Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (77013)
- Public Health (55623)
- Medical Sciences (45190)
- Life Sciences (42089)
- Nursing (34145)
-
- Social and Behavioral Sciences (33683)
- Diseases (21748)
- Education (19708)
- Rehabilitation and Therapy (16621)
- Mental and Social Health (14561)
- Medical Education (14470)
- Oncology (14295)
- Arts and Humanities (13260)
- Dentistry (13212)
- Physical Sciences and Mathematics (11073)
- Veterinary Medicine (9767)
- Psychiatry and Psychology (9571)
- Pharmacy and Pharmaceutical Sciences (9501)
- Sports Sciences (9142)
- Pediatrics (9034)
- Health and Medical Administration (8960)
- Biomedical Informatics (8887)
- Psychology (8299)
- Sociology (8047)
- Public Health Education and Promotion (7983)
- Bioinformatics (7879)
- Medical Genetics (7027)
- Business (6897)
- Occupational Therapy (6842)
- Institution
-
- The Texas Medical Center Library (25710)
- Thomas Jefferson University (14909)
- Chulalongkorn University (11392)
- Washington University School of Medicine (10520)
- Aga Khan University (9507)
-
- University of Kentucky (8643)
- TÜBİTAK (8080)
- Walden University (6102)
- Western Michigan University (5803)
- Virginia Commonwealth University (5389)
- University of Nebraska - Lincoln (5204)
- Edith Cowan University (4978)
- Western Kentucky University (4358)
- American Dental Association (4336)
- Lehigh Valley Health Network (4096)
- University of Texas Rio Grande Valley (4024)
- Nova Southeastern University (4003)
- Himmelfarb Health Sciences Library, The George Washington University (3652)
- Universitas Indonesia (3624)
- University of Nebraska Medical Center (3617)
- Old Dominion University (3510)
- University of Nevada, Las Vegas (3358)
- Marquette University (3251)
- University of Alabama at Birmingham (3145)
- University of South Carolina (3144)
- Children's Mercy Kansas City (2991)
- Wright State University (2936)
- HCA Healthcare (2908)
- Western University (2904)
- University of North Dakota (2888)
- Keyword
-
- Humans (25725)
- Female (11890)
- Male (10509)
- Animals (7774)
- COVID-19 (7418)
-
- Adult (6187)
- Middle Aged (5222)
- Mice (5144)
- ICTS (Institute of Clinical and Translational Sciences) (5115)
- Aged (4687)
- Child (3569)
- Adolescent (3107)
- United States (2926)
- Michigan (2883)
- Nursing (2616)
- Education (2578)
- Obesity (2496)
- Mental health (2421)
- Depression (2363)
- Public health (2305)
- Retrospective Studies (2270)
- English (2266)
- Pregnancy (2208)
- Cancer (2187)
- Thomas Jefferson University (2032)
- Children (2004)
- Treatment Outcome (1911)
- Young Adult (1829)
- Infant (1765)
- Occupational therapy (1694)
- Publication Year
-
- 2026 (15119)
- 2025 (24515)
- 2024 (27153)
- 2023 (27439)
- 2022 (23780)
-
- 2021 (21401)
- 2020 (20660)
- 2019 (16112)
- 2018 (15421)
- 2017 (14524)
- 2016 (12710)
- 2015 (11981)
- 2014 (9579)
- 2013 (7934)
- 2012 (7323)
- 2011 (6784)
- 2010 (5705)
- 2009 (4384)
- 2008 (3703)
- 2007 (3121)
- 2006 (2765)
- 2005 (2796)
- 2004 (2219)
- 2003 (1917)
- 2002 (1800)
- 2001 (1650)
- 2000 (1582)
- 1999 (1656)
- 1998 (1488)
- 1997 (1145)
- Publication
-
- Faculty, Staff and Student Publications (13668)
- Faculty, Staff and Students Publications (7722)
- 2020-Current year OA Pubs (7374)
- Walden Dissertations and Doctoral Studies (5856)
- Turkish Journal of Medical Sciences (4871)
-
- Theses and Dissertations (4194)
- Chulalongkorn Medical Journal (4154)
- Turkish Journal of Veterinary & Animal Sciences (3209)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (3086)
- International Journal of Exercise Science: Conference Proceedings (2674)
- The Thai Journal of Veterinary Medicine (2528)
- All ETDs from UAB (2525)
- Journal Articles (2396)
- Faculty Publications (2315)
- Research outputs 2022 to 2026 (2303)
- Electronic Theses and Dissertations (2245)
- Henry Ford Hospital Medical Journal (2151)
- Dissertations (1934)
- Loma Linda University Electronic Theses, Dissertations & Projects (1807)
- School of Medicine Publications (1698)
- Doctor of Nursing Practice Projects (1543)
- What's Happening (1535)
- Research outputs 2014 to 2021 (1525)
- Publications and Research (1510)
- Masters Theses (1502)
- Manuscripts, Articles, Book Chapters and Other Papers (1462)
- Dissertations and Theses (Open Access) (1411)
- Dartmouth Scholarship (1400)
- Reproductive Health (1317)
- Rehabilitation Practice and Science (1276)
- Publication Type
Articles 47491 - 47520 of 325679
Full-Text Articles in Medicine and Health Sciences
Personality Profile Of Rural-Dwelling Older Adults With Hoarding Disorder, Mary E. Dozier, Caitlyn A. Nix, Hilary L. Deshong
Personality Profile Of Rural-Dwelling Older Adults With Hoarding Disorder, Mary E. Dozier, Caitlyn A. Nix, Hilary L. Deshong
Journal of Public Health in the Deep South
Hoarding in late life represents a major barrier to aging in place, particularly for rural-dwelling older adults. One risk factor for hoarding disorder in late life may be underlying personality factors. However, there has not yet been an investigation of late life hoarding and possible maladaptive personality factors from the continuous five-factor model perspective in a sample of individuals diagnosed with hoarding disorder. Thus, we evaluated the five-factor personality profiles of older adults enrolled in treatment studies for hoarding disorder in rural Mississippi. Raw scores on the International Personality Item Pool-NEO-60 were converted into categories of Low (<1SD from …1
Chronic Obstructive Pulmonary Disease Hot Spots In Mississippi, Taylor Jansen, Elizabeth Dugan
Chronic Obstructive Pulmonary Disease Hot Spots In Mississippi, Taylor Jansen, Elizabeth Dugan
Journal of Public Health in the Deep South
Abstract
Introduction. Chronic obstructive pulmonary disease (COPD) is the sixth leading cause of death in the US and approximately 10% of people 65 years and older have COPD. This study examines the association of geographic-level risk factors with chronic obstructive pulmonary disease (COPD) prevalence using spatial-based analyses with the goal of identifying risk factors associated with county-level COPD and to identify communities at risk.
Methods. The study sample consisted of all N=82 counties in Mississippi and all data is reported at the county level. All measures were drawn from the 2023 Mississippi Healthy Aging Data Report. A hot spot …
The Mississippi Healthy Aging Data Report: Tools To Advance Health Equity, Elizabeth Dugan, Taylor Jansen, Chae Man Lee, Nina M. Silverstein, Yan-Jhu Su
The Mississippi Healthy Aging Data Report: Tools To Advance Health Equity, Elizabeth Dugan, Taylor Jansen, Chae Man Lee, Nina M. Silverstein, Yan-Jhu Su
Journal of Public Health in the Deep South
Introduction. This article describes the Mississippi Healthy Aging Data Report, which includes 125 indicators reported at the county and state level.
Methods. Data sources include the American Community Survey from the U.S. Census, the Behavioral Risk Factor Surveillance Survey, the Centers for Medicaid and Medicare Services, and other sources. Small-area estimation techniques are used to calculate age- and gender-adjusted county rates. Data visualizations illustrate health disparities.
Results. Mississippi is home to 663,581 people age 60 or older – 22% of the state’s total population. Approximately 12.9% of Medicare beneficiaries in Mississippi have Alzheimer’s disease or a related …
Association Of Self-Report Measures With Salivary Biomarkers In Post-Menopausal Women, Laree M. Hiser, Karen Arrant, Jung Hye S. Lee, Lei Zhang
Association Of Self-Report Measures With Salivary Biomarkers In Post-Menopausal Women, Laree M. Hiser, Karen Arrant, Jung Hye S. Lee, Lei Zhang
Journal of Public Health in the Deep South
Background: Symptoms of menopause include inadequate sleep, depression, and anxiety. Studies of healthy aging frequently use self-report tools that are unverified by objective measures.
Purpose: To investigate the correlation between self-report measures of sleep or affect and salivary biomarkers in a small (n=32) sample of post-menopausal women.
Methods: Salivary cortisol and a-amylase were quantified by laboratory tests. Self-report data included hours of sleep and Patient-Reported Outcomes Measurement Information System (PROMIS®) tools for sleep disturbance, anxiety, and depression. Correlation analyses were conducted between self-reported measures and biomarker concentrations.
Results: No statistically significant correlations were found between cortisol …
Let’S Have A Family Conversation, Kimberly C. Tarver, Kina White
Let’S Have A Family Conversation, Kimberly C. Tarver, Kina White
Journal of Public Health in the Deep South
No abstract provided.
Strategic Advocacy: Doula Care, Liminality, And Reproductive Justice, Julie Johnson Searcy, Ellen Block, Angela N. Castañeda
Strategic Advocacy: Doula Care, Liminality, And Reproductive Justice, Julie Johnson Searcy, Ellen Block, Angela N. Castañeda
Sociology Faculty Publications
No abstract provided.
A Nursing Education Intervention For Delirium Prevention, Sarah Eckles
A Nursing Education Intervention For Delirium Prevention, Sarah Eckles
Doctor of Nursing Practice Projects: College of Nursing
Background
At a large, tertiary care hospital in the Midwest, it had been anecdotally noted that delirium or acute encephalopathy cases were increasing. Specifically, inpatient neurology consultations for delirium were on the rise. This data had been confirmed by hospital administration. Delirium has been identified as a well-known problem in elderly, hospitalized adults—most notably in elderly, postoperative adults. It can cause a cascade of additional complications for elderly patients. Delirium prevention is known to be the best method to combat delirium incidence. Prevention has been proven to occur by way of non-pharmacologic, early interventions by nursing. Bedside nursing staff must …
Exploring The Benefits Of Blazepod Technology Through An Occupational Therapy Lens, Carson Bryan, Cynthia Haynes
Exploring The Benefits Of Blazepod Technology Through An Occupational Therapy Lens, Carson Bryan, Cynthia Haynes
Summer 2024 OTD Capstone Symposium
BlazePod technology is an intervention used successfully in Physical Therapy (PT) to address motor coordination deficits, however, there is limited evidence that OTs can successfully use it as a preparatory intervention with individuals who have motor coordination and cognitive deficits and are unable to independently complete everyday occupations such as dressing, bathing, toileting, etc.
The focus of this project was to provide evidence that supports how the occupational therapy profession can utilize BlazePod technology as a preparatory intervention tool to address motor coordination and cognitive deficits that in turn will enhance ADLs and IADLs.
Education And Training On Naloxone Administration For Healthcare Professionals: An Integrative Literature Review, Remigus C. Nwaokoro
Education And Training On Naloxone Administration For Healthcare Professionals: An Integrative Literature Review, Remigus C. Nwaokoro
DNP Qualifying Manuscripts
Abstract
Background: Healthcare professionals’ lack of knowledge and confidence in administering naloxone affects their willingness to inform at-risk patients about its use in the event of an overdose. The lack of understanding and confidence in using naloxone delays efforts to inform at-risk patients about this life-saving treatment for opioid overdose. This integrative literature review aimed to answer the following question: Do increased education and training enhance healthcare professionals' knowledge and confidence in administering naloxone and decrease the rate of opioid overdose fatalities?
Methodology: A comprehensive search of the literature (2019 and 2024) was conducted to identify studies of education …
The Role Of Ot In Accessible Air Travel For Individuals With Disabilities, Jezaray Clark-Casto, Cynthia Haynes
The Role Of Ot In Accessible Air Travel For Individuals With Disabilities, Jezaray Clark-Casto, Cynthia Haynes
Summer 2024 OTD Capstone Symposium
This capstone project addressed the critical issue of limited accessibility in air travel for individuals with disabilities, in collaboration with All Wheels Up. The project aimed to enhance awareness and provide practical resources to support inclusive air travel practices. Key objectives included developing educational materials, engaging healthcare professionals and industry stakeholders, and integrating accessible air travel concepts into occupational therapy practice.
Increasing Occupational Engagement In Adults With Anxiety And Depression Through Martial Arts, Alfred Franklin, Keisa Boykin
Increasing Occupational Engagement In Adults With Anxiety And Depression Through Martial Arts, Alfred Franklin, Keisa Boykin
Summer 2024 OTD Capstone Symposium
This poster is for a capstone project that developed a martial arts program for adults with anxiety and depression to increase occupational engagement in these individuals.
A Glance Into The Roles Of Higher-Level Academia, Camye White
A Glance Into The Roles Of Higher-Level Academia, Camye White
Department of Occupational Therapy Entry-Level Capstone Projects
This Capstone Project looks at the multiple roles of a full-time faculty member in higher-level academia while looking at implications for best practices to pass the NBCOT certification exam.
Summer Vacation: An Ot Program To Address Social Participation, Ashley Jacobs, Lakeisa Boykin
Summer Vacation: An Ot Program To Address Social Participation, Ashley Jacobs, Lakeisa Boykin
Summer 2024 OTD Capstone Symposium
This project aimed to develop asix-week program that addresses the development of social skills during summer vacation for children and adolescents who demonstrate difficulties with social engagement. The program will focus on initiating, building, and maintaining friendships with peers to encourage increased social engagement.
Flow: An Ot-Based Yoga Program, Na'talia Orebeau, Keisa Boykin, Sadé Barnswell
Flow: An Ot-Based Yoga Program, Na'talia Orebeau, Keisa Boykin, Sadé Barnswell
Summer 2024 OTD Capstone Symposium
At-risk youth are at risk for decreased mental wellness and occupational engagement. There are limited programs available from an occupational therapist standpoint for the population. Flow: An OT-Based Yoga Program focused on bridging this gap by providing a 10-week program focusing on emotional regulation skills, social skills, and occupational engagement.
Cycle Syncing: Optimizing Women's Quality Of Life, Megan Francois
Cycle Syncing: Optimizing Women's Quality Of Life, Megan Francois
Theses and Graduate Projects
A woman’s hormones are in constant fluctuation throughout the menstrual cycle. This 28-day, on average, fluctuation can cause major shifts in mood, cognition, exercise tolerance, and nutrition needs. Because of this, there is potential to optimize quality of life if each phase is synced with diet, exercise, and complementary medicine utilizing holistic methods. Implications for further research include a need for additional longitudinal and prospective studies. Factors that need to be addressed include further analysis of the windows of vulnerability over the menstrual cycle according to female hormone fluctuations, effects of hormonal contraceptives, and effects of pathology on the cycle.
Preserving Pediatric Wellness: Enhanced Recovery After Surgery Protocols And Pain Management In Pediatric Surgery, Kimberly Kim
Preserving Pediatric Wellness: Enhanced Recovery After Surgery Protocols And Pain Management In Pediatric Surgery, Kimberly Kim
Theses and Graduate Projects
Background: Enhanced recovery after Surgery (ERAS) protocols and multimodal pain management strategies have revolutionized perioperative care in adult surgical practice by leading to improved postoperative outcomes and better pain management. However, the adoption of these protocols to pediatric surgical care remains underexplored.
Purpose: This systematic review aims to examine recent randomized clinical trials on the implementation of ERAS protocols and multimodal pain management strategies in pediatric surgical patients.
Methods: A computer-based literature search of databases through Google Scholar and PubMed with manual reference searches was used to identify eligible studies. The review includes randomized controlled trials focusing on multimodal pain …
Digital Scribes: A Possible Solution For Provider Burnout By Reducing Provider Workload, Shannon Storley
Digital Scribes: A Possible Solution For Provider Burnout By Reducing Provider Workload, Shannon Storley
Theses and Graduate Projects
Background: Provider burnout is continuing to be a massive problem for our healthcare industry. One major contributor to provider burnout is burdensome administrative tasks associated with documentation of electronic medical records (EMR). This review aims to uncover the applications for artificially intelligent digital scribes as a solution to reduce EMR documentation burden. Purpose: Provider burnout has shown to increase the incidence of major mistakes and decreased patient safety grades. Digital scribes could be a solution in reducing provider burnout by reducing the administrative burden of EMR documentation. Methods: A comprehensive literature review was conducted using articles from PubMed using search …
Queering Pa School: An Audit Of Augsburg University’S Physician Assistant Program Regarding Lgbtq+ Related Health Topics, Annika Kuchar
Queering Pa School: An Audit Of Augsburg University’S Physician Assistant Program Regarding Lgbtq+ Related Health Topics, Annika Kuchar
Theses and Graduate Projects
Background: Historically LGBTQ+ people have encountered discrimination in the world of medicine, and often providers are sometimes unaware of how to manage medical issues of these patients. In order to best serve queer and trans patients, a more coherent, consistent curriculum needs to be established so that all medical professions are capable of giving high quality treatment to these patients. Physician assistants (PAs) are advanced practice providers who take care of LGBTQ+ patients on a daily basis and are trained under a similar model as physicians. PA programs must also be up to date on the most culturally sensitive ways …
Barriers Primary Care Physician Assistants Face In Referring Patients To Palliative Care Services Early In The Disease Process, Claire Petersen
Barriers Primary Care Physician Assistants Face In Referring Patients To Palliative Care Services Early In The Disease Process, Claire Petersen
Theses and Graduate Projects
Background: Medical specialties such as hospice and palliative care have been proven to improve quality of life for patients facing end-of-life and chronic illness. Though increasing awareness of these specialties has resulted in greater availability, it is essential to investigate the barriers clinicians, such as Physician Assistants, face in making these referrals in order to provide quality healthcare to those who need it. Physician Assistants specifically are an essential clinician group to evaluate, as they continue to become more prevalent in the healthcare system.
Purpose: To determine barriers primary care Physician Assistants face when identifying candidates for and referring to …
Unveiling Healthcare Disparities By Addressing Historical Traumas To Build Inclusive Spaces For Marginalized Communities: An Autoethnographic Study, Helena Humphreys
Unveiling Healthcare Disparities By Addressing Historical Traumas To Build Inclusive Spaces For Marginalized Communities: An Autoethnographic Study, Helena Humphreys
Theses and Graduate Projects
This paper delves into the pervasive disparities within the healthcare system, rooted in historical injustices that are perpetuated by systemic biases, particularly affecting Black, Indigenous, and People of Color (BIPOC) communities, as well as the LGBTQIA2S+ community. Through a comprehensive literature review and autoethnographic study, the paper examines the deep-seated issues faced by these marginalized groups, including access barriers, discrimination, mistrust of healthcare providers, and the enduring impact these have on health outcomes. Historical traumas such as the Tuskegee Syphilis Study and the use of HeLa cells underscore the enduring impact of past injustices on present-day healthcare experiences. Moreover, the …
Aquatics As A Therapeutic Intervention And Its Effects On The Quality Of Life Of People Diagnosed With Amyotrophic Lateral Sclerosis, Brianna Barcelo, Lakesia Boykin, Helen Carey
Aquatics As A Therapeutic Intervention And Its Effects On The Quality Of Life Of People Diagnosed With Amyotrophic Lateral Sclerosis, Brianna Barcelo, Lakesia Boykin, Helen Carey
Summer 2024 OTD Capstone Symposium
: Interventions in the form of aquatics have been utilized with the profession of occupational therapy as the aquatic environment is a model setting for addressing occupational therapy interests (Becker, 2009). Although aquatic interventions are utilized within profession, there is limited research discussing how aquatics as a therapeutic intervention effects the quality of life (QoL) of people diagnosed with ALS. Therefore, the purpose of the research project was to explore the effects of aquatics as a therapeutic intervention on the QoL of those diagnosed with ALS.
Karate For Adolescent’S Mental Health, Brooke Albertson, Lakeisa Boykin, Amanda Piepgras
Karate For Adolescent’S Mental Health, Brooke Albertson, Lakeisa Boykin, Amanda Piepgras
Summer 2024 OTD Capstone Symposium
Description: Mental health is essential for overall health because it affects emotional, psychological, and social well-being, which affects how individuals feel, act, and think (Center for Disease [CDC], 2022). Everyone can react differently to the same issue, which can cause diverse health risks (Gopalkrishnan, 2018). Mental health affects how people handle stress, interact with others, make choices, and participate in occupations that are important to them (CDC, 2022). Mental health issues are most prevalent in young adult, teen, and pre-teen populations.
By promoting based karate program, occupational therapy can prevent and/or reduce mental health issues (Bird, et al., 2019; Jurewicz, …
The Transition From In Person Sessions To Telemental Health Sessions For College Counseling Center Counselors, Katherine L. Karimian
The Transition From In Person Sessions To Telemental Health Sessions For College Counseling Center Counselors, Katherine L. Karimian
Doctoral Dissertations
This study was conducted by applying Interpretative Phenomenological Analysis (IPA) to explore the lived experiences of college counseling center (CCC) counselors during their rapid switch from in person to online services as a result of university and colleges moving to remote education during the peak of the COVID-19 pandemic (~March 2020 - August 2021). Six participants from different regions of the United States were interviewed via Zoom and analyzed through IPA. There were five themes that emerged:Blurred work/home boundaries, interpersonal relationships within work setting, adapting to teletherapy, impact of teletherapy on services, and preferring remote work. Emergent subthemes were parenting, …
Optimizing Care Delivery: Determining The Impact Of A Mobile Interpreter App On Patient Satisfaction, Leslie M. Bright
Optimizing Care Delivery: Determining The Impact Of A Mobile Interpreter App On Patient Satisfaction, Leslie M. Bright
Doctoral Dissertations and Projects
Introduction: Patients with limited English proficiency (LEP) experience increased health disparities including poorer health outcomes, lack of access to quality healthcare services, and decreased patient satisfaction related to cultural and language barriers.
Purpose/Significance: The purpose of this project was to determine the impact of a technology-based mobile app used for medical interpreter services on patient satisfaction in patients with LEP during urgent care visits.
Methods: The project design consisted of a mobile interpreter app used for medical translation services during urgent care visits. Pretest and posttest patient satisfaction questionnaires were administered before and after the mobile app use to determine …
Inactivated Rabies-Based Lassa Fever Virus Vaccine Candidate Lassarab Protects Nonhuman Primates From Lethal Disease, Gabrielle Scher, Catherine Yankowski, Drishya Kurup, Nicole Josleyn, Eric Wilkinson, Jay Wells, Jesse Steffens, Ginger Lynn, Sean Vantongeren, Xiankun Zeng, Nancy Twenhafel, Kathleen Cashman, Matthias Schnell
Inactivated Rabies-Based Lassa Fever Virus Vaccine Candidate Lassarab Protects Nonhuman Primates From Lethal Disease, Gabrielle Scher, Catherine Yankowski, Drishya Kurup, Nicole Josleyn, Eric Wilkinson, Jay Wells, Jesse Steffens, Ginger Lynn, Sean Vantongeren, Xiankun Zeng, Nancy Twenhafel, Kathleen Cashman, Matthias Schnell
Department of Microbiology and Immunology Faculty Papers
Lassa fever virus (LASV), a member of the Arenavirus family, is the etiological agent of Lassa fever, a severe hemorrhagic disease that causes considerable morbidity and mortality in the endemic areas of West Africa. LASV is a rodent-borne CDC Tier One biological threat agent and is on the World Health Organization's (WHO) Priority Pathogen list. Currently, no FDA-licensed vaccines or specific therapeutics are available. Here, we describe the efficacy of a deactivated rabies virus (RABV)-based vaccine encoding the glycoprotein precursor (GPC) of LASV (LASSARAB). Nonhuman primates (NHPs) were administered a two-dose regimen of LASSARAB or an irrelevant RABV-based vaccine to …
Improved Robustness For Deep Learning-Based Segmentation Of Multi-Center Myocardial Perfusion Mri Datasets Using Data Adaptive Uncertainty-Guided Space-Time Analysis., Dilek M Yalcinkaya, Khalid Youssef, Bobak Heydari, Janet Wei, Noel Bairey Merz, Robert Judd, Rohan Dharmakumar, Orlando P Simonetti, Jonathan W Weinsaft, Subha V Raman, Behzad Sharif
Improved Robustness For Deep Learning-Based Segmentation Of Multi-Center Myocardial Perfusion Mri Datasets Using Data Adaptive Uncertainty-Guided Space-Time Analysis., Dilek M Yalcinkaya, Khalid Youssef, Bobak Heydari, Janet Wei, Noel Bairey Merz, Robert Judd, Rohan Dharmakumar, Orlando P Simonetti, Jonathan W Weinsaft, Subha V Raman, Behzad Sharif
Heart and Vascular Articles
BACKGROUND: Fully automatic analysis of myocardial perfusion MRI datasets enables rapid and objective reporting of stress/rest studies in patients with suspected ischemic heart disease. Developing deep learning techniques that can analyze multi-center datasets despite limited training data and variations in software (pulse sequence) and hardware (scanner vendor) is an ongoing challenge.
METHODS: Datasets from 3 medical centers acquired at 3T (n = 150 subjects; 21,150 first-pass images) were included: an internal dataset (inD; n = 95) and two external datasets (exDs; n = 55) used for evaluating the robustness of the trained deep neural network (DNN) models against differences in …
Understanding The Role Of Mastl In Colon Homeostasis And Colitis-Associated Cancer Development, Kristina Pravoverov
Understanding The Role Of Mastl In Colon Homeostasis And Colitis-Associated Cancer Development, Kristina Pravoverov
Theses & Dissertations
Colitis-associated cancer (CAC) is the most devastating complication of longstanding inflammatory bowel disease (IBD). Understanding the mechanisms underlying the switch from damage-repair to dysplasia in IBD is critical for identifying novel therapies to facilitate mucosal healing while mitigating CAC risk. Microtubule-associated serine-threonine kinase-like (MASTL), though crucial in cell growth and repair, is upregulated in sporadic colorectal cancer and CAC. This study sought to delineate the role of MASTL in colitis and CAC development.
First, we examined whether MASTL is associated with colitis and recovery. Review of publicly available data found significant elevation of MASTL and interleukin (IL)-22 in biopsies from …
Central Nervous System Antiviral Pharmacology, Sean N. Avedissian
Central Nervous System Antiviral Pharmacology, Sean N. Avedissian
Theses & Dissertations
Soon after viral infection, viruses like Human Immunodeficiency Virus (HIV) and SARS-CoV-2 can disseminate throughout the body and establish reservoirs in the central nervous system (CNS). The persistence of viruses in cells of these reservoirs is a major obstacle to virus eradication. This is due to the abundance of cells/receptors that these viruses utilize to gain entry into cells found at these various reservoir sites. Consequently, these same anatomical sites also may be pharmacologic sanctuaries, as evidenced by concentrations of antiretroviral drugs (ARVs) and antivirals (AVs) that are lower in reservoirs than those in peripheral blood; in some cases, these …
Ct Scan Identified Sarcopenia And The Relationship With The Mst And And/Aspen Malnutrition Guidelines In Gastrointestinal Cancer Patients, Samantha Dieckmann
Ct Scan Identified Sarcopenia And The Relationship With The Mst And And/Aspen Malnutrition Guidelines In Gastrointestinal Cancer Patients, Samantha Dieckmann
Theses & Dissertations
Sarcopenia is a debilitating muscle loss disorder caused by aging or chronic conditions. It decreases quality of life and increases morbidity and mortality. Gastrointestinal cancer patients are at a high risk for the condition given the impact of the disease and its treatments. There is limited consensus on how to identify and screen for sarcopenia. Previous research is limited on the use of clinically available tools currently used for malnutrition and their ability to screen for sarcopenia. This study aimed to investigate the Malnutrition Screening Tool (MST) and the Academy of Nutrition and Dietetics, and the American Society for Parenteral …
Association Between Agrichemical Mixtures And Pediatric Health Outcomes: Evidence From A Nebraska Population-Based Surveillance, Jabeen Taiba
Theses & Dissertations
Human exposure to environmental contaminants is associated with various pediatric health outcomes. Agrichemicals are a significant environmental risk factor for childhood cancers and congenital anomalies, and reduced exposure could improve pediatric health outcomes. Previous studies in Nebraska have explored the association between single pollutants and pediatric cancers and birth defects. However, it is important to estimate the overall effect of the agrichemical mixture on these pediatric health outcomes. In addition to environmental risk factors, several social vulnerability factors also contribute to increased agrichemical exposure and show disparities in pediatric cancers and birth defects. The objectives of this dissertation are to …