Medicine and Health Sciences Commons^™

An Exploratory Analysis Of Sociodemographic Factors Associated With Physical Functional Impairment In Icu Survivors, Megan A. Watson, Marie Sandi, Johanna Bixby, Grace Perry, Patrick J. Offner, Ellen L. Burnham, Sarah E. Jolley

School of Medicine Faculty Publications

IMPORTANCE: Physical functional impairment is one of three components of postintensive care syndrome (PICS) that affects up to 60% of ICU survivors. OBJECTIVES: To explore the prevalence of objective physical functional impairment among a diverse cohort of ICU survivors, both at discharge and longitudinally, and to highlight sociodemographic factors that might be associated with the presence of objective physical functional impairment. DESIGN, SETTING, AND PARTICIPANTS: This was a secondary analysis of 37 patients admitted to the ICU in New Orleans, Louisiana, and Denver, Colorado between 2016 and 2019 who survived with longitudinal follow-up data. MAIN OUTCOMES AND MEASURES: Our primary …

Blocking Oncostatin M Receptor Abrogates Stat3 Mediated Integrin Signaling And Overcomes Chemoresistance In Ovarian Cancer, Anjali Geethadevi, Zhiqiang Ku, Shirng-Wern Tsaih, Deepak Parashar, Ishaque P Kadamberi, Wei Xiong, Hui Deng, Jasmine George, Sudhir Kumar, Sonam Mittal, Ningyan Zhang, Sunila Pradeep, Zhiqiang An, Pradeep Chaluvally-Raghavan

The Brown Foundation: Institute of Molecular Medicine

Chemotherapy such as cisplatin is widely used to treat ovarian cancer either before or after surgical debulking. However, cancer relapse due to chemotherapy resistance is a major challenge in the treatment of ovarian cancer. The underlying mechanisms related to chemotherapy resistance remain largely unclear. Therefore, identification of effective therapeutic strategies is urgently needed to overcome therapy resistance. Transcriptome-based analysis, in vitro studies and functional assays identified that cisplatin-resistant ovarian cancer cells express high levels of OSMR compared to cisplatin sensitive cells. Furthermore, OSMR expression associated with a module of integrin family genes and predominantly linked with integrin αV (ITGAV) and …

Hemoglobin A1c Values In Patients With Two Types Of Insurance, Patricia Ann White

Walden Dissertations and Doctoral Studies

Diabetes is the seventh leading cause of death for adults in the United States. Evidence suggests that not all patients receive the same level of care and discrepancies may be based on the type of health care coverage they have. Providers use Hemoglobin A1C (A1C) as the primary test to indicate treatment success for persons with diabetes. Providers may be ordering this critical lab value differently based on the patient’s insurance plan. In this project, A1C levels in diabetic patients receiving managed care versus traditional Medicare were evaluated. It is important to understand if potential disparities in care exist. The …

Quality Of Life Factors In Children With Dual Diagnosis Stuttering And Autism Spectrum Disorder, Kristen N. Rollins

USF Tampa Graduate Theses and Dissertations

Addressing quality of life is a critical part of speech-language pathology. Understanding quality of life deficits and challenges in our patients’ lives allows us to provide well-rounded treatment. Quality of life in children who stutter and children with autism spectrum disorder has been heavily researched (children with autism spectrum disorder to a lesser extent). However, despite approximately 1 in 1000 children being dually diagnosed with stuttering and autism spectrum disorder (Briley & Ellis, 2018), quality of life in this population has never been researched. This thesis aims to determine whether children diagnosed with both conditions experience similar quality of life …

Clinical Practice Guidelines For The Care Of Girls And Women With Turner Syndrome, Claus H Gravholt, Niels H Andersen, Sophie Christin-Maitre, Shanlee M Davis, Anthonie Duijnhouwer, Aneta Gawlik, Andrea T Maciel-Guerra, Iris Gutmark-Little, Kathrin Fleischer, David Hong, Karen O Klein, Siddharth K Prakash, Roopa Kanakatti Shankar, David E Sandberg, Theo C J Sas, Anne Skakkebæk, Kirstine Stochholm, Janielle A Van Der Velden, International Turner Syndrome Consensus Group, Philippe F Backeljauw

Faculty, Staff and Student Publications

Turner syndrome (TS) affects 50 per 100 000 females. TS affects multiple organs through all stages of life, necessitating multidisciplinary care. This guideline extends previous ones and includes important new advances, within diagnostics and genetics, estrogen treatment, fertility, co-morbidities, and neurocognition and neuropsychology. Exploratory meetings were held in 2021 in Europe and United States culminating with a consensus meeting in Aarhus, Denmark in June 2023. Prior to this, eight groups addressed important areas in TS care: (1) diagnosis and genetics, (2) growth, (3) puberty and estrogen treatment, (4) cardiovascular health, (5) transition, (6) fertility assessment, monitoring, and counselling, (7) health …

Quantitative Proteomic Analysis Reveals Unique Hsp90 Cycle-Dependent Client Interactions, Erick I Rios, Davi Gonçalves, Kevin A Morano, Jill L Johnson

Faculty, Staff and Student Publications

Hsp90 is an abundant and essential molecular chaperone that mediates the folding and activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or indirectly impacts the function of 10-15% of all proteins due to degradation of client proteins or indirect downstream effects. Due to its role in chaperoning oncogenic proteins, Hsp90 is an important drug target. However, compounds that occupy the ATP-binding pocket and broadly inhibit function have not achieved widespread use due to negative effects. More selective inhibitors are needed; however, it is unclear how to achieve selective inhibition. We conducted a quantitative proteomic analysis of soluble …

A Multilevel Intervention To Promote Hpv Vaccination Among Young Adults In Texas: Protocol For A Randomized Controlled Trial, Qian Lu, Lenna Dawkins-Moultin, Dalnim Cho, Naomi Q P Tan, Suellen Hopfer, Yisheng Li, Lois Ramondetta, Yusi Xu, Di Lun, Minxing Chen

Faculty, Staff and Student Publications

BACKGROUND: Human papillomavirus (HPV) infections can cause cancers of the cervix, vagina, vulva, penis, anus, and oropharynx. The most recently approved HPV vaccine, Gardasil-9, protects against HPV infection and can prevent HPV-associated invasive cancers. However, Gardasil-9 is one of the most underused vaccines in the US today. Young adults are at risk for HPV infection, but many are not vaccinated. This study uses a randomized controlled trial (RCT) to test an innovative multilevel intervention to increase HPV vaccination rates among young adults. In this paper, we describe the research protocol.

METHODS: The study uses a two by three factorial design. …

A Multilevel Intervention To Promote Hpv Vaccination Among Young Adults In Texas: Protocol For A Randomized Controlled Trial, Qian Lu, Lenna Dawkins-Moultin, Dalnim Cho, Naomi Q P Tan, Suellen Hopfer, Yisheng Li, Lois Ramondetta, Yusi Xu, Di Lun, Minxing Chen

Faculty, Staff and Student Publications

Background: Human papillomavirus (HPV) infections can cause cancers of the cervix, vagina, vulva, penis, anus, and oropharynx. The most recently approved HPV vaccine, Gardasil-9, protects against HPV infection and can prevent HPV-associated invasive cancers. However, Gardasil-9 is one of the most underused vaccines in the US today. Young adults are at risk for HPV infection, but many are not vaccinated. This study uses a randomized controlled trial (RCT) to test an innovative multilevel intervention to increase HPV vaccination rates among young adults. In this paper, we describe the research protocol.

Methods: The study uses a two by three factorial design. …

Histomorphological Evaluation Of Osteoreplacement With Germanium-Doped Calcium Phosphate Ceramics For Model Bone Defects In Rabbits, Tetiana Todosiuk, Mykhailo Rublenko, Valeriy Chemerovskiy, Nataliia Ulianchych, Volodymyr Kolomiiets

Turkish Journal of Veterinary & Animal Sciences

To give calcium phosphate ceramics osteoinductive properties, they are doped with silicon, germanium, zinc, and magnesium ions. The aim of this study was to evaluate the effects of doped and undoped calcium phosphate ceramics on reparative osteogenesis in rabbits. Twenty-four California white rabbits, aged 3 months and weighing 2.5 kg each, were used for the study. The rabbits were divided equally into experimental (n=12) and control (n=12) groups. In the experimental group, defects were replaced with granules of germanium-doped hydroxyapatite ceramics (HA/β-TCP/l-Ge–700), while in the control group, defects were filled with granules of unalloyed ceramics (HA/β-TCP–700). Subsequently, clinical and histological …

Application Of Some Artificial Intelligence Optimization Methods To Determine The Freshness Of Eggs, Hasan Alp Şahi̇n, Hasan Önder

Turkish Journal of Veterinary & Animal Sciences

Egg quality, can be divided into two groups as internal and external, is evaluated using various methods whether breaking eggs. Image processing makes digital images usable for various purposes such as image compression, image editing, object recognition, face recognition, medical imaging, and many other areas such as the automotive industry. This study aimed to determine the freshness of eggs using different artificial intelligence optimization methods with image processing without breaking the eggs. Artificial neural networks (ANNs), artificial bee colony, particle swarm optimization, and genetic algorithms were compared using classification coefficients. As a result of the study, it was determined that …

Features Of Lying Behavior Of Gazella Marica Fawns In Semicaptive Conditions, Adi̇l Uztemur, Abdülkadi̇r Orman

Turkish Journal of Veterinary & Animal Sciences

The lying behavior of Gazella marica fawns was investigated in the gazelle breeding station established to prevent the extinction of this species, whose numbers are decreasing continuously in the wild. There are significant differences between the lying duration in the bedding sites of different kinds (plant-based site, soil-based, side of a stone or rock). Gazella marica fawns were lying on one side of the body 50.23 min on average in the plant-based bed sites, 36.06 min in the soil-based places, and 38.14 min in the stone/ rock area. Gazella marica fawns from semicaptive conditions lied on one body side longer …

Client Perspectives On The Development Of A Rapid Prep Initiative At A Sexual Health Center In New Orleans, Louisiana, Aish Lovett, Rose Luder, Rebecca Lillis, Isolde Butler, Julia Siren, Samuel Gomez, Kevin Kamis, Oluyomi Obafemi, Sarah E. Rowan, Stefan Baral, Meredith E. Clement

School of Medicine Faculty Publications

Uptake of PrEP remains suboptimal, especially in the Southern United States. Same-day or “Rapid PrEP Initiatives” (RPIs) in sexual health centers (SHCs) could facilitate access and overcome barriers to PrEP. We studied the adaptation of an RPI from Denver, Colorado to an SHC in New Orleans, Louisiana. Through focus group discussions (FGDs) with local SHC staff and PrEP providers, we developed a preliminary RPI model. In 5 FGDs with SHC clients referred for or taking PrEP, we gathered adaptation recommendations and feedback on model acceptability, feasibility, and utility. Providers and clients voiced unanimous support for the RPI. Clients favored the …

Reply To: Correlation Between Right Ventricular Echocardiography Measurements And Functional Capacity In Patients With Pulmonary Arterial Hypertension, Annalisa Caputo, Gianmarco Scoccia

The Texas Heart Institute Journal

No abstract provided.

Barriers To And Facilitators Of Paediatric Medical Device Innovation: A Scoping Review Protocol, Lynn Kysh, Grzegorz Zapotoczny, Lisa Manzanete, Megan Carey, Payal Shah, Francesca Joseph, Haley Kempf, Abu Taher Sikder, Julia Finkel, Usha Thekkedath, Kara Toman, Chester J Koh, Kolaleh Eskandanian, Juan Espinoza

Faculty, Staff and Students Publications

INTRODUCTION: The development of paediatric medical devices continues to lag adult medical devices and contributes to issues of inequity, safety, quality and patient outcomes. New legislation and funding mechanisms have been introduced over the past two decades, but the gap remains. Clinical trials have been identified as a pain point, but components of effective clinical research infrastructure are poorly understood. As part of a multimodal research strategy, the Pediatric Device Consortia (PDC) will conduct a scoping review to better understand infrastructural barriers to and facilitators of paediatric medical device clinical research identified in the health sciences literature.

METHODS AND ANALYSIS: …

Sirt6 Protects Retinal Ganglion Cells And Optic Nerve From Degeneration During Aging And Glaucoma, Fan Xia, Shuizhen Shi, Erick Palacios, Wei Liu, Seth E Buscho, Joseph Li, Shixia Huang, Gianmarco Vizzeri, Xiaocheng Charlie Dong, Massoud Motamedi, Wenbo Zhang, Hua Liu

Faculty, Staff and Students Publications

Glaucoma is characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, and its risk increases with aging. Yet comprehensive insights into the complex mechanisms are largely unknown. Here, we found that anti-aging molecule Sirt6 was highly expressed in RGCs. Deleting Sirt6 globally or specifically in RGCs led to progressive RGC loss and optic nerve degeneration during aging, despite normal intraocular pressure (IOP), resembling a phenotype of normal-tension glaucoma. These detrimental effects were potentially mediated by accelerated RGC senescence through Caveolin-1 upregulation and by the induction of mitochondrial dysfunction. In mouse models of high-tension glaucoma, Sirt6 level …

Giant Left Ventricular Aneurysm With Dynamic Right Ventricular Compression And Subsequent End-Stage Heart Failure, Colin A Martz, Jonathan D Moreno, Justin M Vader, Joel D Schilling, Amit Pawale

2020-Current year OA Pubs

We report a case of a patient with a missed anterior myocardial infarction and associated ischemic cardiomyopathy. The patient had a massive true left ventricular aneurysm causing dynamic right ventricular compression, with associated cardiogenic shock, for which a heart transplantation was ultimately performed.

Frontline Assessors' Opinions About Grading Committees In A Medicine Clerkship, Sophia K Lewis, Nathanial S Nolan, Lisa Zickuhr

2020-Current year OA Pubs

BACKGROUND: Collective decision-making by grading committees has been proposed as a strategy to improve the fairness and consistency of grading and summative assessment compared to individual evaluations. In the 2020-2021 academic year, Washington University School of Medicine in St. Louis (WUSM) instituted grading committees in the assessment of third-year medical students on core clerkships, including the Internal Medicine clerkship. We explored how frontline assessors perceive the role of grading committees in the Internal Medicine core clerkship at WUSM and sought to identify challenges that could be addressed in assessor development initiatives.

METHODS: We conducted four semi-structured focus group interviews with …

The Acceptability Of Relationship-Centered Communication Partner Training For Couples Impacted By Aphasia: A Mixed Methods Pilot Investigation, Kathryn-Anne Pertab, Tyson G. Harmon, Jonathan Sandberg, Jon L. Pertab, William S. Evans

Faculty Publications

Purpose: This study explored the acceptability and impact of Relationship-Centered Communication Partner Training (RC-CPT) in couples impacted by aphasia. In particular, couples considered whether discussing their relationship roles and responsibilities was important and relevant to the changes they desire. Preliminary quasi-experimental data regarding perceived communication confidence and the marriage relationship were also obtained.

Method: Three couples participated in RC-CPT across two sessions. Surveys were used to measure communication confidence and the marital relationship before and after participation in RC-CPT. The quantitative findings were analyzed using descriptive statistics. Couples also participated in a semi-structured interview about the acceptability of RC-CPT, during …

Computational Analysis Of O6-Methylated Guanine And Thioguanine Complexes, Kirsten Stinson, Michael Bowman

Lux et Fides: A Journal for Undergraduate Christian Scholars

DNA methylation occurring on the O⁶ position of guanine has been linked to the formation of cancer. DNA complexes with O⁶-methylated guanine have been studied experimentally, yet questions remain concerning the carcinogenic properties of O⁶-methylguanine. This present research explored the interaction between O⁶-methylguanine and its potential nucleobase pairs of cytosine and adenine in hopes of elucidating the mutagenic characteristics of O⁶-methylguanine. A variety of computational methods including Density Functional Theory (DFT), Symmetry Adapted Perturbation Theory (SAPT), Noncovalent Interaction (NCI) analysis, and Natural Bond Orbital (NBO) analysis were employed to comprehensively probe …

Normal Thymus Evaluation Using Radiographs And Computed Tomographic Images In Young And Adult Dogs, Yoenhee Park, Sang-Kwon Lee, Sooyoung Choi, Hojung Choi, Youngwon Lee, Kija Lee

The Thai Journal of Veterinary Medicine

The thymus generally presents as a sail-shaped soft-tissue opacity on thoracic radiographs in young, pre-pubescent dogs. After puberty, lymphatic tissue is replaced by adipose tissue and can usually no longer be identified on radiographs; however, thymic remnants have often been observed in adult dogs. The objective of this retrospective descriptive study was to investigate the incidence of thymic remnants using thoracic radiographs and to analyze the incidence in dogs by age, sex and breed. We analyzed the data from 1,464 dogs that underwent both thoracic ventrodorsal and right lateral radiography, of which 40 underwent both radiography and computed tomography (CT). …

The Role Of Digital Citizenship Using Modern Communication And Media Tools In Enhancing Social Responsibility Among Students Of The Middle East University, Ramzi Mubarak Al Tarawneh Dr, Sahar Mohammad Al Tarawneh Dr

Middle East Journal of Communication Studies

The study aims to explore the role of digital citizenship using modern communication and media tools in enhancing social responsibility among MEU students. A descriptive-analytical approach was used. The study employed a simple random sampling method, with a sample size of 421 students. The findings indicated a statistically significant impact of digital citizenship using modern communication and media tools on social responsibility in its various dimensions. Both digital citizenship using modern communication and media tools and social responsibility were practiced at a high level. Furthermore, a strong correlation was found between digital citizenship using modern communication and media tools and …

Development Of Wireless Device Prototype For Measurement Of Rumen Ph And Temperature Continuously In Cattle, Piyanat Prasomsri, Apirak Tudsorn, Aekaluck Leklerdsiriwong, Chaidate Inchaisri, Siraphop Tooprakai

The Thai Journal of Veterinary Medicine

This study aims to develop a prototype rumen pH and rumen temperature measuring device for continuous measurement. The benefit is for the monitoring and early diagnosis of metabolic diseases in cattle, especially rumen acidosis and subacute ruminal acidosis. The developed prototype device was approximately 50 millimeters in diameter, 145 millimeters in length and weighed 400 grams. The outer structure of the prototype was made from abs plastic made by a 3D printer, while the internal device contained pH and temperature sensors, a microcontroller and battery. The prototype was placed in the ventral sac of the rumen of fistulated cattle for …

Qualitative Risk Analysis On Likelihood Of Foot And Mouth Disease (Fmd) Reintroduction In The Philippines Through The Importation Of Dairy Cattle From Fmd-Free Zones With Vaccination In Brazil, Emerson P. Tapdasan, Kenny Oriel A. Olana

The Thai Journal of Veterinary Medicine

The potential of Girolando cattle from Brazil has generated much interest in the Philippines and the possibility of their importation to contribute to the latter’s dairy industry development has been raised. The most crucial issue that needs to be addressed is the probable introduction of exotic livestock diseases or pathogens of different strains like Foot-and-Mouth Disease virus (FMDv) which might destroy the Philippines’ livestock industry. This study involved only the work required to conduct a preliminary qualitative risk analysis (RA) on the likelihood of FMDv being reintroduced into the Philippines through the importation of Girolando cattle from FMD-free zones with …

The Cost Of Long-Term Care In The Mountain West, 2023, Madison Dwyer, Freddy Nie, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet examines data on the cost of long-term care for the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah from the Genworth “Cost of Care Survey.” Data on long-term care includes home health care, adult day health care facilities, licensed assisted living facilities, and certified and licensed nursing homes.

Less Activity Means Improved Welfare? How Pair Housing Influences Pinyon Jay (Gymnorhinus Cyanocephalus) Behaviour, London M. Wolff, Jeffrey R. Stevens

Center for Brain, Biology, and Behavior: Faculty Publications

The activity level and specific behaviours exhibited by captive animals are crucial indicators of welfare. Stereotypies, or repetitive behaviours that have no apparent function or goal, are performed by animals experiencing poor conditions in their environment and indicate welfare concerns. Changes in the housing environment in particular may have critical influences on behaviour and welfare. Here, we measured behavioural changes in a captive pinyon jay (Gymnorhinus cyanocephalus) population (n = 10) associated with a shift from single to pair housing. Using automated video processing, we show that pair housing greatly reduced overall activity levels in these birds. The …

Effectiveness Of Empiric Carbapenem Versus Non-Carbapenem Therapy For Extended-Spectrum Β-Lactamase Producing Enterobacterales Infections In Non-Intensive Care Unit Patients: A Real-World Investigation In A Hospital With High-Prevalence Of Extended-Spectrum Β-Lactamase Producing Enterobacterales, Amy Y. Kang, Mary Elkomos, Danny Pham, Michelle Guerrero, Deborah Kupferwasser, Loren G. Miller

Pharmacy Faculty Articles and Research

Objective:

To investigate whether empiric carbapenem therapy, compared to empiric non-carbapenem therapy, was associated with improved clinical outcomes among hospitalized, non-intensive care unit (ICU) patients with extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections.

Methods:

We performed a retrospective cohort study of adult, non-ICU patients admitted with ESBL-producing Enterobacterales infections. Primary outcome was time to clinical stability from the first empiric antibiotic dose. Secondary outcomes were early clinical response and 30-day all-cause hospital readmission. We used multivariate regression methods to examine time to clinical stability.

Results:

Of the 142 patients, 59 (42%) received empiric carbapenems and 83 (58%) received empiric …

Restoring, Protecting, And Expanding Abortion Access In The United States: Seeking Consensus Through The Delphi Method, Sarah Pickering

Dissertations and Theses

Background: The Dobbs v. Jackson Women’s Health Organization Supreme Court decision exacerbated inequitable access to abortion in the US. Agreement is needed on which strategies should be prioritized to restore, protect, and expand abortion access.

Methods: We convened a multidisciplinary, geographically diverse Delphi panel of clinical, research, policy, legal, and advocacy experts to reach consensus (i.e., agreement >67%) on recommended actions. Using feedback from three rounds of surveys, and input from a select expert advisory group (N=10), we iteratively refined the statements and recommendations.

Results: The panel (N=85) developed 25 consensus statements and 32 recommendations for action by advocates, funders, …

A One Health Approach To Enhancing Sars-Cov-2 Surveillance, Lauren C. Cybulska

Dissertations and Theses

Background

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes coronavirus disease-2019 (COVID-19) in humans, can also infect domestic dogs (Canis lupus familiaris) and cats (Felis catus). Susceptibility and viral transmissibility in these species are concerns for public health due to the spillover risk to humans or other animals. This dissertation uses a One Health framework to explore key issues on this topic. We aim to identify gaps in understanding of SARS-CoV-2 in companion animals and investigate novel surveillance methods through human, animal, and environmental health perspectives.

Methods

Paper 1 provides an in-depth exploration of …

Debriefer Cognitive Load During Traditional Reflective Debriefing Vs. Rapid Cycle Deliberate Practice Interdisciplinary Team Training, Susan Wiltrakis, Ruth Hwu, Sherita Holmes, Srikant Iyer, Nandranie Goodwin, Claire Mathai, Scott Gillespie, Kiran B Hebbar, Nora Colman

2020-Current year OA Pubs

BACKGROUND: Cognitive load impacts performance of debriefers and learners during simulations, but limited data exists examining debriefer cognitive load. The aim of this study is to compare the cognitive load of the debriefers during simulation-based team training (SbTT) with Rapid Cycle Deliberate Practice (RCDP) debriefing and Traditional Reflective Debriefing (TRD). We hypothesize that cognitive load will be reduced during RCDP compared to TRD.

METHODS: This study was part of a large-scale, interdisciplinary team training program at Children's Healthcare of Atlanta Egleston Pediatric Emergency Department, with 164 learners (physicians, nurses, medical technicians, paramedics, and respiratory therapists (RTs)). Eight debriefers (main facilitators …

Companion-002 A Clinical Trial Of Investigational Drug Ctx-009 Plus Paclitaxel Vs Paclitaxel In Second Line Advanced Btc, Nilofer Azad, Olivia Aranha, Et Al.

2020-Current year OA Pubs

Treatment options for patients with biliary tract cancer are limited, and the prognosis is poor. CTX-009, a novel bispecific antibody targeting both DLL4 and VEGF-A, has demonstrated antitumor activity in patients with advanced cancers as both a monotherapy and in combination with chemotherapy. In a phase II study of patients with advanced biliary tract cancer who had received one or two prior therapies, CTX-009 with paclitaxel demonstrated a 37.5% overall response rate (ORR). Described here is the design of and rationale for COMPANION-002, a randomized phase II/III study, which will evaluate the safety and efficacy of CTX-009 in combination with …