Medicine and Health Sciences Commons^™

Infratubercle Anterior Closing Wedge Osteotomy Corrects Sagittal Alignment Without Affecting Coronal Alignment Or Patellar Height, Shintaro Onishi, Youngji Kim, Hiroshi Nakayama, Alfred A Mansour, Walter R Lowe, Matthieu Ollivier

Faculty, Staff and Student Publications

Background: Excessive posterior tibial slope (PTS) has been associated with a higher risk of graft failure after anterior cruciate ligament reconstruction (ACLR). Although anterior closing wedge osteotomy (ACWO) can reduce the PTS, it may also change the coronal alignment and patellar height. Purpose: To elucidate the radiological outcomes after infratubercle ACWO, specifically to evaluate its influence on perioperative changes in patellar height.

Methods: Patients who underwent infratubercle ACWO with combined ACLR with a minimum follow-up of 3 months were included. Surgery was indicated when the PTS was greater than 12°. Radiological evaluation included measurements of the hip-knee-ankle angle (HKA), PTS, …

Sailing Is For Everyone: Developing An Adaptive Sailing Program For Seattle's Community Boating Center, Karoline J. Ashpole

OTD Capstone Projects

This doctoral capstone project was in partnership with Seattle’s community boating center, Sail Sand Point (SSP). SSP’s mission is “to bring the joy and life-enhancing benefits of sailing and small boats to people of all ages, abilities, and backgrounds”. This project aimed to develop adaptive sailing programming to increase sailing access to individuals with disabilities. This included expanding the partnership with Outdoors For All, an adaptive outdoor recreation organization in Seattle. Through this partnership we hosted their summer camp for five sailing days with five additional days planned for after the completion of this project, demonstrating program sustainability and longevity. …

A Systematic Review: Longevity And Quality Of Life In Blue Zones, Salmaan Mulla

Theses and Graduate Projects

Ikaria, Loma Linda, Sardinia, Okinawa, and Nikoya. These 5 cities around the world are famed for their increased longevity and quality of life and are termed “Blue Zones”. Blue zones are areas around the world noted for their population of centenarians, overall long life expectancy and high quality of life compared to the average population. Studying these communities offer insights into the commonalities they share to better understand the unique aspects of living a healthy, fulfilling and long life. A comprehensive literature review was conducted using Google Scholar, with the search terms “Ikaria, Greece longevity; Loma Linda, California longevity; Sardinia, …

Antibiotic Resistance In Livestock: A Literature Review Of Its Consequences And International Effort On Human Antimicrobial Agents Resistant Crisis, Ha Nguyen

Theses and Graduate Projects

Background: Despite their benefits, the overuse of antibiotics in livestock has resulted in negative consequences to human health and the augmenting of an antibiotic-resistant crisis. Countries worldwide have conducted analyses and confirmed the growth of bacterial strains immune to most antibiotics. The widespread use of antibiotics is shown in various sectors, including human medicine and agriculture, leading to the emergence of antibiotic-resistant bacterial strains.

Purpose: This comprehensive literature review focuses on finding the connection between the usage of antibiotics in livestock, the transfer of antibiotic resistance to humans through consumption and exposure, and international efforts to find solutions to antimicrobial …

Bringing An Understanding Of Elementary School Teachers’ Rationale For Their Classroom Design To Ot Practice, Hannah Berry, Otd, Mscaot, Otr

Post-Professional Occupational Therapy Doctorate Culminating Presentations

Introduction

Physical, sensory, and social aspects of the classroom environment directly influence students’ behavior, learning and academic achievement. Both teachers and occupational therapy practitioners (OTPs) approach the design, adaptation, and use of the classroom from their respective knowledge base (Wintle, et al, 2022). Grandisson et al. (2020) noted that OTPs can often know very little about the school personnel, their pedagogy, the school culture, or the classroom routines. This can lead to a disconnect between OTPs recommendations for classroom environment modifications and teachers’ design and use of the same space.

Objectives

The purpose of this study was to explore the …

Injectable Formulations For Localized Delivery Of Immunomodulators, Ketki Velankar

Electronic Theses and Dissertations

Dysregulation of immune homeostasis is fundamental to the development of autoimmune disorders. Fibroblastic reticular cells (FRCs) within lymph nodes play crucial roles in forming a microenvironment conducive to immune cell interactions and regulating autoreactive T cells driving autoimmune diseases. Studies have shown the potential of FRCs as a form of personalized cell therapy to correct dysregulated immune responses. Successful translational efforts, however, require the cells to be formulated as injectable suspensions while retaining their native architecture, which is essential for their regulatory functions. The main challenge resides in retaining the native reticular organization of FRCs lost in conventional monolayer cultures …

The Ethical Duty Of Care For Suicide Ideation, Tah Ngijoi Yogo

Electronic Theses and Dissertations

With suicide being a leading global cause of death, there is a need to explore the ethical complexities surrounding suicide and preventive measures. This dissertation questions the morality of suicide by examining the historical and philosophical dimensions across cultures and religions. The text argues for an approach that acknowledges rational suicide while developing the ethics of paternalistic measures for suicide prevention of vulnerable populations.

Considering the ethics of autonomy, the dissertation discusses the practice of nudging in healthcare to highlight the role of paternalism in supporting informed consent. The text proposes an enhanced autonomy model that balances trust, influence, and …

Coaching In Context Fidelity Measure: A Linguistic Validation To Hispano-America Spanish, Jorge L. Torres-Vélez, Otd, Otr/L

Post-Professional Occupational Therapy Doctorate Culminating Presentations

Introduction

Coaching in Context (CinC) is an emerging intervention approach used by occupational therapy practitioners (OTPs). A growing body of literature has found CinC to be effective when used by OTPs with various clients. The CinC approach was manualized by publishing a visual representation of the model and developing a fidelity measure. Both were written in English by North American English-speaking researchers. Recently, the CinC Fidelity Measure was translated into Spanish to be used by Spanish-speaking OTPs but there was a need to conduct a linguistic validation to avoid difficulties in implementation, due to poor comprehension, and avoid inaccurate, misinterpreted, …

Workload Model In School-Based Occupational Therapy Practice: Administrators' Perspective, Rachel K. Boileau, Otd, Ms, Otr/L

Post-Professional Occupational Therapy Doctorate Culminating Presentations

Background: School-based occupational therapy practitioners (OTPs) experience alarming levels of burnout and poor work satisfaction related to excessive caseload (Garfinkel & Seruya, 2018; Stephenson, 2019). The workload model has the potential for positive results (AOTA, 2014), as it compensates an OTP for all tasks performed, not just student-facing time (Garfinkel & Seruya, 2018; Corley et al., 2023). However, this model, has been promoted by the American Occupational Therapy Association for more than a decade, is not widely used (Garfinkel & Seruya, 2018; Corley et al., 2023). The reasons for the slow espousal of the model are not yet understood, but …

Home Health “Start Of Care” Policy Change: Examining Occupational Therapist Engagement In New Responsibilities, Megan Atkinson, Otd, Ma, Otr/L

Post-Professional Occupational Therapy Doctorate Culminating Presentations

A 2022 federal policy change allowed occupational therapists (OTs) to open home health cases in a process known as the Start of Care or SOC, a responsibility previously limited to nurses, physical therapists, and speech-language pathologists. The American Occupational Therapy Association (AOTA) recognizes the opportunity for increased professional value and service utilization and called upon practitioners to advocate such and to educate home health agencies about the change. Since clinicians’ practice patterns are directly impacted by such policy changes, because current OT participation in and perspective on new responsibilities were unknown, it was important to hear directly from these therapists. …

Creation Of A Predictive Calculator To Determine Adequacy Of Occlusion Of The Woven Endobridge (Web) Device In Intracranial Aneurysms-A Retrospective Analysis Of The Worldwide Web Consortium Database, Basel Musmar, Nimer Adeeb, Julian Gendreau, Melanie Alfonzo Horowitz, Hamza Adel Salim, Praveen Sanmugananthan, Assala Aslan, Nolan J Brown, Nicole M Cancelliere, Rachel M Mclellan, Oktay Algin, Sherief Ghozy, Mahmoud Dibas, Atakan Orscelik, Yigit Can Senol, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Kevin Premat, Markus Möhlenbruch, Michael Kral, Omer Doron, Charlotte Chung, Mohamed M Salem, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Hamza Shaikh, Vedran Župančić, Muhammad U Hafeez, Joshua Catapano, Muhammad Waqas, Vincent M Tutino, Yuce Gokhan, Cetin Imamoglu, Ahmet Bayrak, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer E Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T Nawka, Marios Psychogios, Christian Ulfert, Jose Danilo Bengzon Diestro, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Muhammed Amir Essibayi, Sunil A Sheth, Gary Spiegel, Rabih Tawk, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Erez Nossek, Eytan Raz, Monika Killer-Oberfalzer, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Allan L Brook, David Altschul, Andrew F Ducruet, Felipe C Albuquerque, Robert W Regenhardt, Christopher J Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Stavropoula I Tjoumakaris, Frédéric Clarençon, Nicola Limbucci, Mohamad Bydon, David Hasan, Hugo H Cuellar-Saenz, Pascal M Jabbour, Vitor Mendes Pereira, Aman B Patel, Adam A Dmytriw

Faculty, Staff and Student Publications

Background: Endovascular treatment with the woven endobridge (WEB) device has been widely utilized for managing intracranial aneurysms. However, predicting the probability of achieving adequate occlusion (Raymond-Roy classification 1 or 2) remains challenging.

Objective: Our study sought to develop and validate a predictive calculator for adequate occlusion using the WEB device via data from a large multi-institutional retrospective cohort.

Methods: We used data from the WorldWide WEB Consortium, encompassing 356 patients from 30 centers across North America, South America, and Europe. Bivariate and multivariate regression analyses were performed on a variety of demographic and clinical factors, from which predictive factors were …

Uptake Of Extracellular Vesicles Into Brain Endothelial Cells And Development Of Motor Neuron-Derived Extracellular Vesicles For Amyotrophic Lateral Sclerosis, Jhanvi Rajan Jhaveri

Electronic Theses and Dissertations

Extracellular vehicles (EVs) are an emerging class of drug carriers and are primarily reported to be internalized into recipient cells via a combination of endocytic routes such as clathrin-mediated, caveolae-mediated and macropinocytosis pathways. In part one of this thesis, (1) we investigated potential effects of homotypic vs. heterotypic interactions by studying the cellular uptake of homologous EVs (EV donor cells and recipient cells of the same type) vs. heterologous EVs (EV donor cells and recipient cells of different types) and (2) determined the route of EV internalization into low pinocytic/hard-to-deliver cell models such as brain endothelial cells ( …

Delivery Of Mitochondria-Containing Engineered Extracellular Vesicles To The Blood-Brain Barrier For Ischemic Stroke Therapy, Kandarp Dave

Electronic Theses and Dissertations

Ischemic stroke is the second leading cause of death worldwide, and the lack of effective treatment options is an unmet clinical need for stroke survivors. Ischemic stroke-induced oxygen-glucose deprivation (OGD) in the affected brain tissue leads to mitochondrial dysfunction and adenosine triphosphate (ATP) depletion in the brain endothelial cells (BECs) lining the blood-brain barrier (BBB). ATP deprivation in the BECs dysregulates actin cytoskeleton dynamics, resulting in BBB breakdown. Restoration of blood flow (i.e., reperfusion) upon the first-line stroke treatment further leads to BBB breakdown and widens the paracellular spaces between BECs. …

Influence Of Cbct Different Radiation Doses On Mandibular Soft Tissue Thickness Measurements, Marwa Ezz Elarab, Mahinaz Reda Abdelhamed

Dentistry

Purposes: Study the influence of changing CBCT radiation doses (using ultra low dose and high dose systems) on soft tissues thickness measurements and compare the results with the direct measurements method. Methods:9 fresh pig mandiblue were utilized for each of two CBCT scan systems (Planmeca Promax 3D MID). Nine disposable needles were inserted into the gingival tissue of each jaw until reaching resistance from the underlying bone. A mark on each needle at its entrance point into the soft tissue was created using a permanent marker. Jaws were scanned twice, using ultra low (Rad UL) and high (Rad H) exposure …

Developmental Positioning In The Nicu, Megan Litteken

MSN Capstone Projects

For at least the past decade, one in ten infants born in the United States have delivered prematurely or before the 37^th week of gestation (March of Dimes, 2024b). As a result, there are a variety of both short- and long-term effects on the infant that include both physical and neuromotor developmental delays requiring follow-up after discharge (March of Dimes, 2024b). The extent of these delays depends on how early the infant is born and any associated congenital factors; however, the care provided in the Neonatal Intensive Care Unit (NICU) may help reduce the effects or length of these …

Reducing Compassion Fatigue On A Cardiac Telemetry Unit, Nicole Rocio Garzon

Master's Projects and Capstones

Abstract

Background: Compassion fatigue (CF) among nurses is a significant concern affecting both individual well-being and patient care outcomes. Findings from a 2020 national survey found two-thirds of nurses (62%) struggle with CF and even a high rate for those nurses under the age of 25 years. Through a review of current literature and case studies, the effectiveness of these interventions in reducing stress, enhancing resilience, and improving overall job satisfaction among healthcare professional is examined. Practical implications for implementing these interventions in healthcare organizations are discussed, emphasizing the potential for creating supportive environments that foster emotional and mental well-being …

Patient-Reported Outcomes From The Phase Iii Himalaya Study Of Tremelimumab Plus Durvalumab In Unresectable Hepatocellular Carcinoma, Bruno Sangro, Peter R. Galle, Robin Kate Kelley, Chaiyut Charoentum, Enrico N. De Toni, Yurii Ostapenko, Jeong Heo, Ann-Lii Cheng, Andrea Wilson Woods, Charu Gupta, Jayne Abraham, Carrie L. Mccoy Phd, Rn, Anp-Bc, Nikunj Patel, Alejandra Negro, Arndt Vogel, Ghassan K. Abou-Alfa

Publications

PURPOSE:

In the phase III HIMALAYA study (ClinicalTrials.gov identifier: NCT03298451) in unresectable hepatocellular carcinoma (uHCC), the Single Tremelimumab Regular Interval Durvalumab (STRIDE) regimen significantly improved overall survival versus sorafenib, and durvalumab monotherapy was noninferior to sorafenib. Patient-reported outcomes (PROs), a secondary outcome from HIMALAYA, are reported here.

METHODS:

Participants were randomly assigned to receive STRIDE, durvalumab, or sorafenib. PROs were assessed (preplanned secondary outcome) using the European Organization for Research and Treatment of Cancer 30-item Quality of Life Questionnaire and the 18-item HCC module. Time to deterioration (TTD), change from baseline and improvement rate in global health status/quality of life …

Addressing Medication Adherence Barriers In Hispanics Diagnosed With Diabetes Type Ii, Solmayra Solis

Doctor of Nursing Practice Final Project Abstract

The purpose of this scholarly project was to identify and mitigate the barriers of medication adherence in an underserved population of Hispanic patients diagnosed with Type II diabetes through a nurse-driven telephone follow-up program. The program aims to assess and offer solutions available in the clinic to barriers of medication adherence. The project was implemented at the non-profit Christ Clinic located in Katy, TX. About 94% of the population are Spanish-speaking Hispanics and 200% below the federal poverty level. The patients do not have insurance due to their immigration status. Of the 5,000 clinic patients, an estimated 40% are non-medication …

Dual Inhibition Of The Trka And Jak2 Pathways Using Entrectinib And Pacritinib Suppresses The Growth And Metastasis Of Her2-Positive And Triple-Negative Breast Cancers, Angelina T Regua, Shivani Bindal, Mariana K Najjar, Chuling Zhuang, Munazza Khan, Austin B J Arrigo, Anneliese O Gonzalez, Xinhai R Zhang, Jay-Jiguang Zhu, Kounosuke Watabe, Hui-Wen Lo

Faculty, Staff and Student Publications

HER2-positive and triple-negative breast cancers (TNBC) are difficult to treat and associated with poor prognosis. Despite showing initial response, HER2-positive breast cancers often acquire resistance to HER2-targeted therapies, and TNBC lack effective therapies. To overcome these clinical challenges, we evaluated the therapeutic utility of co-targeting TrkA and JAK2/STAT3 pathways in these breast cancer subtypes. Here, we report the novel combination of FDA-approved TrkA inhibitors (Entrectinib or Larotrectinib) and JAK2 inhibitors (Pacritinib or Ruxolitinib) synergistically inhibited in vitro growth of HER2-positive breast cancer cells and TNBC cells. The Entrectinib-Pacritinib combination inhibited the breast cancer stem cell subpopulation, reduced expression of stemness …

Absence Of Motor Impairments Or Pathological Changes In Tmem230 Knockout Rats, Wenjuan Zhang, Hao Peng, Daihe Yang, Guohua Song, Juan He, Yun Zhou, Cao Huang, Bo Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Parkinson's disease (PD), which is the second most common neurodegenerative disorder, is characterized by progressive movement impairment and loss of midbrain dopaminergic neurons in the substantia nigra. Although mutations in TMEM230 are linked to familial PD, the pathogenic mechanism underlying TMEM230-associated PD remains to be elucidated. To explore the effect of TMEM230 depletion in vivo, we created TMEM230 knockout rats using CRISPR-Cas9 technology. TMEM230 knockout rats did not exhibit any core features of PD, including impaired motor function, loss of dopaminergic neurons in the substantia nigra, or altered expression of proteins related to autophagy, the Rab family, or vesicular trafficking. …

Phase I Trial Of Gd2cart Cells Augmented With Constitutive Interleukin-7 Receptor For Treatment Of High-Grade Pediatric Cns Tumors, Frank Y Lin, Austin Stuckert, Candise Tat, Mark White, Lucia Ruggieri, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Angela Major, Sachin Thakkar, Thomas Shum, Kathan Parikh, Meng-Fen Wu, Holly B Lindsay, Lauren Scherer, Meghan Shekar, Patricia Baxter, Tao Wang, Bambi Grilley, Karen Moeller, John Hicks, Angshumoy Roy, Jamie Anastas, Fatema Malbari, Guillermo Aldave, Murali Chintagumpala, Susan Blaney, D Williams Parsons, Malcolm K Brenner, Helen E Heslop, Cliona M Rooney, Bilal Omer

Center for Medical Ethics and Health Policy Staff Publications

Purpose: T cells modified with chimeric antigen receptors (CARTs) have demonstrated efficacy for hematologic malignancies; however, benefit for patients with CNS tumors has been limited. To enhance T cell activity against GD2+ CNS malignancies, we modified GD2-directed CART cells (GD2.CARTs) with a constitutively active interleukin (IL)-7 receptor (C7R-GD2.CARTs).

Methods: Patients age 1-21 years with H3K27-altered diffuse midline glioma (DMG) or other recurrent GD2-expressing CNS tumors were eligible for this phase I trial (ClinicalTrials.gov identifier: NCT04099797). All subjects received standard-of-care adjuvant radiation therapy or chemotherapy before study enrollment. The first treatment cohort received GD2.CARTs alone (1 × 107 cells/m2), and …

Signaling By A Bacterial Phytochrome Histidine Kinase Involves A Conformational Cascade Reorganizing The Dimeric Photoreceptor, E Sethe Burgie, Katherine Basore, Michael J Rau, Brock Summers, Alayna J Mickles, Vadim Grigura, James A J Fitzpatrick, Richard D Vierstra

2020-Current year OA Pubs

Phytochromes (Phys) are a divergent cohort of bili-proteins that detect light through reversible interconversion between dark-adapted Pr and photoactivated Pfr states. While our understandings of downstream events are emerging, it remains unclear how Phys translate light into an interpretable conformational signal. Here, we present models of both states for a dimeric Phy with histidine kinase (HK) activity from the proteobacterium Pseudomonas syringae, which were built from high-resolution cryo-EM maps (2.8-3.4-Å) of the photosensory module (PSM) and its following signaling (S) helix together with lower resolution maps for the downstream output region augmented by RoseTTAFold and AlphaFold structural predictions. The head-to-head …

The "Other" Founder - Lincoln Fleetwood Sise, David J. Schoetz

The Lahey Journal

No abstract provided.

The Role Of Aarp Mississippi In Healthy Aging, Kimberly Campbell, Melinda Bertucci

Journal of Public Health in the Deep South

No abstract provided.

Integrated Delivery Of Health Care And Continuity Of Care For Older Mississippians With Mental And Behavioral Health Concerns, Tockie V. Hemphill

Journal of Public Health in the Deep South

The mental health of older adults is of national concern. There is some uncertainty regarding access to care and whether mental and behavioral health care will be readily available in primary care settings. This paper explores the concepts of integrated delivery of care and continuity of care for older adults. The definitions of the two concepts vary in detail, but are similar in purpose. There is an array of strategies presented that outline a continuity of care that involves an integrated delivery system. Relationship development is the core of this system, as well as older adults’ ability and willingness to …

Aging Redefined: Moving Past The Deficit Model, Aaron Guest

Journal of Public Health in the Deep South

The remarkable increase in longevity is the pivotal triumph of public health over the last two centuries. Yet, even as we experience the benefits of increased longevity, we continue to face rampant ageism – or the prejudice and discrimination directed at individuals perceived as 'old.' Worst of all, we know that ageism is associated with increased medical costs, poorer health outcomes, and increased mortality. Efforts to combat ageism have been insufficient. The triumvirate of ageism, gerontological illiteracy, and gerontophobia have resulted in a deficit model of aging. Far from being a liability, the rapid increase in the aging population presents …

Caregiver To Caregiver: An Exploratory Case Study In Adult Family Caregiving Experiences, Tamara Brocks, Kaye Bender

Journal of Public Health in the Deep South

Adult family caregiving is a national public health issue which is more prominently recognized since the COVID pandemic. The National Strategy to Support Family Caregivers (2022) highlights more than three hundred federal government actions in support of family caregivers and more than 150 actions that can be addressed at other levels of government with their partnerships to build a caregiver support system. A partnership between the Mississippi State Department of Health (MSDH), the Mississippi Public Health Association (MPHA) and AARP MS is working to address many of the issues related to the heathy aging ecosystem in Mississippi. This case study …

Implementing Policy To Increase Health Literacy In Falls Prevention: A Teach-Back And Show-Back Intervention, Yalanda M. Barner, Lollie Vaughan-Robinson, Jazmin Adjei

Journal of Public Health in the Deep South

Background: Although falls are preventable, falls among older adults remain a public health concern. Research indicates that over one-third of persons over 65 fall. Approximately 3 million report to emergency rooms due to falls annually. Falls are attributed to health conditions such as cognitive impairment, poor eyesight, arthritis, and polypharmacy.

Purpose: This study adapted the Teach-Back/Show-Back method for older persons in adult daycare and faith-based settings to assess their understanding of falls prevention techniques. Therefore, the purpose of this study was to examine the risk factors, prevention strategies, and policy recommendations of falls prevention among older adults.

Methods: A survey …

Personality Profile Of Rural-Dwelling Older Adults With Hoarding Disorder, Mary E. Dozier, Caitlyn A. Nix, Hilary L. Deshong

Journal of Public Health in the Deep South

Hoarding in late life represents a major barrier to aging in place, particularly for rural-dwelling older adults. One risk factor for hoarding disorder in late life may be underlying personality factors. However, there has not yet been an investigation of late life hoarding and possible maladaptive personality factors from the continuous five-factor model perspective in a sample of individuals diagnosed with hoarding disorder. Thus, we evaluated the five-factor personality profiles of older adults enrolled in treatment studies for hoarding disorder in rural Mississippi. Raw scores on the International Personality Item Pool-NEO-60 were converted into categories of Low (<1SD from …

Chronic Obstructive Pulmonary Disease Hot Spots In Mississippi, Taylor Jansen, Elizabeth Dugan

Journal of Public Health in the Deep South

Abstract

Introduction. Chronic obstructive pulmonary disease (COPD) is the sixth leading cause of death in the US and approximately 10% of people 65 years and older have COPD. This study examines the association of geographic-level risk factors with chronic obstructive pulmonary disease (COPD) prevalence using spatial-based analyses with the goal of identifying risk factors associated with county-level COPD and to identify communities at risk.

Methods. The study sample consisted of all N=82 counties in Mississippi and all data is reported at the county level. All measures were drawn from the 2023 Mississippi Healthy Aging Data Report. A hot spot …