Medicine and Health Sciences Commons^™

Inclusiveness Of English As A Second Language Nursing Students In The Academic Setting, Bahgat Youwakeem

Walden Dissertations and Doctoral Studies

This study explored the perceptions of English as a Second Language (ESL) nursing students regarding inclusiveness in nursing programs in the southern United States. The problem addressed is the limited research on how ESL nursing students perceive inclusiveness in academic environments, particularly in the Southern States, where diversity is increasing. Previous studies have focused on the general challenges faced by ESL students, but few have examined their specific perceptions of inclusivity in nursing programs. The purpose of this qualitative phenomenological study, guided by Whannell and Whannell’s identity theory, was to gain insights into ESL nursing students' lived experiences of inclusiveness. …

Developmental-Status-Aware Transcriptional Decomposition Establishes A Cell State Panorama Of Human Cancers, Yikai Luo, Han Liang

Faculty, Staff and Student Publications

Background: Cancer cells evolve under unique functional adaptations that unlock transcriptional programs embedded in adult stem and progenitor-like cells for progression, metastasis, and therapeutic resistance. However, it remains challenging to quantify the stemness-aware cell state of a tumor based on its gene expression profile.

Methods: We develop a developmental-status-aware transcriptional decomposition strategy using single-cell RNA-sequencing-derived tissue-specific fetal and adult cell signatures as anchors. We apply our method to various biological contexts, including developing human organs, adult human tissues, experimentally induced differentiation cultures, and bulk human tumors, to benchmark its performance and to reveal novel biology of entangled developmental signaling in …

Prenatal Opioid And Alcohol Exposures: Association With Altered Placental Serotonin Transporter Structure And/Or Expression, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Sandra Adele, Armine Darbinyan, Mary F Morrison, C Lindsay Devane, Sammanda Ramamoorthy, Laura Goetzl, Michael E Selzer

Faculty, Staff and Student Publications

Fetal exposures to many drugs of abuse, e.g., opioids and alcohol (EtOH), are associated with adverse neurodevelopmental problems in early childhood, including abnormalities in activity of the serotonin (5HT) transporter (SERT), which transports 5HT across the placenta. Little is known about the effects of these drugs on SERT expression. Pregnant women who used EtOH or opioids were compared to gestational age-matched controls using a structured questionnaire to determine prenatal substance exposure. Following elective pregnancy termination, placental membranous vesicles and exosomes were prepared from first and second trimester human placentas. Changes in EtOH- or opioid-exposed placental SERT expression and modifications were …

Dna-Binding Proteins From Mbd Through Zf To Ben: Recognition Of Cytosine Methylation Status By One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, Xiaodong Cheng

Faculty, Staff and Student Publications

Maintenance methylation, of palindromic CpG dinucleotides at DNA replication forks, is crucial for the faithful mitotic inheritance of genomic 5-methylcytosine (5mC) methylation patterns. MBD proteins use two arginine residues to recognize symmetrically-positioned methyl groups in fully-methylated 5mCpG/5mCpG and 5mCpA/TpG dinucleotides. In contrast, C2H2 zinc finger (ZF) proteins recognize CpG and CpA, whether methylated or not, within longer specific sequences in a site- and strand-specific manner. Unmethylated CpG sites, often within CpG island (CGI) promoters, need protection by protein factors to maintain their hypomethylated status. Members of the BEN domain proteins bind CGCG or CACG elements within CGIs to regulate gene …

Rezafungin Versus Caspofungin For Patients With Candidaemia Or Invasive Candidiasis In The Intensive Care Unit: Pooled Analyses Of The Restore And Strive Randomised Trials, Patrick M Honoré, Massimo Girardis, Marin Kollef, Oliver A Cornely, George R Thompson Iii, Matteo Bassetti, Alex Soriano, Haihui Huang, Jose Vazquez, Bart Jan Kullberg, Peter G Pappas, Nick Manamley, Taylor Sandison, John Pullman, Saad Nseir

2020-Current year OA Pubs

BACKGROUND: Rezafungin is an echinocandin approved in the US and EU to treat candidaemia and/or invasive candidiasis. This post-hoc, pooled analysis of the Phase 2 STRIVE and Phase 3 ReSTORE trials assessed rezafungin versus caspofungin in patients with candidaemia and/or invasive candidiasis (IC) in the intensive care unit (ICU) at randomisation.

METHODS: STRIVE and ReSTORE were randomised double-blind trials in adults with systemic signs and mycological confirmation of candidaemia and/or IC in blood or a normally sterile site ≤ 96 h before randomisation. Data were pooled for patients in the ICU at randomisation who received intravenous rezafungin (400 mg loading …

Effective Deep Brain Stimulation For Obsessive-Compulsive Disorder After Failed Anterior Capsulotomy: Illustrative Cases, Anthony K Allam, Nisha Giridharan, Mohammed Hasen, Garrett P Banks, Gabriel Reyes, Huy Dang, Katherine E Kabotyanski, Alyssa G Hertz, Sarah R Heilbronner, Nicole Provenza, Eric A Storch, Wayne K Goodman, Sameer A Sheth

Faculty, Staff and Students Publications

BACKGROUND: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions) performed to relieve distress related to the obsessions. For patients with severe illness refractory to first-line pharmacotherapy and psychotherapy, neurosurgical treatments such as deep brain stimulation (DBS) and stereotactic lesioning are an option. The choice between DBS and lesioning is often driven by patient preference, but these options are not mutually exclusive. Here, the authors highlight the success of one surgical therapy (DBS) after the failure of another (lesioning).

OBSERVATIONS: Two patients with severe, treatment-refractory OCD underwent DBS lead implantation targeting the …

Targeting Trem2 Signaling Shows Limited Impact On Cerebrovascular Calcification, Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

2020-Current year OA Pubs

Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (TREM2) in the

Partial Wrapping Of Single-Stranded Dna By Replication Protein A And Modulation Through Phosphorylation, Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony

2020-Current year OA Pubs

Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper to direct the ssDNA towards downstream DNA metabolic pathways with exceptional specificity. Understanding the mechanistic basis for such RPA-dependent functional specificity requires knowledge of the structural conformation of ssDNA when RPA-bound. Previous studies suggested a stretching of ssDNA by RPA. However, structural investigations uncovered a partial wrapping of ssDNA around RPA. Therefore, to reconcile the models, in this study, we measured the end-to-end distances of free ssDNA and RPA-ssDNA complexes using single-molecule FRET and …

Engineered Cas9 Variants Bypass Keap1-Mediated Degradation In Human Cells And Enhance Epigenome Editing Efficiency, Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Dennis Goldfarb, Erica W Cloer, George W Small, Smaran Sivashankar, Dale A Ramsden, Michael B Major, Nathaniel A Hathaway, Charles A Gersbach, Pengda Liu

2020-Current year OA Pubs

As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered variants of Cas9, dCas9 and other related prokaryotic endonucleases have been identified. However, as these bacterial enzymes are not naturally present in mammalian cells, whether and how bacterial Cas9 proteins are recognized and regulated by mammalian hosts remain poorly understood. Here, we identify Keap1 as a mammalian endogenous E3 ligase that targets Cas9/dCas9/Fanzor for ubiquitination and degradation in an 'ETGE'-like degron-dependent manner. Cas9-'ETGE'-like degron mutants evading Keap1 recognition display enhanced gene editing ability in cells. dCas9-'ETGE'-like degron …

A Veteran Mental Health Approach Sustaining Identity Post-Military Life: A Comprehensive Overview, Darren Sosa, Lindsay Gietzen

Pacific Journal of Health

Veterans and their mental health face readjustment challenges based on veteran identity, intersectionality, and experiences from their time serving in the military. This comprehensive overview and PRISMA analysis investigate the current evidence-based practices of veterans' identity and intersectionality. Specifically, psychoeducation and evidence-based practices for veterans readjusting back into their communities. A gap identified in this research’s findings calls for suggestions for future research on the veteran population and intersectionality. No specific psychoeducation or evidence-based practices tailored for identity readjustment or veteran intersectionality were found. This research constructs a tailored framework of suggestions for current and future evidence-based practices for the …

Preparedness For Practice Of Health Professionals In Papua New Guinea: A Cross-Sectional Survey Of Nurses And Community Health Workers., Mary Kililo, Julie Dopsie, Sulpain Passingan, Julie Kep, Nina Joseph, Russel Kitau, Mary Roroi, Chris Rossiter, Jenny Sim, Di Brown, Caroline Havery, Ali Moloney, Michele Rumsey

Pacific Journal of Health

Introduction

Papua New Guinea (PNG) experiences widespread health inequity and shortage of health professionals, exacerbated by poverty, isolation, gender-based violence and limited infrastructure, transport and accessible services. Nurses and community health workers (CHW) represent 72% of health workforce. However, health professional education programs are outdated and not aligned with national health priorities. We aimed to explore the adequacy of current curricula for nurses and CHWs by examining graduate competencies and preparedness for practice.

Methods

Cross-sectional study with four cohorts: 1) 130 new nurse graduates, 2) 75 nurses who supervised them, 3) 105 new CHW graduates and 4) 65 CHW supervisors. …

Social Determinants Of Health And How They Affect A Small Rural Community (Case Study) Eastern Shore Of Maryland, Kristopher S. Durham, Lindsay Gietzen

Pacific Journal of Health

The Eastern Shore of Maryland is rural and is characterized by prevalent poverty, housing instability, lack of access to healthcare, chronic diseases, substance abuse, and issues with transportation to access healthcare services. The same problems exist for the population in Maryland and the United States. Understanding the challenges experienced by rural communities in Maryland is critical to addressing the vulnerable population. This study is an explanatory case study that examines the social determinants of health and how those affect small rural communities on the Eastern Shore of Maryland by examining literature published between 2016 and 2024. The literature reviewed resulted …

Staff Education Project For Adult Icu Nurses, Hani Ayyad

Walden Dissertations and Doctoral Studies

This staff education project is a crucial initiative designed to enhance nursing knowledge and skills in the care of central lines. Its overarching goal is to reduce the incidence of central line-associated bloodstream infections (CLABSI) in a teaching hospital. Given that CLABSIs are a major concern in Intensive Care Units (ICUs), due to higher morbidity, mortality, and healthcare expenditures, this project is very important. My goal was to fill these gaps by providing a comprehensive staff education program addressing this critical issue. The evidence-based practice question (EBP) guiding this Doctor of Nursing Project (DNP) project was: Does the Staff Education …

Lived Experiences Of Low-Income African American Burn Survivors In Greater Washington, Dc, Angela White

Walden Dissertations and Doctoral Studies

Burn injuries are wounds that affect the skin and other organic tissue, categorized according to the mechanism of injury and brought on by heat, electricity, chemicals, fire, or flames. In the United States, researchers have shown that race and other healthcare inequalities lead to increased burn injuries among African Americans but have yet to explore their lived experiences after sustaining these injuries. This phenomenological study explored perceptions and understanding of the manifestation of burn injuries of seven African American burn survivors. Participants were recruited in health services public waiting areas, community storefronts, mailers, and on Facebook. Data were collected via …

The Contribution Of Neutrophil Extracellular Traps To Coagulopathy In Patients With Covid-19-Related Thrombosis, Carolyn Enochs, Gabriela Delevati Colpo, Lucy Couture, Lynae Baskin, Ana E Cahuiche, Eunyoung Angela Lee, Shahid Nimjee, Louise D Mccullough

Faculty, Staff and Student Publications

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, …

A Genome-Wide Association Study Identifies Genetic Determinants Of Hemoglobin Glycation Index With Implications Across Sex And Ethnicity, John S. House, Joseph H. Breeyear, Farida S. Akhtari, Violet Evans, John B. Buse, James Hempe, Alessandro Doria, Josyf C. Mychaleckyi, Vivian Fonseca, Mengyao Shi, Changwei Li, Shuqian Liu, Tanika N. Kelly, Daniel Rotroff, Alison A. Motsinger-Reif

School of Medicine Faculty Publications

Introduction: We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications. Methods: We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race. Results: In ACCORD, we identified single …

Assessing The Impact Of Dietary Supplements On Diabetic Quality Of Life: Insights From The Eq-5d Model, Inas Rifaat Ibrahim

Maaen Journal for Medical Sciences

The use of dietary supplements (DS) has been observed to be increasing among patients with diabetes. However, the effect of DS on health-related quality of life (HRQoL) is still an understudied area. This study aims to evaluate the prevalence of DS use among diabetic patients, their attitudes toward these supplements, and their effect on HRQoL. A cross-sectional study was conducted among diabetic patients attending an outpatient facility in Iraq. A validated survey instrument was used to collect data on DS use, attitudes, and HRQoL using EQ-5D measures. The study found that 73.8% of patients used DS, including omega-3 fatty acids, …

Evaluation Of One Stage Bilateral Total Knee Arthroplasty Versus Staged Bilateral Total Knee Arthroplasty, Ahmed Sarhan Mazyon

Maaen Journal for Medical Sciences

Background: Complete knee replacement is a resolving method for treatment for severe osteoarthritis and rheumatoid arthritis that relieves pain and restores function. Individuals in necessary condition to do bilateral surgery total knee arthroplasty underwent two different surgical procedures, or one stage of surgery with one anesthesia session. Aim of the study: To compare the knee and functional outcome, safety, and possible complications between one stage and staged bilateral total knee arthroplasty. Patients and methods: An interventional study conducted in the Orthopedic Department in Al-Yarmouk Teaching Hospital and private hospital, Baghdad, Iraq during a time of three years from (June 2020 …

Right Heart Failure After Tricvalve Implantation For Symptomatic Torrential Tricuspid Regurgitation: A Case Report, King Sum Luk, Chun Kit Wong

Journal of the Hong Kong College of Cardiology

Patients with symptomatic torrential tricuspid regurgitation (TR) presenting with right heart failure are associated with significant morbidity and mortality. While medical therapy is often ineffective, the perioperitive risks of surgical correction are high. Transcatheter TricValve implantation is one of the evolving therapeutic options for this condition with many unanswered questions. We reported a case of life-threatening right heart failure after transcatheter TricValve implantation despite initial improvement. Important considerations of TricValve implantation are discussed. In particular, careful patient selection and evaluation with perioperative echocardiogram are of paramount importance.

From Books To The Bedside: Post-Graduation Impact Of 'Week On The Wards' On Medical Education., Ashley Russell, Kimberly Eberenz, Meena Khandelwal

Cooper Medical School of Rowan University Departmental Research

BACKGROUND: The transition between preclinical and clinical years during medical school has been shown to be challenging. Cooper Medical School of Rowan University (CMSRU) implements one required two-week-long shadowing program for first and one one-week-long shadowing program for second-year medical students called Week On the Wards (WOW). The goal of this study is to ascertain whether students who completed the WOW curriculum found it beneficial over the long-term. Specifically, we want to evaluate alumni's impression of the program's influence on career, specialty choice, professional development, personal development, and confidence.

METHODS: To evaluate our program, we developed, validated, and distributed a …

Y-27632 Targeting Rock1&2 Modulates Cell Growth, Fibrosis And Epithelial-Mesenchymal Transition In Hyperplastic Prostate By Inhibiting Β-Catenin Pathway., Shidong Shan, Min Su, Hejin Wang, Feng Guo, Yan Li, Yongying Zhou, Huan Liu, Lu Du, Junchao Zhang, Jizhang Qiu, Michael E. Disanto, Yuming Guo, Xinhua Zhang

Cooper Medical School of Rowan University Departmental Research

Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the male urinary system, with its molecular mechanisms of pathogenesis remaining unclear. Y-27632, a non-isoform-selective Rho kinase inhibitor, has shown therapeutic potential in various diseases but its effects on static factors and fibrosis in BPH remain unexplored. This study investigated human prostate tissues, human prostate cell lines, and BPH rat model using immunofluorescence, flow cytometry, quantitative reverse transcription polymerase chain reaction, western blotting, and cell counting kit-8. ROCK1 and ROCK2 were significantly up-regulated in BPH tissues, correlating with clinical parameters. Y-27632 targeted the inhibition of ROCK1 & ROCK2 expression and inhibited …

There Is "Thorn" Than Meets The Eye, Zaid Alnabulsi

Conference Presentation Abstracts

No abstract provided.

Radiomics-Based Machine Learning With Natural Gradient Boosting For Continuous Survival Prediction In Glioblastoma, Mert Karabacak, Shiv Patil, Zachary C. Gersey, Ricardo J. Komotar, Konstantinos Margetis

SKMC Student Presentations and Publications

(1) Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with an aggressive disease course that requires accurate prognosis for individualized treatment planning. This study aims to develop and evaluate a radiomics-based machine learning (ML) model to estimate overall survival (OS) for patients with GBM using pre-treatment multi-parametric magnetic resonance imaging (MRI). (2) Methods: The MRI data of 865 patients with GBM were assessed, comprising 499 patients from the UPENN-GBM dataset and 366 patients from the UCSF-PDGM dataset. A total of 14,598 radiomic features were extracted from T1, T1 with contrast, T2, and FLAIR MRI sequences …

Chronic Intestinal Pseudo-Obstruction: A Debilitating Complication Of Scleroderma, Pawan Gyawali

Conference Presentation Abstracts

No abstract provided.

Myxedema Coma Due To Interrupted Levothyroxine Therapy, Tajuldeen Al Hasani

Conference Presentation Abstracts

No abstract provided.

A Rare Case Of An Immune Checkpoint Inhibitor-Induced Myopericarditis, Morgan Korn

Conference Presentation Abstracts

No abstract provided.

The Kitchen Sink Approach: A Case Of Idiopathic Non-Histaminergic Angioedema, Vickie Xin

Conference Presentation Abstracts

No abstract provided.

Rheumatoid Arthritis And Anca Vasculitis Overlap: A Rare Case With Renal And Respiratory Involvement, Ayed Shahatit

Conference Presentation Abstracts

No abstract provided.

Cardiac Tamponade As An Initial Manifestation Of Lung Adenocarcinoma, Lark Steafo

Conference Presentation Abstracts

No abstract provided.

Disseminated Lyme Leading To Complete Heart Block, Lara Hakim

Conference Presentation Abstracts

No abstract provided.