower patient satisfaction as indicated by Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores. The purpose of this quality improvement initiative was to assess the impact of educating nurses on patient medication education using the teach-back method. Data were collected using HCAHPS survey responses from adult patients with medical conditions who had been discharged from a medical-surgical unit. The 32-item HCAHPS survey was used to capture their perceptions and experiences during their hospital stay. Data analysis entailed comparing HCAHPS …

Metabolic Alterations And Cellular Responses To Β-Hydroxybutyrate Treatment In Breast Cancer Cells, Hadas Fulman-Levy, Raichel Cohen-Harazi, Bar Levi, Lital Argaev-Frenkel, Ifat Abramovich, Eyal Gottlieb, Sarah Hofmann, Igor Koman, Elimelech Nesher

Faculty, Staff and Student Publications

BACKGROUND: The ketogenic diet (KD), based on high fat (over 70% of daily calories), low carbohydrate, and adequate protein intake, has become popular due to its potential therapeutic benefits for several diseases including cancer. Under KD and starvation conditions, the lack of carbohydrates promotes the production of ketone bodies (KB) from fats by the liver as an alternative source of metabolic energy. KD and starvation may affect the metabolism in cancer cells, as well as tumor characteristics. The aim of this study is to evaluate the effect of KD conditions on a wide variety of aspects of breast cancer cells …

Differential Roles Of Key Brain Regions: Ventral Tegmental Area, Locus Coeruleus, Dorsal Raphe, Nucleus Accumbens, Caudate Nucleus, And Prefrontal Cortex In Regulating Response To Methylphenidate: Insights From Neuronal And Behavioral Studies In Freely Behaving Rats, Nachum Dafny, Catherine Claussen, Emilee Frazier, Yin Liu

Faculty, Staff and Student Publications

A total of 3102 neurons were recorded before and following acute and chronic methylphenidate (MPD) administration. Acute MPD exposure elicits mainly increases in neuronal and behavioral activity in dose–response characteristics. The response to chronic MPD exposure, as compared to acute 0.6, 2.5, or 10.0 mg/kg MPD administration, elicits electrophysiological and behavioral sensitization in some animals and electrophysiological and behavioral tolerance in others when the neuronal recording evaluations were performed based on the animals’ behavioral responses, or amount of locomotor activity, to chronic MPD exposure. The majority of neurons recorded from those expressing behavioral sensitization responded to chronic MPD with further …

Vascular Risk Profile And Changes Of Arterial Hypertension After Surgical Revascularization In Adult Moyamoya Patients, Patrick Haas, Lucas Moritz Wiggenhauser, Jonas Tellermann, Helene Hurth, Daniel Feucht, Marcos Tatagiba, Nadia Khan, Constantin Roder

Faculty, Staff and Student Publications

Moyamoya disease (MMD) is a rare stenoocclusive cerebral vasculopathy often treated by neurosurgical revascularization using extracranial-intracranial bypasses to prevent ischemic or hemorrhagic events. Little is known about the vascular risk profile of adult MMD patients compared to the general population. We therefore analyzed 133 adult MMD patients and compared them with data from more than 22,000 patients from the German Health Update database. Patients with MMD showed an age- and sex-adjusted increased prevalence of arterial hypertension, especially in women between 30 and 44 years and in patients of both sexes between 45 and 64 years. Diabetes mellitus was diagnosed significantly …

An International Phantom Study Of Inter-Site Variability In Technetium-99m Image Quantification: Analyses From The Target Radioembolization Study, Grace Keane, Rob Van Rooij, Marnix Lam, S Cheenu Kappadath, Bilal Kovan, Stephanie Leon, Matthew Dreher, Kirk Fowers, Hugo De Jong

Faculty, Staff and Student Publications

BACKGROUND: Personalised multi-compartment dosimetry based on [

RESULTS: Regarding the LSF, inter-site variation with planar site-specific protocols was minimal, as determined by comparing computed LSF between sites (interquartile range 9.6-10.1%). A standardised protocol did not improve variation (interquartile range 8.4-9.0%) but did improve mean accuracy compared to the site-specific protocols (5.0% error for standardised protocol vs 8.8% error for site-specific protocols). Regarding the CRC, inter-system variation was notable for site-specific SPECT protocols and could not be improved by the standardised protocol (CRC interquartile range for 37 mm sphere 0.5-0.7 and 0.6-0.8 respectively), however the standardised protocol did improve accuracy of …

Prelicensure Nursing Students’ Experiences Of And Reactions To Bullying By Registered Nurses (Rns) In The Clinical Environment, Nancy Chiocchi Mcmorrow

Seton Hall University Dissertations and Theses (ETDs)

Bullying within the clinical environment is a pervasive issue that significantly impacts prelicensure nursing students. The aim of this study was to describe prelicensure nursing students' experiences of and reactions to bullying by registered nurses (RNs) during their clinical experience. The qualitative research design involved narrative analysis of participant stories to gain insights into the nature and consequences of these interactions. The findings revealed that bullying manifested through RNs ignoring students, withholding or not accepting help, making wrongful accusations, and engaging in both verbal and non-verbal mistreatment of students. These experiences led prelicensure nursing students to have decreased self-confidence, compromised …

1 A Phenomenological Study Of The Lived Experiences Of Hospital-Based Physical Therapy Department Leaders’ Most Successful Change Management Initiative, Joseph Patanella

Seton Hall University Dissertations and Theses (ETDs)

ABSTRACT

A phenomenological study of the lived experiences of hospital-based physical therapy department leaders’ most successful change management initiative

Problem: Change management initiatives are consistently employed in healthcare to promote quality care. Of concern is that not all initiatives are successful. Individuals involved in successful change management can offer insight to those approaching initiatives.

Purpose: The purpose of this phenomenological study is to describe the lived experiences of hospital-based physical therapy department leaders’ most successful change management initiative.

Methods: The research design was a qualitative approach. A phenomenological research design was employed, using the voice of a group that has …

Hyperoxia-Induced Mir-195 Causes Bronchopulmonary Dysplasia In Neonatal Mice, Patrick Philpot, Fred Graumuller, Nicole Melchiorre, Varsha Prahaladan, Xander Takada, Srinarmadha Chandran, Melissa Guillermo, David Dickler, Zubair H Aghai, Pragnya Das, Vineet Bhandari

Department of Pediatrics Faculty Papers

Background: Exposure to hyperoxia is an important factor in the development of bronchopulmonary dysplasia (BPD) in preterm newborns. MicroRNAs (miRs) have been implicated in the pathogenesis of BPD and provide a potential therapeutic target. Methods: This study was conducted utilizing a postnatal animal model of experimental hyperoxia-induced murine BPD to investigate the expression and function of miR-195 as well as its molecular signaling targets within developing mouse lung tissue. Results: miR-195 expression levels increased in response to hyperoxia in male and female lungs, with the most significant elevation occurring in 40% O₂ (mild) and 60% O₂ (moderate) BPD. …

Catheter-Based Fetal Cardiac Interventions, Betul Yilmaz Furtun, Shaine Alaine Morris

Faculty, Staff and Students Publications

Fetal cardiac intervention (FCI) is an emerging and rapidly advancing group of interventions designed to improve outcomes for fetuses with cardiovascular disease. Currently, FCI is comprised of pharmacologic therapies (e.g., trans-placental antiarrhythmics for fetal arrhythmia), open surgical procedures (e.g., surgical resection of pericardial teratoma), and catheter-based procedures (e.g., fetal aortic valvuloplasty for aortic stenosis). This review focuses on the rationale, criteria for inclusion, technical details, and current outcomes of the three most frequently performed catheter-based FCI procedures: (1) aortic valvuloplasty for critical aortic stenosis (AS) associated with evolving hypoplastic left heart syndrome (HLHS), (2) atrial septal intervention for HLHS with …

Utilization Of Indocyanine Green (Icg) Fluorescence In Patients With Pediatric Colorectal Diseases: The Current Applications And Reported Outcomes., Elizaveta Bokova, Ismael Elhalaby, Seth Saylors, Irene Isabel P. Lim, Rebecca M. Rentea

Manuscripts, Articles, Book Chapters and Other Papers

In pediatric colorectal surgery, achieving and visualizing adequate perfusion during complex reconstructive procedures are paramount to ensure postoperative success. However, intraoperative identification of proper perfusion remains a challeng. This review synthesizes findings from the literature spanning from January 2010 to March 2024, sourced from Medline/PubMed, EMBASE, and other databases, to evaluate the role of indocyanine green (ICG) fluorescence imaging in enhancing surgical outcomes. Specifically, it explores the use of ICG in surgeries related to Hirschsprung disease, anorectal malformations, cloacal reconstructions, vaginal agenesis, bladder augmentation, and the construction of antegrade continence channels. Preliminary evidence suggests that ICG fluorescence significantly aids in …

Latinas In The United States Facing Healthcare Access Challenges In A Mid-Size Urban Community, Nathan M. Lee, Deborah Kessler

Journal of Global Awareness

This study examines the discrepancies and underlying factors in access to healthcare resources regarding breast and cervical cancer for Latinas in a mid-sized urban midwestern community. A survey was conducted at clinics hosted by a local non-profit organization, and forty participants completed surveys for this study (n=40). Bivariate correlation analysis in SPSS determined that significant positive correlations were found between the subjects’ knowledge of the signs and symptoms of cervical cancer and their knowledge of the recommended frequency of receiving pap smears (p

A Sunday Drive, Grayson Huben

Graduate Medical Education Research Journal

N/A

Residency – A Box Of Crayons, Vicki Hamm

Graduate Medical Education Research Journal

NA

Development Of Takotsubo Cardiomyopathy In 46-Year-Old With Refractory Crohn's Disease, Margarita Pipinos, Andrea Klooz, Maria E. Tecos, Andrew Kamien

Graduate Medical Education Research Journal

Rampant autoimmune disease has the potential to ravage the entirety of the body in a systemic fashion. Rarely, it has been reported for Takotsubo cardiomyopathy develop as a result of refractory inflammatory bowel disease. Balancing the comprehensive cares required to support both the cardiovascular system and treat the underlying autoimmune condition care present unique challenges. Here, we describe a patient who developed late-onset Takotsubo cardiomyopathy after prolonged systemic stress as a result of uncontrolled Crohn’s disease. While this patient unfortunately did succumb to the disease process, it is our hope that highlighting these rare cases may progress care for future …

Management Of Variceal Hemorrhage From Extensive Portal Vein Tumor Thrombus In Hepatocellular Carcinoma And Untreated Pheochromocytoma: A Case Report, Patrick Twohig, Kishan Patel, Tomoki Sempokuya, Chijoke Enweluzo, Lyudmila Muinov, Ishfaq Bhat

Graduate Medical Education Research Journal

Background: Over 600,000 people in the United States (U.S.) have liver cirrhosis. It is estimated that 30% of patients with compensated cirrhosis and 60% of patients with decompensated cirrhosis will develop varices in their lifetime, with an incidence rate of new varices at 9% per year. Fifty percent of patients with esophageal varices will experience bleeding at some time. Pheochromocytoma is a rare catecholamine secreting adrenal gland tumor that occurs in 2-8 people per every 1 million people in the general population. Standard treatment for variceal bleeding includes endoscopic band ligation and/or radiologic embolization along with non-selective beta blockers. However, …

The Strategy For Uprighting A Deep Horizontally Impacted Mandibular Second Molar, Hui-Wen Cheng, Chia-Tze Kao, Chih-Chen Chou, Ching-Yi Tsai, Hsing-Yeh Shen, Wen Ken Tai

Taiwanese Journal of Orthodontics

An orthodontic treatment that involves uprighting of deep horizontally impacted mandibular second molars (MM2) can be a challenging procedure. This case report demonstrates an approach to correct an impacted MM2, specifically in a 21-year-old male patient who presented with a Class II division 2 malocclusion, deep bite, and bilateral maxillary second molars with buccal crossbite. Correction of the impacted MM2 had been achieved using a ramus temporary anchorage device (TAD), which applied pulling and extruding forces along with an uprighting moment. Addressing the deep bite required proclination of incisors, utilization of an intrusion arch for maxillary incisors, and implementation of …

Improved Superelastic Wire (Isw) Treatment For Skeletal Class Iii Malocclusion With Anterior Open Bite And Missing Upper Left Incisor, Chun-Yi Huang, Yung-Hui Chen, Szu-Ying Yu, Hui Tseng, Jian-Hong Yu

Taiwanese Journal of Orthodontics

This article reports the orthodontic treatment using improved superelastic Ti-Ni alloy wire for a non-surgical case of skeletal Class III combined with anterior open bite, posterior crossbite, and missing the tooth 21. The treatment processes included space re-opening for the tooth 21 to facilitate replacement with prosthesis, the application of Class III elastics combined with anterior retraction and active tie-back for space closure. Meanwhile, adjustment of bracket position and wire bending were used for detailing and finishing. Interdisciplinary teamwork with orthognathic surgery and prosthetic expertise enhanced rehabilitation of the tooth 21. After a 38-month treatment, the patient was very satisfied …

An Overview Of Patient Preference When Choosing A Dentist And Orthodontist, Chi Yuo Tee, Johnson Hsin-Chung Cheng, Daniel De-Shing Chen, Chi-Yang Tsai, Od Bayarsaikhan

Taiwanese Journal of Orthodontics

Purpose: The purpose of this study is to provide a better understanding to dentists and orthodontists about patient’s preferences when they are choosing their dentist.

Method: The articles from this study were identified in PubMed, ResearchGate, and ScienceDirect databases. Based on the obtained articles, we classify patient preferences into clinical settings, dentist and orthodontic factors, administration system, and the impact of using social media networks for dental treatment marketing. The inclusion criteria for this literature review includes the articles that related to the topic, published from 2008 till 2023, written in English from PubMed, ResearchGate, and ScienceDirect. The exclusion criteria …

Agenesis Of Mandibular Incisors And Orthodontic Management, S. Lalithapriya, N. Kurunji Kumaran

Taiwanese Journal of Orthodontics

Background: Patients with mandibular incisors agenesis often seek treatment to address both aesthetic and functional concerns. The clinical examination and management for these patients may differ from our standard diagnosis and treatment planning protocols.

Objective: This article aimed to collect and review relevant literatures, discussing the necessity for specific attention to the quantity and location of missing mandibular incisors.

Method and results: An electronic literature search was conducted in PubMed and the Cochrane Central Library, focusing on specific objectives. Relevant articles were identified, resulting in a total of 64 articles after duplicates and irrelevant sources were removed.

Discussion and conclusion: …

Load-Deflection Behaviors Of Superelastic Niti Wires Using Two Bending Test Methods Including Passive Self-Ligating Brackets, Hsiu-Ming Hsu, Kuan-Chung Chen, Chen-Jung Chang, Tzer-Min Lee, Jia-Kuang Liu

Taiwanese Journal of Orthodontics

Purpose: Most load-deflection curves of NiTi wires were obtained by three-point test methods, but only few comparative studies had been reported about load-deflection behaviors of superelastic NiTi wires using three-bracket bending test mothod. The purpose of this study was to compare load-deflection behavior of different superelastic NiTi wires using two different bending test including passive self-ligating brackets.

Materials and methods: The study comprised four groups of superelastic NiTi wires: 0.014-inch ThermoNiTi, 0.014-inch CuNiTi, 0.016 x 0.025-inch ThermoNiTi and 0.016 x 0.025-inch 27°C CuNiTi. Each group had 10 pieces of wires to be tested. Then, three-point bending test and three-bracket bending …

Cortical Bone Thickness For Potential Anchorage Placement In Unilateral Cleft Lip And Palate Patients, Supeepan Boonyarattanasoontorn, Prajak Jariyapongpaiboon

Taiwanese Journal of Orthodontics

Purpose: The aim of this study was to measure the cortical bone thickness of the infrazygomatic crest area in individuals with non-syndromic unilateral cleft lip and palate (UCLP) with maxillary expansion using cone-beam computed tomography (CBCT). Materials and Methods: CBCT scans were obtained from 12 Thai non-syndromic UCLP patients with an average age of 14 years. Five horizontal and 8 vertical reference planes were drawn at the infrazygomatic crest area, and the cortical bone thickness was measured at 40 intersection points on the cleft and non-cleft sides. Results: The mean cortical bone thickness of the 40 measured points was 1.25 …

Maackia Amurensis Seed Lectin (Masl) And Soluble Human Podoplanin (Shpdpn) Sequence Analysis And Effects On Human Oral Squamous Cell Carcinoma (Oscc) Cell Migration And Viability, Ariel C Yin, Cayla J Holdcraft, Eamonn J Brace, Tyler J Hellmig, Sayan Basu, Saumil Parikh, Katarzyna Jachimowska, Evelyne Kalyoussef, Dylan Roden, Soly Baredes, Eugenio M Capitle, David I Suster, Alan J Shienbaum, Caifeng Zhao, Haiyan Zheng, Kevin Balcaen, Simon Devos, Jurgen Haustraete, Mahnaz Fatahzadeh, Gary S Goldberg

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Maackia amurensis lectins serve as research and botanical agents that bind to sialic residues on proteins. For example, M. amurensis seed lectin (MASL) targets the sialic acid modified podoplanin (PDPN) receptor to suppress arthritic chondrocyte inflammation, and inhibit tumor cell growth and motility. However, M. amurensis lectin nomenclature and composition are not clearly defined. Here, we sought to definitively characterize MASL and its effects on tumor cell behavior. We utilized SDS-PAGE and LC-MS/MS to find that M. amurensis lectins can be divided into two groups. MASL is a member of one group which is composed of subunits that form dimers, …

The Santa Clara, 2024-05-28, Santa Clara University

The Santa Clara

No abstract provided.

Physical Therapy For Survivors Of Torture: A Scoping Review, Justine Dee, Nancy Gell, Constance Van Eeghen, Benjamin Littenberg

Department of Physical Therapy Faculty Papers

Background: Torture can result in impaired function, reduced quality of life, and chronic pain. Physical therapy (PT) is recommended for wholistic care of survivors of torture (SOT), however there are limited evidenced-based guidelines. We conducted a scoping review to identify and describe the approach and gaps in knowledge around the PT treatment of SOT.

Methods: We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Nine databases were searched from inception to 2023. Eligible sources were those involving PT treatment for SOT. Extracted data included the source of evidence, PT description, mode …

Pediatric Body Mass Index (Bmi) And Distal Radius Fracture Incidence, Jessica Avila, Tyler Hough, Nikalus Skipp, Amber L. West, Deana Mercer

Western Journal of Orthopaedics

Background: The authors postulate that obesity in children increases the risk of distal radius fracture compared to children who are not obese. Because it is difficult to determine the population at risk, the authors observed the inverse of the rate of obesity in pediatric patients with distal radius fractures in an attempt to determine if there was a difference compared to national data on frequency of obesity in the pediatric population in general. If the rate of obesity was greater in distal radius fractures than the overall population, this would constitute evidence that obesity may increase the risk of distal …

Advancing Objective Mobile Device Use Measurement Inchildren Ages 6–11 Through Built-In Device Sensors: A Proof-Of-Concept Study, Olivia L. Finnegan, Robert Glenn Weaver Med, Phd, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal Ph.D., Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart Mph, Ph.D., Michael W. Beets Med, Mph, Phd, Bridget Armstrong Ph.D.

Faculty Publications

Mobile devices (e.g., tablets and smartphones) have been rapidly integrated into the lives of children and have impacted howchildren engage with digital media. The portability of these devices allows for sporadic, on-demand interaction, reducing theaccuracy of self-report estimates of mobile device use. Passive sensing applications objectively monitor time spent on a givendevice but are unable to identify who is using the device, a significant limitation in child screen time research. Behavioralbiometric authentication, using embedded mobile device sensors to continuously authenticate users, could be applied toaddress this limitation. This study examined the preliminary accuracy of machine learning models trained on iPad …