Medicine and Health Sciences Commons^™

Audiological Evaluation Of Persons With Dementia: A Systematic Review, Yehudis Hoch

Dissertations, Theses, and Capstone Projects

Background: Dementia and hearing loss are both prevalent, age-related conditions and recent research has established a correlation between the two. Audiological evaluations of persons with dementia are important due to a likely comorbidity of dementia and hearing loss, the detrimental effect that hearing loss has on cognition and cognitive tests, and because the similar presentation of the two conditions can cause hearing loss to be overlooked. Hearing loss intervention is critical for this population due to the positive effects that amplification has on cognition, social engagement, and listening effort. Despite the importance of hearing assessment and intervention, audiological evaluation of …

The Effect Of Personal Listening Devices On Subjective Hearing Status, Esther Feldman

Dissertations, Theses, and Capstone Projects

Long term or brief exposure to loud noise can trigger the onset of noise-induced hearing loss which can lead to a temporary (TTS) or permanent (PTS) shift in hearing threshold. Occupational noise, or recreational noise such as music can contribute to shifts in hearing levels. Listening to music in person at a concert or when listening on earphones/earbuds and streaming from a smartphone can produce sound pressure levels (SPL) high enough to lead to PTS, TTS, and associated symptoms. A survey of adults was conducted to gain insight into onset of self-perceived temporary hearing loss and tinnitus after short term …

The Impact Of Sport-Related Concussions On The Vestibular System Utilizing The Vestibular Ocular Motor Screening (Voms) Tool: A Systematic Review For Audiologists, Tina M. Ceriello

Dissertations, Theses, and Capstone Projects

Objective: This systematic review aims to analyze vestibular side effects of sport-related concussions (SRCs) based on differences such as age, gender, and/or sport when using the VOMS tool, and how audiologists may adapt practice for such individuals who have sustained SRCs.

Methods: A comprehensive search identified relevant articles using Google Scholar, ASHAWire, and other databases through the City University of New York (CUNY) Mina Rees Library website. Studies were included if SRCs were evaluated using the complete seven-item VOMS tool and had 25 or more participants. Studies were excluded if concussions were not sport-related, brain injuries were more severe than …

Positron Emission Tomography In Oncology And Environmental Science, Samantha Delaney

Dissertations, Theses, and Capstone Projects

The last half century has played witness to the onset of molecular imaging for the clinical assessment of physiological targets. While several medical imaging modalities allow for the visualization of the functional and anatomical properties of humans and living systems, few offer accurate quantitation and the ability to detect biochemical processes with low-administered drug mass doses. This limits how physicians and scientists may diagnose and treat medical issues, such as cancer, disease, and foreign agents.

A promising alternative to extant invasive procedures and suboptimal imaging modalities to assess the nature of a biological environment is the use of positron emission …

Family Fragments: Pressure And Proximity In First-Episode Psychosis, Cassandra B. Seltman

Dissertations, Theses, and Capstone Projects

This study explores the value of assuming a position that decenters the identified patient in families with a member with schizophrenia. Instead, a systemic view of the family is taken, as subject to pressures from without and within, and utilizing observable processes for the management and discharge of tension. It attempts the difficult balance of thinking dynamically without sacrificing scientific rigor, considering the social without discounting the biological, and exploring the functionality of the family without collapsing into blame, reductive cause-and-effect thinking, and the search to prioritize one true origin.

When treating family members as discrete units around an identified …

Best Practices For Healthcare Providers When Communicating With Individuals With Hearing Loss: A Systematic Review, Ashley Mccaig

Dissertations, Theses, and Capstone Projects

Objectives: The purpose of this study is to conduct a systematic review of the literature to gather information about strategies to use when communicating with people with hearing loss, specifically in healthcare settings or environments where face masks are frequently used. The compiled literature was used to establish the best practices for healthcare providers to use when communicating with their patients with hearing loss, especially when utilizing face masks.

Methods: A comprehensive search of the literature was conducted using the Google Scholar, PubMed, and MEDLINE Complete databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used to …

Cardiovascular Imaging, Climate Change, And Environmental Sustainability., Suvai Gunasekaran, Andrew Szava-Kovats, Thomas Battey, Jonathan Gross, Eugenio Picano, Subha V Raman, Emil Lee, Malenka M Bissell, Mirvat Alasnag, Adrienne E Campbell-Washburn, Kate Hanneman

Heart and Vascular Articles

Environmental exposures including poor air quality and extreme temperatures are exacerbated by climate change and are associated with adverse cardiovascular outcomes. Concomitantly, the delivery of health care generates substantial atmospheric greenhouse gas (GHG) emissions contributing to the climate crisis. Therefore, cardiac imaging teams must be aware not only of the adverse cardiovascular health effects of climate change, but also the downstream environmental ramifications of cardiovascular imaging. The purpose of this review is to highlight the impact of climate change on cardiovascular health, discuss the environmental impact of cardiovascular imaging, and describe opportunities to improve environmental sustainability of cardiac MRI, cardiac …

Treatment Of Recalcitrant Hailey-Hailey Disease With Naltrexone And Dupilumab: A Report Of Two Cases., Breanna Santoso, Rachel Krevh, Alexa Israeli, Austin Cusick, Dawn Merritt, Michael Holsinger

Ambulatory and Primary Care Articles

This report presents two cases of patients with long-standing, treatment-resistant Hailey-Hailey disease (HHD) who experienced significant symptom relief through a combination therapy of oral naltrexone and dupilumab injections. The therapeutic potential of targeting the Th2 pathway and Ca

Incidence And Prevalence Of Hypertension In 18-40-Year-Old Patients Referred For Palpitations With Normal Cardiac Monitor Findings., Christopher Wasco, Zeryab Khan, Aimee Willett, Andrew Volio, Cody Carter, Aditya Kesari, Shaili Kothari, Andrew Scheidemantel, Katelyn Bennett, Jessalyn Schafer, Marie Lockhart, Nagesh Chopra

Ambulatory and Primary Care Articles

Sixteen percent of patients referred for cardiology evaluation are found to have no cause for palpitations. Studies show that hypertension intricately influences "heart rate" and "contractility,?" the key components of "palpitation." While the prevalence of hypertension is 22.4% in 18-39-year-olds, the relationship between palpitations and hypertension remains unknown in this age group. In our study, we assessed the incidence and prevalence of hypertension over 5 years in 18-40-year-olds referred for palpitations who had no known arrhythmic cause for palpitations between January 1, 206 and December 31, 2017. We found that over a period of 2.2 (0.7-4.1) years, an additional 56% …

Building Language Learning: Relations Between Infant Attention And Social Contingency In The First Year Of Life, Lillian R. Masek, Elizabeth V. Edgar, Brianna T.M. Mcmillan, James Torrence Todd, Roberta Michnick Golinkoff, Lorraine E. Bahrick, Kathy A. Hirsh-Pasek

Psychology: Faculty Publications

In Western societies, social contingency, or prompt and meaningful back-and-forth exchanges between infant and caregiver, is a powerful feature of the early language environment. Research suggests that infants with better attentional skills engage in more social contingency during interactions with adults and, in turn, social contingency supports infant attention. This reciprocity is theorized to build infant language skills as the adult capitalizes on and extends the infant’s attention during socially contingent interactions. Using data from 104 infants and caregivers, this paper tests reciprocal relations between infant attention and social contingency at 6- and 12-months and the implications for infant vocabulary …

Polygenic Liability For Anxiety In Association With Comorbid Anxiety In Multiple Sclerosis, Kaarina Kowalec, Arvid Harder, Casandra Dolovich, Kathryn C Fitzgerald, Amber Salter, Yi Lu, Charles N Bernstein, James M Bolton, Gary Cutter, John D Fisk, Joel Gelernter, Lesley A Graff, Sara Hägg, Carol A Hitchon, Daniel F Levey, Fred D Lublin, Kyla A Mckay, Scott Patten, Amit Patki, Murray B Stein, Hemant K Tiwari, Jerry S Wolinsky, Ruth A Marrie

Faculty, Staff and Student Publications

OBJECTIVE: Comorbid anxiety occurs often in MS and is associated with disability progression. Polygenic scores offer a possible means of anxiety risk prediction but often have not been validated outside the original discovery population. We aimed to investigate the association between the Generalized Anxiety Disorder 2-item scale polygenic score with anxiety in MS.

METHODS: Using a case-control design, participants from Canadian, UK Biobank, and United States cohorts were grouped into cases (MS/comorbid anxiety) or controls (MS/no anxiety, anxiety/no immune disease or healthy). We used multiple anxiety measures: current symptoms, lifetime interview-diagnosed, and lifetime self-report physician-diagnosed. The polygenic score was computed …

A Proposed Addition To The Modified Wells Criteria: Exploring Thrombosis In The E-World, Nidhin John, Amanda Kileen

School of Podiatric Medicine - Student Research

The advancement of technology and over-reliance on electronics have led to "e-thrombosis." This review investigates the link between prolonged sedentary behavior due to extensive electronic use and the risk of venous thromboembolism (VTE) and deep vein thrombosis (DVT). The term "e-thrombosis" was introduced in 2003 by Beasley et al., highlighting the risk of immobility associated with electronics. E-thrombosis is particularly relevant post-COVID-19, with increased remote working and online learning. This review evaluates recent studies to determine if e-thrombosis should be considered in updated screening tools like the Wells Score.

A systematic literature review was conducted using PubMed, Direct Science, and …

Protocol: Factors Influencing The Implementation Of Non-Pharmacological Interventions For Behaviours And Psychological Symptoms Of Dementia In Residential Aged Care Homes: A Systematic Review And Qualitative Evidence Synthesis, Hunduma D. Ayeno, Gizat M. M. Kassie, Mustafa Atee, Tuan Nguyen

Research outputs 2022 to 2026

This is a protocol for a Cochrane Review. The objectives are as follows. This paper aims to describe a protocol for a systematic review that will synthesise the qualitative evidence regarding factors influencing the implementation of non-pharmacological interventions (NPIs) for behavioural and psychological symptoms of dementia (BPSD) management in residential aged care homes (RACHs). The planned systematic review aims to answer the research question: ‘What are the factors influencing the implementation of NPIs in the management of BPSD at RACHs?’. Additionally, the planned systematic review also aims to generate recommendations to guide stakeholders (e.g., clinicians and aged care staff) and …

Cognitive And Neuroscientific Perspectives Of Healthy Ageing, Jon B. Prince, Helen L. Davis, Jane Tan, Katrina Muller-Townsend, Shaun Markovic, David M. G. Lewis, Brianne Hastie, Matthew B. Thompson, Peter D. Drummond, Hakuei Fujiyama, Hamid R. Sohrabi

Research outputs 2022 to 2026

With dementia incidence projected to escalate significantly within the next 25 years, the United Nations declared 2021–2030 the Decade of Healthy Ageing, emphasising cognition as a crucial element. As a leading discipline in cognition and ageing research, psychology is well-equipped to offer insights for translational research, clinical practice, and policy-making. In this comprehensive review, we discuss the current state of knowledge on age-related changes in cognition and psychological health. We discuss cognitive changes during ageing, including (a) heterogeneity in the rate, trajectory, and characteristics of decline experienced by older adults, (b) the role of cognitive reserve in age-related cognitive decline, …

Factors Impacting Nursing Assistants To Accept A Delegation In The Acute Care Settings: A Mixed Method Study, Carol Crevacore, Linda Coventry, Christine Duffield, Elisabeth Jacob

Research outputs 2022 to 2026

Aims: To investigate the experience of nursing assistants being delegated nursing tasks by registered nurses. Design: Mixed method explanatory sequential design. Methods: A total of 79 nursing assistants working in an acute hospital in Australia completed surveys that aimed to identify their experience of working with nurses and the activities they were delegated. The survey data were analysed using descriptive statistics. Interviews with 11 nursing assistants were conducted and analysed using Braun and Clarke's thematic analysis. Results were triangulated to provide a richer understanding of the phenomena. Results: Most nursing assistants felt supported completing delegated care activities. However, there was …

Before You Stick, Know The Tricks!, Quinlan Duncan, Samantha Entwisle, Destiny Nwoko, Ashley Rich

2023

No abstract provided.

Prevention Is The Only Way, Don't Let A Fall Ruin Your Day, Grace Wichmann, Sagen Williams, Deanna Fleeman, Lauren Kinner, Caroline Honza

2023

No abstract provided.

Effects Of Weighted Blanket Use On Comfort Levels In The Inpatient Pediatric Population, Madelym Talbert, Kristen Bowen, Bianca Maughmer, Gisselle Garza, Alyssa Carrizales, Graciela Gutierrez, Halle Kliemann, Katelyn Dickerson

2023

No abstract provided.

The Effectiveness Of Photo-Biomodulation Therapy In Oral Mucositis, Molly Amado, Kara Otts, Madeline Scott, Sophie Steffey, Katie Williams, Evelyn Zaragoza

2023

No abstract provided.

Bundle Up For Ue Prevention, Mikaela Potaracke, Bre Showers, Nia Traylor, Duy Lu

2023

No abstract provided.

Evaluating Nurse Perception Of Continuous Glucometer Monitoring (Cgm) Use At The Bedside, Valeria De La Torre, Shantia Henderson, Savannah Kenvin, Hannah Lee, Faith Van Haaster, Jordan White

2023

No abstract provided.

Ready, Set, Code!Investigating The Use Of Two Standardized Resuscitation Algorithms To Improve Outcomes In Patients In A Level 4 Nicu., Lauren Ayala, Grace Farina, Shelby Hudson, Anna Nguyen, Mireya Ortiz, Luke Wuesthoff

2023

No abstract provided.

Rn Perception Of Ease During Pediatric Capillary Blood Draws, Cierra Davis, Rachel Santinover, Maria Soria, Amber Waldron, Tarayja White

2023

No abstract provided.

Improving Communication With Patient Passports, Terrie-Lynne Hundley, Alexandra Schreiber, Tiffany Dang, Breezy Escamilla Herrera, Samantha Le, Elizabeth Vincent, Surabhi Lamsal, Bianca Hernandez, Andrea Robinson

2023

No abstract provided.

Voices Of Experience: Lay Perspectives On Severe Maternal Morbidity In Appalachia, Anna Hansen, Cassidy Carter, Nancy Schoenberg, Carrie B. Oser

UK CARES Faculty Publications

No abstract provided.

Targeting Trpc3: A Promising Therapeutic Strategy For Alzheimer's Disease, Jiaxing Wang

Alternative Theses and Dissertations (AETDs)

Alzheimer's disease (AD) is a progressive neurological disorder characterized by extracellular β-amyloid (Aβ) plaques and intracellular tau tangles. The calcium (Ca2+) hypothesis of AD proposes that disrupted intracellular Ca2+ regulation underlies AD pathology, contributing to inflammation, oxidative stress, impaired autophagy, neurodegeneration, and cognitive dysfunction. Store-operated Ca2+ entry (SOCE) maintains ER Ca2+ stores, involving transient receptor potential canonical (TRPC) and Orai channels. Specifically, we speculated that dysregulated functions of TRPC3 contribute to the pathogenesis of AD. We believe that targeting TRPC3 with a pharmacologically feasible agent could prove beneficial in halting cognitive decline. We previously reported compound JW-65, a novel, metabolically …

Nutritional Supplementation In Children With Severe Pneumonia In Uganda And Kenya (Coast-Nutrition): A Phase 2 Randomised Controlled Trial, Sarah Kiguli, Peter Olupot-Olupot, Mainga Hamaluba, Elisa Giallongo, Karen Thomas, Florence Alaroker, Robert Opoka, Abner Tagoola, Shela Oyella, Damalie Nalwanga

Paediatrics and Child Health, East Africa

Background Severe pneumonia in African children results in poor long-term outcomes (deaths/readmissions) with undernutrition as a key risk factor. We hypothesised additional energy/protein-rich Ready-to-Use Therapeutic Foods (RUTF) would meet additional nutritional requirements and improve outcomes.

Methods COAST-Nutrition was an open-label Phase 2 randomised controlled trial in children (aged 6 months-12 years) hospitalised with severe pneumonia (and hypoxaemia, SpO2 <92%) in Mbale, Soroti, Jinja, Masaka Regional Referral Hospitals, Uganda and Kilifi County Hospital, Kenya (ISRCTN10829073 (registered 6th June 2018) PACTR202106635355751 (registered 2nd June 2021)). Children were randomised (ratio 1:1) to enhanced nutritional supplementation with RUTF (plus usual diet) for 56 days vs usual diet (control). The primary outcome was change in mid-upper arm circumference (MUAC) at 90 days as a composite with mortality. Secondary outcomes include anthropometric status, mortality, and readmissions at Days 28, 90 and 180.

Findings Between 12 August 2018 and 22 April 2022, 846 eligible children were randomised, 424 to RUTF and 422 to usual diet, and followed for 180-days [12 (1%) lost-to-follow-up]. RUTF supplement was initiated in 417/419 (>99%). By Day 90, there was …

International Consensus On Standard Outcome Measures For Neurodevelopmental Disorders: A Consensus Statement, Melissa Mulraney, Umanga De Silva, Andria Joseph, Maria Da Luz Sousa Fialho, Iain Dutia, Natalie Munro, Jonathan M. Payne, Tobias Banaschewski, Cláudia Bandeira De Lima, Susan Wamithi

Paediatrics and Child Health, East Africa

Importance: The use of evidence-based standardized outcome measures is increasingly recognized as key to guiding clinical decision-making in mental health. Implementation of these measures into clinical practice has been hampered by lack of clarity on what to measure and how to do this in a reliable and standardized way.

Objective: To develop a core set of outcome measures for specific neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD), communication disorders, specific learning disorders, and motor disorders, that may be used across a range of geographic and cultural settings.

Evidence Review: An international working group composed of clinical and research experts …

Radiogenomics-Based Risk Prediction Of Glioblastoma Multiforme With Clinical Relevance, Xiaohua Qian, Hua Tan, Xiaona Liu, Weiling Zhao, Michael D Chan, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Glioblastoma multiforme (GBM)is the most common and aggressive primary brain tumor. Although temozolomide (TMZ)-based radiochemotherapy improves overall GBM patients' survival, it also increases the frequency of false positive post-treatment magnetic resonance imaging (MRI) assessments for tumor progression. Pseudo-progression (PsP) is a treatment-related reaction with an increased contrast-enhancing lesion size at the tumor site or resection margins miming tumor recurrence on MRI. The accurate and reliable prognostication of GBM progression is urgently needed in the clinical management of GBM patients. Clinical data analysis indicates that the patients with PsP had superior overall and progression-free survival rates. In this study, we aimed …

Impact Of Prenatal Maternal Depression On Gestational Length Post Hoc Analysis Of A Randomized Clinical Trial, Elysia Poggi Davis, Catherine H. Demers, Lillybelle Deer, Robert Gallop, M. Camille Hoffman, Nancy Grote, Benjamin L. Hankin

Mathematics Faculty Publications

Background Shortened gestation is a leading cause of childhood morbidity and mortality with lifelong consequences for health. There is a need for public health initiatives on increasing gestational age at birth. Prenatal maternal depression is a pervasive health problem robustly linked via correlational and epidemiological studies to shortened gestational length. This proof-of-concept study tests the impact of reducing prenatal maternal depression on gestational length with analysis of a randomized clinical trial (RCT).

Methods Participants included 226 pregnant individuals enrolled into an RCT and assigned to receive either interpersonal psychotherapy (IPT) or enhanced usual care (EUC). Recruitment began in July 2017 …