Medicine and Health Sciences Commons^™

Exploring Associations Between Poverty, Race/Ethnicity, Gender, And Childhood Obesity In Cherokee County, South Carolina, Lillie Mae Hall

Walden Dissertations and Doctoral Studies

Childhood obesity (CHO) rates have increased significantly worldwide over the last decade. The magnitude of CHO extends beyond physical health to include economic stability, social connections, and access to daily living resources. CHO is complex and requires a multifaceted approach that may differ from traditional prevention approaches and treatment. Over the years, interventions have focused on maintaining a balance of healthy eating and active living to reduce weight and promote lifelong behavior change. Body mass index (BMI) surveillance studies have been conducted in Cherokee County, South Carolina since 2012 to assess and inform CHO interventions. However, the data have not …

Excess Prevalence Of Preexisting Chronic Conditions In Older Adults With Incident Epilepsy, Siran M. Koroukian, Hannah L. Fein, Long Vu, Wyatt P. Bensken, Nicholas K. Schiltz, Martha Sajatovic

Faculty Scholarship

Objective: Prior studies have examined chronic conditions in older adults with prevalent epilepsy, but rarely among those with incident epilepsy. Identifying the chronic conditions with which older adults present at epilepsy incidence assists with the evaluation of disease burden in this patient population and informs coordinated care development. The aim of this study was to identify preexisting chronic conditions with excess prevalence in older adults with incident epilepsy compared to those without. Methods: Using a random sample of 4 999 999 fee-for-service Medicare beneficiaries aged >65 years, we conducted a retrospective cohort study of epilepsy incidence in 2019. Non-Hispanic Black …

Understanding The Relationship Between [Atp], Growth Rate, And Inoculum Effect In Β-Lactamase Producing Bacteria, Ariane R. Kalifa

All HCAS Student Capstones, Theses, and Dissertations

2.8 million Americans are infected with antibiotic-resistant bacteria on an annual basis, leading to increased mortality and morbidity. With the incidence of infection due to antibiotic-resistant bacteria on the rise, it is critical to understand the mechanisms bacteria use to resist antibiotics. The inoculum effect (IE) is a phenomenon that has been observed for many antibiotics and bacterial species. In IE, the density of the bacterial population determines the minimum inhibitory concentration of the antibiotic (MIC) of an antibiotic; as the density of the bacterial population increases, the MIC increases. IE is highly prevalent in bacteria that express β-lactamases where …

Perception Of Pre-Existing Dm2 Management Among Pregnant Asian Indian Immigrants During Covid-19, Sanya Bedi Grewal

Walden Dissertations and Doctoral Studies

Type 2 diabetes is a chronic disease that exerts a significant burden among communities by increasing healthcare costs, reducing productivity, higher rates for premature mortality, and tangible socioeconomic burden, which overall reduces the quality of life. The purpose of the study was to explore the perception of pregnant Asian Indian immigrants regarding diabetes self-management strategies during the COVID-19 pandemic. Five women were recruited via purposive sampling from Facebook groups. Data were collected via individual interviews using Facebook groups. The health belief model was used to help understand and interpret the findings. Clarke and Braun’s thematic analysis method was used to …

Impact Of Telehealth On Type 2 Diabetes Self-Management During The Covid-19 Pandemic, Nancy Olivo Marshall

Walden Dissertations and Doctoral Studies

The incidence of Type 2 diabetes mellitus (T2DM) is on the rise, particularly among adults aged 18 years and older. Glycosylated hemoglobin (HbA1c) levels are commonly used by healthcare professionals to assess glucose variability; fluctuations are associated with an increased risk of adverse effects. The COVID-19 pandemic highlighted the importance of self-directed management of HbA1c levels through telehealth. The purpose of this retrospective quantitative study was to investigate the effectiveness of self-directed management of HbA1c levels using telehealth among T2DM diagnosed adults at a community health service organization in the northeastern U.S. from December 2018 to 2022. Using multivariate regression …

Exploring Associations Between Poverty, Race/Ethnicity, Gender, And Childhood Obesity In Cherokee County, South Carolina, Lillie Mae Hall

Walden Dissertations and Doctoral Studies

Childhood obesity (CHO) rates have increased significantly worldwide over the last decade. The magnitude of CHO extends beyond physical health to include economic stability, social connections, and access to daily living resources. CHO is complex and requires a multifaceted approach that may differ from traditional prevention approaches and treatment. Over the years, interventions have focused on maintaining a balance of healthy eating and active living to reduce weight and promote lifelong behavior change. Body mass index (BMI) surveillance studies have been conducted in Cherokee County, South Carolina since 2012 to assess and inform CHO interventions. However, the data have not …

Phytochemical Screening, Antioxidant Activity, And Cytotoxicity Of Ethanol, Ethyl Acetate, And N-Hexane Kluwak (Pangium Edule) Extract On Mcf-7 Breast Cancer Cells, Raniindra Khalisha Soediro Abidin, Ade Arsianti

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Breast cancer occurs quite high and is one of the main causes of death in Indonesia and the world. Current treatment for cancer is expensive and has varying degrees of success and can cause side effects for patients. Kluwak (Pangium edule), whose reseach is still limited has the potential to be used as an alternative treatment for breast cancer. Methods: Kluwak powder was macerated using three different types of solvents to obtain ethanol extract, ethyl acetate extract and n-hexane kluwak extract. Phytochemical tests and thin layer chromatography (TLC) were carried out to determine the type and amount …

Piga Mutations And Glycosylphosphatidylinositol Anchor Dysregulation In Polyposis-Associated Duodenal Tumorigenesis, Elena Meuser, Kyle Chang, Angharad Walters, Joanna J Hurley, Hannah D West, Iain Perry, Matthew Mort, Laura Reyes-Uribe, Rebekah Truscott, Nicholas Jones, Rachel Lawrence, Gareth Jenkins, Peter Giles, Sunil Dolwani, Bilal Al-Sarireh, Neil Hawkes, Emma Short, Geraint T Williams, Melissa W Taggart, Kim Luetchford, Patrick M Lynch, Diantha Terlouw, Maartje Nielsen, Sarah-Jane Walton, Andrew Latchford, Susan K Clark, Julian R Sampson, Eduardo Vilar, Laura E Thomas

Faculty, Staff and Student Publications

The pathogenesis of duodenal tumors in the inherited tumor syndromes familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) is poorly understood. This study aimed to identify genes that are significantly mutated in these tumors and to explore the effects of these mutations. Whole exome and whole transcriptome sequencing identified recurrent somatic coding variants of phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA) in 19/70 (27%) FAP and MAP duodenal adenomas, and further confirmed the established driver roles for APC and KRAS. PIGA catalyzes the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. Flow cytometry of PIGA-mutant adenoma-derived and CRISPR-edited duodenal organoids confirmed loss of …

Postoperative Bioactive Adrenomedullin Is Associated With The Onset Of Ards And Adverse Outcomes In Patients Undergoing Open Thoracoabdominal Aortic Surgery, Panagiotis Doukas, Oliver Hartmann, Jelle Frankort, Birte Arlt, Hanif Krabbe, Michael Johan Jacobs, Andreas Greiner, Jan Paul Frese, Alexander Gombert

Faculty, Staff and Student Publications

Cytokine-mediated systemic inflammation after open thoracoabdominal aortic aneurysm (TAAA) repairs plays a pivotal role in disrupting circulatory homeostasis, potentially leading to organ dysfunction. The bioactive form of adrenomedullin (bio-ADM) is a peptide hormone with immunomodulatory and vasomotor effects, making it a potential diagnostic agent in these cases. This retrospective, bicentric study, conducted between January 2019 and December 2022, recruited 36 elective open TAAA repair patients in two German centres. Serum and plasma samples were collected at multiple time points to measure bio-ADM levels. The primary objective was to evaluate the association of bio-ADM levels with the onset of acute respiratory …

Orthogonal Proteogenomic Analysis Identifies The Druggable Pa2g4-Myc Axis In 3q26 Aml, Matteo Marchesini, Andrea Gherli, Elisa Simoncini, Lucas Moron Dalla Tor, Anna Montanaro, Natthakan Thongon, Federica Vento, Chiara Liverani, Elisa Cerretani, Anna D'Antuono, Luca Pagliaro, Raffaella Zamponi, Chiara Spadazzi, Elena Follini, Benedetta Cambò, Mariateresa Giaimo, Angela Falco, Gabriella Sammarelli, Giannalisa Todaro, Sabrina Bonomini, Valentina Adami, Silvano Piazza, Claudia Corbo, Bruno Lorusso, Federica Mezzasoma, Costanza Anna Maria Lagrasta, Maria Paola Martelli, Roberta La Starza, Antonio Cuneo, Franco Aversa, Cristina Mecucci, Federico Quaini, Simona Colla, Giovanni Roti

Faculty, Staff and Student Publications

The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 abnormalities. By taking advantage of the intersectionality of high-throughput cell-based and gene expression screens selective and pan-histone deacetylase inhibitors (HDACis) emerge as potent repressors of EVI1. To understand the mechanism driving on-target anti-leukemia activity of this compound class, here we dissect the expression dynamics of the bone marrow leukemia cells of patients treated with HDACi and reconstitute the EVI1 chromatin-associated co-transcriptional complex merging on the role of proliferation-associated 2G4 (PA2G4) protein. PA2G4 overexpression rescues AML cells from the …

Teen Pregnancy Involvement Among African, Caribbean And Black Adolescent Boys And Girls: A Scoping Review Protocol, Emmanuela Ojukwu, Eunice Bawafaa, Emily Mckay, Harsimran Grewal, Sara Afsah, Shivangi Singh, Elizabeth Saewyc

Faculty, Staff and Student Publications

OBJECTIVES: This study aims to investigate the incidence, associated factors and interventions to address teen pregnancy involvement (TPI) among African, Caribbean and Black (ACB) adolescents in North America.

DESIGN: We conducted a scoping review of the literature, guided by the social-ecological model.

DATA SOURCES: Studies were retrieved from databases such as Ovid Medline, Ovid Embase, CINAHL, CAB Direct and Google Scholar and imported into COVIDENCE for screening.

ELIGIBILITY CRITERIA: The Joanna Briggs Institute scoping reviews protocol guided the establishment of eligibility criteria. Included studies focused on rates, associated factors and interventions related to TPI among ACB boys and girls aged …

Perception Of Pre-Existing Dm2 Management Among Pregnant Asian Indian Immigrants During Covid-19, Sanya Bedi Grewal

Walden Dissertations and Doctoral Studies

Type 2 diabetes is a chronic disease that exerts a significant burden among communities by increasing healthcare costs, reducing productivity, higher rates for premature mortality, and tangible socioeconomic burden, which overall reduces the quality of life. The purpose of the study was to explore the perception of pregnant Asian Indian immigrants regarding diabetes self-management strategies during the COVID-19 pandemic. Five women were recruited via purposive sampling from Facebook groups. Data were collected via individual interviews using Facebook groups. The health belief model was used to help understand and interpret the findings. Clarke and Braun’s thematic analysis method was used to …

Access To Prostate-Specific Antigen Testing And Mortality Among Men With Prostate Cancer, Hari S. Iyer, Benjamin V. Stone, Charlotte Roscoe, Mei Chin Hsieh, Antoinette M. Stroup, Charles L. Wiggins, Fredrick R. Schumacher, Scarlett L. Gomez, Timothy R. Rebbeck, Quoc Dien Trinh

School of Public Health Faculty Publications

Importance: Prostate-specific antigen (PSA) screening for prostate cancer is controversial but may be associated with benefit for certain high-risk groups. Objectives: To evaluate associations of county-level PSA screening prevalence with prostate cancer outcomes, as well as variation by sociodemographic and clinical factors. Design, Setting, and Participants: This cohort study used data from cancer registries based in 8 US states on Hispanic, non-Hispanic Black, and non-Hispanic White men aged 40 to 99 years who received a diagnosis of prostate cancer between January 1, 2000, and December 31, 2015. Participants were followed up until death or censored after 10 years or December …

Hairy Tongue Associated With The Use Of Baricitinib Therapy For Ophiasis Pattern Alopecia Areata, Anthony Gaspari

Department of Dermatology and Cutaneous Biology Faculty Papers

We report a case of hairy tongue that developed in a young Caucasian
/="/">woman during systemic baricitinib therapy for severe alopecia areata.
/="/">Because she experienced good clinical regrowth of her hair during
/="/">treatment, she did not want to interrupt therapy. We recommended she
/="/">use a toothbrush to debride her tongue on a daily basis, which was
/="/">successful. Hairy tongue most commonly occurs in elderly, debilitated
/="/">males with poor oral hygiene. It is thought to occur because of overgrowth
/="/">of chromogenic bacteria and/or yeast on the tongue. This unusual side
/="/">effect during baricitinib …

Enhancing Post-Traumatic Stress Disorder Patient Assessment: Leveraging Natural Language Processing For Research Of Domain Criteria Identification Using Electronic Medical Records, Oshin Miranda, Sophie Marie Kiehl, Xiguang Qi, M Daniel Brannock, Thomas Kosten, Neal David Ryan, Levent Kirisci, Yanshan Wang, Lirong Wang

Faculty, Staff and Students Publications

Background: Extracting research of domain criteria (RDoC) from high-risk populations like those with post-traumatic stress disorder (PTSD) is crucial for positive mental health improvements and policy enhancements. The intricacies of collecting, integrating, and effectively leveraging clinical notes for this purpose introduce complexities.

Methods: In our study, we created a natural language processing (NLP) workflow to analyze electronic medical record (EMR) data and identify and extract research of domain criteria using a pre-trained transformer-based natural language model, all-mpnet-base-v2. We subsequently built dictionaries from 100,000 clinical notes and analyzed 5.67 million clinical notes from 38,807 PTSD patients from the University of Pittsburgh …

Strategies For Chronic Coronary Disease: A Brief Guide For Clinicians, Chayakrit Krittanawong, Muzamil Khawaja, Hafeez Ul Hassan Virk, Johao Escobar, Umair Khalid, Yochai Birnbaum, Carl J Lavie, Samin Sharma, Hani Jneid, Sunil Rao, Salim S Virani

Faculty, Staff and Students Publications

The 2023 Multisociety Guidelines for the Management of Patients with Chronic Coronary Disease (CCD) is a collaborative effort between the American Heart Association (AHA) and the American College of Cardiology (ACC) that provides recommendations on the management of this condition. Efficient management of CCD involves non-pharmaceutical interventions that promote healthier lifestyles, such as increasing physical activity, adopting a balanced diet, and addressing tobacco misuse. These changes are critical to improving cardiovascular outcomes for individuals with CCD. In addition to lifestyle modifications, pharmacological and revascularization treatments also play an essential role in managing CCD. These treatments target the complex mechanisms of …

Comparison Of Different Pinning Techniques For 3d-Printed Radius With Salter-Harris Type I Fracture, Tea-Hyung Kim, Hwi-Yool Kim

The Thai Journal of Veterinary Medicine

The purpose of the present study was to compare different pinning techniques for distal radius with Salter-Harris type I fracture. Computed Tomography (CT) images of a distal antebrachium of the 6.5 kg, growing, 6-month-old intact male mongrel dog were 3D-printed with Polycarbonate (PC) material. Twenty-one synthetic bones were classified into three groups. Cross pinning, Parallel pinning, and HK2 pinning techniques were applied to each group. A compressive shear test was applied to each group, and the results at 1 mm, 2 mm, and 3 mm displacement and the load at failure were analyzed through statistical software. It was found that …

How To Take A Proactive Approach To Reduce Cancellations & No-Shows, Carrie Webber

Metro Denver Dental Society Articulator Magazine

Cancellations and no-shows wreak havoc on dental practice schedules, with 80% of practices citing last-minute cancellations as the main reason for incomplete schedules. This article provides a proactive approach to minimize cancellations by focusing on three key areas: enhancing the patient experience to build trust and perceived value, optimizing the check-out process with effective communication, and providing ongoing team training on verbal skills and customer service. By implementing strategies that prioritize patient relationships, commitment, and a seamless experience, practices can reduce cancellations, improve scheduling efficiency, and foster patient loyalty.

Practicing Dentistry: The Most Dangerous Profession?, Stephanie Botts Rdh, Bsdh, Ceas

Metro Denver Dental Society Articulator Magazine

Musculoskeletal disorders (MSDs) are highly prevalent among dental clinicians due to repetitive movements, awkward postures, and static positions. This article highlights the importance of ergonomics - designing work environments for the worker - in preventing career-threatening MSDs. Key principles discussed include proper operator positioning establishing neutral spinal alignment, adjusting patient positioning to minimize harmful movements, and adopting an "ergonomic mindset" prioritizing clinicians' musculoskeletal health. The article discusses how through comprehensive ergonomic interventions, dental professionals can reduce injury risks and enjoy long, pain-free careers.

Shift Your Energy To Shift Your Burnout, Laura Brenner Dds

Metro Denver Dental Society Articulator Magazine

This article explores why standard burnout treatments like self-care activities and practice ownership often provide temporary relief but fail to address the root cause. The author identifies a common pattern among burnt-out, "Compassionate Caretakers" - a tendency towards people-pleasing, perfectionism, and self-sacrifice driven by a need for validation. In contrast, those who avoid burnout ("Solution Seekers") maintain healthy boundaries, let go of others' problems, and operate from a mindset of win-win solutions. By reframing perspectives through self-awareness and allowing self-compassion, Compassionate Caretakers can shift to become Solution Seekers. This inner work provides the energy to genuinely address external burnout triggers …

Self-Care For Healthcare Professionals, Purnima Hernandez Dda, Ms, Ma, Chwc

Metro Denver Dental Society Articulator Magazine

This personal narrative chronicles the author's journey to prioritize self-care and adopt a lifestyle medicine approach after experiencing unexplained at the peak of her career. Realizing that succeeding in a profession dedicated to helping others required first helping herself, she immersed herself in learning about diet and lifestyle changes. By making reasonable adjustments to her sleep, nutrition, stress management, movement, and relationships, her health drastically improved within months. The article emphasizes the importance of self-care for healthcare professionals to avoid burnout and chronic lifestyle diseases. It provides a framework for developing a personalized lifestyle plan. Ultimately, the piece is a …

How To Get Started With Sotl: Reflections From A Novice Sotl Researcher, Janine L. Schmedding-Bartley

Teaching and Learning in Communication Sciences & Disorders

The purpose of this paper is to provide a reflection on successfully engaging in the scholarship of teaching and learning (SoTL) after overcoming common barriers to engagement in SoTL. The author identifies barriers commonly experienced by scholars interested in engaging in SoTL. The author identified a variety of frameworks in the literature that were reported to be helpful in assisting novice SoTL scholars in overcoming barriers related to research question formation. An example is shared to demonstrate how the complementary frameworks can be used to develop answerable research questions.

Finding My Path: Transitioning From Clinician To Professor, Jordan Tinsley

Teaching and Learning in Communication Sciences & Disorders

This manuscript is a reflection on the author’s transition from practicing as a clinical speech-language pathologist (SLP) to entering the academic arena as a clinical assistant professor. The author considers various steps that may be supportive of the transition from clinical practice to academia for SLPs without a research degree (i.e., Ph.D.). Lessons learned throughout the job transition process are shared to illuminate the path for SLPs who are curious entering a university setting. Additionally, the author’s experience in the TLCSD SoTL Fellows Program is discussed.

Qualitative Inquiry: The Case For The Importance Of Considering Student Perspectives In Sotl Research, Aleah S. Brock

Teaching and Learning in Communication Sciences & Disorders

Quantitative methods are often viewed as superior to qualitative methods for clinical research in communication sciences and disorders; however, quantitative methods are unable to answer questions of why or how. Qualitative methodology can be used to address research questions that seek to understand human perspectives. In Scholarship of Teaching and Learning (SoTL) research, qualitative research can be used to understand student experiences and perspectives. The merit of the application of qualitative methodology in SoTL research is explored here.

Speech-Language Pathology Graduate Students’ Experiences With The Use Of Case-Based Learning To Develop Skills For Evidence-Based Practice, Aleah S. Brock

Teaching and Learning in Communication Sciences & Disorders

The American Speech-Language Hearing Association (ASHA) states that practitioners should use the principles of evidence-based practice (EBP) for clinical decision making. However, speech-language pathologists (SLPs) often report a lack of understanding, time, and resources to implement EBP. Clinicians who were exposed to EBP training during their graduate program or clinical fellowship are more likely to use EBP in their clinical practice; therefore, graduate programs in SLP must provide explicit EBP training to upcoming clinicians. At present, no consensus exists on the best way to train students in the principles of EBP. The present study sought to investigate student experiences and …

Establishing A Scholarship Of Teaching And Learning Fellows Program, Jennifer Friberg, Mark Deruiter

Teaching and Learning in Communication Sciences & Disorders

Teaching and Learning in Communication Sciences and Disorders established a scholarship of teaching and learning (SoTL) Fellows program in 2022. The SoTL Fellows program engaged with five different mentored projects over the course of one year. Fellows were invited to submit manuscripts regarding their reflections on SoTL, as well as their original research, for this issue of TLCSD.

Physical Therapy Graduate Perceptions Of The Didactic Use Of Goreact Video Assessment Software And Work Readiness, Jacqueline Moore

Journal of Innovation in Health Sciences Education

Introduction: Physical therapy education programs adopting online teaching and learning must ensure students acquire the necessary skills for optimal professional work readiness, including appropriate assessment and feedback in the online environment. The purpose of this qualitative study was to explore the perceptions of Doctor of Physical Therapy (DPT) graduates' professional work readiness after using GoReact video assessment software at an accredited DPT education program in the United States.

Methods: Semi structured interviews were conducted with 15 DPT graduates via virtual teleconferencing software. Interview data were analyzed using descriptive and emotion coding.

Results: Results indicated that most participants held an …

Medmicromaps, A Novel Decision-Tree Guide For Infectious Diseases Differential Diagnoses, And Evaluation Of Pre- And Post-Pandemic User Engagement By Preclinical Medical Students, Jason Ceballos, Tavsimran Luthra, Lucia Garces-Torres, Valerie Lentz, Jack Nelson, Claudia Carceles-Roman, Ian Holyoak, Jane Harrington

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

Background: Medical education has undergone major changes in the past 5 years to adapt to the digital-centered student population with diverse learning preferences. To address the challenges of shifting delivery modalities, multimedia resources were created to provide interactive e-learning material on infectious diseases for year 2 medical students.

Methods: Medical students at a USA-accredited Caribbean medical school were provided with supplemental e-learning materials including animations, illustrations, diagnostic algorithms aka MedMicroMaps, and Case-Based tutorials. Participants were classified by semester and lecture delivery: In-person: Cohort 1 (n=526); Virtual: Cohort 2 (n=651); and Hybrid: Cohort 3 ( …

Factors Predicting The Intention To Engage In Self-Protective Behavior Against Monkeypox Infection Among Thai People, Awirut Singkun, Wichan Phibarn, Wichaporn Intharachuti, Arunothai Derramon, Thitika Kimise

Journal of Health Research

Background: An emerging monkeypox outbreak in many countries caused the WHO to declare the disease an international public health problem. This study aimed to explore knowledge of monkeypox and its transmission, intention to engage in self-protection, and factors predicting the intention to engage in self-protective behavior among Thai people.

Methods: A cross-sectional design was conducted between September and October 2022 with a self-administered questionnaire through an online survey. A total of 581 respondents were included in the data analysis. Descriptive statistics, and a binary logistic regression were used.

Results: Most respondents had good knowledge of monkeypox and its transmission …

A “Fishy” Situation, Rare Pathogen And Presentation In Prosthetic Valve Infective Endocarditis, Nichole Schtupak, Patrick Kennedy, Darko Pucar, Linda Godinez, Jodi-Ann Chin, Kristen Selema, Dipan Uppa, Antonio Lewis, Marcelo Helguera

DMSc Student Publications

Lactococcus garviae (L. garviae) is a gram-positive coccus belonging to the Streptococcaceae family. While primarily a pathogen in fish farms causing hemorrhagic sepsis, it can act as a rare opportunistic pathogen in humans. A 2021 case report by Bravo et al. documented less than 30 cases of infective endocarditis caused by L. garviae worldwide at that time. This case report describes the 27th documented case globally and 7th documented case in the USA of L. garviae causing infective endocarditis of a prosthetic valve.
L. garviae is found in unpasteurized dairy products, raw fish, and meat (pork, beef, and …