Medicine and Health Sciences Commons^™

Menstrual Personal Hygiene Behavior Among Adolescents With Physical And Intellectual Disabilities, Nur Khotimah Elfiyani, Agustin Kusumayati, Caroline Endah Wuryaningsih, Kemal Nazaruddin Siregar

Kesmas

Reproductive health for adolescents with disabilities is often disregarded, and education on personal hygiene is insufficient because some people perceive menstruation as a sensitive topic and have a false belief that adolescents with disabilities have no sexual desire. This study aimed to determine the overview of personal hygiene behavior among adolescents with physical and intellectual disabilities when facing menstruation. The method used was qualitative, with case studies, in-depth interviews, and observations for data collection. The informants comprised four adolescents aged 19-21 years, two mothers, and two therapists for special needs children. This study was conducted at two growth and development …

Prevention Of Hiv Transmission Among Men Who Have Sex With Men And Compliance With Sexual Protective Equipment, Rico Januar Sitorus, Nurafni Octavia, Merry Natalia Panjaitan, Anita Rahmiwati Rahmiwati, Rizma Adlia Syakurah, Danny Aerosta, Reymart V Sangalang, Yusri Yusri

Kesmas

Sexual orientations, such as gay, lesbian, and bisexual, are prevalent among individuals at high risk of experiencing mental health problems, including drug use, depression, emotional distress, and suicide. Therefore, this study aimed to assess the compliance of men who have sex with men with protective equipment and determine the dominant influential factors. This cross-sectional study included 187 men who had sexual intercourse with men who were recruited from two foundations based in Palembang City, Indonesia, focusing on people living with HIV/AIDS. Data were analyzed using Chi-square and binomial logistic regression. In this context, 50.8% of men who have sexual intercourse …

Conceptualizing Recovery From Mental Illness In Indonesia: A Scoping Review, Flora Cohen, Agus Sugianto, Hans Pols, Clement Bayetti

Makara Human Behavior Studies in Asia

Understanding how recovery is defined and realized across different cultural contexts is vital to upholding the dignity and rights of people with mental illnesses. Within the Indonesian context, there is a dearth of research on conceptualizations of recovery from mental illnesses. Questions remain regarding the extent to which service users and providers share common definitions of recovery. We conducted a scoping review to interrogate current definitions of recovery from the perspectives of the various actors working with people with lived experiences of mental illness and extreme mental distress. We found that definitions of recovery differ across multiple domains and include …

Development And Validity Of The ‘Modified Mediterranean Prime Screen’ To Assess Dietary Intake Among Women Of Reproductive Age In Lebanon, Mariam Assaad, Sara Ajjour, Maya Rahme, Laila Al-Shaar, Hala Ghattas Ph.D., Ghada El-Hajj Fuleihan, Jana Jabbour

Faculty Publications

The Mediterranean Region registers an increasing prevalence of obesity. The region lacks a diet screener to assess obesogenic nutrients. This study aimed to evaluate the reproducibility and validity of the Modified Mediterranean Prime Screen (MMPS) in estimating obesogenic nutrients’ intake among women of reproductive age, as compared with a culturally validated Food Frequency Questionnaire (FFQ), in Lebanon. We developed the MMPS consisting of thirty-two food/beverage items specific to the Lebanese Mediterranean culture. The MMPS and FFQ were administered in two visits (2 weeks–6 months apart), face to face and via telephone during the coronavirus disease 2019 pandemic. The reproducibility and …

Which North American Spine Society Disc Herniation Morphology Descriptors Are Most Associated With Improvements In Clinical Outcomes After Microdiscectomy?, Rajkishen Narayanan, Teeto Ezeonu, Jeremy C. Heard, Yunsoo A. Lee, Caleb M. Yeung, Tyler Henry, Alec Kellish, Meera Kohli, Jose A. Canseco, Mark F. Kurd, Alan S. Hilibrand, Alex R. Vaccaro, Gregory Schroeder, Christopher Kepler, Ian David Kaye

Rothman Institute Papers

BACKGROUND: The North American Spine Society (NASS) assembled the first ever comprehensive naming system for describing lumbar disc disease, including lumbar disc herniation. The objectives of this study were (1) to determine which NASS descriptors are most predictive of independent patient-reported outcomes after microdiscectomy and (2) to identify the inter-rater reliability of each NASS descriptor.

METHODS: Adult patients (≥18 years) who underwent a lumbar microdiscectomy from 2014-2021 were retrospectively identified. Patient-reported outcome measures (PROMs) were collected at preoperative, 3-month, and 1-year postoperative time points. Lumbar disc herniations were evaluated and classified on preoperative MRI using the NASS lumbar disc nomenclature …

Examining The Association Of Type 2 Diabetes Mellitus Risk Factors Between African Immigrants Living In The United States And African Americans Born In The United States, Philip Effiong

Walden Dissertations and Doctoral Studies

The purpose of the study was to investigate the risk factors for Type 2 diabetes mellitus (T2DM) among African immigrants and African Americans born in the United States to identify differences and similarities in their impact and prevalence. Variables considered as potential differentiators included alcohol consumption, income, educational levels, and smoking habits, age, and gender. The health belief model served as the theoretical framework. Utilizing data from the National Health and Nutrition Examination Survey 2015-2016, logistic regression analyses were used to test for significant factors affecting T2DM prevalence in these groups. Results indicated that country of origin did not predict …

A Qualitative Exploration Of Factors Associated With Covid-19 Vaccine Uptake And Hesitancy In Selected Rural Communities In Kenya, Fletcher J. Njororai, Walter Amulla, Caleb Kogutu Nyaranga, Wilberforce Cholo, Toluwani Adekunle

Health & Kinesiology Faculty Publications and Presentations

Purpose: The post-pandemic management of COVID-19 infections and any emergent outbreaks is because this endemic disease remains a public health concern. Vaccine hesitancy may continue to hamper efforts to respond to any new disease outbreaks and future epidemics. This qualitative study aimed to explore the factors influencing COVID-19 vaccine acceptance and hesitancy in Kenya to gain deeper insights into this issue. Methods: This study was implemented in western Kenya using key informant interviews. Fourteen (14) key informants were purposively selected for this study. All interviews were transcribed and analyzed using thematic analysis. The interpretation of findings was conducted within the …

Performance Of Stunting Reduction Acceleration Team: An Explorative-Qualitative Study In Indonesia-Timor Leste Border Area, Maria Paula Marla Nahak, Veronika Nitsae

Kesmas

Stunting is a complex issue influenced by multiple factors, including specific factors within and outside the health sector. Achieving a significant reduction in stunting needs the involvement of relevant local government offices in the Stunting Reduction Acceleration Team (SRAT). This study aimed to investigate SRAT performance in a specific context of accelerating stunting reduction in Malaka District. This qualitative study, with a phenomenological approach, was conducted in Malaka District, Indonesia, and Timor Leste Border Area from July to September 2023. This study revealed four major themes of SRAT performance to accelerate stunting reduction in Malaka District: activities to accelerate stunting …

Vaccine Uptake And Intentions: Insights From A Texas Survey On Factors Influencing Covid-19 Vaccination Decisions, Yordanos M. Tiruneh, Paula M. Cuccaro, Kimberly S. Elliott, Jing Xie, Journey Martinez, Mark Owens, Christian R. Alvarado, Jose-Miguel Yamal

School of Medicine Faculty Publications and Presentations

The effectiveness of COVID-19 vaccines depends on widespread vaccine uptake. Employing a telephone-administered weighted survey with 19,502 participants, we examined the determinants of COVID-19 vaccine acceptance among adults in Texas. We used multiple regression analysis with LASSO-selected variables to identify factors associated with COVID-19 vaccine uptake and intentions to receive the vaccine among the unvaccinated. The prevalence of unvaccinated individuals (22%) was higher among those aged 18–39, males, White respondents, English speakers, uninsured individuals, those facing financial challenges, and individuals expressing no concern about contracting the illness. In a fully adjusted regression model, higher odds of being unvaccinated were observed …

Nursing Students’ Attitudes Regarding Technical Standards For Entrance Into A Bachelor Of Science In Nursing Program, Jordyn Leigh Cook

Institute for Disability Studies

Admission into a Bachelor of Science in Nursing program requires students to meet specific criteria including a non-negotiable set of technical standards. Technical standards encompass physical abilities including twisting, bending, and handling objects of varying weights (Good Samaritan College of Nursing and Health Science, n.d.). While physical capabilities may hold significance in bedside nursing, the American Nurses Association does not establish specific physical qualifications (American Nurses Association, 2010). Due to admission criteria and technical standards, individuals with disabilities are rarely found among career nurses and nursing students (Leslie & Miller, 2020). This study aims to determine nursing students’ attitudes towards …

Spatial Durbin Model On The Utilization Of Delivery At Health Facilities: A 2017 Indonesian Demographic And Health Survey Analysis, Indah Sri Wahyuni, Ira Gustina, Martya Rahmaniati Makful, Tris Eryando

Kesmas

The utilization of delivery at health facilities is a major intervention in reducing 16 to 33% of deaths. This study aimed to determine the model of utilization of delivery at health facilities in Indonesia in 2017 and its influential factors. This study used secondary data from the 2017 Indonesian Demographic and Health Survey using a Spatial Durbin Model (SDM) approach. The population was mothers aged 15 – 49 years, spread across 34 provinces of Indonesia, and had 15,321 samples. The results showed that the Moran’s I value was positive (0.146) and significant at p-value = 0.007, indicating clustered regions with …

Mapping For Tracking Sexually Transmitted Infections By Subdistricts In Surabaya, Indonesia, Destri Susilaningrum, Brodjol Sutijo Suprih Ulama, Fausania Hibatullah, Diandra Soja Anjani

Kesmas

The 2014 shutdown localization of prostitution in Surabaya City, East Java Province, Indonesia, has given rise to an illegal prostitution industry, resulting in the spread of uncontrolled sexually transmitted infections (STIs). Mapping needs to be done to track the spread of the disease. This study used secondary data on STIs in 2020 from the Surabaya City Health Office. By using biplot analysis, this study sought to offer a detailed understanding of the distribution and dynamics of STI cases in different parts of Surabaya. The early-stage syphilis was found in Tegalsari and Krembangan Subdistricts; then, gonorrheal urethritis was found in Tandes, …

Exploring The Implementation Of Safety Resilience Assessment In Industries: A Systematic Literature Review, Mufti Wirawan, Fatma Lestari, Zulkifli Djunaidi, Azka Hafia, Agra Mohamad Khaliwa, Muhammad Schehan Al Azhar

Kesmas

Safety Resilience discusses how a work process can run properly not only aims at preventing adverse events, but also increasing work productivity and effectiveness by increasing resilience. The concept of resilience has been widely suggested as safety management due to its ability to support organizations to continue operating even when facing unexpected demands or scale disruptions by improving their day-to-day performance. This study used a systematic literature review to explore the implementation of safety resilience in various industries. The results showed that 50% of articles used the Resilience Assessment Grid instrument to measure safety resilience in the workplace. In brief, …

Exploring The Multifaceted Nature Of Occupational Stress Among Nurses: A Systematic Review, Bala Murali Sundram, Suriya Kumareswaran Vallasamy, Umairah Muhadi

Kesmas

This systematic review examined occupational stress among nurses, its multifaceted nature, and its significant impact on healthcare delivery and nurse well-being globally. This study identified various stressors, including intrinsic job factors, organizational structure, role expectations, interpersonal relationships, and career development. Using the Cooper and Marshall stress model, a thorough literature search was conducted across databases like ISI Web of Knowledge, PubMed, Scopus, Ovid Medline, and Google Scholar, focusing on publications from 2010 to 2023. This rigorous approach included diverse research methodologies, emphasizing studies measuring outcomes related to occupational stress and mental health among nurses. A total of 10 studies met …

Analysis Of Factors Affecting Hospital Risk Management In Indonesia: The Sem-Pls Approach, Dihartawan Dihartawan, Fatma Lestari, Baiduri Widanarko, Besral Besral

Kesmas

Healthcare workers, especially those in hospitals, face a variety of complex hazards and exposures. One of the essential aspects of reducing risks and dangers is effective risk management. This study used a cross-sectional approach to survey the implementation of occupational health and safety management systems in Indonesian hospitals and to identify factors predisposing hospital risk management in Indonesia. A purposive sampling method was employed to select 90 hospitals distributed across 10 provinces in Indonesia. Data were analyzed using descriptive analysis, correlation, and SEM-PLS. A total of 44 hospitals (48.9%) had complete status plenary, and the majority were type C hospitals …

Factors Associated With Incomplete Resection For Large, Locally Invasive Non-Small Cell Lung Cancer, Whitney S. Brandt, Zhizhou Yang, Brendan T. Heiden, Pamela P. Samson, Daniel Morgensztern, Saiama N. Waqar, Bryan F. Meyers, Ruben G. Nava, G. Alexander Patterson, Benjamin D. Kozower, Varun Puri

2020-Current year OA Pubs

BACKGROUND: Large, node-negative but locally invasive non-small cell lung cancer (NSCLC) is associated with increased perioperative risk but improved survival if a complete resection is obtained. Factors associated with positive margins in this population are not well-studied.

METHODS: We performed a retrospective cohort study using National Cancer Database (NCDB) for adult patients with >5 cm, clinically node-negative NSCLC with evidence of invasion of nearby structures [2006-2015]. Patients were classified as having major structure involvement (azygous vein, pulmonary artery/vein, vena cava, carina/trachea, esophagus, recurrent laryngeal/vagus nerve, heart, aorta, vertebrae) or chest wall invasion (rib pleura, chest wall, diaphragm). Our primary outcome …

Charting A Path To The Quintuple Aim: Harnessing Ai To Address Social Determinants Of Health, Yash Shah, Zachary Goldberg, Erika Harness, David Nash

College of Population Health Faculty Papers

The Quintuple Aim seeks to improve healthcare by addressing social determinants of health (SDOHs), which are responsible for 70-80% of medical outcomes. SDOH-related concerns have traditionally been addressed through referrals to social workers and community-based organizations (CBOs), but these pathways have had limited success in connecting patients with resources. Given that health inequity is expected to cost the United States nearly USD 300 billion by 2050, new artificial intelligence (AI) technology may aid providers in addressing SDOH. In this commentary, we present our experience with using ChatGPT to obtain SDOH management recommendations for archetypal patients in Philadelphia, PA. ChatGPT identified …

Evaluation And Treatment Of Gastrointestinal Bleeding In Patients Taking Anticoagulants Presenting To The Emergency Department., Adam J Singer, Neena S Abraham, Latha Ganti, W Frank Peacock, Janaé Dark, Hajirah Ishaq, Ana Negrete, Brandon Mount, James Neuenschwander

Trauma and Acute Care Articles

This manuscript is a consensus document of an expert panel on the Evaluation and Treatment of Gastrointestinal Bleeding in Patients Taking Anticoagulants Presenting to the Emergency Department, sponsored by the American College of Emergency Physicians.

Vaccine Uptake And Intentions: Insights From A Texas Survey On Factors Influencing Covid-19 Vaccination Decisions, Yordanos M Tiruneh, Paula M Cuccaro, Kimberly S Elliott, Jing Xie, Journey Martinez, Mark Owens, Christian R Alvarado, Jose-Miguel Yamal

Faculty, Staff and Student Publications

The effectiveness of COVID-19 vaccines depends on widespread vaccine uptake. Employing a telephone-administered weighted survey with 19,502 participants, we examined the determinants of COVID-19 vaccine acceptance among adults in Texas. We used multiple regression analysis with LASSO-selected variables to identify factors associated with COVID-19 vaccine uptake and intentions to receive the vaccine among the unvaccinated. The prevalence of unvaccinated individuals (22%) was higher among those aged 18-39, males, White respondents, English speakers, uninsured individuals, those facing financial challenges, and individuals expressing no concern about contracting the illness. In a fully adjusted regression model, higher odds of being unvaccinated were observed …

Prediction Accuracy Of Soil Chemical Parameters By Field- And Laboratory-Obtained Vis-Nir Spectra After External Parameter Orthogonalization, Konrad Metzger, Frank Liebisch, Juan M Herrera, Thomas Guillaume, Luca Bragazza

Faculty, Staff and Student Publications

One challenge in predicting soil parameters using in situ visible and near infrared spectroscopy is the distortion of the spectra due to soil moisture. External parameter orthogonalization (EPO) is a mathematical method to remove unwanted variability from spectra. We created two different EPO correction matrices based on the difference between spectra collected in situ and, respectively, spectra collected from the same soil samples after drying and sieving and after drying, sieving and finely grinding. Spectra from 134 soil samples recorded with two different spectrometers were split into calibration and validation sets and the two EPO corrections were applied. Clay, organic …

Use Of Internet Resources Among Mbbs/Bds Students: The Case Of Clinical Students In A Medical School In Nigeria, Samuel Bello

Library Philosophy and Practice (e-journal)

Background: The Internet has been identified as a multipurpose technology that has become the world’s biggest library where information resources can be accessed with a simple mouse click away. The immense contributions of the tool in academia necessitated the efforts of some universities and Colleges to create an enabling environment, such as low or no-cost Internet access, for new students who need an Internet connection to survive on campus. This study investigated the Use of Internet Resources among MBBS/BDS Students: The Case of Clinical Students in a Medical School in Nigeria

Objectives: This study aimed to investigate the use of …

Combination Treatment Of Biochanin A And Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism And Inducing Cell Cycle Arrest In Pancreatic Cancer Cells, Vilas Desai, Satya Murthy Tadinada, Hoora Shaghaghi, Ross Summer, James C.K. Lai, Alok Bhushan

College of Pharmacy Faculty Papers

Background/Aim: Pancreatic cancer is an aggressive type of cancer, with a dismally low survival rate of <5%. FDA-approved drugs like gemcitabine have shown little therapeutic success, prolonging survival by a mere six months. Isoflavones, such as biochanin A and daidzein, are known to exhibit anti-cancer activity, whereas statins reportedly have anti-proliferative effects. This study investigated the effects of combination treatment of biochanin A and atorvastatin on pancreatic cancer cells.

Materials and Methods: Pancreatic cancer cells AsPC-1, PANC-1, and MIA PaCa-2 were procured from ATCC. The cell viability studies were carried out using MTT & cell count assays. Flow cytometry was used to study cell apoptosis whereas cell metabolism studies were carried out using the Seahorse Mito stress test and XF-PMP assay. The effects of treatment on cell signaling pathways & cell cycle associated proteins were investigated using western blot whereas invasiveness of cancer cells was evaluated using gelatin zymography.

Results: The combination treatment …

Tendinopathy Severity Assessment–Achilles (Tendins-A): Evaluation Of Reliability And Validity In Accordance With Cosmin Recommendations, Myles C. Murphy, Fergus Mccleary, Dana Hince, Ruth Chimenti, Paola Chivers, J. Turner Vosseller, Sophia Nimphius, Nonhlanhla S. Mkumbuzi, Peter Malliaras, Nicola Maffulli, Robert J. De Vos, Ebonie K. Rio

Research outputs 2022 to 2026

Objective To evaluate the construct validity (structural validity and hypothesis testing), reliability (test–retest reliability, measurement error and internal consistency) and minimal important change (MIC) of the 13-item TENDINopathy Severity assessment–Achilles (TENDINS-A). Methods Participants with Achilles pain completed an online survey including: demographics, TENDINS-A, Foot and Ankle Outcome Score (FAOS) and Victorian Institute of Sport Assessment–Achilles (VISA-A). Exploratory factor analysis (EFA) assessed dimensionality. Confirmatory factor analysis (CFA) assessed structural validity (root mean square error of approximation (RMSEA); Comparative Fit Index (CFI); Tucker-Lewis Index (TLI); standardised root measure square (SRMS)). Correlations between TENDINS-A and the FAOS or VISA-A assessed hypothesis testing. Intraclass …

Exploring Counseling Self-Efficacy Development Among Graduate Speech-Language Pathology Students, Rebecca Jones

Dissertations, 2020-current

Two thematically linked studies are contained within this dissertation document, completed in partial fulfillment of the degree requirements for the Doctor of Philosophy, per the Communication Sciences and Disorders Ph.D. handbook, and in agreement with an advisory committee. These projects serve to advance the scholarship of teaching and learning in the areas of counseling skill development and therapeutic alliance building. The first study deals with the impact of a university-based caregiver coaching program on SLP graduate students' counseling self-efficacy (CSE) and their perceptions of therapeutic alliances with infant caregivers. A mixed-methods approach was employed utilizing reflexive thematic analysis (RTA) and …

Individual Longitudinal Changes In Dna-Methylome Identify Signatures Of Early-Life Adversity And Correlate With Later Outcome, Annabel K. Short, Ryan Weber, Noriko Kamei, Christina Wilcox Thai, Hina Arora, Ali Mortazavi, Hal S. Stern, Laura M. Glynn, Tallie Z. Baram

Psychology Faculty Articles and Research

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas the enduring impact of ELA on cognitive and emotional health is established, there are no tools to predict vulnerability to ELA consequences in an individual child. Epigenetic markers including peripheral-cell DNA-methylation profiles may encode ELA and provide predictive outcome markers, yet the interindividual variance of the human genome and rapid changes in DNA methylation in childhood pose significant challenges. Hoping to mitigate these challenges we examined the relation of several ELA dimensions to DNA methylation changes and outcome using a within-subject longitudinal design and a high methylation-change threshold. …

Two Genome-Wide Interaction Loci Modify The Association Of Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer, David A Drew, Andre E Kim, Yi Lin, Conghui Qu, John Morrison, Juan Pablo Lewinger, Eric Kawaguchi, Jun Wang, Yubo Fu, Natalia Zemlianskaia, Virginia Díez-Obrero, Stephanie A Bien, Niki Dimou, Demetrius Albanes, James W Baurley, Anna H Wu, Daniel D Buchanan, John D Potter, Ross L Prentice, Sophia Harlid, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Andrea Burnett-Hartman, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Jenny Chang-Claude, David V Conti, Matthew A M Devall, Jane C Figueiredo, Stephen B Gruber, Andrea Gsur, Marc J Gunter, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Mark A Jenkins, Kristina M Jordahl, Anshul Kundaje, Loic Le Marchand, Li Li, Brigid M Lynch, Neil Murphy, Rami Nassir, Polly A Newcomb, Christina C Newton, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Rish K Pai, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, Gad Rennert, Edward Ruiz-Narvaez, Lori C Sakoda, Peter C Scacheri, Stephanie L Schmit, Robert E Schoen, Mariana C Stern, Yu-Ru Su, Duncan C Thomas, Yu Tian, Konstantinos K Tsilidis, Cornelia M Ulrich, Caroline Y Um, Fränzel J B Van Duijnhoven, Bethany Van Guelpen, Emily White, Li Hsu, Victor Moreno, Ulrike Peters, Andrew T Chan, W James Gauderman

Faculty, Staff and Student Publications

Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit

Correction: Ver-Net: A Hybrid Transfer Learning Model For Lung Cancer Detection Using Ct Scan Images, Anindita Saha, Shahid Mohammad Ganie, Pijush Kanti Dutta Pramanik, Rakesh Kumar Yadav, Saurav Mallik, Zhongming Zhao

Faculty, Staff and Student Publications

No abstract provided.

The Kat Module Of The Saga Complex Maintains The Oncogenic Gene Expression Program In Mycn- Amplified Neuroblastoma, Clare F Malone, Nathaniel W Mabe, Alexandra B Forman, Gabriela Alexe, Kathleen L Engel, Ying-Jiun C Chen, Melinda Soeung, Silvi Salhotra, Allen Basanthakumar, Bin Liu, Sharon Y R Dent, Kimberly Stegmaier

Faculty, Staff and Student Publications

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN-amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic transcriptional program. We characterized the DNA recruitment sites of the SAGA complex in neuroblastoma and the consequences of loss of SAGA complex lysine acetyltransferase (KAT) activity on histone acetylation and gene expression. We demonstrate that loss of SAGA complex KAT activity is associated with reduced MYCN binding on chromatin, suppression of …

Using Patient-Specific 3d Modeling And Simulations To Optimize Microwave Ablation Therapy For Liver Cancer, Amirreza Heshmat, Caleb S O'Connor, Jessica Albuquerque Marques Silva, Iwan Paolucci, Aaron Kyle Jones, Bruno C Odisio, Kristy K Brock

Faculty, Staff and Student Publications

Microwave ablation (MWA) of liver tumors presents challenges like under- and over-ablation, potentially leading to inadequate tumor destruction and damage to healthy tissue. This study aims to develop personalized three-dimensional (3D) models to simulate MWA for liver tumors, incorporating patient-specific characteristics. The primary objective is to validate the predicted ablation zones compared to clinical outcomes, offering insights into MWA before therapy to facilitate accurate treatment planning. Contrast-enhanced CT images from three patients were used to create 3D models. The simulations used coupled electromagnetic wave propagation and bioheat transfer to estimate the temperature distribution, predicting tumor destruction and ablation margins. The …

Nivolumab Plus Relatlimab In Patients With Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase Ii Checkmate 142 Study, Michael J Overman, Fabio Gelsomino, Massimo Aglietta, Mark Wong, Maria Luisa Limon Miron, Gregory Leonard, Pilar García-Alfonso, Andrew G Hill, Antonio Cubillo Gracian, Eric Van Cutsem, Bassel El-Rayes, Stephen M Mccraith, Beilei He, Ming Lei, Sara Lonardi

Faculty, Staff and Student Publications

BACKGROUND: Programmed death-1 (PD-1) inhibitors, including nivolumab, have demonstrated long-term survival benefit in previously treated patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (CRC). PD-1 and lymphocyte-activation gene 3 (LAG-3) are distinct immune checkpoints that are often co-expressed on tumor-infiltrating lymphocytes and contribute to tumor-mediated T-cell dysfunction. Relatlimab is a LAG-3 inhibitor that has demonstrated efficacy in combination with nivolumab in patients with melanoma. Here, we present the results from patients with MSI-H/dMMR metastatic CRC treated with nivolumab plus relatlimab in the CheckMate 142 study.

METHODS: In this open-label, phase II study, previously treated patients with MSI-H/dMMR metastatic CRC …